psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	5.5	Yes	Yes	1	0	0
2	L:L:?1	L:L:W3	25.59	Yes	Yes	1	0	0
3	L:L:?1	L:L:?11	14.66	Yes	No	1	0	0
4	L:L:?1	R:R:K133	4.53	Yes	No	1	0	6
5	L:L:?1	R:R:Y294	17.56	Yes	Yes	1	0	6
6	L:L:?1	R:R:F322	20.85	Yes	Yes	1	0	5
7	L:L:H2	L:L:W3	11.64	Yes	Yes	1	0	0
8	L:L:H2	R:R:M137	6.57	Yes	No	0	0	7
9	L:L:H2	R:R:Y294	10.89	Yes	Yes	1	0	6
10	L:L:H2	R:R:Y295	6.53	Yes	Yes	1	0	7
11	L:L:W3	R:R:Y294	17.36	Yes	Yes	1	0	6
12	L:L:W3	R:R:G298	4.22	Yes	No	1	0	5
13	L:L:W3	R:R:W302	16.87	Yes	Yes	1	0	4
14	L:L:S4	R:R:T206	6.4	No	Yes	0	0	4
15	L:L:Y5	R:R:Y301	10.92	Yes	No	0	0	3
16	L:L:Y5	R:R:M307	8.38	Yes	Yes	0	0	3
17	L:L:Y5	R:R:L308	17.58	Yes	No	0	0	1
18	L:L:Y5	R:R:S318	6.36	Yes	No	0	0	4
19	L:L:Y5	R:R:F322	5.16	Yes	Yes	0	0	5
20	L:L:L7	R:R:Q203	10.65	No	No	0	0	4
21	L:L:R8	R:R:L308	6.07	No	No	0	0	1
22	L:L:R8	R:R:P315	5.76	No	No	0	0	4
23	L:L:P9	R:R:W113	5.4	No	Yes	3	0	5
24	L:L:P9	R:R:L117	11.49	No	No	0	0	5
25	L:L:P9	R:R:Q203	9.47	No	No	3	0	4
26	L:L:?11	L:L:G10	4.23	No	No	0	0	0
27	L:L:?11	R:R:K133	6.98	No	No	1	0	6
28	R:R:A53	R:R:H319	5.85	No	Yes	0	4	4
29	R:R:D110	R:R:R56	10.72	No	Yes	0	6	4
30	R:R:N114	R:R:R56	9.64	No	Yes	1	4	4
31	R:R:H319	R:R:R56	10.16	Yes	Yes	1	4	4
32	R:R:F322	R:R:R56	5.34	Yes	Yes	1	5	4
33	R:R:L323	R:R:R56	14.58	No	Yes	0	5	4
34	R:R:I59	R:R:L323	4.28	No	No	0	5	5
35	R:R:F66	R:R:V62	5.24	No	No	0	6	5
36	R:R:F64	R:R:T103	5.19	No	No	0	6	6
37	R:R:F64	R:R:M107	4.98	No	No	0	6	7
38	R:R:S67	R:R:T103	7.99	No	No	0	8	6
39	R:R:N71	R:R:V96	7.39	Yes	No	0	9	9
40	R:R:D99	R:R:N71	12.12	No	Yes	4	9	9
41	R:R:L100	R:R:N71	6.87	No	Yes	0	7	9
42	R:R:N71	R:R:P333	8.15	Yes	Yes	4	9	9
43	R:R:T79	R:R:W76	4.85	No	No	5	4	4
44	R:R:W76	R:R:Y80	12.54	No	No	5	4	5
45	R:R:I78	R:R:R89	6.26	No	No	0	7	8
46	R:R:I78	R:R:I92	4.42	No	No	0	7	8
47	R:R:T79	R:R:Y80	6.24	No	No	5	4	5
48	R:R:R89	R:R:T79	6.47	No	No	0	8	4
49	R:R:S86	R:R:Y82	5.09	No	Yes	0	8	6
50	R:R:I88	R:R:Y82	8.46	No	Yes	0	8	6
51	R:R:H87	R:R:I88	13.26	Yes	No	0	7	8
52	R:R:D150	R:R:H87	6.3	No	Yes	0	8	7
53	R:R:H87	R:R:I161	5.3	Yes	No	0	7	5
54	R:R:A164	R:R:H87	4.39	No	Yes	0	7	7
55	R:R:I147	R:R:L91	4.28	No	Yes	0	9	7
56	R:R:D150	R:R:L91	5.43	No	Yes	6	8	7
57	R:R:L91	R:R:N168	8.24	Yes	No	6	7	7
58	R:R:L172	R:R:L91	4.15	No	Yes	0	7	7
59	R:R:I93	R:R:N94	4.25	No	No	0	6	9
60	R:R:L172	R:R:N94	13.73	No	No	0	7	9
61	R:R:N94	R:R:W176	5.65	No	Yes	0	9	9
62	R:R:L95	R:R:V143	5.96	No	No	0	9	8
63	R:R:I147	R:R:L95	5.71	No	No	0	9	9
64	R:R:L95	R:R:Y336	4.69	No	No	0	9	9
65	R:R:D99	R:R:T329	10.12	No	No	0	9	8
66	R:R:D99	R:R:P333	4.83	No	Yes	4	9	9
67	R:R:F101	R:R:V105	6.55	Yes	No	0	6	5
68	R:R:F101	R:R:L132	4.87	Yes	No	0	6	5
69	R:R:A136	R:R:F101	8.32	No	Yes	0	8	6
70	R:R:F101	R:R:Y180	5.16	Yes	Yes	0	6	3
71	R:R:I102	R:R:V106	7.68	No	No	0	7	7
72	R:R:A136	R:R:I102	4.87	No	No	0	8	7
73	R:R:I102	R:R:T329	6.08	No	No	0	7	8
74	R:R:K133	R:R:V106	4.55	No	No	0	6	7
75	R:R:L326	R:R:V106	4.47	No	No	0	7	7
76	R:R:L326	R:R:M107	9.9	No	No	0	7	7
77	R:R:L109	R:R:L129	8.3	No	No	0	6	5
78	R:R:W113	R:R:W119	29.05	Yes	Yes	0	5	8
79	R:R:M130	R:R:W113	4.65	No	Yes	0	5	5
80	R:R:Q203	R:R:W113	24.09	No	Yes	3	4	5
81	R:R:H319	R:R:N114	5.1	Yes	No	1	4	4
82	R:R:T116	R:R:V115	4.76	No	No	0	5	5
83	R:R:A121	R:R:W119	5.19	No	Yes	0	7	8
84	R:R:C126	R:R:W119	10.45	No	Yes	0	9	8
85	R:R:L129	R:R:W119	4.56	No	Yes	0	5	8
86	R:R:D123	R:R:R127	13.1	No	Yes	0	3	7
87	R:R:D123	R:R:T192	8.67	No	No	0	3	6
88	R:R:C126	R:R:F190	4.19	No	Yes	2	9	5
89	R:R:C126	R:R:C204	7.28	No	No	2	9	9
90	R:R:H191	R:R:R127	9.03	No	Yes	0	4	7
91	R:R:F190	R:R:M130	14.93	Yes	No	0	5	5
92	R:R:F131	R:R:L132	6.09	No	No	0	6	5
93	R:R:A183	R:R:F131	4.16	No	No	0	7	6
94	R:R:F131	R:R:L187	8.53	No	No	0	6	5
95	R:R:L134	R:R:Y138	8.21	No	Yes	7	4	6
96	R:R:L134	R:R:Q186	11.98	No	No	0	4	4
97	R:R:L134	R:R:T223	4.42	No	No	7	4	4
98	R:R:A135	R:R:Y180	5.34	No	Yes	0	5	3
99	R:R:L227	R:R:M137	5.65	No	No	0	5	7
100	R:R:T223	R:R:Y138	7.49	No	Yes	7	4	6
101	R:R:L227	R:R:Y138	9.38	No	Yes	0	5	6
102	R:R:S139	R:R:W176	6.18	No	Yes	0	7	9
103	R:R:F142	R:R:L178	7.31	No	No	0	6	3
104	R:R:T144	R:R:Y336	4.99	No	No	0	8	9
105	R:R:I234	R:R:V145	4.61	No	No	0	6	7
106	R:R:M235	R:R:S148	6.13	No	No	0	8	9
107	R:R:S148	R:R:Y239	6.36	No	Yes	0	9	9
108	R:R:D150	R:R:N168	13.46	No	No	6	8	7
109	R:R:R151	R:R:Y239	7.2	No	Yes	0	9	9
110	R:R:M279	R:R:R151	6.2	No	No	0	8	9
111	R:R:C238	R:R:Q152	13.74	No	No	0	7	8
112	R:R:Q152	R:R:R241	12.85	No	Yes	0	8	4
113	R:R:I155	R:R:I242	8.83	No	No	0	8	8
114	R:R:L156	R:R:R241	7.29	No	Yes	0	7	4
115	R:R:K167	R:R:M171	8.64	No	No	0	4	5
116	R:R:W176	R:R:Y180	4.82	Yes	Yes	0	9	3
117	R:R:F177	R:R:L181	6.09	No	No	0	4	4
118	R:R:L178	R:R:L182	5.54	No	No	0	3	4
119	R:R:P185	R:R:Y219	5.56	No	No	0	7	5
120	R:R:F190	R:R:Q186	7.03	Yes	No	0	5	4
121	R:R:Q186	R:R:Y219	5.64	No	No	0	4	5
122	R:R:F210	R:R:V189	11.8	Yes	No	0	4	4
123	R:R:C204	R:R:F190	5.59	No	Yes	2	9	5
124	R:R:F190	R:R:T206	7.78	Yes	Yes	2	5	4
125	R:R:H191	R:R:S209	13.95	No	No	0	4	3
126	R:R:F210	R:R:T206	6.49	Yes	Yes	2	4	4
127	R:R:E216	R:R:T206	5.64	No	Yes	2	4	4
128	R:R:F210	R:R:Q215	4.68	Yes	No	0	4	3
129	R:R:E216	R:R:F210	9.33	No	Yes	2	4	4
130	R:R:Q211	R:R:Q215	5.12	No	No	0	4	3
131	R:R:A212	R:R:W214	5.19	No	No	0	4	1
132	R:R:H213	R:R:T217	6.85	No	No	0	1	1
133	R:R:H213	R:R:P305	12.2	No	No	0	1	3
134	R:R:Q215	R:R:W214	18.62	No	No	0	3	1
135	R:R:N220	R:R:W302	23.73	No	Yes	0	4	4
136	R:R:F224	R:R:M221	7.46	No	Yes	1	5	4
137	R:R:I299	R:R:M221	4.37	No	Yes	1	5	4
138	R:R:M221	R:R:W302	4.65	Yes	Yes	1	4	4
139	R:R:F303	R:R:M221	8.71	No	Yes	1	5	4
140	R:R:C226	R:R:F222	8.38	No	No	0	4	4
141	R:R:F224	R:R:F228	8.57	No	No	1	5	8
142	R:R:F224	R:R:Y295	7.22	No	Yes	1	5	7
143	R:R:L227	R:R:Y295	7.03	No	Yes	0	5	7
144	R:R:F228	R:R:F287	6.43	No	No	0	8	9
145	R:R:F228	R:R:Y295	5.16	No	Yes	1	8	7
146	R:R:L230	R:R:P231	4.93	No	No	0	4	9
147	R:R:I234	R:R:L230	7.14	No	No	0	6	4
148	R:R:I288	R:R:L232	4.28	No	No	0	6	7
149	R:R:F287	R:R:M235	6.22	No	No	0	9	8
150	R:R:S280	R:R:Y239	10.17	No	Yes	0	8	9
151	R:R:I283	R:R:Y239	6.04	No	Yes	0	8	9
152	R:R:L243	R:R:T276	5.9	No	No	0	5	8
153	R:R:L243	R:R:L277	4.15	No	No	0	5	6
154	R:R:E245	R:R:K249	5.4	No	No	0	5	6
155	R:R:I246	R:R:I269	7.36	No	Yes	8	8	4
156	R:R:I269	R:R:R273	5.01	Yes	No	0	4	7
157	R:R:L277	R:R:L281	6.92	No	No	0	6	6
158	R:R:I283	R:R:M279	5.83	No	No	0	8	8
159	R:R:I335	R:R:T286	4.56	Yes	No	0	8	7
160	R:R:I288	R:R:T292	4.56	No	No	0	6	6
161	R:R:C290	R:R:L327	4.76	No	No	0	8	6
162	R:R:W291	R:R:Y295	8.68	No	Yes	0	8	7
163	R:R:G325	R:R:W291	5.63	No	No	0	7	8
164	R:R:N328	R:R:W291	5.65	No	No	0	9	8
165	R:R:L321	R:R:P293	6.57	No	No	0	6	9
166	R:R:F324	R:R:P293	5.78	No	No	0	7	9
167	R:R:Y294	R:R:Y295	6.95	Yes	Yes	1	6	7
168	R:R:F322	R:R:Y294	7.22	Yes	Yes	1	5	6
169	R:R:L297	R:R:L321	6.92	No	No	0	4	6
170	R:R:F322	R:R:L297	7.31	Yes	No	0	5	4
171	R:R:G298	R:R:W302	8.44	No	Yes	1	5	4
172	R:R:F303	R:R:I299	5.02	No	No	1	5	5
173	R:R:M307	R:R:W300	13.96	Yes	No	0	3	4
174	R:R:P305	R:R:Y301	5.56	No	No	0	3	3
175	R:R:M307	R:R:V313	6.09	Yes	No	0	3	5
176	R:R:E310	R:R:K312	6.75	No	No	0	1	3
177	R:R:L317	R:R:V313	4.47	No	No	0	5	5
178	R:R:L317	R:R:P314	4.93	No	No	0	5	5
179	R:R:L317	R:R:L321	6.92	No	No	0	5	6
180	R:R:L327	R:R:L331	4.15	No	No	0	6	6
181	R:R:D332	R:R:N328	13.46	No	No	0	9	9
182	R:R:I335	R:R:L331	4.28	Yes	No	0	8	6
183	R:R:I335	R:R:Y336	6.04	Yes	No	0	8	9
184	R:R:C226	R:R:Y138	4.03	No	Yes	0	4	6
185	R:R:E245	R:R:L156	3.98	No	No	0	5	7
186	R:R:H87	R:R:K165	3.93	Yes	No	0	7	2
187	R:R:A125	R:R:W119	3.89	No	Yes	0	6	8
188	R:R:S179	R:R:Y180	3.82	No	Yes	0	7	3
189	R:R:F225	R:R:M221	3.73	No	Yes	0	4	4
190	R:R:F222	R:R:L182	3.65	No	No	0	4	4
191	R:R:F225	R:R:L229	3.65	No	No	0	4	5
192	R:R:I78	R:R:Y82	3.63	No	Yes	0	7	6
193	R:R:K81	R:R:Y82	3.58	No	Yes	0	5	6
194	R:R:P293	R:R:T292	3.5	No	No	0	9	6
195	R:R:C238	R:R:S148	3.44	No	No	0	7	9
196	L:L:S4	R:R:A205	3.42	No	No	0	0	1
197	L:L:G6	R:R:L308	3.42	No	No	0	0	1
198	R:R:A52	R:R:S316	3.42	No	No	0	2	3
199	R:R:A98	R:R:S139	3.42	No	No	0	8	7
200	R:R:G337	R:R:L338	3.42	No	No	0	7	7
201	R:R:I184	R:R:P185	3.39	No	No	0	4	7
202	R:R:I269	R:R:P270	3.39	Yes	No	0	4	3
203	R:R:M107	R:R:P108	3.35	No	No	0	7	8
204	R:R:L159	R:R:P158	3.28	No	No	0	6	7
205	R:R:V236	R:R:V284	3.21	No	No	0	4	8
206	R:R:C330	R:R:L63	3.17	No	No	0	7	7
207	R:R:C238	R:R:L149	3.17	No	No	0	7	6
208	R:R:M171	R:R:V146	3.04	No	No	0	5	6
209	R:R:M235	R:R:V284	3.04	No	No	0	8	8
210	L:L:L7	R:R:V193	2.98	No	No	0	0	1
211	R:R:L172	R:R:V146	2.98	No	No	0	7	6
212	R:R:L285	R:R:V284	2.98	No	No	0	5	8
213	R:R:L323	R:R:T60	2.95	No	No	0	5	6
214	R:R:I55	R:R:I59	2.94	No	No	0	5	5
215	R:R:A52	R:R:H319	2.93	No	Yes	0	2	4
216	R:R:I90	R:R:K165	2.91	No	No	0	6	2
217	R:R:F70	R:R:P333	2.89	No	Yes	0	8	9
218	R:R:F287	R:R:P231	2.89	No	No	0	9	9
219	R:R:I93	R:R:L75	2.85	No	No	0	6	7
220	R:R:E306	R:R:T309	2.82	No	No	0	1	4
221	R:R:E310	R:R:T309	2.82	No	No	0	1	4
222	R:R:R241	R:R:S237	2.64	Yes	No	0	4	4
223	R:R:R273	R:R:S247	2.64	No	No	0	7	4
224	R:R:F188	R:R:I184	2.51	No	No	0	4	4
225	R:R:F64	R:R:L104	2.44	No	No	0	6	5
226	R:R:L124	R:R:R127	2.43	No	Yes	0	2	7
227	R:R:L187	R:R:R127	2.43	No	Yes	0	5	7
228	R:R:F66	R:R:F70	2.14	No	No	0	6	8
229	R:R:A121	R:R:G122	1.95	No	No	0	7	8
230	R:R:A74	R:R:P333	1.87	No	Yes	0	9	9
231	R:R:A141	R:R:P231	1.87	No	No	0	8	9
232	R:R:G208	R:R:S209	1.86	No	No	0	5	3
233	R:R:G208	R:R:V207	1.84	No	No	0	5	4
234	R:R:P305	R:R:S304	1.78	No	No	0	3	4
235	R:R:G162	R:R:I161	1.76	No	No	0	4	5
236	R:R:C330	R:R:S67	1.72	No	No	0	7	8
237	R:R:A111	R:R:V57	1.7	No	No	0	7	5
238	R:R:A175	R:R:V146	1.7	No	No	0	7	6
239	R:R:D163	R:R:G162	1.68	No	No	0	4	4
240	R:R:N157	R:R:P158	1.63	No	No	0	6	7
241	R:R:N268	R:R:P270	1.63	No	No	0	3	3
242	R:R:A58	R:R:I59	1.62	No	No	0	5	5
243	R:R:A154	R:R:I155	1.62	No	No	0	8	8
244	R:R:A154	R:R:I161	1.62	No	No	0	8	5
245	R:R:A272	R:R:I246	1.62	No	No	8	5	8
246	R:R:A272	R:R:I269	1.62	No	Yes	8	5	4
247	R:R:S50	R:R:T51	1.6	No	No	0	5	5
248	R:R:S280	R:R:T276	1.6	No	No	0	8	8
249	R:R:T116	R:R:V112	1.59	No	No	0	5	4
250	R:R:T286	R:R:V282	1.59	No	No	0	7	6
251	R:R:I288	R:R:V289	1.54	No	No	0	6	5
252	R:R:I55	R:R:T51	1.52	No	No	0	5	5
253	R:R:I246	R:R:T276	1.52	No	No	0	8	8
254	R:R:L124	R:R:V128	1.49	No	No	0	2	4
255	R:R:L129	R:R:V128	1.49	No	No	0	5	4
256	R:R:N328	R:R:S140	1.49	No	No	0	9	9
257	R:R:I334	R:R:I335	1.47	No	Yes	0	6	8
258	R:R:I170	R:R:M171	1.46	No	No	0	3	5
259	R:R:K83	R:R:K84	1.44	No	No	0	6	7
260	R:R:K165	R:R:K85	1.44	No	No	0	2	7
261	R:R:K166	R:R:K167	1.44	No	No	0	4	4
262	R:R:K312	R:R:M307	1.44	No	Yes	0	3	3
263	R:R:I72	R:R:L100	1.43	No	No	0	4	7
264	R:R:K81	R:R:L338	1.41	No	No	0	5	7
265	R:R:L338	R:R:M279	1.41	No	No	0	7	8
266	R:R:L178	R:R:L181	1.38	No	No	0	3	4
267	R:R:A272	R:R:R275	1.38	No	No	0	5	7
268	R:R:L296	R:R:L297	1.38	No	No	0	6	4
269	R:R:L156	R:R:N157	1.37	No	No	0	7	6
270	R:R:H319	R:R:I320	1.33	Yes	No	0	4	5
271	R:R:A97	R:R:W176	1.3	No	Yes	0	6	9
272	R:R:R241	R:R:T240	1.29	Yes	No	0	4	4
273	R:R:F66	R:R:I65	1.26	No	No	0	6	6
274	R:R:Q118	R:R:R195	1.17	No	No	0	4	2
275	R:R:I218	R:R:W214	1.17	No	No	0	4	1
276	L:L:R8	R:R:E311	1.16	No	No	0	0	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	14.7817	6	1	0
2	L:L:H2	8.226	5	1	0
3	L:L:W3	15.136	5	1	0
4	L:L:Y5	9.68	5	0	0
5	R:R:R56	10.088	5	1	4
6	R:R:N71	8.6325	4	4	9
7	R:R:Y82	5.19	4	0	6
8	R:R:H87	6.636	5	0	7
9	R:R:L91	5.525	4	6	7
10	R:R:F101	6.225	4	0	6
11	R:R:W113	15.7975	4	3	5
12	R:R:W119	10.628	5	0	8
13	R:R:R127	6.7475	4	0	7
14	R:R:Y138	7.2775	4	7	6
15	R:R:W176	4.4875	4	0	9
16	R:R:Y180	4.785	4	0	3
17	R:R:F190	7.904	5	2	5
18	R:R:T206	6.5775	4	2	4
19	R:R:F210	8.075	4	2	4
20	R:R:M221	5.784	5	1	4
21	R:R:Y239	7.4425	4	0	9
22	R:R:R241	6.0175	4	0	4
23	R:R:I269	4.345	4	8	4
24	R:R:Y294	11.996	5	1	6
25	R:R:Y295	6.92833	6	1	7
26	R:R:W302	13.4225	4	1	4
27	R:R:M307	7.4675	4	0	3
28	R:R:H319	5.074	5	1	4
29	R:R:F322	9.176	5	1	5
30	R:R:P333	4.435	4	4	9
31	R:R:I335	4.0875	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	43.4509	5.5	Yes	Yes	1	0	0
2	L:L:H2	R:R:M137	14.6649	6.57	Yes	No	0	0	7
3	L:L:H2	R:R:Y295	34.3444	6.53	Yes	Yes	1	0	7
4	L:L:?1	R:R:Y294	31.018	17.56	Yes	Yes	1	0	6
5	R:R:Y294	R:R:Y295	72.8736	6.95	Yes	Yes	1	6	7
6	L:L:W3	R:R:W302	10.6946	16.87	Yes	Yes	1	0	4
7	R:R:L227	R:R:M137	13.8422	5.65	No	No	0	5	7
8	R:R:L227	R:R:Y138	82.1804	9.38	No	Yes	0	5	6
9	R:R:L134	R:R:Y138	61.4922	8.21	No	Yes	7	4	6
10	R:R:L134	R:R:Q186	59.4463	11.98	No	No	0	4	4
11	R:R:F190	R:R:Q186	49.7604	7.03	Yes	No	0	5	4
12	R:R:F190	R:R:T206	26.3252	7.78	Yes	Yes	2	5	4
13	R:R:L227	R:R:Y295	71.9007	7.03	No	Yes	0	5	7
14	L:L:?1	R:R:F322	30.8963	20.85	Yes	Yes	1	0	5
15	L:L:Y5	R:R:F322	32.8135	5.16	Yes	Yes	0	0	5
16	L:L:Y5	R:R:M307	12.855	8.38	Yes	Yes	0	0	3
17	R:R:F190	R:R:M130	10.5873	14.93	Yes	No	0	5	5
18	R:R:F322	R:R:R56	27.6701	5.34	Yes	Yes	1	5	4
19	R:R:L323	R:R:R56	13.4559	14.58	No	Yes	0	5	4
20	L:L:?1	R:R:K133	100	4.53	Yes	No	1	0	6
21	R:R:K133	R:R:V106	99.7139	4.55	No	No	0	6	7
22	R:R:I102	R:R:V106	84.9059	7.68	No	No	0	7	7
23	R:R:I102	R:R:T329	30.553	6.08	No	No	0	7	8
24	R:R:D99	R:R:T329	28.085	10.12	No	No	0	9	8
25	R:R:D99	R:R:P333	15.3588	4.83	No	Yes	4	9	9
26	R:R:F70	R:R:P333	10.4085	2.89	No	Yes	0	8	9
27	R:R:L326	R:R:V106	24.7156	4.47	No	No	0	7	7
28	R:R:L326	R:R:M107	22.0259	9.9	No	No	0	7	7
29	R:R:F64	R:R:M107	16.6035	4.98	No	No	0	6	7
30	R:R:F64	R:R:T103	11.1238	5.19	No	No	0	6	6
31	R:R:D99	R:R:N71	10.2368	12.12	No	Yes	4	9	9
32	R:R:F228	R:R:Y295	86.6299	5.16	No	Yes	1	8	7
33	R:R:F228	R:R:F287	91.2941	6.43	No	No	0	8	9
34	R:R:F287	R:R:M235	86.3366	6.22	No	No	0	9	8
35	R:R:M235	R:R:S148	83.4609	6.13	No	No	0	8	9
36	R:R:S148	R:R:Y239	73.5103	6.36	No	Yes	0	9	9
37	R:R:R151	R:R:Y239	30.739	7.2	No	Yes	0	9	9
38	R:R:M279	R:R:R151	29.4871	6.2	No	No	0	8	9
39	R:R:L338	R:R:M279	56.7923	1.41	No	No	0	7	8
40	R:R:K81	R:R:L338	52.3714	1.41	No	No	0	5	7
41	R:R:K81	R:R:Y82	50.4543	3.58	No	Yes	0	5	6
42	R:R:I78	R:R:Y82	16.9468	3.63	No	Yes	0	7	6
43	R:R:I78	R:R:R89	11.4457	6.26	No	No	0	7	8
44	R:R:I283	R:R:Y239	30.925	6.04	No	Yes	0	8	9
45	R:R:I283	R:R:M279	29.7303	5.83	No	No	0	8	8
46	R:R:I88	R:R:Y82	38.2288	8.46	No	Yes	0	8	6
47	R:R:A136	R:R:I102	67.5156	4.87	No	No	0	8	7
48	R:R:A136	R:R:F101	66.3066	8.32	No	Yes	0	8	6
49	R:R:F101	R:R:Y180	61.528	5.16	Yes	Yes	0	6	3
50	R:R:W176	R:R:Y180	57.4934	4.82	Yes	Yes	0	9	3
51	R:R:N94	R:R:W176	53.4516	5.65	No	Yes	0	9	9
52	R:R:L172	R:R:N94	51.2268	13.73	No	No	0	7	9
53	R:R:L172	R:R:L91	45.9046	4.15	No	Yes	0	7	7
54	R:R:D150	R:R:L91	34.4302	5.43	No	Yes	6	8	7
55	R:R:D150	R:R:H87	34.7307	6.3	No	Yes	0	8	7
56	R:R:H87	R:R:I88	37.0914	13.26	Yes	No	0	7	8
57	R:R:H87	R:R:I161	14.4431	5.3	Yes	No	0	7	5
58	R:R:I147	R:R:L91	26.783	4.28	No	Yes	0	9	7
59	R:R:I147	R:R:L95	24.7371	5.71	No	No	0	9	9
60	R:R:F101	R:R:L132	33.1211	4.87	Yes	No	0	6	5
61	R:R:C126	R:R:F190	21.2533	4.19	No	Yes	2	9	5
62	R:R:C126	R:R:W119	20.5666	10.45	No	Yes	0	9	8
63	R:R:L129	R:R:W119	20.7168	4.56	No	Yes	0	5	8
64	R:R:F131	R:R:L132	31.4901	6.09	No	No	0	6	5
65	R:R:F131	R:R:L187	28.3997	8.53	No	No	0	6	5
66	R:R:L187	R:R:R127	27.0119	2.43	No	Yes	0	5	7
67	R:R:C226	R:R:Y138	20.4736	4.03	No	Yes	0	4	6
68	R:R:C226	R:R:F222	17.5907	8.38	No	No	0	4	4
69	R:R:F222	R:R:L182	14.6935	3.65	No	No	0	4	4
70	R:R:L178	R:R:L182	11.782	5.54	No	No	0	3	4
71	R:R:L95	R:R:Y336	20.2804	4.69	No	No	0	9	9
72	R:R:F287	R:R:P231	13.0124	2.89	No	No	0	9	9
73	R:R:C238	R:R:S148	30.1238	3.44	No	No	0	7	9
74	R:R:C238	R:R:Q152	25.245	13.74	No	No	0	7	8
75	R:R:Q152	R:R:R241	22.777	12.85	No	Yes	0	8	4
76	R:R:L156	R:R:R241	15.3015	7.29	No	Yes	0	7	4
77	R:R:L172	R:R:V146	14.3716	2.98	No	No	0	7	6
78	R:R:Q186	R:R:Y219	12.0753	5.64	No	No	0	4	5
79	R:R:F210	R:R:T206	17.1185	6.49	Yes	Yes	2	4	4
80	R:R:F210	R:R:Q215	12.3328	4.68	Yes	No	0	4	3
81	R:R:F322	R:R:L297	20.0801	7.31	Yes	No	0	5	4
82	R:R:L297	R:R:L321	16.4461	6.92	No	No	0	4	6
83	R:R:L321	R:R:P293	11.4529	6.57	No	No	0	6	9
84	R:R:S280	R:R:Y239	31.7119	10.17	No	Yes	0	8	9
85	R:R:S280	R:R:T276	29.4656	1.6	No	No	0	8	8
86	R:R:I246	R:R:T276	19.8584	1.52	No	No	0	8	8
87	R:R:I246	R:R:I269	12.6475	7.36	No	Yes	8	8	4
88	R:R:I335	R:R:Y336	15.974	6.04	Yes	No	0	8	9
89	R:R:W291	R:R:Y295	12.6905	8.68	No	Yes	0	8	7
90	R:R:L124	R:R:R127	19.4506	2.43	No	Yes	0	2	7
91	R:R:L129	R:R:V128	19.6223	1.49	No	No	0	5	4
92	R:R:L124	R:R:V128	19.1144	1.49	No	No	0	2	4
93	R:R:F322	R:R:Y294	42.9931	7.22	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K133	4.53	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y294	17.56	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F322	20.85	1	Yes	Yes	0	5	0	1
L:L:H2	R:R:M137	6.57	1	Yes	No	0	7	0	1
L:L:H2	R:R:Y294	10.89	1	Yes	Yes	0	6	0	1
L:L:H2	R:R:Y295	6.53	1	Yes	Yes	0	7	0	1
L:L:W3	R:R:Y294	17.36	1	Yes	Yes	0	6	0	1
L:L:W3	R:R:G298	4.22	1	Yes	No	0	5	0	1
L:L:W3	R:R:W302	16.87	1	Yes	Yes	0	4	0	1
L:L:S4	R:R:T206	6.4	0	No	Yes	0	4	0	1
L:L:Y5	R:R:Y301	10.92	0	Yes	No	0	3	0	1
L:L:Y5	R:R:M307	8.38	0	Yes	Yes	0	3	0	1
L:L:Y5	R:R:L308	17.58	0	Yes	No	0	1	0	1
L:L:Y5	R:R:S318	6.36	0	Yes	No	0	4	0	1
L:L:Y5	R:R:F322	5.16	0	Yes	Yes	0	5	0	1
L:L:L7	R:R:Q203	10.65	0	No	No	0	4	0	1
L:L:R8	R:R:L308	6.07	0	No	No	0	1	0	1
L:L:R8	R:R:P315	5.76	0	No	No	0	4	0	1
L:L:P9	R:R:W113	5.4	3	No	Yes	0	5	0	1
L:L:P9	R:R:L117	11.49	3	No	No	0	5	0	1
L:L:P9	R:R:Q203	9.47	3	No	No	0	4	0	1
L:L:?11	R:R:K133	6.98	1	No	No	0	6	0	1
R:R:F322	R:R:R56	5.34	1	Yes	Yes	5	4	1	2
R:R:K133	R:R:V106	4.55	1	No	No	6	7	1	2
R:R:W113	R:R:W119	29.05	3	Yes	Yes	5	8	1	2
R:R:M130	R:R:W113	4.65	0	No	Yes	5	5	2	1
R:R:Q203	R:R:W113	24.09	3	No	Yes	4	5	1	1
R:R:F190	R:R:M130	14.93	2	Yes	No	5	5	2	2
R:R:L227	R:R:M137	5.65	0	No	No	5	7	2	1
R:R:F190	R:R:T206	7.78	2	Yes	Yes	5	4	2	1
R:R:F210	R:R:T206	6.49	2	Yes	Yes	4	4	2	1
R:R:E216	R:R:T206	5.64	2	No	Yes	4	4	2	1
R:R:E216	R:R:F210	9.33	2	No	Yes	4	4	2	2
R:R:N220	R:R:W302	23.73	0	No	Yes	4	4	2	1
R:R:F224	R:R:M221	7.46	1	No	Yes	5	4	2	2
R:R:M221	R:R:W302	4.65	1	Yes	Yes	4	4	2	1
R:R:F224	R:R:F228	8.57	1	No	No	5	8	2	2
R:R:F224	R:R:Y295	7.22	1	No	Yes	5	7	2	1
R:R:L227	R:R:Y295	7.03	0	No	Yes	5	7	2	1
R:R:F228	R:R:Y295	5.16	1	No	Yes	8	7	2	1
R:R:W291	R:R:Y295	8.68	0	No	Yes	8	7	2	1
R:R:Y294	R:R:Y295	6.95	1	Yes	Yes	6	7	1	1
R:R:F322	R:R:Y294	7.22	1	Yes	Yes	5	6	1	1
R:R:F322	R:R:L297	7.31	1	Yes	No	5	4	1	2
R:R:G298	R:R:W302	8.44	1	No	Yes	5	4	1	1
R:R:M307	R:R:W300	13.96	0	Yes	No	3	4	1	2
R:R:P305	R:R:Y301	5.56	0	No	No	3	3	2	1
R:R:M307	R:R:V313	6.09	0	Yes	No	3	5	1	2
L:L:S4	R:R:A205	3.42	0	No	No	0	1	0	1
L:L:G6	R:R:L308	3.42	0	No	No	0	1	0	1
L:L:L7	R:R:V193	2.98	0	No	No	0	1	0	1
R:R:K312	R:R:M307	1.44	0	No	Yes	3	3	2	1
L:L:R8	R:R:E311	1.16	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9U4Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.14
Number of Linked Nodes	256
Number of Links	276
Number of Hubs	31
Number of Links mediated by Hubs	117
Number of Communities	8
Number of Nodes involved in Communities	42
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	41849
Length Of Smallest Path	3
Average Path Length	13.9018
Length of Longest Path	28
Minimum Path Strength	1.41
Average Path Strength	6.66838
Maximum Path Strength	26.57
Minimum Path Correlation	0.7
Average Path Correlation	0.9172
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	41.8504
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.8415
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	L-pyroglutamic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?11
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q90WJ2
Sequence	>9U4Y_nogp_Chain_R S T A A K I R V A I T C V L F I F S A C F N I A A L W T I T Y K Y K K K S H I R I L I I N L V A A D L F I T L V V M P L D A V W N V T L Q W Y A G D L A C R V L M F L K L A A M Y S S A F V T V V I S L D R Q A A I L N P L G I G D A K K K N K I M L C V A W F L S Y L L A I P Q L F V F H T V S R Q C A T V G S F Q A H W Q E T I Y N M F T F F C L F L L P L L I M V S C Y T R I L M E I S H K N I P R A R M R T L K M S L V I V L T F I V C W T P Y Y L L G I W Y W F S P E M L T E E K V P P S L S H I L F L F G L L N T C L D P I I Y G L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7BR3	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Homo sapiens	Elagolix	-	-	2.79	2020-10-07	doi.org/10.1038/s41467-020-19109-w
	9U4W	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Sus scrofa	Gonadoliberin-1	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.18	2025-06-11	doi.org/10.1073/pnas.2500112122
	9U4W (No Gprot)	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Sus scrofa	Gonadoliberin-1	-		3.18	2025-06-11	doi.org/10.1073/pnas.2500112122
	9U4Y	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Xenopus laevis	Gonadoliberin-1	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.18	2025-06-11	doi.org/10.1073/pnas.2500112122
	9U4Y (No Gprot)	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Xenopus laevis	Gonadoliberin-1	-		3.18	2025-06-11	doi.org/10.1073/pnas.2500112122

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