Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:K95 9.9975412
2R:R:L126 3.6025404
3R:R:L129 5.08254116
4R:R:Q148 4.15406
5R:R:W156 15.9783679
6R:R:W162 9.3654157
7R:R:E168 4.20286798
8R:R:R173 7.21617
9R:R:Q193 8.12408
10R:R:I201 8.9725159
11R:R:H212 12.0833613
12R:R:Y269 6.485415
13R:R:E271 8.2225418
14R:R:Y277 12.3175408
15R:R:K278 6.845415
16R:R:W281 7.80667629
17R:R:L282 6.435417
18R:R:T284 6.11667618
19R:R:I289 2.66408
20R:R:V303 3.44519
21R:R:M304 5.07754117
22R:R:K305 9.53618
23R:R:D307 7.256519
24R:R:I308 5.13667696
25R:R:L310 7.58498
26R:R:Q317 5.824529
27R:R:C318 5.085429
28R:R:F324 5.8275429
29R:R:N334 2.67407
30R:R:Y350 5.88143729
31R:R:Y359 4.5875429
32R:R:R417 5.296676219
33R:R:F423 5.84465
34R:R:S450 4.8085129
35R:R:Y466 4.836568
36R:R:W486 7.375409
37R:R:R488 6.094549
38R:R:F492 11.026549
39R:R:Y496 9.235449
40R:R:K502 4.70254129
41R:R:L503 2.98508
42R:R:W544 7.3875409
43R:R:I559 2.0225408
44R:R:K563 4.1185244
45R:R:I575 4.112546
46R:R:R577 6.006508
47R:R:W578 7.308509
48R:R:V600 2.74754239
49R:R:V603 4.52254239
50R:R:E609 6.20754129
51R:R:E620 6.50167649
52R:R:F627 14.415409
53R:R:H628 6.39333648
54R:R:F632 6.676549
55R:R:L634 3.56405
56R:R:Y647 8.58405
57R:R:F648 6.195469
58R:R:H652 7.59569
59R:R:T654 4.78409
60R:R:V655 3.95833667
61R:R:I659 3.1125467
62R:R:L663 2.45408
63S:S:Y87 10.5054106
64S:S:R96 13.7765103
65S:S:F135 6.7375408
66S:S:L136 3.408579
67S:S:M139 6.97407
68S:S:L140 3.5875478
69S:S:D153 10.1479
70S:S:W156 15.1717679
71S:S:Y157 6.796579
72S:S:W162 10.95254147
73S:S:F178 8.06476
74S:S:Q193 6.564138
75S:S:I201 8.5554149
76S:S:L203 9.02754149
77S:S:L213 5.245406
78S:S:F263 7.0325406
79S:S:L270 13.414109
80S:S:Y277 16.7354108
81S:S:P279 3.754109
82S:S:W281 10.892509
83S:S:I289 4.0575478
84S:S:M304 3.846507
85S:S:K305 4.99254138
86S:S:I308 4.466166
87S:S:L310 5.10254168
88S:S:Q317 3.405459
89S:S:W323 2.432509
90S:S:F324 4.05559
91S:S:P339 4.7325458
92S:S:Y350 4.19333659
93S:S:C395 2.65754259
94S:S:R417 6.2425179
95S:S:F423 4.575485
96S:S:D431 4.365406
97S:S:S450 6.344189
98S:S:E456 3.2825409
99S:S:Y466 4.20333688
100S:S:Y473 5.805408
101S:S:I482 2.9075407
102S:S:W486 8.765409
103S:S:R488 5.2539
104S:S:F492 10.68539
105S:S:Y496 10.982539
106S:S:F540 3.5125439
107S:S:W544 6.775639
108S:S:K563 4.19404
109S:S:R577 5.395408
110S:S:W578 7.64167639
111S:S:E586 9.005439
112S:S:L590 3.49439
113S:S:L596 2.48409
114S:S:E609 6.254189
115S:S:E620 8.16539
116S:S:F627 8.88539
117S:S:H628 5.09638
118S:S:F632 7.9575439
119S:S:Y647 6.084535
120S:S:H652 7.442589
121S:S:T654 5.48409
122S:S:V655 3.95833687
123S:S:I659 3.1125487
124S:S:L663 2.6825408
125S:S:K666 6.5554189
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:K305 R:R:V303 10.43823.04YesYes189
2R:R:G302 R:R:V303 10.59491.84NoYes099
3R:R:G302 R:R:I289 10.60543.53NoYes098
4R:R:I289 R:R:L136 10.72312.85YesNo089
5R:R:L136 R:R:L160 10.71934.15NoNo099
6R:R:F135 R:R:L160 10.71522.44NoNo089
7R:R:R417 R:R:Y473 24.65610.29YesNo098
8R:R:L644 R:R:R417 38.08464.86NoYes099
9R:R:I420 R:R:L644 40.32142.85NoNo089
10R:R:F648 R:R:I420 42.557710.05YesNo098
11R:R:I421 R:R:Y473 20.176610.88NoNo078
12R:R:I421 R:R:V470 17.93633.07NoNo077
13R:R:F423 R:R:F648 15.67764.29YesYes659
14R:R:C427 R:R:F423 17.16174.19NoYes685
15R:R:C427 R:R:H652 17.16215.9NoYes689
16R:R:F648 R:R:H652 31.35139.05YesYes699
17R:R:H652 R:R:Q424 17.16743.71YesNo099
18R:R:C427 R:R:Y466 35.06082.69NoYes688
19R:R:Q424 R:R:Y466 18.64956.76NoYes098
20R:R:V655 R:R:Y466 56.61845.05YesYes678
21R:R:I659 R:R:V655 12.06833.07YesYes677
22R:R:S462 R:R:V655 10.55973.23NoYes697
23R:R:T654 R:R:V655 80.51284.76YesYes097
24R:R:E620 R:R:T654 42.48397.06YesYes099
25R:R:E620 R:R:R488 24.39372.33YesYes499
26R:R:H628 R:R:R488 48.94236.77YesYes489
27R:R:F632 R:R:H628 1006.79YesYes498
28R:R:D579 R:R:F632 54.67272.39NoYes499
29R:R:D579 R:R:R485 55.34811.91NoNo099
30R:R:R485 R:R:W544 55.338313.99NoYes099
31R:R:I482 R:R:W544 11.17254.7NoYes079
32R:R:I482 R:R:W486 10.99312.35NoYes079
33R:R:L541 R:R:W486 20.500817.08NoYes099
34R:R:L541 R:R:V537 19.93392.98NoNo099
35R:R:A493 R:R:V537 19.56061.7NoNo089
36R:R:A493 R:R:I533 18.81291.62NoNo088
37R:R:F589 R:R:I533 18.43842.51NoNo088
38R:R:F589 R:R:G497 10.38643.01NoNo089
39R:R:G497 R:R:L530 10.0041.71NoNo099
40R:R:H650 R:R:T654 42.43842.74NoYes099
41R:R:H650 R:R:R488 21.29712.26NoYes099
42R:R:E620 R:R:S624 24.31524.31YesNo099
43R:R:H628 R:R:S624 24.47428.37YesNo089
44R:R:F627 R:R:H650 21.710329.41YesNo099
45R:R:F627 R:R:H628 23.36235.66YesYes098
46R:R:T545 R:R:W544 11.17252.43NoYes099
47R:R:T545 R:R:W486 10.99316.06NoYes099
48R:R:I471 R:R:V470 15.69561.54NoNo097
49R:R:W578 S:S:W578 94.77468.43YesYes099
50R:R:W544 R:R:W578 51.6878.43YesYes099
51R:R:D576 R:R:W578 43.53615.58NoYes089
52R:R:D576 R:R:R577 44.40772.38NoYes088
53R:R:R577 R:R:Y580 46.66264.12YesNo088
54R:R:F632 R:R:Y580 46.093312.38YesNo498
55S:S:F540 S:S:W578 66.98264.01YesYes399
56S:S:F540 S:S:L489 49.70532.44YesNo397
57S:S:L489 S:S:R488 49.48752.43NoYes379
58S:S:H650 S:S:R488 34.8256.77NoYes099
59S:S:H650 S:S:T654 31.73196.85NoYes099
60S:S:T654 S:S:V655 31.02394.76YesYes097
61S:S:V655 S:S:Y466 20.82415.05YesYes878
62S:S:F492 S:S:R488 11.03785.34YesYes399
63S:S:F492 S:S:Y496 17.47717.54YesYes399
64S:S:V495 S:S:Y496 16.72738.83NoYes089
65S:S:I458 S:S:V495 16.13524.61NoNo098
66S:S:I458 S:S:T498 12.57453.04NoNo099
67S:S:L454 S:S:T498 11.97965.9NoNo099
68S:S:K502 S:S:L454 10.19285.64NoNo099
69S:S:F540 S:S:T582 15.53032.59YesNo398
70S:S:E586 S:S:T582 15.30994.23YesNo398
71S:S:E586 S:S:F492 10.96919.82YesYes399
72S:S:W544 S:S:W578 27.74169.37YesYes399
73S:S:I482 S:S:W544 15.33264.7YesYes079
74S:S:I482 S:S:W486 12.34562.35YesYes079
75S:S:T545 S:S:W544 12.57313.64NoYes099
76S:S:T545 S:S:W486 12.27446.06NoYes099
77S:S:F627 S:S:H628 11.98892.26YesYes398
78S:S:F627 S:S:Y647 10.067710.32YesYes395
79S:S:L541 S:S:W486 17.909821.64NoYes099
80S:S:L541 S:S:V537 17.29782.98NoNo099
81S:S:A493 S:S:V537 16.68531.7NoNo089
82S:S:A493 S:S:I533 16.07251.62NoNo088
83S:S:F589 S:S:I533 15.45932.51NoNo088
84S:S:F589 S:S:W592 12.38713.01NoNo089
85S:S:T500 S:S:W592 11.77154.85NoNo079
86S:S:G593 S:S:T500 11.15553.64NoNo077
87S:S:G593 S:S:L596 10.53911.71NoYes079
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EWL
Class C
SubFamily Orphan
Type Orphan
SubType GPR158
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.52
Date 2021-12-01
D.O.I. 10.1038/s41467-021-27147-1
Net Summary
Imin 1.84
Number of Linked Nodes 897
Number of Links 1005
Number of Hubs 125
Number of Links mediated by Hubs 466
Number of Communities 25
Number of Nodes involved in Communities 185
Number of Links involved in Communities 256
Path Summary
Number Of Nodes in MetaPath 88
Number Of Links MetaPath 87
Number of Shortest Paths 754698
Length Of Smallest Path 3
Average Path Length 23.8223
Length of Longest Path 59
Minimum Path Strength 1.195
Average Path Strength 5.82605
Maximum Path Strength 37.405
Minimum Path Correlation 0.7
Average Path Correlation 0.987337
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 6.25
Average % Of Corr. Nodes 61.6653
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.2544
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus   • regulation of cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • regulation of localization   • cellular localization   • transport   • modulation of chemical synaptic transmission   • positive regulation of neurotransmitter secretion   • positive regulation of biological process   • positive regulation of secretion by cell   • localization   • synaptic signaling   • regulation of secretion by cell   • secretion by cell   • positive regulation of secretion   • signal release   • establishment of localization in cell   • positive regulation of cellular process   • trans-synaptic signaling   • positive regulation of neurotransmitter transport   • neurotransmitter secretion   • regulation of transport   • secretion   • regulation of neurotransmitter transport   • export from cell   • cell-cell signaling   • positive regulation of synaptic transmission   • neurotransmitter transport   • establishment of localization   • regulation of secretion   • chemical synaptic transmission   • signal release from synapse   • regulation of trans-synaptic signaling   • positive regulation of transport   • regulation of neurotransmitter secretion   • anterograde trans-synaptic signaling   • positive regulation of signaling   • protein localization   • protein localization to cell periphery   • protein localization to plasma membrane   • cellular macromolecule localization   • macromolecule localization   • localization within membrane   • protein localization to membrane   • system process   • nervous system process   • cognition   • regulation of cellular component organization   • cellular component organization   • regulation of synapse organization   • cell junction organization   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of biological quality   • postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction
Gene OntologyCellular Component• postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction   • postsynaptic membrane   • asymmetric synapse   • plasma membrane region   • presynapse   • presynaptic membrane   • cell projection   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • nucleus   • intracellular membrane-bounded organelle
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ5T848
Sequence
>7EWL_Chain_R
AQKLAEEVP MDVASYLYT GDSHQLKRA NCSGRYELA GLPGKWPAL 
ASAHPSLHR ALDTLTHAT NFLNVMLQS NKSREQNLQ DDLDWYQAL 
VWSLLEGEP SISRAAITF STQVFLQAT REESRILLQ DLSSSAPHL 
ANATLETHF KWSPPYLEC ENGSYKPGW LVTLSSAIY EFRGVMKVD 
INLQKVDID QCSSDGWFS GTHKCHLNN SECMPIKGL GFVLGAYEC 
ICKAGFYHY VCLPCREGC PFCADDSPC FVQEDKYLR LAIISFQAL 
CMLLDFVSM LVVYHFRKA KSIRASGLI LLETILFGS LLLYFPVVI 
LYFEPSTFR CILLRWARL LGFATVYGT VTLKLHRVL KVFLRVMRM 
LAVILLVVF WFLIGWTSS VCQNLEKQI SLIGQGKTS DHLIFNMCL 
IDRWDYMTA VAEFLFLLW GVYLCYAVR TVPSAFHEP RYMAVAVHN 
ELIISAIFH TIRFVLASR LQSDWMLML YFAHTHLTV TVTIGLLLI 
PKFS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ5T848
Sequence
>7EWL_Chain_S
QKLAEEVPM DVASYLYTG DSHQLKRAN CSGRYELAG LPGKWPALA 
SAHPSLHRA LDTLTHATN FLNVMLQSN KSREQNLQD DLDWYQALV 
WSLLEGEPS ISRAAITFS TQVFLQATR EESRILLQD PHLANATLE 
THFKWSPPY LECENGSYK PGWLVTLSS AIYEFRGVM KVDINLQKV 
DIDQCSSDG WFSGTHKCH LNNSECMPI KGLGFVLGA YECICKAGF 
YHPAYVCLP CREGCPFCA DDSPCFVQE DKYLRLAII SFQALCMLL 
DFVSMLVVY HFRKAKSIR ASGLILLET ILFGSLLLY FPVVILYFE 
PSTFRCILL RWARLLGFA TVYGTVTLK LHRVLKVFL RVMRMLAVI 
LLVVFWFLI GWTSSVCQN LEKQISLIG QGKTSDHLI FNMCLIDRW 
DYMTAVAEF LFLLWGVYL CYAVRTVPS AFHEPRYMA VAVHNELII 
SAIFHTIRF VLASRLQSD WMLMLYFAH THLTVTVTI GLLLIPKFS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SHECOrphanOrphanGPR158Homo sapiens-PI; PE-3.42021-12-0110.1126/science.abl4732
7EWLCOrphanOrphanGPR158Homo sapiens---3.522021-12-0110.1038/s41467-021-27147-1
7SHFCOrphanOrphanGPR158Homo sapiens-PI; PEB5; RGS73.42021-12-0110.1126/science.abl4732
7EWRCOrphanOrphanGPR158Homo sapiens--B5; RGS74.72021-12-0110.1038/s41467-021-27147-1
7EWPCOrphanOrphanGPR158Homo sapiens--B5; RGS74.32021-12-0110.1038/s41467-021-27147-1




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EWL.zip



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