psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G67	R:R:L70	5.13	No	Yes	0	3	4
2	R:R:G67	R:R:H328	4.77	No	No	0	3	9
3	R:R:I69	R:R:K73	7.27	No	No	0	4	4
4	R:R:K73	R:R:L70	7.05	No	Yes	0	4	4
5	R:R:L108	R:R:L70	2.77	No	Yes	0	4	4
6	R:R:A71	R:R:K329	8.03	No	No	0	5	5
7	R:R:H331	R:R:Q72	11.13	No	No	0	8	4
8	R:R:E77	R:R:L74	2.65	No	No	0	5	4
9	R:R:L105	R:R:L74	6.92	No	No	0	5	4
10	R:R:E77	R:R:V78	4.28	No	No	0	5	5
11	R:R:L94	R:R:M80	8.48	No	No	0	9	5
12	R:R:A83	R:R:D90	4.63	No	Yes	0	7	7
13	R:R:E104	R:R:Y85	3.37	No	No	4	7	8
14	R:R:W281	R:R:Y85	6.75	Yes	No	4	9	8
15	R:R:E387	R:R:L86	2.65	No	No	0	4	8
16	R:R:G89	R:R:Y87	10.14	No	No	0	7	6
17	R:R:D90	R:R:Y87	8.05	Yes	No	19	7	6
18	R:R:Q93	R:R:Y87	2.25	Yes	No	19	4	6
19	R:R:G89	R:R:T88	1.82	No	No	0	7	7
20	R:R:G357	R:R:T88	3.64	No	No	0	9	7
21	R:R:D90	R:R:Q93	14.36	Yes	Yes	19	7	4
22	R:R:D90	R:R:L94	5.43	Yes	No	0	7	9
23	R:R:K278	R:R:S91	7.65	No	No	0	5	4
24	R:R:H92	R:R:Q93	14.84	No	Yes	0	4	4
25	R:R:L94	R:R:S276	4.5	No	No	0	9	4
26	R:R:N274	R:R:R96	18.08	No	No	0	5	3
27	R:R:C99	R:R:R102	6.96	No	No	4	9	5
28	R:R:C272	R:R:C99	7.28	No	No	4	9	9
29	R:R:G101	R:R:S100	1.86	No	Yes	4	4	7
30	R:R:L270	R:R:S100	9.01	Yes	Yes	4	9	7
31	R:R:S100	R:R:S276	3.26	Yes	No	0	7	4
32	R:R:G101	R:R:L270	5.13	No	Yes	4	4	9
33	R:R:R102	R:R:Y269	10.29	No	No	0	5	5
34	R:R:C272	R:R:R102	4.18	No	No	4	9	5
35	R:R:L105	R:R:Y103	5.86	No	No	0	5	5
36	R:R:P267	R:R:Y103	5.56	No	No	0	5	5
37	R:R:E104	R:R:P268	4.72	No	Yes	4	7	9
38	R:R:E104	R:R:W281	3.27	No	Yes	4	7	9
39	R:R:A106	R:R:W112	2.59	No	Yes	4	3	4
40	R:R:A106	R:R:F324	2.77	No	Yes	4	3	9
41	R:R:L108	R:R:P109	3.28	No	No	0	4	4
42	R:R:H328	R:R:L108	6.43	No	No	0	9	4
43	R:R:G110	R:R:P109	2.03	No	No	0	6	4
44	R:R:K111	R:R:W112	3.48	No	Yes	4	3	4
45	R:R:K111	R:R:W265	4.64	No	Yes	4	3	7
46	R:R:P113	R:R:W112	5.4	No	Yes	4	5	4
47	R:R:W112	R:R:W265	11.25	Yes	Yes	4	4	7
48	R:R:P268	R:R:W112	5.4	Yes	Yes	4	9	4
49	R:R:W112	R:R:W323	3.75	Yes	Yes	4	4	9
50	R:R:F324	R:R:W112	2	Yes	Yes	4	9	4
51	R:R:A116	R:R:P113	3.74	No	No	0	7	5
52	R:R:P113	R:R:W323	6.76	No	Yes	4	5	9
53	R:R:D316	R:R:S117	5.89	No	No	0	8	4
54	R:R:A118	R:R:L122	3.15	No	No	0	4	7
55	R:R:A118	R:R:W323	5.19	No	Yes	0	4	9
56	R:R:H119	R:R:V313	8.3	No	No	0	4	6
57	R:R:D314	R:R:H119	8.82	No	No	0	8	4
58	R:R:S121	R:R:S170	4.89	No	No	0	4	5
59	R:R:R124	R:R:T128	3.88	No	No	0	5	8
60	R:R:E168	R:R:R124	9.3	Yes	No	0	8	5
61	R:R:R124	S:S:D127	15.48	No	No	0	5	5
62	R:R:A125	R:R:E168	3.02	No	Yes	20	7	8
63	R:R:A125	R:R:I171	3.25	No	No	20	7	8
64	R:R:F263	R:R:L126	2.44	Yes	No	0	6	4
65	R:R:L126	R:R:L285	5.54	No	No	0	4	9
66	R:R:L129	R:R:T133	2.95	Yes	Yes	7	6	8
67	R:R:L129	R:R:S287	3	Yes	Yes	7	6	7
68	R:R:L129	R:R:M304	5.65	Yes	Yes	7	6	7
69	R:R:L129	R:R:V306	7.45	Yes	No	0	6	7
70	R:R:H131	R:R:T130	5.48	Yes	Yes	7	7	4
71	R:R:T130	R:R:T133	3.14	Yes	Yes	7	4	8
72	R:R:N134	R:R:T130	4.39	No	Yes	7	9	4
73	R:R:F263	R:R:T130	6.49	Yes	Yes	7	6	4
74	R:R:H131	R:R:N134	3.83	Yes	No	7	7	9
75	R:R:H131	S:S:R124	6.77	Yes	No	0	7	5
76	R:R:H131	S:S:T128	6.85	Yes	No	7	7	8
77	R:R:H131	S:S:H131	11.94	Yes	No	7	7	7
78	R:R:A132	R:R:L164	3.15	No	No	0	9	5
79	R:R:N134	R:R:T133	2.92	No	Yes	7	9	8
80	R:R:F263	R:R:T133	2.59	Yes	Yes	7	6	8
81	R:R:S287	R:R:T133	3.2	Yes	Yes	7	7	8
82	R:R:F135	R:R:L160	7.31	Yes	No	11	8	9
83	R:R:F135	S:S:F135	7.5	Yes	Yes	11	8	8
84	R:R:F135	S:S:A159	2.77	Yes	No	0	8	9
85	R:R:F135	S:S:L160	6.09	Yes	Yes	11	8	9
86	R:R:F135	S:S:S163	6.61	Yes	No	11	8	8
87	R:R:L136	R:R:L160	4.15	No	No	0	9	9
88	R:R:I289	R:R:L136	2.85	No	No	0	8	9
89	R:R:L140	R:R:N137	5.49	Yes	No	0	8	9
90	R:R:V138	S:S:A159	3.39	No	No	0	6	9
91	R:R:V138	S:S:W162	9.81	No	Yes	0	6	7
92	R:R:M139	R:R:S142	4.6	Yes	No	5	7	7
93	R:R:M139	R:R:S145	6.13	Yes	No	5	7	9
94	R:R:M139	S:S:W156	4.65	Yes	Yes	5	7	9
95	R:R:M139	S:S:A159	3.22	Yes	No	0	7	9
96	R:R:L140	R:R:Q141	2.66	Yes	No	0	8	9
97	R:R:L140	R:R:L292	2.77	Yes	No	0	8	9
98	R:R:S142	R:R:S145	6.52	No	No	5	7	9
99	R:R:S142	S:S:D155	4.42	No	No	0	7	7
100	R:R:K144	S:S:Q151	8.14	No	No	21	7	5
101	R:R:K144	S:S:D152	9.68	No	No	21	7	6
102	R:R:E147	R:R:Q148	3.82	No	No	5	9	6
103	R:R:E147	R:R:L150	10.6	No	No	5	9	5
104	R:R:D153	R:R:E147	15.59	No	No	5	9	9
105	R:R:L150	R:R:Q148	13.31	No	No	5	5	6
106	R:R:L154	R:R:N149	2.75	No	No	0	5	7
107	R:R:F178	R:R:N149	3.62	Yes	No	5	6	7
108	R:R:N149	R:R:Q189	5.28	No	Yes	5	7	6
109	R:R:L150	R:R:Q151	3.99	No	Yes	5	5	5
110	R:R:D152	R:R:Q151	2.61	No	Yes	5	6	5
111	R:R:Q151	S:S:K144	2.71	Yes	No	5	5	7
112	R:R:Q151	S:S:R146	7.01	Yes	Yes	5	5	8
113	R:R:D152	S:S:R146	14.29	No	Yes	5	6	8
114	R:R:D153	R:R:Y157	12.64	No	No	5	9	9
115	R:R:D153	S:S:W156	4.47	No	Yes	5	9	9
116	R:R:L154	R:R:Q158	3.99	No	No	0	5	8
117	R:R:F191	R:R:L154	4.87	No	No	0	8	5
118	R:R:D155	R:R:Q158	5.22	No	No	0	7	8
119	R:R:D155	S:S:S142	5.89	No	No	0	7	7
120	R:R:D155	S:S:K144	2.77	No	No	0	7	7
121	R:R:W156	S:S:F135	4.01	Yes	Yes	0	9	8
122	R:R:W156	S:S:M139	16.29	Yes	No	0	9	7
123	R:R:W156	S:S:W156	56.23	Yes	Yes	0	9	9
124	R:R:W156	S:S:Y157	6.75	Yes	Yes	0	9	9
125	R:R:F178	R:R:Y157	11.35	Yes	No	5	6	9
126	R:R:Y157	S:S:W156	3.86	No	Yes	5	9	9
127	R:R:I201	R:R:Q158	4.12	No	No	0	9	8
128	R:R:A159	S:S:V138	3.39	No	Yes	0	9	6
129	R:R:L160	S:S:F135	3.65	No	Yes	11	9	8
130	R:R:I176	R:R:V161	6.14	No	No	0	7	9
131	R:R:Q193	R:R:V161	5.73	No	No	0	8	9
132	R:R:E166	R:R:W162	8.72	No	Yes	16	8	7
133	R:R:S199	R:R:W162	2.47	No	Yes	0	3	7
134	R:R:R200	R:R:W162	2	No	Yes	0	5	7
135	R:R:W162	S:S:V138	2.45	Yes	Yes	16	7	6
136	R:R:A174	R:R:L165	3.15	No	No	0	9	6
137	R:R:L165	R:R:Q193	3.99	No	No	0	6	8
138	R:R:L165	R:R:S199	3	No	No	0	6	3
139	R:R:E166	S:S:N134	11.83	No	No	16	8	9
140	R:R:E166	S:S:V138	7.13	No	Yes	16	8	6
141	R:R:E168	R:R:P169	7.86	Yes	No	0	8	4
142	R:R:E168	R:R:S170	5.75	Yes	No	0	8	5
143	R:R:E168	R:R:I171	6.83	Yes	No	20	8	8
144	R:R:P169	R:R:R196	14.41	No	No	0	4	8
145	R:R:I308	R:R:S170	3.1	No	No	0	6	5
146	R:R:I171	R:R:V306	6.14	No	No	0	8	7
147	R:R:A175	R:R:R173	5.53	No	Yes	23	7	7
148	R:R:L192	R:R:R173	12.15	No	Yes	0	9	7
149	R:R:K305	R:R:R173	3.71	No	Yes	23	8	7
150	R:R:D307	R:R:R173	4.76	No	Yes	0	9	7
151	R:R:A175	R:R:K305	3.21	No	No	23	7	8
152	R:R:F191	R:R:I176	2.51	No	No	0	8	7
153	R:R:I176	R:R:M304	5.83	No	Yes	0	7	7
154	R:R:G302	R:R:T177	5.46	No	No	0	9	8
155	R:R:F178	R:R:Q189	2.34	Yes	Yes	5	6	6
156	R:R:F178	R:R:F300	4.29	Yes	No	0	6	8
157	R:R:A187	R:R:P188	1.87	No	No	0	4	8
158	R:R:A187	R:R:Q189	3.03	No	Yes	0	4	6
159	R:R:L203	R:R:Q189	2.66	No	Yes	0	9	6
160	R:R:Q204	R:R:V190	5.73	No	No	0	8	7
161	R:R:F191	R:R:L203	8.53	No	No	0	8	9
162	R:R:L192	R:R:L202	2.77	No	No	0	9	4
163	R:R:L192	R:R:Q204	6.65	No	No	0	9	8
164	R:R:I201	R:R:Q193	8.23	No	No	0	9	8
165	R:R:D259	R:R:E299	11.69	No	No	0	6	8
166	R:R:H262	R:R:S261	2.79	No	No	0	6	4
167	R:R:F263	R:R:S287	2.64	Yes	Yes	7	6	7
168	R:R:V283	R:R:W265	2.45	No	Yes	0	6	7
169	R:R:L285	R:R:W265	9.11	No	Yes	0	9	7
170	R:R:P267	R:R:S266	3.56	No	No	0	5	8
171	R:R:S266	R:R:T284	4.8	No	No	0	8	8
172	R:R:P267	R:R:P268	1.95	No	Yes	0	5	9
173	R:R:P268	R:R:W281	5.4	Yes	Yes	4	9	9
174	R:R:L270	R:R:W281	3.42	Yes	Yes	4	9	9
175	R:R:E271	R:R:E273	3.81	No	No	24	8	5
176	R:R:E271	R:R:Y277	6.73	No	No	24	8	8
177	R:R:E271	R:R:P279	6.29	No	No	0	8	9
178	R:R:E273	R:R:Y277	8.98	No	No	24	5	8
179	R:R:Q311	R:R:W281	7.67	No	Yes	0	9	9
180	R:R:G357	R:R:W281	2.81	No	Yes	0	9	9
181	R:R:F358	R:R:W281	17.04	No	Yes	0	7	9
182	R:R:L310	R:R:V283	2.98	Yes	No	0	8	6
183	R:R:D307	R:R:T284	5.78	No	No	0	9	8
184	R:R:I308	R:R:L285	2.85	No	No	0	6	9
185	R:R:M304	R:R:S287	4.6	Yes	Yes	7	7	7
186	R:R:F300	R:R:I289	6.28	No	No	0	8	8
187	R:R:I289	R:R:M304	8.75	No	Yes	0	8	7
188	R:R:L292	R:R:Y290	3.52	No	No	0	9	8
189	R:R:I308	R:R:V306	3.07	No	No	0	6	7
190	R:R:N309	R:R:Q311	9.24	No	No	0	7	9
191	R:R:L310	R:R:V313	4.47	Yes	No	0	8	6
192	R:R:L310	R:R:W323	2.28	Yes	Yes	0	8	9
193	R:R:F358	R:R:L310	3.65	No	Yes	0	7	8
194	R:R:D314	R:R:P361	3.22	No	Yes	8	8	5
195	R:R:D314	R:R:V363	2.92	No	No	8	8	2
196	R:R:F358	R:R:I315	8.79	No	No	0	7	8
197	R:R:D316	R:R:S320	7.36	No	No	0	8	4
198	R:R:D316	R:R:G322	5.03	No	No	0	8	5
199	R:R:Q317	R:R:S319	2.89	No	No	0	9	7
200	R:R:Q317	R:R:S320	4.33	No	No	0	9	4
201	R:R:Q317	R:R:Y350	9.02	No	Yes	0	9	9
202	R:R:C318	R:R:S325	5.16	No	No	8	9	7
203	R:R:C318	R:R:Y350	9.41	No	Yes	8	9	9
204	R:R:C318	R:R:C354	7.28	No	Yes	8	9	9
205	R:R:E351	R:R:S319	5.75	Yes	No	0	4	7
206	R:R:D321	R:R:T327	10.12	No	No	0	5	9
207	R:R:F324	R:R:W323	5.01	Yes	Yes	4	9	9
208	R:R:F324	R:R:K355	3.72	Yes	No	0	9	6
209	R:R:K329	R:R:S325	10.71	No	No	0	5	7
210	R:R:C354	R:R:S325	6.89	Yes	No	8	9	7
211	R:R:G326	R:R:T327	1.82	No	No	0	6	9
212	R:R:H328	R:R:T327	2.74	No	No	0	9	9
213	R:R:C330	R:R:N333	4.72	Yes	Yes	2	9	9
214	R:R:C330	R:R:N334	6.3	Yes	No	2	9	7
215	R:R:C330	R:R:E351	12.15	Yes	Yes	2	9	4
216	R:R:C330	R:R:C352	7.28	Yes	No	2	9	9
217	R:R:H331	R:R:L332	3.86	No	Yes	2	8	6
218	R:R:H331	R:R:Y390	7.62	No	No	2	8	5
219	R:R:L332	R:R:N333	2.75	Yes	Yes	2	6	9
220	R:R:E336	R:R:L332	7.95	No	Yes	0	6	6
221	R:R:A389	R:R:L332	4.73	No	Yes	0	4	6
222	R:R:L332	R:R:Y390	8.21	Yes	No	2	6	5
223	R:R:C352	R:R:N333	7.87	No	Yes	2	9	9
224	R:R:N333	R:R:R370	9.64	Yes	Yes	2	9	1
225	R:R:E351	R:R:N334	14.46	Yes	No	2	4	7
226	R:R:C337	R:R:E336	3.04	Yes	No	0	9	6
227	R:R:C337	R:R:K341	6.47	Yes	Yes	2	9	3
228	R:R:C337	R:R:R370	12.54	Yes	Yes	2	9	1
229	R:R:C337	R:R:H377	17.69	Yes	Yes	2	9	3
230	R:R:C337	R:R:C392	5.46	Yes	Yes	2	9	9
231	R:R:M338	R:R:P339	5.03	No	No	0	3	8
232	R:R:G344	R:R:M338	3.49	Yes	No	0	9	3
233	R:R:M338	R:R:V346	3.04	No	No	0	3	7
234	R:R:I340	R:R:Q376	5.49	No	No	0	5	3
235	R:R:H377	R:R:I340	10.61	Yes	No	2	3	5
236	R:R:I340	R:R:L393	2.85	No	No	2	5	6
237	R:R:G344	R:R:K341	3.49	Yes	Yes	2	9	3
238	R:R:K341	R:R:R370	13.61	Yes	Yes	2	3	1
239	R:R:K341	R:R:R372	21.04	Yes	Yes	2	3	1
240	R:R:D375	R:R:K341	16.59	No	Yes	2	1	3
241	R:R:H377	R:R:K341	27.51	Yes	Yes	2	3	3
242	R:R:G342	R:R:R372	6	No	Yes	2	6	1
243	R:R:D375	R:R:G342	5.03	No	No	2	1	6
244	R:R:F345	R:R:L343	7.31	No	No	0	9	4
245	R:R:G344	R:R:R372	4.5	Yes	Yes	2	9	1
246	R:R:E351	R:R:V346	7.13	Yes	No	0	4	7
247	R:R:R370	R:R:V346	22.23	Yes	No	0	1	7
248	R:R:G348	R:R:L347	5.13	No	No	0	9	9
249	R:R:E351	R:R:L347	2.65	Yes	No	0	4	9
250	R:R:F369	R:R:G348	9.03	No	No	0	1	9
251	R:R:I353	R:R:Y350	20.55	No	Yes	8	4	9
252	R:R:C354	R:R:Y350	2.69	Yes	Yes	8	9	9
253	R:R:P365	R:R:Y350	11.13	Yes	Yes	8	3	9
254	R:R:C352	R:R:E351	6.08	No	Yes	2	9	4
255	R:R:I353	R:R:P365	11.85	No	Yes	8	4	3
256	R:R:C354	R:R:K355	6.47	Yes	No	0	9	6
257	R:R:A356	R:R:G357	1.95	No	No	0	3	9
258	R:R:P361	R:R:Y359	13.91	Yes	No	0	5	9
259	R:R:H360	R:R:P365	10.68	No	Yes	0	6	3
260	R:R:G362	R:R:P361	2.03	No	Yes	0	3	5
261	R:R:P361	R:R:V363	3.53	Yes	No	8	5	2
262	R:R:P365	R:R:V363	3.53	Yes	No	8	3	2
263	R:R:F369	R:R:V366	14.42	No	No	0	1	4
264	R:R:G380	R:R:N368	3.39	No	No	0	3	4
265	R:R:H377	R:R:R370	2.26	Yes	Yes	2	3	1
266	R:R:C392	R:R:R370	6.96	Yes	Yes	2	9	1
267	R:R:R371	R:R:S379	7.91	No	Yes	0	1	3
268	R:R:G373	R:R:R372	4.5	No	Yes	2	1	1
269	R:R:P374	R:R:R372	4.32	No	Yes	2	1	1
270	R:R:D375	R:R:R372	30.97	No	Yes	2	1	1
271	R:R:H377	R:R:R372	3.39	Yes	Yes	2	3	1
272	R:R:G373	R:R:P374	4.06	No	No	2	1	1
273	R:R:P374	R:R:P400	7.79	No	No	0	1	3
274	R:R:Q376	R:R:R396	22.2	No	No	0	3	5
275	R:R:C392	R:R:H377	4.42	Yes	Yes	2	9	3
276	R:R:H377	R:R:L393	9	Yes	No	2	3	6
277	R:R:I378	R:R:S379	3.1	Yes	Yes	0	1	3
278	R:R:I378	R:R:P394	3.39	Yes	No	0	1	9
279	R:R:C395	R:R:I378	8.18	No	Yes	25	9	1
280	R:R:C402	R:R:I378	3.27	No	Yes	25	9	1
281	R:R:G380	R:R:S379	1.86	No	Yes	0	3	3
282	R:R:C392	R:R:G380	3.92	Yes	No	0	9	3
283	R:R:P394	R:R:T382	8.74	No	No	0	9	4
284	R:R:D384	R:R:K383	8.3	No	No	2	1	8
285	R:R:K383	R:R:V391	13.66	No	No	2	8	3
286	R:R:D384	R:R:Y390	9.2	No	No	2	1	5
287	R:R:D384	R:R:V391	5.84	No	No	2	1	3
288	R:R:E387	R:R:S386	10.06	No	No	0	4	4
289	R:R:E387	R:R:E388	5.07	No	No	0	4	3
290	R:R:C395	R:R:C402	7.28	No	No	25	9	9
291	R:R:E397	R:R:G398	4.91	Yes	No	0	6	8
292	R:R:D405	R:R:E397	7.8	No	Yes	0	7	6
293	R:R:C399	R:R:P400	1.88	Yes	No	0	9	3
294	R:R:C399	R:R:F401	5.59	Yes	No	17	9	4
295	R:R:C399	R:R:C408	7.28	Yes	No	17	9	9
296	R:R:C408	R:R:F401	2.79	No	No	17	9	4
297	R:R:A403	R:R:P407	1.87	No	Yes	0	3	9
298	R:R:P407	R:R:S406	5.34	Yes	No	0	9	5
299	R:R:E412	R:R:F409	10.49	No	No	0	7	3
300	R:R:F570	R:R:V410	6.55	No	No	0	9	6
301	R:R:Q639	R:R:V410	8.6	Yes	No	0	9	6
302	R:R:E412	R:R:R417	4.65	No	Yes	26	7	9
303	R:R:D641	R:R:E412	2.6	No	No	26	9	7
304	R:R:D413	R:R:L416	5.43	No	No	0	8	9
305	R:R:K414	R:R:L418	4.23	No	No	0	2	5
306	R:R:R417	R:R:Y473	5.14	Yes	Yes	0	9	8
307	R:R:R417	R:R:S640	3.95	Yes	No	0	9	8
308	R:R:D641	R:R:R417	8.34	No	Yes	26	9	9
309	R:R:L644	R:R:R417	4.86	No	Yes	0	9	9
310	R:R:L418	R:R:Y473	2.34	No	Yes	0	5	8
311	R:R:F648	R:R:I420	5.02	Yes	No	0	9	8
312	R:R:I421	R:R:Y473	9.67	No	Yes	0	7	8
313	R:R:C427	R:R:F423	2.79	No	No	9	8	5
314	R:R:F423	R:R:F648	4.29	No	Yes	9	5	9
315	R:R:F423	R:R:H652	7.92	No	Yes	9	5	9
316	R:R:M428	R:R:Q424	5.44	Yes	Yes	9	7	9
317	R:R:Q424	R:R:Y466	3.38	Yes	Yes	9	9	8
318	R:R:Q424	R:R:V470	4.3	Yes	No	0	9	7
319	R:R:F648	R:R:Q424	2.34	Yes	Yes	9	9	9
320	R:R:H652	R:R:Q424	2.47	Yes	Yes	9	9	9
321	R:R:C427	R:R:Y466	4.03	No	Yes	9	8	8
322	R:R:C427	R:R:H652	2.95	No	Yes	9	8	9
323	R:R:L463	R:R:M428	2.83	No	Yes	0	8	7
324	R:R:M428	R:R:Y466	7.18	Yes	Yes	9	7	8
325	R:R:F467	R:R:M428	4.98	Yes	Yes	0	7	7
326	R:R:D431	R:R:L459	2.71	No	No	0	6	9
327	R:R:D431	R:R:L463	4.07	No	No	0	6	8
328	R:R:D431	R:R:I659	2.8	No	No	0	6	7
329	R:R:L459	R:R:S434	3	No	No	0	9	8
330	R:R:L663	R:R:S434	6.01	No	No	0	8	8
331	R:R:E456	R:R:M435	9.47	No	No	0	9	9
332	R:R:L459	R:R:M435	2.83	No	No	0	9	9
333	R:R:F441	R:R:V437	2.62	No	No	0	6	4
334	R:R:F667	R:R:V437	2.62	Yes	No	0	8	4
335	R:R:F667	R:R:V438	2.62	Yes	No	0	8	7
336	R:R:R442	R:R:Y439	16.46	No	No	0	9	9
337	R:R:F441	R:R:H440	7.92	No	No	0	6	7
338	R:R:K443	R:R:R442	13.61	No	No	0	4	9
339	R:R:K443	R:R:R448	6.19	No	No	0	4	8
340	R:R:F607	R:R:K445	3.72	No	No	0	8	8
341	R:R:F607	R:R:S446	2.64	No	No	0	8	8
342	R:R:K666	R:R:S446	3.06	Yes	No	0	9	8
343	R:R:I447	R:R:L452	2.85	No	No	0	9	7
344	R:R:F667	R:R:I447	2.51	Yes	No	0	8	9
345	R:R:K502	R:R:S450	3.06	Yes	No	1	9	9
346	R:R:E609	R:R:S450	5.75	Yes	No	1	9	9
347	R:R:K666	R:R:S450	6.12	Yes	No	1	9	9
348	R:R:K502	R:R:L454	4.23	Yes	No	1	9	9
349	R:R:L454	R:R:R505	2.43	No	Yes	1	9	9
350	R:R:L454	R:R:V526	2.98	No	Yes	1	9	8
351	R:R:K666	R:R:L455	2.82	Yes	No	0	9	7
352	R:R:M527	R:R:T457	3.01	No	No	0	7	6
353	R:R:I458	R:R:T498	3.04	No	No	0	9	9
354	R:R:G461	R:R:T494	3.64	No	No	0	9	7
355	R:R:G461	R:R:V495	1.84	No	Yes	0	9	8
356	R:R:S462	R:R:V495	6.46	No	Yes	0	9	8
357	R:R:S462	R:R:V655	3.23	No	Yes	0	9	7
358	R:R:I659	R:R:S462	3.1	No	No	0	7	9
359	R:R:G491	R:R:L464	3.42	No	No	0	9	8
360	R:R:L465	R:R:R488	4.86	Yes	Yes	0	9	9
361	R:R:G491	R:R:L465	3.42	No	Yes	0	9	9
362	R:R:L465	R:R:V495	2.98	Yes	Yes	0	9	8
363	R:R:L465	R:R:V655	4.47	Yes	Yes	0	9	7
364	R:R:T651	R:R:Y466	2.5	No	Yes	9	8	8
365	R:R:V655	R:R:Y466	6.31	Yes	Yes	9	7	8
366	R:R:T656	R:R:Y466	6.24	No	Yes	0	9	8
367	R:R:F467	R:R:V470	2.62	Yes	No	0	7	7
368	R:R:F467	R:R:I471	2.51	Yes	No	0	7	9
369	R:R:P468	R:R:V469	3.53	No	No	0	8	9
370	R:R:P468	R:R:Y647	2.78	No	Yes	0	8	5
371	R:R:I471	R:R:R480	2.51	No	No	0	9	9
372	R:R:I471	R:R:L483	4.28	No	No	0	9	7
373	R:R:L472	R:R:L644	4.15	No	No	0	7	9
374	R:R:L472	R:R:Y647	8.21	No	Yes	0	7	5
375	R:R:F474	R:R:Y473	9.28	No	Yes	0	8	8
376	R:R:F474	R:R:R480	2.14	No	No	0	8	9
377	R:R:E475	R:R:P476	12.58	No	No	0	5	9
378	R:R:E475	R:R:N571	3.94	No	No	0	5	5
379	R:R:C573	R:R:P476	1.88	No	No	0	9	9
380	R:R:R480	R:R:S477	7.91	No	No	0	9	9
381	R:R:C481	R:R:C573	5.46	No	No	0	9	9
382	R:R:I482	R:R:W486	2.35	Yes	Yes	1	7	9
383	R:R:I482	R:R:W544	3.52	Yes	Yes	1	7	9
384	R:R:I482	R:R:V548	3.07	Yes	Yes	1	7	6
385	R:R:I482	R:R:L558	2.85	Yes	No	1	7	6
386	R:R:R485	R:R:W544	10	No	Yes	0	9	9
387	R:R:D579	R:R:R485	13.1	No	No	0	9	9
388	R:R:L490	R:R:W486	2.28	No	Yes	1	8	9
389	R:R:F538	R:R:W486	2	No	Yes	1	4	9
390	R:R:L541	R:R:W486	15.94	Yes	Yes	1	9	9
391	R:R:T545	R:R:W486	9.7	No	Yes	0	9	9
392	R:R:F492	R:R:R488	3.21	Yes	Yes	1	9	9
393	R:R:E586	R:R:R488	4.65	Yes	Yes	1	9	9
394	R:R:H650	R:R:R488	3.39	Yes	Yes	0	9	9
395	R:R:F540	R:R:L489	2.44	Yes	No	0	9	7
396	R:R:L489	R:R:L541	6.92	No	Yes	0	7	9
397	R:R:F538	R:R:L490	7.31	No	No	1	4	8
398	R:R:L490	R:R:L541	4.15	No	Yes	1	8	9
399	R:R:G491	R:R:T494	1.82	No	No	0	9	7
400	R:R:F492	R:R:Y496	8.25	Yes	Yes	1	9	9
401	R:R:E586	R:R:F492	16.32	Yes	Yes	1	9	9
402	R:R:F492	R:R:L590	3.65	Yes	No	1	9	9
403	R:R:E620	R:R:F492	5.83	Yes	Yes	1	9	9
404	R:R:F492	W:W:?1	3.84	Yes	Yes	1	9	0
405	R:R:V495	R:R:Y496	5.05	Yes	Yes	0	8	9
406	R:R:E620	R:R:Y496	19.08	Yes	Yes	1	9	9
407	R:R:T658	R:R:Y496	11.24	No	Yes	0	9	9
408	R:R:G497	R:R:T500	1.82	No	Yes	0	9	7
409	R:R:K502	R:R:T498	3	Yes	No	0	9	9
410	R:R:M613	R:R:V499	4.56	Yes	No	0	7	7
411	R:R:F589	R:R:T500	3.89	No	Yes	1	8	7
412	R:R:T500	R:R:W592	3.64	Yes	Yes	1	7	9
413	R:R:G593	R:R:T500	1.82	No	Yes	0	7	7
414	R:R:L501	R:R:V526	2.98	No	Yes	0	9	8
415	R:R:L501	R:R:M529	2.83	No	No	0	9	7
416	R:R:L501	R:R:L530	2.77	No	No	0	9	9
417	R:R:E609	R:R:K502	4.05	Yes	Yes	1	9	9
418	R:R:K502	R:R:M613	2.88	Yes	Yes	1	9	7
419	R:R:L503	R:R:L596	4.15	No	Yes	0	8	9
420	R:R:C597	R:R:L503	3.17	No	No	0	8	8
421	R:R:L503	R:R:V600	2.98	No	Yes	0	8	9
422	R:R:H504	R:R:K508	15.72	Yes	Yes	1	9	8
423	R:R:H504	R:R:Y520	2.18	Yes	Yes	1	9	8
424	R:R:H504	R:R:W592	3.17	Yes	Yes	1	9	9
425	R:R:H504	R:R:L596	3.86	Yes	Yes	1	9	9
426	R:R:H504	X:X:?2	6.98	Yes	Yes	1	9	0
427	R:R:R505	R:R:Y520	6.17	Yes	Yes	1	9	8
428	R:R:R505	R:R:T522	3.88	Yes	No	0	9	8
429	R:R:R505	R:R:V526	2.62	Yes	Yes	1	9	8
430	R:R:A599	R:R:L507	3.15	No	No	0	9	9
431	R:R:L507	R:R:V600	4.47	No	Yes	0	9	9
432	R:R:K508	R:R:Y520	2.39	Yes	Yes	1	8	8
433	R:R:K508	X:X:?2	5.1	Yes	Yes	1	8	0
434	R:R:R513	R:R:V509	2.62	No	No	1	8	8
435	R:R:I518	R:R:V509	3.07	Yes	No	1	7	8
436	R:R:F510	R:R:V603	13.11	No	No	0	9	9
437	R:R:R513	R:R:S512	2.64	No	No	1	8	9
438	R:R:I518	R:R:S512	3.1	Yes	No	1	7	9
439	R:R:P519	R:R:S512	7.13	No	No	1	9	9
440	R:R:I518	R:R:R513	13.78	Yes	No	1	7	8
441	R:R:Q516	S:S:R517	7.01	No	No	0	9	9
442	R:R:P519	R:R:R517	11.53	No	No	0	9	9
443	R:R:R517	S:S:I518	11.27	No	No	0	9	7
444	R:R:I518	R:R:P519	3.39	Yes	No	1	7	9
445	R:R:R525	R:R:Y520	4.12	No	Yes	0	6	8
446	R:R:V526	R:R:Y520	10.09	Yes	Yes	1	8	8
447	R:R:M529	R:R:Y520	3.59	No	Yes	0	7	8
448	R:R:M521	R:R:T522	4.52	No	No	0	8	8
449	R:R:G523	R:R:T522	3.64	Yes	No	0	8	8
450	R:R:G523	R:R:G524	2.11	Yes	No	27	8	5
451	R:R:R525	R:R:R528	15.99	No	No	0	6	6
452	R:R:R525	W:W:?1	4.59	No	Yes	0	6	0
453	R:R:M529	W:W:?1	8.91	No	Yes	0	7	0
454	R:R:L530	R:R:L534	4.15	No	No	0	9	6
455	R:R:V532	W:W:?1	4.69	No	Yes	0	7	0
456	R:R:I533	W:W:?1	4.5	No	Yes	0	8	0
457	R:R:L535	W:W:?1	2.62	No	Yes	0	9	0
458	R:R:V536	W:W:?1	8.45	No	Yes	0	7	0
459	R:R:L541	R:R:V537	2.98	Yes	No	0	9	9
460	R:R:V537	W:W:?1	1.88	No	Yes	0	9	0
461	R:R:W539	S:S:W578	2.81	Yes	Yes	1	9	9
462	R:R:W539	S:S:M581	10.47	Yes	Yes	1	9	9
463	R:R:W539	S:S:T582	2.43	Yes	No	0	9	8
464	R:R:W539	S:S:A585	3.89	Yes	No	1	9	9
465	R:R:W539	W:W:?1	12.92	Yes	Yes	1	9	0
466	R:R:F540	R:R:W578	6.01	Yes	Yes	0	9	9
467	R:R:F540	R:R:T582	2.59	Yes	No	0	9	8
468	R:R:F540	X:X:?2	4.41	Yes	Yes	0	9	0
469	R:R:I542	S:S:M581	4.37	No	Yes	0	5	9
470	R:R:G543	S:S:W578	4.22	No	Yes	1	8	9
471	R:R:G543	S:S:M581	3.49	No	Yes	1	8	9
472	R:R:T545	R:R:W544	3.64	No	Yes	0	9	9
473	R:R:V548	R:R:W544	8.58	Yes	Yes	1	6	9
474	R:R:D576	R:R:W544	7.82	No	Yes	1	8	9
475	R:R:W544	R:R:W578	5.62	Yes	Yes	1	9	9
476	R:R:S547	S:S:W578	6.18	No	Yes	0	8	9
477	R:R:L558	R:R:V548	4.47	No	Yes	1	6	6
478	R:R:D576	R:R:V548	4.38	No	Yes	1	8	6
479	R:R:N551	R:R:Q550	3.96	No	No	0	7	8
480	R:R:K554	R:R:Q550	4.07	No	No	0	6	8
481	R:R:Q550	S:S:R577	10.51	No	No	0	8	8
482	R:R:N551	R:R:Q555	2.64	No	No	0	7	5
483	R:R:I556	R:R:L552	2.85	No	No	0	5	4
484	R:R:E553	R:R:K554	2.7	No	No	0	4	6
485	R:R:Q555	R:R:S557	8.66	No	No	0	5	6
486	R:R:Q555	S:S:K554	13.56	No	No	0	5	6
487	R:R:I556	R:R:I559	4.42	No	No	0	5	8
488	R:R:D576	R:R:L558	4.07	No	No	1	8	6
489	R:R:I569	R:R:Q561	5.49	No	No	0	5	5
490	R:R:I569	R:R:K563	10.18	No	No	0	5	4
491	R:R:F570	R:R:M572	7.46	No	No	0	9	6
492	R:R:D579	R:R:I575	7	No	No	1	9	6
493	R:R:I575	R:R:Y580	3.63	No	No	1	6	8
494	R:R:F632	R:R:I575	2.51	Yes	No	1	9	6
495	R:R:R577	S:S:Q550	16.35	No	No	0	8	8
496	R:R:M581	R:R:W578	4.65	Yes	Yes	1	9	9
497	R:R:W578	S:S:W539	1.87	Yes	Yes	1	9	9
498	R:R:W578	S:S:F540	4.01	Yes	Yes	1	9	9
499	R:R:W578	S:S:G543	4.22	Yes	No	1	9	8
500	R:R:W578	S:S:S547	4.94	Yes	No	0	9	8
501	R:R:W578	S:S:W578	1.87	Yes	Yes	1	9	9
502	R:R:D579	R:R:F632	2.39	No	Yes	1	9	9
503	R:R:F632	R:R:Y580	5.16	Yes	No	1	9	8
504	R:R:M581	S:S:W539	8.14	Yes	Yes	1	9	9
505	R:R:M581	S:S:I542	4.37	Yes	Yes	1	9	5
506	R:R:M581	S:S:G543	5.24	Yes	No	1	9	8
507	R:R:T582	S:S:W539	2.43	No	Yes	0	8	9
508	R:R:A583	R:R:H628	4.39	No	Yes	0	8	8
509	R:R:L588	R:R:V584	4.47	No	No	0	8	6
510	R:R:A585	S:S:W539	3.89	No	Yes	1	9	9
511	R:R:A585	X:X:?2	2.85	No	Yes	1	9	0
512	R:R:E586	R:R:H628	6.15	Yes	Yes	1	9	8
513	R:R:E586	W:W:?1	4.17	Yes	Yes	1	9	0
514	R:R:F587	R:R:L591	2.44	No	No	0	5	7
515	R:R:F587	R:R:L621	4.87	No	No	0	5	7
516	R:R:L588	X:X:?2	2.51	No	Yes	0	8	0
517	R:R:F589	R:R:W592	4.01	No	Yes	1	8	9
518	R:R:F589	W:W:?1	3.07	No	Yes	1	8	0
519	R:R:E620	R:R:L590	5.3	Yes	No	1	9	9
520	R:R:L590	R:R:L621	8.3	No	No	0	9	7
521	R:R:L596	R:R:W592	11.39	Yes	Yes	1	9	9
522	R:R:W592	X:X:?2	11.68	Yes	Yes	1	9	0
523	R:R:H618	R:R:V594	6.92	No	No	0	9	9
524	R:R:L596	R:R:Y595	2.34	Yes	No	0	9	8
525	R:R:A614	R:R:C597	3.61	No	No	0	8	8
526	R:R:C597	R:R:H618	2.95	No	No	0	8	9
527	R:R:R601	R:R:Y598	2.06	No	No	0	9	7
528	R:R:V600	R:R:V603	3.21	Yes	No	0	9	9
529	R:R:P610	R:R:S605	5.34	No	No	0	9	9
530	R:R:A606	R:R:F607	2.77	No	No	0	9	8
531	R:R:H608	R:R:R611	6.77	No	No	0	9	9
532	R:R:E609	R:R:P610	3.14	Yes	No	0	9	9
533	R:R:E609	R:R:M613	5.41	Yes	Yes	1	9	7
534	R:R:E609	R:R:K666	5.4	Yes	Yes	1	9	9
535	R:R:R611	R:R:Y612	3.09	No	No	0	9	9
536	R:R:L661	R:R:Y612	2.34	No	No	0	8	9
537	R:R:P665	R:R:Y612	8.34	No	No	0	9	9
538	R:R:L662	R:R:M613	5.65	No	Yes	0	8	7
539	R:R:I623	R:R:N619	5.66	No	No	0	5	9
540	R:R:N619	R:R:V657	4.43	No	No	0	9	7
541	R:R:E620	R:R:S624	5.75	Yes	No	0	9	9
542	R:R:E620	R:R:T654	4.23	Yes	Yes	0	9	9
543	R:R:I623	R:R:T654	3.04	No	Yes	0	5	9
544	R:R:H628	R:R:S624	4.18	Yes	No	0	8	9
545	R:R:H650	R:R:S624	2.79	Yes	No	0	9	9
546	R:R:I626	R:R:I630	2.94	No	No	0	5	5
547	R:R:F627	R:R:H628	4.53	Yes	Yes	1	9	8
548	R:R:F627	R:R:R631	5.34	Yes	Yes	1	9	9
549	R:R:F627	R:R:L646	6.09	Yes	No	0	9	8
550	R:R:F627	R:R:Y647	6.19	Yes	Yes	1	9	5
551	R:R:F627	R:R:H650	31.68	Yes	Yes	0	9	9
552	R:R:H628	R:R:R631	6.77	Yes	Yes	1	8	9
553	R:R:F632	R:R:H628	5.66	Yes	Yes	1	9	8
554	R:R:F632	R:R:R631	7.48	Yes	Yes	1	9	9
555	R:R:R631	R:R:Y647	6.17	Yes	Yes	1	9	5
556	R:R:L634	R:R:V633	2.98	No	No	0	5	4
557	R:R:L634	R:R:L638	2.77	No	No	0	5	8
558	R:R:L638	R:R:W642	2.28	No	No	0	8	7
559	R:R:D641	R:R:Q639	5.22	No	Yes	0	9	9
560	R:R:Q639	R:R:W642	6.57	Yes	No	0	9	7
561	R:R:M643	R:R:Y647	3.59	No	Yes	0	8	5
562	R:R:F648	R:R:H652	12.44	Yes	Yes	9	9	9
563	R:R:H650	R:R:T654	5.48	Yes	Yes	0	9	9
564	R:R:H652	R:R:T651	4.11	Yes	No	9	9	8
565	R:R:T651	R:R:V655	3.17	No	Yes	9	8	7
566	R:R:H652	R:R:T656	6.85	Yes	No	0	9	9
567	R:R:T654	R:R:V655	3.17	Yes	Yes	0	9	7
568	R:R:F667	R:R:L663	3.65	Yes	No	0	8	8
569	R:R:I664	R:R:P665	5.08	No	No	0	5	9
570	S:S:I69	S:S:T68	3.04	No	No	0	4	1
571	S:S:I69	S:S:K73	5.82	No	No	0	4	4
572	S:S:A71	S:S:K329	3.21	No	Yes	0	5	5
573	S:S:K73	S:S:Q72	5.42	No	No	28	4	4
574	S:S:E76	S:S:Q72	6.37	No	No	28	4	4
575	S:S:E76	S:S:K73	2.7	No	No	28	4	4
576	S:S:E77	S:S:L74	2.65	No	No	0	5	4
577	S:S:L105	S:S:L74	4.15	Yes	No	0	5	4
578	S:S:A75	S:S:V82	3.39	No	No	0	3	7
579	S:S:D81	S:S:V78	10.22	No	No	0	6	5
580	S:S:E104	S:S:V78	8.56	No	No	0	7	5
581	S:S:D81	S:S:Y85	2.3	No	Yes	0	6	8
582	S:S:D81	S:S:S100	4.42	No	No	0	6	7
583	S:S:A83	S:S:D90	3.09	No	No	0	7	7
584	S:S:D90	S:S:S84	10.31	No	No	0	7	6
585	S:S:S84	S:S:W281	6.18	No	Yes	0	6	9
586	S:S:E104	S:S:Y85	6.73	No	Yes	0	7	8
587	S:S:W281	S:S:Y85	5.79	Yes	Yes	0	9	8
588	S:S:K355	S:S:Y85	5.97	No	Yes	0	6	8
589	S:S:E387	S:S:L86	6.63	No	No	0	4	8
590	S:S:G89	S:S:Y87	10.14	Yes	No	0	7	6
591	S:S:G89	S:S:T88	1.82	Yes	No	0	7	7
592	S:S:K278	S:S:S91	6.12	No	No	0	5	4
593	S:S:L94	S:S:Q93	3.99	No	No	0	9	4
594	S:S:N274	S:S:R96	6.03	No	No	0	5	3
595	S:S:C272	S:S:C99	7.28	No	No	29	9	9
596	S:S:G101	S:S:S100	1.86	No	No	0	4	7
597	S:S:L270	S:S:S100	3	No	No	0	9	7
598	S:S:E104	S:S:G101	3.27	No	No	0	7	4
599	S:S:R102	S:S:Y269	12.35	No	No	0	5	5
600	S:S:A106	S:S:Y103	8.01	No	No	0	3	5
601	S:S:P267	S:S:Y103	8.34	No	No	0	5	5
602	S:S:L105	S:S:L108	5.54	Yes	No	10	5	4
603	S:S:F324	S:S:L105	17.05	No	Yes	0	9	5
604	S:S:K329	S:S:L105	9.87	Yes	Yes	10	5	5
605	S:S:A106	S:S:G107	1.95	No	No	0	3	5
606	S:S:G107	S:S:P109	2.03	No	No	0	5	4
607	S:S:G107	S:S:W112	2.81	No	Yes	0	5	4
608	S:S:L108	S:S:P109	4.93	No	No	0	4	4
609	S:S:K329	S:S:L108	8.46	Yes	No	10	5	4
610	S:S:D321	S:S:P109	8.05	No	No	0	5	4
611	S:S:K111	S:S:W112	18.57	No	Yes	0	3	4
612	S:S:K111	S:S:W265	4.64	No	Yes	0	3	7
613	S:S:W112	S:S:W323	23.43	Yes	Yes	0	4	9
614	S:S:A116	S:S:G322	1.95	No	No	0	7	5
615	S:S:A116	S:S:W323	2.59	No	Yes	0	7	9
616	S:S:A118	S:S:W323	7.78	No	Yes	0	4	9
617	S:S:H119	S:S:P120	3.05	No	No	0	4	3
618	S:S:H119	S:S:V313	11.07	No	No	0	4	6
619	S:S:D314	S:S:H119	3.78	No	No	0	8	4
620	S:S:L122	S:S:W265	3.42	No	Yes	0	7	7
621	S:S:I308	S:S:L122	2.85	Yes	No	0	6	7
622	S:S:L122	S:S:W323	5.69	No	Yes	0	7	9
623	S:S:E168	S:S:R124	11.63	Yes	No	0	8	5
624	S:S:P169	S:S:R124	5.76	No	No	0	4	5
625	S:S:A125	S:S:I308	3.25	No	Yes	0	7	6
626	S:S:L126	S:S:T130	2.95	Yes	No	12	4	4
627	S:S:F263	S:S:L126	3.65	Yes	Yes	12	6	4
628	S:S:L126	S:S:L285	2.77	Yes	Yes	0	4	9
629	S:S:D127	S:S:H131	7.56	No	No	0	5	7
630	S:S:H131	S:S:T128	4.11	No	No	7	7	8
631	S:S:E168	S:S:T128	8.47	Yes	No	0	8	8
632	S:S:L129	S:S:L285	2.77	Yes	Yes	0	6	9
633	S:S:L129	S:S:S287	3	Yes	No	0	6	7
634	S:S:L129	S:S:M304	2.83	Yes	No	0	6	7
635	S:S:L129	S:S:V306	4.47	Yes	No	0	6	7
636	S:S:F263	S:S:T130	9.08	Yes	No	12	6	4
637	S:S:N137	S:S:T133	5.85	No	Yes	0	9	8
638	S:S:F263	S:S:T133	2.59	Yes	Yes	12	6	8
639	S:S:S287	S:S:T133	4.8	No	Yes	12	7	8
640	S:S:M304	S:S:T133	3.01	No	Yes	0	7	8
641	S:S:N134	S:S:V138	2.96	No	Yes	16	9	6
642	S:S:F135	S:S:L160	2.44	Yes	Yes	11	8	9
643	S:S:L136	S:S:Y157	2.34	No	Yes	0	9	9
644	S:S:N137	S:S:Y290	11.63	No	No	0	9	8
645	S:S:L140	S:S:Y290	2.34	No	No	0	8	8
646	S:S:L140	S:S:L292	6.92	No	No	0	8	9
647	S:S:K144	S:S:R146	7.43	No	Yes	5	7	8
648	S:S:E147	S:S:S145	2.87	Yes	No	0	9	9
649	S:S:Q148	S:S:R146	4.67	No	Yes	0	6	8
650	S:S:E147	S:S:N149	3.94	Yes	No	0	9	7
651	S:S:E147	S:S:Y157	8.98	Yes	Yes	22	9	9
652	S:S:E147	S:S:F178	2.33	Yes	No	22	9	6
653	S:S:L150	S:S:Q148	3.99	No	No	0	5	6
654	S:S:L154	S:S:N149	5.49	No	No	0	5	7
655	S:S:D153	S:S:L150	4.07	No	No	0	9	5
656	S:S:D152	S:S:Q151	7.83	No	No	21	6	5
657	S:S:F191	S:S:L154	2.44	Yes	No	0	8	5
658	S:S:D155	S:S:Q158	6.53	No	No	0	7	8
659	S:S:F178	S:S:Y157	16.5	No	Yes	22	6	9
660	S:S:F191	S:S:Y157	2.06	Yes	Yes	0	8	9
661	S:S:F191	S:S:Q158	2.34	Yes	No	0	8	8
662	S:S:I201	S:S:Q158	12.35	No	No	0	9	8
663	S:S:L160	S:S:S163	4.5	Yes	No	11	9	8
664	S:S:I176	S:S:V161	4.61	No	No	0	7	9
665	S:S:Q193	S:S:V161	11.46	Yes	No	0	8	9
666	S:S:E166	S:S:W162	4.36	No	Yes	0	8	7
667	S:S:Q193	S:S:W162	6.57	Yes	Yes	15	8	7
668	S:S:S199	S:S:W162	4.94	Yes	Yes	15	3	7
669	S:S:I171	S:S:L165	7.14	Yes	No	0	8	6
670	S:S:L165	S:S:Q193	5.32	No	Yes	15	6	8
671	S:S:L165	S:S:S199	3	No	Yes	15	6	3
672	S:S:E168	S:S:G167	4.91	Yes	No	0	8	7
673	S:S:E168	S:S:I171	4.1	Yes	Yes	0	8	8
674	S:S:I171	S:S:R196	2.51	Yes	No	0	8	8
675	S:S:I171	S:S:V306	3.07	Yes	No	0	8	7
676	S:S:R173	S:S:S172	2.64	No	No	0	7	5
677	S:S:S172	S:S:T195	3.2	No	No	0	5	8
678	S:S:D307	S:S:S172	2.94	No	No	0	9	5
679	S:S:L192	S:S:R173	7.29	No	No	0	9	7
680	S:S:F191	S:S:I176	7.54	Yes	No	0	8	7
681	S:S:G302	S:S:T177	3.64	No	No	0	9	8
682	S:S:K305	S:S:T177	3	Yes	No	0	8	8
683	S:S:F178	S:S:F300	6.43	No	Yes	0	6	8
684	S:S:A187	S:S:P188	1.87	No	No	0	4	8
685	S:S:A187	S:S:Q189	4.55	No	No	0	4	6
686	S:S:Q204	S:S:V190	12.89	No	No	0	8	7
687	S:S:F191	S:S:L203	3.65	Yes	No	0	8	9
688	S:S:L192	S:S:L202	5.54	No	No	0	9	4
689	S:S:L192	S:S:Q204	3.99	No	No	0	9	8
690	S:S:Q193	S:S:S199	10.11	Yes	Yes	15	8	3
691	S:S:E197	S:S:R196	2.33	No	No	0	3	8
692	S:S:E198	S:S:R200	4.65	No	No	0	4	5
693	S:S:A288	S:S:S261	3.42	No	No	0	7	4
694	S:S:F263	S:S:S287	5.28	Yes	No	12	6	7
695	S:S:K264	S:S:S286	3.06	No	No	0	4	9
696	S:S:V283	S:S:W265	3.68	No	Yes	0	6	7
697	S:S:L285	S:S:W265	12.53	Yes	Yes	0	9	7
698	S:S:P267	S:S:S266	3.56	No	No	0	5	8
699	S:S:S266	S:S:T284	4.8	No	No	0	8	8
700	S:S:P267	S:S:P268	1.95	No	No	0	5	9
701	S:S:P268	S:S:W281	4.05	No	Yes	0	9	9
702	S:S:T284	S:S:Y269	4.99	No	No	0	8	5
703	S:S:L270	S:S:P279	3.28	No	No	0	9	9
704	S:S:E271	S:S:E273	3.81	No	No	0	8	5
705	S:S:E273	S:S:N274	2.63	No	No	0	5	5
706	S:S:E273	S:S:Y277	21.32	No	No	0	5	8
707	S:S:G280	S:S:P279	2.03	No	No	0	3	9
708	S:S:G280	S:S:W281	5.63	No	Yes	0	3	9
709	S:S:F358	S:S:W281	9.02	No	Yes	0	7	9
710	S:S:D307	S:S:L282	4.07	No	No	0	9	7
711	S:S:I308	S:S:V283	6.14	Yes	No	0	6	6
712	S:S:D307	S:S:T284	5.78	No	No	0	9	8
713	S:S:I308	S:S:L285	2.85	Yes	Yes	0	6	9
714	S:S:S286	S:S:V303	3.23	No	No	31	9	9
715	S:S:K305	S:S:S286	3.06	Yes	No	31	8	9
716	S:S:F300	S:S:I289	5.02	Yes	No	0	8	8
717	S:S:E299	S:S:Y290	2.24	No	No	0	8	8
718	S:S:P298	S:S:Q293	6.32	No	No	0	9	7
719	S:S:E299	S:S:R301	2.33	No	No	0	8	8
720	S:S:F300	S:S:G302	3.01	Yes	No	0	8	9
721	S:S:K305	S:S:V303	7.59	Yes	No	31	8	9
722	S:S:L310	S:S:V313	7.45	No	No	0	8	6
723	S:S:L310	S:S:W323	5.69	No	Yes	0	8	9
724	S:S:F358	S:S:L310	8.53	No	No	0	7	8
725	S:S:K312	S:S:Q311	8.14	No	No	0	5	9
726	S:S:Q311	S:S:Y359	2.25	No	No	0	9	9
727	S:S:D314	S:S:P361	9.66	No	Yes	30	8	5
728	S:S:D314	S:S:V363	8.76	No	No	30	8	2
729	S:S:F358	S:S:I315	10.05	No	No	0	7	8
730	S:S:D316	S:S:Q317	11.75	Yes	No	0	8	9
731	S:S:D316	S:S:G322	3.35	Yes	No	0	8	5
732	S:S:D316	S:S:W323	2.23	Yes	Yes	0	8	9
733	S:S:D316	S:S:S325	5.89	Yes	Yes	0	8	7
734	S:S:Q317	S:S:S320	10.11	No	No	0	9	4
735	S:S:C318	S:S:S325	3.44	No	Yes	10	9	7
736	S:S:C318	S:S:Y350	14.79	No	Yes	10	9	9
737	S:S:C318	S:S:C354	7.28	No	No	10	9	9
738	S:S:S319	S:S:S320	3.26	No	No	0	7	4
739	S:S:E351	S:S:S319	14.37	No	No	0	4	7
740	S:S:D321	S:S:T327	7.23	No	No	0	5	9
741	S:S:F324	S:S:K355	2.48	No	No	0	9	6
742	S:S:K329	S:S:S325	4.59	Yes	Yes	10	5	7
743	S:S:C354	S:S:S325	5.16	No	Yes	10	9	7
744	S:S:G326	S:S:T327	3.64	No	No	0	6	9
745	S:S:H328	S:S:T327	6.85	No	No	0	9	9
746	S:S:C330	S:S:N333	6.3	No	Yes	3	9	9
747	S:S:C330	S:S:C352	7.28	No	No	3	9	9
748	S:S:H331	S:S:Y390	4.36	No	Yes	0	8	5
749	S:S:L332	S:S:S335	4.5	No	No	0	6	8
750	S:S:E336	S:S:L332	9.28	No	No	0	6	6
751	S:S:L332	S:S:Y390	5.86	No	Yes	0	6	5
752	S:S:N333	S:S:V346	8.87	Yes	No	3	9	7
753	S:S:E351	S:S:N333	15.77	No	Yes	0	4	9
754	S:S:C352	S:S:N333	7.87	No	Yes	3	9	9
755	S:S:N333	S:S:R370	2.41	Yes	Yes	3	9	1
756	S:S:M338	S:S:N334	14.02	No	No	3	3	7
757	S:S:N334	S:S:P339	4.89	No	No	3	7	8
758	S:S:C337	S:S:K341	8.08	Yes	Yes	3	9	3
759	S:S:C337	S:S:R370	9.75	Yes	Yes	3	9	1
760	S:S:C337	S:S:H377	10.32	Yes	Yes	3	9	3
761	S:S:C337	S:S:C392	7.28	Yes	No	3	9	9
762	S:S:M338	S:S:P339	3.35	No	No	3	3	8
763	S:S:G344	S:S:M338	3.49	Yes	No	3	9	3
764	S:S:I340	S:S:Q376	6.86	No	Yes	3	5	3
765	S:S:H377	S:S:I340	14.58	Yes	No	3	3	5
766	S:S:G344	S:S:K341	3.49	Yes	Yes	3	9	3
767	S:S:K341	S:S:R370	16.09	Yes	Yes	3	3	1
768	S:S:K341	S:S:R372	13.61	Yes	Yes	3	3	1
769	S:S:H377	S:S:K341	6.55	Yes	Yes	3	3	3
770	S:S:G342	S:S:R372	4.5	No	Yes	0	6	1
771	S:S:F345	S:S:L343	10.96	No	No	0	9	4
772	S:S:F345	S:S:G344	3.01	No	Yes	0	9	9
773	S:S:G344	S:S:R370	3	Yes	Yes	3	9	1
774	S:S:G344	S:S:R372	3	Yes	Yes	3	9	1
775	S:S:R370	S:S:V346	20.92	Yes	No	3	1	7
776	S:S:G348	S:S:L347	5.13	No	No	0	9	9
777	S:S:E351	S:S:L347	15.9	No	No	0	4	9
778	S:S:F369	S:S:G348	9.03	No	No	0	1	9
779	S:S:I353	S:S:Y350	9.67	No	Yes	10	4	9
780	S:S:C354	S:S:Y350	6.72	No	Yes	10	9	9
781	S:S:P365	S:S:Y350	9.74	Yes	Yes	10	3	9
782	S:S:I353	S:S:P365	6.77	No	Yes	10	4	3
783	S:S:I353	S:S:N367	21.24	No	No	0	4	5
784	S:S:A356	S:S:G357	1.95	No	No	0	3	9
785	S:S:P361	S:S:Y359	2.78	Yes	No	0	5	9
786	S:S:H360	S:S:P365	9.15	No	Yes	0	6	3
787	S:S:G362	S:S:P361	2.03	No	Yes	0	3	5
788	S:S:P361	S:S:V363	5.3	Yes	No	30	5	2
789	S:S:F369	S:S:V366	15.73	No	No	0	1	4
790	S:S:N368	S:S:S379	4.47	No	Yes	3	4	3
791	S:S:G380	S:S:N368	5.09	No	No	3	3	4
792	S:S:C392	S:S:R370	4.18	No	Yes	3	9	1
793	S:S:R371	S:S:S379	10.54	No	Yes	0	1	3
794	S:S:G373	S:S:R372	4.5	No	Yes	3	1	1
795	S:S:P374	S:S:R372	10.09	Yes	Yes	3	1	1
796	S:S:D375	S:S:R372	8.34	No	Yes	3	1	1
797	S:S:G373	S:S:P374	4.06	No	Yes	3	1	1
798	S:S:D375	S:S:P374	3.22	No	Yes	3	1	1
799	S:S:P374	S:S:P400	5.84	Yes	No	0	1	3
800	S:S:H377	S:S:Q376	3.71	Yes	Yes	3	3	3
801	S:S:L393	S:S:Q376	17.3	No	Yes	3	6	3
802	S:S:Q376	S:S:R396	16.35	Yes	No	0	3	5
803	S:S:H377	S:S:L393	19.28	Yes	No	3	3	6
804	S:S:I378	S:S:P394	8.47	No	No	0	1	9
805	S:S:C395	S:S:I378	8.18	No	No	0	9	1
806	S:S:G380	S:S:S379	1.86	No	Yes	3	3	3
807	S:S:C392	S:S:G380	1.96	No	No	3	9	3
808	S:S:P394	S:S:T382	5.25	No	No	0	9	4
809	S:S:D384	S:S:K383	15.21	Yes	No	13	1	8
810	S:S:K383	S:S:V391	6.07	No	No	13	8	3
811	S:S:D384	S:S:E388	7.8	Yes	No	13	1	3
812	S:S:D384	S:S:Y390	6.9	Yes	Yes	13	1	5
813	S:S:D384	S:S:V391	11.69	Yes	No	13	1	3
814	S:S:E387	S:S:S386	10.06	No	No	0	4	4
815	S:S:E388	S:S:Y390	32.55	No	Yes	13	3	5
816	S:S:L393	S:S:P394	3.28	No	No	0	6	9
817	S:S:C395	S:S:C402	7.28	No	No	0	9	9
818	S:S:C399	S:S:E397	3.04	Yes	No	18	9	6
819	S:S:D405	S:S:E397	2.6	No	No	0	7	6
820	S:S:E397	S:S:P407	12.58	No	Yes	18	6	9
821	S:S:C399	S:S:G398	1.96	Yes	No	0	9	8
822	S:S:F409	S:S:G398	3.01	No	No	0	3	8
823	S:S:C399	S:S:P400	1.88	Yes	No	0	9	3
824	S:S:C399	S:S:F401	4.19	Yes	No	18	9	4
825	S:S:C399	S:S:P407	1.88	Yes	Yes	18	9	9
826	S:S:C399	S:S:C408	1.82	Yes	No	0	9	9
827	S:S:F401	S:S:P407	4.33	No	Yes	18	4	9
828	S:S:D404	S:S:D405	7.98	No	No	0	8	7
829	S:S:D405	S:S:Q411	3.92	No	No	0	7	7
830	S:S:P407	S:S:S406	3.56	Yes	No	0	9	5
831	S:S:C408	S:S:I569	3.27	No	No	0	9	5
832	S:S:L568	S:S:V410	5.96	No	No	0	7	6
833	S:S:Q639	S:S:V410	2.87	Yes	No	0	9	6
834	S:S:E412	S:S:R417	11.63	No	Yes	0	7	9
835	S:S:D413	S:S:Y415	2.3	No	No	0	8	4
836	S:S:D413	S:S:L416	4.07	No	Yes	0	8	9
837	S:S:K414	S:S:L418	7.05	No	No	0	2	5
838	S:S:I420	S:S:L416	2.85	No	Yes	0	8	9
839	S:S:D641	S:S:L416	2.71	Yes	Yes	0	9	9
840	S:S:L416	S:S:M645	5.65	Yes	No	0	9	7
841	S:S:R417	S:S:Y473	10.29	Yes	No	0	9	8
842	S:S:D641	S:S:R417	3.57	Yes	Yes	32	9	9
843	S:S:L644	S:S:R417	6.07	No	Yes	32	9	9
844	S:S:F648	S:S:I420	5.02	Yes	No	0	9	8
845	S:S:I421	S:S:V470	3.07	No	No	0	7	7
846	S:S:I421	S:S:Y473	9.67	No	No	0	7	8
847	S:S:F423	S:S:L426	2.44	No	No	0	5	4
848	S:S:F423	S:S:F648	4.29	No	Yes	6	5	9
849	S:S:F423	S:S:H652	6.79	No	Yes	6	5	9
850	S:S:C427	S:S:Q424	3.05	No	Yes	6	8	9
851	S:S:Q424	S:S:Y466	4.51	Yes	Yes	6	9	8
852	S:S:Q424	S:S:V469	4.3	Yes	No	0	9	9
853	S:S:F648	S:S:Q424	3.51	Yes	Yes	6	9	9
854	S:S:Q424	S:S:T651	7.09	Yes	Yes	6	9	8
855	S:S:H652	S:S:Q424	11.13	Yes	Yes	6	9	9
856	S:S:C427	S:S:Y466	2.69	No	Yes	6	8	8
857	S:S:C427	S:S:H652	4.42	No	Yes	6	8	9
858	S:S:M428	S:S:Y466	8.38	No	Yes	0	7	8
859	S:S:F467	S:S:M428	6.22	Yes	No	0	7	7
860	S:S:D431	S:S:L459	6.79	Yes	No	0	6	9
861	S:S:D431	S:S:S462	4.42	Yes	Yes	6	6	9
862	S:S:D431	S:S:L463	6.79	Yes	No	0	6	8
863	S:S:D431	S:S:I659	2.8	Yes	No	6	6	7
864	S:S:F432	S:S:M435	2.49	No	Yes	0	7	9
865	S:S:L459	S:S:S434	6.01	No	No	0	9	8
866	S:S:L663	S:S:S434	6.01	No	No	0	8	8
867	S:S:L459	S:S:M435	4.24	No	Yes	0	9	9
868	S:S:F460	S:S:M435	3.73	No	Yes	0	5	9
869	S:S:L463	S:S:M435	2.83	No	Yes	0	8	9
870	S:S:F667	S:S:V437	3.93	Yes	No	0	8	4
871	S:S:E456	S:S:V438	5.7	No	No	0	9	7
872	S:S:F667	S:S:V438	2.62	Yes	No	0	8	7
873	S:S:R442	S:S:Y439	2.06	No	No	0	9	9
874	S:S:F441	S:S:H440	7.92	No	No	0	6	7
875	S:S:F441	S:S:F667	4.29	No	Yes	0	6	8
876	S:S:L452	S:S:R442	4.86	No	No	0	7	9
877	S:S:F607	S:S:K445	6.2	No	No	0	8	8
878	S:S:F607	S:S:S446	3.96	No	No	0	8	8
879	S:S:I447	S:S:L455	2.85	No	No	0	9	7
880	S:S:G451	S:S:S450	1.86	No	Yes	0	8	9
881	S:S:K502	S:S:S450	4.59	Yes	Yes	14	9	9
882	S:S:E609	S:S:S450	5.75	Yes	Yes	14	9	9
883	S:S:K666	S:S:S450	4.59	No	Yes	14	9	9
884	S:S:E456	S:S:L452	5.3	No	No	0	9	7
885	S:S:I453	S:S:M527	5.83	No	Yes	0	5	7
886	S:S:L454	S:S:V526	5.96	No	No	0	9	8
887	S:S:L454	S:S:M527	2.83	No	Yes	0	9	7
888	S:S:K666	S:S:L455	4.23	No	No	0	9	7
889	S:S:M527	S:S:T457	6.02	Yes	No	0	7	6
890	S:S:I458	S:S:T498	3.04	No	No	0	9	9
891	S:S:I458	S:S:V499	3.07	No	No	0	9	7
892	S:S:I458	S:S:L662	2.85	No	No	0	9	8
893	S:S:G461	S:S:T494	3.64	No	No	0	9	7
894	S:S:G461	S:S:V495	1.84	No	No	0	9	8
895	S:S:I659	S:S:S462	4.64	No	Yes	6	7	9
896	S:S:L465	S:S:R488	6.07	No	Yes	0	9	9
897	S:S:G491	S:S:L465	3.42	No	No	0	9	9
898	S:S:L465	S:S:V655	5.96	No	Yes	0	9	7
899	S:S:T651	S:S:Y466	2.5	Yes	Yes	6	8	8
900	S:S:V655	S:S:Y466	6.31	Yes	Yes	6	7	8
901	S:S:T656	S:S:Y466	6.24	No	Yes	0	9	8
902	S:S:F467	S:S:V470	2.62	Yes	No	0	7	7
903	S:S:F467	S:S:I471	2.51	Yes	No	0	7	9
904	S:S:P468	S:S:Y647	2.78	No	Yes	0	8	5
905	S:S:I471	S:S:L483	4.28	No	No	0	9	7
906	S:S:I471	S:S:L484	4.28	No	No	0	9	9
907	S:S:L472	S:S:Y647	7.03	No	Yes	0	7	5
908	S:S:F474	S:S:Y473	6.19	No	No	0	8	8
909	S:S:F474	S:S:R480	9.62	No	No	0	8	9
910	S:S:E475	S:S:P476	3.14	No	No	0	5	9
911	S:S:E475	S:S:R480	2.33	No	No	0	5	9
912	S:S:N571	S:S:P476	4.89	No	No	0	5	9
913	S:S:R480	S:S:S477	5.27	No	No	0	9	9
914	S:S:L558	S:S:T478	2.95	No	No	0	6	6
915	S:S:C481	S:S:R485	4.18	No	Yes	0	9	9
916	S:S:C481	S:S:C573	5.46	No	No	0	9	9
917	S:S:I482	S:S:W486	2.35	Yes	Yes	1	7	9
918	S:S:I482	S:S:T545	3.04	Yes	No	1	7	9
919	S:S:I482	S:S:V548	3.07	Yes	No	0	7	6
920	S:S:I482	S:S:L558	2.85	Yes	No	0	7	6
921	S:S:R485	S:S:W544	11	Yes	Yes	1	9	9
922	S:S:D576	S:S:R485	2.38	No	Yes	1	8	9
923	S:S:D579	S:S:R485	4.76	Yes	Yes	1	9	9
924	S:S:L490	S:S:W486	2.28	No	Yes	1	8	9
925	S:S:F538	S:S:W486	3.01	No	Yes	0	4	9
926	S:S:L541	S:S:W486	10.25	No	Yes	1	9	9
927	S:S:T545	S:S:W486	7.28	No	Yes	1	9	9
928	S:S:F492	S:S:R488	3.21	Yes	Yes	1	9	9
929	S:S:E586	S:S:R488	8.14	No	Yes	1	9	9
930	S:S:H650	S:S:R488	4.51	Yes	Yes	0	9	9
931	S:S:F540	S:S:L489	2.44	Yes	No	1	9	7
932	S:S:L489	S:S:L541	4.15	No	No	1	7	9
933	S:S:L489	W:W:?1	2.62	No	Yes	1	7	0
934	S:S:L490	S:S:L541	4.15	No	No	1	8	9
935	S:S:F492	S:S:Y496	12.38	Yes	Yes	1	9	9
936	S:S:E586	S:S:F492	10.49	No	Yes	1	9	9
937	S:S:F492	S:S:L590	4.87	Yes	No	1	9	9
938	S:S:E620	S:S:F492	4.66	Yes	Yes	1	9	9
939	S:S:F492	X:X:?2	2.2	Yes	Yes	1	9	0
940	S:S:L534	S:S:T494	2.95	No	No	0	6	7
941	S:S:V495	S:S:Y496	5.05	No	Yes	0	8	9
942	S:S:E620	S:S:Y496	23.57	Yes	Yes	1	9	9
943	S:S:T658	S:S:Y496	8.74	No	Yes	0	9	9
944	S:S:G497	S:S:T500	1.82	No	Yes	1	9	7
945	S:S:F589	S:S:G497	3.01	Yes	No	1	8	9
946	S:S:L530	S:S:T498	2.95	No	No	0	9	9
947	S:S:M613	S:S:V499	3.04	Yes	No	0	7	7
948	S:S:F589	S:S:T500	2.59	Yes	Yes	1	8	7
949	S:S:T500	S:S:W592	4.85	Yes	Yes	1	7	9
950	S:S:G593	S:S:T500	1.82	No	Yes	0	7	7
951	S:S:L501	S:S:V526	2.98	Yes	No	0	9	8
952	S:S:L501	S:S:M529	4.24	Yes	No	0	9	7
953	S:S:L501	S:S:L530	2.77	Yes	No	0	9	9
954	S:S:I533	S:S:L501	2.85	No	Yes	0	8	9
955	S:S:K502	S:S:R505	3.71	Yes	No	0	9	9
956	S:S:E609	S:S:K502	6.75	Yes	Yes	14	9	9
957	S:S:K502	S:S:M613	4.32	Yes	Yes	14	9	7
958	S:S:L503	S:S:L596	2.77	No	Yes	0	8	9
959	S:S:L503	S:S:M613	4.24	No	Yes	0	8	7
960	S:S:H504	S:S:K508	5.24	Yes	No	1	9	8
961	S:S:H504	S:S:W592	2.12	Yes	Yes	1	9	9
962	S:S:H504	S:S:L596	3.86	Yes	Yes	1	9	9
963	S:S:H504	W:W:?1	5.67	Yes	Yes	1	9	0
964	S:S:R505	S:S:Y520	6.17	No	Yes	0	9	8
965	S:S:V506	S:S:V600	4.81	No	No	33	9	9
966	S:S:P610	S:S:V506	3.53	No	No	0	9	9
967	S:S:A599	S:S:L507	4.73	No	No	0	9	9
968	S:S:K508	S:S:Y520	8.36	No	Yes	0	8	8
969	S:S:K508	W:W:?1	5.33	No	Yes	1	8	0
970	S:S:V509	S:S:Y520	2.52	No	Yes	0	8	8
971	S:S:F510	S:S:R513	6.41	No	No	0	9	8
972	S:S:F510	S:S:T514	5.19	No	No	0	9	8
973	S:S:F510	S:S:V603	6.55	No	Yes	0	9	9
974	S:S:I518	S:S:S512	4.64	No	No	0	7	9
975	S:S:R525	S:S:Y520	7.2	No	Yes	0	6	8
976	S:S:V526	S:S:Y520	3.79	No	Yes	0	8	8
977	S:S:G523	S:S:T522	1.82	No	No	0	8	8
978	S:S:G523	S:S:G524	2.11	No	No	0	8	5
979	S:S:G523	S:S:M527	3.49	No	Yes	0	8	7
980	S:S:R525	S:S:R528	4.26	No	No	0	6	6
981	S:S:M529	W:W:?1	3.56	No	Yes	1	7	0
982	S:S:M529	X:X:?2	9.38	No	Yes	1	7	0
983	S:S:L530	S:S:L534	4.15	No	No	0	9	6
984	S:S:V532	W:W:?1	1.88	No	Yes	1	7	0
985	S:S:V532	X:X:?2	4.49	No	Yes	1	7	0
986	S:S:F589	S:S:I533	2.51	Yes	No	1	8	8
987	S:S:I533	X:X:?2	3.44	No	Yes	1	8	0
988	S:S:L535	X:X:?2	2.51	No	Yes	0	9	0
989	S:S:V536	W:W:?1	1.88	No	Yes	1	7	0
990	S:S:V536	X:X:?2	5.39	No	Yes	1	7	0
991	S:S:V537	W:W:?1	1.88	No	Yes	0	9	0
992	S:S:F538	S:S:I542	10.05	No	Yes	0	4	5
993	S:S:W539	X:X:?2	11.68	Yes	Yes	1	9	0
994	S:S:F540	S:S:W544	3.01	Yes	Yes	1	9	9
995	S:S:F540	S:S:W578	9.02	Yes	Yes	1	9	9
996	S:S:F540	S:S:T582	2.59	Yes	No	0	9	8
997	S:S:F540	W:W:?1	3.84	Yes	Yes	1	9	0
998	S:S:G543	S:S:I542	3.53	No	Yes	1	8	5
999	S:S:T545	S:S:W544	3.64	No	Yes	1	9	9
1000	S:S:V548	S:S:W544	6.13	No	Yes	0	6	9
1001	S:S:D576	S:S:W544	7.82	No	Yes	1	8	9
1002	S:S:W544	S:S:W578	6.56	Yes	Yes	1	9	9
1003	S:S:N551	S:S:Q555	6.6	No	No	0	7	5
1004	S:S:I556	S:S:L552	4.28	No	No	0	5	4
1005	S:S:L574	S:S:S557	4.5	No	No	0	7	6
1006	S:S:G560	S:S:L574	5.13	No	No	0	3	7
1007	S:S:I569	S:S:Q561	8.23	No	No	0	5	5
1008	S:S:N571	S:S:Q561	2.64	No	No	0	5	5
1009	S:S:F570	S:S:G562	6.02	Yes	No	0	9	7
1010	S:S:H567	S:S:K563	9.17	No	No	0	7	4
1011	S:S:L568	S:S:T564	7.37	No	No	0	7	9
1012	S:S:F570	S:S:T564	2.59	Yes	No	0	9	9
1013	S:S:D566	S:S:L568	2.71	No	No	0	4	7
1014	S:S:F570	S:S:M572	3.73	Yes	No	0	9	6
1015	S:S:F570	S:S:Q639	2.34	Yes	Yes	0	9	9
1016	S:S:F570	S:S:S640	2.64	Yes	No	0	9	8
1017	S:S:D579	S:S:I575	5.6	Yes	No	1	9	6
1018	S:S:I575	S:S:Y580	7.25	No	No	1	6	8
1019	S:S:F632	S:S:I575	2.51	Yes	No	1	9	6
1020	S:S:D576	S:S:W578	5.58	No	Yes	1	8	9
1021	S:S:R577	S:S:Y580	4.12	No	No	0	8	8
1022	S:S:M581	S:S:W578	2.33	Yes	Yes	1	9	9
1023	S:S:D579	S:S:R631	3.57	Yes	Yes	1	9	9
1024	S:S:D579	S:S:F632	2.39	Yes	Yes	1	9	9
1025	S:S:F632	S:S:Y580	11.35	Yes	No	1	9	8
1026	S:S:A583	S:S:H628	4.39	No	Yes	1	8	8
1027	S:S:A583	S:S:F632	2.77	No	Yes	1	8	9
1028	S:S:L588	S:S:V584	2.98	No	No	0	8	6
1029	S:S:A585	W:W:?1	3.97	No	Yes	1	9	0
1030	S:S:E586	S:S:H628	2.46	No	Yes	1	9	8
1031	S:S:F587	S:S:L591	2.44	No	No	0	5	7
1032	S:S:F587	S:S:L621	7.31	No	No	0	5	7
1033	S:S:L588	W:W:?1	2.62	No	Yes	0	8	0
1034	S:S:F589	S:S:W592	5.01	Yes	Yes	1	8	9
1035	S:S:F589	W:W:?1	5.37	Yes	Yes	1	8	0
1036	S:S:F589	X:X:?2	2.2	Yes	Yes	1	8	0
1037	S:S:E620	S:S:L590	3.98	Yes	No	1	9	9
1038	S:S:L590	S:S:L621	4.15	No	No	0	9	7
1039	S:S:L596	S:S:W592	9.11	Yes	Yes	1	9	9
1040	S:S:W592	W:W:?1	10.76	Yes	Yes	1	9	0
1041	S:S:G593	S:S:V617	1.84	No	No	0	7	7
1042	S:S:H618	S:S:V594	4.15	No	No	0	9	9
1043	S:S:A614	S:S:C597	3.61	No	Yes	0	8	8
1044	S:S:C597	S:S:H618	4.42	Yes	No	0	8	9
1045	S:S:P604	S:S:V603	3.53	No	Yes	0	9	9
1046	S:S:H608	S:S:S605	4.18	No	No	0	9	9
1047	S:S:P610	S:S:S605	5.34	No	No	0	9	9
1048	S:S:A606	S:S:F607	2.77	No	No	0	9	8
1049	S:S:H608	S:S:R611	6.77	No	No	0	9	9
1050	S:S:E609	S:S:M613	2.71	Yes	Yes	14	9	7
1051	S:S:E609	S:S:K666	2.7	Yes	No	14	9	9
1052	S:S:R611	S:S:Y612	8.23	No	No	0	9	9
1053	S:S:L661	S:S:Y612	4.69	No	No	0	8	9
1054	S:S:P665	S:S:Y612	13.91	No	No	0	9	9
1055	S:S:L661	S:S:V615	2.98	No	No	0	8	7
1056	S:S:I623	S:S:N619	5.66	No	No	0	5	9
1057	S:S:N619	S:S:V657	4.43	No	No	0	9	7
1058	S:S:E620	S:S:S624	5.75	Yes	No	0	9	9
1059	S:S:E620	S:S:T654	5.64	Yes	Yes	0	9	9
1060	S:S:I622	S:S:I623	2.94	No	No	0	5	5
1061	S:S:I623	S:S:T654	3.04	No	Yes	0	5	9
1062	S:S:H628	S:S:S624	4.18	Yes	No	0	8	9
1063	S:S:H650	S:S:S624	4.18	Yes	No	0	9	9
1064	S:S:F627	S:S:H628	5.66	Yes	Yes	1	9	8
1065	S:S:F627	S:S:R631	9.62	Yes	Yes	1	9	9
1066	S:S:F627	S:S:L646	7.31	Yes	No	0	9	8
1067	S:S:F627	S:S:Y647	9.28	Yes	Yes	1	9	5
1068	S:S:F627	S:S:H650	24.89	Yes	Yes	0	9	9
1069	S:S:H628	S:S:R631	4.51	Yes	Yes	1	8	9
1070	S:S:F632	S:S:H628	3.39	Yes	Yes	1	9	8
1071	S:S:I630	S:S:L646	2.85	No	No	0	5	8
1072	S:S:F632	S:S:R631	7.48	Yes	Yes	1	9	9
1073	S:S:R631	S:S:Y647	8.23	Yes	Yes	1	9	5
1074	S:S:L634	S:S:V633	2.98	No	No	0	5	4
1075	S:S:L634	S:S:L638	2.77	No	No	0	5	8
1076	S:S:L638	S:S:W642	2.28	No	No	0	8	7
1077	S:S:L638	S:S:M643	2.83	No	No	0	8	8
1078	S:S:D641	S:S:Q639	7.83	Yes	Yes	0	9	9
1079	S:S:Q639	S:S:W642	5.48	Yes	No	0	9	7
1080	S:S:D641	S:S:L644	4.07	Yes	No	32	9	9
1081	S:S:M645	S:S:W642	2.33	No	No	0	7	7
1082	S:S:F648	S:S:H652	10.18	Yes	Yes	6	9	9
1083	S:S:H650	S:S:T654	6.85	Yes	Yes	0	9	9
1084	S:S:H652	S:S:T651	4.11	Yes	Yes	6	9	8
1085	S:S:T651	S:S:V655	4.76	Yes	Yes	6	8	7
1086	S:S:H652	S:S:T656	5.48	Yes	No	0	9	9
1087	S:S:T654	S:S:V655	3.17	Yes	Yes	0	9	7
1088	S:S:G660	S:S:I664	3.53	No	No	0	6	5
1089	S:S:F667	S:S:L663	6.09	Yes	No	0	8	8
1090	S:S:I664	S:S:P665	5.08	No	No	0	5	9
1091	W:W:?1	X:X:?2	30.51	Yes	Yes	1	0	0
1092	R:R:P79	R:R:V78	1.77	No	No	0	5	5
1093	R:R:P604	R:R:V603	1.77	No	No	0	9	9
1094	S:S:P79	S:S:V78	1.77	No	No	0	5	5
1095	S:S:P188	S:S:V190	1.77	No	No	0	8	7
1096	R:R:G523	R:R:I453	1.76	Yes	No	0	8	5
1097	R:R:G660	R:R:I664	1.76	No	No	0	6	5
1098	S:S:G560	S:S:I559	1.76	No	No	0	3	8
1099	R:R:G523	R:R:M527	1.75	Yes	No	27	8	7
1100	R:R:G524	R:R:M527	1.75	No	No	27	5	7
1101	S:S:G67	S:S:K329	1.74	No	Yes	0	3	5
1102	S:S:G89	S:S:K278	1.74	Yes	No	0	7	5
1103	S:S:G110	S:S:K111	1.74	No	No	0	6	3
1104	R:R:C99	R:R:S100	1.72	No	Yes	4	9	7
1105	R:R:G291	R:R:L140	1.71	No	Yes	0	8	8
1106	R:R:A194	R:R:S199	1.71	No	No	0	9	3
1107	R:R:A288	R:R:S261	1.71	No	No	0	7	4
1108	R:R:G280	R:R:L270	1.71	No	Yes	0	3	9
1109	R:R:G362	R:R:L364	1.71	No	No	0	3	3
1110	R:R:A444	R:R:S446	1.71	No	No	0	6	8
1111	R:R:G560	R:R:L574	1.71	No	No	0	3	7
1112	S:S:G67	S:S:L70	1.71	No	No	0	3	4
1113	S:S:G291	S:S:L140	1.71	No	No	0	8	8
1114	S:S:A194	S:S:S199	1.71	No	Yes	0	9	3
1115	S:S:A444	S:S:S446	1.71	No	No	0	6	8
1116	S:S:G491	S:S:L464	1.71	No	No	0	9	8
1117	R:R:A75	R:R:V82	1.7	No	No	0	3	7
1118	R:R:G275	R:R:N274	1.7	No	No	0	7	5
1119	R:R:A349	R:R:V366	1.7	No	No	0	7	4
1120	R:R:A493	R:R:V537	1.7	No	No	0	8	9
1121	S:S:G275	S:S:N274	1.7	No	No	0	7	5
1122	S:S:A493	S:S:V537	1.7	No	No	0	8	9
1123	S:S:I559	S:S:P476	1.69	No	No	0	8	9
1124	R:R:D66	R:R:G67	1.68	No	No	0	3	3
1125	R:R:D81	R:R:G101	1.68	No	No	0	6	4
1126	R:R:A187	R:R:T180	1.68	No	No	0	4	4
1127	R:R:A515	R:R:T514	1.68	No	No	0	9	8
1128	S:S:D66	S:S:G67	1.68	No	No	0	3	3
1129	S:S:D90	S:S:G89	1.68	No	Yes	0	7	7
1130	S:S:A187	S:S:T180	1.68	No	No	0	4	4
1131	S:S:M613	S:S:P610	1.68	Yes	No	0	7	9
1132	S:S:A616	S:S:T658	1.68	No	No	0	9	9
1133	R:R:K278	R:R:P279	1.67	No	No	0	5	9
1134	R:R:E168	R:R:G167	1.64	Yes	No	0	8	7
1135	R:R:L568	R:R:P407	1.64	No	Yes	0	7	9
1136	R:R:G562	R:R:Q561	1.64	No	No	0	7	5
1137	S:S:L364	S:S:P365	1.64	No	Yes	0	3	3
1138	R:R:S276	R:R:S91	1.63	No	No	0	4	4
1139	R:R:S379	R:R:S381	1.63	Yes	No	0	3	1
1140	S:S:S276	S:S:S91	1.63	No	No	0	4	4
1141	S:S:S121	S:S:S170	1.63	No	No	0	4	5
1142	S:S:S379	S:S:S381	1.63	Yes	No	0	3	1
1143	R:R:S163	S:S:V138	1.62	No	Yes	0	8	6
1144	R:R:S386	R:R:V385	1.62	No	No	0	4	1
1145	R:R:A425	R:R:I421	1.62	No	No	0	6	7
1146	S:S:A356	S:S:I315	1.62	No	No	0	3	8
1147	S:S:S462	S:S:V495	1.62	Yes	No	0	9	8
1148	S:S:S462	S:S:V655	1.62	Yes	Yes	6	9	7
1149	R:R:A97	R:R:M80	1.61	No	No	0	7	5
1150	S:S:A75	S:S:K355	1.61	No	No	0	3	6
1151	S:S:A175	S:S:K305	1.61	No	Yes	0	7	8
1152	R:R:S172	R:R:T195	1.6	No	No	0	5	8
1153	R:R:S179	R:R:T180	1.6	No	No	0	6	4
1154	R:R:S286	R:R:T284	1.6	No	No	0	9	8
1155	R:R:V433	R:R:V437	1.6	No	No	0	4	4
1156	R:R:S477	R:R:T478	1.6	No	No	0	9	6
1157	R:R:V499	R:R:V617	1.6	No	No	0	7	7
1158	R:R:V506	R:R:V600	1.6	No	Yes	0	9	9
1159	R:R:V594	R:R:V617	1.6	No	No	0	9	7
1160	S:S:V506	S:S:V603	1.6	No	Yes	33	9	9
1161	S:S:V600	S:S:V603	1.6	No	Yes	33	9	9
1162	R:R:T177	R:R:V303	1.59	No	No	0	8	9
1163	R:R:C549	R:R:L552	1.59	No	No	0	7	4
1164	R:R:T629	R:R:V633	1.59	No	No	0	4	4
1165	S:S:G89	S:S:H92	1.59	Yes	No	0	7	4
1166	S:S:C597	S:S:L503	1.59	Yes	No	0	8	8
1167	S:S:T629	S:S:V633	1.59	No	No	0	4	4
1168	R:R:A616	R:R:L661	1.58	No	No	0	9	8
1169	R:R:A616	R:R:L662	1.58	No	No	0	9	8
1170	S:S:A114	S:S:L126	1.58	No	Yes	0	1	4
1171	S:S:A132	S:S:L160	1.58	No	Yes	0	9	9
1172	S:S:A132	S:S:L164	1.58	No	No	0	9	5
1173	S:S:A174	S:S:L164	1.58	No	No	0	9	5
1174	S:S:I447	S:S:S446	1.55	No	No	0	9	8
1175	S:S:I542	S:S:S546	1.55	Yes	No	0	5	6
1176	R:R:H119	R:R:P120	1.53	No	No	0	4	3
1177	R:R:K264	R:R:S286	1.53	No	No	0	4	9
1178	R:R:M572	R:R:S636	1.53	No	No	0	6	5
1179	S:S:K95	S:S:S276	1.53	No	No	0	2	4
1180	S:S:M572	S:S:S636	1.53	No	No	0	6	5
1181	R:R:I69	R:R:T68	1.52	No	No	0	4	1
1182	R:R:K264	R:R:V303	1.52	No	No	0	4	9
1183	R:R:K305	R:R:V303	1.52	No	No	0	8	9
1184	R:R:C399	R:R:E397	1.52	Yes	Yes	17	9	6
1185	R:R:C408	R:R:E397	1.52	No	Yes	17	9	6
1186	R:R:I559	R:R:T478	1.52	No	No	0	8	6
1187	R:R:I630	R:R:T629	1.52	No	No	0	5	4
1188	S:S:I556	S:S:T478	1.52	No	No	0	5	6
1189	R:R:A75	R:R:E76	1.51	No	No	0	3	4
1190	R:R:F345	R:R:G344	1.51	No	Yes	0	9	9
1191	S:S:A75	S:S:E76	1.51	No	No	0	3	4
1192	S:S:A288	S:S:E299	1.51	No	No	0	7	8
1193	R:R:L164	R:R:S163	1.5	No	No	0	5	8
1194	R:R:L282	R:R:S172	1.5	No	No	0	7	5
1195	S:S:K383	S:S:T382	1.5	No	No	0	8	4
1196	R:R:L86	R:R:V82	1.49	No	No	0	8	7
1197	R:R:L661	R:R:V615	1.49	No	No	0	8	7
1198	S:S:L429	S:S:V433	1.49	No	No	0	4	4
1199	S:S:L507	S:S:V600	1.49	No	No	0	9	9
1200	R:R:D307	R:R:S172	1.47	No	No	0	9	5
1201	R:R:D404	R:R:S406	1.47	No	No	0	8	5
1202	R:R:L568	R:R:T564	1.47	No	No	0	7	9
1203	R:R:I622	R:R:I626	1.47	No	No	0	5	5
1204	R:R:L653	R:R:T654	1.47	No	Yes	0	6	9
1205	S:S:I622	S:S:I626	1.47	No	No	0	5	5
1206	S:S:I626	S:S:I630	1.47	No	No	0	5	5
1207	R:R:A116	R:R:H123	1.46	No	No	0	7	4
1208	R:R:I420	R:R:M645	1.46	No	No	0	8	7
1209	S:S:A389	S:S:H331	1.46	No	No	0	4	8
1210	R:R:D127	R:R:T130	1.45	No	Yes	0	5	4
1211	R:R:D566	R:R:T564	1.45	No	No	0	4	9
1212	R:R:F401	R:R:P407	1.44	No	Yes	0	4	9
1213	S:S:P519	S:S:R517	1.44	No	No	0	9	9
1214	S:S:Q555	S:S:S557	1.44	No	No	0	5	6
1215	S:S:I421	S:S:L418	1.43	No	No	0	7	5
1216	R:R:K329	R:R:L70	1.41	No	Yes	0	5	4
1217	R:R:K73	R:R:L74	1.41	No	No	0	4	4
1218	R:R:K508	R:R:L511	1.41	Yes	No	0	8	9
1219	S:S:L94	S:S:M80	1.41	No	No	0	9	5
1220	R:R:A487	R:R:F467	1.39	No	Yes	0	8	7
1221	R:R:C481	R:R:R485	1.39	No	No	0	9	9
1222	S:S:C99	S:S:R102	1.39	No	No	29	9	5
1223	S:S:C272	S:S:R102	1.39	No	No	29	9	5
1224	S:S:P279	S:S:Y277	1.39	No	No	0	9	8
1225	S:S:A487	S:S:F467	1.39	No	Yes	0	8	7
1226	S:S:C597	S:S:R601	1.39	Yes	No	0	8	9
1227	R:R:L472	R:R:L484	1.38	No	No	0	7	9
1228	S:S:L507	S:S:L511	1.38	No	No	0	9	9
1229	R:R:K95	R:R:Q93	1.36	No	Yes	0	2	4
1230	R:R:N367	R:R:N368	1.36	No	No	0	5	4
1231	S:S:P113	S:S:W112	1.35	No	Yes	0	5	4
1232	S:S:E553	S:S:K554	1.35	No	No	0	4	6
1233	R:R:F479	R:R:S477	1.32	No	No	0	8	9
1234	R:R:R637	R:R:S636	1.32	No	No	0	7	5
1235	S:S:F300	S:S:S179	1.32	Yes	No	0	8	6
1236	S:S:R301	S:S:S179	1.32	No	No	0	8	6
1237	S:S:N309	S:S:Q311	1.32	No	No	0	7	9
1238	S:S:N551	S:S:Q550	1.32	No	No	0	7	8
1239	S:S:R637	S:S:S636	1.32	No	No	0	7	5
1240	R:R:H123	R:R:L115	1.29	No	No	0	4	5
1241	R:R:R301	R:R:T180	1.29	No	No	0	8	4
1242	R:R:H567	R:R:L568	1.29	No	No	0	7	7
1243	R:R:Q411	R:R:Q639	1.28	No	Yes	0	7	9
1244	R:R:E197	R:R:E198	1.27	No	No	0	3	4
1245	S:S:E197	S:S:E198	1.27	No	No	0	3	4
1246	R:R:V509	R:R:Y520	1.26	No	Yes	1	8	8
1247	R:R:S84	R:R:W281	1.24	No	Yes	0	6	9
1248	R:R:K95	R:R:R96	1.24	No	No	0	2	3
1249	R:R:F432	R:R:M435	1.24	No	No	0	7	9
1250	S:S:K443	S:S:R442	1.24	No	No	0	4	9
1251	S:S:M521	S:S:R525	1.24	No	No	0	8	6
1252	S:S:F479	S:S:L483	1.22	No	No	0	8	7
1253	R:R:L452	R:R:R442	1.21	No	No	0	7	9
1254	R:R:Q516	R:R:R517	1.17	No	No	0	9	9
1255	S:S:L596	S:S:Y595	1.17	Yes	No	0	9	8
1256	R:R:E197	R:R:R196	1.16	No	No	0	3	8
1257	R:R:D413	R:R:Y415	1.15	No	No	0	8	4
1258	R:R:E299	R:R:Y290	1.12	No	No	0	8	8
1259	S:S:R601	S:S:Y598	1.03	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L70	4.09	4	0	4
2	R:R:D90	8.1175	4	19	7
3	R:R:Q93	8.2025	4	19	4
4	R:R:S100	3.9625	4	4	7
5	R:R:W112	4.83857	7	4	4
6	R:R:L129	4.7625	4	7	6
7	R:R:T130	4.19	5	7	4
8	R:R:H131	6.974	5	7	7
9	R:R:T133	2.96	5	7	8
10	R:R:F135	6.056	5	11	8
11	R:R:M139	4.65	4	5	7
12	R:R:L140	3.1575	4	0	8
13	R:R:Q151	4.08	4	5	5
14	R:R:W156	20.82	4	0	9
15	R:R:W162	3.91	4	16	7
16	R:R:E168	5.73333	6	20	8
17	R:R:R173	6.5375	4	23	7
18	R:R:F178	5.4	4	5	6
19	R:R:Q189	3.3275	4	5	6
20	R:R:F263	3.54	4	7	6
21	R:R:W265	6.8625	4	4	7
22	R:R:P268	4.3675	4	4	9
23	R:R:L270	4.8175	4	4	9
24	R:R:W281	5.95	8	4	9
25	R:R:S287	3.36	4	7	7
26	R:R:M304	6.2075	4	7	7
27	R:R:L310	3.345	4	0	8
28	R:R:W323	4.598	5	4	9
29	R:R:F324	3.375	4	4	9
30	R:R:C330	7.6125	4	2	9
31	R:R:L332	5.5	5	2	6
32	R:R:N333	6.245	4	2	9
33	R:R:C337	9.04	5	2	9
34	R:R:K341	14.785	6	2	3
35	R:R:G344	3.2475	4	2	9
36	R:R:Y350	10.56	5	8	9
37	R:R:E351	8.03667	6	2	4
38	R:R:C354	5.8325	4	8	9
39	R:R:P361	5.6725	4	8	5
40	R:R:P365	9.2975	4	8	3
41	R:R:R370	11.2067	6	2	1
42	R:R:R372	10.6743	7	2	1
43	R:R:H377	10.6971	7	2	3
44	R:R:I378	4.485	4	25	1
45	R:R:S379	3.625	4	0	3
46	R:R:C392	5.19	4	2	9
47	R:R:E397	3.9375	4	17	6
48	R:R:C399	4.0675	4	17	9
49	R:R:P407	2.5725	4	0	9
50	R:R:R417	5.388	5	26	9
51	R:R:Q424	3.586	5	9	9
52	R:R:M428	5.1075	4	9	7
53	R:R:L465	3.9325	4	0	9
54	R:R:Y466	4.94	6	9	8
55	R:R:F467	2.875	4	0	7
56	R:R:Y473	6.6075	4	0	8
57	R:R:I482	2.9475	4	1	7
58	R:R:W486	6.454	5	1	9
59	R:R:R488	4.0275	4	1	9
60	R:R:F492	6.85	6	1	9
61	R:R:V495	4.0825	4	0	8
62	R:R:Y496	10.905	4	1	9
63	R:R:T500	2.7925	4	1	7
64	R:R:K502	3.444	5	1	9
65	R:R:H504	6.382	5	1	9
66	R:R:R505	3.775	4	1	9
67	R:R:K508	6.155	4	1	8
68	R:R:I518	5.835	4	1	7
69	R:R:Y520	4.25714	7	1	8
70	R:R:G523	2.315	4	27	8
71	R:R:V526	4.6675	4	1	8
72	R:R:W539	6.504	5	1	9
73	R:R:F540	3.8625	4	0	9
74	R:R:L541	7.4975	4	1	9
75	R:R:W544	6.53	6	1	9
76	R:R:V548	5.125	4	1	6
77	R:R:W578	4.14875	8	1	9
78	R:R:M581	5.6	4	1	9
79	R:R:E586	7.8225	4	1	9
80	R:R:W592	6.778	5	1	9
81	R:R:L596	5.435	4	1	9
82	R:R:V600	3.065	4	0	9
83	R:R:E609	4.75	5	1	9
84	R:R:M613	4.625	4	1	7
85	R:R:E620	8.038	5	1	9
86	R:R:F627	10.766	5	1	9
87	R:R:H628	5.28	6	1	8
88	R:R:R631	6.44	4	1	9
89	R:R:F632	4.64	5	1	9
90	R:R:Q639	5.4175	4	0	9
91	R:R:Y647	5.388	5	1	5
92	R:R:F648	6.0225	4	9	9
93	R:R:H650	10.835	4	0	9
94	R:R:H652	6.12333	6	9	9
95	R:R:T654	3.478	5	0	9
96	R:R:V655	4.07	5	9	7
97	R:R:K666	4.35	4	1	9
98	R:R:F667	2.85	4	0	8
99	S:S:Y85	5.1975	4	0	8
100	S:S:G89	3.394	5	0	7
101	S:S:L105	9.1525	4	10	5
102	S:S:W112	11.54	4	0	4
103	S:S:L126	2.7375	4	12	4
104	S:S:L129	3.2675	4	0	6
105	S:S:T133	4.0625	4	12	8
106	S:S:F135	4.4	4	11	8
107	S:S:V138	3.51	5	16	6
108	S:S:R146	8.35	4	5	8
109	S:S:E147	4.53	4	22	9
110	S:S:W156	17.3025	4	5	9
111	S:S:Y157	7.326	5	22	9
112	S:S:L160	3.6525	4	11	9
113	S:S:W162	6.42	4	15	7
114	S:S:E168	7.2775	4	0	8
115	S:S:I171	4.205	4	0	8
116	S:S:F191	3.606	5	0	8
117	S:S:Q193	8.365	4	15	8
118	S:S:S199	4.94	4	15	3
119	S:S:F263	5.15	4	12	6
120	S:S:W265	6.0675	4	0	7
121	S:S:W281	6.134	5	0	9
122	S:S:L285	5.23	4	0	9
123	S:S:F300	3.945	4	0	8
124	S:S:K305	3.815	4	31	8
125	S:S:I308	3.7725	4	0	6
126	S:S:D316	5.805	4	0	8
127	S:S:W323	7.90167	6	0	9
128	S:S:S325	4.77	4	10	7
129	S:S:K329	5.574	5	10	5
130	S:S:N333	8.244	5	3	9
131	S:S:C337	8.8575	4	3	9
132	S:S:K341	9.564	5	3	3
133	S:S:G344	3.198	5	3	9
134	S:S:Y350	10.23	4	10	9
135	S:S:P361	4.9425	4	30	5
136	S:S:P365	6.825	4	10	3
137	S:S:R370	9.39167	6	3	1
138	S:S:R372	7.34	6	3	1
139	S:S:P374	5.8025	4	3	1
140	S:S:Q376	11.055	4	3	3
141	S:S:H377	10.888	5	3	3
142	S:S:S379	4.625	4	3	3
143	S:S:D384	10.4	4	13	1
144	S:S:Y390	12.4175	4	13	5
145	S:S:C399	2.46167	6	18	9
146	S:S:P407	5.5875	4	18	9
147	S:S:L416	3.82	4	0	9
148	S:S:R417	7.89	4	32	9
149	S:S:Q424	5.59833	6	6	9
150	S:S:D431	5.2	4	6	6
151	S:S:M435	3.3225	4	0	9
152	S:S:S450	4.1975	4	14	9
153	S:S:S462	3.075	4	6	9
154	S:S:Y466	5.105	6	6	8
155	S:S:F467	3.185	4	0	7
156	S:S:I482	2.8275	4	1	7
157	S:S:R485	5.58	4	1	9
158	S:S:W486	5.034	5	1	9
159	S:S:R488	5.4825	4	1	9
160	S:S:F492	6.30167	6	1	9
161	S:S:Y496	12.435	4	1	9
162	S:S:T500	2.77	4	1	7
163	S:S:L501	3.21	4	0	9
164	S:S:K502	4.8425	4	14	9
165	S:S:H504	4.2225	4	1	9
166	S:S:Y520	5.608	5	0	8
167	S:S:M527	4.5425	4	0	7
168	S:S:W539	5.602	5	1	9
169	S:S:F540	4.15167	6	1	9
170	S:S:I542	4.875	4	1	5
171	S:S:W544	6.36	6	1	9
172	S:S:F570	3.464	5	0	9
173	S:S:W578	4.82125	8	1	9
174	S:S:D579	4.08	4	1	9
175	S:S:M581	5.165	4	1	9
176	S:S:F589	3.44833	6	1	8
177	S:S:W592	6.37	5	1	9
178	S:S:L596	4.2275	4	1	9
179	S:S:C597	2.7525	4	0	8
180	S:S:V603	3.32	4	33	9
181	S:S:E609	4.4775	4	14	9
182	S:S:M613	3.198	5	14	7
183	S:S:E620	8.72	5	1	9
184	S:S:F627	11.352	5	1	9
185	S:S:H628	4.09833	6	1	8
186	S:S:R631	6.682	5	1	9
187	S:S:F632	4.98167	6	1	9
188	S:S:Q639	4.63	4	0	9
189	S:S:D641	4.545	4	32	9
190	S:S:Y647	6.83	4	1	5
191	S:S:F648	5.75	4	6	9
192	S:S:H650	10.1075	4	0	9
193	S:S:T651	4.615	4	6	8
194	S:S:H652	7.01833	6	6	9
195	S:S:T654	4.675	4	0	9
196	S:S:V655	4.364	5	6	7
197	S:S:F667	4.2325	4	0	8
198	W:W:?1	5.81375	24	1	0
199	X:X:?2	7.022	15	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q317	R:R:Y350	24.4259	9.02	No	Yes	0	9	9
2	R:R:Q317	R:R:S319	23.4245	2.89	No	No	0	9	7
3	R:R:E351	R:R:S319	23.2241	5.75	Yes	No	0	4	7
4	R:R:C354	R:R:Y350	25.1698	2.69	Yes	Yes	8	9	9
5	R:R:F324	R:R:K355	29.1284	3.72	Yes	No	0	9	6
6	R:R:C354	R:R:K355	28.9295	6.47	Yes	No	0	9	6
7	R:R:F324	R:R:W112	29.3029	2	Yes	Yes	4	9	4
8	R:R:W112	R:R:W265	44.9675	11.25	Yes	Yes	4	4	7
9	R:R:L285	R:R:W265	47.9594	9.11	No	Yes	0	9	7
10	R:R:F263	R:R:L126	48.1522	2.44	Yes	No	0	6	4
11	R:R:L126	R:R:L285	47.9575	5.54	No	No	0	4	9
12	R:R:M304	R:R:S287	16.2419	4.6	Yes	Yes	7	7	7
13	R:R:L129	R:R:M304	10.9603	5.65	Yes	Yes	7	6	7
14	R:R:F263	R:R:T130	53.4908	6.49	Yes	Yes	7	6	4
15	R:R:H131	R:R:T130	65.4481	5.48	Yes	Yes	7	7	4
16	R:R:N134	R:R:T133	11.582	2.92	No	Yes	7	9	8
17	R:R:H131	S:S:R124	38.7024	6.77	Yes	No	0	7	5
18	R:R:H131	S:S:T128	38.6945	6.85	Yes	No	7	7	8
19	R:R:L165	R:R:S199	11.8688	3	No	No	0	6	3
20	R:R:L165	R:R:Q193	13.8466	3.99	No	No	0	6	8
21	R:R:Q193	R:R:V161	15.8092	5.73	No	No	0	8	9
22	R:R:I176	R:R:V161	16.7974	6.14	No	No	0	7	9
23	R:R:I176	R:R:M304	23.8198	5.83	No	Yes	0	7	7
24	S:S:E168	S:S:R124	38.8853	11.63	Yes	No	0	8	5
25	S:S:E168	S:S:I171	79.3197	4.1	Yes	Yes	0	8	8
26	S:S:E168	S:S:T128	40.2635	8.47	Yes	No	0	8	8
27	R:R:R370	R:R:V346	12.3264	22.23	Yes	No	0	1	7
28	R:R:E351	R:R:V346	17.376	7.13	Yes	No	0	4	7
29	R:R:E586	W:W:?1	14.6112	4.17	Yes	Yes	1	9	0
30	W:W:?1	X:X:?2	47.0841	30.51	Yes	Yes	1	0	0
31	S:S:F492	X:X:?2	89.1765	2.2	Yes	Yes	1	9	0
32	S:S:F492	S:S:R488	44.3829	3.21	Yes	Yes	1	9	9
33	S:S:L465	S:S:R488	45.2795	6.07	No	Yes	0	9	9
34	S:S:L465	S:S:V655	45.4296	5.96	No	Yes	0	9	7
35	S:S:V655	S:S:Y466	96.454	6.31	Yes	Yes	6	7	8
36	S:S:M428	S:S:Y466	96.105	8.38	No	Yes	0	7	8
37	S:S:F467	S:S:M428	96.1417	6.22	Yes	No	0	7	7
38	S:S:F467	S:S:V470	96.3635	2.62	Yes	No	0	7	7
39	S:S:I421	S:S:V470	96.4004	3.07	No	No	0	7	7
40	S:S:I421	S:S:Y473	96.5113	9.67	No	No	0	7	8
41	S:S:F474	S:S:Y473	98.3886	6.19	No	No	0	8	8
42	S:S:F474	S:S:R480	98.4248	9.62	No	No	0	8	9
43	S:S:E475	S:S:R480	98.4972	2.33	No	No	0	5	9
44	S:S:E475	S:S:P476	98.5333	3.14	No	No	0	5	9
45	S:S:N571	S:S:P476	98.8574	4.89	No	No	0	5	9
46	S:S:N571	S:S:Q561	98.8933	2.64	No	No	0	5	5
47	S:S:I569	S:S:Q561	98.9291	8.23	No	No	0	5	5
48	S:S:C408	S:S:I569	98.965	3.27	No	No	0	9	5
49	S:S:C399	S:S:C408	99.0008	1.82	Yes	No	0	9	9
50	S:S:C399	S:S:P400	99.3571	1.88	Yes	No	0	9	3
51	S:S:P374	S:S:P400	99.3926	5.84	Yes	No	0	1	3
52	S:S:P374	S:S:R372	99.3817	10.09	Yes	Yes	3	1	1
53	S:S:K341	S:S:R372	50.0404	13.61	Yes	Yes	3	3	1
54	S:S:K341	S:S:R370	49.9984	16.09	Yes	Yes	3	3	1
55	S:S:N333	S:S:R370	100	2.41	Yes	Yes	3	9	1
56	S:S:E351	S:S:N333	99.974	15.77	No	Yes	0	4	9
57	S:S:E351	S:S:S319	99.8818	14.37	No	No	0	4	7
58	S:S:S319	S:S:S320	99.8633	3.26	No	No	0	7	4
59	S:S:Q317	S:S:S320	99.8447	10.11	No	No	0	9	4
60	S:S:D316	S:S:Q317	99.8262	11.75	Yes	No	0	8	9
61	S:S:D316	S:S:W323	98.6048	2.23	Yes	Yes	0	8	9
62	S:S:L122	S:S:W323	95.3345	5.69	No	Yes	0	7	9
63	S:S:L122	S:S:W265	47.6312	3.42	No	Yes	0	7	7
64	S:S:L285	S:S:W265	48.0558	12.53	Yes	Yes	0	9	7
65	S:S:L129	S:S:L285	93.1402	2.77	Yes	Yes	0	6	9
66	S:S:L129	S:S:V306	88.9552	4.47	Yes	No	0	6	7
67	S:S:I171	S:S:V306	88.8694	3.07	Yes	No	0	8	7
68	S:S:E620	S:S:F492	44.3546	4.66	Yes	Yes	1	9	9
69	S:S:E620	S:S:T654	45.7355	5.64	Yes	Yes	0	9	9
70	S:S:T654	S:S:V655	50.2282	3.17	Yes	Yes	0	9	7
71	S:S:G344	S:S:R372	49.5293	3	Yes	Yes	3	9	1
72	S:S:G344	S:S:R370	49.5643	3	Yes	Yes	3	9	1
73	S:S:I308	S:S:L122	47.6811	2.85	Yes	No	0	6	7
74	S:S:I308	S:S:L285	47.5742	2.85	Yes	Yes	0	6	9
75	R:R:F492	W:W:?1	13.5905	3.84	Yes	Yes	1	9	0
76	R:R:K502	R:R:L454	17.3275	4.23	Yes	No	1	9	9
77	R:R:R505	R:R:Y520	10.8896	6.17	Yes	Yes	1	9	8
78	R:R:H504	R:R:Y520	11.1112	2.18	Yes	Yes	1	9	8
79	R:R:H504	X:X:?2	13.1605	6.98	Yes	Yes	1	9	0
80	R:R:K508	R:R:Y520	11.094	2.39	Yes	Yes	1	8	8
81	R:R:K508	X:X:?2	11.35	5.1	Yes	Yes	1	8	0
82	S:S:L503	S:S:L596	14.2266	2.77	No	Yes	0	8	9
83	S:S:L503	S:S:M613	11.543	4.24	No	Yes	0	8	7
84	R:R:P268	R:R:W112	14.1141	5.4	Yes	Yes	4	9	4
85	R:R:L129	R:R:T133	11.7781	2.95	Yes	Yes	7	6	8
86	R:R:T130	R:R:T133	11.5815	3.14	Yes	Yes	7	4	8
87	R:R:H131	R:R:N134	11.7729	3.83	Yes	No	7	7	9
88	R:R:S287	R:R:T133	10.9918	3.2	Yes	Yes	7	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F540	R:R:L489	2.44	0	Yes	No	9	7	1	2
R:R:E586	R:R:F492	16.32	1	Yes	Yes	9	9	2	2
R:R:F492	W:W:?1	3.84	1	Yes	Yes	9	0	2	1
R:R:F589	R:R:T500	3.89	1	No	Yes	8	7	2	2
R:R:T500	R:R:W592	3.64	1	Yes	Yes	7	9	2	1
R:R:H504	R:R:K508	15.72	1	Yes	Yes	9	8	1	1
R:R:H504	R:R:Y520	2.18	1	Yes	Yes	9	8	1	2
R:R:H504	R:R:W592	3.17	1	Yes	Yes	9	9	1	1
R:R:H504	R:R:L596	3.86	1	Yes	Yes	9	9	1	2
R:R:H504	X:X:?2	6.98	1	Yes	Yes	9	0	1	0
R:R:K508	R:R:Y520	2.39	1	Yes	Yes	8	8	1	2
R:R:K508	X:X:?2	5.1	1	Yes	Yes	8	0	1	0
R:R:R525	R:R:Y520	4.12	0	No	Yes	6	8	2	2
R:R:M529	R:R:Y520	3.59	0	No	Yes	7	8	2	2
R:R:R525	W:W:?1	4.59	0	No	Yes	6	0	2	1
R:R:M529	W:W:?1	8.91	0	No	Yes	7	0	2	1
R:R:V532	W:W:?1	4.69	0	No	Yes	7	0	2	1
R:R:I533	W:W:?1	4.5	0	No	Yes	8	0	2	1
R:R:L535	W:W:?1	2.62	0	No	Yes	9	0	2	1
R:R:V536	W:W:?1	8.45	0	No	Yes	7	0	2	1
R:R:V537	W:W:?1	1.88	0	No	Yes	9	0	2	1
R:R:W539	S:S:A585	3.89	1	Yes	No	9	9	2	2
R:R:W539	W:W:?1	12.92	1	Yes	Yes	9	0	2	1
R:R:F540	R:R:W578	6.01	0	Yes	Yes	9	9	1	2
R:R:F540	R:R:T582	2.59	0	Yes	No	9	8	1	2
R:R:F540	X:X:?2	4.41	0	Yes	Yes	9	0	1	0
R:R:M581	R:R:W578	4.65	1	Yes	Yes	9	9	2	2
R:R:W578	S:S:W539	1.87	1	Yes	Yes	9	9	2	1
R:R:W578	S:S:F540	4.01	1	Yes	Yes	9	9	2	2
R:R:M581	S:S:W539	8.14	1	Yes	Yes	9	9	2	1
R:R:T582	S:S:W539	2.43	0	No	Yes	8	9	2	1
R:R:L588	R:R:V584	4.47	0	No	No	8	6	1	2
R:R:A585	S:S:W539	3.89	1	No	Yes	9	9	1	1
R:R:A585	X:X:?2	2.85	1	No	Yes	9	0	1	0
R:R:E586	W:W:?1	4.17	1	Yes	Yes	9	0	2	1
R:R:L588	X:X:?2	2.51	0	No	Yes	8	0	1	0
R:R:F589	R:R:W592	4.01	1	No	Yes	8	9	2	1
R:R:F589	W:W:?1	3.07	1	No	Yes	8	0	2	1
R:R:L596	R:R:W592	11.39	1	Yes	Yes	9	9	2	1
R:R:W592	X:X:?2	11.68	1	Yes	Yes	9	0	1	0
S:S:F492	S:S:R488	3.21	1	Yes	Yes	9	9	1	2
S:S:E586	S:S:R488	8.14	1	No	Yes	9	9	2	2
S:S:F540	S:S:L489	2.44	1	Yes	No	9	7	2	2
S:S:L489	W:W:?1	2.62	1	No	Yes	7	0	2	1
S:S:F492	S:S:Y496	12.38	1	Yes	Yes	9	9	1	2
S:S:E586	S:S:F492	10.49	1	No	Yes	9	9	2	1
S:S:F492	S:S:L590	4.87	1	Yes	No	9	9	1	2
S:S:E620	S:S:F492	4.66	1	Yes	Yes	9	9	2	1
S:S:F492	X:X:?2	2.2	1	Yes	Yes	9	0	1	0
S:S:E620	S:S:Y496	23.57	1	Yes	Yes	9	9	2	2
S:S:G497	S:S:T500	1.82	1	No	Yes	9	7	2	2
S:S:F589	S:S:G497	3.01	1	Yes	No	8	9	1	2
S:S:F589	S:S:T500	2.59	1	Yes	Yes	8	7	1	2
S:S:T500	S:S:W592	4.85	1	Yes	Yes	7	9	2	2
S:S:L501	S:S:M529	4.24	0	Yes	No	9	7	2	1
S:S:I533	S:S:L501	2.85	1	No	Yes	8	9	1	2
S:S:H504	S:S:K508	5.24	1	Yes	No	9	8	2	2
S:S:H504	S:S:W592	2.12	1	Yes	Yes	9	9	2	2
S:S:H504	W:W:?1	5.67	1	Yes	Yes	9	0	2	1
S:S:K508	W:W:?1	5.33	1	No	Yes	8	0	2	1
S:S:M529	W:W:?1	3.56	1	No	Yes	7	0	1	1
S:S:M529	X:X:?2	9.38	1	No	Yes	7	0	1	0
S:S:V532	W:W:?1	1.88	1	No	Yes	7	0	1	1
S:S:V532	X:X:?2	4.49	1	No	Yes	7	0	1	0
S:S:F589	S:S:I533	2.51	1	Yes	No	8	8	1	1
S:S:I533	X:X:?2	3.44	1	No	Yes	8	0	1	0
S:S:L535	X:X:?2	2.51	0	No	Yes	9	0	1	0
S:S:V536	W:W:?1	1.88	1	No	Yes	7	0	1	1
S:S:V536	X:X:?2	5.39	1	No	Yes	7	0	1	0
S:S:V537	W:W:?1	1.88	0	No	Yes	9	0	2	1
S:S:W539	X:X:?2	11.68	1	Yes	Yes	9	0	1	0
S:S:F540	W:W:?1	3.84	1	Yes	Yes	9	0	2	1
S:S:A585	W:W:?1	3.97	1	No	Yes	9	0	2	1
S:S:L588	W:W:?1	2.62	0	No	Yes	8	0	2	1
S:S:F589	S:S:W592	5.01	1	Yes	Yes	8	9	1	2
S:S:F589	W:W:?1	5.37	1	Yes	Yes	8	0	1	1
S:S:F589	X:X:?2	2.2	1	Yes	Yes	8	0	1	0
S:S:E620	S:S:L590	3.98	1	Yes	No	9	9	2	2
S:S:W592	W:W:?1	10.76	1	Yes	Yes	9	0	2	1
W:W:?1	X:X:?2	30.51	1	Yes	Yes	0	0	1	0
R:R:K508	R:R:L511	1.41	1	Yes	No	8	9	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
77.78	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
77.78	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
70.59	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
41.18	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
39.13	Single	5KW2	PubChem 133053953	5KW2-FFA1 (GPR40)-PubChem 133053953
31.82	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
31.58	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
31.58	Consensus	c5a1_off_ortoallo	Other Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
31.25	Single	6OBA	GTPL11074	6OBA-β₂-(S)-Alprenolol-GTPL11074
31.25	Consensus	beta2_off_allo	Other Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
29.41	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
23.53	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
21.05	Consensus	d1_on_allo	Other Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
14.29	Single	8IYX	YL-365	8IYX-GPR34-YL-365
12.50	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
12.50	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
12.50	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
10.71	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
10.00	Single	7LJD	Mevidalen	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
10.00	Single	7X2F	Mevidalen	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
10.00	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
9.52	Single	7LJC	Mevidalen	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
9.52	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
9.52	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
9.52	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
9.52	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
9.52	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
8.70	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Consensus	adgrf1_on_allo	Other Ligand	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
8.33	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.00	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
8.00	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
8.00	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
8.00	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
7.69	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
7.69	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
7.69	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
7.41	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
7.41	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
7.41	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
7.41	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
7.41	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
7.41	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
7.41	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
7.14	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
7.14	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
7.14	Consensus	class-c_off	Other Ligand	gabab_off mglu_off
7.14	Consensus	class-d_off	Orthosteric Ligand	ste2_off
6.90	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
6.90	Single	7QA8	Peptide	7QA8-STE2-Peptide
6.90	Single	7QA8	Peptide	7QA8-STE2-Peptide
6.90	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
6.90	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
6.90	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
6.90	Consensus	class-d_off	Orthosteric Ligand	ste2_off
6.25	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
6.25	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
6.25	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.88	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
5.88	Consensus	class-d_on	Orthosteric Ligand	ste2_on
5.71	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.71	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
5.71	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
5.71	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.56	Single	5XSZ	Glyceryl Mono-oleate	5XSZ-LPA₆-Glyceryl Mono-oleate
5.56	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
5.56	Single	8GEJ	Epinephrine	8GEJ-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
5.56	Consensus	gabab_off	Other Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.26	Single	6KQI	ORG27569	6KQI-CB₁-PubMed 104895-ORG27569
5.26	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8IWM	2-Phenylethylamine	8IWM-TAAR9-2-Phenylethylamine
5.26	Single	8WC5	Tetramethylammonium ion	8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	cb1_off_allo	Other Ligand	6KQI-CB₁-PubMed 104895-ORG27569
5.26	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.00	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
5.00	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8GGR	Epinephrine	8GGR-β₂-Epinephrine
5.00	Single	8GGZ	Epinephrine	8GGZ-β₂-Epinephrine
5.00	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.00	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
5.00	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
4.76	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2
4.76	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
4.76	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.76	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
4.76	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
4.76	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
4.76	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
4.76	Single	8GEI	Epinephrine	8GEI-β₂-Epinephrine-Gs/&β;1/&γ;2
4.76	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.76	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.76	Single	8GGS	Epinephrine	8GGS-β₂-Epinephrine
4.76	Single	8GGY	Epinephrine	8GGY-β₂-Epinephrine
4.76	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
4.76	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
4.76	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
4.76	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
4.76	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
4.76	Single	8J6Q	Compound 9n	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.76	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.76	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
4.76	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
4.76	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
4.76	Single	8UNV	Epinephrine	8UNV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.76	Single	8UNX	Epinephrine	8UNX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.76	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
4.76	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
4.76	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
4.76	Consensus	hca2_on_allo	Other Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.55	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
4.55	Single	6AKX	A4R	6AKX-CCR5-A4R
4.55	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
4.55	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
4.55	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
4.55	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
4.55	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
4.55	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
4.55	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
4.55	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
4.55	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
4.55	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
4.55	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
4.55	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
4.55	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
4.55	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
4.55	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
4.55	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
4.55	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
4.55	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
4.55	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.55	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
4.55	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
4.55	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
4.55	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
4.55	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
4.55	Single	8G94	CD69	8G94-S1P₁-CD69-Gi1/&β;1/&γ;2
4.55	Single	8GEA	Epinephrine	8GEA-β₂-Epinephrine-Gs/&β;1/&γ;2
4.55	Single	8GEC	Epinephrine	8GEC-β₂-Epinephrine-Gs/&β;1/&γ;2
4.55	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
4.55	Single	8GEF	Epinephrine	8GEF-β₂-Epinephrine-Gs/&β;1/&γ;2
4.55	Single	8GG7	Epinephrine	8GG7-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8GGA	Epinephrine	8GGA-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8GGV	Epinephrine	8GGV-β₂-Epinephrine
4.55	Single	8GGW	Epinephrine	8GGW-β₂-Epinephrine
4.55	Single	8GGX	Epinephrine	8GGX-β₂-Epinephrine
4.55	Single	8GH0	Epinephrine	8GH0-β₂-Epinephrine
4.55	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
4.55	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
4.55	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
4.55	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
4.55	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
4.55	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.55	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2
4.55	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8UNO	Epinephrine	8UNO-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.55	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
4.55	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
4.55	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	5ht2_on	Orthosteric Ligand	5ht2a_on 5ht2c_on
4.55	Consensus	5ht2c_on	Orthosteric Ligand	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
4.55	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
4.55	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
4.55	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
4.55	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
4.55	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
4.55	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
4.35	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
4.35	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
4.35	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
4.35	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
4.35	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
4.35	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
4.35	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
4.35	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
4.35	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
4.35	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
4.35	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
4.35	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
4.35	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
4.35	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
4.35	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
4.35	Single	6TPG	EMPA	6TPG-OX₂-EMPA
4.35	Single	6TPK	Retosiban	6TPK-OT-Retosiban
4.35	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
4.35	Single	6VI4	JDTic	6VI4-κ-JDTic
4.35	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
4.35	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
4.35	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
4.35	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
4.35	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
4.35	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
4.35	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.35	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
4.35	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
4.35	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
4.35	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
4.35	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
4.35	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
4.35	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
4.35	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
4.35	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
4.35	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
4.35	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
4.35	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
4.35	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
4.35	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
4.35	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
4.35	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
4.35	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
4.35	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.35	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
4.35	Single	8GE1	Epinephrine	8GE1-β₂-Epinephrine-Gs/&β;1/&γ;2
4.35	Single	8GE4	Epinephrine	8GE4-β₂-Epinephrine-Gs/&β;1/&γ;2
4.35	Single	8GE6	Epinephrine	8GE6-β₂-Epinephrine-Gs/&β;1/&γ;2
4.35	Single	8GE7	Epinephrine	8GE7-β₂-Epinephrine-Gs/&β;1/&γ;2
4.35	Single	8GE8	Epinephrine	8GE8-β₂-Epinephrine-Gs/&β;1/&γ;2
4.35	Single	8GE9	Epinephrine	8GE9-β₂-Epinephrine-Gs/&β;1/&γ;2
4.35	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
4.35	Single	8GFV	Epinephrine	8GFV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8GG4	Epinephrine	8GG4-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8GGI	Epinephrine	8GGI-β₂-Epinephrine
4.35	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
4.35	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
4.35	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
4.35	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
4.35	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
4.35	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
4.35	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
4.35	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
4.35	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
4.35	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.35	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
4.35	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
4.35	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
4.35	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
4.35	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
4.35	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
4.35	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
4.35	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
4.35	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
4.35	Single	8UNQ	Epinephrine	8UNQ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.35	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
4.35	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
4.35	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
4.35	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
4.35	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
4.35	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
4.35	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
4.35	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
4.35	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
4.35	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
4.35	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
4.35	Consensus	hcar_on	Orthosteric Ligand	hca_on
4.35	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
4.35	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
4.35	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
4.35	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
4.35	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
4.35	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
4.35	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
4.35	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
4.17	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
4.17	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
4.17	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
4.17	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
4.17	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
4.17	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
4.17	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
4.17	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
4.17	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
4.17	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
4.17	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
4.17	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
4.17	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
4.17	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
4.17	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
4.17	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
4.17	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
4.17	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
4.17	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
4.17	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
4.17	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
4.17	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
4.17	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
4.17	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
4.17	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
4.17	Single	6PS1	Timolol	6PS1-β₂-Timolol
4.17	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
4.17	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
4.17	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
4.17	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
4.17	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
4.17	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
4.17	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
4.17	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
4.17	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
4.17	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
4.17	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
4.17	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
4.17	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
4.17	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
4.17	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
4.17	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
4.17	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
4.17	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
4.17	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
4.17	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
4.17	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
4.17	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
4.17	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
4.17	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
4.17	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
4.17	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
4.17	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
4.17	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
4.17	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
4.17	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
4.17	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
4.17	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
4.17	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
4.17	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
4.17	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
4.17	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
4.17	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
4.17	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
4.17	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
4.17	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
4.17	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
4.17	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
4.17	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
4.17	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
4.17	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
4.17	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
4.17	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.17	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
4.17	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
4.17	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
4.17	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
4.17	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.17	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
4.17	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
4.17	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
4.17	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
4.17	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
4.17	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
4.17	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
4.17	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
4.17	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
4.17	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
4.17	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
4.17	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
4.17	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
4.17	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
4.17	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
4.17	Consensus	blt_on	Orthosteric Ligand	blt1_on
4.17	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.17	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
4.17	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
4.17	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.17	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
4.17	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.17	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
4.17	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
4.17	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.17	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
4.17	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
4.17	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
4.17	Consensus	leuko_on	Orthosteric Ligand	blt_on
4.17	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.17	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
4.17	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.17	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
4.17	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
4.17	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.17	Consensus	tar_on	Orthosteric Ligand	ta1_on
4.00	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
4.00	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
4.00	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
4.00	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
4.00	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
4.00	Single	5C1M	BU72	5C1M-μ-BU72
4.00	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
4.00	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
4.00	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
4.00	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
4.00	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
4.00	Single	5WQC	EMPA	5WQC-OX₂-EMPA
4.00	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
4.00	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
4.00	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
4.00	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
4.00	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
4.00	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
4.00	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
4.00	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
4.00	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
4.00	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
4.00	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
4.00	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.00	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
4.00	Single	6PS6	Timolol	6PS6-β₂-Timolol
4.00	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
4.00	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
4.00	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
4.00	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
4.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
4.00	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
4.00	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
4.00	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
4.00	Single	7C4S	S1P	7C4S-S1P₃-S1P
4.00	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
4.00	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
4.00	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
4.00	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.00	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
4.00	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
4.00	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.00	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
4.00	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
4.00	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.00	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
4.00	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
4.00	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
4.00	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
4.00	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
4.00	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.00	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
4.00	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
4.00	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
4.00	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
4.00	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
4.00	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
4.00	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
4.00	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
4.00	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
4.00	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
4.00	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
4.00	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
4.00	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
4.00	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
4.00	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.00	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
4.00	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
4.00	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
4.00	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
4.00	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
4.00	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
4.00	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
4.00	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
4.00	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
4.00	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
4.00	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
4.00	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
4.00	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
4.00	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
4.00	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
4.00	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
4.00	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
4.00	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
4.00	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
4.00	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.00	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
4.00	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.00	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
4.00	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	2YDV	NECA	2YDV-A_2A-NECA
3.85	Single	3P0G	BI167107	3P0G-β₂-BI167107
3.85	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
3.85	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
3.85	Single	4DJH	JDTic	4DJH-κ-JDTic
3.85	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
3.85	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
3.85	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
3.85	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
3.85	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
3.85	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
3.85	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
3.85	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
3.85	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
3.85	Single	5G53	NECA	5G53-A_2A-NECA-Gs
3.85	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
3.85	Single	5XR8	AM841	5XR8-CB₁-AM841
3.85	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
3.85	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
3.85	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
3.85	Single	6E59	L-760735	6E59-NK₁-L-760735
3.85	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
3.85	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
3.85	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
3.85	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
3.85	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
3.85	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
3.85	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
3.85	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
3.85	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
3.85	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
3.85	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
3.85	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
3.85	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
3.85	Single	7EPE	NAM563	7EPE-mGlu-NAM563
3.85	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
3.85	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
3.85	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
3.85	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
3.85	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
3.85	Single	7P2L	4YI	7P2L-mGlu₅-4YI
3.85	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
3.85	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
3.85	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
3.85	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
3.85	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
3.85	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
3.85	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
3.85	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
3.85	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
3.85	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
3.85	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
3.85	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
3.85	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
3.85	Single	8E0G	BU72	8E0G-μ-BU72
3.85	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
3.85	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
3.85	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
3.85	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
3.85	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.85	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
3.85	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
3.85	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
3.85	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
3.85	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
3.85	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
3.85	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
3.85	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
3.85	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.85	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
3.85	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
3.85	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
3.85	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
3.85	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
3.85	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
3.85	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
3.85	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
3.85	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
3.85	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
3.85	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
3.85	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
3.85	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
3.85	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
3.85	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
3.85	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
3.85	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
3.85	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
3.85	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
3.85	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
3.85	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
3.85	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
3.85	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
3.85	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
3.85	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
3.85	Consensus	histamine_off	Orthosteric Ligand	h1_off
3.85	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
3.85	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
3.85	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
3.85	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.85	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
3.85	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
3.85	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
3.85	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
3.85	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.85	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
3.85	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
3.85	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
3.70	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
3.70	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
3.70	Single	4LDE	BI167107	4LDE-β₂-BI167107
3.70	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
3.70	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
3.70	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
3.70	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
3.70	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
3.70	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
3.70	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
3.70	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
3.70	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
3.70	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
3.70	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
3.70	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
3.70	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
3.70	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.70	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.70	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.70	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
3.70	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
3.70	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
3.70	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
3.70	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
3.70	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
3.70	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
3.70	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.70	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.70	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
3.70	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
3.70	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
3.70	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
3.70	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
3.70	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
3.70	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
3.70	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
3.70	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
3.70	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
3.70	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
3.70	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
3.70	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
3.70	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
3.70	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
3.70	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
3.70	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
3.70	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
3.70	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
3.70	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
3.70	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
3.70	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
3.70	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
3.70	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
3.70	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
3.70	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
3.70	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
3.70	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
3.70	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
3.70	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
3.70	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
3.70	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
3.70	Consensus	gi_class-f	Other Ligand	gi_frizzled
3.70	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.70	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
3.70	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
3.70	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
3.70	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
3.70	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
3.70	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
3.70	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
3.70	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
3.70	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
3.70	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
3.70	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
3.70	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
3.70	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
3.70	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
3.70	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
3.57	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
3.57	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
3.57	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
3.57	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
3.57	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
3.57	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
3.57	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
3.57	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
3.57	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
3.57	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
3.57	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
3.57	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
3.57	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
3.57	Single	7EZC	UKA	7EZC-A_2A-UKA
3.57	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
3.57	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
3.57	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
3.57	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
3.57	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
3.57	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
3.57	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
3.57	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
3.57	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
3.57	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
3.57	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
3.57	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
3.57	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
3.57	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
3.57	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
3.57	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
3.57	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
3.57	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.57	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
3.57	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
3.57	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
3.57	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
3.57	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
3.57	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
3.57	Consensus	endothelin_off	Orthosteric Ligand	etb_off
3.57	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
3.57	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
3.57	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
3.57	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
3.57	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
3.57	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	orexin_on	Orthosteric Ligand	ox2_on
3.57	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
3.57	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
3.45	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
3.45	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
3.45	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
3.45	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
3.45	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
3.45	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.45	Single	6PT3	DPI-287	6PT3-δ-DPI-287
3.45	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
3.45	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
3.45	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.45	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
3.45	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
3.45	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
3.45	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
3.45	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
3.45	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
3.45	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
3.45	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
3.45	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
3.45	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
3.45	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
3.45	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
3.45	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
3.45	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
3.45	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.45	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.45	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
3.45	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
3.45	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
3.45	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
3.45	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
3.45	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
3.33	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
3.33	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
3.33	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
3.33	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.33	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
3.33	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
3.33	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.33	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
3.33	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.33	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
3.33	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
3.33	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
3.33	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
3.33	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
3.33	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.33	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
3.33	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
3.33	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
3.33	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
3.33	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
3.33	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
3.33	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
3.33	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
3.23	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
3.23	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
3.23	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
3.23	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
3.23	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.23	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.23	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
3.23	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
3.23	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.23	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
3.23	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
3.23	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
3.23	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
3.23	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
3.23	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
3.23	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
3.23	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
3.23	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
3.23	Consensus	sst_off	Orthosteric Ligand	sst2_off
3.12	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
3.12	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
3.12	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
3.12	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.12	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
3.12	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
3.12	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
3.12	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
3.12	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
3.12	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
3.12	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.12	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
3.12	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
3.12	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
3.12	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
3.12	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
3.12	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
3.12	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.12	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
3.12	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
3.12	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
3.03	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.03	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.03	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
3.03	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.03	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.03	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
3.03	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
3.03	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.03	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
3.03	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
3.03	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.03	Consensus	class-d_on	Orthosteric Ligand	ste2_on
3.03	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
3.03	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
3.03	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.03	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
3.03	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.03	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
2.94	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
2.94	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
2.94	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
2.94	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
2.94	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
2.94	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
2.94	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
2.94	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
2.94	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
2.94	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
2.94	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
2.94	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.94	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
2.94	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
2.94	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
2.94	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
2.94	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
2.94	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.94	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
2.94	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
2.94	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
2.94	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.94	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
2.94	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
2.86	Single	6FJ3	PTH	6FJ3-PTH1-PTH
2.86	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.86	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.86	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
2.86	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
2.86	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
2.86	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
2.86	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
2.86	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
2.86	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
2.86	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
2.86	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.86	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.86	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
2.86	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
2.86	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.86	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
2.86	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
2.86	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
2.78	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
2.78	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
2.78	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.78	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
2.78	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.78	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
2.78	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
2.78	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
2.78	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
2.78	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
2.78	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.78	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
2.78	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
2.78	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
2.70	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
2.70	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
2.70	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
2.70	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.70	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
2.70	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
2.70	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
2.70	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.70	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
2.70	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
2.70	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
2.70	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
2.70	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
2.70	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
2.70	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
2.70	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
2.70	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
2.63	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
2.63	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.63	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.63	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
2.63	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.56	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
2.56	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.56	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.56	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
2.56	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
2.50	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
2.50	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.50	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
2.50	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.50	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
2.44	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.44	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
2.44	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
2.44	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.44	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.44	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.44	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
2.44	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.44	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
2.44	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.38	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.38	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.38	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
2.38	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
2.27	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.27	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
2.27	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.22	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
2.17	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.13	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F492	R:R:R488	3.21	1	Yes	Yes	9	9	1	2
R:R:E586	R:R:R488	4.65	1	Yes	Yes	9	9	1	2
R:R:F492	R:R:Y496	8.25	1	Yes	Yes	9	9	1	2
R:R:E586	R:R:F492	16.32	1	Yes	Yes	9	9	1	1
R:R:F492	R:R:L590	3.65	1	Yes	No	9	9	1	2
R:R:E620	R:R:F492	5.83	1	Yes	Yes	9	9	2	1
R:R:F492	W:W:?1	3.84	1	Yes	Yes	9	0	1	0
R:R:E620	R:R:Y496	19.08	1	Yes	Yes	9	9	2	2
R:R:F589	R:R:T500	3.89	1	No	Yes	8	7	1	2
R:R:T500	R:R:W592	3.64	1	Yes	Yes	7	9	2	2
R:R:L501	R:R:M529	2.83	0	No	No	9	7	2	1
R:R:H504	R:R:K508	15.72	1	Yes	Yes	9	8	2	2
R:R:H504	R:R:Y520	2.18	1	Yes	Yes	9	8	2	2
R:R:H504	R:R:W592	3.17	1	Yes	Yes	9	9	2	2
R:R:H504	X:X:?2	6.98	1	Yes	Yes	9	0	2	1
R:R:K508	R:R:Y520	2.39	1	Yes	Yes	8	8	2	2
R:R:K508	X:X:?2	5.1	1	Yes	Yes	8	0	2	1
R:R:R525	R:R:Y520	4.12	0	No	Yes	6	8	1	2
R:R:M529	R:R:Y520	3.59	0	No	Yes	7	8	1	2
R:R:R525	R:R:R528	15.99	0	No	No	6	6	1	2
R:R:R525	W:W:?1	4.59	0	No	Yes	6	0	1	0
R:R:M529	W:W:?1	8.91	0	No	Yes	7	0	1	0
R:R:V532	W:W:?1	4.69	0	No	Yes	7	0	1	0
R:R:I533	W:W:?1	4.5	0	No	Yes	8	0	1	0
R:R:L535	W:W:?1	2.62	0	No	Yes	9	0	1	0
R:R:V536	W:W:?1	8.45	0	No	Yes	7	0	1	0
R:R:L541	R:R:V537	2.98	1	Yes	No	9	9	2	1
R:R:V537	W:W:?1	1.88	0	No	Yes	9	0	1	0
R:R:W539	S:S:W578	2.81	1	Yes	Yes	9	9	1	2
R:R:W539	S:S:M581	10.47	1	Yes	Yes	9	9	1	2
R:R:W539	S:S:T582	2.43	1	Yes	No	9	8	1	2
R:R:W539	S:S:A585	3.89	1	Yes	No	9	9	1	1
R:R:W539	W:W:?1	12.92	1	Yes	Yes	9	0	1	0
R:R:F540	R:R:W578	6.01	0	Yes	Yes	9	9	2	2
R:R:F540	X:X:?2	4.41	0	Yes	Yes	9	0	2	1
R:R:W578	S:S:W539	1.87	1	Yes	Yes	9	9	2	2
R:R:W578	S:S:F540	4.01	1	Yes	Yes	9	9	2	1
R:R:W578	S:S:W578	1.87	1	Yes	Yes	9	9	2	2
R:R:A585	S:S:W539	3.89	1	No	Yes	9	9	2	2
R:R:A585	X:X:?2	2.85	1	No	Yes	9	0	2	1
R:R:E586	R:R:H628	6.15	1	Yes	Yes	9	8	1	2
R:R:E586	W:W:?1	4.17	1	Yes	Yes	9	0	1	0
R:R:L588	X:X:?2	2.51	0	No	Yes	8	0	2	1
R:R:F589	R:R:W592	4.01	1	No	Yes	8	9	1	2
R:R:F589	W:W:?1	3.07	1	No	Yes	8	0	1	0
R:R:E620	R:R:L590	5.3	1	Yes	No	9	9	2	2
R:R:W592	X:X:?2	11.68	1	Yes	Yes	9	0	2	1
S:S:F540	S:S:L489	2.44	1	Yes	No	9	7	1	1
S:S:L489	S:S:L541	4.15	1	No	No	7	9	1	2
S:S:L489	W:W:?1	2.62	1	No	Yes	7	0	1	0
S:S:F492	X:X:?2	2.2	1	Yes	Yes	9	0	2	1
S:S:G497	S:S:T500	1.82	1	No	Yes	9	7	2	2
S:S:F589	S:S:G497	3.01	1	Yes	No	8	9	1	2
S:S:F589	S:S:T500	2.59	1	Yes	Yes	8	7	1	2
S:S:T500	S:S:W592	4.85	1	Yes	Yes	7	9	2	1
S:S:L501	S:S:M529	4.24	0	Yes	No	9	7	2	1
S:S:I533	S:S:L501	2.85	1	No	Yes	8	9	2	2
S:S:H504	S:S:K508	5.24	1	Yes	No	9	8	1	1
S:S:H504	S:S:W592	2.12	1	Yes	Yes	9	9	1	1
S:S:H504	S:S:L596	3.86	1	Yes	Yes	9	9	1	2
S:S:H504	W:W:?1	5.67	1	Yes	Yes	9	0	1	0
S:S:K508	S:S:Y520	8.36	1	No	Yes	8	8	1	2
S:S:K508	W:W:?1	5.33	1	No	Yes	8	0	1	0
S:S:M529	W:W:?1	3.56	1	No	Yes	7	0	1	0
S:S:M529	X:X:?2	9.38	1	No	Yes	7	0	1	1
S:S:V532	W:W:?1	1.88	1	No	Yes	7	0	1	0
S:S:V532	X:X:?2	4.49	1	No	Yes	7	0	1	1
S:S:F589	S:S:I533	2.51	1	Yes	No	8	8	1	2
S:S:I533	X:X:?2	3.44	1	No	Yes	8	0	2	1
S:S:L535	X:X:?2	2.51	0	No	Yes	9	0	2	1
S:S:V536	W:W:?1	1.88	1	No	Yes	7	0	1	0
S:S:V536	X:X:?2	5.39	1	No	Yes	7	0	1	1
S:S:V537	W:W:?1	1.88	0	No	Yes	9	0	1	0
S:S:W539	X:X:?2	11.68	1	Yes	Yes	9	0	2	1
S:S:F540	S:S:W544	3.01	1	Yes	Yes	9	9	1	2
S:S:F540	S:S:W578	9.02	1	Yes	Yes	9	9	1	2
S:S:F540	S:S:T582	2.59	1	Yes	No	9	8	1	2
S:S:F540	W:W:?1	3.84	1	Yes	Yes	9	0	1	0
S:S:W544	S:S:W578	6.56	1	Yes	Yes	9	9	2	2
S:S:M581	S:S:W578	2.33	1	Yes	Yes	9	9	2	2
S:S:L588	S:S:V584	2.98	0	No	No	8	6	1	2
S:S:A585	W:W:?1	3.97	1	No	Yes	9	0	1	0
S:S:L588	W:W:?1	2.62	0	No	Yes	8	0	1	0
S:S:F589	S:S:W592	5.01	1	Yes	Yes	8	9	1	1
S:S:F589	W:W:?1	5.37	1	Yes	Yes	8	0	1	0
S:S:F589	X:X:?2	2.2	1	Yes	Yes	8	0	1	1
S:S:L596	S:S:W592	9.11	1	Yes	Yes	9	9	2	1
S:S:W592	W:W:?1	10.76	1	Yes	Yes	9	0	1	0
W:W:?1	X:X:?2	30.51	1	Yes	Yes	0	0	0	1
R:R:A493	R:R:V537	1.7	0	No	No	8	9	2	1
S:S:A493	S:S:V537	1.7	0	No	No	8	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
89.47	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
77.78	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
73.68	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
38.46	Single	5KW2	PubChem 133053953	5KW2-FFA1 (GPR40)-PubChem 133053953
33.33	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
32.00	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
26.09	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
26.09	Consensus	c5a1_off_ortoallo	Other Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
25.00	Single	6OBA	GTPL11074	6OBA-β₂-(S)-Alprenolol-GTPL11074
25.00	Consensus	beta2_off_allo	Other Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
23.81	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
22.73	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
22.73	Consensus	d1_on_allo	Other Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
21.74	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
19.23	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
19.05	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	8IYX	YL-365	8IYX-GPR34-YL-365
14.81	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
14.81	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
14.29	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
14.29	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
14.29	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.79	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
13.79	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
13.79	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
13.04	Single	7LJD	Mevidalen	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
13.04	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
13.04	Single	7X2F	Mevidalen	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
13.04	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
12.90	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
12.90	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.90	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
12.50	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
12.50	Single	7LJC	Mevidalen	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
12.50	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
12.50	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
12.50	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
12.50	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.00	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
11.54	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
11.54	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
11.54	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
11.54	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
11.54	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
11.54	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
11.54	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
11.54	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
11.11	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
11.11	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
11.11	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
11.11	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
11.11	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
11.11	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.11	Consensus	class-d_on	Orthosteric Ligand	ste2_on
11.11	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
11.11	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
10.81	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
10.81	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.71	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
10.71	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
10.71	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
10.71	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
10.71	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
10.71	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
10.71	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
10.71	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
10.71	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
10.71	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
10.71	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.71	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
10.71	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
10.53	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
10.34	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
10.34	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
10.34	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
10.34	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.34	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
10.34	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
10.34	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
10.34	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
10.34	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
10.00	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
10.00	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
10.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
10.00	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
10.00	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
10.00	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
10.00	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
10.00	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
10.00	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
10.00	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
10.00	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
9.68	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
9.68	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
9.68	Consensus	class-d_off	Orthosteric Ligand	ste2_off
9.52	Single	8GEJ	Epinephrine	8GEJ-β₂-Epinephrine-Gs/&β;1/&γ;2
9.52	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
9.38	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
9.38	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.38	Single	7QA8	Peptide	7QA8-STE2-Peptide
9.38	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
9.38	Consensus	class-d_off	Orthosteric Ligand	ste2_off
9.09	Single	2HPY	All-trans-retinal	2HPY-Rhodopsin-All-trans-retinal
9.09	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
9.09	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8IWM	2-Phenylethylamine	8IWM-TAAR9-2-Phenylethylamine
9.09	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
8.70	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
8.70	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
8.70	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	8GGR	Epinephrine	8GGR-β₂-Epinephrine
8.70	Single	8GGZ	Epinephrine	8GGZ-β₂-Epinephrine
8.70	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
8.70	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.57	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
8.57	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
8.57	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.57	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.33	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
8.33	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
8.33	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
8.33	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
8.33	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
8.33	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
8.33	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2
8.33	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
8.33	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
8.33	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
8.33	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
8.33	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
8.33	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
8.33	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
8.33	Single	8GEI	Epinephrine	8GEI-β₂-Epinephrine-Gs/&β;1/&γ;2
8.33	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33	Single	8GGS	Epinephrine	8GGS-β₂-Epinephrine
8.33	Single	8GGY	Epinephrine	8GGY-β₂-Epinephrine
8.33	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
8.33	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
8.33	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
8.33	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.33	Single	8UNV	Epinephrine	8UNV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.33	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
8.33	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
8.33	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
8.33	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.11	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
8.11	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
8.11	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
8.11	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
8.11	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
8.00	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
8.00	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
8.00	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
8.00	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
8.00	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
8.00	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
8.00	Single	6AKX	A4R	6AKX-CCR5-A4R
8.00	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
8.00	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
8.00	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
8.00	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
8.00	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
8.00	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
8.00	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
8.00	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
8.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
8.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
8.00	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
8.00	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.00	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.00	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
8.00	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
8.00	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
8.00	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
8.00	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
8.00	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
8.00	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
8.00	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
8.00	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
8.00	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
8.00	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
8.00	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
8.00	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
8.00	Single	8GEC	Epinephrine	8GEC-β₂-Epinephrine-Gs/&β;1/&γ;2
8.00	Single	8GEF	Epinephrine	8GEF-β₂-Epinephrine-Gs/&β;1/&γ;2
8.00	Single	8GG7	Epinephrine	8GG7-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.00	Single	8GGA	Epinephrine	8GGA-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.00	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.00	Single	8GGV	Epinephrine	8GGV-β₂-Epinephrine
8.00	Single	8GGW	Epinephrine	8GGW-β₂-Epinephrine
8.00	Single	8GGX	Epinephrine	8GGX-β₂-Epinephrine
8.00	Single	8GH0	Epinephrine	8GH0-β₂-Epinephrine
8.00	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
8.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
8.00	Single	8UNO	Epinephrine	8UNO-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.00	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
8.00	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
8.00	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.00	Consensus	5ht2_on	Orthosteric Ligand	5ht2a_on 5ht2c_on
8.00	Consensus	5ht2c_on	Orthosteric Ligand	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
8.00	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
8.00	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
8.00	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
8.00	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
8.00	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
8.00	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
8.00	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
7.89	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
7.89	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
7.89	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
7.69	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
7.69	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
7.69	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
7.69	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
7.69	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
7.69	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
7.69	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
7.69	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
7.69	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
7.69	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
7.69	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
7.69	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
7.69	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
7.69	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
7.69	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
7.69	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
7.69	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
7.69	Single	6VI4	JDTic	6VI4-κ-JDTic
7.69	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
7.69	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
7.69	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
7.69	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
7.69	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
7.69	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
7.69	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
7.69	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
7.69	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
7.69	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
7.69	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
7.69	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
7.69	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
7.69	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
7.69	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
7.69	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
7.69	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
7.69	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
7.69	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
7.69	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
7.69	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
7.69	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
7.69	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
7.69	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GE1	Epinephrine	8GE1-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GE4	Epinephrine	8GE4-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GE6	Epinephrine	8GE6-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GE7	Epinephrine	8GE7-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GE8	Epinephrine	8GE8-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GE9	Epinephrine	8GE9-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
7.69	Single	8GFV	Epinephrine	8GFV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69	Single	8GG4	Epinephrine	8GG4-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69	Single	8GGI	Epinephrine	8GGI-β₂-Epinephrine
7.69	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
7.69	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
7.69	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
7.69	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
7.69	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
7.69	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
7.69	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
7.69	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
7.69	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
7.69	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
7.69	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
7.69	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
7.69	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
7.69	Single	8UNQ	Epinephrine	8UNQ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.69	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
7.69	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
7.69	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
7.69	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
7.69	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
7.69	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
7.69	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
7.69	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
7.69	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
7.69	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
7.69	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
7.69	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
7.69	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
7.69	Consensus	sensory_off	Orthosteric Ligand	opsin_off
7.50	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
7.41	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
7.41	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
7.41	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
7.41	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
7.41	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
7.41	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
7.41	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
7.41	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
7.41	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
7.41	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
7.41	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
7.41	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
7.41	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
7.41	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
7.41	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
7.41	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
7.41	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
7.41	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
7.41	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
7.41	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
7.41	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
7.41	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
7.41	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
7.41	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
7.41	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
7.41	Single	6PS1	Timolol	6PS1-β₂-Timolol
7.41	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
7.41	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
7.41	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
7.41	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
7.41	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
7.41	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
7.41	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
7.41	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.41	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
7.41	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
7.41	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
7.41	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
7.41	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
7.41	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
7.41	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
7.41	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
7.41	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
7.41	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
7.41	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
7.41	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
7.41	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
7.41	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
7.41	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
7.41	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
7.41	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
7.41	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
7.41	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
7.41	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
7.41	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
7.41	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
7.41	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
7.41	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
7.41	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
7.41	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
7.41	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
7.41	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
7.41	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
7.41	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
7.41	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
7.41	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
7.41	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
7.41	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.41	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.41	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
7.41	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
7.41	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
7.41	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
7.41	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
7.41	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
7.41	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
7.41	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
7.41	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
7.41	Consensus	adgrf1_on_allo	Other Ligand	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
7.41	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
7.41	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
7.41	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
7.41	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
7.41	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
7.41	Consensus	blt_on	Orthosteric Ligand	blt1_on
7.41	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
7.41	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
7.41	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
7.41	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
7.41	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
7.41	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
7.41	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
7.41	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
7.41	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
7.41	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
7.41	Consensus	leuko_on	Orthosteric Ligand	blt_on
7.41	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
7.41	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
7.41	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.41	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
7.41	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
7.41	Consensus	tar_on	Orthosteric Ligand	ta1_on
7.32	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
7.32	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
7.32	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
7.14	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
7.14	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
7.14	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
7.14	Single	5C1M	BU72	5C1M-μ-BU72
7.14	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
7.14	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
7.14	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
7.14	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
7.14	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
7.14	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
7.14	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
7.14	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
7.14	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
7.14	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
7.14	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
7.14	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
7.14	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
7.14	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
7.14	Single	6PS6	Timolol	6PS6-β₂-Timolol
7.14	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
7.14	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
7.14	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
7.14	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
7.14	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
7.14	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
7.14	Single	7C4S	S1P	7C4S-S1P₃-S1P
7.14	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
7.14	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
7.14	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
7.14	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
7.14	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
7.14	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
7.14	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
7.14	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
7.14	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
7.14	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
7.14	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
7.14	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
7.14	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
7.14	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
7.14	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
7.14	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
7.14	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
7.14	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
7.14	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
7.14	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
7.14	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
7.14	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.14	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
7.14	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
7.14	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
7.14	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
7.14	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
7.14	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
7.14	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
7.14	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
7.14	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
7.14	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
7.14	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
7.14	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
7.14	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
7.14	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
7.14	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
7.14	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
7.14	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
7.14	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
7.14	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
7.14	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
7.14	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
7.14	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
7.14	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.98	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
6.98	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
6.90	Single	2YDV	NECA	2YDV-A_2A-NECA
6.90	Single	3P0G	BI167107	3P0G-β₂-BI167107
6.90	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
6.90	Single	4DJH	JDTic	4DJH-κ-JDTic
6.90	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
6.90	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
6.90	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
6.90	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
6.90	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
6.90	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
6.90	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
6.90	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
6.90	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
6.90	Single	5G53	NECA	5G53-A_2A-NECA-Gs
6.90	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
6.90	Single	5XR8	AM841	5XR8-CB₁-AM841
6.90	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
6.90	Single	6E59	L-760735	6E59-NK₁-L-760735
6.90	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
6.90	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
6.90	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
6.90	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
6.90	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
6.90	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
6.90	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
6.90	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
6.90	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
6.90	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
6.90	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
6.90	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
6.90	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
6.90	Single	7EPE	NAM563	7EPE-mGlu-NAM563
6.90	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
6.90	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
6.90	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
6.90	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
6.90	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
6.90	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
6.90	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
6.90	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
6.90	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
6.90	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
6.90	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
6.90	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
6.90	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
6.90	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
6.90	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
6.90	Single	8E0G	BU72	8E0G-μ-BU72
6.90	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
6.90	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
6.90	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
6.90	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
6.90	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
6.90	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
6.90	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
6.90	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
6.90	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
6.90	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
6.90	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.90	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
6.90	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
6.90	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
6.90	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
6.90	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
6.90	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
6.90	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
6.90	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
6.90	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
6.90	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
6.90	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
6.90	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.90	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
6.90	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
6.90	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
6.90	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
6.90	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
6.90	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
6.90	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
6.90	Consensus	histamine_off	Orthosteric Ligand	h1_off
6.90	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
6.90	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
6.90	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
6.90	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
6.90	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
6.90	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
6.82	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
6.82	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
6.67	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
6.67	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
6.67	Single	4LDE	BI167107	4LDE-β₂-BI167107
6.67	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
6.67	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
6.67	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
6.67	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
6.67	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
6.67	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
6.67	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
6.67	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
6.67	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
6.67	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
6.67	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
6.67	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
6.67	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.67	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
6.67	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
6.67	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
6.67	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
6.67	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
6.67	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.67	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
6.67	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
6.67	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
6.67	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
6.67	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
6.67	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
6.67	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
6.67	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
6.67	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
6.67	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
6.67	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
6.67	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
6.67	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
6.67	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
6.67	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
6.67	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
6.67	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
6.67	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
6.67	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
6.67	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
6.67	Consensus	gi_class-f	Other Ligand	gi_frizzled
6.67	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.67	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
6.67	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
6.67	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
6.67	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
6.67	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
6.67	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
6.67	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
6.67	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
6.67	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
6.67	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.52	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
6.52	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.45	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
6.45	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
6.45	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
6.45	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
6.45	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
6.45	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
6.45	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
6.45	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
6.45	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
6.45	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
6.45	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
6.45	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
6.45	Single	7EZC	UKA	7EZC-A_2A-UKA
6.45	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
6.45	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.45	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
6.45	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
6.45	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
6.45	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
6.45	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
6.45	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
6.45	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
6.45	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
6.45	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.45	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
6.45	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
6.45	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
6.45	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
6.45	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
6.45	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.45	Consensus	endothelin_off	Orthosteric Ligand	etb_off
6.45	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
6.45	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.45	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
6.45	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.45	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45	Consensus	orexin_on	Orthosteric Ligand	ox2_on
6.25	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
6.25	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
6.25	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
6.25	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
6.25	Single	6PT3	DPI-287	6PT3-δ-DPI-287
6.25	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
6.25	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
6.25	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
6.25	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
6.25	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
6.25	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
6.25	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
6.25	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
6.25	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
6.25	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
6.25	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
6.25	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
6.25	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
6.25	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
6.12	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
6.06	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
6.06	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
6.06	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
6.06	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
6.06	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
6.06	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
6.06	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
6.06	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.06	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
6.06	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
6.06	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
6.06	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
6.06	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
6.06	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.06	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
6.06	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
6.06	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
6.06	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
6.06	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
6.06	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
5.88	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
5.88	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
5.88	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
5.88	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
5.88	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.88	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.88	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
5.88	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
5.88	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
5.88	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
5.71	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
5.71	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.71	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
5.71	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
5.71	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
5.71	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
5.71	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
5.71	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.71	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.71	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.71	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
5.71	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.71	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.71	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
5.71	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.71	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.56	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
5.56	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
5.56	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.56	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
5.56	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.56	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	class-c_off	Other Ligand	gabab_off mglu_off
5.56	Consensus	class-d_on	Orthosteric Ligand	ste2_on
5.56	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
5.56	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.56	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.56	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.41	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
5.41	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
5.41	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.41	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
5.41	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
5.41	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
5.41	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
5.41	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
5.41	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
5.41	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.41	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
5.41	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
5.26	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
5.26	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.26	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
5.26	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
5.26	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.13	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
5.13	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
5.13	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
5.13	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
5.13	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.13	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
5.13	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.13	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
5.13	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
5.13	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
5.13	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
5.13	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
5.13	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.00	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
5.00	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
5.00	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
5.00	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
5.00	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
5.00	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
5.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
5.00	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
5.00	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.88	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.88	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
4.88	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
4.88	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.88	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
4.88	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
4.76	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
4.76	Single	8WCC	Cyclohexylammonium ion	8WCC-TA1-Cyclohexylammonium ion
4.76	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
4.65	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
4.65	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	5XSZ	Glyceryl Mono-oleate	5XSZ-LPA₆-Glyceryl Mono-oleate
4.55	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
4.55	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
4.55	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.55	Consensus	gabab_off	Other Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
4.55	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
4.55	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
4.55	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
4.55	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
4.55	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
4.44	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
4.44	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
4.35	Single	6KQI	ORG27569	6KQI-CB₁-PubMed 104895-ORG27569
4.35	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
4.35	Single	7MTB	All-trans-retinal	7MTB-Rhodopsin-All-trans-retinal-GRK1
4.35	Single	8WC5	Tetramethylammonium ion	8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	cb1_off_allo	Other Ligand	6KQI-CB₁-PubMed 104895-ORG27569
4.35	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.26	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
4.17	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
4.17	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
4.17	Single	3PQR	All-trans-retinal	3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
4.17	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
4.17	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
4.17	Single	6FUF	All-trans-retinal	6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
4.17	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
4.17	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
4.17	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
4.17	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
4.17	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
4.17	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
4.17	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
4.17	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
4.17	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
4.17	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
4.17	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.17	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/&β;1/&γ;2
4.17	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
4.17	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
4.00	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
4.00	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
4.00	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
4.00	Single	6HLL	CP99994	6HLL-NK₁-CP99994
4.00	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
4.00	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
4.00	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
4.00	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
4.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
4.00	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
4.00	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
4.00	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
4.00	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
4.00	Single	8ITF	DMCHA	8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
4.00	Single	8J6Q	Compound 9n	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.00	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.00	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
4.00	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
4.00	Single	8UNX	Epinephrine	8UNX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.00	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
4.00	Consensus	hca2_on_allo	Other Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.00	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
4.00	Consensus	mt2_on	Orthosteric Ligand	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
3.85	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
3.85	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
3.85	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
3.85	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
3.85	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
3.85	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
3.85	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
3.85	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
3.85	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
3.85	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
3.85	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.85	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
3.85	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
3.85	Single	8G94	CD69	8G94-S1P₁-CD69-Gi1/&β;1/&γ;2
3.85	Single	8GEA	Epinephrine	8GEA-β₂-Epinephrine-Gs/&β;1/&γ;2
3.85	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
3.85	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.85	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
3.85	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
3.85	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
3.85	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
3.85	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
3.85	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
3.85	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.85	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2
3.85	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.85	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.85	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.85	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.85	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
3.85	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
3.85	Consensus	alpha2a_off	Orthosteric Ligand	6KUX-α_2a-RS-79948
3.85	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
3.85	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
3.85	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
3.85	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
3.85	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.70	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
3.70	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
3.70	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
3.70	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
3.70	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
3.70	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
3.70	Single	6IQL	L745870	6IQL-D₄-L745870
3.70	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
3.70	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
3.70	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
3.70	Single	6TPG	EMPA	6TPG-OX₂-EMPA
3.70	Single	6TPK	Retosiban	6TPK-OT-Retosiban
3.70	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
3.70	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
3.70	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
3.70	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
3.70	Single	7T32	ZM241385	7T32-A_2A-ZM241385
3.70	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
3.70	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.70	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.70	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
3.70	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
3.70	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.70	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
3.70	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
3.70	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
3.70	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
3.70	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.70	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.70	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
3.70	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
3.70	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
3.70	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
3.70	Consensus	hcar_on	Orthosteric Ligand	hca_on
3.70	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
3.70	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
3.70	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
3.57	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
3.57	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
3.57	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
3.57	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
3.57	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
3.57	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
3.57	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
3.57	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
3.57	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
3.57	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
3.57	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
3.57	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
3.57	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
3.57	Single	6GPS	MK0812	6GPS-CCR2-MK0812
3.57	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
3.57	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
3.57	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
3.57	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
3.57	Single	7BU7	BI167107	7BU7-β₁-BI167107
3.57	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
3.57	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
3.57	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
3.57	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
3.57	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
3.57	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
3.57	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
3.57	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
3.57	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
3.57	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
3.57	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
3.57	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
3.57	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.57	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
3.57	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
3.57	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
3.57	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
3.57	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
3.57	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
3.57	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.57	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
3.57	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
3.57	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
3.57	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
3.57	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
3.57	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
3.45	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
3.45	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
3.45	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
3.45	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
3.45	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
3.45	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
3.45	Single	5WQC	EMPA	5WQC-OX₂-EMPA
3.45	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
3.45	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
3.45	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
3.45	Single	6GPX	MK0812	6GPX-CCR2-MK0812
3.45	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
3.45	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
3.45	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
3.45	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
3.45	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
3.45	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
3.45	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
3.45	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
3.45	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
3.45	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
3.45	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
3.45	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
3.45	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
3.45	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
3.45	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
3.45	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
3.45	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
3.45	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
3.45	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
3.45	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.33	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
3.33	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
3.33	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
3.33	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
3.33	Single	5X93	K-8794	5X93-ET_B-K-8794
3.33	Single	5XRA	AM11542	5XRA-CB₁-AM11542
3.33	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
3.33	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
3.33	Single	6OS1	TRV026	6OS1-AT₁-TRV026
3.33	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
3.33	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
3.33	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
3.33	Single	7P2L	4YI	7P2L-mGlu₅-4YI
3.33	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
3.33	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
3.33	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
3.33	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
3.33	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
3.33	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
3.33	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
3.33	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
3.33	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.33	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
3.33	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
3.33	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
3.33	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
3.33	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
3.33	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
3.33	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
3.33	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.33	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
3.33	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
3.33	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
3.33	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
3.33	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
3.33	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
3.33	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
3.33	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
3.33	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
3.33	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
3.33	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
3.23	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
3.23	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
3.23	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
3.23	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
3.23	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
3.23	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
3.23	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
3.23	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
3.23	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.23	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.23	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
3.23	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
3.23	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.23	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
3.23	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
3.23	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
3.23	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
3.23	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
3.23	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
3.23	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
3.23	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
3.23	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
3.23	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
3.23	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
3.23	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
3.23	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
3.23	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
3.23	Consensus	dp_off	Orthosteric Ligand	dp2_off
3.23	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
3.23	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
3.23	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
3.23	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
3.23	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
3.12	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
3.12	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
3.12	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
3.12	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
3.12	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
3.12	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
3.12	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
3.12	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
3.12	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
3.12	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
3.12	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
3.12	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
3.12	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
3.12	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.12	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
3.12	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
3.12	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
3.12	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.12	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
3.12	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
3.03	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
3.03	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
3.03	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
3.03	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
3.03	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
3.03	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
3.03	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.03	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
3.03	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
3.03	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
3.03	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
3.03	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
3.03	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
3.03	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
3.03	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
3.03	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.03	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
3.03	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.94	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
2.94	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
2.94	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
2.94	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
2.94	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
2.94	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
2.94	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
2.94	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
2.94	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
2.94	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.94	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
2.94	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
2.86	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
2.86	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
2.86	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
2.86	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.86	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
2.86	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
2.86	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
2.86	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.86	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
2.86	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
2.86	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
2.86	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
2.86	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
2.86	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
2.86	Consensus	sst_off	Orthosteric Ligand	sst2_off
2.78	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
2.78	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
2.78	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
2.78	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
2.78	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
2.78	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
2.78	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
2.78	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
2.78	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
2.78	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
2.78	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.78	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
2.78	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
2.78	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
2.70	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
2.70	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
2.70	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
2.70	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
2.70	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
2.70	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
2.70	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
2.70	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
2.70	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.70	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
2.70	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
2.70	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
2.63	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
2.63	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
2.63	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.63	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
2.63	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
2.63	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
2.63	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
2.63	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
2.63	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.63	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
2.63	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
2.63	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
2.63	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
2.63	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
2.63	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.63	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.63	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.63	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.63	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
2.56	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
2.56	Single	6FJ3	PTH	6FJ3-PTH1-PTH
2.56	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.56	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
2.56	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
2.56	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.56	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
2.56	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.56	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
2.56	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.56	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
2.56	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
2.56	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
2.56	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
2.56	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.56	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
2.50	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
2.50	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
2.50	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
2.50	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
2.50	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.50	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
2.50	Consensus	go_class-b1	Orthosteric Ligand	go_crf
2.50	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
2.44	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.44	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.44	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
2.44	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
2.44	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
2.44	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
2.44	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
2.44	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
2.44	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
2.44	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
2.44	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.44	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
2.38	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
2.38	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
2.38	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.38	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
2.38	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.38	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.33	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
2.33	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.33	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.33	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
2.27	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
2.27	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
2.27	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.27	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
2.22	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.22	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.22	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.22	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.13	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.04	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.00	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.00	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
1.96	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1

PDB Summary
PDB	7SHE
Class	C
SubFamily	Orphan
Type	C orphans
SubType	GPR158
Species	Homo sapiens
Ligand	-
Other Ligand(s)	PI; PE
Protein Partners	-
PDB Resolution	3.4
Date	2021-12-01
D.O.I.	10.1126/science.abl4732

Net Summary
I_min	1.82
Number of Linked Nodes	1022
Number of Links	1259
Number of Hubs	199
Number of Links mediated by Hubs	726
Number of Communities	33
Number of Nodes involved in Communities	301
Number of Links involved in Communities	442

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	8319024
Length Of Smallest Path	3
Average Path Length	51.8476
Length of Longest Path	84
Minimum Path Strength	1.21
Average Path Strength	5.88324
Maximum Path Strength	36.26
Minimum Path Correlation	0.7
Average Path Correlation	0.997707
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2
Average % Of Corr. Nodes	45.6892
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.3483
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PEE
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	PEE
Name	Phosphatidylethanolamine
Synonyms	DOPE
Identifier	[(2~{R})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-[(~{Z})-octadec-9-enoyl]oxy-propyl] (~{Z})-octadec-9-enoate
Formula	C41 H78 N O8 P
Molecular Weight	744.034
SMILES	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CCCCCCC/C=C\CCCCCCCC
PubChem	44251425
Formal Charge	0
Total Atoms	129
Total Chiral Atoms	1
Total Bonds	128
Total Aromatic Bonds	0


Code	EIJ
PDB Residues	X:X:?2
Environment Details	Open EMBL-EBI Page
Code	EIJ
Name	(2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate
Synonyms
Identifier	[(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(2~{S},3~{S},5~{R},6~{R})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (5~{E},8~{E},11~{E},14~{E})-icosa-5,8,11,14-tetraenoate
Formula	C47 H83 O13 P
Molecular Weight	887.128
SMILES	CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](COP(=O)(O)OC1[C@H]([C@H](C([C@H]([C@H]1O)O)O)O)O)OC(=O)CCC/C=C/C/C=C/C/C=C/C/C=C/CCCCC
PubChem
Formal Charge	0
Total Atoms	144
Total Chiral Atoms	5
Total Bonds	144
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5T848
Sequence	>7SHE_Chain_R D G T I L A Q K L A E E V P M D V A S Y L Y T G D S H Q L K R A N C S G R Y E L A G L P G K W P A L A S A H P S L H R A L D T L T H A T N F L N V M L Q S N K S R E Q N L Q D D L D W Y Q A L V W S L L E G E P S I S R A A I T F S T A P Q V F L Q A T R E E S R I L L Q D D K S H F K W S P P Y L E C E N G S Y K P G W L V T L S S A I Y G L P E F R G V M K V D I N L Q K V D I D Q C S S D G W F S G T H K C H L N N S E C M P I K G L G F V L G A Y E C I C K A G F Y H P G V L P V N N F R R R G P D Q H I S G S T K D V S E E A Y V C L P C R E G C P F C A D D S P C F V Q E D K Y L R L A I I S F Q A L C M L L D F V S M L V V Y H F R K A K S I R A S G L I L L E T I L F G S L L L Y F P V V I L Y F E P S T F R C I L L R W A R L L G F A T V Y G T V T L K L H R V L K V F L S R T A Q R I P Y M T G G R V M R M L A V I L L V V F W F L I G W T S S V C Q N L E K Q I S L I G Q G K T S D H L I F N M C L I D R W D Y M T A V A E F L F L L W G V Y L C Y A V R T V P S A F H E P R Y M A V A V H N E L I I S A I F H T I R F V L A S R L Q S D W M L M L Y F A H T H L T V T V T I G L L L I P K F S H S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	Q5T848
Sequence	>7SHE_Chain_S D G T I L A Q K L A E E V P M D V A S Y L Y T G D S H Q L K R A N C S G R Y E L A G L P G K W P A L A S A H P S L H R A L D T L T H A T N F L N V M L Q S N K S R E Q N L Q D D L D W Y Q A L V W S L L E G E P S I S R A A I T F S T A P Q V F L Q A T R E E S R I L L Q D D K S H F K W S P P Y L E C E N G S Y K P G W L V T L S S A I Y G L Q P E F R G V M K V D I N L Q K V D I D Q C S S D G W F S G T H K C H L N N S E C M P I K G L G F V L G A Y E C I C K A G F Y H P G V L P V N N F R R R G P D Q H I S G S T K D V S E E A Y V C L P C R E G C P F C A D D S P C F V Q E D K Y L R L A I I S F Q A L C M L L D F V S M L V V Y H F R K A K S I R A S G L I L L E T I L F G S L L L Y F P V V I L Y F E P S T F R C I L L R W A R L L G F A T V Y G T V T L K L H R V L K V F L S R T A Q R I P Y M T G G R V M R M L A V I L L V V F W F L I G W T S S V C Q N L E K Q I S L I G Q G K T S D H L I F N M C L I D R W D Y M T A V A E F L F L L W G V Y L C Y A V R T V P S A F H E P R Y M A V A V H N E L I I S A I F H T I R F V L A S R L Q S D W M L M L Y F A H T H L T V T V T I G L L L I P K F S H S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7EWL	C	Orphan	C orphans	GPR158	Homo sapiens	-	-	-	3.52	2021-12-01	10.1038/s41467-021-27147-1
	7EWP	C	Orphan	C orphans	GPR158	Homo sapiens	-	-	B5; RGS7	4.3	2021-12-01	10.1038/s41467-021-27147-1
	7EWR	C	Orphan	C orphans	GPR158	Homo sapiens	-	-	B5; RGS7	4.7	2021-12-01	10.1038/s41467-021-27147-1
	7SHE	C	Orphan	C orphans	GPR158	Homo sapiens	-	PI; PE	-	3.4	2021-12-01	10.1126/science.abl4732
	7SHF	C	Orphan	C orphans	GPR158	Homo sapiens	-	PI; PE	B5; RGS7	3.4	2021-12-01	10.1126/science.abl4732

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