Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:L64 7.758598
2B:B:K65 7.298596
3B:B:L68 6.912597
4B:B:E69 4.9925494
5B:B:E71 5.6425494
6B:B:E79 7.563336244
7B:B:L80 4.2754245
8B:B:L90 6.4054254
9B:B:F93 5.194503
10B:B:H104 6.368509
11B:B:W113 6.7025478
12B:B:W132 11.3865639
13B:B:D133 7.9675478
14B:B:F135 5.486574
15B:B:M145 6.41254648
16B:B:W149 15.978539
17B:B:V150 5.99754649
18B:B:Y155 5.813336437
19B:B:C171 2.5454228
20B:B:K180 8.7145533
21B:B:N183 5.01754534
22B:B:K188 9.65754654
23B:B:Y197 6.928538
24B:B:S202 4.555436
25B:B:T204 4.455435
26B:B:S206 4.79254665
27B:B:D207 5.92408
28B:B:Q209 9.39405
29B:B:T212 6.0054229
30B:B:S214 5.6525439
31B:B:G215 4.54438
32B:B:D216 10.355439
33B:B:T218 8.9175437
34B:B:W222 9.41254229
35B:B:S226 5.6425406
36B:B:H236 7.234539
37B:B:S256 3.575439
38B:B:M264 6.4575407
39B:B:W266 11.676539
40B:B:T279 5.9954446
41B:B:D283 9.00754299
42B:B:R288 6.844574
43B:B:Y289 4.4545676
44B:B:Y290 5.0285696
45B:B:D302 7.4154549
46B:B:R306 7.218336448
47B:B:D309 4.8125409
48B:B:R314 9.65254247
49B:B:E315 9.564447
50B:B:Y319 3.5075406
51B:B:I324 5.576676134
52B:B:F326 4.215406
53B:B:R338 6.27259
54B:B:L339 5.6725175
55B:B:F341 7.4245176
56B:B:Y344 9.6245138
57B:B:N345 7.4985297
58B:B:D346 5.6254138
59B:B:Y347 6.79254134
60B:B:T348 5.74254135
61B:B:N350 9.191676136
62B:B:W352 5.1185139
63B:B:L355 4.1325257
64B:B:K356 2.8825406
65B:B:R359 11.28254136
66B:B:I362 9.2345134
67B:B:F364 6.87254134
68B:B:R374 6.32475
69B:B:P377 4.795472
70B:B:D378 8.66167678
71B:B:F382 9.90254175
72B:B:W387 14.9975408
73B:B:D388 7.794709
74B:B:W394 6.575178
75E:E:P19 4.124290
76E:E:M27 8.0254450
77E:E:M34 5.7275400
78E:E:I41 5.688540
79E:E:P54 4.755400
80E:E:F57 6.872540
81E:E:W65 7.526500
82E:E:E77 6.7725130
83E:E:M85 3.6585450
84E:E:H88 6.234450
85E:E:Y90 10.04754450
86E:E:F92 5.85400
87E:E:H97 6.395150
88E:E:V98 3.185400
89E:E:Y108 6.3775400
90E:E:R109 6.688540
91E:E:F110 8.72440
92E:E:Q111 4.122540
93E:E:T112 5.49375840
94E:E:Y114 7.948540
95E:E:F115 11.38640
96E:E:Y128 5.6085150
97E:E:M137 3.724750
98E:E:Q138 10.19754760
99E:E:R142 3.675400
100E:E:Y148 9.3645150
101E:E:E149 10.0945150
102E:E:F166 12.92336110
103E:E:M169 9.49754110
104E:E:E172 4.04254750
105E:E:R181 11.395440
106E:E:R186 11.51254760
107E:E:Q192 5.42667640
108E:E:R194 8.55754150
109E:E:F196 13.4075440
110E:E:W197 5.398500
111E:E:K215 5.238530
112E:E:Q261 6.83590
113E:E:W265 9.896590
114E:E:Q268 6.51590
115E:E:R273 8.932590
116E:E:M276 6.974240
117E:E:L291 6.35254250
118E:E:D294 7.6175400
119E:E:F296 4.41754170
120E:E:L297 5.88754250
121E:E:W306 4.89667670
122E:E:F313 5.78470
123E:E:W314 9.4525470
124E:E:P322 5.3265300
125E:E:R326 7.135300
126E:E:W330 7.0345300
127E:E:F332 6.6125400
128E:E:M334 10.36400
129E:E:D340 9.3445300
130E:E:V342 6.41254300
131E:E:W363 9.2954320
132E:E:R380 8.125450
133E:E:V381 4.594550
134E:E:Q382 3.58450
135E:E:I384 5.9450
136E:E:W385 9.88143750
137E:E:E387 9.44450
138E:E:L389 8.32333650
139E:E:I397 6.3075450
140E:E:L399 6.282550
141E:E:Y404 6.56167650
142E:E:K406 9.29400
143E:E:T407 5.305650
144E:E:P414 6.184550
145E:E:T418 6.9725450
146E:E:F419 8.0175450
147E:E:I426 7.6054320
148E:E:M430 6.0654320
149E:E:Y435 8.8385310
150E:E:Y444 7.70754310
151T:T:P19 4.124338
152T:T:Y24 2.90754464
153T:T:M27 8.0254468
154T:T:M34 5.7275408
155T:T:I41 5.9825558
156T:T:P54 4.755408
157T:T:F57 6.6665555
158T:T:W65 7.526506
159T:T:E77 6.7725149
160T:T:L84 4.954149
161T:T:M85 3.6585466
162T:T:Y90 10.04754469
163T:T:F92 5.85409
164T:T:H97 6.395239
165T:T:V98 3.185407
166T:T:Y108 6.12408
167T:T:R109 4.6125409
168T:T:Q111 4.1225349
169T:T:T112 4.0285348
170T:T:Y114 7.44254347
171T:T:F115 12.9565347
172T:T:Y128 4.67508
173T:T:R135 3.72409
174T:T:M137 3.394829
175T:T:Y148 9.3645238
176T:T:E149 10.0945239
177T:T:F160 4.314818
178T:T:W164 6.7275409
179T:T:E172 4.04254829
180T:T:R181 12.38754568
181T:T:R186 10.9175409
182T:T:R194 8.55754239
183T:T:F196 13.40754349
184T:T:W197 5.398509
185T:T:K215 5.2385129
186T:T:L291 6.35254261
187T:T:D294 7.6175409
188T:T:F296 4.41754184
189T:T:L297 5.2645264
190T:T:W306 4.89667688
191T:T:F313 5.78483
192T:T:W314 9.4525487
193T:T:R326 7.9445479
194T:T:W330 7.784479
195T:T:F332 6.6125408
196T:T:M334 10.36405
197T:T:D340 9.3445479
198T:T:V342 6.2254474
199T:T:W363 9.2954376
200T:T:P373 4.864577
201T:T:R380 8.125466
202T:T:V381 4.594568
203T:T:Q382 3.58464
204T:T:I384 5.9469
205T:T:W385 9.88143766
206T:T:E387 9.44469
207T:T:L389 8.32333669
208T:T:I397 6.3075468
209T:T:L399 6.282567
210T:T:Y404 6.56167664
211T:T:K406 9.29403
212T:T:T407 5.305669
213T:T:P414 6.184566
214T:T:T418 6.9725465
215T:T:F419 8.0175465
216T:T:I426 7.6054378
217T:T:M430 6.0654379
218T:T:Y435 8.8385369
219T:T:Y444 7.70754369
220F:F:V78 3.82404
221F:F:E79 7.6425354
222F:F:L80 4.2754355
223F:F:L90 6.4054264
224F:F:F93 5.194503
225F:F:H104 6.368509
226F:F:W113 6.7025488
227F:F:D126 6.8925409
228F:F:W132 11.3865859
229F:F:D133 7.9675488
230F:F:F135 5.486584
231F:F:M145 6.41254868
232F:F:W149 15.9785129
233F:F:V150 5.99754869
234F:F:Y155 5.813336487
235F:F:K180 8.7145583
236F:F:N183 5.01754584
237F:F:K188 9.65754874
238F:F:Y197 6.9285128
239F:F:D207 4.655888
240F:F:M208 4.06754573
241F:F:T212 6.0054389
242F:F:S214 5.65254129
243F:F:G215 4.544128
244F:F:D216 10.3554129
245F:F:T218 8.91754127
246F:F:W222 9.41254389
247F:F:S226 5.6425406
248F:F:F233 12.3454497
249F:F:H236 9.2925409
250F:F:G257 1.9454197
251F:F:M264 6.4575407
252F:F:W266 12.175499
253F:F:D283 9.00754339
254F:F:I284 5.74254198
255F:F:R288 6.844584
256F:F:Y289 4.706506
257F:F:Y290 5.0285846
258F:F:R306 8.377147198
259F:F:D309 4.8125409
260F:F:E315 9.20754197
261F:F:Y319 3.5075406
262F:F:I324 5.576676144
263F:F:R338 6.27269
264F:F:L339 5.6725185
265F:F:F341 7.4245186
266F:F:Y344 9.6245148
267F:F:N345 8.015337
268F:F:D346 6.22254148
269F:F:Y347 6.79254144
270F:F:T348 5.74254145
271F:F:N350 9.191676146
272F:F:W352 5.1185149
273F:F:L355 4.1325267
274F:F:K356 2.8825406
275F:F:R359 11.28254146
276F:F:I362 9.2345144
277F:F:F364 6.87254144
278F:F:R374 6.32485
279F:F:P377 4.795482
280F:F:D378 8.66167688
281F:F:F382 9.90254185
282F:F:W387 14.9975408
283F:F:D388 7.794899
284F:F:W394 6.575188
285R:R:Q72 11.13414
286R:R:L86 5.19418
287R:R:Y87 3.59667616
288R:R:S91 6.04414
289R:R:L94 7.75167619
290R:R:K95 9.94412
291R:R:N98 7.56418
292R:R:F135 5.59408
293R:R:M139 3.65407
294R:R:Q148 11.712526
295R:R:N149 3.9075407
296R:R:D152 6.0075426
297R:R:D153 9.522529
298R:R:W156 14.94629
299R:R:Y157 6.036529
300R:R:W162 10.9654507
301R:R:L165 6.2485506
302R:R:I176 6.005427
303R:R:F178 7.722526
304R:R:T180 5.856524
305R:R:F191 7.9345398
306R:R:P267 5.275405
307R:R:Y269 8.10167615
308R:R:E271 9.695418
309R:R:S276 5.19414
310R:R:Y277 13.995418
311R:R:K278 9.9725415
312R:R:W281 27.115419
313R:R:V283 4.92416
314R:R:T284 4.8125418
315R:R:I289 5.272528
316R:R:K305 4.4065398
317R:R:I308 5.6375416
318R:R:N309 4.275407
319R:R:L310 5.3125418
320R:R:I315 4.39418
321R:R:Q317 5.6275409
322R:R:C318 6.09254519
323R:R:W323 15.4125419
324R:R:H328 5.474909
325R:R:N334 5.9654927
326R:R:C337 5.01754519
327R:R:P339 5.194518
328R:R:F345 8.7125419
329R:R:L347 5.37419
330R:R:Y350 4.9345519
331R:R:Y359 5.6025409
332R:R:C392 5.17254929
333R:R:F409 4.6625593
334R:R:E412 11.46754527
335R:R:R417 6.766529
336R:R:Q424 10.6354219
337R:R:M428 4.53754217
338R:R:S446 3.665408
339R:R:Y466 9.5265218
340R:R:F467 2.88254217
341R:R:R485 8.4375409
342R:R:R488 4.645409
343R:R:Y496 8.7845409
344R:R:K502 3.585409
345R:R:F510 4.7654779
346R:R:W544 8.1675409
347R:R:N551 3.36407
348R:R:Q561 2.985405
349R:R:W578 6.642509
350R:R:E586 8.765409
351R:R:L590 2.20254409
352R:R:P604 3.4085779
353R:R:E620 8.0625409
354R:R:I623 5.3325405
355R:R:F627 8.165409
356R:R:H628 6.6025408
357R:R:Q639 8.65754529
358R:R:Y647 7.2975405
359R:R:H650 6.3685409
360R:R:H652 9.066219
361R:R:W704 7.64947
362R:R:E706 5.79448
363R:R:L709 8.118549
364R:R:D713 7.255449
365R:R:D716 4.9625447
366R:R:E717 9.2425449
367R:R:L721 7.415119
368R:R:Y722 7.714119
369R:R:Q724 7.65754119
370R:R:K731 6.54254119
371R:R:T735 3.08407
372R:R:K743 4.0054119
373R:R:K747 3.1945119
374R:R:L750 5.864118
375R:R:I754 4.03754117
376R:R:R756 8.545567
377S:S:Y85 12.86176108
378S:S:D90 6.054607
379S:S:Q93 7.7925104
380S:S:L105 11.51754105
381S:S:L129 4.0054416
382S:S:M139 6.935407
383S:S:D152 8.668526
384S:S:D153 6.046529
385S:S:W156 12.7771729
386S:S:Y157 7.598529
387S:S:W162 7.848336277
388S:S:I171 9.4075408
389S:S:T177 6.6885168
390S:S:F178 7.8175426
391S:S:F191 14.5854168
392S:S:L192 4.266529
393S:S:I201 8.47754279
394S:S:L203 6.0485279
395S:S:S209 3.4754164
396S:S:P211 6.414164
397S:S:K264 8.72754164
398S:S:L270 11.394109
399S:S:C272 3.9045109
400S:S:Y277 10.9358108
401S:S:W281 15.7025109
402S:S:I289 5.554978
403S:S:Y290 6.77408
404S:S:R301 8.94508
405S:S:V303 3.485169
406S:S:K305 8.916168
407S:S:D307 5.08754169
408S:S:L310 10.08254108
409S:S:Q311 11.06754109
410S:S:C318 5.664209
411S:S:W323 6.8265969
412S:S:C337 3.9756209
413S:S:F345 8.064109
414S:S:Y350 7.815209
415S:S:I420 3.86408
416S:S:E456 3.922541009
417S:S:I458 3.0375409
418S:S:G461 1.874629
419S:S:L464 2.8054628
420S:S:Y466 7.828577288
421S:S:Y496 5.7965429
422S:S:T498 3.805409
423S:S:T500 3.0975407
424S:S:W544 7.0225409
425S:S:I559 3.545408
426S:S:K563 3.0925404
427S:S:I569 2.7475405
428S:S:F570 3.875999
429S:S:W578 6.6275409
430S:S:E586 8.26754429
431S:S:L590 3.0054429
432S:S:V603 4.7775409
433S:S:E609 3.04851019
434S:S:E620 8.21754429
435S:S:F627 17.2475409
436S:S:H628 7.554428
437S:S:M643 3.795408
438S:S:Y647 7.99405
439S:S:F648 6.78254289
440S:S:H652 9.436676289
441S:S:T654 4.7875409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:E69 B:B:R72 17.87444.65YesNo046
2B:B:R314 B:B:R72 18.35758.53YesNo076
3B:B:E79 B:B:L80 10.38623.98YesYes2445
4B:B:A84 B:B:L80 21.49431.58NoYes055
5B:B:A84 B:B:L355 21.73561.58NoYes057
6B:B:L355 B:B:R338 1006.07YesYes2579
7B:B:R338 E:E:L297 1003.64YesYes2590
8B:B:F93 E:E:L297 1004.87YesYes030
9B:B:F93 B:B:M95 10012.44YesNo035
10B:B:A395 B:B:M95 1004.83NoNo085
11B:B:A395 E:E:F296 1002.77NoYes080
12E:E:D294 E:E:F296 1005.97YesYes000
13E:E:D294 E:E:L297 1009.5YesYes000
14B:B:S336 E:E:D294 10011.78NoYes090
15B:B:R338 B:B:S336 1003.95YesNo099
16B:B:A395 B:B:R98 1005.53NoNo087
17B:B:R98 E:E:L307 1009.72NoNo070
18B:B:F135 B:B:R99 25.97054.28YesNo747
19B:B:R99 E:E:W306 26.61295NoYes770
20E:E:N304 E:E:W306 1004.52NoYes000
21E:E:L307 E:E:N304 1006.87NoNo000
22B:B:I120 B:B:S134 16.16463.1NoNo056
23B:B:S134 E:E:W306 16.80734.94NoYes760
24E:E:N304 E:E:P305 1003.26NoNo000
25E:E:F313 E:E:P305 1004.33YesNo700
26E:E:D301 E:E:F313 1007.17NoYes000
27E:E:D301 E:E:Q325 1005.22NoNo000
28E:E:Q325 E:E:S323 1008.66NoNo000
29E:E:R326 E:E:S323 1002.64YesNo000
30E:E:D340 E:E:R326 1008.34YesYes3000
31E:E:D340 E:E:P341 1008.05YesNo000
32E:E:P341 E:E:R344 1002.88NoNo000
33E:E:L338 E:E:R344 1006.07NoNo000
34E:E:L338 E:E:W363 1003.42NoYes000
35E:E:Q423 E:E:W363 10010.95NoYes000
36E:E:K370 E:E:Q423 1005.42NoNo000
37E:E:K370 E:E:R416 1002.48NoNo000
38B:B:Q209 E:E:R416 10015.19YesNo050
39B:B:Q209 B:B:T204 1002.83YesYes055
40B:B:L211 B:B:T204 1002.95NoYes365
41B:B:F254 B:B:L211 10015.83NoNo386
42B:B:F254 B:B:W266 10011.02NoYes389
43B:B:S256 B:B:W266 1004.94YesYes399
44B:B:S256 B:B:V240 1004.85YesNo399
45B:B:G217 B:B:V240 1001.84NoNo379
46B:B:D216 B:B:G217 1005.03YesNo397
47B:B:D216 B:B:S214 1007.36YesYes399
48B:B:N196 B:B:S214 1005.96NoYes389
49B:B:N196 B:B:Y197 10011.63NoYes388
50B:B:Y197 E:E:K215 1003.58YesYes380
51E:E:D213 E:E:K215 1006.91NoYes300
52B:B:W149 E:E:D213 10011.17YesNo390
53B:B:Q125 B:B:W149 10024.09NoYes099
54B:B:N106 B:B:Q125 1005.28NoNo069
55E:E:P305 E:E:W314 10027.02NoYes700
56B:B:D378 E:E:W314 1003.35YesYes780
57B:B:D378 B:B:K117 10013.83YesNo085
58B:B:K117 E:E:E317 1004.05NoNo050
59E:E:E317 E:E:R326 10015.12NoYes000
60B:B:T380 E:E:W306 1007.28NoYes750
61B:B:D378 B:B:T380 10013.01YesNo785
62B:B:G215 B:B:S214 1003.71YesYes389
63B:B:G215 B:B:Y197 1004.35YesYes388
64B:B:D126 B:B:N106 1005.39NoNo096
65B:B:W352 B:B:Y319 1007.72YesYes096
66B:B:V354 B:B:Y319 1002.52NoYes056
67B:B:L355 B:B:V354 1005.96YesNo075
68B:B:D116 B:B:R118 13.63514.76NoNo086
69B:B:F135 B:B:R118 14.284210.69YesNo746
70B:B:R119 B:B:Y155 11.68755.14NoYes067
71B:B:D126 B:B:G127 1003.35NoNo099
72B:B:G127 B:B:V150 1001.84NoYes099
73B:B:S123 B:B:V150 23.28768.08NoYes099
74B:B:S123 B:B:V129 19.40626.46NoNo097
75B:B:C164 B:B:V150 23.28743.42NoYes6479
76B:B:C164 B:B:V129 19.40693.42NoNo077
77B:B:V129 B:B:V143 31.05054.81NoNo077
78B:B:H141 B:B:M184 15.52537.88NoNo053
79B:B:M184 B:B:V143 23.28796.09NoNo037
80B:B:M145 B:B:V150 97.03110.65YesYes6489
81B:B:M145 B:B:P146 85.38855.03YesNo085
82B:B:K188 B:B:P146 73.74483.35YesNo045
83B:B:D207 B:B:F203 11.65044.78YesNo089
84B:B:F203 B:B:I210 15.53378.79NoNo096
85B:B:I210 B:B:T212 23.30033.04NoYes069
86B:B:T212 B:B:W222 34.94987.28YesYes2299
87B:B:L229 B:B:W222 38.832814.81NoYes2259
88B:B:L229 B:B:S232 42.71593NoNo055
89B:B:H234 B:B:S232 44.65744.18NoNo035
90B:B:H234 B:B:T218 46.598919.17NoYes037
91B:B:G217 B:B:T218 50.4463.64NoYes377
92B:B:K188 B:B:Y174 58.219914.33YesNo6546
93B:B:A185 B:B:Y174 54.33884NoNo036
94B:B:D179 B:B:K180 23.28822.77NoYes033
95B:B:K180 B:B:N183 38.81352.8YesYes5334
96B:B:A185 B:B:N183 50.45754.69NoYes034
97B:B:K180 B:B:K187 11.644117.24YesNo035
98B:B:D179 B:B:T177 11.64427.23NoNo034
99B:B:Q209 B:B:S206 29.114311.55YesYes055
100B:B:S206 E:E:K371 21.35153.06YesNo6650
101E:E:R416 E:E:Y417 15.517611.32NoNo000
102E:E:P373 E:E:R372 17.4712.88NoNo000
103E:E:K371 E:E:R372 19.41133.71NoNo000
104E:E:Q423 E:E:V366 10014.33NoNo000
105E:E:F362 E:E:V366 1007.87NoNo000
106E:E:F362 E:E:I397 1007.54NoYes000
107E:E:I397 E:E:L389 1008.56YesYes500
108E:E:F419 E:E:L389 93.09822.44YesYes500
109E:E:F419 E:E:V381 34.90883.93YesYes500
110E:E:P414 E:E:V381 27.15377.07YesYes500
111E:E:P414 E:E:V377 11.64243.53YesNo500
112E:E:M430 E:E:W363 1009.31YesYes3200
113E:E:I426 E:E:M430 1005.83YesYes3200
114E:E:F362 E:E:I426 1007.54NoYes000
115B:B:R269 E:E:Y417 11.640616.46NoNo090
116B:B:C273 B:B:W266 52.37729.14NoYes069
117B:B:C273 B:B:M264 50.43754.86NoYes067
118B:B:K262 B:B:M264 46.57894.32NoYes057
119B:B:E278 B:B:K262 44.65926.75NoNo035
120B:B:E278 B:B:K261 42.71766.75NoNo034
121B:B:K261 B:B:T279 40.7763NoYes046
122B:B:R306 B:B:T279 31.067610.35YesYes4486
123B:B:E281 B:B:R306 11.65053.49NoYes048
124B:B:R306 B:B:T304 13.59223.88YesNo086
125B:B:N350 B:B:W352 1004.52YesYes1369
126B:B:N350 B:B:R359 10010.85YesYes1366
127E:E:H88 E:E:M27 10.29692.63YesYes4500
128B:B:I362 B:B:N350 1007.08YesYes1346
129B:B:R359 E:E:E77 10012.79YesYes1360
130B:B:I362 E:E:E77 1008.2YesYes1340
131E:E:E77 E:E:I72 1005.47YesNo000
132E:E:I72 E:E:L70 1002.85NoNo000
133E:E:L70 E:E:W65 1002.28NoYes000
134E:E:I62 E:E:M34 10.68755.83NoYes000
135E:E:I41 E:E:W65 1007.05YesYes000
136E:E:F110 E:E:I41 1005.02YesYes400
137E:E:F110 R:R:W704 10015.03YesYes407
138E:E:F57 E:E:I41 34.53718.79YesYes400
139E:E:F57 E:E:Y108 35.016411.35YesYes000
140E:E:T112 R:R:W704 1004.85YesYes407
141E:E:Q111 E:E:T112 35.81292.83YesYes400
142E:E:Q192 R:R:W704 36.33334.38YesYes407
143E:E:Q111 E:E:Q192 35.98022.56YesYes400
144E:E:P93 E:E:Y108 34.58182.78NoYes000
145E:E:D96 E:E:P93 34.00623.22NoNo000
146E:E:D96 E:E:V98 33.86242.92NoYes000
147E:E:V203 E:E:V98 33.68934.81NoYes000
148E:E:V203 E:E:Y148 33.56946.31NoYes1500
149E:E:E149 E:E:Y148 33.541323.57YesYes1500
150E:E:F196 E:E:Q111 71.6033.51YesYes400
151E:E:F196 E:E:W197 1008.02YesYes000
152E:E:W197 E:E:Y128 1008.68YesYes000
153E:E:E149 E:E:Y128 1003.37YesYes1500
154E:E:F115 E:E:T112 1003.89YesYes400
155E:E:F115 E:E:F196 64.238336.44YesYes400
156E:E:T112 E:E:Y114 1002.5YesYes400
157E:E:Y114 R:R:E717 10013.47YesYes409
158E:E:F115 R:R:E717 1003.5YesYes409
159R:R:E717 R:R:K720 10013.5YesNo099
160R:R:K720 R:R:L721 10011.28NoYes099
161E:E:E149 E:E:L145 10010.6YesNo000
162E:E:A150 E:E:L145 1001.58NoNo000
163E:E:A150 R:R:P604 1003.74NoYes009
164E:E:P322 E:E:R326 1004.32YesYes3000
165E:E:P322 E:E:V327 1003.53YesNo000
166E:E:L448 E:E:V327 1002.98NoNo000
167E:E:Q346 E:E:W330 11.63754.38NoYes000
168E:E:L448 E:E:Y444 1005.86NoYes3100
169E:E:G331 E:E:Y444 54.2952.9NoYes3100
170E:E:G331 E:E:Y435 52.35822.9NoYes3100
171E:E:I439 E:E:Y444 54.2959.67NoYes3100
172E:E:I439 E:E:Y435 52.358214.51NoYes3100
173E:E:M334 E:E:Y435 89.21216.76YesYes000
174E:E:M334 E:E:M430 44.65484.33YesYes000
175E:E:M334 E:E:S434 1003.07YesNo000
176E:E:F347 E:E:S434 93.08297.93NoNo000
177E:E:F347 E:E:L351 58.17626.09NoNo000
178E:E:F347 E:E:F438 29.090117.15NoNo000
179E:E:L351 E:E:L360 34.90674.15NoNo000
180E:E:F350 E:E:L351 17.45537.31NoNo000
181E:E:F350 E:E:F438 17.45429.65NoNo000
182E:E:E354 E:E:F350 23.27235.83NoNo000
183E:E:E354 E:E:S356 11.63614.31NoNo000
184E:E:I426 E:E:N359 19.42029.91YesNo3200
185E:E:E358 E:E:N359 17.478415.77NoNo000
186E:E:E358 E:E:R361 15.53643.49NoNo000
187E:E:R361 E:E:S357 13.59446.59NoNo000
188E:E:L360 E:E:L364 23.2728.3NoNo000
189E:E:E367 E:E:L364 17.45467.95NoNo000
190E:E:D368 E:E:E367 11.646.5NoNo000
191E:E:A365 E:E:D368 13.57463.09NoNo000
192E:E:F388 E:E:I397 38.7936.28NoYes500
193E:E:E387 E:E:F388 31.034422.15YesNo500
194E:E:E383 E:E:E387 19.39792.54NoYes500
195E:E:E383 E:E:R380 15.51799.3NoYes500
196E:E:D368 E:E:R380 15.52345.96NoYes000
197E:E:F419 E:E:I384 19.39887.54YesYes500
198E:E:I384 E:E:R380 15.52217.52YesYes500
199E:E:L389 E:E:W385 27.154719.36YesYes500
200E:E:F419 E:E:T418 34.914218.16YesYes500
201E:E:L389 E:E:Y404 11.63832.34YesYes500
202E:E:I397 E:E:L399 34.91292.85YesYes500
203E:E:L399 E:E:Y404 11.63788.21YesYes500
204E:E:L389 E:E:T407 11.638310.32YesYes500
205E:E:L399 E:E:T407 11.63784.42YesYes500
206E:E:N410 E:E:T418 27.15752.92NoYes000
207E:E:K406 E:E:N410 23.27792.8YesNo000
208E:E:R437 E:E:S434 23.27273.95NoNo000
209E:E:D433 E:E:R437 11.63647.15NoNo000
210E:E:E352 E:E:S357 11.65241.44NoNo000
211R:R:L721 R:R:Y722 1002.34YesYes1199
212R:R:I761 R:R:Y722 1003.63NoYes1189
213R:R:I761 R:R:P762 1005.08NoNo089
214R:R:P762 T:T:Y114 1008.34NoYes097
215T:T:F115 T:T:Y114 1009.28YesYes3477
216T:T:F115 T:T:F196 10036.44YesYes3479
217T:T:F196 T:T:W197 1008.02YesYes099
218T:T:W197 T:T:Y128 1008.68YesYes098
219T:T:E149 T:T:Y128 1003.37YesYes098
220T:T:E149 T:T:Y148 10023.57YesYes2398
221T:T:V203 T:T:Y148 1006.31NoYes2398
222T:T:V203 T:T:V98 1004.81NoYes097
223T:T:D96 T:T:V98 1002.92NoYes097
224T:T:D96 T:T:P93 1003.22NoNo099
225T:T:P93 T:T:Y108 1002.78NoYes098
226T:T:F57 T:T:Y108 10010.32YesYes058
227T:T:F57 T:T:I41 1008.79YesYes5558
228T:T:I41 T:T:W65 1007.05YesYes086
229T:T:L70 T:T:W65 1002.28NoYes076
230T:T:I72 T:T:L70 1002.85NoNo057
231T:T:E77 T:T:I72 1005.47YesNo095
232F:F:I362 T:T:E77 1008.2YesYes1449
233F:F:R359 T:T:E77 10012.79YesYes1469
234F:F:N350 F:F:R359 10010.85YesYes1466
235F:F:N350 F:F:W352 1004.52YesYes1469
236F:F:W352 F:F:Y319 1007.72YesYes096
237F:F:V354 F:F:Y319 1002.52NoYes056
238F:F:L355 F:F:V354 1005.96YesNo075
239F:F:L355 F:F:R338 1006.07YesYes2679
240F:F:R338 T:T:L297 1003.64YesYes2694
241T:T:D294 T:T:L297 1009.5YesYes094
242T:T:D294 T:T:F296 1005.97YesYes094
243F:F:A395 T:T:F296 1002.77NoYes084
244F:F:A395 F:F:R98 1005.53NoNo087
245F:F:R98 T:T:L307 1009.72NoNo074
246T:T:L307 T:T:N304 1006.87NoNo049
247T:T:N304 T:T:W306 1004.52NoYes098
248F:F:S134 T:T:W306 1004.94NoYes868
249F:F:I120 F:F:S134 1003.1NoNo056
250F:F:I120 F:F:W132 1007.05NoYes059
251F:F:I130 F:F:W132 1009.4NoYes089
252F:F:I130 F:F:K128 1002.91NoNo087
253F:F:D126 F:F:K128 1004.15YesNo097
254F:F:D126 F:F:N106 1008.08YesNo096
255F:F:N106 F:F:Q125 1005.28NoNo069
256F:F:Q125 F:F:W149 10024.09NoYes099
257F:F:W149 T:T:D213 99.579611.17YesNo1299
258F:F:I362 F:F:N350 1007.08YesYes1446
259F:F:R338 F:F:S336 1003.95YesNo099
260F:F:S336 T:T:D294 10011.78NoYes099
261F:F:F93 T:T:L297 1004.87YesYes034
262F:F:F93 F:F:M95 10012.44YesNo035
263F:F:A395 F:F:M95 1004.83NoNo085
264T:T:D213 T:T:K215 98.85786.91NoYes1299
265F:F:Y197 T:T:K215 80.80593.58YesYes1289
266F:F:L241 T:T:K215 16.11942.82NoYes089
267F:F:L340 F:F:Y319 15.93472.34NoYes076
268F:F:F333 F:F:L340 15.70066.09NoNo087
269F:F:F333 F:F:Y290 14.96975.16NoYes8486
270F:F:S292 F:F:Y290 13.4462.54NoYes056
271F:F:D294 F:F:S292 11.20758.83NoNo035
272F:F:D294 F:F:G293 10.7113.35NoNo038
273F:F:G293 F:F:P247 10.46224.06NoNo084
274F:F:P247 F:F:Y289 10.21335.56NoYes046
275T:T:N304 T:T:P305 1003.26NoNo099
276T:T:F313 T:T:P305 1004.33YesNo839
277T:T:D301 T:T:F313 1007.17NoYes063
278T:T:D301 T:T:Q325 1005.22NoNo066
279T:T:P305 T:T:W314 10027.02NoYes897
280F:F:R99 T:T:W306 29.86925NoYes878
281F:F:T380 T:T:W306 1007.28NoYes858
282F:F:F135 F:F:R99 29.19124.28YesNo847
283F:F:D378 T:T:W314 1003.35YesYes887
284F:F:D378 F:F:T380 10013.01YesNo885
285F:F:D378 F:F:K117 10013.83YesNo085
286F:F:K117 T:T:E317 1004.05NoNo056
287T:T:Q325 T:T:S323 10011.55NoNo064
288T:T:R326 T:T:S323 1005.27YesNo094
289T:T:E317 T:T:R326 10015.12NoYes069
290T:T:P322 T:T:R326 1005.76NoYes059
291T:T:R326 T:T:V342 10.89365.23YesYes4794
292T:T:P322 T:T:V327 1003.53NoNo059
293T:T:D340 T:T:R326 1008.34YesYes4799
294T:T:L448 T:T:V327 1002.98NoNo089
295T:T:L448 T:T:Y444 1005.86NoYes3689
296T:T:G331 T:T:Y444 60.97042.9NoYes3669
297T:T:G331 T:T:Y435 58.79342.9NoYes3669
298T:T:I439 T:T:Y444 60.97049.67NoYes3689
299T:T:I439 T:T:Y435 58.793414.51NoYes3689
300T:T:M334 T:T:Y435 10016.76YesYes059
301T:T:D340 T:T:P341 1008.05YesNo095
302T:T:P341 T:T:R344 1002.88NoNo056
303T:T:L338 T:T:R344 1006.07NoNo086
304T:T:L338 T:T:W363 1003.42NoYes086
305T:T:M430 T:T:W363 1009.31YesYes3796
306T:T:M334 T:T:M430 50.12434.33YesYes059
307T:T:M334 T:T:S434 1003.07YesNo059
308T:T:F347 T:T:S434 1007.93NoNo099
309T:T:F347 T:T:L351 65.32916.09NoNo098
310T:T:F347 T:T:F438 32.666317.15NoNo098
311T:T:L351 T:T:L360 39.19914.15NoNo089
312T:T:F350 T:T:L351 19.60127.31NoNo098
313T:T:F350 T:T:F438 19.69.65NoNo098
314T:T:E354 T:T:F350 26.13325.83NoNo099
315T:T:E354 T:T:S356 13.06664.31NoNo099
316T:T:I426 T:T:M430 1005.83YesYes3789
317T:T:I426 T:T:N359 21.79959.91YesNo3789
318T:T:E358 T:T:N359 19.619815.77NoNo099
319T:T:E358 T:T:R361 17.43993.49NoNo096
320T:T:R361 T:T:S357 15.25996.59NoNo067
321T:T:L360 T:T:L364 26.1348.3NoNo095
322T:T:Q423 T:T:W363 10010.95NoYes096
323T:T:Q423 T:T:V366 10014.33NoNo098
324T:T:F362 T:T:V366 1007.87NoNo098
325T:T:F362 T:T:I426 1007.54NoYes098
326T:T:F362 T:T:I397 1007.54NoYes098
327T:T:E367 T:T:L364 19.60147.95NoNo075
328T:T:D368 T:T:E367 13.0716.5NoNo057
329T:T:A365 T:T:D368 15.24343.09NoNo085
330T:T:F388 T:T:I397 43.55956.28NoYes668
331T:T:E387 T:T:F388 34.847622.15YesNo696
332T:T:E383 T:T:E387 21.78132.54NoYes659
333T:T:E383 T:T:R380 17.42439.3NoYes656
334T:T:D368 T:T:R380 17.43045.96NoYes056
335T:T:I397 T:T:L389 1008.56YesYes689
336T:T:F419 T:T:L389 1002.44YesYes659
337T:T:F419 T:T:I384 21.78197.54YesYes659
338T:T:I384 T:T:R380 17.42937.52YesYes696
339T:T:K370 T:T:Q423 48.02665.42NoNo089
340T:T:K370 T:T:R416 45.84942.48NoNo089
341T:T:F419 T:T:V381 1003.93YesYes658
342T:T:P414 T:T:V381 95.8337.07YesYes668
343T:T:P414 T:T:V377 78.41083.53YesNo669
344T:T:I374 T:T:V377 74.05496.14NoNo059
345F:F:Q228 T:T:I374 69.69884.12NoNo055
346F:F:Q228 F:F:S226 65.34277.22NoYes056
347F:F:D223 F:F:S226 39.20575.89NoYes096
348F:F:D223 T:T:P373 34.84964.83NoYes097
349T:T:P373 T:T:R372 13.06872.88YesNo5775
350F:F:M208 T:T:P373 17.42496.71YesYes5737
351F:F:E225 F:F:S226 17.42485.75NoYes076
352F:F:E225 T:T:K375 13.068613.5NoNo074
353T:T:L389 T:T:W385 30.491419.36YesYes696
354T:T:F419 T:T:T418 39.204318.16YesYes655
355T:T:L389 T:T:Y404 13.06832.34YesYes694
356T:T:I397 T:T:L399 39.20292.85YesYes687
357T:T:L399 T:T:Y404 13.06788.21YesYes674
358T:T:L389 T:T:T407 13.068310.32YesYes699
359T:T:L399 T:T:T407 13.06784.42YesYes679
360T:T:N410 T:T:T418 30.49442.92NoYes085
361T:T:K406 T:T:N410 26.13812.8YesNo038
362T:T:R416 T:T:Y417 17.420711.32NoNo097
363F:F:Q209 T:T:R416 26.25215.19NoNo059
364F:F:R269 T:T:Y417 13.067616.46NoNo097
365T:T:R437 T:T:S434 26.13373.95NoNo099
366T:T:D433 T:T:R437 13.06697.15NoNo099
367T:T:E352 T:T:S357 13.081.44NoNo077
368T:T:E352 T:T:S353 10.91.44NoNo079
369F:F:F135 F:F:R118 16.055610.69YesNo846
370F:F:D116 F:F:R118 15.32611.91NoNo086
371F:F:R119 F:F:Y155 13.13685.14NoYes067
372F:F:D126 F:F:G127 28.4915.03YesNo099
373F:F:G127 F:F:V150 27.76071.84NoYes099
374F:F:M145 F:F:V150 18.263910.65YesYes8689
375F:F:M145 F:F:P146 16.07345.03YesNo085
376F:F:K188 F:F:P146 13.88183.35YesNo045
377F:F:N196 F:F:Y197 38.583711.63NoYes1288
378F:F:N196 F:F:S214 37.8565.96NoYes1289
379F:F:H194 F:F:S214 36.40075.58NoYes1299
380F:F:H194 F:F:T218 34.94482.74NoYes1297
381F:F:H234 F:F:T218 66.977819.17NoYes037
382F:F:H234 F:F:S232 64.06594.18NoNo035
383F:F:L229 F:F:S232 61.15393NoNo055
384F:F:L229 F:F:W222 55.329914.81NoYes3859
385F:F:T212 F:F:W222 49.5067.28YesYes3899
386F:F:I210 F:F:T212 34.94563.04NoYes069
387F:F:F203 F:F:I210 23.29723.77NoNo096
388F:F:G215 F:F:Y197 38.58364.35YesYes1288
389F:F:G215 F:F:S214 37.85723.71YesYes1289
390F:F:D216 F:F:S214 37.85677.36YesYes1299
391F:F:D216 F:F:T218 34.944810.12YesYes1297
392F:F:F203 F:F:P157 17.4732.89NoNo096
393F:F:D207 F:F:P157 14.56096.44YesNo086
394F:F:K188 F:F:Y174 10.959714.33YesNo8746
395F:F:A185 F:F:Y174 10.22924NoNo036
396F:F:L241 F:F:S199 15.39296.01NoNo089
397F:F:A213 F:F:S199 14.66661.71NoNo079
398F:F:Q209 F:F:T204 19.72365.67NoNo055
399F:F:L211 F:F:T204 13.19432.95NoNo065
400F:F:F254 F:F:L211 11.017915.83NoNo086
401F:F:R269 F:F:S270 10.89115.27NoNo094
402F:F:A213 F:F:C219 10.30961.81NoNo078
403R:R:P604 R:R:V603 1003.53YesNo7799
404R:R:S605 R:R:V603 1004.85NoNo099
405R:R:A606 R:R:S605 1001.71NoNo099
406R:R:A606 R:R:F607 1006.93NoNo098
407R:R:F607 R:R:S446 1005.28NoYes088
408R:R:K666 R:R:S446 1006.12NoYes098
409R:R:K666 R:R:S450 1004.59NoNo9499
410R:R:K502 R:R:S450 1001.53YesNo099
411R:R:K502 R:R:M613 1005.76YesNo097
412R:R:L662 R:R:M613 1007.07NoNo087
413R:R:L661 R:R:L662 1001.38NoNo088
414R:R:L661 R:R:V657 1002.98NoNo087
415R:R:N619 R:R:V657 1005.91NoNo097
416R:R:I623 R:R:N619 1007.08YesNo059
417R:R:H650 R:R:I623 1003.98YesYes095
418R:R:F627 R:R:H650 46.441114.71YesYes099
419R:R:F627 R:R:L646 21.72974.87YesNo098
420R:R:L646 R:R:R631 20.91983.64NoNo089
421R:R:F632 R:R:R631 41.3126.41NoNo099
422R:R:D579 R:R:F632 32.62673.58NoNo099
423R:R:D579 R:R:R485 31.550313.1NoYes099
424R:R:C481 R:R:R485 20.17232.79NoYes099
425R:R:C481 R:R:C573 14.72057.28NoNo9599
426R:R:C573 R:R:P476 14.17681.88NoNo099
427R:R:E475 R:R:P476 13.63171.57NoNo059
428R:R:E475 R:R:R480 13.08663.49NoNo059
429R:R:F474 R:R:R480 10.36087.48NoNo089
430R:R:F627 R:R:Y647 23.90385.16YesYes095
431R:R:R631 R:R:Y647 20.934313.38NoYes095
432R:R:I623 R:R:T654 16.81624.56YesNo059
433R:R:T654 R:R:Y496 14.37612.5NoYes4099
434R:R:V495 R:R:Y496 12.05196.31NoYes089
435R:R:S462 R:R:V495 11.77831.62NoNo098
436R:R:H650 R:R:R488 72.98247.9YesYes099
437R:R:R485 R:R:W544 10.407513YesYes099
438R:R:E586 R:R:R488 67.57155.82YesYes099
439R:R:E586 R:R:T582 67.38834.23YesNo098
440R:R:F540 R:R:T582 67.11812.59NoNo098
441R:R:F540 S:S:W539 66.8484.01NoNo099
442S:S:F540 S:S:W539 66.30816.01NoNo099
443S:S:F540 S:S:W578 64.95824.01NoYes099
444R:R:G543 S:S:W578 15.52115.63NoYes089
445R:R:G543 R:R:S546 15.24963.71NoNo086
446R:R:S546 S:S:R577 14.97865.27NoNo068
447S:S:R577 S:S:Y580 13.365110.29NoNo088
448S:S:I575 S:S:Y580 13.12242.42NoNo068
449S:S:I575 S:S:L574 12.84934.28NoNo067
450S:S:K563 S:S:L574 12.57614.23YesNo047
451S:S:K563 S:S:Q561 10.6641.36YesNo045
452S:S:G562 S:S:Q561 10.11761.64NoNo075
453S:S:W544 S:S:W578 45.74039.37YesYes099
454S:S:R485 S:S:W544 44.38478NoYes099
455S:S:D579 S:S:R485 43.842816.68NoNo099
456S:S:D579 S:S:F632 20.70192.39NoNo099
457S:S:F632 S:S:R631 20.48716.41NoNo099
458S:S:R631 S:S:Y647 20.215311.32NoYes095
459S:S:F627 S:S:Y647 17.224515.47YesYes095
460S:S:F627 S:S:H650 15.579741.86YesNo099
461S:S:H650 S:S:T651 15.30682.74NoNo098
462S:S:T651 S:S:Y466 15.03374.99NoYes088
463S:S:D579 S:S:T582 22.87837.23NoNo098
464S:S:L489 S:S:T582 22.6064.42NoNo078
465S:S:L489 S:S:R488 22.33412.43NoNo079
466S:S:E586 S:S:R488 21.79042.33YesNo099
467S:S:E586 S:S:S624 19.88254.31YesNo4299
468S:S:E620 S:S:S624 19.67245.75YesNo4299
469S:S:E620 S:S:Y496 15.57614.59YesYes4299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EWR
Class C
SubFamily Orphan
Type Orphan
SubType GPR158
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners B5; RGS7
PDB Resolution 4.7
Date 2021-12-01
D.O.I. 10.1038/s41467-021-27147-1
Net Summary
Imin 2.28
Number of Linked Nodes 2369
Number of Links 2861
Number of Hubs 441
Number of Links mediated by Hubs 1574
Number of Communities 102
Number of Nodes involved in Communities 706
Number of Links involved in Communities 982
Path Summary
Number Of Nodes in MetaPath 470
Number Of Links MetaPath 469
Number of Shortest Paths 182498727
Length Of Smallest Path 3
Average Path Length 135.983
Length of Longest Path 134
Minimum Path Strength 1.205
Average Path Strength 8.89166
Maximum Path Strength 41.725
Minimum Path Correlation 0.85
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 7.22892
Average % Of Corr. Nodes 113.801
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 88.7741
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• pyrophosphatase activity   • enzyme regulator activity   • GTPase activity   • molecular function activator activity   • nucleoside-triphosphatase regulator activity   • hydrolase activity   • GTPase regulator activity   • enzyme activator activity   • ribonucleoside triphosphate phosphatase activity   • GTPase activator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • protein binding   • binding   • G-protein beta-subunit binding   • G-protein alpha-subunit binding   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of hydrolase activity   • regulation of catalytic activity   • regulation of hydrolase activity   • biological regulation   • positive regulation of catalytic activity   • regulation of GTPase activity   • positive regulation of GTPase activity   • response to stimulus   • response to alcohol   • response to chemical   • response to oxygen-containing compound   • response to ethanol
Gene OntologyBiological Process• positive regulation of molecular function   • regulation of molecular function   • positive regulation of hydrolase activity   • regulation of catalytic activity   • regulation of hydrolase activity   • biological regulation   • positive regulation of catalytic activity   • regulation of GTPase activity   • positive regulation of GTPase activity   • response to stimulus   • response to alcohol   • response to chemical   • response to oxygen-containing compound   • response to ethanol   • response to amine   • response to nitrogen compound   • response to amphetamine   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell communication   • regulation of signaling   • negative regulation of signaling   • negative regulation of response to stimulus   • negative regulation of biological process   • regulation of signal transduction   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • regulation of response to stimulus   • negative regulation of cellular process   • regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • intracellular signal transduction   • regulation of localization   • positive regulation of cation transmembrane transport   • regulation of potassium ion transport   • transport   • monoatomic ion transmembrane transport   • positive regulation of biological process   • potassium ion transmembrane transport   • regulation of monoatomic ion transmembrane transport   • metal ion transport   • monoatomic cation transmembrane transport   • localization   • positive regulation of monoatomic ion transport   • positive regulation of transmembrane transport   • monoatomic ion transport   • positive regulation of monoatomic ion transmembrane transport   • monoatomic cation transport   • regulation of metal ion transport   • positive regulation of cellular process   • regulation of transport   • regulation of monoatomic ion transport   • inorganic ion transmembrane transport   • regulation of potassium ion transmembrane transport   • establishment of localization   • inorganic cation transmembrane transport   • transmembrane transport   • positive regulation of potassium ion transport   • regulation of transmembrane transport   • positive regulation of transport   • positive regulation of potassium ion transmembrane transport   • regulation of monoatomic cation transmembrane transport   • potassium ion transport   • membrane-bounded organelle   • intracellular organelle   • organelle envelope   • cellular anatomical structure   • intracellular anatomical structure   • organelle   • nuclear envelope   • nucleus   • intracellular membrane-bounded organelle   • endomembrane system   • cytoplasm   • cytosol   • cell periphery   • plasma membrane
Gene OntologyCellular Component• membrane-bounded organelle   • intracellular organelle   • organelle envelope   • cellular anatomical structure   • intracellular anatomical structure   • organelle   • nuclear envelope   • nucleus   • intracellular membrane-bounded organelle   • endomembrane system   • cytoplasm   • cytosol   • cell periphery   • plasma membrane   • membrane   • protein-containing complex   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • protein binding   • binding   • G-protein gamma-subunit binding   • pyrophosphatase activity   • enzyme regulator activity   • GTPase activity   • molecular function activator activity   • nucleoside-triphosphatase regulator activity   • hydrolase activity   • GTPase regulator activity   • enzyme activator activity   • ribonucleoside triphosphate phosphatase activity   • GTPase activator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • protein-folding chaperone binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • cellular response to stimulus   • response to light stimulus   • dark adaptation   • response to light intensity   • cellular response to absence of light   • response to stimulus   • cellular response to light intensity   • cellular response to radiation   • response to absence of light   • cellular response to environmental stimulus   • cellular response to light stimulus   • response to radiation   • response to abiotic stimulus   • cellular process   • cellular response to abiotic stimulus   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of hydrolase activity   • regulation of catalytic activity   • regulation of hydrolase activity   • biological regulation   • positive regulation of catalytic activity   • regulation of GTPase activity   • positive regulation of GTPase activity   • cellular response to nitrogen compound   • response to dopamine   • regulation of cellular process   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • G protein-coupled receptor signaling pathway   • regulation of calcium ion transmembrane transporter activity   • regulation of calcium ion transport   • regulation of localization   • negative regulation of voltage-gated calcium channel activity   • negative regulation of ion transmembrane transporter activity   • negative regulation of calcium ion transmembrane transporter activity   • negative regulation of biological process   • negative regulation of transport   • regulation of voltage-gated calcium channel activity   • calcium ion transport   • localization   • negative regulation of cation transmembrane transport   • monoatomic cation transport   • regulation of monoatomic ion transport   • inorganic ion transmembrane transport   • establishment of localization   • regulation of cation channel activity   • inorganic cation transmembrane transport   • transmembrane transport   • regulation of transmembrane transport   • negative regulation of calcium ion transmembrane transport   • transport   • negative regulation of cation channel activity   • monoatomic ion transmembrane transport   • negative regulation of monoatomic ion transport   • regulation of transmembrane transporter activity   • regulation of monoatomic ion transmembrane transport   • metal ion transport   • negative regulation of transmembrane transport   • regulation of transporter activity   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • negative regulation of monoatomic ion transmembrane transport   • negative regulation of cellular process   • monoatomic ion transport   • regulation of metal ion transport   • regulation of monoatomic ion transmembrane transporter activity   • regulation of transport   • negative regulation of transporter activity   • negative regulation of molecular function   • negative regulation of calcium ion transport   • regulation of monoatomic cation transmembrane transport   • calcium ion transmembrane transport   • light adaption   • cell tip   • cell pole   • postsynapse   • postsynaptic membrane   • synapse   • cell junction   • plasma membrane region   • synaptic membrane   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • presynapse   • presynaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • GTPase activator complex   • enzyme activator complex   • neurotransmitter receptor activity   • G protein-coupled glycine receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled neurotransmitter receptor activity   • developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • regulation of signaling   • regulation of signal transduction   • regulation of response to stimulus   • regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • cellular localization   • modulation of chemical synaptic transmission   • positive regulation of neurotransmitter secretion   • positive regulation of biological process   • positive regulation of secretion by cell   • synaptic signaling   • regulation of secretion by cell   • secretion by cell   • positive regulation of secretion   • signal release   • establishment of localization in cell   • positive regulation of cellular process   • trans-synaptic signaling   • positive regulation of neurotransmitter transport   • neurotransmitter secretion   • secretion   • regulation of neurotransmitter transport   • export from cell   • cell-cell signaling   • positive regulation of synaptic transmission   • neurotransmitter transport   • regulation of secretion   • chemical synaptic transmission   • signal release from synapse   • regulation of trans-synaptic signaling   • positive regulation of transport   • regulation of neurotransmitter secretion   • anterograde trans-synaptic signaling   • positive regulation of signaling   • protein localization   • protein localization to cell periphery   • protein localization to plasma membrane   • cellular macromolecule localization   • macromolecule localization   • localization within membrane   • protein localization to membrane   • system process   • nervous system process   • cognition   • regulation of cellular component organization   • cellular component organization   • regulation of synapse organization   • cell junction organization   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of biological quality   • postsynaptic specialization membrane   • postsynaptic specialization   • postsynaptic density membrane   • postsynaptic density   • neuron to neuron synapse   • asymmetric synapse
SCOP2Domain Identifier• Regulator of G-protein signaling, RGS   • WD40 repeat-like
SCOP2Family Identifier• Regulator of G-protein signaling, RGS   • WD40 repeat-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtO14775
Sequence
>7EWR_Chain_B
LKSEAESLK GKLEEERAK LHDVELHQV AERVEALGQ FVMKTRRTL 
KGHGNKVLC MDWCKDKRR IVSSSQDGK VIVWDSFTT NKEHAVTMP 
CTWVMACAY APSGCAIAC GGLDNKCSV YPLTFDKNE NMAAKKKSV 
AMHTNYLSA CSFTNSDMQ ILTASGDGT CALWDVESG QLLQSFHGH 
GADVLCLDL APSETGNTF VSGGCDKKA MVWDMRSGQ CVQAFETHE 
SDINSVRYY PSGDAFASG SDDATCRLY DLRADREVA IYSKESIIF 
GASSVDFSL SGRLLFAGY NDYTINVWD VLKGSRVSI LFGHENRVS 
TLRVSPDGT AFCSGSWDH TLRVWA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainE
ProteinRGP
UniProtP49802
Sequence
>7EWR_Chain_E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainF
ProteinG Protein β Sub unit
UniProtO14775
Sequence
>7EWR_Chain_F
DVELHQVAE RVEALGQFV MKTRRTLKG HGNKVLCMD WCKDKRRIV 
SSSQDGKVI VWDSFTTNK EHAVTMPCT WVMACAYAP SGCAIACGG 
LDNKCSVYP LTFDKNENM AAKKKSVAM HTNYLSACS FTNSDMQIL 
TASGDGTCA LWDVESGQL LQSFHGHGA DVLCLDLAP SETGNTFVS 
GGCDKKAMV WDMRSGQCV QAFETHESD INSVRYYPS GDAFASGSD 
DATCRLYDL RADREVAIY SKESIIFGA SSVDFSLSG RLLFAGYND 
YTINVWDVL KGSRVSILF GHENRVSTL RVSPDGTAF CSGSWDHTL 
RVWA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T848
Sequence
>7EWR_Chain_R
LAQKLAEEV PMDVASYLY TGDSHQLKR ANCSGRYEL AGLPGKWPA 
LASAHPSLH RALDTLTHA TNFLNVMLQ SNKSREQNL QDDLDWYQA 
LVWSLLEGE PSISRAAIT FSTQVFLQA TREESRILL QDPHLANAT 
LETSHFKWS PPYLECENG SYKPGWLVT LSSAIYGLL VPEFRGVMK 
VDINLQKVD IDQCSSDGW FSGTHKCHL NNSECMPIK GLGFVLGAY 
ECICKAGFY HPAYVCLPC REGCPFCAD DSPCFVQED KYLRLAIIS 
FQALCMLLD FVSMLVVYH FRKAKSIRA SGLILLETI LFGSLLLYF 
PVVILYFEP STFRCILLR WARLLGFAT VYGTVTLKL HRVLKVFLS 
RTAQRIPYM TGGRVMRML AVILLVVFW FLIGWTSSV CQNLEKQIS 
LIGQGKTSD HLIFNMCLI DRWDYMTAV AEFLFLLWG VYLCYAVRT 
VPSAFHEPR YMAVAVHNE LIISAIFHT IRFVLASRL QSDWMLMLY 
FAHTHLTVT VTIGLLLIP KFSAWSEHS LDPEDIRDE LKKLYAQLE 
IYKRKKMIT NNPHLQKKR CSKKGLGRS IMRRITEIP E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ5T848
Sequence
>7EWR_Chain_S
LAQKLAEEV PMDVASYLY TGDSHQLKR ANCSGRYEL AGLPGKWPA 
LASAHPSLH RALDTLTHA TNFLNVMLQ SNKSREQNL QDDLDWYQA 
LVWSLLEGE PSISRAAIT FSTQVFLQA TREESRILL QDPHLANAT 
LETSHFKWS PPYLECENG SYKPGWLVT LSSAIYGLL VPEFRGVMK 
VDINLQKVD IDQCSSDGW FSGTHKCHL NNSECMPIK GLGFVLGAY 
ECICKAGFY HPAYVCLPC REGCPFCAD DSPCFVQED KYLRLAIIS 
FQALCMLLD FVSMLVVYH FRKAKSIRA SGLILLETI LFGSLLLYF 
PVVILYFEP STFRCILLR WARLLGFAT VYGTVTLKL HRVLKVFLS 
RTAQRIPYM TGGRVMRML AVILLVVFW FLIGWTSSV CQNLEKQIS 
LIGQGKTSD HLIFNMCLI DRWDYMTAV AEFLFLLWG VYLCYAVRT 
VPSAFHEPR YMAVAVHNE LIISAIFHT IRFVLASRL QSDWMLMLY 
FAHTHLTVT VTIGLLLIP KFSAWSEHS LDPEDIRDE LKKLYAQLE 
IYKRKKMIT NNPHLQKKR CSKKGLGRS IMRRITEIP ELSSSA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SHECOrphanOrphanGPR158Homo sapiens-PI; PE-3.42021-12-0110.1126/science.abl4732
7EWLCOrphanOrphanGPR158Homo sapiens---3.522021-12-0110.1038/s41467-021-27147-1
7SHFCOrphanOrphanGPR158Homo sapiens-PI; PEB5; RGS73.42021-12-0110.1126/science.abl4732
7EWRCOrphanOrphanGPR158Homo sapiens--B5; RGS74.72021-12-0110.1038/s41467-021-27147-1
7EWPCOrphanOrphanGPR158Homo sapiens--B5; RGS74.32021-12-0110.1038/s41467-021-27147-1




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