Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L41 4.4547
2A:A:R42 5.71529
3A:A:L44 6.89429
4A:A:L46 6.1725428
5A:A:N50 8.3385146
6A:A:K53 5.576549
7A:A:F219 7.628548
8A:A:H220 11.445427
9A:A:F222 8.906527
10A:A:Q227 7.54529
11A:A:R228 8.16167629
12A:A:K233 7.155829
13A:A:W234 8.804529
14A:A:F238 7.65629
15A:A:D240 6.0325426
16A:A:I244 4.906528
17A:A:F246 4.4275409
18A:A:D249 12.00754148
19A:A:Y253 9.795228
20A:A:L270 5.8406
21A:A:D272 5.24428
22A:A:F273 5.226509
23A:A:I276 4.785428
24A:A:W277 9.6256236
25A:A:W281 6.832525
26A:A:L282 5.985429
27A:A:L289 4.9575479
28A:A:F290 6.5825449
29A:A:L291 4.5725478
30A:A:N292 5.3975449
31A:A:Y311 8.665406
32A:A:F315 12.98754106
33A:A:Y318 4.514106
34A:A:P321 4.0545105
35A:A:E330 6.118573
36A:A:V334 4.1275474
37A:A:K338 11.22475
38A:A:F340 10.9854107
39A:A:F345 6.92578
40A:A:C359 3.2925405
41A:A:Y360 9.995408
42A:A:F363 9.6025475
43A:A:T364 6.796549
44A:A:N371 8.264549
45A:A:R373 6.3275445
46A:A:F376 6.67448
47A:A:I382 3.8825406
48A:A:I383 2.98448
49A:A:Y391 5.815114
50B:B:R22 8.58456
51B:B:D27 6.82408
52B:B:L30 4.37405
53B:B:V40 4.123336173
54B:B:H54 11.2125409
55B:B:K57 10.904529
56B:B:Y59 7.9575428
57B:B:M61 3.732536
58B:B:W63 5.295637
59B:B:V71 3.975488
60B:B:Q75 6.91833629
61B:B:D76 6.09409
62B:B:K78 5.7325408
63B:B:I81 4.705487
64B:B:W82 9.70571739
65B:B:D83 8.87438
66B:B:Y85 13.09434
67B:B:N88 5.07437
68B:B:K89 7.83714739
69B:B:H91 5.62405
70B:B:I93 6.2487
71B:B:W99 8.36833629
72B:B:Y105 4.43571786
73B:B:N110 6.534184
74B:B:Y111 5.9165184
75B:B:C114 4.765488
76B:B:C121 3.73754128
77B:B:I123 3.2975406
78B:B:Y124 5.815686
79B:B:T128 2.9875403
80B:B:V133 6.8675484
81B:B:H142 6.8185129
82B:B:Y145 8.416528
83B:B:L146 4.96254127
84B:B:F151 4.46667609
85B:B:L152 5.182563
86B:B:I157 4.3725407
87B:B:T159 6.62254129
88B:B:L168 4.024566
89B:B:W169 8.261437128
90B:B:Q176 7.33754124
91B:B:F180 7.34567
92B:B:H183 8.6569
93B:B:D186 6.91167629
94B:B:V187 4.148569
95B:B:F199 7.6775469
96B:B:V200 6.9125456
97B:B:S201 4.6075469
98B:B:C204 5.578527
99B:B:D205 6.595469
100B:B:S207 4.2375465
101B:B:K209 8.952566
102B:B:L210 4.795455
103B:B:W211 8.18668
104B:B:D212 8.0975459
105B:B:F222 9.165458
106B:B:H225 8.54167659
107B:B:D228 7.2075429
108B:B:I232 5.0975458
109B:B:F234 5.735405
110B:B:F235 6.245896
111B:B:P236 6.0025497
112B:B:F241 7.37556
113B:B:T243 5.1775458
114B:B:D246 6.126529
115B:B:D247 6.935459
116B:B:T249 6.4925456
117B:B:R251 11.384558
118B:B:F253 8.546556
119B:B:D254 4.914269
120B:B:R256 7.9075409
121B:B:D258 12.0175457
122B:B:E260 9.0925456
123B:B:L261 4.22754265
124B:B:M262 3.7975404
125B:B:T263 5.5825451
126B:B:Y264 6.038505
127B:B:F278 4.77697
128B:B:R283 9.184179
129B:B:L284 3.63405
130B:B:Y289 7.001676157
131B:B:D290 5.38426
132B:B:N295 7.8125156
133B:B:W297 6.8054158
134B:B:L300 5.4625406
135B:B:K301 4.252505
136B:B:R304 7.2154155
137B:B:H311 8.8325139
138B:B:R314 11.098528
139B:B:L318 4.0354276
140B:B:M325 5.6435
141B:B:V327 4.18254276
142B:B:W332 9.96286729
143B:B:D333 8.86754139
144B:B:L336 4.01833637
145B:B:K337 8.75136
146B:B:W339 9.455139
147G:G:I9 3.855402
148G:G:K20 4.26254256
149G:G:R27 5.3125458
150G:G:Y40 7.185496
151G:G:D48 5.816509
152G:G:P49 3.52407
153G:G:L51 3.673336176
154G:G:N59 5.626539
155G:G:P60 8.23439
156G:G:F61 5.3125838
157L:L:?1 13.2271710
158L:L:H2 7.49833610
159L:L:W3 10.8675810
160L:L:Y5 8.00714710
161L:L:?11 7.3075410
162R:R:R56 9.05667614
163R:R:N71 7.5025169
164R:R:Y82 5.194116
165R:R:H87 5.917117
166R:R:I88 8.324118
167R:R:L91 5.5254117
168R:R:D99 7.7654169
169R:R:F101 6.225406
170R:R:I102 5.3875407
171R:R:V106 4.935417
172R:R:M107 5.3175417
173R:R:D110 5.2525416
174R:R:W113 15.7975415
175R:R:W119 8.64718
176R:R:R127 6.7475407
177R:R:F131 5.4675406
178R:R:L134 7.1175414
179R:R:Y138 6.526516
180R:R:D150 7.7354118
181R:R:P158 3.32547
182R:R:L159 3.222546
183R:R:I161 4.925405
184R:R:M171 3.9925405
185R:R:L172 5.96407
186R:R:W176 4.4875409
187R:R:Y180 4.446503
188R:R:Q186 7.1825414
189R:R:F190 7.904515
190R:R:T206 5.896514
191R:R:F210 7.078514
192R:R:Q215 7.8625413
193R:R:M221 5.784514
194R:R:F224 6.565415
195R:R:F228 5.7925418
196R:R:P231 3.305409
197R:R:M235 4.38518
198R:R:Y239 6.672519
199R:R:R241 6.0175404
200R:R:I269 4.3454194
201R:R:I283 4.4325418
202R:R:F287 4.8875419
203R:R:W291 5.14618
204R:R:Y294 10.64616
205R:R:Y295 6.49717
206R:R:L297 4.318514
207R:R:W302 10.0933614
208R:R:M307 7.4675413
209R:R:L308 7.6475411
210R:R:V313 3.96714715
211R:R:H319 5.074514
212R:R:L321 6.015416
213R:R:F322 8.315615
214R:R:N328 5.9375409
215R:R:P333 4.4354169
216R:R:I335 3.858508
217R:R:Y336 4.7925409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:N387 R:R:I161 21.77779.91NoYes085
2A:A:I383 A:A:N387 84.04712.83YesNo088
3A:A:I383 A:A:L41 85.25922.85YesYes487
4A:A:F219 A:A:L41 87.11317.31YesYes487
5A:A:F219 A:A:L43 88.64554.87YesNo487
6A:A:I375 A:A:L43 88.4972.85NoNo497
7A:A:F290 A:A:I375 88.74615.02YesNo499
8A:A:F290 A:A:T364 93.38739.08YesYes499
9A:A:N292 A:A:T364 94.23597.31YesYes499
10A:A:K293 A:A:N292 96.85815.6NoYes099
11A:A:D249 A:A:K293 97.239416.59YesNo089
12A:A:D249 A:A:N50 97.812910.77YesYes1486
13A:A:N50 A:A:R265 98.650115.67YesNo1469
14A:A:N254 A:A:R265 98.88466.03NoNo099
15A:A:F312 A:A:N254 98.98642.42NoNo089
16A:A:F312 A:A:Y253 99.08812.06NoYes088
17A:A:Y253 A:A:Y311 99.696818.86YesYes086
18A:A:F315 A:A:Y311 1009.28YesYes066
19A:A:F315 A:A:F340 99.295522.51YesYes1067
20A:A:E344 A:A:F340 99.757210.49NoYes1057
21A:A:E344 A:A:L270 99.98867.95NoYes056
22A:A:F345 A:A:L270 66.83329.74YesYes086
23A:A:F273 A:A:F345 33.63238.57YesYes098
24A:A:F246 A:A:F273 67.28073.22YesYes099
25A:A:F246 A:A:L46 80.14124.87YesYes098
26A:A:L44 A:A:L46 53.84315.54YesYes298
27A:A:L44 A:A:W234 21.46444.56YesYes299
28A:A:V224 A:A:W234 42.60217.36NoYes099
29A:A:Q227 A:A:V224 42.4025.73YesNo099
30A:A:Q227 B:B:Y145 42.052610.15YesYes298
31B:B:G162 B:B:Y145 60.07497.24NoYes298
32B:B:G162 B:B:S161 60.89283.71NoNo099
33B:B:H142 B:B:S161 59.267813.95YesNo099
34B:B:H142 B:B:T159 48.68998.21YesYes1299
35B:B:L146 B:B:T159 47.81438.84YesYes1279
36A:A:I348 A:A:L270 33.55772.85NoYes046
37A:A:F273 A:A:I348 33.58177.54YesNo094
38A:A:F345 A:A:L289 33.27456.09YesYes789
39A:A:F246 A:A:L289 34.73573.65YesYes099
40A:A:D272 A:A:F246 21.81965.97YesYes089
41A:A:D272 A:A:R231 21.574810.72YesNo289
42A:A:R231 A:A:W234 21.513113NoYes299
43A:A:F238 A:A:L44 32.340414.61YesYes299
44A:A:C237 A:A:F238 27.25972.79NoYes089
45A:A:C237 B:B:M101 21.91924.86NoNo089
46B:B:M101 B:B:Y145 21.71617.18NoYes098
47B:B:S316 B:B:W332 10.48593.71NoYes099
48A:A:N279 A:A:W281 25.47275.65NoYes285
49A:A:L282 A:A:N279 25.43828.24YesNo298
50A:A:N387 R:R:A154 62.15963.13NoNo088
51A:A:Y391 R:R:A154 62.04245.34YesNo048
52R:R:H87 R:R:I161 20.97085.3YesYes075
53A:A:Y391 R:R:R151 51.48015.14YesNo049
54B:B:C148 B:B:L190 38.146.35NoNo065
55B:B:F199 B:B:L190 34.26824.87YesNo095
56B:B:F199 B:B:W211 27.539812.03YesYes698
57B:B:K209 B:B:W211 25.33365.8YesYes668
58B:B:K209 B:B:T221 24.392815.02YesNo667
59B:B:T221 G:G:E22 24.08582.82NoNo079
60B:B:I18 G:G:E22 20.857310.93NoNo079
61B:B:I18 B:B:R22 19.56366.26NoYes076
62B:B:D258 B:B:R22 17.613916.68YesYes576
63B:B:C148 B:B:T102 40.87393.38NoNo068
64B:B:L146 B:B:T102 40.50734.42YesNo078
65B:B:D258 B:B:F222 16.64384.78YesYes578
66B:B:D290 B:B:R314 10.289510.72YesYes268
67B:B:C271 B:B:D290 10.09233.11NoYes056
68B:B:L318 B:B:S275 11.17756.01YesNo068
69B:B:S275 B:B:T274 11.29773.2NoNo088
70R:R:R151 R:R:Y239 46.17897.2NoYes099
71R:R:M235 R:R:Y239 41.0063.59YesYes189
72R:R:F287 R:R:M235 41.1566.22YesYes198
73R:R:F287 R:R:W291 29.98824.01YesYes198
74R:R:W291 R:R:Y294 20.79663.86YesYes186
75R:R:F228 R:R:F287 10.32116.43YesYes189
76L:L:H2 R:R:Y295 12.65786.53YesYes107
77L:L:H2 R:R:L134 17.99123.86YesYes104
78R:R:L134 R:R:Q186 17.141511.98YesYes144
79R:R:D150 R:R:L91 18.61255.43YesYes1187
80R:R:I147 R:R:L91 11.89024.28NoYes097
81R:R:I147 R:R:L95 11.48785.71NoNo099
82R:R:L95 R:R:Y336 11.15054.69NoYes099
83R:R:D332 R:R:Y336 17.23973.45NoYes099
84R:R:D332 R:R:D99 16.53423.99NoYes099
85R:R:L172 R:R:L91 15.65564.15YesYes077
86R:R:L172 R:R:N94 14.055913.73YesNo079
87R:R:N94 R:R:W176 12.83565.65NoYes099
88R:R:W176 R:R:Y180 10.81184.82YesYes093
89A:A:I244 A:A:L282 25.60325.71YesYes289
90B:B:R314 B:B:T274 11.347412.94YesNo288
91A:A:I244 A:A:L46 26.13767.14YesYes288
92A:A:W281 B:B:R314 20.3395YesYes258
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:R56 3.9 1 Yes Yes 0 4 0 1
L:L:?1 R:R:K133 4.53 1 Yes No 0 6 0 1
L:L:?1 R:R:Y294 17.56 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F322 20.85 1 Yes Yes 0 5 0 1
L:L:H2 R:R:L134 3.86 1 Yes Yes 0 4 0 1
L:L:H2 R:R:M137 6.57 1 Yes No 0 7 0 1
L:L:H2 R:R:Y294 10.89 1 Yes Yes 0 6 0 1
L:L:H2 R:R:Y295 6.53 1 Yes Yes 0 7 0 1
L:L:W3 R:R:N220 3.39 1 Yes No 0 4 0 1
L:L:W3 R:R:Y294 17.36 1 Yes Yes 0 6 0 1
L:L:W3 R:R:G298 4.22 1 Yes No 0 5 0 1
L:L:W3 R:R:W302 16.87 1 Yes Yes 0 4 0 1
L:L:W3 R:R:F322 4.01 1 Yes Yes 0 5 0 1
L:L:S4 R:R:A205 3.42 0 No No 0 1 0 1
L:L:S4 R:R:T206 6.4 0 No Yes 0 4 0 1
L:L:Y5 R:R:Y301 10.92 1 Yes No 0 3 0 1
L:L:Y5 R:R:M307 8.38 1 Yes Yes 0 3 0 1
L:L:Y5 R:R:L308 17.58 1 Yes Yes 0 1 0 1
L:L:Y5 R:R:V313 3.79 1 Yes Yes 0 5 0 1
L:L:Y5 R:R:S318 6.36 1 Yes No 0 4 0 1
L:L:Y5 R:R:F322 5.16 1 Yes Yes 0 5 0 1
L:L:G6 R:R:L308 3.42 0 No Yes 0 1 0 1
L:L:L7 R:R:V193 2.98 0 No No 0 1 0 1
L:L:L7 R:R:Q203 10.65 0 No No 0 4 0 1
L:L:L7 R:R:A205 3.15 0 No No 0 1 0 1
L:L:R8 R:R:L308 6.07 0 No Yes 0 1 0 1
L:L:R8 R:R:P315 5.76 0 No No 0 4 0 1
L:L:P9 R:R:W113 5.4 1 No Yes 0 5 0 1
L:L:P9 R:R:L117 11.49 1 No No 0 5 0 1
L:L:P9 R:R:Q203 9.47 1 No No 0 4 0 1
L:L:?11 R:R:D110 3.36 1 Yes Yes 0 6 0 1
L:L:?11 R:R:K133 6.98 1 Yes No 0 6 0 1
R:R:D110 R:R:R56 10.72 1 Yes Yes 6 4 1 1
R:R:N114 R:R:R56 9.64 1 No Yes 4 4 2 1
R:R:H319 R:R:R56 10.16 1 Yes Yes 4 4 2 1
R:R:F322 R:R:R56 5.34 1 Yes Yes 5 4 1 1
R:R:L323 R:R:R56 14.58 0 No Yes 5 4 2 1
R:R:D110 R:R:T60 2.89 1 Yes No 6 6 1 2
R:R:L323 R:R:T60 2.95 0 No No 5 6 2 2
R:R:I102 R:R:V106 7.68 0 Yes Yes 7 7 2 2
R:R:I102 R:R:M137 2.92 0 Yes No 7 7 2 1
R:R:K133 R:R:V106 4.55 1 No Yes 6 7 1 2
R:R:D110 R:R:N114 4.04 1 Yes No 6 4 1 2
R:R:W113 R:R:W119 29.05 1 Yes Yes 5 8 1 2
R:R:M130 R:R:W113 4.65 1 No Yes 5 5 2 1
R:R:Q203 R:R:W113 24.09 1 No Yes 4 5 1 1
R:R:H319 R:R:N114 5.1 1 Yes No 4 4 2 2
R:R:M130 R:R:Q186 4.08 1 No Yes 5 4 2 2
R:R:F190 R:R:M130 14.93 1 Yes No 5 5 2 2
R:R:L134 R:R:Y138 8.21 1 Yes Yes 4 6 1 2
R:R:L134 R:R:Q186 11.98 1 Yes Yes 4 4 1 2
R:R:L134 R:R:T223 4.42 1 Yes No 4 4 1 2
R:R:L227 R:R:M137 5.65 0 No No 5 7 2 1
R:R:T223 R:R:Y138 7.49 1 No Yes 4 6 2 2
R:R:L227 R:R:Y138 9.38 0 No Yes 5 6 2 2
R:R:F190 R:R:Q186 7.03 1 Yes Yes 5 4 2 2
R:R:T206 R:R:V189 3.17 1 Yes No 4 4 1 2
R:R:F210 R:R:V189 11.8 1 Yes No 4 4 2 2
R:R:F190 R:R:T206 7.78 1 Yes Yes 5 4 2 1
R:R:F210 R:R:T206 6.49 1 Yes Yes 4 4 2 1
R:R:E216 R:R:T206 5.64 1 No Yes 4 4 2 1
R:R:E216 R:R:F210 9.33 1 No Yes 4 4 2 2
R:R:N220 R:R:W302 23.73 1 No Yes 4 4 1 1
R:R:F224 R:R:M221 7.46 1 Yes Yes 5 4 2 2
R:R:M221 R:R:W302 4.65 1 Yes Yes 4 4 2 1
R:R:F224 R:R:F228 8.57 1 Yes Yes 5 8 2 2
R:R:F224 R:R:Y295 7.22 1 Yes Yes 5 7 2 1
R:R:F224 R:R:W302 3.01 1 Yes Yes 5 4 2 1
R:R:L227 R:R:Y295 7.03 0 No Yes 5 7 2 1
R:R:F228 R:R:W291 3.01 1 Yes Yes 8 8 2 2
R:R:F228 R:R:Y295 5.16 1 Yes Yes 8 7 2 1
R:R:W291 R:R:Y294 3.86 1 Yes Yes 8 6 2 1
R:R:W291 R:R:Y295 8.68 1 Yes Yes 8 7 2 1
R:R:Y294 R:R:Y295 6.95 1 Yes Yes 6 7 1 1
R:R:F322 R:R:Y294 7.22 1 Yes Yes 5 6 1 1
R:R:W302 R:R:Y295 3.86 1 Yes Yes 4 7 1 1
R:R:L297 R:R:V313 2.98 1 Yes Yes 4 5 2 1
R:R:L297 R:R:S318 3 1 Yes No 4 4 2 1
R:R:F322 R:R:L297 7.31 1 Yes Yes 5 4 1 2
R:R:G298 R:R:W302 8.44 1 No Yes 5 4 1 1
R:R:M307 R:R:W300 13.96 1 Yes No 3 4 1 2
R:R:V313 R:R:W300 3.68 1 Yes No 5 4 1 2
R:R:P305 R:R:Y301 5.56 0 No No 3 3 2 1
R:R:L308 R:R:Y301 3.52 1 Yes No 1 3 1 1
R:R:M307 R:R:V313 6.09 1 Yes Yes 3 5 1 1
R:R:P314 R:R:V313 3.53 1 No Yes 5 5 2 1
R:R:L317 R:R:V313 4.47 1 No Yes 5 5 2 1
R:R:S318 R:R:V313 3.23 1 No Yes 4 5 1 1
R:R:L317 R:R:P314 4.93 1 No No 5 5 2 2
R:R:K312 R:R:M307 1.44 0 No Yes 3 3 2 1
L:L:R8 R:R:E311 1.16 0 No No 0 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
3.03Single8HTIOcatnoic acid8HTI-OR52C-Ocatnoic acid-Gs/β1/γ2

PDB Summary
PDB 9U4Y
Class A
SubFamily Peptide
Type Gonadotrophin Releasing Hormone
SubType GnRH1
Species Xenopus Laevis
Ligand Gonadoliberin-1
Other Ligand(s) -
Protein Partners chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.18
Date 2025-06-11 
D.O.I. doi.org/10.1073/pnas.2500112122
Net Summary
Imin 2.77
Number of Linked Nodes 839
Number of Links 1101
Number of Hubs 217
Number of Links mediated by Hubs 765
Number of Communities 28
Number of Nodes involved in Communities 319
Number of Links involved in Communities 482
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 2914168
Length Of Smallest Path 3
Average Path Length 43.0203
Length of Longest Path 70
Minimum Path Strength 1.38
Average Path Strength 7.29218
Maximum Path Strength 26.57
Minimum Path Correlation 0.7
Average Path Correlation 0.988443
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 29.5476
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 62.0361
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodePCA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodePCA
NamePidolic acid
SynonymsL-pyroglutamic acid
Identifier
FormulaC5 H7 N O3
Molecular Weight129.114
SMILES
PubChem7405
Formal Charge0
Total Atoms16
Total Chiral Atoms1
Total Bonds16
Total Aromatic Bonds0

CodeNH2
PDB ResiduesL:L:?11
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier
FormulaH2 N
Molecular Weight16.023
SMILES
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9U4Y_Chain_A
EKAEKIKLD RTRLLLLGA SGKSTIVKI FETKFQVDK VNFHMFDVG 
GQRDERRKW IQCFNDVTA IIFVVSSYN RLQEALNFK SIWNNRWLR 
TISVILFLN KQDLLAEKV SKIEDYFPE FARYTTPED ATPEPGEDP 
RVTRAKYFI REFISTASG DGRHCYPHF TCAVDTENR RFNDCDIIM 
LRYLDAARS MDNREGEKA RLDNDDDKV DIAIKLQNE N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9U4Y_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9U4Y_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ90WJ2
Sequence
>9U4Y_Chain_R
STAAKIRVA ITCVLFIFS ACFNIAALW TITYKYKKK SHIRILIIN 
LVAADLFIT LVVMPLDAV WNVTLQWYA GDLACRVLM FLKLAAMYS 
SAFVTVVIS LDRQAAILN PLGIGDAKK KNKIMLCVA WFLSYLLAI 
PQLFVFHTV SRQCATVGS FQAHWQETI YNMFTFFCL FLLPLLIMV 
SCYTRILME ISHKNIPRA RMRTLKMSL VIVLTFIVC WTPYYLLGI 
WYWFSPEML TEEKVPPSL SHILFLFGL LNTCLDPII YGL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7BR3APeptideGonadotrophin Releasing HormoneGnRH1Homo sapiensElagolix--2.792020-10-07doi.org/10.1038/s41467-020-19109-w
9U4WAPeptideGonadotrophin Releasing HormoneGnRH1Sus scrofaGonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ23.182025-06-11doi.org/10.1073/pnas.2500112122
9U4W (No Gprot) APeptideGonadotrophin Releasing HormoneGnRH1Sus scrofaGonadoliberin-1-3.182025-06-11doi.org/10.1073/pnas.2500112122
9U4Y (No Gprot) APeptideGonadotrophin Releasing HormoneGnRH1Xenopus laevisGonadoliberin-1-3.182025-06-11doi.org/10.1073/pnas.2500112122




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