Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 2.4625401
2A:A:V34 4.08515
3A:A:K46 4.144249
4A:A:G183 3.0675408
5A:A:I184 5.7875428
6A:A:F189 10.0575419
7A:A:F191 5.54515
8A:A:L194 3.23414
9A:A:Y195 7.665424
10A:A:F196 5.81333617
11A:A:M198 4.692517
12A:A:F199 8.15667626
13A:A:V201 4.6925429
14A:A:Q204 4.19667629
15A:A:K210 5.69529
16A:A:W211 6.662529
17A:A:F215 5.396529
18A:A:F223 6.975409
19A:A:D231 6.64469
20A:A:R242 10.7875469
21A:A:F250 6.1075409
22A:A:C254 3.2145175
23A:A:W258 5.4865115
24A:A:F259 6.0385239
25A:A:I265 3.61519
26A:A:L266 3.9854149
27A:A:F267 3.84419
28A:A:F274 4.3508
29A:A:S281 3.06467
30A:A:P282 4.2425465
31A:A:L283 4.23477
32A:A:Y287 5.65778
33A:A:Y290 6.62577
34A:A:Y302 6.20667676
35A:A:F307 4.864148
36A:A:N311 6.06254177
37A:A:Y320 6.77857718
38A:A:T321 6.46254144
39A:A:D341 9.5225417
40A:A:K345 8.315405
41A:A:L348 4.34408
42A:A:Y354 3.0325405
43B:B:L30 3.60254265
44B:B:M45 4.365494
45B:B:H54 7.505717109
46B:B:Y59 6.684118
47B:B:W63 7.312507
48B:B:D76 5.3425109
49B:B:I80 9.954108
50B:B:I81 3.7365127
51B:B:W82 9.636676109
52B:B:K89 7.4425109
53B:B:I93 5.975127
54B:B:W99 7.0025829
55B:B:N110 6.9154134
56B:B:Y111 6.49254134
57B:B:C114 3.472508
58B:B:G115 2.8175409
59B:B:D118 4.64409
60B:B:I123 4.064556
61B:B:Y124 6.394126
62B:B:V133 5.0354124
63B:B:L139 5.5175409
64B:B:H142 7.668559
65B:B:Y145 5.09333628
66B:B:R150 5.575406
67B:B:F151 7.235459
68B:B:L152 5.0425403
69B:B:D163 7.29559
70B:B:L168 3.5975406
71B:B:W169 9.278558
72B:B:T173 5.1854285
73B:B:Q176 7.99454
74B:B:F180 7.7375487
75B:B:H183 7.942589
76B:B:V187 4.99489
77B:B:R197 6.054185
78B:B:L198 4.56754183
79B:B:K209 7.8625486
80B:B:W211 9.678588
81B:B:D212 7.9754189
82B:B:F222 7.0375438
83B:B:H225 9.32167639
84B:B:I229 8.51437
85B:B:I232 5.62538
86B:B:F235 6.038336196
87B:B:P236 6.394197
88B:B:F241 6.33333636
89B:B:T243 7.8725438
90B:B:D247 7.49409
91B:B:T249 6.4825436
92B:B:R251 12.786538
93B:B:F253 5.43636
94B:B:E260 9.2175436
95B:B:Y264 7.538505
96B:B:F278 6.386676197
97B:B:S281 3.0275409
98B:B:R283 6.6085279
99B:B:L285 7.035406
100B:B:Y289 6.4825157
101B:B:D290 5.2406
102B:B:K301 4.2925405
103B:B:R304 6.9425155
104B:B:H311 7.568599
105B:B:R314 9.78754118
106B:B:M325 5.5125445
107B:B:W332 10.17867119
108B:B:D333 7.535499
109B:B:K337 6.322596
110B:B:W339 9.836599
111B:B:N340 4.5525449
112G:G:Y40 10.4954196
113G:G:H44 8.7325406
114G:G:D48 5.83509
115G:G:F61 4.89714748
116L:L:V74 6.7409
117L:L:P75 5.56409
118L:L:L78 5.69409
119L:L:V81 3.905409
120R:R:Y40 6.398336307
121R:R:F44 7.4475407
122R:R:I68 3.395408
123R:R:F71 3.408507
124R:R:S78 4.394318
125R:R:F82 8.1125406
126R:R:E93 5.4625404
127R:R:W99 8.832508
128R:R:T101 4.8145217
129R:R:Y111 6.402506
130R:R:R131 4.852509
131R:R:Y132 6.6025338
132R:R:R142 2.895405
133R:R:R172 7.82754205
134R:R:P181 6.18254224
135R:R:C183 4.11754209
136R:R:F204 10.2254168
137R:R:L208 1.983336166
138R:R:Y215 6.68509
139R:R:H232 11.64404
140R:R:N233 7.1525414
141R:R:W254 5.971676169
142R:R:I265 3.675404
143R:R:P276 2.9325402
144R:R:F292 7.15754307
145R:R:C296 3.47408
146R:R:Y302 3.7375409
147R:R:F305 5.0225406
148R:R:I313 4.215407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:R68 14.147115.48NoNo085
2B:B:R68 B:B:Y85 14.41326.75NoNo054
3B:B:Y85 G:G:F61 14.94426.19NoYes048
4B:B:N340 G:G:F61 17.2283.62YesYes498
5B:B:M325 B:B:N340 18.20642.8YesYes459
6B:B:M325 G:G:P49 28.19696.71YesNo057
7G:G:D48 G:G:P49 28.4484.83YesNo097
8B:B:S279 G:G:D48 58.98358.83NoYes099
9B:B:L284 B:B:S279 59.19744.5NoNo059
10B:B:L284 B:B:V296 59.41372.98NoNo055
11B:B:L286 B:B:V296 60.07074.47NoNo075
12B:B:L286 B:B:L318 67.35074.15NoNo076
13B:B:L318 B:B:S275 68.19753NoNo068
14B:B:S275 B:B:T274 68.40874.8NoNo088
15B:B:S316 B:B:T274 67.583.2NoNo098
16B:B:S316 B:B:W332 67.78647.41NoYes099
17B:B:W332 B:B:Y59 68.70232.89YesYes1198
18B:B:Q75 B:B:Y59 69.864815.78NoYes098
19B:B:Q75 B:B:W99 52.19564.38NoYes099
20A:A:F215 B:B:W99 34.01095.01YesYes299
21A:A:F215 A:A:W211 37.40334.01YesYes299
22A:A:R208 A:A:W211 99.52787NoYes099
23A:A:L249 A:A:R208 99.54783.64NoNo089
24A:A:F223 A:A:L249 99.55877.31YesNo098
25A:A:F223 A:A:L266 93.84773.65YesYes099
26A:A:L266 A:A:T321 94.72662.95YesYes1494
27A:A:T321 R:R:K231 94.66724.5YesNo044
28R:R:H232 R:R:K231 94.647513.1YesNo044
29A:A:Y320 R:R:H232 13.508919.6YesYes084
30A:A:I265 A:A:Y320 15.7824.84YesYes198
31A:A:F307 A:A:M247 18.58743.73YesNo086
32A:A:M247 A:A:Y287 16.78388.38NoYes068
33A:A:F307 A:A:L266 13.76374.87YesYes1489
34A:A:C214 B:B:Q75 17.88099.16NoNo089
35A:A:C214 B:B:L117 18.02154.76NoNo089
36A:A:Q204 B:B:L117 36.77253.99YesNo099
37A:A:G183 A:A:Q204 99.09573.29YesYes089
38B:B:L117 B:B:W99 18.65335.69NoYes099
39A:A:G183 B:B:N119 1003.39YesNo089
40A:A:E318 R:R:H232 40.58398.62NoYes044
41A:A:E318 A:A:K345 40.49796.75NoYes045
42A:A:K345 R:R:L236 85.52737.05YesNo057
43A:A:Y354 R:R:L236 85.32322.34YesNo057
44R:R:H232 R:R:K235 40.58375.24YesNo046
45A:A:K345 R:R:K235 40.49772.87YesNo056
46A:A:Y354 R:R:S239 81.60993.82YesNo057
47A:A:L348 R:R:S239 80.77467.51YesNo087
48A:A:L348 A:A:L353 78.03424.15YesNo087
49A:A:L353 R:R:R131 59.68116.07NoYes079
50A:A:L353 R:R:I243 18.15837.14NoNo077
51B:B:G144 B:B:N119 99.86713.39NoNo089
52B:B:D163 B:B:G144 99.73396.71YesNo098
53B:B:D163 B:B:H142 98.73665.04YesYes599
54B:B:H142 B:B:W169 93.23319.52YesYes598
55B:B:L139 B:B:W169 92.713510.25YesYes098
56B:B:G174 B:B:L139 93.42883.42NoYes049
57B:B:G174 B:B:T173 93.28573.64NoYes045
58B:B:D170 B:B:T173 92.40525.78NoYes2895
59B:B:D170 B:B:T177 92.42247.23NoNo094
60B:B:L168 B:B:T177 92.13282.95YesNo064
61B:B:L168 B:B:V158 90.95284.47YesNo065
62B:B:L190 B:B:V158 90.3642.98NoNo055
63B:B:C148 B:B:L190 89.38357.94NoNo065
64B:B:C148 B:B:S160 89.23443.44NoNo066
65B:B:C166 B:B:S160 29.49433.44NoNo886
66B:B:C166 B:B:F180 29.31264.19NoYes887
67B:B:F180 B:B:W211 28.743213.03YesYes878
68B:B:C218 B:B:W211 57.21177.84NoYes858
69B:B:C218 G:G:Q18 85.31094.58NoNo059
70B:B:M217 G:G:Q18 83.54355.44NoNo039
71B:B:E215 B:B:M217 81.18388.12NoNo033
72B:B:D212 B:B:E215 43.02345.2YesNo1893
73B:B:D212 B:B:L198 36.97084.07YesYes1893
74B:B:L198 B:B:L210 72.75096.92YesNo035
75B:B:L210 B:B:L255 71.5456.92NoNo056
76B:B:F241 B:B:L255 70.33953.65YesNo066
77B:B:F222 B:B:F241 32.77818.57YesYes386
78B:B:D258 B:B:F222 30.41938.36NoYes378
79B:B:D258 B:B:R22 29.20819.53NoNo076
80B:B:I18 B:B:R22 26.77917.52NoNo076
81B:B:I18 G:G:A23 25.56433.25NoNo078
82B:B:L14 G:G:A23 24.34931.58NoNo088
83B:B:L14 B:B:Q17 21.91857.99NoNo084
84B:B:Q13 B:B:Q17 10.96853.84NoNo014
85B:B:S160 B:B:V187 59.59074.85NoYes869
86B:B:H183 B:B:V187 58.75738.3YesYes899
87B:B:H183 B:B:W211 28.842212.7YesYes898
88B:B:H183 B:B:K209 29.24411.79YesYes896
89B:B:C218 B:B:K209 28.68774.85NoYes856
90B:B:E215 B:B:R219 37.56976.98NoNo1835
91B:B:L198 B:B:R219 36.97193.64YesNo1835
92B:B:S281 G:G:D48 34.15875.89YesYes099
93B:B:S281 G:G:H44 28.94942.79YesYes096
94G:G:H44 G:G:Y40 27.945619.6YesYes066
95B:B:F235 G:G:Y40 13.48083.09YesYes1966
96B:B:F235 B:B:F278 12.43979.65YesYes1967
97B:B:F278 B:B:L285 22.771913.4YesYes076
98B:B:L285 B:B:Y264 20.15047.03YesYes065
99B:B:M262 B:B:Y264 10.11687.18NoYes045
100B:B:P236 G:G:Y40 12.95214.17YesYes1976
101B:B:F278 B:B:P236 12.42897.22YesYes1977
102B:B:D83 B:B:L69 10.93774.07NoNo085
103B:B:I81 B:B:L69 10.39962.85YesNo075
104B:B:F241 B:B:F253 27.91387.5YesYes366
105R:R:R131 R:R:Y302 32.92433.09YesYes099
106R:R:N298 R:R:Y302 31.86255.81NoYes099
107R:R:L75 R:R:N298 31.62286.87NoNo099
108R:R:D79 R:R:L75 31.14774.07NoNo099
109R:R:D79 R:R:S295 30.67978.83NoNo099
110R:R:F82 R:R:S295 30.44657.93YesNo069
111R:R:F292 R:R:F82 23.83038.57YesYes076
112R:R:F292 R:R:Y40 21.933810.32YesYes3077
113R:R:E93 R:R:Y40 17.8616.73YesYes047
114R:R:E93 R:R:W89 17.07873.27YesNo046
115R:R:K92 R:R:W89 12.85189.28NoNo056
116L:L:V74 R:R:K92 12.32693.04YesNo095
117L:L:V74 R:R:Y182 10.338215.14YesNo093
118R:R:P181 R:R:Y182 10.070411.13YesNo043
119R:R:R131 R:R:Y215 18.2317.2YesYes099
120R:R:S128 R:R:Y215 34.676110.17NoYes099
121R:R:I211 R:R:S128 34.19377.74NoNo089
122R:R:F250 R:R:I211 31.77943.77NoNo098
123R:R:F250 R:R:W254 23.940911.02NoYes099
124R:R:M117 R:R:W254 18.74655.82NoYes079
125L:L:L78 R:R:M117 18.25985.65YesNo097
126L:L:L78 L:L:P79 10.8294.93YesNo099
127L:L:P79 R:R:S114 10.31623.56NoNo095
128R:R:I243 R:R:Y215 17.92798.46NoYes079
129A:A:Q204 A:A:W211 61.92948.76YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:E68 R:R:K187 12.15 0 No No 2 4 0 1
L:L:P69 R:R:K186 3.35 0 No No 3 3 0 1
L:L:W72 R:R:E173 7.63 0 No No 8 4 0 1
L:L:W72 R:R:T175 8.49 0 No No 8 2 0 1
L:L:W72 R:R:K186 5.8 0 No No 8 3 0 1
L:L:V74 R:R:K92 3.04 0 Yes No 9 5 0 1
L:L:V74 R:R:Y182 15.14 0 Yes No 9 3 0 1
L:L:V74 R:R:A184 5.09 0 Yes No 9 3 0 1
L:L:P75 R:R:R172 7.21 0 Yes Yes 9 5 0 1
L:L:L78 R:R:M117 5.65 0 Yes No 9 7 0 1
L:L:L78 R:R:F257 7.31 0 Yes No 9 7 0 1
L:L:L78 R:R:F292 4.87 0 Yes Yes 9 7 0 1
L:L:P79 R:R:S114 3.56 0 No No 9 5 0 1
L:L:Q80 R:R:Q281 5.12 0 No No 9 4 0 1
L:L:V81 R:R:K192 4.55 0 Yes No 9 4 0 1
L:L:V81 R:R:S196 3.23 0 Yes No 9 5 0 1
L:L:V81 R:R:I265 6.14 0 Yes Yes 9 4 0 1
R:R:L86 R:R:Y40 9.38 30 No Yes 8 7 2 1
R:R:E93 R:R:Y40 6.73 0 Yes Yes 4 7 2 1
R:R:P289 R:R:Y40 6.95 0 No Yes 5 7 2 1
R:R:F292 R:R:Y40 10.32 30 Yes Yes 7 7 1 1
R:R:F292 R:R:F82 8.57 30 Yes Yes 7 6 1 2
R:R:F292 R:R:L86 4.87 30 Yes No 7 8 1 2
R:R:K92 R:R:W89 9.28 0 No No 5 6 1 2
R:R:E93 R:R:W89 3.27 0 Yes No 4 6 2 2
R:R:G97 R:R:K92 3.49 0 No No 4 5 2 1
R:R:C106 R:R:R172 4.18 20 No Yes 9 5 2 1
R:R:C106 R:R:C183 7.28 20 No Yes 9 9 2 2
R:R:S110 R:R:T168 3.2 0 No No 5 4 2 2
R:R:R172 R:R:S110 17.13 20 Yes No 5 5 1 2
R:R:S114 R:R:T168 9.59 0 No No 5 4 1 2
R:R:M117 R:R:W254 5.82 0 No Yes 7 9 1 2
R:R:C183 R:R:R172 2.79 20 Yes Yes 9 5 2 1
R:R:I177 R:R:T175 4.56 22 No No 1 2 2 1
R:R:P181 R:R:T175 6.99 22 Yes No 4 2 2 1
R:R:I177 R:R:P181 3.39 22 No Yes 1 4 2 2
R:R:P181 R:R:Y182 11.13 22 Yes No 4 3 2 1
R:R:E185 R:R:K186 10.8 0 No No 5 3 2 1
R:R:A188 R:R:K187 3.21 29 No No 4 4 2 1
R:R:K187 R:R:L193 2.82 29 No No 4 2 1 2
R:R:A188 R:R:K192 4.82 29 No No 4 4 2 1
R:R:A188 R:R:L193 3.15 29 No No 4 2 2 2
R:R:I265 R:R:L193 4.28 0 Yes No 4 2 1 2
R:R:I265 R:R:L197 2.85 0 Yes No 4 4 1 2
R:R:F257 R:R:K261 3.72 0 No No 7 5 1 2
R:R:F257 R:R:M284 4.98 0 No No 7 4 1 2
L:L:A77 R:R:Y40 2.67 0 No Yes 9 7 0 1
R:R:L36 R:R:Y40 2.34 0 No Yes 5 7 2 1
R:R:G165 R:R:S114 1.86 0 No No 7 5 2 1
L:L:V81 R:R:A264 1.7 0 Yes No 9 4 0 1
R:R:A278 R:R:Q281 1.52 0 No No 1 4 2 1
R:R:K192 R:R:T189 1.5 0 No No 4 3 1 2
R:R:I265 R:R:L269 1.43 0 Yes No 4 1 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
47.62Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
47.37Single8JJPChemerin-98JJP-CML2-Chemerin-9-Gi1/β1/γ2
47.06Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
44.44Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
42.11Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
42.11Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
40.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
40.00Single9ECJS-geranylgeranyl-L-glutathione9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
39.13Single8K6ONeuropeptide-Y8K6O-Y1-Neuropeptide-Y-Gi2/β1/γ1
39.13Single9IK8Pasireotide9IK8-SST1-Pasireotide-Gi1/β1/γ2
38.89Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
38.89Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
38.89Single8ZQEGPR15L(CT)8ZQE-GPR15-GPR15L(CT)-Gi1/β1/γ1
38.89Consensusa3_onOrthosteric Liganda3a_on
38.10Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
37.50Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
37.50Single9UYIChemerin-99UYI-CML2-Chemerin-9-Arrestin2
37.50Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.50Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
37.50Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
37.04Single8ZH8QRFP268ZH8-QRFP-QRFP26-Gq/β1/γ1
36.84Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
36.84Consensusa3_on_gpOrthosteric Liganda3a_on_gp
36.84Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.84Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.36Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
36.36Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
36.36Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.36Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.00Single7F6G(Sar1)-Angiotensin II7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
36.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
36.00Single8X8LCortistatin-148X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
36.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
36.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
36.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
35.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
35.00Single6J21Aprepitant6J21-NK1-Aprepitant
35.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
35.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
35.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
34.78Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
34.78Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
34.78Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
34.78Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
34.78Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
34.78Single9L3YChemerin9L3Y-CML2-Chemerin-Gi1/β1/γ2
34.78Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
34.78Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.78Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.78Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
34.62Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.62Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Single3QAKUK-4320973QAK-A2A-UK-432097
33.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single6DO1(Sar1,Ile8)-Angiotensin II6DO1-AT1-(Sar1,Ile8)-Angiotensin II
33.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Single7F61PF-036547467F61-H3-PF-03654746
33.33Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
33.33Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
33.33Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
33.33Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
33.33Single9JH3CMF-0199JH3-Apelin; Apelin-CMF-019-Gi1/β1/γ2
33.33Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
33.33Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
33.33Single9ME1CXCL129ME1-CXCR4-CXCL12
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
33.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
33.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.26Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
32.14Single7EIBKallidin-des-Arg107EIB-BK1-Kallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
32.14Single9KDFRES-701-39KDF-ETB-RES-701-3
32.14Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
32.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.00Consensusangiotensin_onOrthosteric Ligandat1_on
32.00Consensusat1_onOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
32.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
32.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.82Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
31.82Single7EZCUK-4320977EZC-A2A-UK-432097
31.82Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single8ZPLHF511168ZPL-CXCR4-HF51116
31.82Single9UYMChemerin-99UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
31.82Consensuschemerin_onOrthosteric Ligandcml1_on
31.82Consensusprostanoid_offOrthosteric Ligandep_off dp_off
31.58Single4EJ4Naltrindole4EJ4-δ-Naltrindole
31.58Single8Y71A1D6F8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
31.58Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
31.58Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
31.25Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
31.25Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
31.03Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
31.03Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
31.03Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
31.03Consensusbradykinin_onOrthosteric Ligandbk2_on
31.03Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
31.03Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
30.77Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
30.77Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.77Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.77Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
30.43Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
30.43Single7XN9L-0545227XN9-SST2-L-054522
30.43Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
30.43Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
30.43Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
30.43Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
30.43Single9KX6C5a-des-Arg9KX6-C5a1-C5a-des-Arg-Go/β1/γ2
30.43Single9M0RNeuropeptide-VF9M0R-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
30.43Single9UMJEP549UMJ-C3aB-EP54-Go/β1/γ2
30.43Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.43Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
30.43Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
30.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
30.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
30.00Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
30.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
30.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
30.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
30.00Single9KUVCMPD6449KUV-Apelin-CMPD644-Arrestin2
30.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
30.00Consensusdp_offOrthosteric Liganddp2_off
30.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
30.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
29.63Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
29.63Single8XQEApelin-138XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
29.63Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
29.63Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
29.63Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.41Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
29.41Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
29.41Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
29.41Single8W892-Phenylethylamine8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2
29.41Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Single4IARErgotamine4IAR-5-HT1B-Ergotamine
29.17Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
29.17Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
29.17Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
29.17Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
29.17Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
29.17Single8WDTphotoNECA8WDT-A2A-photoNECA
29.17Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
29.17Single9MEJGp1209MEJ-CXCR4-Gp120
29.17Single9UMRC5a-pep9UMR-C5a1-C5a-pep-Go/β1/γ2
29.17Single9UYJChemerin-99UYJ-CML2-Chemerin-9-Arrestin2
29.17Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
29.17Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
29.17Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
28.57Single6OS1TRV0266OS1-AT1-TRV026
28.57Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
28.57Single7TUYGSK682753A7TUY-GPR183-GSK682753A
28.57Single8I2GPubChem 675302408I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
28.57Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
28.57Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
28.57Single8UGWCGS216808UGW-A2A-CGS21680
28.57Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
28.57Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
28.57Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.57Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
28.57Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
28.57Single8XZICMF-0198XZI-Apelin; Apelin-CMF-019-Gi1/β1/γ2
28.57Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single9IK9Lanreotide9IK9-SST1-Lanreotide-Gi1/β1/γ2
28.57Single9KUXCMPD6449KUX-Apelin; Apelin-CMPD644-Arrestin2
28.57Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
28.57Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
28.57Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
28.57Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
28.57Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
28.57Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
28.57Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
28.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
28.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
28.00Single7RKMCX3CL17RKM-US28-CX3CL1-Gi1/β1/γ2
28.00Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
28.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
28.00Single8JZZC5a-des-Arg8JZZ-C5a1-C5a-des-Arg-Go/β1/γ2
28.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
28.00Single8WSSMCH8WSS-MCH1-MCH-Gi1/β1/γ1
28.00Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
28.00Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
28.00Single9L60Dynorphin9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
28.00Single9UMXEP549UMX-C5a1-EP54-Go/β1/γ2
28.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
28.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
28.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
27.78Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
27.78Single6AKYMaraviroc6AKY-CCR5-Maraviroc
27.78Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
27.78Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
27.78Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8FYXBuspirone8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1
27.78Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
27.78Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
27.78Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
27.78Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
27.78Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.78Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
27.78Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
27.78Single9PXUNaloxone9PXU-μ-Naloxone-Na
27.78Single9VJ5Gepirone9VJ5-5-HT1A-Gepirone-Go/β1/γ2
27.78Single9VJEBuspirone9VJE-5-HT1A-Buspirone-Go/β1/γ2
27.78Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.78Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.59Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
27.59Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
27.59Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
27.59Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
27.59Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
27.59Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
27.27Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
27.27Single6DRYMethylergometrine6DRY-5-HT2B-Methylergometrine
27.27Single6OS0Angiotensin II6OS0-AT1-Angiotensin II
27.27Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
27.27Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
27.27Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
27.27Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
27.27Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single7W0LPubChem 1227019087W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
27.27Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
27.27Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
27.27Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
27.27Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
27.27Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8ID9Icosapent8ID9-FFA4-Icosapent-Gi1/β1/γ2
27.27Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
27.27Single8JWY2-1188JWY-A2A-2-118
27.27Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
27.27Single8T3QDoconexent8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Single8XWACXCL18XWA-CXCR2-CXCL1
27.27Single8XWMCXCL68XWM-CXCR2-CXCL6
27.27Single8XWSCXCL58XWS-CXCR2-CXCL5
27.27Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
27.27Single9CM3TUG-13759CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
27.27Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
27.27Single9L3WChemerin9L3W-CML1-Chemerin-Gi1/β1/γ2
27.27Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
27.27Single9YDQDADLE9YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
27.27Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
27.27Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
27.27Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
27.27Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
27.27Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
27.27Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
27.27Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
27.27Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single3OE0CVX153OE0-CXCR4-CVX15
26.92Single5WF5UK-4320975WF5-A2A-UK-432097
26.92Single6PT2KGCHM076PT2-δ-KGCHM07
26.92Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
26.92Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
26.92Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single8XZGApelin-138XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
26.92Single9M1ONeuropeptide-FF9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
26.92Single9MEUCXCL129MEU-CXCR4-CXCL12
26.92Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.92Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
26.92Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
26.92Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
26.67Single6IGLIRL16206IGL-ETB-IRL1620
26.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
26.32Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
26.32Single4MBSMaraviroc4MBS-CCR5-Maraviroc
26.32Single6MH8ZM-2413856MH8-A2A-ZM-241385
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
26.32Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
26.32Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
26.32Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
26.32Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
26.32Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
26.32Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
26.32Single7UTZDPPC7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
26.32Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
26.32Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
26.32Single8IHKAcifran8IHK-HCA3-Acifran
26.32Single8JEIPubChem 117155568JEI-HCAR3-PubChem 11715556-Gi1/β1/γ2
26.32Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
26.32Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
26.32Single8K4NPubChem 1687197658K4N-GPR34-PubChem 168719765-Gi1/β1/γ2
26.32Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
26.32Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
26.32Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
26.32Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
26.32Single8ZPMAMD0708ZPM-CXCR4-AMD070
26.32Single9ODJMitragynine Pseudoindoxyl9ODJ-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
26.09Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
26.09Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
26.09Single6IBLArformoterol6IBL-β1-Arformoterol
26.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
26.09Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
26.09Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.09Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
26.09Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
26.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.09Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
26.09Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
26.09Single8E0GBU728E0G-μ-BU72
26.09Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
26.09Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
26.09Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
26.09Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
26.09Single8XBES3E-Lysophosphatidylserine 8XBE-GPR34-S3E-Lysophosphatidylserine-Gi1/β1/γ1
26.09Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.09Single8XVUCXCL28XVU-CXCR2-CXCL2
26.09Single8XWFCXCL38XWF-CXCR2-CXCL3
26.09Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
26.09Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
26.09Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
26.09Single9J0BUDP-Glucose9J0B-P2Y14-UDP-Glucose-Gi1/β1/γ2
26.09Single9KUGEP679KUG-C5a1-EP67-Go/β1/γ2
26.09Single9M54Neuropeptide-VF9M54-NPFF2-Neuropeptide-VF-Gi1/β1/γ2
26.09Single9UYHChemerin-99UYH-CML2-Chemerin-9-Arrestin2
26.09Single9VI9RFRP-39VI9-NPFF1-RFRP-3-Gi1/β1/γ2
26.09Single9YDPDADLE9YDP-δ-DADLE-chim(NtGi1L-Gs-CtGi1)/β1/γ2
26.09Single9YDRDADLE9YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
26.09Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.09Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.09Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
26.09Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
26.09Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
25.93Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.93Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
25.93Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
25.93Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
25.93Single8WSTMCH8WST-MCH2-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
25.93Consensusapelin_onOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
25.93Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
25.93Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
25.93Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.93Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
25.93Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
25.81Single8ZJETAK4488ZJE-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ1
25.81Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
25.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
25.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
25.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
25.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
25.00Single5WF6UK-4320975WF6-A2A-UK-432097
25.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
25.00Single6KNMJN241-96KNM-Apelin-JN241-9
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
25.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
25.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
25.00Single7JOZPubChem 752020227JOZ-D1-PubChem 75202022-Gs/β1/γ2
25.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
25.00Single7LJCSKF812977LJC-D1-SKF81297-Mevidalen-Gs/β1/γ2
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7RKNCX3CL17RKN-US28-CX3CL1-Gi1/β1/γ2
25.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
25.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
25.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
25.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
25.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
25.00Single7VGZRamelteon7VGZ-MT1-Ramelteon-Gi1/β1/γ2
25.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7Y64C5a7Y64-C5a1-C5a-Gi1/β1/γ2
25.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
25.00Single8IC0CXCL88IC0-CXCR1-CXCL8-Gi1/β1/γ2
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
25.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
25.00Single8IWM2-Phenylethylamine8IWM-TAA9-2-Phenylethylamine
25.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
25.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
25.00Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
25.00Single8QJ2pN1628QJ2-MC4-pN162-Gs/β1/γ2
25.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
25.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
25.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
25.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
25.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.00Single8XBGS3E-Lysophosphatidylserine 8XBG-GPR34-S3E-Lysophosphatidylserine
25.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
25.00Single8XQJJN2418XQJ-Apelin; Apelin-JN241
25.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
25.00Single8XZFWN5618XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
25.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
25.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8ZRTEndothelin-18ZRT-ETB-Endothelin-1
25.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
25.00Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
25.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
25.00Single9KZ8EP679KZ8-C3aB-EP67-Go/β1/γ2
25.00Single9METGp120; CD49MET-CXCR4-Gp120; CD4
25.00Single9NS9TUG-13759NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
25.00Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
25.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
25.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
25.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
25.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
25.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
25.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
25.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
25.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
25.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.00Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
25.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
25.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
25.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
24.00Single4AMJCarvedilol4AMJ-β1-Carvedilol
24.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
24.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
24.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.00Single7F8XNN90567F8X-CCKA-NN9056
24.00Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
24.00Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
24.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
24.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
24.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
24.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
24.00Single8XWNCXCL88XWN-CXCR2-CXCL8
24.00Single8ZJDKisspeptin-18ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
24.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
24.00Single9M4TSilodosin9M4T-Alpha1A-Silodosin
24.00Single9UYLChemerin-99UYL-CML2-Chemerin-9-Arrestin2
24.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
24.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
24.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
24.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
24.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
23.81Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
23.81Single5N2SPSB365N2S-A1-PSB36
23.81Single5WIUNemonapride5WIU-D4-Nemonapride
23.81Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.81Single5X7DCarazolol5X7D-β2-Carazolol-PubChem 129318963
23.81Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
23.81Single6HLPNetupitant6HLP-NK1-Netupitant
23.81Single6LFMCXCL86LFM-CXCR2-CXCL8-Gi1/β1/γ2
23.81Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
23.81Single7C61Ergotamine7C61-5-HT1B-Ergotamine
23.81Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Single7VFXfMIFL7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
23.81Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.81Single7WC6LSD7WC6-5-HT2A-LSD
23.81Single7WIGL-0542647WIG-SST2-L-054264-Gi1/β1/γ2
23.81Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
23.81Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.81Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
23.81Single8IZ4Lysophosphatidylserine (TJR)8IZ4-GPR34-Lysophosphatidylserine (TJR)-Gi1/β1/γ2
23.81Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
23.81Single8QOTNanobody-E8QOT-μ-Nanobody-E
23.81Single8S4DCMF-0198S4D-Apelin-CMF-019
23.81Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
23.81Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
23.81Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
23.81Single9IYBPGD29IYB-DP2-PGD2-A1D5Q-Gi1/β1/γ2
23.81Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
23.81Single9VJFBuspirone9VJF-5-HT1A-Buspirone-Gi3/β1/γ2
23.81Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
23.81Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
23.81Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
23.81Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
23.81Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
23.81Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
23.81Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.81Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.81Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.81Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
23.81Consensustrace-amine_onOrthosteric Ligandta1_on
23.53Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.53Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.53Single6ME5Agomelatine6ME5-MT1-Agomelatine
23.53Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
23.53Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
23.53Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.53Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
23.53Single8IW72-Phenylethylamine8IW7-TAA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.53Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
23.53Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
23.53Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
23.53Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
23.53Single9LRCHistamine9LRC-H4-Histamine
23.53Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
23.53Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.53Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.08Single6HLOAprepitant6HLO-NK1-Aprepitant
23.08Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.08Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
23.08Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
23.08Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
23.08Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
23.08Single8Z7JJN241-98Z7J-Apelin-JN241-9-Gi1/β1/γ2
23.08Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
23.08Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
23.08Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
23.08Single9JFK(Pen5)-Urotensin II9JFK-UT-(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single9KT7MK68929KT7-HCA2-MK6892-Gi1/β1/γ2
23.08Single9KV6TLQP219KV6-C3aB-TLQP21-Go/β1/γ2
23.08Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
23.08Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
23.08Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
23.08Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
23.08Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
22.73Single2YDVNECA2YDV-A2A-NECA
22.73Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.73Single4UHRCGS216804UHR-A2A-CGS21680
22.73Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
22.73Single5G53NECA5G53-A2A-NECA-Gs
22.73Single5TZRMK86665TZR-FFA1-MK8666
22.73Single5V54Methiothepin5V54-5-HT1B-Methiothepin
22.73Single6E59L-7607356E59-NK1-L-760735
22.73Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
22.73Single6J20Aprepitant6J20-NK1-Aprepitant
22.73Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
22.73Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.73Single7B6WCyclazosin7B6W-α1b-Cyclazosin
22.73Single7R0CAVP7R0C-V2-AVP-Arrestin2
22.73Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
22.73Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
22.73Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
22.73Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
22.73Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
22.73Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
22.73Single8HPTC5a (C-terminal peptide)8HPT-C5a1-C5a (C-terminal peptide)-Go/β1/γ2
22.73Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
22.73Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
22.73Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
22.73Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
22.73Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.73Single8JZPC5a8JZP-C5a1-C5a-Go/β1/γ2
22.73Single8WU1MDMB-Fubinaca8WU1-CB1-MDMB-Fubinaca-Arrestin2
22.73Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
22.73Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
22.73Single9BJKNaloxone9BJK-μ-Naloxone-PubChem 171642066
22.73Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
22.73Single9JCLADP9JCL-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
22.73Single9MENGp120 (V3 loop)9MEN-CXCR4-Gp120 (V3 loop)
22.73Single9YDVMRS29059YDV-P2Y14-MRS2905-Gi1/β1/γ2
22.73Consensus5ht1_offOrthosteric Ligand5ht1b_off
22.73Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
22.73Consensusa2_onOrthosteric Liganda2b_on
22.73Consensusa2_on_gpOrthosteric Liganda2b_on_gp
22.73Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.73Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.73Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
22.73Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
22.73Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
22.73Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
22.73Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
22.73Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.73Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.73Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
22.73Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
22.73Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.73Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.73Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
22.73Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
22.73Consensustachykinin_offOrthosteric Ligandnk1_off
22.73Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
22.58Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
22.58Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
22.58Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.58Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
22.58Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
22.22Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
22.22Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
22.22Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.22Single6MEOGp160; CD46MEO-CCR5-Gp160; CD4
22.22Single6W25SHU91196W25-MC4-SHU9119-Ca
22.22Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.22Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
22.22Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
22.22Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
22.22Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
22.22Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
22.22Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
22.22Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.22Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
22.22Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
22.22Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
22.22Single8K6NNeuropeptide-Y8K6N-Y2-Neuropeptide-Y-Gi2/β1/γ1
22.22Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
22.22Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
22.22Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
22.22Single8XZHMM078XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
22.22Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
22.22Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
22.22Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
22.22Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
22.22Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
22.22Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
22.22Single9JEDHistamine9JED-H4-Histamine-PO4-Gi1/β1/γ2
22.22Single9JEQHistamine9JEQ-H3-Histamine-Gi1/β1/γ2
22.22Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
22.22Single9L42Histamine9L42-H4-Histamine-Gi1/β1/γ2
22.22Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
22.22Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single9U9VMETH9U9V-β2-METH-Gs/β1/γ2
22.22Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
22.22Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
22.22Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
22.22Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
22.22Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
22.22Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
22.22Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.22Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusgq_nucleotideOrthosteric Ligandgq_p2y
22.22Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.22Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
22.22Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.22Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.22Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.88Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
21.88Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
21.88Consensusbombesin_onOrthosteric Ligandbb2_on
21.88Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
21.88Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.88Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
21.74Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.74Single4AMIBucindolol4AMI-β1-Bucindolol
21.74Single4N4WSANT-14N4W-SMO-SANT-1
21.74Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
21.74Single4PY02MeSATP4PY0-P2Y12-2MeSATP
21.74Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
21.74Single6A93Risperidone6A93-5-HT2A-Risperidone
21.74Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
21.74Single6MXTSalmeterol6MXT-β2-Salmeterol
21.74Single6OS2TRV0266OS2-AT1-TRV026
21.74Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
21.74Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.74Single6ZG4HTL00099366ZG4-M1-HTL0009936
21.74Single7DFPSpiperone7DFP-D2-Spiperone
21.74Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
21.74Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.74Single7W0LPubChem 1227019087W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
21.74Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
21.74Single7YITNalfurafine7YIT-κ-Nalfurafine
21.74Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
21.74Single8HK2C3a8HK2-C3aB-C3a-Gi1/β1/γ2
21.74Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
21.74Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
21.74Single8JJLOlodaterol8JJL-β2-Olodaterol
21.74Single8JWZEtrumadenant8JWZ-A2A-Etrumadenant-Na
21.74Single8U26Substance-P8U26-NK1-Substance-P-Gs/β1/γ2
21.74Single8XQJJN2418XQJ-Apelin; Apelin-JN241
21.74Single8XYIVUF106618XYI-CXCR3-VUF10661
21.74Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
21.74Single9KVG5-MeO-DMT9KVG-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
21.74Single9V6ONalfurafine9V6O-κ-Nalfurafine-Gi1/β1/γ2
21.74Single9VJ6F-155999VJ6-5-HT1A-F-15599-Gi3/β1/γ2
21.74Single9WSVDAMGO9WSV-μ-DAMGO-Arrestin2
21.74Single9WSWEndomorphin9WSW-μ-Endomorphin-chim(NtGi1-Gz)/β1/γ2
21.74Consensusalpha1_offOrthosteric Ligandalpha1a_off
21.74Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
21.74Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
21.74Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
21.74Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
21.74Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
21.74Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
21.74Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.74Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.74Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
21.74Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
21.74Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
21.74Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
21.74Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
21.74Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
21.74Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusorexin_onOrthosteric Ligandox2_on
21.43Single6METGp160; CD46MET-CCR5-Gp160; CD4
21.43Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
21.43Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
21.43Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
21.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
21.43Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
21.43Single8XZJWN3538XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
21.43Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
21.43Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.43Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
21.43Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Consensusvasop-oxy_onOrthosteric Ligandv2_on
21.43Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
21.21Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
21.21Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.05Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
21.05Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
21.05Single5OLVLUAA470705OLV-A2A-LUAA47070-Na
21.05Single5ZKQABT-4915ZKQ-PAF-ABT-491
21.05Single6AKXA4R6AKX-CCR5-A4R
21.05Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.05Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
21.05Single7EJ0Norepinephrine7EJ0-α2a-Norepinephrine-Go/β1/γ2
21.05Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
21.05Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
21.05Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
21.05Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
21.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
21.05Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
21.05Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.05Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
21.05Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
21.05Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
21.05Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
21.05Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
21.05Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
21.05Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.05Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
21.05Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
21.05Single8IW4Spermidine8IW4-TAA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
21.05Single8IWESpermidine8IWE-TAA9-Spermidine
21.05Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
21.05Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
21.05Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
21.05Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
21.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8TZQDopamine8TZQ-D2-Dopamine-Go/β1/γ2
21.05Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
21.05Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
21.05Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
21.05Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
21.05Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
21.05Single9H2XPubChem 1756706449H2X-A2A-PubChem 175670644-Na
21.05Single9JKXAcifran9JKX-HCA3-Acifran-Gi1/β1/γ2
21.05Single9KVHCinobufotenine9KVH-5-HT1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
21.05Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
21.05Single9W49U-50488H9W49-κ-U-50488H-Gi1/β1/γ2
21.05Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.05Consensusalpha2_offOrthosteric Ligandalpha2c_off
21.05Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.05Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
21.05Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
21.05Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
21.05Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.05Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.05Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
20.83Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.83Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.83Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
20.83Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.83Single6H7LDobutamine6H7L-β1-Dobutamine
20.83Single6UP7Neurotensin-(8-13)6UP7-NTS1-Neurotensin-(8-13)-Arrestin2
20.83Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.83Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
20.83Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
20.83Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.83Single7Y65C5a (C-terminal peptide)7Y65-C5a1-C5a (C-terminal peptide)-Gi1/β1/γ2
20.83Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
20.83Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.83Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.83Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single9HYIDP819HYI-5-HT1A-DP81-Gi1/β1/γ2
20.83Single9KT8Acifran9KT8-HCA2-Acifran-Gi1/β1/γ2
20.83Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.83Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.83Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.83Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.83Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.83Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
20.83Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.83Consensusendothelin_offOrthosteric Ligandetb_off
20.83Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
20.83Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
20.83Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
20.69Single7F9YGhrelin7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7P02Substance-P7P02-NK1-Substance-P-chim(NtGi1-Gs)/β1/γ2
20.69Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
20.69Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
20.69Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8HK5C5a8HK5-C5a1-C5a-Gi1/β1/γ2
20.69Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single4LDOEpinephrine4LDO-β2-Epinephrine
20.00Single4UG2CGS216804UG2-A2A-CGS21680
20.00Single4XT3CX3CL14XT3-US28-CX3CL1
20.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
20.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
20.00Single5UVIZM-2413855UVI-A2A-ZM-241385
20.00Single5VBLAMG3054 5VBL-Apelin-AMG3054
20.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.00Single6IQLL7458706IQL-D4-L745870
20.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
20.00Single6KUXRS799486KUX-α2a-RS79948
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
20.00Single6PS0Carazolol6PS0-β2-Carazolol
20.00Single6PS4ICI118-5516PS4-β2-ICI118-551
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
20.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
20.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
20.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
20.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
20.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
20.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7RKFCX3CL17RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
20.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7SK9CCX6627SK9-ACKR3-CCX662
20.00Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
20.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
20.00Single7UL3Famotidine7UL3-H2-Famotidine
20.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Single7VV6C48/807VV6-MRGPRX2-C48/80
20.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
20.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE5Constrained Epinephrine8GE5-β2-Constrained Epinephrine-Gs/β1/γ1
20.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
20.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
20.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
20.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
20.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
20.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
20.00Single8JIMMonomethyl fumarate8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.00Single8PM2DMCHA8PM2-TA7-DMCHA-Gs/β1/γ2
20.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
20.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
20.00Single8THKA-616038THK-Alpha1A-A-61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8U02Dopamine8U02-D2-Dopamine-Go/β1/γ2
20.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
20.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
20.00Single8X5YAstemizole8X5Y-H1-Astemizole
20.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
20.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
20.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100
20.00Single9ARXSerotonin9ARX-5-HT2A-Serotonin
20.00Single9AS3LSD9AS3-5-HT2A-LSD
20.00Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AS5Mescaline9AS5-5-HT2A-Mescaline
20.00Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
20.00Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
20.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
20.00Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
20.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
20.00Single9K1DButyric acid9K1D-FFA2-Butyric acid-Gi1/β1/γ2
20.00Single9KUWCMPD6449KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
20.00Single9KVIBufotenin9KVI-5-HT1A-Bufotenin-PtdIns4P-Gi1/β1/γ2
20.00Single9KZ2EP679KZ2-C3aB-EP67-Go/β1/γ2
20.00Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
20.00Single9MD1Buspirone9MD1-5-HT1A-Buspirone-PtdIns4P-Gz/β1/γ2
20.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
20.00Single9ODLMitragynine Pseudoindoxyl9ODL-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
20.00Single9PXVNaloxone9PXV-μ-Naloxone-Gi1/β1/γ2
20.00Single9VJG8-OH-DPAT9VJG-5-HT1A-8-OH-DPAT-chim(NtGi2-Gz)/β1/γ2
20.00Single9VNFPindolol9VNF-5-HT1A-Pindolol-Go/β1/γ2
20.00Single9W33S5A19W33-SST5-S5A1
20.00Single9W6W5-CT9W6W-5-HT5A-5-CT-Gi1/β1/γ2
20.00Single9WSXEndomorphin9WSX-μ-Endomorphin-Arrestin2
20.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
20.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
20.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
20.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
20.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
20.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.00Consensushca_onOrthosteric Ligandhca2_on
20.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
20.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Consensussensory_offOrthosteric Ligandopsins_off
19.35Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
19.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
19.35Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
19.35Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
19.35Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
19.35Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
19.23Single4XT1CX3CL14XT1-US28-CX3CL1
19.23Single7L0RNeurotensin-(8-13)7L0R-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
19.23Single7NA7Ghrelin7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2
19.23Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.23Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
19.23Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
19.23Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
19.23Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
19.23Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
19.23Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
19.23Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
19.23Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.23Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
19.23Single8WKYPG-9348WKY-MC4-PG-934
19.23Single8XBHPubChem 1626566368XBH-GPR34-PubChem 162656636-Gi1/β1/γ2
19.23Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.23Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.23Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
19.23Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
19.23Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single2Y04Salbutamol2Y04-β1-Salbutamol
19.05Single3EMLZM-2413853EML-A2A-ZM-241385
19.05Single3NY8ICI118-5513NY8-β2-ICI118-551
19.05Single3NYAAlprenolol3NYA-β2-Alprenolol
19.05Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
19.05Single4GBRCarazolol4GBR-β2-Carazolol
19.05Single4QIMANTA XV4QIM-SMO-ANTA XV
19.05Single4U16N-methyl-Scopolamine4U16-M3-N-methyl-Scopolamine
19.05Single5DHGC-355DHG-NOP-C-35
19.05Single5DHHSB-6121115DHH-NOP-SB-612111
19.05Single5DSGTiotropium5DSG-M4-Tiotropium
19.05Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
19.05Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
19.05Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
19.05Single5UIGPubChem 1240811965UIG-A2A-PubChem 124081196
19.05Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
19.05Single5YC8N-methyl-Scopolamine5YC8-M2-N-methyl-Scopolamine
19.05Single5ZK8N-methyl-Scopolamine5ZK8-M2-N-methyl-Scopolamine
19.05Single5ZKCN-methyl-Scopolamine5ZKC-M2-N-methyl-Scopolamine
19.05Single5ZKPSR274175ZKP-PAF-SR27417
19.05Single6D27CAY104716D27-DP2-CAY10471
19.05Single6DRXLisuride6DRX-5-HT2B-Lisuride
19.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
19.05Single6H7MSalbutamol6H7M-β1-Salbutamol
19.05Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.05Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
19.05Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
19.05Single6PS1Timolol6PS1-β2-Timolol
19.05Single6S0LZM-2413856S0L-A2A-ZM-241385
19.05Single6TOTLemborexant6TOT-OX1-Lemborexant
19.05Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.05Single7BTSEpinephrine7BTS-β1-Epinephrine
19.05Single7BU6Norepinephrine7BU6-β1-Norepinephrine
19.05Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
19.05Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.05Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
19.05Single7NA8Ibutamoren7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
19.05Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
19.05Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
19.05Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
19.05Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
19.05Single8CU6LJ-45178CU6-A2A-LJ-4517
19.05Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
19.05Single8EFQDAMGO8EFQ-μ-DAMGO-Gi1/β1/γ2
19.05Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
19.05Single8GE2Constrained Epinephrine8GE2-β2-Constrained Epinephrine-Gs/β1/γ1
19.05Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
19.05Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
19.05Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
19.05Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
19.05Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
19.05Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
19.05Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.05Single8J6PNiacin8J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
19.05Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
19.05Single8JHNMonomethyl fumarate8JHN-HCA2-Monomethyl fumarate-Go/β1/γ2
19.05Single8JIINiacin8JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
19.05Single8JJOAlprenolol8JJO-β2-Alprenolol
19.05Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
19.05Single8JXRLSD8JXR-D1-LSD
19.05Single8K5DGSK2560738K5D-HCA2-GSK256073
19.05Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
19.05Single8T1WCVN4248T1W-GPR6-CVN424
19.05Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
19.05Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
19.05Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
19.05Single8X64Desloratadine8X64-H1-Desloratadine
19.05Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
19.05Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
19.05Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
19.05Single9CHXCarazolol9CHX-β2-Carazolol
19.05Single9DYFAsenapine9DYF-5-HT1A-Asenapine-PtdIns4P-Gi1/β1/γ2
19.05Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
19.05Single9H37PubChem 1756706469H37-A2A-PubChem 175670646-Na
19.05Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
19.05Single9JEAAtropine9JEA-M1-Atropine
19.05Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
19.05Single9KFTfMLFC9KFT-FPR1-ALX-fMLFC-Gi1/β1/γ2
19.05Single9KUXCMPD6449KUX-Apelin; Apelin-CMPD644-Arrestin2
19.05Single9P1SZM-2413859P1S-A2A-ZM-241385
19.05Single9PLNPubChem 1682595949PLN-α2a-PubChem 168259594
19.05Single9PLOPubChem 1682595949PLO-α2a-PubChem 168259594-Go/β1/γ2
19.05Single9PQDPubChem 1764919279PQD-α2a-PubChem 176491927
19.05Single9PXWNaloxone9PXW-μ-Naloxone-GDPβS-Gi1/β1/γ2
19.05Single9UAZAtropine9UAZ-M1-Atropine
19.05Single9VMYTMU41429VMY-5-HT1A-TMU4142-Go/β1/γ2
19.05Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.05Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.05Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.05Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.05Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.05Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.05Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
19.05Consensusalpha2_onOrthosteric Ligandalpha2b_on
19.05Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
19.05Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.05Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.05Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
19.05Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
19.05Consensusdopamine_offOrthosteric Ligandd2_off d3_off
19.05Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
19.05Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
19.05Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.05Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
19.05Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
19.05Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
19.05Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
19.05Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.05Consensushca_on_gpOrthosteric Ligandhca2_on_gp
19.05Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
19.05Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
19.05Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
18.75Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
18.75Single7WC4Serotonin7WC4-5-HT2A-Serotonin
18.75Single8KGGLysophosphatidylserine (WJS)8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
18.75Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.75Single9JIDNiacin9JID-HCA3-Niacin-Gi1/β1/γ2
18.52Single7PIVAfamelanotide7PIV-MC4-Afamelanotide-Gs/β1/γ2
18.52Single7XNACYN1548067XNA-SST2-CYN154806
18.52Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
18.52Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single9E82CXCL12 (fragment)9E82-ACKR3-CXCL12 (fragment)-Arrestin2
18.52Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.52Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
18.52Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
18.52Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.52Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
18.18Single2RH1Carazolol2RH1-β2-Carazolol
18.18Single2Y00Dobutamine2Y00-β1-Dobutamine
18.18Single2Y03Isoprenaline2Y03-β1-Isoprenaline
18.18Single2YCWCarazolol2YCW-β1-Carazolol
18.18Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.18Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
18.18Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
18.18Single5C1MBU725C1M-μ-BU72
18.18Single5D6LCarazolol5D6L-β2-Carazolol
18.18Single5GLHEndothelin-15GLH-ETB-Endothelin-1
18.18Single5IUAQ274563485IUA-A2A-Q27456348-Na
18.18Single5JQHCarazolol5JQH-β2-Carazolol
18.18Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.18Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
18.18Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.18Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.18Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.18Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
18.18Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
18.18Single6LUQHaloperidol6LUQ-D2-Haloperidol
18.18Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.18Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
18.18Single6PS3Carvedilol6PS3-β2-Carvedilol
18.18Single6PS6Timolol6PS6-β2-Timolol
18.18Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
18.18Single6S0QZM-2413856S0Q-A2A-ZM-241385
18.18Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
18.18Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
18.18Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
18.18Single7BVQCarazolol7BVQ-β1-Carazolol
18.18Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
18.18Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
18.18Single7EPFNAM5977EPF-mGlu2-NAM597
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
18.18Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.18Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.18Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.18Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
18.18Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
18.18Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.18Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
18.18Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
18.18Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
18.18Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
18.18Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
18.18Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.18Single8JXSPF-61428JXS-D1-PF-6142
18.18Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.18Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
18.18Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
18.18Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
18.18Single8ZMFPubChem 1719206738ZMF-5-HT2C-PubChem 171920673
18.18Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
18.18Single8ZYTNeurotensin-(8-13)8ZYT-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
18.18Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
18.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
18.18Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9DYDAsenapine9DYD-5-HT1A-Asenapine-PtdIns4P-Go/β1/γ2
18.18Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
18.18Single9EHSLUF76029EHS-A3A-LUF7602
18.18Single9EKHONO-30302979EKH-DP1-ONO-3030297
18.18Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
18.18Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
18.18Single9HAPTolvaptan9HAP-V2-Tolvaptan
18.18Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
18.18Single9JKSPubChem 442501769JKS-HCA3-PubChem 44250176-Gi1/β1/γ2
18.18Single9KT6Acifran9KT6-HCA3-Acifran-Gi1/β1/γ2
18.18Single9L74S1P d16:19L74-S1P3-S1P d16:1-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single9PXYNaloxone9PXY-μ-Naloxone-GDPβS-Gi1/β1/γ2
18.18Single9U81Tolvaptan9U81-V2-Tolvaptan
18.18Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
18.18Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
18.18Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
18.18Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
18.18Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.18Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.18Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
18.18Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
18.18Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
18.18Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
18.18Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
18.18Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
18.18Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
18.18Consensusamine_offonOrthosteric Ligandamine_off amine_on
18.18Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
18.18Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
18.18Consensusbeta2_offOrthosteric Ligand2RH1-β2-Carazolol 6PS3-β2-Carvedilol 6PS5-β2-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-PubChem 913103 6PRZ-β2-Alprenolol
18.18Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
18.18Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
18.18Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
18.18Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
18.18Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.18Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
18.18Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
18.18Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusm2_offOrthosteric Ligand5ZKC-M2-N-methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
18.18Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
17.86Single9B54VIP369B54-CB1-VIP36-Gi1/β1/γ2
17.86Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.86Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
17.65Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
17.65Single9CHUNorepinephrine9CHU-β2-Norepinephrine
17.65Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
17.65Single9M42A1L8O9M42-GPR139-A1L8O-chim(Gs-CtGq)/β1/γ2
17.65Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.65Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.65Consensusp2y_offOrthosteric Ligandp2y1_off
17.39Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
17.39Single4LDLHydroxybenzyl Isoproterenol4LDL-β2-Hydroxybenzyl Isoproterenol
17.39Single4U15Tiotropium4U15-M3-Tiotropium
17.39Single5D5ACarazolol5D5A-β2-Carazolol
17.39Single5D5BCarazolol5D5B-β2-Carazolol
17.39Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.39Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
17.39Single6DDEDAMGO6DDE-μ-DAMGO-Gi1/β1/γ2
17.39Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.39Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.39Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
17.39Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
17.39Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.39Single6OL9Tiotropium6OL9-M5-Tiotropium
17.39Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.39Single6TQ7SB-3348676TQ7-OX1-SB-334867
17.39Single6WGTLSD6WGT-5-HT2A-LSD
17.39Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
17.39Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
17.39Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
17.39Single7F1TCCL37F1T-CCR5-CCL3
17.39Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
17.39Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
17.39Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
17.39Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
17.39Single7M8W15r-Methyl-PGD27M8W-DP2-15r-Methyl-PGD2-Na
17.39Single7PX4PSB-21137PX4-A2A-PSB-2113
17.39Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.39Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
17.39Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
17.39Single7U2LC5-guano7U2L-μ-C5-guano-Gi1/β1/γ2
17.39Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
17.39Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
17.39Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
17.39Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.39Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7XOWSulfated Gastrin-(10-17)7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
17.39Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
17.39Single8EA0Iperoxo8EA0-M3-Iperoxo
17.39Single8FMZNeurotensin-(8-13)8FMZ-NTS1-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.39Single8HQCC5a8HQC-C5a1-C5a-Go/β1/γ2
17.39Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
17.39Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
17.39Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.39Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
17.39Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
17.39Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
17.39Single8XBIPubChem 1626566368XBI-GPR34-PubChem 162656636
17.39Single8XVLZibotentan8XVL-ETA-Zibotentan
17.39Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
17.39Single9AS9RS130-1809AS9-5-HT2A-RS130-180
17.39Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single9B65MDMB-Fubinaca9B65-CB1-MDMB-Fubinaca-Gi1/β1/γ2
17.39Single9BS9LSD9BS9-D2-LSD
17.39Single9BSBLSD9BSB-D2-LSD-chim(NtGi1-Go)/β1/γ2
17.39Single9E9SPGD29E9S-DP1-PGD2-Gs/β1/γ1
17.39Single9I54PubChem 1764520919I54-D1-PubChem 176452091-Gs/β1/γ2
17.39Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
17.39Single9KVPSB2901579KVP-C3aB-SB290157-Go/β1/γ2
17.39Single9PY3Loperamide9PY3-μ-Loperamide-GDPβS-Gi1/β1/γ2
17.39Single9PY4Loperamide9PY4-μ-Loperamide-GDPβS-Gi1/β1/γ2
17.39Single9RHGC4079RHG-FZD7-C407
17.39Single9UCPIperoxo9UCP-M1-Iperoxo-G11(CT)
17.39Single9WSTDAMGO9WST-μ-DAMGO-chim(NtGi1-Gz)/β1/γ2
17.39Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
17.39Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
17.39Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-PubChem 594590-Na 3ZPR-β1-PubChem 598754-Na
17.39Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
17.39Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
17.39Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.39Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.39Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.39Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.39Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.39Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.39Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
17.39Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.24Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
17.24Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
17.24Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
17.14Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
17.14Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
16.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
16.67Single3D4STimolol3D4S-β2-Timolol
16.67Single3OE6IT1t3OE6-CXCR4-IT1t
16.67Single3UZAGTPL92363UZA-A2A-GTPL9236
16.67Single4LDEBI1671074LDE-β2-BI167107
16.67Single4PXFOctyl-Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
16.67Single4XNWMRS25004XNW-P2Y1-MRS2500
16.67Single5CXVTiotropium5CXV-M1-Tiotropium
16.67Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
16.67Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
16.67Single6CM4Risperidone6CM4-D2-Risperidone
16.67Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
16.67Single6H7NXamoterol6H7N-β1-Xamoterol
16.67Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
16.67Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
16.67Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
16.67Single7L0SNeurotensin-(8-13)7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
16.67Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
16.67Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
16.67Single7XV3Lysophosphatidylserine (WJS)7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8DWCBAM8-228DWC-MRGPRX1-BAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
16.67Single8FYTLSD8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1
16.67Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
16.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8ITFDMCHA8ITF-TAA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
16.67Single8IU2All-trans-Retinal8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
16.67Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
16.67Single8JEFPubChem 113671668JEF-HCA3-PubChem 11367166-Gi1/β1/γ2
16.67Single8JJ8Arformoterol8JJ8-β2-Arformoterol
16.67Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
16.67Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
16.67Single8WRBLysophosphatidylserine (UBL)8WRB-GPR34-Lysophosphatidylserine (UBL)-Gi1/β1/γ2
16.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
16.67Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.67Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
16.67Single9DGIZ85267113509DGI-CB1-Z8526711350
16.67Single9EK0Iperoxo9EK0-M5-Iperoxo-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9IJRC179IJR-GPR52-C17-Arrestin2
16.67Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
16.67Single9JFYNeuropeptide-SF9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
16.67Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
16.67Single9JKT(2R)-2-hydroxy-3-phenylpropanoic acid9JKT-HCA3-(2R)-2-hydroxy-3-phenylpropanoic acid-Gi1/β1/γ2
16.67Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
16.67Single9M8POleic monoethanolamide9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
16.67Single9VIFNeuropeptide-VF9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
16.67Single9W32SSTR5 antagonist 19W32-SST5-SSTR5 antagonist 1
16.67Single9YDUUDP-Glucose9YDU-P2Y14-UDP-Glucose-Gi1/β1/γ2
16.67Consensus5ht2_onOrthosteric Ligand5ht2b_on
16.67Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
16.67Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.67Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
16.67Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
16.67Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
16.67Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Consensusgi_sensoryOrthosteric Ligandgi_opsins
16.67Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
16.67Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
16.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.67Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
16.67Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
16.67Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
16.67Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
16.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
16.67Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
16.67Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
16.67Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
16.67Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
16.13Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.13Single7SK3CXCL127SK3-ACKR3-CXCL12
16.13Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.13Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
16.13Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.13Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
16.13Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
16.00Single5X93K-87945X93-ETB-K-8794
16.00Single6DDFDAMGO6DDF-μ-DAMGO-Gi1/β1/γ2
16.00Single7D7MPGE27D7M-EP4-PGE2-Gs/β1/γ1
16.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
16.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
16.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
16.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
16.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
16.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
16.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
16.00Single8GAGZ85267113508GAG-CB1-Z8526711350-Gi1/β1/γ2
16.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.00Single8JPFNeurotensin-(8-13)8JPF-NTS1-Neurotensin-(8-13)-SBI-553
16.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.00Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
16.00Single8XGSKisspeptin-18XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
16.00Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
16.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.00Single9DYEBuspirone9DYE-5-HT1A-Buspirone-PtdIns4P-Go/β1/γ2
16.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
16.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.00Single9IZFLPA9IZF-LPA1-LPA-Gi1/β1/γ2
16.00Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9KV8TLQP219KV8-C3aB-TLQP21-Go/β1/γ2
16.00Single9KWXC5a-des-Arg9KWX-C5a1-C5a-des-Arg-Go/β1/γ2
16.00Single9L79AR2314539L79-GPR119-AR231453-chim(NtGi1-Gs)/β1/γ2
16.00Single9M1HPGE29M1H-EP1-PGE2-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9WP9S1P9WP9-S1P3-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
16.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
16.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
16.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
16.00Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
15.79Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
15.79Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
15.79Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
15.79Single3OE9IT1t3OE9-CXCR4-IT1t
15.79Single3PBLEticlopride3PBL-D3-Eticlopride
15.79Single5L7IVismodegib5L7I-SMO-Vismodegib
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.79Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.79Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2
15.79Single7SRQLSD7SRQ-5-HT2B-LSD
15.79Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
15.79Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
15.79Single7XKFDehydroepiandrosterone7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
15.79Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
15.79Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
15.79Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
15.79Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
15.79Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
15.79Single8K5BNiacin8K5B-HCA2-Niacin
15.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
15.79Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.79Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
15.79Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
15.79Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
15.79Single8ZYUNeurotensin-(8-13)8ZYU-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
15.79Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9AS7Psilocin9AS7-5-HT2A-Psilocin
15.79Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
15.79Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
15.79Single9KUWCMPD6449KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
15.79Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
15.79Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.62Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
15.38Single5ZTYAM102575ZTY-CB2-AM10257
15.38Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
15.38Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.38Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
15.38Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8SAILysophosphatidylserine (S12)8SAI-GPR34-Lysophosphatidylserine (S12)-Gi1/β1/γ2
15.38Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
15.38Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
15.38Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
15.38Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9JF4PD1683689JF4-BB1-PD168368
15.38Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
15.38Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
15.38Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
15.15Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.00Single3ODUIT1t3ODU-CXCR4-IT1t
15.00Single3PWHZM-2413853PWH-A2A-ZM-241385
15.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
15.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.00Single6B73MP11046B73-κ-MP1104
15.00Single6DS0LY2660976DS0-5-HT2B-LY266097
15.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
15.00Single6LFOCXCL86LFO-CXCR2-CXCL8-Gi1/β1/γ2
15.00Single6OBAAlprenolol6OBA-β2-Alprenolol-GTPL11074
15.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
15.00Single6TODEMPA6TOD-OX1-EMPA-Na
15.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
15.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7T6STC-FPR 437T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2
15.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
15.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
15.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
15.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
15.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
15.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
15.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
15.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
15.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
15.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
15.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
15.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
15.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
15.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
15.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
15.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
15.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
15.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
15.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
15.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.00Single8YNFCXCL88YNF-ACKR1-CXCL8
15.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
15.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
15.00Single8Z87CHBA8Z87-HCA1-CHBA-Gi1/β1/γ2
15.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
15.00Single9KO2CCL199KO2-CCR7-CCL19-Gi1/β1
15.00Single9KO6CCL199KO6-CCR7-CCL19
15.00Single9LL9DOI9LL9-5-HT2A-DOI-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single9LLBDOI-NBOMe9LLB-5-HT2A-DOI-NBOMe-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
15.00Single9PEEPF-07054894; OXM29PEE-CCR6-PF-07054894; OXM2
15.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
15.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.00Consensusangiotensin_offOrthosteric Ligandat1_off
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
15.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
15.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
15.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
15.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
15.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
14.81Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
14.81Single8DWGBAM8-228DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
14.81Single8KIGSHU91198KIG-MC3-SHU9119-Ca
14.81Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
14.81Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
14.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
14.81Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
14.81Consensussomatostatin_offOrthosteric Ligandsst2_off
14.71Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
14.29Single3REYPubChem 56973REY-A2A-PubChem 5697
14.29Single3RZECidoxepin3RZE-H1-Cidoxepin
14.29Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
14.29Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
14.29Single4ZJCSB-6740424ZJC-OX1-SB-674042
14.29Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
14.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
14.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
14.29Single5JTBZM-2413855JTB-A2A-ZM-241385
14.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
14.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
14.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
14.29Single6A94Zotepine6A94-5-HT2A-Zotepine
14.29Single6AQFZM-2413856AQF-A2A-ZM-241385
14.29Single6FFIMPEP6FFI-mGlu5-MPEP
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
14.29Single6PS5Propranolol6PS5-β2-Propranolol
14.29Single6TPGEMPA6TPG-OX2-EMPA
14.29Single6TPKRetosiban6TPK-OT-Retosiban
14.29Single6TPNHTL66416TPN-OX2-HTL6641
14.29Single6VI4JDTic6VI4-κ-JDTic
14.29Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
14.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.29Single6ZG9GSK10347026ZG9-M1-GSK1034702
14.29Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
14.29Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
14.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
14.29Single7F1QCCL37F1Q-CCR5-CCL3-Gi1/β1/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single7T32ZM-2413857T32-A2A-ZM-241385
14.29Single7VBITirzepatide (non-acylated)7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
14.29Single7VODCariprazine7VOD-5-HT2A-Cariprazine
14.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
14.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
14.29Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
14.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
14.29Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
14.29Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
14.29Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
14.29Single8GURCP559408GUR-CB2-CP55940-Gi1/β1/γ2
14.29Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
14.29Single8K5CAcipimox8K5C-HCA2-Acipimox
14.29Single8K9KDAMGO8K9K-μ-DAMGO-Gi3/β1/γ1
14.29Single8K9LDAMGO8K9L-μ-DAMGO-BMS-986122-Gi3/β1/γ1
14.29Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
14.29Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
14.29Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
14.29Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
14.29Single8ZBWQuin-C18ZBW-FPR2-ALX-Quin-C1-Gi2/β1/γ2
14.29Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
14.29Single9AS8Psilocin9AS8-5-HT2A-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9JKYAcifran9JKY-HCA2-Acifran-Gi1/β1/γ2
14.29Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
14.29Single9KXSEP679KXS-C5a1-EP67-Go/β1/γ2
14.29Single9L84Epinephrine9L84-β1-Epinephrine-Atazanavir-Gs/β1/γ2
14.29Single9LL8Psilocin9LL8-5-HT2A-Psilocin-Gi1/β1/γ2
14.29Single9P1TZM-2413859P1T-A2A-ZM-241385
14.29Single9PXXNaloxone9PXX-μ-Naloxone-GDPβS-Gi1/β1/γ2
14.29Single9PY2Loperamide9PY2-μ-Loperamide-GDPβS-Gi1/β1/γ2
14.29Single9U80Conivaptan9U80-V2-Conivaptan
14.29Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA47070-Na 5N2R-A2A-PSB36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-Etrumadenant-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-PubChem 984073-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
14.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
14.29Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
14.29Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
14.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.29Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
14.29Consensusvasop-oxy_offOrthosteric Ligandot_off
13.89Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
13.89Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.79Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
13.79Single6VN7PACAP276VN7-VPAC1-PACAP27-Gs/β1/γ2
13.79Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
13.79Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
13.64Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
13.64Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
13.64Single2Y01Dobutamine2Y01-β1-Dobutamine
13.64Single2Y02Carmoterol2Y02-β1-Carmoterol
13.64Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.64Single3ZPQPubChem 5945903ZPQ-β1-PubChem 594590-Na
13.64Single3ZPRPubChem 5987543ZPR-β1-PubChem 598754-Na
13.64Single4DAJTiotropium4DAJ-M3-Tiotropium
13.64Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.64Single4MQSIperoxo4MQS-M2-Iperoxo
13.64Single4U14Tiotropium4U14-M3-Tiotropium
13.64Single4YAYZD-71554YAY-AT1-ZD-7155
13.64Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.64Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.64Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.64Single5TGZAM65385TGZ-CB1-AM6538
13.64Single5UENDU1725UEN-A1-DU172
13.64Single6FFHFenobam6FFH-mGlu5-Fenobam
13.64Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.64Single6KPFAM120336KPF-CB2-AM12033-Gi1/β1/γ2
13.64Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
13.64Single6PRZAlprenolol6PRZ-β2-Alprenolol
13.64Single6PS2Alprenolol6PS2-β2-Alprenolol
13.64Single7BU7BI1671077BU7-β1-BI167107
13.64Single7PYRPSB-21157PYR-A2A-PSB-2115
13.64Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
13.64Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
13.64Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
13.64Single7UL4Alvimopan7UL4-μ-Alvimopan
13.64Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.64Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
13.64Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
13.64Single7VIFFTY720-P7VIF-S1P1-FTY720-P-Gi1/β1/γ2
13.64Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
13.64Single7WC7Lisuride7WC7-5-HT2A-Lisuride
13.64Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
13.64Single7XJHIsoprenaline7XJH-β3-Isoprenaline-Gs/β1/γ2
13.64Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
13.64Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.64Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
13.64Single8GCML-9026888GCM-EP4-L-902688-Gi1/β1/γ2
13.64Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
13.64Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.64Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
13.64Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
13.64Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.64Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
13.64Single8X63Mepyramine8X63-H1-Mepyramine
13.64Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.64Single9AS1DMT9AS1-5-HT2A-DMT
13.64Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
13.64Single9JROPF-044189489JRO-EP2-PF-04418948
13.64Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
13.64Single9LLAAriadne9LLA-5-HT2A-Ariadne-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Consensus5ht5_onOrthosteric Ligand5ht5a_on
13.64Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.64Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.64Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.64Consensusblt_onOrthosteric Ligandblt1_on
13.64Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
13.64Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.64Consensushistamine_offOrthosteric Ligandh1_off
13.64Consensusleukotriene_onOrthosteric Ligandblt_on
13.64Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
13.64Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
13.51Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
13.51Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
13.33Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
13.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.33Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
13.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
13.33Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
13.33Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
13.33Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
13.33Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.33Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.04Single4JKVTaladegib4JKV-SMO-Taladegib
13.04Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
13.04Single5CGCHTL142425CGC-mGlu5-HTL14242
13.04Single5N2RPSB365N2R-A2A-PSB36-Na
13.04Single5TVNLSD5TVN-5-HT2B-LSD
13.04Single5WQCEMPA5WQC-OX2-EMPA
13.04Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.04Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.04Single6E67BI1671076E67-β2-BI167107-Gs(CT)
13.04Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.04Single6TP6Filorexant6TP6-OX1-Filorexant
13.04Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
13.04Single6Z4SSR486926Z4S-NTS1-SR48692
13.04Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.04Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
13.04Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
13.04Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
13.04Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
13.04Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.04Single7W41PD1762527W41-BB2-PD176252
13.04Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
13.04Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.04Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
13.04Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
13.04Single8TF5Oleic acid8TF5-GPR6-Oleic acid
13.04Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
13.04Single8ZRKGSK12922638ZRK-GPR119-GSK1292263-Gs/β1/γ2
13.04Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
13.04Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
13.04Single9B9ZMRI-18679B9Z-CB1-MRI-1867
13.04Single9EE5ONO-25502899EE5-DP1-ONO-2550289
13.04Single9JRTTG6-1299JRT-EP2-TG6-129
13.04Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single9KUTJR14a9KUT-C3aB-JR14a-Go/β1/γ2
13.04Consensusadenosine_offOrthosteric Liganda1_off a2_off
13.04Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
13.04Consensusbombesin_offOrthosteric Ligandbb2_off
13.04Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
13.04Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
13.04Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.04Consensusep_offOrthosteric Ligandep4_off
13.04Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
13.04Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
12.90Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
12.90Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
12.90Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
12.90Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
12.90Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
12.90Single8IA2C5a8IA2-C5a1-C5a-Go/β1/γ2
12.90Consensuspac_onOrthosteric Ligandpac1_on
12.90Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
12.50Single3P0GBI1671073P0G-β2-BI167107
12.50Single3PDSFAUC503PDS-β2-FAUC50
12.50Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
12.50Single3ZEVNeurotensin-(7-13)3ZEV-NTS1-Neurotensin-(7-13)
12.50Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single4DJHJDTic4DJH-κ-JDTic
12.50Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
12.50Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
12.50Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single5V56TC1145V56-SMO-TC114
12.50Single5V57TC1145V57-SMO-TC114
12.50Single5XR8AM120335XR8-CB1-AM12033
12.50Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.50Single6P9YPACAP276P9Y-PAC1-PACAP27-Gs/β1/γ2
12.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
12.50Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.50Single7EW4CYM-55417EW4-S1P3-CYM-5541-Gi1/β1/γ2
12.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
12.50Single7L0PNeurotensin-(8-13)7L0P-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
12.50Single7L0QNeurotensin-(8-13)7L0Q-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
12.50Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
12.50Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.50Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
12.50Single7VABTirzepatide (non-acylated)7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
12.50Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
12.50Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
12.50Single8FN1Neurotensin-(8-13)8FN1-NTS1-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
12.50Single8I9LC3a8I9L-C3aB-C3a-Go/β1/γ2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
12.50Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8X0FVU298X0F-mGlu5; mGlu5-Quisqualate-VU29
12.50Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.50Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
12.50Single8ZWFJR14a8ZWF-C3aB-JR14a
12.50Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
12.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
12.50Single9EGOZ85267113509EGO-CB1-Z8526711350-Gi1/β1/γ2
12.50Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
12.50Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
12.50Single9L16CCL219L16-CCR7-CCL21
12.50Single9P92VIP9P92-PAC1-VIP-Gs/β1/γ2
12.50Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.50Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
12.50Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
12.50Consensuslpa_onOrthosteric Ligandlpa1_on
12.50Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
12.50Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-methyl-Scopolamine 5ZHP-M3-PubChem 134828589
12.50Consensusneurotensin_onOrthosteric Ligandnts1_on
12.50Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
12.50Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
12.50Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
12.50Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.50Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.50Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
12.50Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
12.12Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
12.12Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
12.12Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
12.12Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
12.12Single7S1MExendin-4-D-Ala7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
12.12Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
12.12Single8FU6ZP37808FU6-Glucagon-ZP3780-Gs/β1/γ2
12.12Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
12.12Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.12Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
12.12Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.12Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
12.12Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
12.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
12.00Single4XEENeurotensin-(8-13)4XEE-NTS1-Neurotensin-(8-13)
12.00Single4XESNeurotensin-(8-13)4XES-NTS1-Neurotensin-(8-13)
12.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
12.00Single6AK3PGE26AK3-EP3-PGE2
12.00Single6IIURamatroban6IIU-TXA2-Ramatroban
12.00Single6YVRNeurotensin-(6-13)6YVR-NTS1-Neurotensin-(6-13)
12.00Single7EO4Siponimod7EO4-S1P1-Siponimod-Gi1/β1/γ2
12.00Single7EW2FTY720-P7EW2-S1P3-FTY720-P-Gi1/β1/γ2
12.00Single7K15MKD0467K15-BLT1-MKD046-Na
12.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
12.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
12.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
12.00Single9BJKPubChem 1716420669BJK-μ-Naloxone-PubChem 171642066
12.00Single9KZKC3a (fragment)9KZK-C3aB-C3a (fragment)-Go/β1/γ2
12.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
12.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
12.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
12.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
12.00Consensuslpa_offOrthosteric Ligandlpa1_off
12.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
11.76Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
11.76Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
11.76Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.76Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
11.76Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
11.76Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
11.76Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
11.76Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
11.76Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
11.76Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
11.76Single7XKDDehydroepiandrosterone7XKD-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
11.76Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.76Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
11.76Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
11.76Single8PWNTheophylline8PWN-A2A-Theophylline
11.76Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.76Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
11.76Single9P93VIP9P93-PAC1-VIP-Gs/β1/γ2
11.76Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
11.76Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
11.76Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
11.54Single4BUONeurotensin-(8-13)4BUO-NTS1-Neurotensin-(8-13)
11.54Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
11.54Single5CGDHTL142425CGD-mGlu5-HTL14242
11.54Single6K1QIRL25006K1Q-ETB-IRL2500
11.54Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
11.54Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.54Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
11.54Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
11.54Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
11.54Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
11.54Single8FN0Neurotensin-(8-13)8FN0-NTS1-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
11.54Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
11.54Single8WRZAM8418WRZ-CB1-AM841-Arrestin2
11.54Single8XVJMacitentan8XVJ-ETA-Macitentan
11.54Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.43Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
11.11Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
11.11Single3RFMCaffeine3RFM-A2A-Caffeine
11.11Single6LPBPACAP276LPB-PAC1-PACAP27-Gs/β1/γ1
11.11Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.11Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
11.11Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
11.11Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.11Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
11.11Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8Y02All-trans-Retinal8Y02-OPN1SW-All-trans-Retinal-Gi1/β1/γ2
11.11Single8Z8ALactate8Z8A-HCA1-Lactate-Gi1/β1/γ2
11.11Single9IPYJR14a9IPY-C3aB-JR14a
11.11Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
11.11Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
11.11Consensussensory_onOrthosteric Ligandopsins_on
10.81Single6WPWZP37806WPW-Glucagon-ZP3780-Gs/β1/γ2
10.81Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
10.81Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
10.81Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
10.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.71Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
10.71Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
10.71Single8IZBLysophosphatidylserine (UBL)8IZB-GPR174-Lysophosphatidylserine (UBL)-Gs/β1/γ2
10.71Single9KWGC5a9KWG-C5a1-C5a-Go/β1/γ2
10.53Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.53Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
10.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.53Single6PWCNeurotensin-(9-13)6PWC-NTS1-Neurotensin-(9-13)-Arrestin2
10.53Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
10.53Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
10.53Single8J6QPubChem 251012238J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
10.53Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
10.53Single9JG1Adriforant9JG1-H4-Adriforant
10.53Single9KT93,5-DHBA9KT9-HCA1-3,5-DHBA-Gi1/β1/γ2
10.53Single9LL7DOI9LL7-5-HT2A-DOI-Gi1/β1/γ2
10.53Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
10.53Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.53Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.34Single7SK5CXCL127SK5-ACKR3-CXCL12
10.26Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
10.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
10.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6LI0C176LI0-GPR52-C17
10.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
10.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.00Single7UL2SR486927UL2-NTS1-SR48692-Na
10.00Single8J6PPubChem 251012238J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
10.00Single8JHYPubChem 251012238JHY-HCA2-PubChem 25101223-Gi1/β1/γ2
10.00Single8JIIPubChem 251012238JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
10.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
10.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
10.00Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
10.00Single9B9YTaranabant9B9Y-CB1-Taranabant
10.00Single9EPRAll-trans-Retinal9EPR-Rhodopsin-All-trans-Retinal-Gi1/β1/γ2
10.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
10.00Single9M88Oleic monoethanolamide9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
10.00Single9YDAAll-trans-Retinal9YDA-Opsin1MW-All-trans-Retinal-chim(NtGi1L-Gs-CtGt)/β1/γ2
10.00Consensusneurotensin_offOrthosteric Ligandnts1_off
10.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
9.76Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
9.68Single6M1IPACAP276M1I-PAC1-PACAP27-Gs/β1/γ2
9.68Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
9.68Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
9.68Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
9.68Single9BLCCagrilintide (non-acylated)9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
9.68Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
9.52Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
9.52Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
9.52Single4BWBNeurotensin-(8-12)4BWB-NTS1-Neurotensin-(8-12)
9.52Single4QINSAG1.54QIN-SMO-SAG1.5
9.52Single4S0VSuvorexant4S0V-OX2-Suvorexant
9.52Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
9.52Single5U09Taranabant5U09-CB1-Taranabant
9.52Single5WS3EMPA5WS3-OX2-EMPA
9.52Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.52Single6TPJSuvorexant6TPJ-OX2-Suvorexant
9.52Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
9.52Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.52Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
9.52Single7BR3Elagolix7BR3-GnRH1-Elagolix
9.52Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
9.52Single7F8ULintitript7F8U-CCKA-Lintitript
9.52Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
9.52Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
9.52Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
9.52Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
9.52Single7XRRLemborexant7XRR-OX2-Lemborexant
9.52Single8T3VDoconexent8T3V-FFA1-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.52Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.52Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
9.52Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
9.52Single9K6LSalicin9K6L-TAS2R16-Salicin-Gi2/β1/γ2
9.52Single9KPESalicin9KPE-TAS2R16-Salicin-Gi1/β1/γ2
9.52Single9LKDPL459LKD-OR5V1-PL45
9.52Single9M88Oleic monoethanolamide9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
9.52Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.52Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.52Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
9.52Consensusorexin_offOrthosteric Ligandox2_off ox1_off
9.52Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
9.52Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
9.52Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
9.38Single9E2AGLP-19E2A-GLP-1-GLP-1-Gs/β1/γ2
9.09Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
9.09Single6FJ3PTH6FJ3-PTH1-PTH
9.09Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.09Single6NBILA-PTH Analog6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
9.09Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
9.09Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
9.09Single6TP3Nemorexant6TP3-OX1-Nemorexant
9.09Single6V9SGTPL114036V9S-OX1-GTPL11403
9.09Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
9.09Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.09Single8K2WAMG4878K2W-CXCR3-AMG487
9.09Single8RLNLUF58348RLN-A2A-LUF5834
9.09Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
9.09Single8Y01All-trans-Retinal8Y01-Opsin1MW-All-trans-Retinal-Gi1/β1/γ2
9.09Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
9.09Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9BA0MRI-18919BA0-CB1-MRI-1891
9.09Single9BLBCagrilintide (non-acylated)9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
9.09Single9BLWCagrilintide (non-acylated)9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
9.09Single9JQYTG6-1299JQY-EP4-TG6-129
9.09Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9L8LBI1671079L8L-β2-BI167107-Atazanavir-Gs/β1/γ2 ; Arrestin2
9.09Single9LKBPL459LKB-OR5V1-PL45-chim(NtGi1-Gs)/β1
9.09Single9M2FNeuropeptide-FF9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
9.09Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
9.09Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
9.09Consensusgrh_offOrthosteric Ligandgnrh1_off
8.89Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
8.82Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
8.82Single6P9XCorticoliberin-16P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
8.82Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
8.82Single9P94PACAP279P94-PAC1-PACAP27-Gs/β1/γ2
8.70Single5T04Neurotensin-(8-13)5T04-NTS1-Neurotensin-(8-13)
8.70Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
8.70Single6GPSMK08126GPS-CCR2-MK0812
8.70Single6IIVDaltroban6IIV-TXA2-Daltroban
8.70Single6Z4VNeurotensin-(9-13)6Z4V-NTS1-Neurotensin-(9-13)
8.70Single7F83PF-051904577F83-Ghrelin-PF-05190457
8.70Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
8.70Single7V3ZCP559407V3Z-CB1-CP55940
8.70Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
8.70Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
8.70Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
8.70Single9IYAONO-97105319IYA-GPR55-ONO-9710531
8.70Single9JQZGrapiprant 9JQZ-EP4-Grapiprant
8.70Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
8.70Consensuscck_offOrthosteric Ligandccka_off
8.70Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
8.70Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
8.70Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
8.57Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
8.57Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
8.57Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
8.57Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
8.57Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
8.57Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
8.57Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
8.33Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
8.33Single5XPRBosentan5XPR-ETB-Bosentan
8.33Single6GPXMK08126GPX-CCR2-MK0812
8.33Single6KPCAM120336KPC-CB2-AM12033
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
8.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
8.33Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.33Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
8.33Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
8.33Single9HC04YI9HC0-mGlu5-4YI
8.33Single9KO4CCL219KO4-CCR7-CCL21-Gi1/β1/γ2
8.33Single9M8POleic monoethanolamide9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
8.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
8.33Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
8.33Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
8.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.11Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
8.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
8.11Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
8.11Single8FLULA-PTH Analog8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
8.00Single4BV0Neurotensin-(7-13)4BV0-NTS1-Neurotensin-(7-13)
8.00Single5XRAAM115425XRA-CB1-AM11542
8.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
8.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
8.00Single7P2L4YI7P2L-mGlu5-4YI
8.00Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
8.00Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.00Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
8.00Single9IZGLPA9IZG-LPA1-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
7.89Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
7.69Single6KQICP559406KQI-CB1-CP55940-Org27569
7.69Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.69Single7EPENAM5637EPE-mGlu2-NAM563
7.69Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
7.69Single7Y36PTH7Y36-PTH1-PTH-Gs/β1/γ2
7.69Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
7.69Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
7.69Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
7.69Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
7.69Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
7.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
7.50Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.50Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
7.50Consensuspth_onOrthosteric Ligandpth1_on pth2_on
7.41Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
7.32Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
7.14Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
7.14Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
7.14Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.98Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
6.90Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
6.90Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
6.90Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
6.90Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
6.82Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
6.82Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
6.67Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
6.67Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
6.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
6.67Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
6.67Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
6.45Single9B5YLA-PTH Analog9B5Y-PTH1-LA-PTH Analog-chim(NtGi1-Gq)/β1/γ2
6.45Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.45Single9LXRLA-PTH Analog9LXR-PTH1-LA-PTH Analog-Arrestin2
6.45Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
6.45Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
6.25Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.06Single5YQZNNC17025YQZ-Glucagon-NNC1702
6.06Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.06Consensuscalcitonin_onOrthosteric Ligandctlike_on
5.88Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.88Single6NBFLA-PTH Analog6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
5.88Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
5.88Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
5.88Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
5.88Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
5.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
5.71Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
5.71Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
5.56Single6NBHLA-PTH Analog6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
5.56Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
5.56Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
5.56Single7XKEDehydroepiandrosterone7XKE-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
5.56Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
5.56Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
5.56Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
5.56Single9JKVPubChem 27366909JKV-HCA3-PubChem 2736690-Gi1/β1/γ2
5.41Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
5.26Single3OE8IT1t3OE8-CXCR4-IT1t
5.26Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.26Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.26Single9L0HJR14a9L0H-C3aB-JR14a-Go/β1/γ2
5.13Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
5.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
5.00Single8JPSCCL78JPS-ACKR1-CCL7
5.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
4.76Single6TP4ACT-4622066TP4-OX1-ACT-462206
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.76Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
4.76Single9JLCAVE 09919JLC-MAS1-AVE 0991-Gi1/β1/γ2
4.76Single9MBCAZ122160529MBC-mGlu8; mGlu8-DCPG-AZ12216052
4.55Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
4.55Single7F8YDevazepide7F8Y-CCKA-Devazepide
4.55Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
4.55Single8DWGML3828DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
4.35Single8IYXYL-3658IYX-GPR34-YL-365
4.35Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35Single9KPDSalicin9KPD-TAS2R16-Salicin-chim(Gs-CtGt3)/β1/γ2
4.17Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.17Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.17Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.17Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.17Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.17Single8ZYYNeurotensin-(8-13)8ZYY-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
4.17Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9IMATalquetamab9IMA-GPRC5D; GPRC5D-Talquetamab
4.17Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
4.00Single9KPFSalicin9KPF-TAS2R16-Salicin-Gi1/β1/γ2
4.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
4.00Consensusblt_offOrthosteric Ligandblt1_off
3.85Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.85Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
3.70Single5X33BIIL2605X33-BLT1-BIIL260
3.70Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.70Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
3.57Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
3.57Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
3.45Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.45Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.33Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
3.12Single8YFOAc-LA-PTH Analog8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
3.03Single6NIYCalcitonin-16NIY-CT-Calcitonin-1-Gs/β1/γ2
2.94Single7TYHCalcitonin7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
2.94Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
2.94Single8YG4LA-PTH Analog8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
2.78Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
2.78Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2

PDB Summary
PDB 9WXM
Class A
SubFamily Orphan
Type Orphan
SubType GPR15
Species Homo Sapiens
Ligand GPR15L(CT)
Other Ligand(s) -
Protein Partners Gi3/Beta1/Gamma2
PDB Resolution 3.3
Date 2025-11-19
D.O.I. 10.1016/j.isci.2025.113935
Net Summary
Imin 2.79
Number of Linked Nodes 844
Number of Links 1000
Number of Hubs 148
Number of Links mediated by Hubs 566
Number of Communities 34
Number of Nodes involved in Communities 227
Number of Links involved in Communities 306
Path Summary
Number Of Nodes in MetaPath 130
Number Of Links MetaPath 129
Number of Shortest Paths 1518097
Length Of Smallest Path 3
Average Path Length 41.738
Length of Longest Path 87
Minimum Path Strength 1.23
Average Path Strength 5.95263
Maximum Path Strength 22.6
Minimum Path Correlation 0.7
Average Path Correlation 0.983773
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 37.8199
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.1797
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • GDP binding   • G-protein beta/gamma-subunit complex binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • cell division   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • positive regulation of autophagy   • catabolic process   • macroautophagy   • autophagy   • positive regulation of biological process   • regulation of catabolic process   • regulation of autophagy   • positive regulation of catabolic process   • positive regulation of metabolic process   • regulation of macroautophagy   • metabolic process   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • regulation of metabolic process   • positive regulation of cellular process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • purine nucleoside triphosphate metabolic process   • GTP metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • nucleoside triphosphate metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • sperm principal piece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • virus receptor activity   • exogenous protein binding   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • blood vessel morphogenesis   • tube development   • angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • tube morphogenesis   • anatomical structure formation involved in morphogenesis   • blood vessel development   • biological process involved in interspecies interaction between organisms   • symbiont entry into host cell   • viral process   • symbiont entry into host   • viral life cycle   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • endosome   • intracellular vesicle   • cytoplasmic vesicle   • molecular function activator activity   • signaling receptor activator activity   • cytokine receptor binding   • chemokine activity   • molecular function regulator activity   • cytokine activity   • signaling receptor regulator activity   • chemokine receptor binding   • receptor ligand activity   • regulation of cell motility   • regulation of leukocyte migration   • regulation of lymphocyte migration   • regulation of locomotion   • regulation of T cell migration   • regulation of cell migration   • regulation of immune system process   • regulation of mononuclear cell migration   • locomotion   • establishment of organelle localization   • regulated exocytosis   • cellular localization   • transport   • cell activation involved in immune response   • leukocyte degranulation   • myeloid leukocyte activation   • myeloid leukocyte mediated immunity   • vesicle-mediated transport   • leukocyte activation   • localization   • secretion by cell   • organelle localization   • leukocyte activation involved in immune response   • establishment of localization in cell   • mast cell activation   • leukocyte mediated immunity   • mast cell mediated immunity   • immune response   • secretion   • cell activation   • vacuolar localization   • export from cell   • mast cell degranulation   • establishment of localization   • myeloid cell activation involved in immune response   • immune effector process   • mast cell activation involved in immune response   • exocytosis   • lysosome localization   • defense response to fungus   • response to other organism   • defense response   • response to stress   • response to external stimulus   • response to fungus   • response to external biotic stimulus   • response to biotic stimulus   • regulation of cell population proliferation   • regulation of keratinocyte proliferation   • regulation of epithelial cell proliferation   • epithelial cell proliferation   • keratinocyte proliferation   • multicellular organismal-level homeostasis   • leukocyte homeostasis   • T cell homeostasis   • homeostatic process   • homeostasis of number of cells   • lymphocyte homeostasis   • cell chemotaxis   • chemotaxis   • lymphocyte chemotaxis   • taxis   • leukocyte chemotaxis   • regulation of cell cycle phase transition   • regulation of cell cycle process   • negative regulation of cell cycle G1/S phase transition   • negative regulation of biological process   • negative regulation of cell cycle   • cell cycle phase transition   • regulation of cell cycle G1/S phase transition   • negative regulation of cell cycle process   • cell cycle G1/S phase transition   • negative regulation of cellular process   • negative regulation of cell cycle phase transition   • cell cycle   • regulation of cell cycle   • cell cycle process   • negative regulation of cell division   • regulation of cell division   • defense response to Gram-positive bacterium   • defense response to bacterium   • response to bacterium
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP08754
Sequence
>9WXM_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAKEVKLLL LGAGESGKT 
IVKQMKTGI VETHFTFKD LYFKMFDVQ RSERKKWIH CFEGVTAII 
FCVALSDYD LVLMNRMHS MKLFDSICN NKWFTETSI ILFLNKKDL 
FEEKIKRSP LTICYPEYT GSNTYEEAA AYIQCQFED LNRRKDTKE 
IYTHFTCTD TKNVQFVFD AVTDVIIKN NLKECGLYC TAAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9WXM_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9WXM_Chain_G
AQARKLVEQ LKMEANIDR IKVSKAAAD LMAYCEAHA KEDPLLTPV 
PASENPFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainL
ProteinGPR15L(CT)
UniProtQ6UWK7
Sequence
>9WXM_Chain_L
EPRLWVVPG ALPQV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP49685
Sequence
>9WXM_Chain_R
TSVFLPVFY TAVFLTGVL GNLVLMGAL HFKPGSRRL IDIFIINLA 
ASDFIFLVT LPLWVDKEA SLGLWRTGS FLCKGSSYM ISVNMHCSV 
LLLTCMSVD RYLAIVWPV VSRKFRRTD CAYVVCASI WFISCLLGL 
PTLLSRELT LIDDKPYCA EKKATPIKL IWSLVALIF TFFVPLLSI 
VTCYCCIAR KLCAHYQQS GKHNKKLKK SIKIIFIVV AAFLVSWLP 
FNTFKFLAI VSGLRQEHY LPSAILQLG MEVSGPLAF ANSCVNPFI 
YYIFDSYIR RAIVHCLC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EWLCOrphanOrphanGPR158; GPR158Homo sapiens---3.522021-12-01doi.org/10.1038/s41467-021-27147-1
7EWPCOrphanOrphanGPR158; GPR158Homo sapiens--B5; RGS74.32021-12-01doi.org/10.1038/s41467-021-27147-1
7EWRCOrphanOrphanGPR158; GPR158Homo sapiens--B5; RGS74.72021-12-01doi.org/10.1038/s41467-021-27147-1
7SHECOrphanOrphanGPR158; GPR158Homo sapiens---3.42021-12-01doi.org/10.1126/science.abl4732
7SHFCOrphanOrphanGPR158; GPR158Homo sapiens--B5; RGS73.42021-12-01doi.org/10.1126/science.abl4732
8ZQEAOrphanOrphanGPR15Homo sapiensGPR15L(CT)-Gi1/β1/γ12.92024-07-10doi.org/10.1038/s41421-024-00698-5
8ZQE (No Gprot) AOrphanOrphanGPR15Homo sapiensGPR15L(CT)-2.92024-07-10doi.org/10.1038/s41421-024-00698-5
8IEBCOrphanOrphanGPR156; GPR156Homo sapiensPubChem 134746894--3.032024-02-14doi.org/10.1038/s41594-024-01224-7
8IEDCOrphanOrphanGPR156; GPR156Homo sapiensPubChem 134746894-Go/β1/γ23.332024-02-14doi.org/10.1038/s41594-024-01224-7
8IED (No Gprot) COrphanOrphanGPR156; GPR156Homo sapiensPubChem 134746894-3.332024-02-14doi.org/10.1038/s41594-024-01224-7
8IEICOrphanOrphanGPR156; GPR156Homo sapiensPubChem 134746894--2.622024-02-14doi.org/10.1038/s41594-024-01224-7
8IEPCOrphanOrphanGPR156; GPR156Homo sapiensPubChem 134746894--2.612024-02-14doi.org/10.1038/s41594-024-01224-7
8YJPCOrphanOrphanGPR156; GPR156Homo sapiens---3.092025-02-05doi.org/10.1038/s41467-024-54681-5
8YK0COrphanOrphanGPR156; GPR156Homo sapiens--Gi3/β1/γ22.42025-02-05doi.org/10.1038/s41467-024-54681-5
8YK0 (No Gprot) COrphanOrphanGPR156; GPR156Homo sapiens--2.42025-02-05doi.org/10.1038/s41467-024-54681-5
9WXMAOrphanOrphanGPR15Homo sapiensGPR15L(CT)-Gi3/β1/γ23.32025-11-1910.1016/j.isci.2025.113935
9WXM (No Gprot) AOrphanOrphanGPR15Homo sapiensGPR15L(CT)-3.32025-11-1910.1016/j.isci.2025.113935
9LHQB2OrphanOrphanGPR155Homo sapiens---3.462025-12-1010.1016/j.scib.2025.09.012
9LHVB2OrphanOrphanGPR155; GPR155Homo sapiens---2.792025-12-1010.1016/j.scib.2025.09.012
9LHXB2OrphanOrphanGPR155; GPR155Homo sapiens---5.622025-12-1010.1016/j.scib.2025.09.012
9VORCOrphanOrphanGPR158; GPR158Homo sapiens---3.472025-12-31To be published




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