Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:L64 7.758588
2B:B:K65 7.298586
3B:B:L68 6.912587
4B:B:E69 4.9925484
5B:B:E71 5.6425484
6B:B:E79 7.563336194
7B:B:L80 4.2754195
8B:B:L90 6.4054204
9B:B:F93 5.194503
10B:B:H104 6.368509
11B:B:W113 6.7025468
12B:B:W132 11.3865399
13B:B:D133 7.9675468
14B:B:F135 4.905664
15B:B:M145 6.41254408
16B:B:W149 15.978549
17B:B:V150 5.99754409
18B:B:Y155 5.813336277
19B:B:K180 8.7145343
20B:B:N183 5.01754344
21B:B:K188 9.65754414
22B:B:H194 7.3375449
23B:B:Y197 6.928548
24B:B:S202 4.555446
25B:B:T204 4.455445
26B:B:S206 4.79254435
27B:B:Q209 9.39405
28B:B:T212 6.005449
29B:B:S214 5.6525449
30B:B:G215 4.54448
31B:B:D216 10.355449
32B:B:T218 8.9175447
33B:B:W222 7.954549
34B:B:S226 5.6425406
35B:B:H236 7.234549
36B:B:S256 3.575449
37B:B:G257 2.3407
38B:B:M264 6.4575407
39B:B:W266 11.676549
40B:B:T279 5.9954156
41B:B:H280 7.914159
42B:B:D283 9.00754239
43B:B:R288 6.844564
44B:B:Y289 4.4545286
45B:B:Y290 5.0285456
46B:B:D302 7.4154159
47B:B:R306 6.517158
48B:B:D309 4.8125409
49B:B:R314 9.65254197
50B:B:E315 9.564157
51B:B:Y319 3.5075406
52B:B:I324 5.576676104
53B:B:F326 4.215406
54B:B:R338 6.27209
55B:B:L339 5.6725135
56B:B:F341 7.4245136
57B:B:Y344 9.6245108
58B:B:N345 7.4985237
59B:B:D346 5.6254108
60B:B:Y347 6.79254104
61B:B:T348 5.74254105
62B:B:N350 9.191676106
63B:B:W352 5.1185109
64B:B:L355 4.1325207
65B:B:K356 2.8825406
66B:B:R359 11.28254106
67B:B:I362 9.2345104
68B:B:F364 6.87254104
69B:B:R374 6.32465
70B:B:P377 4.795462
71B:B:D378 8.66167668
72B:B:F382 9.90254135
73B:B:W387 14.9975408
74B:B:D388 7.794469
75B:B:W394 6.575138
76E:E:P19 4.124238
77E:E:M27 8.0254298
78E:E:M34 5.7275408
79E:E:I41 5.688528
80E:E:P54 4.755408
81E:E:F57 6.666525
82E:E:S58 3.3125407
83E:E:W65 7.526506
84E:E:E77 6.7725109
85E:E:M85 3.6585296
86E:E:H88 6.234298
87E:E:Y90 10.04754299
88E:E:F92 5.85409
89E:E:H97 6.39599
90E:E:V98 3.185407
91E:E:Y108 6.12408
92E:E:R109 6.688529
93E:E:F110 8.72429
94E:E:Q111 4.122529
95E:E:T112 4.77125828
96E:E:Y114 7.81333627
97E:E:F115 12.956527
98E:E:Y128 5.608598
99E:E:R135 2.7625499
100E:E:M137 3.724519
101E:E:Q138 10.1975499
102E:E:R142 3.675409
103E:E:Y148 9.364598
104E:E:E149 10.094599
105E:E:F160 4.314508
106E:E:W164 6.7275409
107E:E:F166 10.9167629
108E:E:M169 8.7775428
109E:E:E172 4.04254519
110E:E:R181 10.06254548
111E:E:R186 11.5125499
112E:E:Q192 5.99529
113E:E:R194 7.272599
114E:E:F196 11.126529
115E:E:W197 5.398509
116E:E:K215 5.238549
117E:E:Q261 6.83584
118E:E:W265 8.61167685
119E:E:Q266 4.5725484
120E:E:Q268 6.51585
121E:E:R273 8.932584
122E:E:M276 6.974194
123E:E:L291 6.35254201
124E:E:D294 7.6175409
125E:E:F296 4.41754134
126E:E:L297 5.2645204
127E:E:W306 4.48286768
128E:E:W314 9.4525467
129E:E:P322 5.3265245
130E:E:R326 7.135249
131E:E:W330 7.0345249
132E:E:F332 6.6125408
133E:E:M334 10.36405
134E:E:D340 9.3445249
135E:E:V342 5.4985244
136E:E:W363 9.2954266
137E:E:R380 8.125456
138E:E:V381 4.594558
139E:E:Q382 3.58454
140E:E:I384 5.9459
141E:E:W385 9.88143756
142E:E:E387 9.44459
143E:E:L389 8.32333659
144E:E:I397 6.3075458
145E:E:L399 6.282557
146E:E:Y404 6.56167654
147E:E:K406 9.29403
148E:E:T407 5.305659
149E:E:P414 6.184556
150E:E:T418 6.9725455
151E:E:F419 8.0175455
152E:E:I426 7.6054268
153E:E:M430 6.0654269
154E:E:Y435 8.8385259
155E:E:Y444 7.70754259
156R:R:Q72 11.20754124
157R:R:L86 10.105438
158R:R:L94 6.894539
159R:R:K95 6.7525432
160R:R:N98 6.315438
161R:R:G107 2.9225435
162R:R:P113 2.714555
163R:R:F135 4.9578
164R:R:L136 3.8525409
165R:R:M139 3.65407
166R:R:Q148 7.27576
167R:R:N149 3.75407
168R:R:D152 5.94167676
169R:R:D153 6.664579
170R:R:W156 16.364579
171R:R:Y157 5.578579
172R:R:W162 9.564307
173R:R:L165 6.8154306
174R:R:E168 7.045408
175R:R:I176 4.9325477
176R:R:F178 7.158576
177R:R:T180 4.572574
178R:R:F191 10.9425318
179R:R:L192 4.77479
180R:R:I201 7.50754309
181R:R:F263 13.4575436
182R:R:K264 4.5975404
183R:R:S266 4.4575438
184R:R:P267 5.275435
185R:R:Y269 5.18667635
186R:R:E271 10.1375438
187R:R:Y277 15.142538
188R:R:P279 7.174539
189R:R:W281 27.735439
190R:R:L282 8.9875437
191R:R:T284 3.7125438
192R:R:I289 5.938578
193R:R:I308 4.9625436
194R:R:L310 5.32538
195R:R:Q317 4.98754129
196R:R:C318 6.09254129
197R:R:W323 12.826539
198R:R:H328 6.3745129
199R:R:N334 5.9654327
200R:R:C337 5.01754129
201R:R:P339 5.194128
202R:R:F345 7.438539
203R:R:Y350 4.4756129
204R:R:F358 5.67254357
205R:R:Y359 3.615409
206R:R:C392 4.5145329
207R:R:F409 4.6625363
208R:R:E412 11.46754337
209R:R:R417 6.766339
210R:R:Q424 10.6354169
211R:R:M428 4.53754167
212R:R:S446 3.665408
213R:R:Y466 9.5265168
214R:R:F467 2.88254167
215R:R:R485 8.4375409
216R:R:R488 4.1685119
217R:R:Y496 8.7845119
218R:R:K502 3.585409
219R:R:F510 4.7654529
220R:R:W544 8.1675409
221R:R:N551 3.36407
222R:R:Q561 2.985405
223R:R:W578 6.642509
224R:R:E586 8.7654119
225R:R:L590 2.20254119
226R:R:P604 3.4085529
227R:R:E620 8.0625119
228R:R:I623 5.3325405
229R:R:F627 6.965119
230R:R:H628 5.7345118
231R:R:R631 6.39254119
232R:R:Q639 8.65754339
233R:R:Y647 7.29754115
234R:R:H650 6.3685119
235R:R:H652 9.066169
236R:R:W704 7.91375827
237R:R:D713 8.16429
238R:R:K720 13.3325429
239R:R:L721 8.2529
240R:R:Y722 7.116529
241R:R:Q724 11.8825429
242R:R:Y728 11.4975427
243R:R:K731 8.0325429
244R:R:T735 6.0825427
245R:R:K743 6.965409
246R:R:L750 7.56528
247R:R:I758 4.7975428
248R:R:I761 7.1425428
249S:S:P79 8.5575415
250S:S:Y85 13.8217618
251S:S:Q93 8.688514
252S:S:Y103 7.376515
253S:S:L105 9.092515
254S:S:P109 5.65414
255S:S:L115 5.78254185
256S:S:L126 2.734184
257S:S:L129 5.624186
258S:S:T130 3.95254184
259S:S:F135 6.05478
260S:S:M139 6.935407
261S:S:Q148 4.07406
262S:S:D152 9.842576
263S:S:D153 5.99479
264S:S:W156 13.9967679
265S:S:Y157 7.25409
266S:S:W162 6.476177
267S:S:E168 6.3225408
268S:S:T177 7.244518
269S:S:L192 5.5954179
270S:S:Q193 6.2175408
271S:S:I201 7.8765179
272S:S:L203 6.8856179
273S:S:P211 5.14333614
274S:S:F263 5.5665186
275S:S:K264 6.23667614
276S:S:P268 9.675419
277S:S:L270 10.865419
278S:S:C272 3.69419
279S:S:Y277 9.61889918
280S:S:W281 18.044519
281S:S:L282 3.2875417
282S:S:S286 6.9875419
283S:S:I289 5.0125418
284S:S:Y290 6.49408
285S:S:R301 7.27571718
286S:S:V303 4.412519
287S:S:K305 7.85167618
288S:S:D307 5.9275419
289S:S:L310 9.81418
290S:S:Q311 12.435419
291S:S:C318 5.664149
292S:S:G322 3.1154375
293S:S:W323 6.826519
294S:S:C337 3.9756149
295S:S:F345 6.652519
296S:S:Y350 7.815149
297S:S:I420 3.86408
298S:S:E456 3.92254659
299S:S:I458 3.0375409
300S:S:G461 1.874389
301S:S:L464 2.8054388
302S:S:Y466 7.828577218
303S:S:R488 2.6654229
304S:S:Y496 5.7965229
305S:S:T498 3.805409
306S:S:T500 3.0975407
307S:S:F540 3.75754629
308S:S:W544 6.0185629
309S:S:I559 3.545408
310S:S:K563 3.0925404
311S:S:I569 2.7475405
312S:S:F570 3.875649
313S:S:W578 5.7485629
314S:S:E586 8.26754229
315S:S:L590 3.0054229
316S:S:V603 4.7775409
317S:S:E609 3.0485669
318S:S:E620 8.21754229
319S:S:F627 16.965409
320S:S:H628 6.4925228
321S:S:M643 3.795408
322S:S:Y647 7.99405
323S:S:F648 6.78254219
324S:S:H652 9.436676219
325S:S:T654 4.7875409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L355 B:B:R338 80.04696.07YesYes2079
2B:B:R338 E:E:L297 53.28913.64YesYes2094
3B:B:F93 E:E:L297 26.71344.87YesYes034
4B:B:F93 B:B:M95 26.385112.44YesNo035
5B:B:A395 B:B:M95 26.34344.83NoNo085
6B:B:A395 E:E:F296 53.21052.77NoYes084
7E:E:D294 E:E:F296 52.96175.97YesYes094
8E:E:D294 E:E:L297 26.51519.5YesYes094
9B:B:S336 E:E:D294 26.651811.78NoYes099
10B:B:R338 B:B:S336 26.55533.95YesNo099
11B:B:A395 B:B:R98 79.41935.53NoNo087
12B:B:R98 E:E:L307 79.28889.72NoNo074
13E:E:N304 E:E:W306 45.22314.52NoYes098
14E:E:L307 E:E:N304 79.02794.12NoNo049
15B:B:F296 B:B:V287 14.23566.55NoNo068
16B:B:C242 B:B:V287 14.0215.12NoNo078
17B:B:C242 B:B:G257 13.97811.96NoYes077
18B:B:G257 B:B:H236 13.85043.18YesYes079
19B:B:W352 B:B:Y319 99.42167.72YesYes096
20B:B:V354 B:B:Y319 83.88392.52NoYes056
21B:B:L355 B:B:V354 83.85315.96YesNo075
22E:E:N304 E:E:P305 33.67694.89NoNo099
23E:E:P305 E:E:W314 33.411127.02NoYes697
24B:B:D378 E:E:W314 33.2853.35YesYes687
25B:B:T380 E:E:W306 33.64387.28NoYes658
26B:B:D378 B:B:T380 33.511613.01YesNo685
27B:B:D378 B:B:K117 65.388613.83YesNo085
28B:B:K117 E:E:E317 65.1234.05NoNo056
29B:B:P247 B:B:Y289 14.63725.56NoYes2846
30B:B:G293 B:B:P247 14.72584.06NoNo084
31B:B:L340 B:B:Y319 15.51422.34NoYes076
32B:B:F333 B:B:L340 15.4756.09NoNo087
33B:B:F333 B:B:Y290 15.34245.16NoYes4586
34B:B:D294 B:B:G293 14.76863.35NoNo038
35B:B:D294 B:B:S292 14.8388.83NoNo035
36B:B:S292 B:B:Y290 15.22522.54NoYes056
37B:B:N350 B:B:W352 98.47444.52YesYes1069
38B:B:N350 B:B:R359 49.273110.85YesYes1066
39B:B:I362 B:B:N350 49.32767.08YesYes1046
40B:B:R359 E:E:E77 49.341112.79YesYes1069
41B:B:I362 E:E:E77 49.32058.2YesYes1049
42E:E:E77 E:E:I72 1005.47YesNo095
43E:E:I72 E:E:L70 99.91892.85NoNo057
44E:E:L70 E:E:W65 99.93252.28NoYes076
45E:E:I41 E:E:W65 99.83337.05YesYes086
46E:E:F110 E:E:I41 76.70735.02YesYes298
47E:E:F110 R:R:W704 76.803815.03YesYes297
48E:E:F57 E:E:I41 23.16738.79YesYes258
49E:E:F57 E:E:Y108 23.387710.32YesYes058
50E:E:P93 E:E:Y108 23.32972.78NoYes098
51E:E:T112 R:R:W704 52.2454.85YesYes287
52E:E:Q111 E:E:T112 23.99232.83YesYes298
53E:E:Q192 R:R:W704 23.98574.38YesYes297
54E:E:Q111 E:E:Q192 24.01552.56YesYes299
55E:E:D96 E:E:P93 23.19813.22NoNo099
56E:E:D96 E:E:V98 23.16532.92NoYes097
57E:E:V203 E:E:V98 23.00544.81NoYes097
58E:E:V203 E:E:Y148 22.96.31NoYes998
59E:E:E149 E:E:Y148 22.772823.57YesYes998
60E:E:F196 E:E:Q111 48.01153.51YesYes299
61E:E:F196 E:E:W197 71.96018.02YesYes099
62E:E:W197 E:E:Y128 67.99468.68YesYes098
63E:E:E149 E:E:Y128 67.44493.37YesYes998
64E:E:F115 E:E:T112 24.4063.89YesYes278
65E:E:F115 E:E:F196 24.322536.44YesYes279
66E:E:E149 E:E:L145 90.251610.6YesNo099
67E:E:A150 E:E:L145 90.10781.58NoNo089
68E:E:A150 R:R:P604 89.5283.74NoYes089
69E:E:E317 E:E:R326 64.857415.12NoYes069
70E:E:P322 E:E:R326 17.56864.32YesYes2459
71E:E:P322 E:E:V327 16.23073.53YesNo059
72E:E:D340 E:E:R326 43.30978.34YesYes2499
73E:E:L448 E:E:V327 15.69142.98NoNo089
74E:E:Q423 E:E:W363 15.577410.95NoYes096
75E:E:M430 E:E:W363 25.09029.31YesYes2696
76E:E:M334 E:E:Y435 12.258316.76YesYes059
77E:E:L448 E:E:Y444 15.15865.86NoYes2589
78E:E:M334 E:E:S434 16.78223.07YesNo059
79E:E:L338 E:E:W363 40.95123.42NoYes086
80E:E:L338 E:E:R344 41.47576.07NoNo086
81E:E:D340 E:E:P341 42.00348.05YesNo095
82E:E:F347 E:E:S434 12.78467.93NoNo099
83E:E:I426 E:E:M430 18.65145.83YesYes2689
84E:E:Q423 E:E:V366 17.48414.33NoNo098
85E:E:F362 E:E:V366 17.17327.87NoNo098
86E:E:F362 E:E:I426 14.677.54NoYes098
87E:E:F362 E:E:I397 31.19517.54NoYes098
88E:E:I397 E:E:L389 19.65268.56YesYes589
89E:E:F419 E:E:L389 11.5762.44YesYes559
90R:R:P604 R:R:V603 88.65113.53YesNo5299
91R:R:S605 R:R:V603 88.5354.85NoNo099
92R:R:A606 R:R:S605 88.3911.71NoNo099
93R:R:A606 R:R:F607 88.24716.93NoNo098
94R:R:F607 R:R:S446 88.10315.28NoYes088
95R:R:K666 R:R:S446 86.95086.12NoYes098
96R:R:K666 R:R:S450 86.50944.59NoNo5999
97R:R:K502 R:R:S450 86.37431.53YesNo099
98R:R:K502 R:R:M613 85.22055.76YesNo097
99R:R:L662 R:R:M613 81.60857.07NoNo087
100R:R:L661 R:R:L662 81.46381.38NoNo088
101R:R:L661 R:R:V657 81.17442.98NoNo087
102R:R:N619 R:R:V657 80.74025.91NoNo097
103R:R:I623 R:R:N619 80.59547.08YesNo059
104R:R:H650 R:R:I623 70.9243.98YesYes095
105R:R:F627 R:R:H650 13.604914.71YesYes1199
106R:R:F627 R:R:R631 11.07662.14YesYes1199
107R:R:F632 R:R:R631 10.976.41NoYes099
108R:R:H650 R:R:R488 55.60227.9YesYes1199
109R:R:E586 R:R:R488 52.36755.82YesYes1199
110R:R:E586 R:R:T582 52.41064.23YesNo098
111R:R:F540 R:R:T582 52.26362.59NoNo098
112R:R:F540 S:S:W539 52.1174.01NoNo099
113S:S:F540 S:S:W539 51.8246.01YesNo099
114S:S:F540 S:S:W544 42.54392YesYes6299
115S:S:R485 S:S:W544 41.96078NoYes099
116S:S:D579 S:S:R485 41.663716.68NoNo099
117S:S:D579 S:S:F632 17.88392.39NoNo099
118S:S:I575 S:S:Y580 13.26772.42NoNo068
119S:S:I575 S:S:L574 12.96654.28NoNo067
120S:S:K563 S:S:L574 12.66524.23YesNo047
121S:S:K563 S:S:Q561 10.55631.36YesNo045
122S:S:F632 S:S:R631 11.06656.41NoNo099
123S:S:R631 S:S:Y647 10.916711.32NoYes095
124S:S:D579 S:S:T582 23.64057.23NoNo098
125S:S:L489 S:S:T582 23.49094.42NoNo078
126S:S:L489 S:S:R488 23.34152.43NoYes079
127S:S:E586 S:S:R488 11.74762.33YesYes2299
128S:S:E586 S:S:S624 10.99454.31YesNo2299
129S:S:E620 S:S:S624 21.76325.75YesNo2299
130S:S:E620 S:S:Y496 17.231814.59YesYes2299
131S:S:F589 S:S:Y496 10.28712.06NoYes089
132S:S:H628 S:S:R488 11.2952.26YesYes2289
133S:S:H628 S:S:S624 11.07032.79YesNo2289
134E:E:P341 E:E:R344 41.73852.88NoNo056
135B:B:F296 B:B:Y289 14.10825.16NoYes2866
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EWP
Class C
SubFamily Orphan
Type Orphan
SubType GPR158
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners B5; RGS7
PDB Resolution 4.3
Date 2021-12-01
D.O.I. 10.1038/s41467-021-27147-1
Net Summary
Imin 1.84
Number of Linked Nodes 1695
Number of Links 2061
Number of Hubs 325
Number of Links mediated by Hubs 1149
Number of Communities 67
Number of Nodes involved in Communities 533
Number of Links involved in Communities 760
Path Summary
Number Of Nodes in MetaPath 136
Number Of Links MetaPath 135
Number of Shortest Paths 14320992
Length Of Smallest Path 3
Average Path Length 58.4529
Length of Longest Path 100
Minimum Path Strength 1.19
Average Path Strength 6.96123
Maximum Path Strength 41.255
Minimum Path Correlation 0.73
Average Path Correlation 0.999823
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 12.1212
Average % Of Corr. Nodes 49.1465
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.8366
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus   • regulation of cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cell communication   • regulation of localization   • cellular localization   • transport   • modulation of chemical synaptic transmission   • positive regulation of neurotransmitter secretion   • positive regulation of biological process   • positive regulation of secretion by cell   • localization   • synaptic signaling   • regulation of secretion by cell   • secretion by cell   • positive regulation of secretion   • signal release   • establishment of localization in cell   • positive regulation of cellular process   • trans-synaptic signaling   • positive regulation of neurotransmitter transport   • neurotransmitter secretion   • regulation of transport   • secretion   • regulation of neurotransmitter transport   • export from cell   • cell-cell signaling   • positive regulation of synaptic transmission   • neurotransmitter transport   • establishment of localization   • regulation of secretion   • chemical synaptic transmission   • signal release from synapse   • regulation of trans-synaptic signaling   • positive regulation of transport   • regulation of neurotransmitter secretion   • anterograde trans-synaptic signaling   • positive regulation of signaling   • protein localization   • protein localization to cell periphery   • protein localization to plasma membrane   • cellular macromolecule localization   • macromolecule localization   • localization within membrane   • protein localization to membrane   • system process   • nervous system process   • cognition   • regulation of cellular component organization   • cellular component organization   • regulation of synapse organization   • cell junction organization   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of biological quality   • postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction
Gene OntologyCellular Component• postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction   • postsynaptic membrane   • asymmetric synapse   • plasma membrane region   • presynapse   • presynaptic membrane   • cell projection   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • nucleus   • intracellular membrane-bounded organelle   • pyrophosphatase activity   • enzyme regulator activity   • GTPase activity   • molecular function activator activity   • nucleoside-triphosphatase regulator activity   • hydrolase activity   • GTPase regulator activity   • enzyme activator activity   • ribonucleoside triphosphate phosphatase activity   • GTPase activator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • protein binding   • binding   • G-protein beta-subunit binding   • G-protein alpha-subunit binding   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of hydrolase activity   • regulation of catalytic activity   • regulation of hydrolase activity   • biological regulation   • positive regulation of catalytic activity   • regulation of GTPase activity   • positive regulation of GTPase activity   • response to stimulus   • response to alcohol   • response to chemical   • response to oxygen-containing compound   • response to ethanol   • response to amine   • response to nitrogen compound   • response to amphetamine   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell communication   • regulation of signaling   • negative regulation of signaling   • negative regulation of response to stimulus   • negative regulation of biological process   • regulation of signal transduction   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • regulation of response to stimulus   • negative regulation of cellular process   • regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • intracellular signal transduction   • regulation of localization   • positive regulation of cation transmembrane transport   • regulation of potassium ion transport   • transport   • monoatomic ion transmembrane transport   • positive regulation of biological process   • potassium ion transmembrane transport   • regulation of monoatomic ion transmembrane transport   • metal ion transport   • monoatomic cation transmembrane transport   • localization   • positive regulation of monoatomic ion transport   • positive regulation of transmembrane transport   • monoatomic ion transport   • positive regulation of monoatomic ion transmembrane transport   • monoatomic cation transport   • regulation of metal ion transport   • positive regulation of cellular process   • regulation of transport   • regulation of monoatomic ion transport   • inorganic ion transmembrane transport   • regulation of potassium ion transmembrane transport   • establishment of localization   • inorganic cation transmembrane transport   • transmembrane transport   • positive regulation of potassium ion transport   • regulation of transmembrane transport   • positive regulation of transport   • positive regulation of potassium ion transmembrane transport   • regulation of monoatomic cation transmembrane transport   • potassium ion transport   • organelle envelope   • nuclear envelope   • endomembrane system   • cytoplasm   • cytosol   • protein-containing complex   • neuron projection   • plasma membrane bounded cell projection   • G-protein gamma-subunit binding   • protein-folding chaperone binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • response to light stimulus   • dark adaptation   • response to light intensity   • cellular response to absence of light   • cellular response to light intensity   • cellular response to radiation   • response to absence of light   • cellular response to environmental stimulus   • cellular response to light stimulus   • response to radiation   • response to abiotic stimulus   • cellular response to abiotic stimulus   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • regulation of calcium ion transmembrane transporter activity   • regulation of calcium ion transport   • negative regulation of voltage-gated calcium channel activity   • negative regulation of ion transmembrane transporter activity   • negative regulation of calcium ion transmembrane transporter activity   • negative regulation of transport   • regulation of voltage-gated calcium channel activity   • calcium ion transport   • negative regulation of cation transmembrane transport   • regulation of cation channel activity   • negative regulation of calcium ion transmembrane transport   • negative regulation of cation channel activity   • negative regulation of monoatomic ion transport   • regulation of transmembrane transporter activity   • negative regulation of transmembrane transport   • regulation of transporter activity   • regulation of calcium ion transmembrane transport   • negative regulation of monoatomic ion transmembrane transport   • regulation of monoatomic ion transmembrane transporter activity   • negative regulation of transporter activity   • negative regulation of molecular function   • negative regulation of calcium ion transport   • calcium ion transmembrane transport   • light adaption   • cell tip   • cell pole   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • somatodendritic compartment   • dendrite   • dendritic tree   • GTPase activator complex   • enzyme activator complex
SCOP2Domain Identifier• Regulator of G-protein signaling, RGS   • WD40 repeat-like
SCOP2Family Identifier• Regulator of G-protein signaling, RGS   • WD40 repeat-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtO14775
Sequence
>7EWP_Chain_B
LKSEAESLK GKLEEERAK LHDVELHQV AERVEALGQ FVMKTRRTL 
KGHGNKVLC MDWCKDKRR IVSSSQDGK VIVWDSFTT NKEHAVTMP 
CTWVMACAY APSGCAIAC GGLDNKCSV YPLTFDKNE NMAAKKKSV 
AMHTNYLSA CSFTNSDMQ ILTASGDGT CALWDVESG QLLQSFHGH 
GADVLCLDL APSETGNTF VSGGCDKKA MVWDMRSGQ CVQAFETHE 
SDINSVRYY PSGDAFASG SDDATCRLY DLRADREVA IYSKESIIF 
GASSVDFSL SGRLLFAGY NDYTINVWD VLKGSRVSI LFGHENRVS 
TLRVSPDGT AFCSGSWDH TLRVWA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainE
ProteinRGP
UniProtP49802
Sequence
>7EWP_Chain_E
SPNMLVYRK MEDVIARMQ DEKNGIPIR TVKSFLSKI PSVFSGSDI 
VQWLIKNLT IEDPVEALH LGTLMAAHG YFFPISDHV LTLKDDGTF 
YRFQTPYFW PSNCWEPEN TDYAVYLCK RTMQNKARL ELADYEAES 
LARLQRAFA RKWEFIFMQ AEAQAKVDK KRDKIERKI LDSQERAFW 
DVHRPVPGC VNTTEVDIK KSSDELQQQ IKYWQIQLD RHRLKMSKV 
ADSLLSYTE QYLEYDPFL LPPDPSNPW LSDDTTFWE LEASKEPSQ 
QRVKRWGFG MDEALKDPV GREQFLKFL ESEFSSENL RFWLAVEDL 
KKRPIKEVP SRVQEIWQE FLAPGAPSA INLDSKSYD KTTQNVKEP 
GRYTFEDAQ EHIYKLMKS DSYPRFIRS SAYQELLQA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5T848
Sequence
>7EWP_Chain_R
LAQKLAEEV PMDVASYLY TGDSHQLKR ANCSGRYEL AGLPGKWPA 
LASAHPSLH RALDTLTHA TNFLNVMLQ SNKSREQNL QDDLDWYQA 
LVWSLLEGE PSISRAAIT FSTQVFLQA TREESRILL QDPHLANAT 
LETSHFKWS PPYLECENG SYKPGWLVT LSSAIYGLL VPEFRGVMK 
VDINLQKVD IDQCSSDGW FSGTHKCHL NNSECMPIK GLGFVLGAY 
ECICKAGFY HPAYVCLPC REGCPFCAD DSPCFVQED KYLRLAIIS 
FQALCMLLD FVSMLVVYH FRKAKSIRA SGLILLETI LFGSLLLYF 
PVVILYFEP STFRCILLR WARLLGFAT VYGTVTLKL HRVLKVFLS 
RTAQRIPYM TGGRVMRML AVILLVVFW FLIGWTSSV CQNLEKQIS 
LIGQGKTSD HLIFNMCLI DRWDYMTAV AEFLFLLWG VYLCYAVRT 
VPSAFHEPR YMAVAVHNE LIISAIFHT IRFVLASRL QSDWMLMLY 
FAHTHLTVT VTIGLLLIP KFSAWSEHS LDPEDIRDE LKKLYAQLE 
IYKRKKMIT NNPHLQKKR CSKKGLGRS IMRRITEIP E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ5T848
Sequence
>7EWP_Chain_S
AQKLAEEVP MDVASYLYT GDSHQLKRA NCSGRYELA GLPGKWPAL 
ASAHPSLHR ALDTLTHAT NFLNVMLQS NKSREQNLQ DDLDWYQAL 
VWSLLEGEP SISRAAITF STQVFLQAT REESRILLQ DLSSSAPHL 
ANATLETHF KWSPPYLEC ENGSYKPGW LVTLSSAIY GLLVPEFRG 
VMKVDINLQ KVDIDQCSS DGWFSGTHK CHLNNSECM PIKGLGFVL 
GAYECICKA GFYHYVCLP CREGCPFCA DDSPCFVQE DKYLRLAII 
SFQALCMLL DFVSMLVVY HFRKAKSIR ASGLILLET ILFGSLLLY 
FPVVILYFE PSTFRCILL RWARLLGFA TVYGTVTLK LHRVLKVFL 
RVMRMLAVI LLVVFWFLI GWTSSVCQN LEKQISLIG QGKTSDHLI 
FNMCLIDRW DYMTAVAEF LFLLWGVYL CYAVRTVPS AFHEPRYMA 
VAVHNELII SAIFHTIRF VLASRLQSD WMLMLYFAH THLTVTVTI 
GLLLIPKFS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SHECOrphanOrphanGPR158Homo sapiens-PI; PE-3.42021-12-0110.1126/science.abl4732
7EWLCOrphanOrphanGPR158Homo sapiens---3.522021-12-0110.1038/s41467-021-27147-1
7SHFCOrphanOrphanGPR158Homo sapiens-PI; PEB5; RGS73.42021-12-0110.1126/science.abl4732
7EWRCOrphanOrphanGPR158Homo sapiens--B5; RGS74.72021-12-0110.1038/s41467-021-27147-1
7EWPCOrphanOrphanGPR158Homo sapiens--B5; RGS74.32021-12-0110.1038/s41467-021-27147-1




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