CodePCA
NamePidolic acid
Synonyms5-L-oxoproline
Identifier(2S)-5-oxopyrrolidine-2-carboxylic acid
FormulaC5 H7 N O3
Molecular Weight129.114
SMILESC1CC(=O)N[C@@H]1C(=O)O
PubChem7405
Formal Charge0
Total Atoms16
Total Chiral Atoms1
Total Bonds16
Total Aromatic Bonds0
Networks14
 missing image

This ligand is also present in the following 14 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4XT1 A Other Unclassified US28 Human cytomegalovirus (strain AD169) Fractalkine - - 2.89 2015-03-04 10.1126/science.aaa5026

A 2D representation of the interactions of PCA in 4XT1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H26 R:R:Y40 5.44 2 Yes Yes 0 7 1 2
R:R:W89 R:R:Y92 3.86 2 Yes Yes 7 6 2 2
R:R:F111 R:R:W89 4.01 2 Yes Yes 7 7 2 2
L:L:H26 R:R:W89 11.64 2 Yes Yes 0 7 1 2
L:L:V29 R:R:W89 13.48 2 Yes Yes 0 7 1 2
R:R:C173 R:R:Y92 6.72 0 No Yes 9 6 1 2
L:L:V29 R:R:Y92 5.05 2 Yes Yes 0 6 1 2
L:L:V29 R:R:L93 5.96 2 Yes No 0 6 1 2
R:R:C104 R:R:C173 7.28 0 No No 9 9 2 1
R:R:T108 R:R:V166 12.69 2 No No 6 5 1 1
L:L:?25 R:R:T108 6.28 2 Yes No 0 6 0 1
R:R:F111 R:R:Y112 12.38 2 Yes Yes 7 5 2 1
L:L:H26 R:R:F111 22.63 2 Yes Yes 0 7 1 2
R:R:F116 R:R:Y112 4.13 2 Yes Yes 7 5 2 1
R:R:H162 R:R:Y112 18.51 2 Yes Yes 4 5 2 1
L:L:?25 R:R:Y112 9.98 2 Yes Yes 0 5 0 1
R:R:F116 R:R:H162 4.53 2 Yes Yes 7 4 2 2
R:R:T175 R:R:V165 4.76 0 No No 5 5 1 2
L:L:?25 R:R:V166 11.1 2 Yes No 0 5 0 1
L:L:?25 R:R:C173 3.38 2 Yes No 0 9 0 1
R:R:T175 R:R:Y177 12.48 0 No No 5 5 1 2
L:L:?25 R:R:T175 4.71 2 Yes No 0 5 0 1
L:L:H26 R:R:E277 12.31 2 Yes Yes 0 6 1 2
L:L:?25 L:L:H26 6.84 2 Yes Yes 0 0 0 1
L:L:?25 L:L:V29 3.17 2 Yes Yes 0 0 0 1
L:L:G28 L:L:H26 3.18 0 No Yes 0 0 2 1
L:L:H26 L:L:V29 9.69 2 Yes Yes 0 0 1 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.49
Average Nodes In Shell20.00
Average Hubs In Shell11.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4XT3 A Other Unclassified US28 Human cytomegalovirus (strain AD169) Fractalkine - - 3.8 2015-03-04 10.1126/science.aaa5026

A 2D representation of the interactions of PCA in 4XT3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H26 R:R:Y40 5.44 1 Yes Yes 0 7 1 2
R:R:W89 R:R:Y92 3.86 1 Yes Yes 7 6 2 2
R:R:F111 R:R:W89 5.01 1 Yes Yes 7 7 2 2
L:L:H26 R:R:W89 14.81 1 Yes Yes 0 7 1 2
L:L:V29 R:R:W89 11.03 1 Yes Yes 0 7 2 2
R:R:C173 R:R:Y92 9.41 0 No Yes 9 6 1 2
L:L:V29 R:R:Y92 5.05 1 Yes Yes 0 6 2 2
R:R:C104 R:R:C173 7.28 0 No No 9 9 2 1
R:R:T108 R:R:V166 9.52 1 No No 6 5 1 1
L:L:?25 R:R:T108 6.28 1 Yes No 0 6 0 1
R:R:F111 R:R:Y112 14.44 1 Yes Yes 7 5 2 1
L:L:H26 R:R:F111 20.36 1 Yes Yes 0 7 1 2
R:R:F116 R:R:Y112 3.09 1 Yes Yes 7 5 2 1
R:R:H162 R:R:Y112 17.42 1 Yes Yes 4 5 2 1
L:L:?25 R:R:Y112 4.99 1 Yes Yes 0 5 0 1
R:R:F116 R:R:H162 5.66 1 Yes Yes 7 4 2 2
R:R:T175 R:R:V165 4.76 0 No No 5 5 1 2
L:L:?25 R:R:V166 11.1 1 Yes No 0 5 0 1
L:L:?25 R:R:C173 5.07 1 Yes No 0 9 0 1
R:R:T175 R:R:Y177 9.99 0 No No 5 5 1 2
L:L:?25 R:R:T175 4.71 1 Yes No 0 5 0 1
L:L:H26 R:R:E277 12.31 1 Yes Yes 0 6 1 2
L:L:?25 L:L:H26 6.84 1 Yes Yes 0 0 0 1
L:L:H26 L:L:V29 8.3 1 Yes Yes 0 0 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.50
Average Nodes In Shell18.00
Average Hubs In Shell11.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5UIW A Protein Chemokine CCR5 Homo sapiens 5P7-CCL5 - - 2.2 2017-06-28 10.1016/j.immuni.2017.05.002

A 2D representation of the interactions of PCA in 5UIW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:M5 R:R:S179 6.13 3 Yes No 0 3 1 2
R:R:F182 R:R:S180 6.61 0 Yes No 5 4 2 1
L:L:?0 R:R:S180 4.79 3 Yes No 0 4 0 1
L:L:M5 R:R:S180 4.6 3 Yes No 0 4 1 1
R:R:L255 R:R:T195 4.42 3 No No 6 5 1 1
R:R:T195 R:R:T259 14.13 3 No No 5 5 1 2
L:L:?0 R:R:T195 7.84 3 Yes No 0 5 0 1
R:R:L255 R:R:Y251 11.72 3 No Yes 6 7 1 2
L:L:?0 R:R:L255 4.42 3 Yes No 0 6 0 1
L:L:?0 L:L:G1 7.28 3 Yes No 0 0 0 1
L:L:?0 L:L:M5 6.02 3 Yes Yes 0 0 0 1
L:L:G1 L:L:P2 4.06 0 No Yes 0 0 1 2
L:L:M5 L:L:P2 5.03 3 Yes Yes 0 0 1 2
L:L:M5 L:L:S31 6.13 3 Yes No 0 0 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.07
Average Nodes In Shell12.00
Average Hubs In Shell5.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell12.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F8V A Peptide Cholecystokinin CCKB Homo sapiens Gastrin-17 - Gi2/Beta1/Gamma2 3.3 2021-10-13 10.1038/s41589-021-00866-8

A 2D representation of the interactions of PCA in 7F8V
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:G2 7.28 0 No No 0 0 0 1
L:L:?1 R:R:R57 14.22 0 No Yes 0 5 0 1
L:L:?1 R:R:G369 7.28 0 No No 0 3 0 1
L:L:G2 L:L:P3 4.06 0 No No 0 0 1 2
R:R:L116 R:R:R57 6.07 1 No Yes 5 5 2 1
R:R:A370 R:R:R57 4.15 0 No Yes 3 5 2 1
R:R:R57 R:R:S373 13.18 0 Yes No 5 5 1 2
L:L:G2 R:R:G118 2.11 0 No No 0 4 1 2
R:R:G369 R:R:P371 2.03 0 No No 3 5 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength9.59
Average Nodes In Shell10.00
Average Hubs In Shell1.00
Average Links In Shell9.00
Average Links Mediated by Hubs In Shell4.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F8W A Peptide Cholecystokinin CCKB Homo sapiens Gastrin-17 - chim(NtGsL-Gq)/Beta1/Gamma2 3.1 2021-10-13 10.1038/s41589-021-00866-8

A 2D representation of the interactions of PCA in 7F8W
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:G2 7.28 21 No No 0 0 0 1
L:L:?1 L:L:P3 3.5 21 No No 0 0 0 1
L:L:G2 L:L:P3 4.06 21 No No 0 0 1 1
R:R:N115 R:R:R57 3.62 0 No Yes 5 5 2 1
R:R:A370 R:R:R57 5.53 0 No Yes 3 5 2 1
R:R:R57 R:R:S373 10.54 0 Yes No 5 5 1 2
R:R:F374 R:R:R57 3.21 0 No Yes 5 5 2 1
L:L:?1 R:R:R57 2.59 21 No Yes 0 5 0 1
L:L:E6 L:L:P3 1.57 0 No No 0 0 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength4.46
Average Nodes In Shell9.00
Average Hubs In Shell1.00
Average Links In Shell9.00
Average Links Mediated by Hubs In Shell5.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7O7F A Protein Chemokine CCR5 Homo sapiens (6P4)CCL5 - Gi1/Beta1/Gamma1 3.15 2021-06-30 10.1126/sciadv.abg8685

A 2D representation of the interactions of PCA in 7O7F
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:G2 R:R:F109 3.01 0 No Yes 0 5 1 2
R:R:F182 R:R:Q194 7.03 14 Yes No 5 5 2 1
R:R:K197 R:R:Q194 6.78 0 Yes No 3 5 2 1
L:L:?1 R:R:Q194 7.08 0 Yes No 0 5 0 1
R:R:T195 R:R:T259 12.56 0 No No 5 5 1 2
L:L:?1 R:R:T195 7.84 0 Yes No 0 5 0 1
R:R:I198 R:R:L255 5.71 0 No Yes 5 6 2 1
R:R:L255 R:R:Y251 14.07 0 Yes Yes 6 7 1 2
R:R:L255 R:R:M279 5.65 0 Yes No 6 5 1 2
L:L:?1 R:R:L255 8.84 0 Yes Yes 0 6 0 1
L:L:?1 L:L:G2 7.28 0 Yes No 0 0 0 1
L:L:?1 L:L:K34 10.51 0 Yes No 0 0 0 1
L:L:G2 L:L:P3 4.06 0 No No 0 0 1 2
L:L:I7 L:L:K34 2.91 6 Yes No 0 0 2 1
L:L:K34 L:L:S32 4.59 0 No No 0 0 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub1.00
Average Interaction Strength8.31
Average Nodes In Shell16.00
Average Hubs In Shell7.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell12.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RKF A Other Unclassified US28 Human betaherpesvirus 5 Fractalkine GDP chim(NtGi1-G11)/Beta1/Gamma2 4 2022-01-26 10.1126/sciadv.abl5442

A 2D representation of the interactions of PCA in 7RKF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:H2 4.11 1 Yes Yes 0 0 0 1
L:L:?1 L:L:V5 4.76 1 Yes No 0 0 0 1
L:L:?1 R:R:W89 6.06 1 Yes Yes 0 7 0 1
L:L:?1 R:R:T108 3.14 1 Yes No 0 6 0 1
L:L:H2 R:R:Y40 2.18 1 Yes Yes 0 7 1 2
L:L:H2 R:R:W89 4.23 1 Yes Yes 0 7 1 1
L:L:H2 R:R:F111 2.26 1 Yes Yes 0 7 1 2
L:L:H2 R:R:Y112 2.18 1 Yes No 0 5 1 2
L:L:H2 R:R:E277 2.46 1 Yes Yes 0 6 1 2
R:R:E277 R:R:Y40 3.37 1 Yes Yes 6 7 2 2
R:R:W89 R:R:Y92 8.68 1 Yes No 7 6 1 2
R:R:L107 R:R:W89 2.28 0 No Yes 5 7 2 1
R:R:C104 R:R:C173 7.28 0 No No 9 9 2 1
R:R:F111 R:R:Y112 5.16 1 Yes No 7 5 2 2
L:L:?1 R:R:C173 1.69 1 Yes No 0 9 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength3.95
Average Nodes In Shell13.00
Average Hubs In Shell6.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell14.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RKM A Other Unclassified US28 Human betaherpesvirus 5 Fractalkine - Gi1/Beta1/Gamma2 3.5 2022-01-26 10.1126/sciadv.abl5442

A 2D representation of the interactions of PCA in 7RKM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:H2 5.47 1 Yes Yes 0 0 0 1
L:L:?1 R:R:T108 7.84 1 Yes No 0 6 0 1
L:L:?1 R:R:Y112 12.48 1 Yes Yes 0 5 0 1
L:L:?1 R:R:V166 4.76 1 Yes Yes 0 5 0 1
L:L:?1 R:R:T175 4.71 1 Yes No 0 5 0 1
L:L:G4 L:L:H2 3.18 0 No Yes 0 0 2 1
L:L:H2 L:L:V5 13.84 1 Yes Yes 0 0 1 2
L:L:H2 R:R:Y40 4.36 1 Yes No 0 7 1 2
L:L:H2 R:R:W89 7.41 1 Yes Yes 0 7 1 2
L:L:H2 R:R:F111 13.58 1 Yes Yes 0 7 1 2
L:L:H2 R:R:E277 3.69 1 Yes Yes 0 6 1 2
L:L:H2 R:R:F281 5.66 1 Yes Yes 0 7 1 2
L:L:V5 R:R:W89 3.68 1 Yes Yes 0 7 2 2
R:R:F281 R:R:Y40 7.22 1 Yes No 7 7 2 2
R:R:T108 R:R:W89 6.06 1 No Yes 6 7 1 2
R:R:F111 R:R:W89 4.01 1 Yes Yes 7 7 2 2
R:R:T108 R:R:V166 7.93 1 No Yes 6 5 1 1
R:R:F111 R:R:Y112 10.32 1 Yes Yes 7 5 2 1
R:R:F111 R:R:F281 5.36 1 Yes Yes 7 7 2 2
R:R:F116 R:R:Y112 4.13 1 Yes Yes 7 5 2 1
R:R:H162 R:R:Y112 18.51 1 Yes Yes 4 5 2 1
R:R:F116 R:R:H162 3.39 1 Yes Yes 7 4 2 2
R:R:T175 R:R:V165 4.76 0 No Yes 5 5 1 2
R:R:C173 R:R:V166 3.42 0 No Yes 9 5 2 1
R:R:T175 R:R:Y177 12.48 0 No No 5 5 1 2
R:R:E277 R:R:F281 8.16 1 Yes Yes 6 7 2 2
R:R:T105 R:R:V166 1.59 0 No Yes 8 5 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.05
Average Nodes In Shell19.00
Average Hubs In Shell12.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RKN A Other Unclassified US28 Human betaherpesvirus 5 Fractalkine - Gi1/Beta1/Gamma2 3.6 2022-01-26 10.1126/sciadv.abl5442

A 2D representation of the interactions of PCA in 7RKN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:H2 5.47 8 No Yes 0 0 0 1
L:L:?1 R:R:W89 6.06 8 No Yes 0 7 0 1
L:L:?1 R:R:V166 3.17 8 No No 0 5 0 1
L:L:G4 L:L:H2 3.18 8 No Yes 0 0 2 1
L:L:H2 L:L:V5 8.3 8 Yes No 0 0 1 2
L:L:H2 R:R:Y40 4.36 8 Yes Yes 0 7 1 2
L:L:H2 R:R:W89 4.23 8 Yes Yes 0 7 1 1
L:L:H2 R:R:F111 10.18 8 Yes Yes 0 7 1 2
L:L:H2 R:R:E277 11.08 8 Yes Yes 0 6 1 2
L:L:G4 R:R:E277 3.27 8 No Yes 0 6 2 2
L:L:V5 R:R:W89 9.81 8 No Yes 0 7 2 1
R:R:W89 R:R:Y92 3.86 8 Yes No 7 6 1 2
R:R:L107 R:R:W89 13.67 0 Yes Yes 5 7 2 1
R:R:F111 R:R:W89 4.01 8 Yes Yes 7 7 2 1
R:R:C173 R:R:V166 1.71 31 No No 9 5 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength4.90
Average Nodes In Shell12.00
Average Hubs In Shell6.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WKD A Peptide Thyrotropin-releasing hormone TRH Homo sapiens TRH - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.01 2022-06-15 10.1038/s41422-022-00641-x

A 2D representation of the interactions of PCA in 7WKD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:T102 R:R:Y106 4.99 2 No Yes 4 5 2 2
L:L:H2 R:R:T102 9.58 2 Yes No 0 4 1 2
R:R:W160 R:R:Y106 36.66 2 Yes Yes 5 5 2 2
R:R:Y106 R:R:Y181 3.97 2 Yes Yes 5 4 2 1
R:R:Y106 R:R:Y192 3.97 2 Yes Yes 5 5 2 1
L:L:H2 R:R:Y106 7.62 2 Yes Yes 0 5 1 2
L:L:?3 R:R:Y106 6.44 2 Yes Yes 0 5 2 2
R:R:W160 R:R:Y192 7.72 2 Yes Yes 5 5 2 1
L:L:H2 R:R:C179 7.37 2 Yes No 0 9 1 2
R:R:R185 R:R:Y181 7.2 2 Yes Yes 2 4 1 1
R:R:Y181 R:R:Y188 16.88 2 Yes No 4 5 1 2
R:R:Y181 R:R:Y192 10.92 2 Yes Yes 4 5 1 1
L:L:?1 R:R:Y181 4.99 2 Yes Yes 0 4 0 1
L:L:H2 R:R:Y181 5.44 2 Yes Yes 0 4 1 1
R:R:R185 R:R:Y192 7.2 2 Yes Yes 2 5 1 1
L:L:?1 R:R:R185 11.64 2 Yes Yes 0 2 0 1
R:R:V286 R:R:Y192 11.36 2 No Yes 6 5 1 1
L:L:?1 R:R:Y192 3.74 2 Yes Yes 0 5 0 1
R:R:V286 R:R:Y282 8.83 2 No Yes 6 5 1 1
R:R:C305 R:R:Y282 4.03 0 No Yes 5 5 2 1
R:R:I309 R:R:Y282 7.25 2 No Yes 6 5 2 1
L:L:?1 R:R:Y282 6.24 2 Yes Yes 0 5 0 1
L:L:?3 R:R:Y282 15.02 2 Yes Yes 0 5 2 1
R:R:L285 R:R:N289 9.61 2 No Yes 4 4 2 1
R:R:F296 R:R:L285 3.65 2 Yes No 1 4 2 2
R:R:C305 R:R:L285 3.17 0 No No 5 4 2 2
L:L:?1 R:R:V286 7.93 2 Yes No 0 6 0 1
R:R:F296 R:R:N289 4.83 2 Yes Yes 1 4 2 1
L:L:?1 R:R:N289 10.23 2 Yes Yes 0 4 0 1
R:R:L302 R:R:R306 3.64 0 No Yes 4 5 1 2
L:L:?1 R:R:L302 5.89 2 Yes No 0 4 0 1
L:L:?3 R:R:R306 12.23 2 Yes Yes 0 5 2 2
L:L:?3 R:R:I309 7.84 2 Yes No 0 6 2 2
L:L:?1 L:L:H2 4.11 2 Yes Yes 0 0 0 1
L:L:?3 L:L:H2 4.71 2 Yes Yes 0 0 2 1
R:R:N289 R:R:V288 2.96 2 Yes No 4 4 1 2
R:R:P295 R:R:R185 2.88 0 No Yes 1 2 2 1
L:L:H2 R:R:G180 1.59 2 Yes No 0 3 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.85
Average Nodes In Shell23.00
Average Hubs In Shell12.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7X1U A Peptide Thyrotropin-releasing hormone TRH Homo sapiens TRH - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.19 2022-08-31 10.1038/s41422-022-00646-6

A 2D representation of the interactions of PCA in 7X1U
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N82 R:R:R306 12.05 4 No Yes 6 5 2 1
R:R:N82 R:R:Y310 6.98 4 No Yes 6 7 2 2
L:L:?4 R:R:N82 10.27 4 Yes No 0 6 2 2
R:R:T102 R:R:W160 14.55 4 Yes Yes 4 5 2 2
L:L:H2 R:R:T102 6.85 4 Yes Yes 0 4 1 2
R:R:W160 R:R:Y106 30.87 4 Yes Yes 5 5 2 2
R:R:Y106 R:R:Y188 3.97 4 Yes Yes 5 5 2 2
R:R:Y106 R:R:Y192 8.94 4 Yes Yes 5 5 2 2
L:L:H2 R:R:Y106 5.44 4 Yes Yes 0 5 1 2
R:R:W160 R:R:Y181 3.86 4 Yes Yes 5 4 2 1
R:R:W160 R:R:Y188 12.54 4 Yes Yes 5 5 2 2
L:L:H2 R:R:W160 13.75 4 Yes Yes 0 5 1 2
R:R:G180 R:R:Y181 2.9 0 No Yes 3 4 2 1
R:R:R185 R:R:Y181 18.52 4 Yes Yes 2 4 1 1
R:R:Y181 R:R:Y188 9.93 4 Yes Yes 4 5 1 2
R:R:Y181 R:R:Y192 3.97 4 Yes Yes 4 5 1 2
L:L:?1 R:R:Y181 4.99 4 Yes Yes 0 4 0 1
L:L:H2 R:R:Y181 9.8 4 Yes Yes 0 4 1 1
R:R:R185 R:R:Y188 3.09 4 Yes Yes 2 5 1 2
R:R:R185 R:R:Y192 3.09 4 Yes Yes 2 5 1 2
R:R:N289 R:R:R185 4.82 4 Yes Yes 4 2 1 1
R:R:R185 R:R:S290 5.27 4 Yes No 2 4 1 2
L:L:?1 R:R:R185 9.05 4 Yes Yes 0 2 0 1
R:R:Y188 R:R:Y192 12.91 4 Yes Yes 5 5 2 2
R:R:V286 R:R:Y192 15.14 0 No Yes 6 5 1 2
R:R:S290 R:R:Y192 2.54 4 No Yes 4 5 2 2
R:R:V286 R:R:Y282 6.31 0 No Yes 6 5 1 2
R:R:C305 R:R:Y282 2.69 4 Yes Yes 5 5 2 2
L:L:P3 R:R:Y282 4.17 4 Yes Yes 0 5 2 2
R:R:L285 R:R:N289 8.24 4 Yes Yes 4 4 1 1
R:R:F301 R:R:L285 2.44 4 Yes Yes 4 4 2 1
R:R:L285 R:R:L302 4.15 4 Yes Yes 4 4 1 1
R:R:C305 R:R:L285 6.35 4 Yes Yes 5 4 2 1
L:L:?1 R:R:L285 2.95 4 Yes Yes 0 4 0 1
L:L:?1 R:R:V286 3.17 4 Yes No 0 6 0 1
R:R:N289 R:R:P295 11.4 4 Yes No 4 1 1 2
R:R:N289 R:R:Q297 5.28 4 Yes Yes 4 3 1 1
L:L:?1 R:R:N289 10.23 4 Yes Yes 0 4 0 1
R:R:P295 R:R:Q297 6.32 4 No Yes 1 3 2 1
R:R:L302 R:R:Q297 3.99 4 Yes Yes 4 3 1 1
L:L:?1 R:R:Q297 7.08 4 Yes Yes 0 3 0 1
R:R:C305 R:R:F301 4.19 4 Yes Yes 5 4 2 2
R:R:L302 R:R:R306 4.86 4 Yes Yes 4 5 1 1
L:L:?1 R:R:L302 7.37 4 Yes Yes 0 4 0 1
R:R:R306 R:R:Y310 8.23 4 Yes Yes 5 7 1 2
L:L:?1 R:R:R306 6.47 4 Yes Yes 0 5 0 1
L:L:P3 R:R:R306 4.32 4 Yes Yes 0 5 2 1
L:L:?4 R:R:R306 18.16 4 Yes Yes 0 5 2 1
L:L:P3 R:R:Y310 2.78 4 Yes Yes 0 7 2 2
L:L:?4 R:R:Y310 2.92 4 Yes Yes 0 7 2 2
L:L:?1 L:L:H2 10.95 4 Yes Yes 0 0 0 1
L:L:?4 L:L:P3 4.09 4 Yes Yes 0 0 2 2
R:R:N289 R:R:V288 1.48 4 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub8.00
Average Interaction Strength6.92
Average Nodes In Shell26.00
Average Hubs In Shell20.00
Average Links In Shell53.00
Average Links Mediated by Hubs In Shell53.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XBX A Protein Chemokine CX3CR1 Homo sapiens CX3CL1 - Gi1/Beta1/Gamma2 3.4 2022-07-13 10.1126/sciadv.abn8048

A 2D representation of the interactions of PCA in 7XBX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:T106 R:R:W87 8.49 1 Yes Yes 4 6 1 2
R:R:C175 R:R:W87 5.22 1 Yes Yes 9 6 2 2
L:L:H2 R:R:W87 9.52 1 Yes Yes 0 6 1 2
L:L:V5 R:R:W87 8.58 1 No Yes 0 6 2 2
R:R:F110 R:R:T106 3.89 1 Yes Yes 5 4 1 1
R:R:T106 R:R:T168 3.14 1 Yes No 4 5 1 1
R:R:C175 R:R:T106 5.07 1 Yes Yes 9 4 2 1
L:L:?1 R:R:T106 3.14 1 Yes Yes 0 4 0 1
R:R:F109 R:R:F110 5.36 0 Yes Yes 7 5 2 1
L:L:H2 R:R:F109 20.36 1 Yes Yes 0 7 1 2
R:R:F110 R:R:Q164 11.71 1 Yes Yes 5 4 1 2
R:R:F110 R:R:F165 3.22 1 Yes Yes 5 5 1 2
R:R:F110 R:R:R191 3.21 1 Yes Yes 5 5 1 1
L:L:?1 R:R:F110 9.07 1 Yes Yes 0 5 0 1
R:R:Q164 R:R:R191 9.35 1 Yes Yes 4 5 2 1
R:R:C175 R:R:T168 3.38 1 Yes No 9 5 2 1
L:L:?1 R:R:T168 3.14 1 Yes No 0 5 0 1
R:R:G177 R:R:Y179 8.69 0 No Yes 4 5 2 1
R:R:W187 R:R:Y179 10.61 1 Yes Yes 4 5 2 1
R:R:P188 R:R:Y179 2.78 0 No Yes 4 5 2 1
R:R:R191 R:R:Y179 7.2 1 Yes Yes 5 5 1 1
L:L:?1 R:R:Y179 3.74 1 Yes Yes 0 5 0 1
L:L:?1 R:R:R191 16.81 1 Yes Yes 0 5 0 1
L:L:H3 R:R:N192 3.83 0 No Yes 0 5 1 2
R:R:E279 R:R:F283 3.5 1 Yes Yes 5 6 2 2
L:L:H2 R:R:E279 8.62 1 Yes Yes 0 5 1 2
L:L:H2 R:R:F283 5.66 1 Yes Yes 0 6 1 2
L:L:?1 L:L:H2 4.11 1 Yes Yes 0 0 0 1
L:L:?1 L:L:H3 9.58 1 Yes No 0 0 0 1
L:L:H2 L:L:V5 6.92 1 Yes No 0 0 1 2
R:R:Q184 R:R:Y179 2.25 0 No Yes 3 5 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.08
Average Nodes In Shell21.00
Average Hubs In Shell15.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XW9 A Peptide Thyrotropin-releasing hormone TRH Homo sapiens TRH - chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2 2.7 2022-12-28 10.1038/s41421-022-00477-0

A 2D representation of the interactions of PCA in 7XW9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q105 R:R:T102 5.67 1 Yes Yes 7 4 2 2
R:R:L164 R:R:T102 11.79 1 Yes Yes 5 4 2 2
L:L:H2 R:R:T102 5.48 1 Yes Yes 0 4 1 2
L:L:H2 R:R:Q105 3.71 1 Yes Yes 0 7 1 2
L:L:P3 R:R:Q105 12.63 1 Yes Yes 0 7 1 2
L:L:?4 R:R:Q105 9.95 1 Yes Yes 0 7 2 2
R:R:I109 R:R:Y106 3.63 1 Yes Yes 7 5 2 1
R:R:W160 R:R:Y106 33.76 1 Yes Yes 5 5 2 1
R:R:Y106 R:R:Y192 3.97 1 Yes Yes 5 5 1 1
R:R:Y106 R:R:Y282 2.98 1 Yes Yes 5 5 1 1
L:L:?1 R:R:Y106 3.74 1 Yes Yes 0 5 0 1
L:L:H2 R:R:Y106 10.89 1 Yes Yes 0 5 1 1
L:L:P3 R:R:Y106 11.13 1 Yes Yes 0 5 1 1
L:L:P3 R:R:I109 3.39 1 Yes Yes 0 7 1 2
R:R:L164 R:R:W160 5.69 1 Yes Yes 5 5 2 2
R:R:W160 R:R:Y188 3.86 1 Yes Yes 5 5 2 2
R:R:W160 R:R:Y192 7.72 1 Yes Yes 5 5 2 1
L:L:H2 R:R:L164 6.43 1 Yes Yes 0 5 1 2
R:R:G180 R:R:Y181 2.9 0 No Yes 3 4 2 1
R:R:R185 R:R:Y181 15.43 1 Yes Yes 2 4 1 1
R:R:Y181 R:R:Y188 12.91 1 Yes Yes 4 5 1 2
R:R:Y181 R:R:Y192 5.96 1 Yes Yes 4 5 1 1
L:L:?1 R:R:Y181 8.73 1 Yes Yes 0 4 0 1
L:L:H2 R:R:Y181 5.44 1 Yes Yes 0 4 1 1
R:R:R185 R:R:Y192 7.2 1 Yes Yes 2 5 1 1
R:R:N289 R:R:R185 6.03 1 Yes Yes 4 2 1 1
L:L:?1 R:R:R185 11.64 1 Yes Yes 0 2 0 1
R:R:Y188 R:R:Y192 2.98 1 Yes Yes 5 5 2 1
R:R:V286 R:R:Y192 10.09 1 No Yes 6 5 1 1
L:L:?1 R:R:Y192 3.74 1 Yes Yes 0 5 0 1
R:R:V286 R:R:Y282 8.83 1 No Yes 6 5 1 1
R:R:C305 R:R:Y282 2.69 1 Yes Yes 5 5 2 1
R:R:I309 R:R:Y282 7.25 0 No Yes 6 5 2 1
L:L:?1 R:R:Y282 6.24 1 Yes Yes 0 5 0 1
L:L:P3 R:R:Y282 11.13 1 Yes Yes 0 5 1 1
R:R:L285 R:R:N289 5.49 1 Yes Yes 4 4 2 1
R:R:L285 R:R:L302 2.77 1 Yes Yes 4 4 2 1
R:R:C305 R:R:L285 3.17 1 Yes Yes 5 4 2 2
L:L:?1 R:R:V286 6.34 1 Yes No 0 6 0 1
R:R:N289 R:R:P295 8.15 1 Yes No 4 1 1 2
L:L:?1 R:R:N289 7.31 1 Yes Yes 0 4 0 1
R:R:L302 R:R:R306 3.64 0 Yes No 4 5 1 2
L:L:?1 R:R:L302 4.42 1 Yes Yes 0 4 0 1
L:L:?1 L:L:H2 9.58 1 Yes Yes 0 0 0 1
L:L:?1 L:L:P3 3.5 1 Yes Yes 0 0 0 1
L:L:H2 L:L:P3 4.58 1 Yes Yes 0 0 1 1
L:L:?4 L:L:P3 12.28 1 Yes Yes 0 0 2 1
R:R:L302 R:R:Q297 2.66 0 Yes No 4 3 1 2
R:R:L292 R:R:N289 1.37 0 No Yes 4 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub9.00
Average Interaction Strength6.52
Average Nodes In Shell26.00
Average Hubs In Shell19.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell49.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XZG A Peptide Apelin Apelin Homo sapiens Apelin-13 - Gi1/Beta1/Gamma2 3.2 2024-03-20 10.1016/j.cell.2024.02.004

A 2D representation of the interactions of PCA in 8XZG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:P3 6.99 0 No No 0 0 0 1
L:L:?1 R:R:D284 5.78 0 No No 0 4 0 1
L:L:?1 R:R:L285 5.89 0 No No 0 3 0 1
R:R:D284 R:R:Y271 9.2 25 No Yes 4 4 1 2
R:R:M288 R:R:Y271 17.96 25 No Yes 4 4 2 2
R:R:C281 R:R:L285 3.17 0 No No 8 3 2 1
R:R:D284 R:R:M288 2.77 25 No No 4 4 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub0.00
Average Interaction Strength6.22
Average Nodes In Shell7.00
Average Hubs In Shell1.00
Average Links In Shell7.00
Average Links Mediated by Hubs In Shell2.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links5.64
Average Number Of Links With An Hub3.14
Average Interaction Strength6.49
Average Nodes In Shell16.57
Average Hubs In Shell9.07
Average Links In Shell23.79
Average Links Mediated by Hubs In Shell21.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)