Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y87 14.35254186
2R:R:S100 7.01497
3R:R:R102 9.365495
4R:R:P109 3.914174
5R:R:D153 3.93254119
6R:R:W156 16.4945119
7R:R:W162 5.844247
8R:R:E166 7.595408
9R:R:E168 4.477218
10R:R:R173 7.728517
11R:R:T177 8.965418
12R:R:S209 3.6825414
13R:R:A210 4.06415
14R:R:H212 13.365413
15R:R:Y269 7.14415
16R:R:Y277 7.90571798
17R:R:L282 6.7675417
18R:R:T284 8.446518
19R:R:I289 4.3125108
20R:R:F300 13.3185138
21R:R:M304 5.8054107
22R:R:K305 10.038518
23R:R:V306 5.3825407
24R:R:D307 4.602519
25R:R:I308 4.795206
26R:R:N309 4.1925417
27R:R:L310 5.784208
28R:R:Q317 5.824559
29R:R:C318 5.085459
30R:R:G322 2.29254195
31R:R:F324 5.8275459
32R:R:N334 2.67407
33R:R:L347 5.6825459
34R:R:Y350 5.88143759
35R:R:R417 5.296676279
36R:R:F423 5.84465
37R:R:S450 4.8085129
38R:R:Y466 4.836568
39R:R:W486 7.375409
40R:R:R488 6.094539
41R:R:F492 11.026539
42R:R:Y496 9.235439
43R:R:G497 2.0754299
44R:R:K502 4.70254129
45R:R:L503 2.98508
46R:R:W544 7.3875409
47R:R:I559 2.0225408
48R:R:K563 4.1185314
49R:R:I575 4.112536
50R:R:R577 6.006508
51R:R:W578 7.308509
52R:R:M581 3.02254329
53R:R:V600 2.74754309
54R:R:V603 4.52254309
55R:R:E609 6.20754129
56R:R:E620 6.50167639
57R:R:F627 14.415409
58R:R:H628 6.39333638
59R:R:F632 6.676539
60R:R:L634 3.56405
61R:R:Y647 8.58405
62R:R:F648 6.195469
63R:R:H652 7.59569
64R:R:T654 4.78409
65R:R:V655 3.95833667
66R:R:I659 3.1125467
67R:R:L663 2.45408
68S:S:Y87 12.56446
69S:S:R96 11.038543
70S:S:C99 2.2525449
71S:S:F135 6.7375408
72S:S:M139 6.97407
73S:S:E147 5.694119
74S:S:D153 5.89754119
75S:S:W156 17.9845119
76S:S:Y157 3.831676119
77S:S:F178 7.805406
78S:S:T180 4.3575404
79S:S:I201 5.865239
80S:S:L213 7.27754356
81S:S:K264 6.784354
82S:S:W265 9.84407
83S:S:Y269 7.215445
84S:S:Y277 5.314548
85S:S:K278 11.075445
86S:S:P279 4.515449
87S:S:W281 15.5754339
88S:S:L282 12.1175447
89S:S:F300 2.9425408
90S:S:M304 5.5625347
91S:S:I308 5.0845146
92S:S:Q311 5.68254339
93S:S:Q317 2.7975409
94S:S:W323 2.365409
95S:S:F324 3.028509
96S:S:P339 4.7325478
97S:S:L343 1.585404
98S:S:F345 8.05254339
99S:S:V346 3.2775407
100S:S:Y350 4.19333679
101S:S:C395 2.65754369
102S:S:R417 6.2425159
103S:S:F423 4.575485
104S:S:D431 4.365406
105S:S:S450 6.344169
106S:S:E456 3.2825409
107S:S:Y466 4.20333688
108S:S:Y473 5.805408
109S:S:I482 2.9075407
110S:S:W486 8.765409
111S:S:R488 5.2529
112S:S:F492 10.68529
113S:S:Y496 10.982529
114S:S:F540 3.5125429
115S:S:G543 2.844328
116S:S:W544 6.775629
117S:S:K563 4.19404
118S:S:R577 5.395408
119S:S:W578 7.64167629
120S:S:M581 4.205409
121S:S:E586 9.005429
122S:S:L590 3.49429
123S:S:L596 2.48409
124S:S:E609 6.254169
125S:S:E620 8.16529
126S:S:F627 8.88529
127S:S:H628 5.09628
128S:S:F632 7.9575429
129S:S:Y647 6.084525
130S:S:H652 7.442589
131S:S:T654 5.48409
132S:S:V655 3.95833687
133S:S:I659 3.1125487
134S:S:L663 2.6825408
135S:S:K666 6.5554169
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I308 R:R:V306 16.24354.61YesYes067
2R:R:I171 R:R:V306 16.410.75NoYes087
3R:R:I171 R:R:L165 17.52474.28NoNo086
4R:R:I201 R:R:L165 17.59337.14NoNo096
5R:R:I201 R:R:W162 17.661416.44NoYes097
6R:R:W162 S:S:V138 17.92932.45YesNo076
7R:R:E166 S:S:V138 17.995211.41YesNo086
8R:R:E166 R:R:S163 18.19012.87YesNo088
9R:R:S163 S:S:F135 18.25425.28NoYes088
10R:R:M139 S:S:W156 17.456923.27NoYes079
11R:R:M139 S:S:A159 17.39173.22NoNo079
12R:R:V138 S:S:A159 17.3261.7NoNo069
13R:R:V138 S:S:W162 17.19343.68NoNo067
14S:S:I201 S:S:W162 17.02267.05YesNo2397
15S:S:I201 S:S:L165 16.71528.56YesNo096
16S:S:A174 S:S:L165 16.64514.73NoNo096
17S:S:A174 S:S:L164 16.57463.15NoNo095
18S:S:L164 S:S:V306 16.43224.47NoNo057
19S:S:I171 S:S:V306 16.2887.68NoNo087
20R:R:W156 S:S:W156 10.113251.54YesYes1199
21S:S:A125 S:S:I171 15.91993.25NoNo078
22S:S:A125 S:S:I308 15.30774.87NoYes076
23R:R:R417 R:R:Y473 24.701610.29YesNo098
24R:R:L644 R:R:R417 38.15284.86NoYes099
25R:R:I420 R:R:L644 40.39312.85NoNo089
26R:R:F648 R:R:I420 42.632910.05YesNo098
27R:R:I421 R:R:Y473 20.214410.88NoNo078
28R:R:I421 R:R:V470 17.97013.07NoNo077
29R:R:F423 R:R:F648 15.70524.29YesYes659
30R:R:C427 R:R:F423 17.19074.19NoYes685
31R:R:C427 R:R:H652 17.19125.9NoYes689
32R:R:F648 R:R:H652 31.40599.05YesYes699
33R:R:H652 R:R:Q424 17.19723.71YesNo099
34R:R:C427 R:R:Y466 35.11912.69NoYes688
35R:R:Q424 R:R:Y466 18.68056.76NoYes098
36R:R:V655 R:R:Y466 56.70355.05YesYes678
37R:R:I659 R:R:V655 12.10423.07YesYes677
38R:R:S462 R:R:V655 10.59113.23NoYes697
39R:R:T654 R:R:V655 80.55124.76YesYes097
40R:R:E620 R:R:T654 43.25267.06YesYes099
41R:R:L541 R:R:W486 11.926517.08NoYes099
42R:R:L541 R:R:V537 11.64772.98NoNo099
43R:R:A493 R:R:V537 11.4351.7NoNo089
44R:R:A493 R:R:I533 11.00831.62NoNo088
45R:R:G497 R:R:I533 10.34491.76YesNo2998
46R:R:I471 R:R:V470 15.72541.54NoNo097
47R:R:H650 R:R:T654 41.72222.74NoYes099
48R:R:F627 R:R:H650 21.426529.41YesNo099
49R:R:W578 S:S:W578 1008.43YesYes099
50R:R:W544 R:R:W578 55.59638.43YesYes099
51R:R:R485 R:R:W544 44.963713.99NoYes099
52R:R:D579 R:R:R485 44.963511.91NoNo099
53R:R:D579 R:R:F632 44.20762.39NoYes399
54R:R:F632 R:R:H628 90.81866.79YesYes398
55R:R:H628 R:R:R488 44.24696.77YesYes389
56R:R:E620 R:R:R488 22.04612.33YesYes399
57R:R:D576 R:R:W578 44.79255.58NoYes089
58R:R:D576 R:R:R577 45.43742.38NoYes088
59R:R:R577 R:R:Y580 48.09184.12YesNo088
60R:R:F632 R:R:Y580 47.459112.38YesNo398
61R:R:H628 R:R:S624 22.12648.37YesNo089
62R:R:E620 R:R:S624 21.95034.31YesNo099
63R:R:H650 R:R:R488 20.95782.26NoYes099
64R:R:F627 R:R:H628 23.27315.66YesYes098
65S:S:F540 S:S:W578 69.56914.01YesYes299
66S:S:F540 S:S:L489 52.54562.44YesNo297
67S:S:L489 S:S:R488 52.31872.43NoYes279
68S:S:H650 S:S:R488 36.86556.77NoYes099
69S:S:H650 S:S:T654 33.65716.85NoYes099
70S:S:T654 S:S:V655 32.98444.76YesYes097
71S:S:V655 S:S:Y466 22.15395.05YesYes878
72S:S:Q424 S:S:Y466 10.41047.89NoYes098
73S:S:F492 S:S:R488 11.70085.34YesYes299
74S:S:F492 S:S:Y496 18.522317.54YesYes299
75S:S:V495 S:S:Y496 17.78568.83NoYes089
76S:S:I458 S:S:V495 17.15634.61NoNo098
77S:S:I458 S:S:T498 13.37173.04NoNo099
78S:S:L454 S:S:T498 12.73945.9NoNo099
79S:S:K502 S:S:L454 10.83985.64NoNo099
80S:S:F540 S:S:T582 16.40892.59YesNo298
81S:S:E586 S:S:T582 16.17914.23YesNo298
82S:S:E586 S:S:F492 11.623619.82YesYes299
83S:S:W544 S:S:W578 29.45669.37YesYes299
84S:S:I482 S:S:W544 16.22594.7YesYes079
85S:S:I482 S:S:W486 13.06992.35YesYes079
86S:S:T545 S:S:W544 13.30563.64NoYes099
87S:S:T545 S:S:W486 12.996.06NoYes099
88S:S:F627 S:S:H628 12.71832.26YesYes298
89S:S:F627 S:S:Y647 10.66710.32YesYes295
90S:S:L541 S:S:W486 18.96121.64NoYes099
91S:S:L541 S:S:V537 18.31342.98NoNo099
92S:S:A493 S:S:V537 17.66531.7NoNo089
93S:S:A493 S:S:I533 17.01681.62NoNo088
94S:S:F589 S:S:I533 16.36792.51NoNo088
95S:S:F589 S:S:W592 13.11643.01NoNo089
96S:S:T500 S:S:W592 12.46484.85NoNo079
97S:S:G593 S:S:T500 11.81283.64NoNo077
98S:S:G593 S:S:L596 11.16021.71NoYes079
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EWL
Class C
SubFamily Orphan
Type C orphans
SubType GPR158
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.52
Date 2021-12-01
D.O.I. 10.1038/s41467-021-27147-1
Net Summary
Imin 1.7
Number of Linked Nodes 909
Number of Links 1021
Number of Hubs 135
Number of Links mediated by Hubs 493
Number of Communities 37
Number of Nodes involved in Communities 207
Number of Links involved in Communities 264
Path Summary
Number Of Nodes in MetaPath 99
Number Of Links MetaPath 98
Number of Shortest Paths 698139
Length Of Smallest Path 3
Average Path Length 24.1361
Length of Longest Path 59
Minimum Path Strength 1.195
Average Path Strength 6.04927
Maximum Path Strength 37.405
Minimum Path Correlation 0.7
Average Path Correlation 0.986609
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 61.8602
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.1315
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ5T848
Sequence
>7EWL_Chain_R
AQKLAEEVP MDVASYLYT GDSHQLKRA NCSGRYELA GLPGKWPAL 
ASAHPSLHR ALDTLTHAT NFLNVMLQS NKSREQNLQ DDLDWYQAL 
VWSLLEGEP SISRAAITF STQVFLQAT REESRILLQ DLSSSAPHL 
ANATLETHF KWSPPYLEC ENGSYKPGW LVTLSSAIY EFRGVMKVD 
INLQKVDID QCSSDGWFS GTHKCHLNN SECMPIKGL GFVLGAYEC 
ICKAGFYHY VCLPCREGC PFCADDSPC FVQEDKYLR LAIISFQAL 
CMLLDFVSM LVVYHFRKA KSIRASGLI LLETILFGS LLLYFPVVI 
LYFEPSTFR CILLRWARL LGFATVYGT VTLKLHRVL KVFLRVMRM 
LAVILLVVF WFLIGWTSS VCQNLEKQI SLIGQGKTS DHLIFNMCL 
IDRWDYMTA VAEFLFLLW GVYLCYAVR TVPSAFHEP RYMAVAVHN 
ELIISAIFH TIRFVLASR LQSDWMLML YFAHTHLTV TVTIGLLLI 
PKFS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ5T848
Sequence
>7EWL_Chain_S
AQKLAEEVP MDVASYLYT GDSHQLKRA NCSGRYELA GLPGKWPAL 
ASAHPSLHR ALDTLTHAT NFLNVMLQS NKSREQNLQ DDLDWYQAL 
VWSLLEGEP SISRAAITF STQVFLQAT REESRILLQ DLSSSAPHL 
ANATLETHF KWSPPYLEC ENGSYKPGW LVTLSSAIY EFRGVMKVD 
INLQKVDID QCSSDGWFS GTHKCHLNN SECMPIKGL GFVLGAYEC 
ICKAGFYHY VCLPCREGC PFCADDSPC FVQEDKYLR LAIISFQAL 
CMLLDFVSM LVVYHFRKA KSIRASGLI LLETILFGS LLLYFPVVI 
LYFEPSTFR CILLRWARL LGFATVYGT VTLKLHRVL KVFLRVMRM 
LAVILLVVF WFLIGWTSS VCQNLEKQI SLIGQGKTS DHLIFNMCL 
IDRWDYMTA VAEFLFLLW GVYLCYAVR TVPSAFHEP RYMAVAVHN 
ELIISAIFH TIRFVLASR LQSDWMLML YFAHTHLTV TVTIGLLLI 
PKFSPA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EWLCOrphanC orphansGPR158Homo sapiens---3.522021-12-0110.1038/s41467-021-27147-1
7EWPCOrphanC orphansGPR158Homo sapiens--B5; RGS74.32021-12-0110.1038/s41467-021-27147-1
7EWRCOrphanC orphansGPR158Homo sapiens--B5; RGS74.72021-12-0110.1038/s41467-021-27147-1
7SHECOrphanC orphansGPR158Homo sapiens-PI; PE-3.42021-12-0110.1126/science.abl4732
7SHFCOrphanC orphansGPR158Homo sapiens-PI; PEB5; RGS73.42021-12-0110.1126/science.abl4732




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EWL.zip



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