Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 6.6375444
2A:A:H41 44116
3A:A:I207 3.922519
4A:A:F219 6.3245118
5A:A:F222 10.922517
6A:A:V224 3.405419
7A:A:Q227 4.154519
8A:A:K233 4.015419
9A:A:W234 5.106519
10A:A:F238 4.72143719
11A:A:F246 3.4775409
12A:A:F273 6.322599
13A:A:W277 10.085496
14A:A:W281 6.28833685
15A:A:L289 5.57409
16A:A:F290 4.556676219
17A:A:R342 4.872594
18A:A:F345 7.18408
19A:A:L346 3.2725494
20A:A:Y360 6.5125408
21A:A:F376 3.756676118
22A:A:R385 6.24405
23A:A:H387 4.374138
24A:A:Y391 5.294504
25B:B:T34 3.7525475
26B:B:V40 4.64833673
27B:B:I43 2.9725473
28B:B:H54 7.336549
29B:B:K57 10.6125489
30B:B:W63 5.055607
31B:B:S72 5.0225449
32B:B:I81 4.624267
33B:B:W82 9.05649
34B:B:T86 6.1225446
35B:B:K89 6.146549
36B:B:I93 3.675407
37B:B:L95 3.21754278
38B:B:W99 7.30429719
39B:B:N110 5.9454154
40B:B:Y111 6.355154
41B:B:L117 3.698519
42B:B:I123 3.05406
43B:B:Y124 4.388336276
44B:B:L139 5.2625409
45B:B:H142 6.32167619
46B:B:Y145 5.01429718
47B:B:R150 5.86254246
48B:B:F151 4.5925409
49B:B:D163 8.1125419
50B:B:L168 3.154556
51B:B:W169 6.75518
52B:B:F180 6.15833657
53B:B:H183 6.97659
54B:B:D186 4.9625419
55B:B:V187 4.315459
56B:B:L190 3.29254245
57B:B:F199 5.588559
58B:B:S201 3.7075459
59B:B:C204 4.47333617
60B:B:D205 6.9925459
61B:B:K209 10.215456
62B:B:L210 3.3225425
63B:B:W211 7.592558
64B:B:Q220 6.655427
65B:B:F222 5.658528
66B:B:H225 8.91333629
67B:B:D228 6.844519
68B:B:I232 4.754528
69B:B:F234 5.115405
70B:B:F235 8.4845186
71B:B:N237 8.214185
72B:B:F241 6.46526
73B:B:T243 5.4375428
74B:B:D247 6.8825429
75B:B:T249 5.67426
76B:B:R251 10.64428
77B:B:F253 5.8325426
78B:B:L255 2.88426
79B:B:D258 6.068527
80B:B:Q259 4.8525406
81B:B:Y264 6.076125
82B:B:C271 3.83405
83B:B:F278 4.42167607
84B:B:R283 7.77167679
85B:B:L284 4.3425475
86B:B:Y289 6.3556127
87B:B:D290 6.335486
88B:B:W297 5.35254128
89B:B:L300 5.6725476
90B:B:K301 5.48475
91B:B:H311 9.05754169
92B:B:R314 14.065488
93B:B:D323 7.30254257
94B:B:W332 10.81689
95B:B:D333 6.24754169
96B:B:L336 4.8125447
97B:B:W339 6.941676169
98G:G:L19 2.13409
99G:G:A23 2.37408
100G:G:R27 6.4075428
101G:G:M38 3.62474
102G:G:D48 7.47509
103G:G:L51 5.44476
104G:G:V54 3.955406
105G:G:N59 6.8154149
106G:G:P60 6.84149
107G:G:F61 4.712867148
108R:R:I19 3.78333630
109R:R:P20 3.515430
110R:R:V25 3.6125400
111R:R:Y37 6.39400
112R:R:N44 3.62400
113R:R:E54 3.735400
114R:R:L57 5.6454170
115R:R:Y62 5.875170
116R:R:F64 3.734500
117R:R:L68 3.655190
118R:R:D72 5.64254190
119R:R:T79 4.2425430
120R:R:I80 4.646500
121R:R:M83 5.0025430
122R:R:F87 6.822530
123R:R:F96 5.416100
124R:R:M103 4.285460
125R:R:I106 3.1275430
126R:R:F109 6.23400
127R:R:M112 5.3325400
128R:R:E113 5.6385190
129R:R:D123 6.88754130
130R:R:Y125 5.065400
131R:R:P131 4.56254130
132R:R:L132 3.7875400
133R:R:Y134 5.7525130
134R:R:F161 8.174560
135R:R:L168 2.6365290
136R:R:F170 4.244100
137R:R:H178 6.342530
138R:R:T179 4.0475430
139R:R:Y180 4.91429730
140R:R:H183 11.655460
141R:R:M184 3.175400
142R:R:Y200 6.9625460
143R:R:I208 3.7975460
144R:R:V209 4.134560
145R:R:D212 5.35400
146R:R:Y220 5.4125400
147R:R:F253 6.5475400
148R:R:Y254 5.68833600
149R:R:H264 7.486530
150R:R:R265 6.7325460
151R:R:I270 3.62754200
152R:R:P271 4.49254200
153R:R:H275 7.7025400
154R:R:I276 6.0725430
155R:R:Y282 4.844530
156R:R:N290 4.2825400
157R:R:Y294 6.595400
158R:R:I301 3.222500
159R:R:R304 8.234170
160L:L:?1 6.3881060
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:S74 22.04287.36NoNo099
2B:B:H54 B:B:S74 24.04489.76YesNo099
3B:B:H54 B:B:S72 14.02286.97YesYes499
4B:B:S72 B:B:W82 10.07842.47YesYes499
5B:B:I80 B:B:W82 10.071912.92NoYes089
6B:B:D76 B:B:L55 12.02825.43NoNo096
7A:A:K34 B:B:L55 10.02432.82NoNo046
8B:B:D83 B:B:R68 13.987911.91NoNo085
9B:B:R68 B:B:Y85 15.980722.64NoNo054
10G:G:N59 G:G:P60 10.2998.15YesYes1499
11B:B:N340 G:G:N59 60.926912.26NoYes099
12B:B:M45 B:B:N340 61.50932.8NoNo049
13B:B:L308 B:B:M45 57.23644.24NoNo074
14B:B:L308 B:B:W339 58.341410.25NoYes079
15B:B:T329 B:B:W339 29.70618.49NoYes089
16B:B:H311 B:B:T329 30.00764.11YesNo098
17B:B:D333 B:B:H311 60.04346.3YesYes1699
18B:B:D333 B:B:N313 61.00372.69YesNo097
19B:B:N313 B:B:W332 61.22493.39NoYes079
20A:A:W281 B:B:W332 43.82062.81YesYes859
21A:A:N279 A:A:W281 74.96313.39NoYes085
22A:A:L282 A:A:N279 74.96658.24NoNo098
23A:A:I235 A:A:L282 74.99624.28NoNo099
24A:A:I235 A:A:W234 75.02653.52NoYes099
25A:A:R231 A:A:W234 1009NoYes099
26A:A:L272 A:A:R231 99.86223.64NoNo089
27A:A:F246 A:A:L272 99.72373.65YesNo098
28A:A:F246 A:A:L289 98.77134.87YesYes099
29A:A:F345 A:A:L289 97.4610.96YesYes089
30A:A:F273 A:A:F345 97.15344.29YesYes098
31A:A:F273 A:A:W277 97.659113.03YesYes996
32A:A:H357 A:A:W277 97.24721.16NoYes076
33A:A:H357 A:A:R356 97.09613.39NoNo072
34A:A:R356 A:A:R389 96.849611.73NoNo024
35A:A:L394 A:A:R389 96.76852.43NoNo084
36A:A:L388 A:A:L394 96.43442.77NoNo088
37A:A:L388 A:A:L393 94.77912.77NoNo2288
38A:A:L393 A:A:Y391 95.48882.34NoYes084
39A:A:Y391 R:R:D123 28.81835.75YesYes040
40R:R:D123 R:R:F64 10.61197.17YesYes000
41G:G:F61 G:G:N59 48.19042.42YesYes1489
42B:B:K337 B:B:W339 29.66538.12NoYes1669
43B:B:H311 B:B:K337 30.007610.48YesNo1696
44B:B:K57 B:B:W332 24.807623.21YesYes899
45B:B:K57 B:B:Q75 26.16329.49YesNo099
46B:B:Q75 B:B:W99 15.44196.57NoYes099
47R:R:D123 R:R:Y134 25.1449.2YesYes1300
48A:A:H387 R:R:Y134 46.1536.53YesYes1380
49A:A:H387 A:A:I383 44.08942.65YesNo1388
50A:A:I383 R:R:L132 43.72062.85NoYes080
51A:A:H41 R:R:L132 21.05392.57YesYes060
52A:A:Y391 R:R:A127 21.34454YesNo040
53R:R:A127 R:R:Y134 21.14355.34NoYes000
54A:A:F219 A:A:H41 19.80617.92YesYes1186
55A:A:F376 R:R:L132 22.31714.87YesYes080
56A:A:F219 A:A:F376 19.83783.22YesYes1188
57A:A:C379 A:A:F219 37.97445.59NoYes088
58B:B:L117 B:B:W99 15.42185.69YesYes199
59B:B:Q75 B:B:Y59 11.22387.89NoNo098
60B:B:M101 B:B:Y59 11.11028.38NoNo098
61B:B:L117 B:B:Y145 12.02173.52YesYes198
62A:A:F290 A:A:I288 13.53423.77YesNo099
63A:A:F290 A:A:V375 32.94932.62YesNo099
64A:A:C379 A:A:V375 33.78771.71NoNo089
65B:B:L284 B:B:V296 22.26145.96YesNo055
66B:B:L286 B:B:V296 22.77632.98NoNo075
67B:B:L286 B:B:L318 23.03894.15NoNo076
68B:B:L318 B:B:S275 24.43214.5NoNo068
69B:B:S275 B:B:T274 24.69033.2NoNo088
70B:B:D290 B:B:T274 13.93365.78YesNo868
71B:B:R314 B:B:T274 11.01565.17YesNo888
72A:A:D378 A:A:I288 11.84717NoNo079
73A:A:D378 A:A:Y360 22.004310.34NoYes078
74A:A:F290 A:A:H362 14.38014.53YesNo099
75A:A:D378 A:A:H362 11.84947.56NoNo079
76A:A:Y391 R:R:R124 47.15867.2YesNo040
77B:B:C271 B:B:D290 27.13163.11YesYes056
78B:B:C271 B:B:Y289 26.07154.03YesYes057
79B:B:W297 B:B:Y289 23.60014.82YesYes1287
80B:B:W297 B:B:Y264 23.49610.61YesYes1285
81B:B:M262 B:B:Y264 14.41898.38NoYes1245
82B:B:L30 B:B:M262 14.23215.65NoNo054
83B:B:L261 B:B:L30 14.03374.15NoNo055
84B:B:L261 G:G:V30 13.20654.47NoNo058
85B:B:Q259 G:G:V30 13.00685.73YesNo068
86B:B:C25 B:B:Q259 12.6366.1NoYes036
87B:B:C25 G:G:R27 12.4355.57NoYes038
88B:B:D258 G:G:R27 11.8214.76YesYes278
89B:B:R49 G:G:F61 23.717.48NoYes1478
90B:B:R49 B:B:T87 23.39865.17NoNo075
91B:B:L51 B:B:W82 12.540318.22NoYes499
92B:B:L51 B:B:T87 23.07974.42NoNo095
93B:B:S84 G:G:F61 15.46415.28NoYes058
94B:B:S84 B:B:W63 15.13992.47NoYes057
95B:B:L70 B:B:W82 12.80626.83NoYes059
96B:B:L70 B:B:W63 13.13247.97NoYes057
97B:B:S147 B:B:Y145 14.93522.54NoYes098
98B:B:S147 B:B:S160 14.61613.26NoNo096
99B:B:S97 B:B:W99 15.35642.47NoYes089
100B:B:D118 B:B:S97 14.812411.78NoNo098
101B:B:D118 B:B:I120 14.2682.8NoNo096
102B:B:E138 B:B:I120 12.63294.1NoNo066
103B:B:E138 B:B:S122 11.54124.31NoNo068
104B:B:S122 B:B:Y124 10.99493.82NoYes086
105B:B:G162 B:B:Y145 15.59155.79NoYes198
106B:B:G162 B:B:S161 15.46133.71NoNo199
107B:B:H142 B:B:S161 13.548215.34YesNo199
108R:R:R124 R:R:Y220 46.98115.14NoYes000
109R:R:I216 R:R:Y220 43.07462.42NoYes000
110R:R:I216 R:R:Y254 42.89072.42NoYes000
111R:R:F253 R:R:Y254 30.41610.32YesYes000
112R:R:F253 R:R:Y282 32.90533.09YesYes000
113R:R:Y180 R:R:Y282 28.77892.98YesYes300
114R:R:H178 R:R:Y180 13.10149.8YesYes300
115R:R:V209 R:R:Y254 11.19785.05YesYes000
116B:B:L336 B:B:L51 10.22565.54YesNo479
117A:A:W234 B:B:Y145 23.07514.82YesYes198
118A:A:W281 B:B:D290 27.46273.35YesYes856
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:H107 R:R:M103 5.25 0 No Yes 0 0 1 2
R:R:F161 R:R:M103 2.49 6 Yes Yes 0 0 1 2
R:R:L165 R:R:M103 2.83 6 No Yes 0 0 2 2
R:R:H183 R:R:M103 6.57 6 Yes Yes 0 0 1 2
R:R:H107 R:R:V158 2.77 0 No No 0 0 1 2
L:L:?1 R:R:H107 12.26 6 Yes No 0 0 0 1
L:L:?1 R:R:T110 2.81 6 Yes No 0 0 0 1
R:R:I208 R:R:R153 3.76 6 Yes No 0 0 1 2
R:R:I208 R:R:L157 4.28 6 Yes No 0 0 1 2
R:R:F161 R:R:V158 2.62 6 Yes No 0 0 1 2
R:R:F161 R:R:H183 23.76 6 Yes Yes 0 0 1 1
R:R:F161 R:R:Y200 6.19 6 Yes Yes 0 0 1 2
L:L:?1 R:R:F161 5.81 6 Yes Yes 0 0 0 1
R:R:H183 R:R:L165 7.71 6 Yes No 0 0 1 2
L:L:?1 R:R:H183 8.58 6 Yes Yes 0 0 0 1
R:R:I198 R:R:R265 8.77 0 No Yes 0 0 2 1
R:R:L202 R:R:R265 3.64 6 No Yes 0 0 2 1
R:R:F266 R:R:L202 2.44 6 No No 0 0 2 2
R:R:I208 R:R:V209 3.07 6 Yes Yes 0 0 1 1
L:L:?1 R:R:I208 4.08 6 Yes Yes 0 0 0 1
R:R:V209 R:R:Y254 5.05 6 Yes Yes 0 0 1 2
R:R:F258 R:R:V209 7.87 0 No Yes 0 0 2 1
L:L:?1 R:R:V209 2.84 6 Yes Yes 0 0 0 1
R:R:A257 R:R:F261 2.77 0 No No 0 0 2 1
L:L:?1 R:R:F261 16.26 6 Yes No 0 0 0 1
R:R:F266 R:R:R265 6.41 6 No Yes 0 0 2 1
L:L:?1 R:R:R265 8.11 6 Yes Yes 0 0 0 1
R:R:G210 R:R:V209 1.84 0 No Yes 0 0 2 1
L:L:?1 R:R:G201 1.63 6 Yes No 0 0 0 1
L:L:?1 R:R:A205 1.5 6 Yes No 0 0 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription

PDB Summary
PDB 8HTI
Class A
SubFamily Olfactory receptors
Type Olfactory
SubType OR52C
Species Homo Sapiens
Ligand Ocatnoic Acid
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.97
Date 2023-12-20
D.O.I. 10.1038/s41467-023-43983-9
Net Summary
Imin 2.41
Number of Linked Nodes 786
Number of Links 957
Number of Hubs 160
Number of Links mediated by Hubs 581
Number of Communities 29
Number of Nodes involved in Communities 228
Number of Links involved in Communities 319
Path Summary
Number Of Nodes in MetaPath 119
Number Of Links MetaPath 118
Number of Shortest Paths 1038125
Length Of Smallest Path 3
Average Path Length 31.3961
Length of Longest Path 60
Minimum Path Strength 1.155
Average Path Strength 5.93385
Maximum Path Strength 24.6
Minimum Path Correlation 0.7
Average Path Correlation 0.980032
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 48.3556
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.2369
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeOCA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeOCA
NameCaprylic acid
SynonymsAcidum octanoicum
Identifieroctanoic acid
FormulaC8 H16 O2
Molecular Weight144.211
SMILESCCCCCCCC(=O)O
PubChem135372298
Formal Charge0
Total Atoms26
Total Chiral Atoms0
Total Bonds25
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8HTI_Chain_A
RNEEKAQRE ANKKIEKQL QKDKQVYRA THRLLLLGI FETKFQVDK 
VNFHMFDVG GQRDERRKW IQCFNDVTA IIFVVRLQE ALNLFKSIW 
NNRWLRTIS VILFLKYFI RDEFLRIST ASGDGRHYC YPHFTTENI 
RRVFNDCRD IIQRMHLRQ YELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HTI_Chain_B
QEAEQLKNQ IRDARKACA DATLSQITN NIDPVGRIQ MRTRRTLRG 
HLAKIYAMH WGTDSRLLV SASQDGKLI IWDSYTTNK VHAIPLRSS 
WVMTCAYAP SGNYVACGG LDNICSIYN LKTVRVSRE LAGHTGYLS 
CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH TGDVMSLSL 
APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD INAICFFPN 
GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI TSVSFSKSG 
RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL GVTDDGMAV 
ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HTI_Chain_G
AQARKLVEQ LKMEANIDR IKVSKAAAD LMAYCEAHA KEDPLLTPV 
PASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProt-
Sequence
>8HTI_Chain_R
SFHPSSFLL VGIPGLESV HIWISIPFC AMYLIALLG NSTLLFVIK 
TERSLHEPM YYFLAMLAA TDLVLSTST IPKMLAIFW FNLKEISFD 
ACLTQMFFI HSFTGMESG VLLAMAFDR YVAICYPLR YTTILTNKV 
IGKIGMAVV LRAVLLVIP FPFLLKRLP FCGTNIIPH TYCEHMGVA 
KLACADIKV NIIYGLFVA LLIVGLDVI LIALSYVLI LRAVFRLPS 
QDARLKALS TCGSHICVI LAFYTPAFF SFLTHRFGH HIPPYIHIL 
LANLYLLVP PMLNPIIYG VKTKQIRER VLKIFF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HTIAOlfactory receptorsOlfactoryOR52CHomo sapiensOcatnoic Acid-Gs/&β;1/&γ;22.972023-12-2010.1038/s41467-023-43983-9
8J46AOlfactory receptorsOlfactoryOR52CHomo sapiens---3.662023-12-2010.1038/s41467-023-43983-9
8W77AOlfactory receptorsOlfactoryOR52CHomo sapiens---3.612023-12-2010.1038/s41467-023-43983-9




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