Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:L68 4.6625457
2B:B:D77 6.0575408
3B:B:V87 4.13413
4B:B:F93 4.3875403
5B:B:R99 4.0175417
6B:B:H104 6.904519
7B:B:N106 8.1425416
8B:B:K107 9.39419
9B:B:M111 3.885616
10B:B:W113 5.1525818
11B:B:C114 5.1175415
12B:B:R118 8.2425416
13B:B:R119 6.51416
14B:B:I120 6.23415
15B:B:I130 9.3825418
16B:B:W132 9.476519
17B:B:F135 4.47571714
18B:B:H141 7.03405
19B:B:M145 4.335218
20B:B:W149 9.56333619
21B:B:Y155 4.00833617
22B:B:Y174 6.347147206
23B:B:V191 3.37498
24B:B:H194 7.362599
25B:B:Y197 5.03167618
26B:B:F203 4.34409
27B:B:S206 3.924535
28B:B:Q209 7.046535
29B:B:L211 4.768536
30B:B:D216 9.0725499
31B:B:L221 3.1025436
32B:B:W222 6.64167699
33B:B:F233 5.902537
34B:B:H236 6.50333639
35B:B:N252 4.72435
36B:B:F254 6.285638
37B:B:D260 4.88409
38B:B:W266 9.644539
39B:B:M268 3.19535
40B:B:R269 9.235439
41B:B:Q275 6.22167658
42B:B:F277 4.448559
43B:B:H280 8.45759
44B:B:R288 6.1414
45B:B:Y289 5.606556
46B:B:Y290 5.17143716
47B:B:P291 6.27418
48B:B:F296 4.87656
49B:B:D302 7.6125459
50B:B:T304 6.355456
51B:B:R306 8.14658
52B:B:Y308 6.65143756
53B:B:R311 8.575229
54B:B:D313 3.985458
55B:B:E315 5.9225457
56B:B:Y319 3.90429706
57B:B:I324 3.285414
58B:B:F326 4.316506
59B:B:F333 3.706518
60B:B:R338 4.89375819
61B:B:L339 4.0475415
62B:B:L340 3.03417
63B:B:F341 4.838516
64B:B:Y344 5.21857718
65B:B:Y347 4.035414
66B:B:T348 6.43415
67B:B:I349 3.145415
68B:B:N350 6.942516
69B:B:V351 4.41415
70B:B:W352 4.682519
71B:B:L355 3.114517
72B:B:R359 6.334516
73B:B:I362 5.738514
74B:B:F364 5.145414
75B:B:H366 6.415619
76B:B:N368 4.03517
77B:B:R369 8.1125419
78B:B:L373 4.255417
79B:B:R374 4.532515
80B:B:D378 9.59418
81B:B:T380 8.2075415
82B:B:F382 6.29515
83B:B:C383 3.722515
84B:B:S384 4.155418
85B:B:W387 11.05518
86B:B:D388 6.87519
87B:B:L391 4.5125417
88B:B:R392 4.39516
89B:B:W394 6.405618
90E:E:Y24 4.21764
91E:E:M27 4.49468
92E:E:E28 7.9325468
93E:E:I31 4.0575465
94E:E:M34 4.9325468
95E:E:I41 4.48468
96E:E:P54 5.0875408
97E:E:S55 2.9525449
98E:E:F57 6.905465
99E:E:W65 7.51566
100E:E:L66 2.6875405
101E:E:I72 4.43415
102E:E:E77 5.636519
103E:E:H80 5.2925419
104E:E:H88 6468
105E:E:Y90 6.96667669
106E:E:F91 2.944564
107E:E:F92 3.92286749
108E:E:H97 8.3954119
109E:E:L99 3.8725409
110E:E:L101 3.4625408
111E:E:Y108 4.37167608
112E:E:R109 4.3525849
113E:E:F110 6.76469
114E:E:T112 4.10333648
115E:E:Y114 7.122547
116E:E:F115 8.03167647
117E:E:W116 5.8667
118E:E:W121 6.35448
119E:E:Y128 6.388548
120E:E:Y131 6.024548
121E:E:M137 3.134239
122E:E:R142 4.55754249
123E:E:L143 3.0245169
124E:E:Y148 7.7625118
125E:E:E149 6.72254119
126E:E:F160 3.454128
127E:E:W164 7.22254129
128E:E:Q174 8.8025449
129E:E:D178 3.865409
130E:E:R181 8.985448
131E:E:I188 3.928548
132E:E:L189 5.7575448
133E:E:Q192 3.50333649
134E:E:E193 3.45449
135E:E:F196 11.8625449
136E:E:W197 9.55549
137E:E:H200 5.01449
138E:E:D213 6.3225419
139E:E:I214 9.005419
140E:E:K215 6.9925419
141E:E:W265 7.36143755
142E:E:Q268 6.74455
143E:E:R273 3.036554
144E:E:Y286 6.245415
145E:E:Y290 5.98286716
146E:E:Y293 6.13167617
147E:E:D294 6.31833619
148E:E:P295 4.355415
149E:E:F296 3.425414
150E:E:L297 5.2725414
151E:E:N304 6.176519
152E:E:W306 4.4861018
153E:E:F313 7.6275413
154E:E:W314 6.47125817
155E:E:Q325 4.775416
156E:E:R326 6.49254179
157E:E:K328 4.1625415
158E:E:R329 7.1775418
159E:E:W330 3.696179
160E:E:F332 7.3675418
161E:E:M334 5.555185
162E:E:D340 7.1154179
163E:E:F350 4.9325139
164E:E:L351 3.90254138
165E:E:E354 5.83754139
166E:E:L360 5.04754139
167E:E:F362 4.66609
168E:E:W363 7.326536
169E:E:P373 5.445437
170E:E:I374 3.13405
171E:E:E376 7.9725433
172E:E:V377 3.2975409
173E:E:R380 6.935436
174E:E:V381 3.88754148
175E:E:I384 4.345439
176E:E:W385 4.84833606
177E:E:F388 6.295406
178E:E:K406 4.82433
179E:E:R416 7.1875439
180E:E:Y417 4.814537
181E:E:F419 6.10754145
182E:E:E420 6.125436
183E:E:M430 3.38609
184E:E:Y435 7.014509
185R:R:R417 6.64754269
186R:R:L454 5.225489
187R:R:Y466 4.435408
188R:R:R480 8.59254279
189R:R:I482 2.2675407
190R:R:R485 6.4725429
191R:R:W486 5.406509
192R:R:R488 4.6429
193R:R:F492 7.255429
194R:R:V495 5.575408
195R:R:Y496 9.41667629
196R:R:L501 3.035409
197R:R:R505 4.2489
198R:R:F510 4.9654169
199R:R:P519 2.825409
200R:R:Y520 5.812588
201R:R:F540 3.726529
202R:R:W544 5.82729
203R:R:Q561 4.1725405
204R:R:I575 2.64426
205R:R:D576 5.6625428
206R:R:W578 4.975829
207R:R:M581 4.3675429
208R:R:E586 5.6475429
209R:R:W592 5.0975409
210R:R:V603 3.6654169
211R:R:F607 5.5825408
212R:R:E609 4.784589
213R:R:M613 5.7487
214R:R:F627 10.31529
215R:R:H628 3.736528
216R:R:R631 5.828529
217R:R:Y647 6.022525
218R:R:H650 11.0225409
219R:R:H652 8.6529
220R:R:V655 3.8175427
221R:R:I659 3.8425407
222R:R:K666 5.0125409
223R:R:I714 4.2725409
224R:R:E717 6.2825299
225R:R:K719 4.44409
226R:R:Y722 7.11549
227R:R:E726 8.205449
228R:R:K729 4.50833649
229R:R:N736 4.935449
230S:S:R417 4.8825409
231S:S:F423 4.9954155
232S:S:Q424 9.464159
233S:S:D431 2.6925306
234S:S:M435 4.0225409
235S:S:S450 4.0345109
236S:S:L454 4.268336109
237S:S:Y466 4.56714708
238S:S:R485 5.5025409
239S:S:W486 3.662529
240S:S:F492 5.57667679
241S:S:Y496 11.61479
242S:S:T498 2.9965109
243S:S:K502 4.67254109
244S:S:I518 4.15507
245S:S:W539 3.86429
246S:S:F540 3.78667629
247S:S:L541 4.0575429
248S:S:W544 6.314529
249S:S:L558 2.562506
250S:S:I559 2.71408
251S:S:I569 4.115405
252S:S:I575 3.7925476
253S:S:R577 6.2525408
254S:S:W578 5.01857729
255S:S:L596 3.528509
256S:S:F607 3.484508
257S:S:E609 5.23754109
258S:S:P610 3.8925409
259S:S:E620 9.972579
260S:S:F627 10.988579
261S:S:H628 4.766578
262S:S:R631 5.196579
263S:S:F632 6.23579
264S:S:L638 2.1525408
265S:S:Y647 6.216575
266S:S:F648 6.9454159
267S:S:H652 9.5665159
268S:S:K666 4.98254109
269S:S:L721 6.37409
270S:S:Y728 6.315407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:E60 B:B:L57 11.42131.33NoNo077
2B:B:E60 B:B:L64 11.94023.98NoNo578
3B:B:L64 E:E:W265 12.97834.56NoYes585
4B:B:L68 E:E:W265 10.71472.28YesYes575
5B:B:D313 E:E:R273 11.61693.57YesYes584
6B:B:D313 B:B:F277 17.46842.39YesYes589
7B:B:F277 B:B:F296 18.1155.36YesYes596
8B:B:F296 B:B:Y289 22.08292.06YesYes566
9B:B:D244 B:B:Y289 67.52314.6NoYes086
10B:B:D244 B:B:R288 67.69355.96NoYes084
11B:B:D332 B:B:R288 67.59088.34NoYes154
12B:B:D332 B:B:V375 86.57517.3NoNo056
13B:B:F382 B:B:V375 86.74372.62YesNo056
14E:E:D294 E:E:F296 10.88924.78YesYes194
15B:B:F382 B:B:W394 63.513512.03YesYes158
16B:B:R392 B:B:W394 32.03915YesYes168
17B:B:H104 B:B:S124 10.47656.97YesNo099
18B:B:D126 B:B:S124 10.524110.31NoNo099
19B:B:D126 B:B:N106 10.91965.39NoYes096
20B:B:K107 B:B:N106 10.99246.99YesYes196
21B:B:F382 B:B:L373 31.74796.09YesYes157
22B:B:L373 B:B:S384 35.07893YesYes178
23B:B:H366 B:B:S384 67.43875.58YesYes198
24B:B:D388 B:B:H366 99.851510.08YesYes199
25B:B:D388 B:B:N368 1002.69YesYes197
26B:B:S384 B:B:W394 32.02554.94YesYes188
27B:B:H366 B:B:R392 32.313.39YesYes196
28B:B:I162 B:B:Y174 10.17143.63NoYes086
29B:B:I162 B:B:Y155 11.21422.42NoYes087
30B:B:D112 B:B:Y155 14.50423.45NoYes077
31B:B:D112 B:B:R374 14.85364.76NoYes075
32B:B:G257 B:B:G258 44.1442.11NoNo078
33B:B:G258 B:B:H236 43.97173.18NoYes089
34B:B:H236 B:B:W266 40.17425.29YesYes399
35B:B:F254 B:B:W266 38.962215.03YesYes389
36B:B:F254 B:B:M268 33.40592.49YesYes385
37B:B:M268 E:E:Y417 24.88553.59YesYes357
38B:B:C242 B:B:V287 44.25145.12NoNo078
39B:B:V255 B:B:V287 44.42363.21NoNo068
40B:B:C305 B:B:Y319 11.34222.69NoYes086
41B:B:C305 B:B:Y344 11.50562.69NoYes088
42B:B:W352 B:B:Y319 11.57676.75YesYes096
43B:B:W352 B:B:Y344 11.50375.79YesYes198
44B:B:D346 B:B:Y344 23.82723.45NoYes088
45B:B:D346 B:B:F326 24.37817.17NoYes086
46B:B:N368 B:B:R369 99.94932.41YesYes179
47B:B:F326 E:E:H88 25.17614.53YesYes068
48B:B:R369 E:E:N20 1002.41YesNo098
49E:E:N20 E:E:Y24 1003.49NoYes084
50E:E:Y24 E:E:Y90 64.74382.98YesYes649
51E:E:P117 E:E:Y24 64.394811.13NoYes684
52E:E:W116 E:E:Y90 72.97517.72YesYes679
53E:E:P117 E:E:W116 64.40954.05NoYes687
54E:E:Q111 E:E:W116 1003.29NoYes097
55E:E:F92 E:E:Q111 41.65572.34YesNo099
56E:E:F92 E:E:R194 41.32633.21YesNo099
57E:E:F115 E:E:Q111 89.6385.86YesNo079
58E:E:F115 E:E:F196 41.004820.36YesYes479
59E:E:E193 E:E:F115 41.90092.33YesYes497
60E:E:F196 E:E:W197 40.904311.02YesYes499
61E:E:R194 E:E:Y131 41.14092.06NoYes098
62E:E:Y128 E:E:Y131 82.03651.99YesYes488
63E:E:E193 E:E:Y131 41.07463.37YesYes498
64E:E:W197 E:E:Y128 40.501213.5YesYes498
65E:E:S152 E:E:Y128 1003.82NoYes098
66E:E:L132 E:E:S152 1003NoNo089
67E:E:L132 E:E:L153 1009.69NoNo089
68S:S:Q724 S:S:Y728 11.19116.76NoYes097
69R:R:L721 S:S:Q724 11.00252.66NoNo099
70E:E:L153 R:R:F510 1002.44NoYes099
71R:R:F510 R:R:V603 1006.55YesYes1699
72E:E:K370 E:E:Y417 15.14444.78NoYes387
73E:E:E367 E:E:K370 14.98094.05NoNo378
74E:E:E367 E:E:W363 12.195415.27NoYes376
75R:R:V600 R:R:V603 1001.6NoYes099
76R:R:V506 R:R:V600 1004.81NoNo099
77R:R:P610 R:R:V506 1005.3NoNo099
78R:R:E609 R:R:P610 1003.14YesNo099
79R:R:E609 R:R:K502 1002.7YesNo899
80R:R:K502 R:R:L454 1005.64NoYes899
81R:R:L454 R:R:T498 1002.95YesNo099
82R:R:I458 R:R:T498 1003.04NoNo099
83R:R:I458 R:R:V495 1004.61NoYes098
84R:R:S462 R:R:V495 19.51483.23NoYes098
85R:R:V655 R:R:Y466 18.88445.05YesYes078
86R:R:C427 R:R:Y466 13.67594.03NoYes088
87R:R:C427 R:R:H652 13.39637.37NoYes089
88R:R:F648 R:R:H652 24.886713.58NoYes299
89R:R:F648 R:R:I420 24.30857.54NoNo098
90R:R:I420 R:R:L644 20.83715.71NoNo089
91R:R:L644 R:R:R417 20.25854.86NoYes099
92R:R:D641 R:R:R417 16.786513.1NoYes2699
93R:R:D641 R:R:S640 16.2082.94NoNo098
94R:R:S640 R:R:V410 15.62931.62NoNo086
95R:R:Q639 R:R:V410 15.05065.73NoNo096
96R:R:Q639 R:R:T564 13.89315.67NoNo099
97R:R:F570 R:R:T564 13.31442.59NoNo099
98R:R:F570 R:R:G562 12.15694.52NoNo097
99R:R:G562 R:R:Q561 11.57811.64NoYes075
100R:R:V495 R:R:Y496 94.787412.62YesYes089
101R:R:I659 R:R:S462 10.59593.1YesNo079
102R:R:T656 R:R:Y466 13.67596.24NoYes098
103R:R:H652 R:R:T656 13.39635.48YesNo099
104R:R:F492 R:R:Y496 82.34039.28YesYes299
105R:R:E586 R:R:F492 80.819311.66YesYes299
106R:R:E586 R:R:L489 78.82342.65YesNo097
107R:R:L489 R:R:T582 77.63225.9NoNo078
108R:R:F540 R:R:T582 77.08452.59YesNo298
109R:R:F540 S:S:W578 74.53914.01YesYes299
110S:S:W544 S:S:W578 73.29686.56YesYes299
111S:S:R485 S:S:W544 70.260510YesYes099
112S:S:D579 S:S:R485 67.42117.15NoYes099
113S:S:D579 S:S:I575 24.26192.8NoYes796
114S:S:D579 S:S:F632 43.06952.39NoYes799
115S:S:I575 S:S:R631 23.24362.51YesYes769
116S:S:F632 S:S:R631 23.24399.62YesYes799
117S:S:H628 S:S:R631 37.48074.51YesYes789
118S:S:E586 S:S:H628 40.40766.15NoYes798
119S:S:E586 S:S:R488 14.40138.14NoNo799
120S:S:L465 S:S:R488 14.15462.43NoNo099
121S:S:L465 S:S:V655 13.87218.94NoNo097
122S:S:A583 S:S:F632 18.8212.77NoYes089
123S:S:A583 S:S:H628 18.72845.85NoYes088
124S:S:D431 S:S:L459 10.18572.71YesNo069
125S:S:E586 S:S:F492 25.72465.83NoYes799
126S:S:F492 S:S:Y496 11.6110.32YesYes799
127S:S:V495 S:S:Y496 21.52346.31NoYes089
128S:S:G461 S:S:V495 20.95721.84NoNo098
129S:S:G461 S:S:T494 20.39123.64NoNo097
130S:S:T457 S:S:T494 18.69321.57NoNo067
131S:S:T457 S:S:T498 18.12721.57NoYes069
132S:S:H628 S:S:S624 15.54932.79YesNo089
133S:S:E620 S:S:S624 15.27817.19YesNo099
134S:S:E620 S:S:Y496 11.612123.57YesYes799
135S:S:F492 S:S:F589 10.47582.14YesNo098
136S:S:F589 S:S:W592 10.19285.01NoNo089
137S:S:L454 S:S:T498 13.02984.42YesYes1099
138E:E:H88 E:E:Y24 17.03193.27YesYes684
139B:B:R369 B:B:W387 12.259217.99YesYes198
140E:E:D294 E:E:P295 10.05164.83YesYes195
141B:B:K107 B:B:W387 11.15419.73YesYes198
142B:B:V354 B:B:Y319 10.17193.79NoYes056
143B:B:D332 B:B:R374 18.81595.96NoYes155
144B:B:V255 B:B:Y289 44.58857.57NoYes566
145B:B:C242 B:B:G257 44.07931.96NoNo077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7SHF
Class C
SubFamily Orphan
Type Orphan
SubType GPR158
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners B5; RGS7
PDB Resolution 3.4
Date 2021-12-01
D.O.I. doi.org/10.1126/science.abl4732
Net Summary
Imin 1.96
Number of Linked Nodes 1242
Number of Links 1560
Number of Hubs 270
Number of Links mediated by Hubs 968
Number of Communities 31
Number of Nodes involved in Communities 386
Number of Links involved in Communities 581
Path Summary
Number Of Nodes in MetaPath 146
Number Of Links MetaPath 145
Number of Shortest Paths 24803094
Length Of Smallest Path 3
Average Path Length 79.7405
Length of Longest Path 86
Minimum Path Strength 1.155
Average Path Strength 8.00298
Maximum Path Strength 20.48
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 69.1755
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 66.2059
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus   • regulation of cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • regulation of localization   • cellular localization   • transport   • modulation of chemical synaptic transmission   • positive regulation of neurotransmitter secretion   • positive regulation of biological process   • positive regulation of secretion by cell   • localization   • synaptic signaling   • regulation of secretion by cell   • secretion by cell   • positive regulation of secretion   • signal release   • establishment of localization in cell   • positive regulation of cellular process   • trans-synaptic signaling   • positive regulation of neurotransmitter transport   • neurotransmitter secretion   • regulation of transport   • secretion   • regulation of neurotransmitter transport   • export from cell   • cell-cell signaling   • positive regulation of synaptic transmission   • neurotransmitter transport   • establishment of localization   • regulation of secretion   • chemical synaptic transmission   • signal release from synapse   • regulation of trans-synaptic signaling   • positive regulation of transport   • regulation of neurotransmitter secretion   • anterograde trans-synaptic signaling   • positive regulation of signaling   • protein localization to cell periphery   • protein localization to plasma membrane   • macromolecule localization   • intracellular protein localization   • localization within membrane   • protein localization to membrane   • system process   • nervous system process   • cognition   • regulation of cellular component organization   • cellular component organization   • regulation of synapse organization   • cell junction organization   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of biological quality   • postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction
Gene OntologyCellular Component• postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction   • postsynaptic membrane   • asymmetric synapse   • plasma membrane region   • presynapse   • presynaptic membrane   • cell projection   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • nucleus   • intracellular membrane-bounded organelle   • protein binding   • binding   • G-protein gamma-subunit binding   • GTPase regulator activity   • enzyme regulator activity   • enzyme activator activity   • GTPase activator activity   • molecular function activator activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • protein-folding chaperone binding   • cellular response to stimulus   • response to light stimulus   • dark adaptation   • response to light intensity   • cellular response to absence of light   • response to stimulus   • cellular response to light intensity   • cellular response to radiation   • response to absence of light   • cellular response to environmental stimulus   • cellular response to light stimulus   • response to radiation   • response to abiotic stimulus   • cellular process   • cellular response to abiotic stimulus   • cellular response to nitrogen compound   • response to dopamine   • regulation of cellular process   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • G protein-coupled receptor signaling pathway   • regulation of localization   • regulation of calcium ion transport   • negative regulation of voltage-gated calcium channel activity   • negative regulation of ion transmembrane transporter activity   • negative regulation of calcium ion transmembrane transporter activity   • transport   • negative regulation of monoatomic ion transport   • monoatomic ion transmembrane transport   • negative regulation of biological process   • regulation of transmembrane transporter activity   • negative regulation of transport   • regulation of monoatomic ion transmembrane transport   • regulation of voltage-gated calcium channel activity   • negative regulation of transmembrane transport   • calcium ion transport   • metal ion transport   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • localization   • negative regulation of monoatomic ion transmembrane transport   • negative regulation of cellular process   • monoatomic ion transport   • negative regulation of cation transmembrane transport   • monoatomic cation transport   • regulation of metal ion transport   • regulation of transport   • regulation of monoatomic ion transport   • negative regulation of transporter activity   • negative regulation of molecular function   • establishment of localization   • negative regulation of calcium ion transport   • transmembrane transport   • regulation of molecular function   • regulation of transmembrane transport   • regulation of monoatomic cation transmembrane transport   • negative regulation of calcium ion transmembrane transport   • calcium ion transmembrane transport   • light adaption   • cell tip   • cell pole   • myelin sheath   • photoreceptor inner segment   • cytoplasm   • cytosol   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • somatodendritic compartment   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • rod photoreceptor outer segment   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • G-protein alpha-subunit binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • positive regulation of molecular function   • positive regulation of hydrolase activity   • regulation of catalytic activity   • regulation of hydrolase activity   • positive regulation of catalytic activity   • regulation of GTPase activity   • positive regulation of GTPase activity   • regulation of postsynaptic membrane potential   • regulation of biological quality   • regulation of membrane potential   • regulation of signaling   • negative regulation of signaling   • negative regulation of response to stimulus   • regulation of signal transduction   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • regulation of response to stimulus   • regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • intracellular signal transduction   • dendrite terminus   • glutamatergic synapse
SCOP2Domain Identifier• Regulator of G-protein signaling, RGS
SCOP2Family Identifier• Regulator of G-protein signaling, RGS
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtO14775
Sequence
>7SHF_Chain_B
ENETLASLK SEAESLKGK LEEERAKLH DVELHQVAE RVEALGQFV 
MKTRRTLKG HGNKVLCMD WCKDKRRIV SSSQDGKVI VWDSFTTNK 
EHAVTMPCT WVMACAYAP SGCAIACGG LDNKCSVYP LTFDKNENM 
AAKKKSVAM HTNYLSACS FTNSDMQIL TASGDGTCA LWDVESGQL 
LQSFHGHGA DVLCLDLAP SETGNTFVS GGCDKKAMV WDMRSGQCV 
QAFETHESD VNSVRYYPS GDAFASGSD DATCRLYDL RADREVAIY 
SKESIIFGA SSVDFSLSG RLLFAGYND YTINVWDVL KGSRVSILF 
GHENRVSTL RVSPDGTAF CSGSWDHTL RVWA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainE
ProteinRGP
UniProtP49802
Sequence
>7SHF_Chain_E
SPNMLVYRK MEDVIARMQ DEKNGIPIR TVKSFLSKI PSVFSGSDI 
VQWLIKNLT IEDPVEALH LGTLMAAHG YFFPISDHV LTLKDDGTF 
YRFQTPYFW PSNCWEPEN TDYAVYLCK RTMQNKARL ELADYEAES 
LARLQRAFA RKWEFIFMQ AEAQAKVDK KRDKIERKI LDSQERAFW 
DVHRPVPGC VNTTEVDIK KSSPPTEDE LQQQIKYWQ IQLDRHRLK 
MSKVADSLL SYTEQYLEY DPFLLPPDP SNPWLSDDT TFWELEASK 
EPSQQRVKR WGFGMDEAL KDPVGREQF LKFLESEFS SENLRFWLA 
VEDLKKRPI KEVPSRVQE IWQEFLAPG APSAINLDS KSYDKTTQN 
VKEPGRYTF EDAQEHIYK LMKSDSYPR FIRSSAYQE LLQA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T848
Sequence
>7SHF_Chain_R
SPCFVQEDK YLRLAIISF QALCMLLDF VSMLVVYHF RKAKSIRAS 
GLILLETIL FGSLLLYFP VVILYFEPS TFRCILLRW ARLLGFATV 
YGTVTLKLH RVLKVFLSR TAQRIPYMT GGRVMRMLA VILLVVFWF 
LIGWTSSVC QNLEKQISL IGQGKTSDH LIFNMCLID RWDYMTAVA 
EFLFLLWGV YLCYAVRTV PSAFHEPRY MAVAVHNEL IISAIFHTI 
RFVLASRLQ SDWMLMLYF AHTHLTVTV TIGLLLIPK FSHSSLDPE 
DIRDELKKL YAQLEIYKR KKMITNNP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ5T848
Sequence
>7SHF_Chain_S
SPCFVQEDK YLRLAIISF QALCMLLDF VSMLVVYHF RKAKSIRAS 
GLILLETIL FGSLLLYFP VVILYFEPS TFRCILLRW ARLLGFATV 
YGTVTLKLH RVLKVFLSR TAQRIPYMT GGRVMRMLA VILLVVFWF 
LIGWTSSVC QNLEKQISL IGQGKTSDH LIFNMCLID RWDYMTAVA 
EFLFLLWGV YLCYAVRTV PSAFHEPRY MAVAVHNEL IISAIFHTI 
RFVLASRLQ SDWMLMLYF AHTHLTVTV TIGLLLIPK FSHSEDIRD 
ELKKLYAQL EIYKR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EWLCOrphanOrphanGPR158Homo sapiens---3.522021-12-01doi.org/10.1038/s41467-021-27147-1
7EWPCOrphanOrphanGPR158Homo sapiens--B5; RGS74.32021-12-01doi.org/10.1038/s41467-021-27147-1
7EWRCOrphanOrphanGPR158Homo sapiens--B5; RGS74.72021-12-01doi.org/10.1038/s41467-021-27147-1
7SHECOrphanOrphanGPR158Homo sapiens---3.42021-12-01doi.org/10.1126/science.abl4732
7SHFCOrphanOrphanGPR158Homo sapiens--B5; RGS73.42021-12-01doi.org/10.1126/science.abl4732




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