psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	5.5	Yes	Yes	1	0	0
2	L:L:?1	L:L:W3	13.4	Yes	Yes	1	0	0
3	L:L:?1	L:L:G10	5.49	Yes	No	1	0	0
4	L:L:?1	L:L:?11	21.99	Yes	No	1	0	0
5	L:L:?1	R:R:D98	4.36	Yes	Yes	1	0	6
6	L:L:?1	R:R:K121	6.03	Yes	No	0	0	7
7	L:L:?1	R:R:Y283	17.56	Yes	Yes	1	0	6
8	L:L:?1	R:R:F309	15.64	Yes	Yes	1	0	5
9	L:L:H2	L:L:W3	9.52	Yes	Yes	1	0	0
10	L:L:H2	R:R:T215	9.58	Yes	No	1	0	5
11	L:L:H2	R:R:L219	3.86	Yes	Yes	1	0	4
12	L:L:H2	R:R:Y283	7.62	Yes	Yes	1	0	6
13	L:L:H2	R:R:Y284	7.62	Yes	Yes	1	0	7
14	L:L:W3	R:R:Y283	9.65	Yes	Yes	1	0	6
15	L:L:W3	R:R:G287	8.44	Yes	No	0	0	5
16	L:L:W3	R:R:W291	14.99	Yes	Yes	0	0	4
17	L:L:W3	R:R:F309	4.01	Yes	Yes	1	0	5
18	L:L:S4	R:R:V197	6.46	No	No	0	0	5
19	L:L:Y5	R:R:Y290	5.96	Yes	Yes	0	0	4
20	L:L:Y5	R:R:V297	5.05	Yes	No	0	0	1
21	L:L:Y5	R:R:N305	12.79	Yes	No	0	0	3
22	L:L:Y5	R:R:F309	8.25	Yes	Yes	0	0	5
23	L:L:L7	R:R:F193	3.65	No	No	0	0	4
24	L:L:R8	R:R:P29	8.65	No	No	0	0	6
25	L:L:R8	R:R:N305	9.64	No	No	0	0	3
26	L:L:R8	R:R:H306	4.51	No	Yes	0	0	5
27	L:L:P9	R:R:N102	11.4	No	Yes	0	0	5
28	L:L:?11	L:L:G10	4.23	No	No	1	0	0
29	L:L:?11	R:R:D98	10.08	No	Yes	1	0	6
30	R:R:L28	R:R:P29	4.93	No	No	0	4	6
31	R:R:F193	R:R:L28	18.27	No	No	0	4	4
32	R:R:L31	R:R:V105	4.47	No	No	0	6	4
33	R:R:K36	R:R:L33	4.23	No	No	0	5	4
34	R:R:P303	R:R:S34	7.13	No	No	1	2	4
35	R:R:H306	R:R:S34	6.97	Yes	No	1	5	4
36	R:R:F307	R:R:S34	6.61	Yes	No	1	5	4
37	R:R:G35	R:R:H306	6.35	No	Yes	0	5	5
38	R:R:F307	R:R:I37	5.02	Yes	No	0	5	5
39	R:R:D98	R:R:R38	5.96	Yes	Yes	1	6	5
40	R:R:N102	R:R:R38	18.08	Yes	Yes	1	5	5
41	R:R:H306	R:R:R38	11.28	Yes	Yes	1	5	5
42	R:R:L310	R:R:R38	4.86	No	Yes	0	5	5
43	R:R:I103	R:R:V39	10.75	No	Yes	0	4	6
44	R:R:L310	R:R:V41	4.47	No	No	0	5	5
45	R:R:F44	R:R:L48	13.4	No	No	0	5	5
46	R:R:F46	R:R:T50	3.89	Yes	No	0	7	6
47	R:R:F46	R:R:L92	3.65	Yes	No	0	7	4
48	R:R:F46	R:R:M95	4.98	Yes	No	0	7	7
49	R:R:F46	R:R:P96	8.67	Yes	No	0	7	9
50	R:R:S49	R:R:T91	7.99	No	No	0	7	6
51	R:R:F52	R:R:L321	8.53	No	No	0	6	6
52	R:R:N53	R:R:T84	4.39	Yes	No	0	9	9
53	R:R:N53	R:R:N87	4.09	Yes	Yes	0	9	9
54	R:R:L88	R:R:N53	5.49	No	Yes	0	8	9
55	R:R:N53	R:R:P320	11.4	Yes	No	0	9	9
56	R:R:F56	R:R:L60	8.53	Yes	No	0	7	5
57	R:R:F56	R:R:T84	7.78	Yes	No	0	7	9
58	R:R:F56	R:R:G324	4.52	Yes	No	0	7	7
59	R:R:L57	R:R:T84	8.84	No	No	0	8	9
60	R:R:L57	R:R:L85	5.54	No	No	0	8	5
61	R:R:K62	R:R:L58	4.23	No	No	0	6	4
62	R:R:L60	R:R:L80	4.15	No	No	0	5	8
63	R:R:K77	R:R:S74	4.59	No	No	0	7	7
64	R:R:D138	R:R:R75	8.34	No	No	0	9	6
65	R:R:G156	R:R:R75	7.51	No	No	0	7	6
66	R:R:H82	R:R:I160	9.28	No	No	0	9	7
67	R:R:L83	R:R:N87	4.12	No	Yes	0	9	9
68	R:R:L83	R:R:M131	7.07	No	No	0	9	8
69	R:R:L83	R:R:Y323	4.69	No	Yes	0	9	9
70	R:R:D319	R:R:N87	10.77	No	Yes	0	9	9
71	R:R:F123	R:R:L89	4.87	Yes	No	0	5	7
72	R:R:E90	R:R:V94	4.28	Yes	No	3	6	6
73	R:R:E90	R:R:S124	10.06	Yes	No	3	6	8
74	R:R:E90	R:R:M125	4.06	Yes	No	0	6	7
75	R:R:E90	R:R:P316	4.72	Yes	No	0	6	9
76	R:R:P316	R:R:T91	3.5	No	No	0	9	6
77	R:R:I93	R:R:L120	5.71	No	No	0	5	6
78	R:R:K121	R:R:V94	7.59	No	No	0	7	6
79	R:R:S124	R:R:V94	4.85	No	No	3	8	6
80	R:R:F313	R:R:M95	8.71	No	No	0	7	7
81	R:R:L97	R:R:W101	10.25	No	Yes	0	5	5
82	R:R:L117	R:R:L97	5.54	No	No	0	5	5
83	R:R:D98	R:R:F313	8.36	Yes	No	0	6	7
84	R:R:M100	R:R:W107	5.82	No	Yes	0	4	9
85	R:R:W101	R:R:W107	39.36	Yes	Yes	2	5	9
86	R:R:Q195	R:R:W101	7.67	No	Yes	0	4	5
87	R:R:C196	R:R:W101	5.22	Yes	Yes	2	9	5
88	R:R:H306	R:R:N102	6.38	Yes	Yes	1	5	5
89	R:R:Q106	R:R:V105	4.3	No	No	0	5	4
90	R:R:F193	R:R:Q106	16.4	No	No	0	4	5
91	R:R:Q106	R:R:S194	7.22	No	No	0	5	4
92	R:R:A109	R:R:W107	3.89	No	Yes	0	6	9
93	R:R:C114	R:R:W107	5.22	No	Yes	2	9	9
94	R:R:C196	R:R:W107	5.22	Yes	Yes	2	9	9
95	R:R:S194	R:R:Y108	3.82	No	No	0	4	4
96	R:R:E111	R:R:K115	9.45	No	No	0	4	8
97	R:R:E111	R:R:R179	8.14	No	No	0	4	5
98	R:R:E111	R:R:M180	5.41	No	No	0	4	5
99	R:R:F112	R:R:V116	3.93	No	No	0	2	4
100	R:R:C114	R:R:C196	7.28	No	Yes	2	9	9
101	R:R:Q174	R:R:S118	4.33	Yes	No	2	4	5
102	R:R:F178	R:R:S118	13.21	Yes	No	2	5	5
103	R:R:F123	R:R:Y119	7.22	Yes	No	0	5	6
104	R:R:A171	R:R:Y119	4	No	No	0	6	6
105	R:R:L175	R:R:Y119	5.86	No	No	0	5	6
106	R:R:K121	R:R:M125	4.32	No	No	0	7	7
107	R:R:L122	R:R:Y126	17.58	No	No	0	5	6
108	R:R:L122	R:R:Q174	7.99	No	Yes	0	5	4
109	R:R:F123	R:R:W164	7.02	Yes	No	0	5	9
110	R:R:F123	R:R:S167	7.93	Yes	No	0	5	8
111	R:R:F123	R:R:S168	6.61	Yes	No	0	5	4
112	R:R:T215	R:R:Y126	4.99	No	No	1	5	6
113	R:R:L219	R:R:Y126	7.03	Yes	No	1	4	6
114	R:R:A127	R:R:W164	3.89	No	No	0	7	9
115	R:R:A129	R:R:P223	3.74	No	No	0	7	9
116	R:R:F130	R:R:L166	3.65	No	No	0	6	4
117	R:R:C218	R:R:F130	4.19	No	No	0	4	6
118	R:R:M132	R:R:M227	7.22	No	No	0	8	8
119	R:R:P223	R:R:V133	3.53	No	No	0	9	6
120	R:R:I226	R:R:V133	4.61	No	No	0	6	6
121	R:R:I135	R:R:Y323	3.63	No	Yes	0	9	9
122	R:R:M227	R:R:S136	7.67	No	No	0	8	9
123	R:R:N231	R:R:R139	4.82	No	No	0	9	9
124	R:R:M268	R:R:R139	11.17	No	No	0	8	9
125	R:R:C230	R:R:S140	6.89	No	No	0	5	7
126	R:R:L141	R:R:V149	8.94	No	No	0	4	6
127	R:R:I143	R:R:I234	5.89	No	Yes	0	8	8
128	R:R:R145	R:R:T144	3.88	Yes	Yes	0	5	7
129	R:R:T144	R:R:T237	4.71	Yes	No	0	7	5
130	R:R:R145	R:R:V149	6.54	Yes	No	0	5	6
131	R:R:N152	R:R:S151	5.96	No	No	0	5	5
132	R:R:F158	R:R:R154	10.69	No	No	0	4	4
133	R:R:F158	R:R:L162	8.53	No	No	0	4	3
134	R:R:F170	R:R:L166	3.65	No	No	0	5	4
135	R:R:F170	R:R:I169	6.28	No	No	0	5	4
136	R:R:F170	R:R:F214	6.43	No	No	0	5	3
137	R:R:G172	R:R:P173	4.06	No	No	0	4	8
138	R:R:P173	R:R:Y211	4.17	No	No	0	8	5
139	R:R:F178	R:R:Q174	14.05	Yes	Yes	2	5	4
140	R:R:Q174	R:R:Y211	6.76	Yes	No	0	4	5
141	R:R:I177	R:R:Y176	4.84	Yes	No	5	4	5
142	R:R:S201	R:R:Y176	3.82	No	No	5	3	5
143	R:R:I177	R:R:T198	4.56	Yes	No	0	4	8
144	R:R:I177	R:R:S201	10.84	Yes	No	5	4	3
145	R:R:F202	R:R:I177	10.05	Yes	Yes	0	5	4
146	R:R:F178	R:R:T198	5.19	Yes	No	0	5	8
147	R:R:I181	R:R:R179	8.77	No	No	0	2	5
148	R:R:R179	R:R:S201	5.27	No	No	0	5	3
149	R:R:I181	R:R:V197	4.61	No	No	0	2	5
150	R:R:H182	R:R:L183	7.71	No	No	0	3	1
151	R:R:G192	R:R:H182	6.35	No	No	0	4	3
152	R:R:H199	R:R:V197	15.22	No	No	0	4	5
153	R:R:F202	R:R:H207	4.53	Yes	No	0	5	3
154	R:R:F202	R:R:Q208	5.86	Yes	No	0	5	4
155	R:R:F202	R:R:Y211	6.19	Yes	No	0	5	5
156	R:R:H207	R:R:P203	10.68	No	No	0	3	4
157	R:R:Q204	R:R:W206	7.67	No	No	0	3	2
158	R:R:H207	R:R:Q204	8.65	No	No	0	3	3
159	R:R:W205	R:R:W206	22.49	No	No	0	2	2
160	R:R:N212	R:R:W291	27.12	No	Yes	0	5	4
161	R:R:F213	R:R:S217	7.93	No	No	0	4	4
162	R:R:L219	R:R:T215	4.42	Yes	No	1	4	5
163	R:R:F216	R:R:F220	10.72	No	No	0	5	8
164	R:R:F216	R:R:Y284	19.6	No	Yes	0	5	7
165	R:R:L219	R:R:Y284	4.69	Yes	Yes	1	4	7
166	R:R:F220	R:R:F276	7.5	No	No	0	8	9
167	R:R:F276	R:R:L224	6.09	No	No	0	9	6
168	R:R:F272	R:R:M227	4.98	Yes	No	0	8	8
169	R:R:N231	R:R:T269	14.62	No	No	0	9	8
170	R:R:I234	R:R:T265	6.08	Yes	No	0	8	8
171	R:R:M235	R:R:T265	6.02	No	No	0	5	8
172	R:R:L266	R:R:M235	4.24	No	No	0	7	5
173	R:R:F236	R:R:R240	16.03	No	No	0	4	4
174	R:R:I258	R:R:L238	4.28	Yes	No	0	4	8
175	R:R:R262	R:R:T239	14.23	No	No	0	8	4
176	R:R:I258	R:R:L242	8.56	Yes	No	0	4	4
177	R:R:F272	R:R:M268	4.98	Yes	No	0	8	8
178	R:R:F326	R:R:M268	12.44	Yes	No	0	8	8
179	R:R:F272	R:R:I322	6.28	Yes	No	0	8	8
180	R:R:F272	R:R:Y323	16.5	Yes	Yes	0	8	9
181	R:R:F318	R:R:S275	5.28	No	No	0	6	6
182	R:R:C279	R:R:W280	3.92	No	No	0	8	8
183	R:R:C279	R:R:F318	4.19	No	No	0	8	6
184	R:R:W280	R:R:Y284	8.68	No	Yes	0	8	7
185	R:R:N315	R:R:W280	9.04	No	No	0	9	8
186	R:R:P282	R:R:T281	3.5	No	No	0	9	5
187	R:R:F308	R:R:P282	4.33	No	No	0	6	9
188	R:R:F311	R:R:P282	5.78	No	No	0	7	9
189	R:R:Y283	R:R:Y284	6.95	Yes	Yes	1	6	7
190	R:R:F309	R:R:Y283	4.13	Yes	Yes	1	5	6
191	R:R:A312	R:R:Y283	5.34	No	Yes	0	7	6
192	R:R:W291	R:R:Y284	4.82	Yes	Yes	0	4	7
193	R:R:F308	R:R:L286	14.61	No	No	0	6	4
194	R:R:F309	R:R:L286	10.96	Yes	No	0	5	4
195	R:R:F292	R:R:I288	10.05	No	No	0	5	5
196	R:R:M296	R:R:W289	8.14	No	No	0	3	5
197	R:R:M296	R:R:Y290	7.18	No	Yes	0	3	4
198	R:R:E295	R:R:N298	10.52	No	No	0	3	4
199	R:R:S301	R:R:V304	9.7	No	No	0	4	4
200	R:R:N305	R:R:S301	5.96	No	No	0	3	4
201	R:R:F307	R:R:P303	4.33	Yes	No	1	5	2
202	R:R:F308	R:R:V304	6.55	No	No	0	6	4
203	R:R:F307	R:R:H306	4.53	Yes	Yes	1	5	5
204	R:R:F307	R:R:L310	4.87	Yes	No	0	5	5
205	R:R:F311	R:R:L314	3.65	No	No	0	7	5
206	R:R:F318	R:R:L314	6.09	No	No	0	6	5
207	R:R:N315	R:R:P316	4.89	No	No	0	9	9
208	R:R:D319	R:R:N315	10.77	No	No	0	9	9
209	R:R:D319	R:R:Y323	4.6	No	Yes	0	9	9
210	R:R:F326	R:R:Y325	6.19	Yes	No	0	8	7
211	R:R:C230	R:R:S136	3.44	No	No	0	5	9
212	R:R:I222	R:R:P223	3.39	No	No	0	5	9
213	R:R:I258	R:R:P259	3.39	Yes	No	0	4	4
214	R:R:N87	R:R:P128	3.26	Yes	No	0	9	9
215	R:R:C230	R:R:L137	3.17	No	No	0	5	6
216	R:R:A171	R:R:L122	3.15	No	No	0	6	5
217	R:R:I234	R:R:S140	3.1	Yes	No	0	8	7
218	R:R:I221	R:R:S217	3.1	No	No	0	4	4
219	R:R:I258	R:R:V241	3.07	Yes	No	0	4	6
220	R:R:I37	R:R:T40	3.04	No	No	0	5	3
221	R:R:I103	R:R:T104	3.04	No	No	0	4	5
222	R:R:M159	R:R:V134	3.04	No	No	0	5	6
223	R:R:I277	R:R:T281	3.04	No	No	0	6	5
224	R:R:M95	R:R:T42	3.01	No	No	0	7	8
225	R:R:F210	R:R:W206	3.01	No	No	0	3	2
226	R:R:L80	R:R:S327	3	No	No	0	8	9
227	R:R:L45	R:R:V41	2.98	No	No	0	8	5
228	R:R:L79	R:R:V78	2.98	No	No	0	7	5
229	R:R:L79	R:R:V134	2.98	No	No	0	7	6
230	R:R:L137	R:R:V133	2.98	No	No	0	6	6
231	R:R:N102	R:R:V39	2.96	Yes	Yes	0	5	6
232	R:R:I221	R:R:I222	2.94	No	No	0	4	5
233	R:R:I160	R:R:M131	2.92	No	No	0	7	8
234	R:R:D302	R:R:T32	2.89	No	No	0	3	4
235	R:R:F52	R:R:P320	2.89	No	No	0	6	9
236	R:R:I93	R:R:L89	2.85	No	No	0	5	7
237	R:R:I229	R:R:L225	2.85	No	No	0	4	4
238	R:R:L80	R:R:M76	2.83	No	No	0	8	7
239	R:R:L137	R:R:M159	2.83	No	No	0	6	5
240	R:R:L155	R:R:M159	2.83	No	No	0	5	5
241	R:R:K77	R:R:L328	2.82	No	No	0	7	7
242	R:R:K81	R:R:L85	2.82	No	No	0	5	5
243	R:R:C196	R:R:F178	2.79	Yes	Yes	2	9	5
244	R:R:P294	R:R:Y290	2.78	No	Yes	0	3	4
245	R:R:L113	R:R:L117	2.77	No	No	4	6	5
246	R:R:A148	R:R:R145	2.77	No	Yes	0	5	5
247	R:R:A271	R:R:F326	2.77	No	Yes	0	6	8
248	R:R:H306	R:R:T32	2.74	Yes	No	0	5	4
249	R:R:N256	R:R:N257	2.72	No	No	0	3	4
250	R:R:K81	R:R:Q61	2.71	No	No	0	5	1
251	R:R:D138	R:R:L79	2.71	No	No	0	9	7
252	R:R:F130	R:R:S167	2.64	No	No	0	6	8
253	R:R:F43	R:R:V39	2.62	No	Yes	0	3	6
254	R:R:A86	R:R:W164	2.59	No	No	0	8	9
255	R:R:F56	R:R:K59	2.48	Yes	No	0	7	6
256	R:R:F326	R:R:K267	2.48	Yes	No	0	8	6
257	R:R:F158	R:R:L155	2.44	No	No	0	4	5
258	R:R:L242	R:R:R262	2.43	No	No	0	4	8
259	R:R:G99	R:R:V39	1.84	No	Yes	0	6	6
260	R:R:G161	R:R:I160	1.76	No	No	0	3	7
261	R:R:G110	R:R:M180	1.75	No	No	0	8	5
262	R:R:C317	R:R:S49	1.72	No	No	0	6	7
263	R:R:A163	R:R:V134	1.7	No	No	0	7	6
264	R:R:A273	R:R:I277	1.62	No	No	0	7	6
265	R:R:D293	R:R:P294	1.61	No	No	0	3	3
266	R:R:T237	R:R:V241	1.59	No	No	0	5	6
267	R:R:T281	R:R:V285	1.59	No	No	0	5	5
268	R:R:A273	R:R:L228	1.58	No	No	0	7	4
269	R:R:A261	R:R:L238	1.58	No	No	0	6	8
270	R:R:T30	R:R:T32	1.57	No	No	0	6	4
271	R:R:M76	R:R:S74	1.53	No	No	0	7	7
272	R:R:I234	R:R:T144	1.52	Yes	Yes	0	8	7
273	R:R:K233	R:R:T144	1.5	No	Yes	0	4	7
274	R:R:L113	R:R:V116	1.49	No	No	4	6	4
275	R:R:L117	R:R:V116	1.49	No	No	4	5	4
276	R:R:L266	R:R:V270	1.49	No	No	0	7	5
277	L:L:G6	R:R:Y290	1.45	No	Yes	0	0	4
278	R:R:I37	R:R:K36	1.45	No	No	0	5	5
279	R:R:I229	R:R:K233	1.45	No	No	0	4	4
280	R:R:P146	R:R:R145	1.44	No	Yes	0	9	5
281	R:R:A51	R:R:F52	1.39	No	No	0	5	6
282	R:R:L155	R:R:N152	1.37	No	No	0	5	5
283	R:R:R260	R:R:R264	1.07	No	No	0	5	8
284	R:R:F292	R:R:W291	1	No	Yes	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.2462	8	1	0
2	L:L:H2	7.28333	6	1	0
3	L:L:W3	10.0017	6	1	0
4	L:L:Y5	8.0125	4	0	0
5	R:R:R38	10.045	4	1	5
6	R:R:V39	4.5425	4	0	6
7	R:R:F46	5.2975	4	0	7
8	R:R:N53	6.3425	4	0	9
9	R:R:F56	5.8275	4	0	7
10	R:R:N87	5.56	4	0	9
11	R:R:E90	5.78	4	3	6
12	R:R:D98	7.19	4	1	6
13	R:R:W101	15.625	4	2	5
14	R:R:N102	9.705	4	1	5
15	R:R:W107	11.902	5	2	9
16	R:R:F123	6.73	5	0	5
17	R:R:T144	2.9025	4	0	7
18	R:R:R145	3.6575	4	0	5
19	R:R:Q174	8.2825	4	2	4
20	R:R:I177	7.5725	4	5	4
21	R:R:F178	8.81	4	2	5
22	R:R:C196	5.1275	4	2	9
23	R:R:F202	6.6575	4	0	5
24	R:R:L219	5	4	1	4
25	R:R:I234	4.1475	4	0	8
26	R:R:I258	4.825	4	0	4
27	R:R:F272	8.185	4	0	8
28	R:R:Y283	8.54167	6	1	6
29	R:R:Y284	8.72667	6	1	7
30	R:R:Y290	4.3425	4	0	4
31	R:R:W291	11.9825	4	0	4
32	R:R:H306	6.10857	7	1	5
33	R:R:F307	5.072	5	1	5
34	R:R:F309	8.598	5	1	5
35	R:R:Y323	7.355	4	0	9
36	R:R:F326	5.97	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	53.4417	5.5	Yes	Yes	1	0	0
2	L:L:H2	R:R:T215	34.5675	9.58	Yes	No	1	0	5
3	L:L:H2	R:R:L219	34.1023	3.86	Yes	Yes	1	0	4
4	L:L:H2	R:R:Y284	15.4576	7.62	Yes	Yes	1	0	7
5	L:L:?1	R:R:Y283	14.301	17.56	Yes	Yes	1	0	6
6	R:R:Y283	R:R:Y284	31.019	6.95	Yes	Yes	1	6	7
7	R:R:T215	R:R:Y126	33.92	4.99	No	No	1	5	6
8	R:R:L122	R:R:Y126	100	17.58	No	No	0	5	6
9	R:R:L122	R:R:Q174	75.6663	7.99	No	Yes	0	5	4
10	R:R:F178	R:R:Q174	38.9458	14.05	Yes	Yes	2	5	4
11	R:R:F178	R:R:T198	20.4363	5.19	Yes	No	0	5	8
12	R:R:I177	R:R:T198	18.9527	4.56	Yes	No	0	4	8
13	R:R:I177	R:R:S201	30.8933	10.84	Yes	No	5	4	3
14	R:R:R179	R:R:S201	27.8602	5.27	No	No	0	5	3
15	R:R:I181	R:R:R179	12.4434	8.77	No	No	0	2	5
16	R:R:L219	R:R:Y126	67.2932	7.03	Yes	No	1	4	6
17	R:R:Q174	R:R:Y211	34.9415	6.76	Yes	No	0	4	5
18	R:R:F202	R:R:Y211	30.5947	6.19	Yes	No	0	5	5
19	R:R:F202	R:R:I177	18.8019	10.05	Yes	Yes	0	5	4
20	L:L:?1	R:R:F309	16.0988	15.64	Yes	Yes	1	0	5
21	L:L:Y5	R:R:F309	40.6965	8.25	Yes	Yes	0	0	5
22	L:L:Y5	R:R:Y290	13.1789	5.96	Yes	Yes	0	0	4
23	L:L:Y5	R:R:N305	25.2703	12.79	Yes	No	0	0	3
24	L:L:?1	R:R:D98	52.1844	4.36	Yes	Yes	1	0	6
25	R:R:D98	R:R:R38	43.3147	5.96	Yes	Yes	1	6	5
26	R:R:H306	R:R:R38	21.9732	11.28	Yes	Yes	1	5	5
27	L:L:R8	R:R:P29	24.494	8.65	No	No	0	0	6
28	R:R:L28	R:R:P29	21.7972	4.93	No	No	0	4	6
29	R:R:F193	R:R:L28	19.0942	18.27	No	No	0	4	4
30	L:L:R8	R:R:N305	22.5735	9.64	No	No	0	0	3
31	R:R:F193	R:R:Q106	13.6692	16.4	No	No	0	4	5
32	R:R:F307	R:R:I37	10.633	5.02	Yes	No	0	5	5
33	R:R:L310	R:R:R38	11.7331	4.86	No	Yes	0	5	5
34	R:R:W280	R:R:Y284	66.0862	8.68	No	Yes	0	8	7
35	R:R:N315	R:R:W280	66.8437	9.04	No	No	0	9	8
36	R:R:D319	R:R:N315	67.6232	10.77	No	No	0	9	9
37	R:R:D319	R:R:N87	24.1105	10.77	No	Yes	0	9	9
38	R:R:N53	R:R:N87	23.5102	4.09	Yes	Yes	0	9	9
39	R:R:N53	R:R:T84	17.0606	4.39	Yes	No	0	9	9
40	R:R:F56	R:R:T84	11.5131	7.78	Yes	No	0	7	9
41	R:R:D319	R:R:Y323	52.373	4.6	No	Yes	0	9	9
42	R:R:F272	R:R:Y323	53.1808	16.5	Yes	Yes	0	8	9
43	R:R:F272	R:R:M227	46.2692	4.98	Yes	No	0	8	8
44	R:R:M227	R:R:S136	44.8642	7.67	No	No	0	8	9
45	R:R:C230	R:R:S136	44.1162	3.44	No	No	0	5	9
46	R:R:C230	R:R:L137	22.5578	3.17	No	No	0	5	6
47	R:R:L137	R:R:M159	14.0684	2.83	No	No	0	6	5
48	R:R:A171	R:R:L122	28.8377	3.15	No	No	0	6	5
49	R:R:A171	R:R:Y119	27.2882	4	No	No	0	6	6
50	R:R:F123	R:R:Y119	24.1702	7.22	Yes	No	0	5	6
51	R:R:C196	R:R:F178	18.7233	2.79	Yes	Yes	2	9	5
52	R:R:C196	R:R:W101	10.8625	5.22	Yes	Yes	2	9	5
53	R:R:E111	R:R:R179	12.4434	8.14	No	No	0	4	5
54	R:R:F123	R:R:S167	11.4471	7.93	Yes	No	0	5	8
55	R:R:C230	R:R:S140	24.3902	6.89	No	No	0	5	7
56	R:R:I234	R:R:S140	23.485	3.1	Yes	No	0	8	7
57	R:R:I234	R:R:T144	17.9784	1.52	Yes	Yes	0	8	7
58	R:R:F309	R:R:L286	17.0135	10.96	Yes	No	0	5	4
59	R:R:F308	R:R:L286	14.8133	14.61	No	No	0	6	4
60	R:R:F308	R:R:P282	11.6042	4.33	No	No	0	6	9
61	R:R:P282	R:R:T281	10.8719	3.5	No	No	0	9	5
62	L:L:H2	L:L:W3	15.1779	9.52	Yes	Yes	1	0	0
63	L:L:W3	R:R:F309	14.1093	4.01	Yes	Yes	1	0	5
64	L:L:H2	R:R:Y283	14.4393	7.62	Yes	Yes	1	0	6
65	R:R:F309	R:R:Y283	28.8534	4.13	Yes	Yes	1	5	6
66	R:R:L219	R:R:Y284	34.2281	4.69	Yes	Yes	1	4	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D98	4.36	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K121	6.03	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y283	17.56	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F309	15.64	1	Yes	Yes	0	5	0	1
L:L:H2	R:R:T215	9.58	1	Yes	No	0	5	0	1
L:L:H2	R:R:L219	3.86	1	Yes	Yes	0	4	0	1
L:L:H2	R:R:Y283	7.62	1	Yes	Yes	0	6	0	1
L:L:H2	R:R:Y284	7.62	1	Yes	Yes	0	7	0	1
L:L:W3	R:R:Y283	9.65	1	Yes	Yes	0	6	0	1
L:L:W3	R:R:G287	8.44	1	Yes	No	0	5	0	1
L:L:W3	R:R:W291	14.99	1	Yes	Yes	0	4	0	1
L:L:W3	R:R:F309	4.01	1	Yes	Yes	0	5	0	1
L:L:S4	R:R:V197	6.46	0	No	No	0	5	0	1
L:L:Y5	R:R:Y290	5.96	0	Yes	Yes	0	4	0	1
L:L:Y5	R:R:V297	5.05	0	Yes	No	0	1	0	1
L:L:Y5	R:R:N305	12.79	0	Yes	No	0	3	0	1
L:L:Y5	R:R:F309	8.25	0	Yes	Yes	0	5	0	1
L:L:L7	R:R:F193	3.65	0	No	No	0	4	0	1
L:L:R8	R:R:P29	8.65	0	No	No	0	6	0	1
L:L:R8	R:R:N305	9.64	0	No	No	0	3	0	1
L:L:R8	R:R:H306	4.51	0	No	Yes	0	5	0	1
L:L:P9	R:R:N102	11.4	0	No	Yes	0	5	0	1
L:L:?11	R:R:D98	10.08	1	No	Yes	0	6	0	1
R:R:L28	R:R:P29	4.93	0	No	No	4	6	2	1
R:R:F193	R:R:L28	18.27	0	No	No	4	4	1	2
R:R:H306	R:R:S34	6.97	1	Yes	No	5	4	1	2
R:R:F307	R:R:S34	6.61	1	Yes	No	5	4	2	2
R:R:G35	R:R:H306	6.35	0	No	Yes	5	5	2	1
R:R:D98	R:R:R38	5.96	1	Yes	Yes	6	5	1	2
R:R:N102	R:R:R38	18.08	1	Yes	Yes	5	5	1	2
R:R:H306	R:R:R38	11.28	1	Yes	Yes	5	5	1	2
R:R:K121	R:R:V94	7.59	0	No	No	7	6	1	2
R:R:D98	R:R:F313	8.36	1	Yes	No	6	7	1	2
R:R:H306	R:R:N102	6.38	1	Yes	Yes	5	5	1	1
R:R:F193	R:R:Q106	16.4	0	No	No	4	5	1	2
R:R:K121	R:R:M125	4.32	0	No	No	7	7	1	2
R:R:T215	R:R:Y126	4.99	1	No	No	5	6	1	2
R:R:L219	R:R:Y126	7.03	1	Yes	No	4	6	1	2
R:R:I181	R:R:V197	4.61	0	No	No	2	5	2	1
R:R:H199	R:R:V197	15.22	0	No	No	4	5	2	1
R:R:N212	R:R:W291	27.12	0	No	Yes	5	4	2	1
R:R:L219	R:R:T215	4.42	1	Yes	No	4	5	1	1
R:R:F216	R:R:Y284	19.6	0	No	Yes	5	7	2	1
R:R:L219	R:R:Y284	4.69	1	Yes	Yes	4	7	1	1
R:R:W280	R:R:Y284	8.68	0	No	Yes	8	7	2	1
R:R:Y283	R:R:Y284	6.95	1	Yes	Yes	6	7	1	1
R:R:F309	R:R:Y283	4.13	1	Yes	Yes	5	6	1	1
R:R:A312	R:R:Y283	5.34	0	No	Yes	7	6	2	1
R:R:W291	R:R:Y284	4.82	0	Yes	Yes	4	7	1	1
R:R:F309	R:R:L286	10.96	1	Yes	No	5	4	1	2
R:R:M296	R:R:Y290	7.18	0	No	Yes	3	4	2	1
R:R:N305	R:R:S301	5.96	0	No	No	3	4	1	2
R:R:F307	R:R:H306	4.53	1	Yes	Yes	5	5	2	1
R:R:N102	R:R:V39	2.96	1	Yes	Yes	5	6	1	2
R:R:P294	R:R:Y290	2.78	0	No	Yes	3	4	2	1
R:R:H306	R:R:T32	2.74	1	Yes	No	5	4	1	2
L:L:G6	R:R:Y290	1.45	0	No	Yes	0	4	0	1
R:R:F292	R:R:W291	1	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9U4W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	263
Number of Links	284
Number of Hubs	36
Number of Links mediated by Hubs	129
Number of Communities	5
Number of Nodes involved in Communities	34
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	60872
Length Of Smallest Path	3
Average Path Length	14.4973
Length of Longest Path	30
Minimum Path Strength	1.475
Average Path Strength	7.38342
Maximum Path Strength	24.805
Minimum Path Correlation	0.7
Average Path Correlation	0.925262
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	45.2516
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.54
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	L-pyroglutamic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?11
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49922
Sequence	>9U4W_nogp_Chain_R N L P T L T L S G K I R V T V T F F L F L L S T A F N A S F L L K L Q K S R M K V L L K H L T L A N L L E T L I V M P L D G M W N I T V Q W Y A G E F L C K V L S Y L K L F S M Y A P A F M M V V I S L D R S L A I T R P L A V K S N S R L G R F M I G L A W L L S S I F A G P Q L Y I F R M I H L G F S Q C V T H G S F P Q W W H Q A F Y N F F T F S C L F I I P L L I M L I C N A K I M F T L T R V L Q N N I P R A R L R T L K M T V A F A A S F I V C W T P Y Y V L G I W Y W F D P E M V N R V S D P V N H F F F L F A F L N P C F D P L I Y G Y F S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7BR3	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Homo sapiens	Elagolix	-	-	2.79	2020-10-07	doi.org/10.1038/s41467-020-19109-w
	9U4W	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Sus scrofa	Gonadoliberin-1	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.18	2025-06-11	doi.org/10.1073/pnas.2500112122
	9U4W (No Gprot)	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Sus scrofa	Gonadoliberin-1	-		3.18	2025-06-11	doi.org/10.1073/pnas.2500112122
	9U4Y	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Xenopus laevis	Gonadoliberin-1	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.18	2025-06-11	doi.org/10.1073/pnas.2500112122
	9U4Y (No Gprot)	A	Peptide	Gonadotrophin Releasing Hormone	GnRH₁	Xenopus laevis	Gonadoliberin-1	-		3.18	2025-06-11	doi.org/10.1073/pnas.2500112122

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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You can also read or download a guide explaining the meaning of all files and numerical data.