Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Q72 10.844144
2R:R:V82 7.7417
3R:R:L86 12.6775418
4R:R:Y87 9.958516
5R:R:L94 9.7625419
6R:R:Y103 8.225615
7R:R:G107 3.35415
8R:R:K111 8.2975413
9R:R:L115 5.13754285
10R:R:F135 4.9548
11R:R:M139 4.76547
12R:R:Q148 11.87446
13R:R:D152 5.096546
14R:R:D153 6.885649
15R:R:W156 14.0083649
16R:R:Y157 6.424549
17R:R:W162 104137
18R:R:L165 4.125136
19R:R:E168 6.56754138
20R:R:R173 6.94407
21R:R:I176 6.878547
22R:R:F178 9.296546
23R:R:I201 7.0245139
24R:R:F263 18.7185286
25R:R:W265 13.635287
26R:R:S266 4.926518
27R:R:P267 5.362515
28R:R:Y269 13.105615
29R:R:L270 16.27419
30R:R:S276 3.61414
31R:R:Y277 13.8533618
32R:R:P279 8.0575419
33R:R:G280 2.8075413
34R:R:W281 23.468519
35R:R:V283 4.3575406
36R:R:T284 7.9975418
37R:R:L285 3.78754289
38R:R:I289 7.94548
39R:R:F300 15.634458
40R:R:V303 4.8125409
41R:R:D307 11.4925419
42R:R:L310 6.5075418
43R:R:Q317 4.34754149
44R:R:C318 6.09254149
45R:R:S319 2.87417
46R:R:W323 11.0417619
47R:R:H328 4.09254149
48R:R:N334 5.9654307
49R:R:C337 5.01754149
50R:R:P339 5.194148
51R:R:F345 7.146519
52R:R:Y350 4.4756149
53R:R:F358 10.5754467
54R:R:V391 2.19403
55R:R:C392 4.5145309
56R:R:F409 4.6625373
57R:R:E412 11.46754317
58R:R:R417 6.766319
59R:R:Q424 10.6354169
60R:R:M428 4.53754167
61R:R:S446 3.665408
62R:R:Y466 9.5265168
63R:R:F467 2.88254167
64R:R:R485 8.4375409
65R:R:R488 4.1685119
66R:R:Y496 8.7845119
67R:R:K502 3.585409
68R:R:F510 4.7654509
69R:R:M521 6.21754498
70R:R:W544 8.1675409
71R:R:N551 3.36407
72R:R:Q561 2.985405
73R:R:W578 6.642509
74R:R:E586 8.7654119
75R:R:L590 2.20254119
76R:R:P604 3.4085509
77R:R:E620 8.0625119
78R:R:I623 5.3325405
79R:R:F627 6.965119
80R:R:H628 5.7345118
81R:R:R631 6.39254119
82R:R:Q639 8.65754319
83R:R:Y647 7.29754115
84R:R:H650 6.3685119
85R:R:H652 9.066169
86R:R:L709 6.592559
87R:R:E712 8.79167657
88R:R:D713 7.598559
89R:R:D716 7.13657
90R:R:K719 5.592559
91R:R:K720 10.352559
92R:R:K731 13.7085329
93R:R:K743 3.714329
94R:R:K747 16.36254329
95R:R:I754 6.57607
96R:R:R757 9.945459
97S:S:V82 9.162527
98S:S:S84 5.4875426
99S:S:Y85 16.0562828
100S:S:Q93 10.1237824
101S:S:Y103 16.515625
102S:S:L105 10.895405
103S:S:P109 5.3165334
104S:S:G110 2.97754336
105S:S:W112 2.83404
106S:S:P113 5.8825335
107S:S:L129 3.2254566
108S:S:F135 6.05448
109S:S:M139 6.935407
110S:S:Q148 4.8875446
111S:S:D152 5.42333646
112S:S:D153 6.538549
113S:S:W156 14.3683649
114S:S:Y157 5.376509
115S:S:W162 8.225297
116S:S:E166 5.20754298
117S:S:E168 6.435408
118S:S:I171 8.51508
119S:S:R173 7.354527
120S:S:F191 11.764578
121S:S:I201 7.45254299
122S:S:P211 4.4085574
123S:S:H212 9.696523
124S:S:N215 7.1075427
125S:S:K264 11.0075424
126S:S:W265 8.25254227
127S:S:S266 6.535428
128S:S:P268 9.99429
129S:S:Y269 8.748525
130S:S:L270 18.6075429
131S:S:C272 3.0175429
132S:S:Y277 10.0411928
133S:S:W281 21.05629
134S:S:L282 4.6125427
135S:S:T284 9.3075428
136S:S:I289 5.84238
137S:S:R301 13.2156238
138S:S:V303 5.9725409
139S:S:K305 9.955428
140S:S:D307 9.55429
141S:S:L310 9.7875428
142S:S:Q311 10.024529
143S:S:C318 5.664129
144S:S:G322 2.8285385
145S:S:W323 7.6385339
146S:S:C337 3.9756129
147S:S:F345 6.136529
148S:S:Y350 7.815129
149S:S:F358 11.325407
150S:S:I420 3.86408
151S:S:E456 3.92254619
152S:S:I458 3.0375409
153S:S:G461 1.874399
154S:S:L464 2.8054398
155S:S:Y466 7.828577188
156S:S:R488 2.6654199
157S:S:Y496 5.7965199
158S:S:T498 3.805409
159S:S:T500 3.0975407
160S:S:F540 3.75754539
161S:S:W544 6.0185539
162S:S:I559 3.545408
163S:S:K563 3.0925404
164S:S:I569 2.7475405
165S:S:F570 3.875609
166S:S:W578 5.7485539
167S:S:E586 8.26754199
168S:S:L590 3.0054199
169S:S:V603 4.7775409
170S:S:E609 3.0485629
171S:S:E620 8.21754199
172S:S:F627 16.965409
173S:S:H628 6.4925198
174S:S:M643 3.795408
175S:S:Y647 7.99405
176S:S:F648 6.78254189
177S:S:H652 9.436676189
178S:S:T654 4.7875409
179C:C:P19 4.124248
180C:C:M27 8.0254348
181C:C:M34 5.7275408
182C:C:I41 5.6885408
183C:C:P54 4.755408
184C:C:F57 6.6665405
185C:C:S58 3.3125407
186C:C:W65 7.526506
187C:C:E77 6.7725109
188C:C:M85 3.6585346
189C:C:H88 6.234348
190C:C:Y90 10.04754349
191C:C:F92 5.85409
192C:C:H97 6.39599
193C:C:V98 3.185407
194C:C:Y108 6.12408
195C:C:R109 4.69559
196C:C:Q111 4.122559
197C:C:T112 5.37571758
198C:C:Y114 7.354557
199C:C:F115 12.956557
200C:C:Y128 5.608598
201C:C:R135 2.7625499
202C:C:M137 3.724519
203C:C:Q138 10.1975499
204C:C:R142 3.675409
205C:C:Y148 9.364598
206C:C:E149 10.094599
207C:C:F160 4.314678
208C:C:W164 6.7275409
209C:C:F166 10.4954549
210C:C:E172 4.04254519
211C:C:V177 4.87558
212C:C:R181 10.168558
213C:C:E185 10.5875459
214C:C:R186 11.5125499
215C:C:L189 6.3975458
216C:C:Q192 5.902559
217C:C:R194 7.272599
218C:C:F196 11.126559
219C:C:W197 5.398509
220C:C:K215 5.238539
221C:C:Q261 6.83584
222C:C:W265 8.61167685
223C:C:Q266 4.5725484
224C:C:Q268 6.51585
225C:C:R273 8.932584
226C:C:M276 6.974204
227C:C:L291 6.35254211
228C:C:D294 7.6175409
229C:C:F296 4.41754154
230C:C:L297 5.2645214
231C:C:W306 4.48286778
232C:C:W314 9.4525477
233C:C:P322 5.3265255
234C:C:R326 7.135259
235C:C:W330 7.0345259
236C:C:F332 6.6125408
237C:C:M334 10.36405
238C:C:D340 9.3445259
239C:C:V342 5.4985254
240C:C:W363 9.2954276
241C:C:R380 8.125466
242C:C:V381 4.594568
243C:C:Q382 3.58464
244C:C:I384 5.9469
245C:C:W385 9.88143766
246C:C:E387 9.44469
247C:C:L389 8.32333669
248C:C:I397 6.3075468
249C:C:L399 6.282567
250C:C:Y404 6.56167664
251C:C:K406 9.29403
252C:C:T407 5.305669
253C:C:P414 6.184566
254C:C:T418 6.9725465
255C:C:F419 8.0175465
256C:C:I426 7.6054278
257C:C:M430 6.0654279
258C:C:Y435 8.8385269
259C:C:Y444 7.70754269
260B:B:L64 7.758588
261B:B:K65 7.298586
262B:B:L68 6.912587
263B:B:E69 4.9925484
264B:B:E71 5.6425484
265B:B:E79 7.563336204
266B:B:L80 4.2754205
267B:B:L90 6.4054214
268B:B:F93 5.194503
269B:B:H104 6.368509
270B:B:W113 6.7025478
271B:B:W132 11.3865719
272B:B:D133 7.9675478
273B:B:F135 4.905674
274B:B:M145 6.41254728
275B:B:W149 15.978539
276B:B:V150 5.99754729
277B:B:Y155 5.813336357
278B:B:A156 2.8054416
279B:B:C171 2.545438
280B:B:K180 8.7145423
281B:B:N183 5.01754424
282B:B:K188 9.65754734
283B:B:H194 7.3375439
284B:B:Y197 6.928538
285B:B:S202 4.555436
286B:B:F203 2.95754419
287B:B:T204 4.455435
288B:B:S206 4.79254705
289B:B:D207 5.32254418
290B:B:Q209 9.39405
291B:B:T212 6.005439
292B:B:S214 5.6525439
293B:B:G215 4.54438
294B:B:D216 10.355439
295B:B:T218 8.9175437
296B:B:W222 7.954539
297B:B:S226 5.6425406
298B:B:H236 7.234539
299B:B:S256 3.575439
300B:B:G257 2.3407
301B:B:M264 6.4575407
302B:B:W266 11.676539
303B:B:T279 5.9954176
304B:B:H280 7.914179
305B:B:D283 9.00754249
306B:B:R288 6.844574
307B:B:Y289 4.4545366
308B:B:Y290 5.0285696
309B:B:D302 7.4154179
310B:B:R306 6.517178
311B:B:D309 4.8125409
312B:B:R314 9.65254207
313B:B:E315 9.564177
314B:B:Y319 3.5075406
315B:B:I324 5.576676104
316B:B:F326 4.215406
317B:B:R338 6.27219
318B:B:L339 5.6725155
319B:B:F341 7.4245156
320B:B:Y344 9.6245108
321B:B:N345 7.4985247
322B:B:D346 5.6254108
323B:B:Y347 6.79254104
324B:B:T348 5.74254105
325B:B:N350 9.191676106
326B:B:W352 5.1185109
327B:B:L355 4.1325217
328B:B:K356 2.8825406
329B:B:R359 11.28254106
330B:B:I362 9.2345104
331B:B:F364 6.87254104
332B:B:R374 6.32475
333B:B:P377 4.795472
334B:B:D378 8.66167678
335B:B:F382 9.90254155
336B:B:W387 14.9975408
337B:B:D388 7.794749
338B:B:W394 6.575158
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:H328 R:R:Y350 12.04582.18YesYes1499
2R:R:K111 R:R:W323 18.32742.32YesYes139
3R:R:D316 R:R:S319 17.58841.47NoYes087
4R:R:D316 R:R:P339 17.44069.66NoYes088
5R:R:L310 R:R:W323 18.84542.28YesYes189
6R:R:L310 R:R:V283 19.14762.98YesYes086
7R:R:V283 R:R:Y269 20.95753.79YesYes065
8R:R:Y103 R:R:Y269 10.511617.87YesYes155
9R:R:R173 R:R:Y103 11.06582.06YesYes075
10R:R:D307 R:R:Y269 10.488112.64YesYes195
11R:R:D307 R:R:R173 12.490117.87YesYes097
12R:R:G302 R:R:I289 24.13851.76NoYes098
13R:R:G302 R:R:V303 24.11753.68NoYes099
14R:R:K305 R:R:V303 23.9059.11NoYes089
15R:R:A175 R:R:K305 23.714.82NoNo078
16R:R:A175 R:R:Q193 23.68813.03NoNo078
17R:R:Q193 R:R:T195 23.64411.42NoNo088
18R:R:R173 R:R:T195 23.63.88YesNo078
19R:R:I289 R:R:L140 15.47055.71YesNo088
20R:R:F135 R:R:L136 15.20926.09YesNo089
21R:R:F135 S:S:S163 23.00143.96YesNo088
22R:R:V138 S:S:S163 22.96524.85NoNo068
23R:R:V138 S:S:W162 11.5114.9NoYes2967
24S:S:I201 S:S:W162 11.298215.27YesYes2997
25S:S:I201 S:S:L165 22.48898.56YesNo096
26S:S:I171 S:S:L165 22.399712.85YesNo086
27R:R:V138 S:S:E166 11.418111.41NoYes2968
28S:S:E166 S:S:I201 11.29312.73YesYes2989
29R:R:H328 R:R:K329 10.55093.93YesNo095
30R:R:K329 R:R:V391 10.25021.52NoYes053
31S:S:I171 S:S:I308 14.5092.94YesNo086
32S:S:I308 S:S:V283 14.32443.07NoNo066
33S:S:L310 S:S:V283 10.818310.43YesNo286
34R:R:F627 R:R:H650 10.458314.71YesYes1199
35R:R:H650 R:R:R488 42.85427.9YesYes1199
36R:R:H650 R:R:I623 54.46993.98YesYes095
37R:R:I623 R:R:N619 61.80697.08YesNo059
38R:R:N619 R:R:V657 61.90825.91NoNo097
39R:R:L661 R:R:V657 62.21182.98NoNo087
40R:R:L661 R:R:L662 62.41391.38NoNo088
41R:R:L662 R:R:M613 62.51497.07NoNo087
42R:R:K502 R:R:M613 65.52435.76YesNo097
43R:R:K502 R:R:S450 66.32011.53YesNo099
44R:R:K666 R:R:S450 66.39314.59NoNo4799
45R:R:K666 R:R:S446 66.71696.12NoYes098
46R:R:F607 R:R:S446 67.50845.28NoYes088
47R:R:S605 R:R:V603 67.80454.85NoNo099
48R:R:A606 R:R:S605 67.70581.71NoNo099
49R:R:A606 R:R:F607 67.60726.93NoNo098
50R:R:P604 R:R:V603 67.82233.53YesNo5099
51C:C:E149 C:C:L145 68.957410.6YesNo099
52C:C:A150 C:C:L145 68.85931.58NoNo089
53C:C:A150 R:R:P604 68.45283.74NoYes089
54R:R:F540 S:S:W539 40.71234.01NoNo099
55S:S:F540 S:S:W539 40.49976.01YesNo099
56R:R:F540 R:R:T582 40.81892.59NoNo098
57R:R:E586 R:R:T582 40.92644.23YesNo098
58C:C:F196 C:C:W197 12.21738.02YesYes099
59C:C:Q35 R:R:E706 25.231112.74NoNo088
60C:C:P113 R:R:E706 25.15783.14NoNo088
61C:C:P113 C:C:T112 24.71795.25NoYes088
62S:S:I575 S:S:Y580 10.90692.42NoNo068
63S:S:I575 S:S:L574 10.67084.28NoNo067
64S:S:K563 S:S:L574 10.43464.23YesNo047
65S:S:R485 S:S:W544 33.00978NoYes099
66S:S:D579 S:S:R485 32.785716.68NoNo099
67S:S:D579 S:S:F632 14.17422.39NoNo099
68S:S:D579 S:S:T582 18.52647.23NoNo098
69S:S:L489 S:S:T582 18.41124.42NoNo078
70S:S:L489 S:S:R488 18.29652.43NoYes079
71S:S:E620 S:S:S624 17.22535.75YesNo1999
72S:S:E620 S:S:Y496 13.644114.59YesYes1999
73C:C:F57 C:C:Y108 72.416510.32YesYes058
74C:C:P93 C:C:Y108 72.26622.78NoYes098
75C:C:D96 C:C:P93 71.90023.22NoNo099
76C:C:D96 C:C:V98 71.81252.92NoYes097
77C:C:V203 C:C:V98 71.26564.81NoYes097
78C:C:V203 C:C:Y148 70.97036.31NoYes998
79C:C:E149 C:C:Y148 68.196423.57YesYes998
80C:C:I41 C:C:W65 96.83437.05YesYes086
81C:C:F57 C:C:I41 71.60538.79YesYes4058
82C:C:L70 C:C:W65 97.61982.28NoYes076
83C:C:I72 C:C:L70 97.73812.85NoNo057
84C:C:E77 C:C:I72 98.08445.47YesNo095
85B:B:R359 C:C:E77 48.514712.79YesYes1069
86B:B:I362 C:C:E77 48.49588.2YesYes1049
87B:B:G257 B:B:H236 15.93853.18YesYes079
88B:B:C242 B:B:G257 16.06171.96NoYes077
89B:B:C242 B:B:V287 16.10365.12NoNo078
90B:B:F296 B:B:V287 16.31366.55NoNo068
91B:B:F296 B:B:Y289 15.84495.16NoYes3666
92B:B:P247 B:B:Y289 16.39065.56NoYes3646
93B:B:G293 B:B:P247 16.48284.06NoNo084
94B:B:D294 B:B:G293 16.52463.35NoNo038
95B:B:D294 B:B:S292 16.55958.83NoNo035
96B:B:S292 B:B:Y290 16.94042.54NoYes056
97B:B:F333 B:B:Y290 16.61555.16NoYes6986
98B:B:F333 B:B:L340 16.75416.09NoNo087
99B:B:L340 B:B:Y319 16.78622.34NoYes076
100B:B:W352 B:B:Y319 1007.72YesYes096
101B:B:N350 B:B:W352 97.1544.52YesYes1069
102B:B:N350 B:B:R359 48.479510.85YesYes1066
103B:B:I362 B:B:N350 48.63627.08YesYes1046
104B:B:L355 B:B:V354 83.29885.96YesNo075
105B:B:V354 B:B:Y319 83.30832.52NoYes056
106B:B:L355 B:B:R338 80.22836.07YesYes2179
107C:C:E317 C:C:R326 68.738615.12NoYes069
108B:B:K117 C:C:E317 69.01764.05NoNo056
109B:B:D378 B:B:K117 69.296713.83YesNo085
110B:B:D378 C:C:W314 34.97413.35YesYes787
111C:C:P305 C:C:W314 35.093827.02NoYes797
112C:C:N304 C:C:P305 35.3734.89NoNo099
113C:C:L307 C:C:N304 80.67034.12NoNo049
114B:B:R98 C:C:L307 80.93819.72NoNo074
115B:B:A395 B:B:R98 81.07215.53NoNo087
116B:B:A395 C:C:F296 54.6282.77NoYes084
117C:C:D294 C:C:F296 53.65185.97YesYes094
118C:C:D294 C:C:L297 26.76589.5YesYes094
119B:B:R338 C:C:L297 53.63653.64YesYes2194
120B:B:D378 B:B:T380 35.446813.01YesNo785
121B:B:T380 C:C:W306 35.58337.28NoYes758
122C:C:N304 C:C:W306 45.16894.52NoYes098
123B:B:A395 B:B:M95 26.59064.83NoNo085
124B:B:F93 B:B:M95 26.630712.44YesNo035
125B:B:F93 C:C:L297 27.01314.87YesYes034
126B:B:S336 C:C:D294 27.160611.78NoYes099
127B:B:R338 B:B:S336 26.81123.95YesNo099
128C:C:P322 C:C:R326 18.5514.32YesYes2559
129C:C:P322 C:C:V327 17.12663.53YesNo059
130C:C:D340 C:C:R326 46.01778.34YesYes2599
131C:C:L448 C:C:V327 16.54392.98NoNo089
132C:C:L448 C:C:Y444 15.98135.86NoYes2689
133C:C:M430 C:C:W363 26.63219.31YesYes2796
134C:C:L338 C:C:W363 43.60133.42NoYes086
135C:C:L338 C:C:R344 44.14016.07NoNo086
136C:C:P341 C:C:R344 44.41122.88NoNo056
137C:C:D340 C:C:P341 44.6888.05YesNo095
138C:C:M334 C:C:Y435 12.972816.76YesYes059
139C:C:M334 C:C:S434 17.7483.07YesNo059
140C:C:F347 C:C:S434 13.5177.93NoNo099
141C:C:I426 C:C:M430 19.72925.83YesYes2789
142C:C:F362 C:C:V366 18.32777.87NoNo098
143C:C:Q423 C:C:V366 18.656714.33NoNo098
144C:C:Q423 C:C:W363 17.158910.95NoYes096
145C:C:F362 C:C:I426 15.54657.54NoYes098
146C:C:F362 C:C:I397 33.04947.54NoYes098
147C:C:F419 C:C:L389 12.30232.44YesYes659
148C:C:I397 C:C:L389 20.83988.56YesYes689
149R:R:E586 R:R:R488 40.48355.82YesYes1199
150S:S:F540 S:S:W544 33.11282YesYes5399
151C:C:F110 C:C:I41 25.11235.02NoYes4098
152C:C:F110 C:C:Q35 25.304810.54NoNo098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EWP
Class C
SubFamily Orphan
Type C orphans
SubType GPR158
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners B5; RGS7
PDB Resolution 4.3
Date 2021-12-01
D.O.I. 10.1038/s41467-021-27147-1
Net Summary
Imin 1.84
Number of Linked Nodes 1705
Number of Links 2092
Number of Hubs 338
Number of Links mediated by Hubs 1191
Number of Communities 74
Number of Nodes involved in Communities 554
Number of Links involved in Communities 796
Path Summary
Number Of Nodes in MetaPath 153
Number Of Links MetaPath 152
Number of Shortest Paths 6717493
Length Of Smallest Path 3
Average Path Length 50.551
Length of Longest Path 100
Minimum Path Strength 1.205
Average Path Strength 6.38706
Maximum Path Strength 42.4
Minimum Path Correlation 0.73
Average Path Correlation 0.999439
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 9.52381
Average % Of Corr. Nodes 62.7244
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.0096
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ5T848
Sequence
>7EWP_Chain_R
LAQKLAEEV PMDVASYLY TGDSHQLKR ANCSGRYEL AGLPGKWPA 
LASAHPSLH RALDTLTHA TNFLNVMLQ SNKSREQNL QDDLDWYQA 
LVWSLLEGE PSISRAAIT FSTQVFLQA TREESRILL QDPHLANAT 
LETSHFKWS PPYLECENG SYKPGWLVT LSSAIYGLL VPEFRGVMK 
VDINLQKVD IDQCSSDGW FSGTHKCHL NNSECMPIK GLGFVLGAY 
ECICKAGFY HPAYVCLPC REGCPFCAD DSPCFVQED KYLRLAIIS 
FQALCMLLD FVSMLVVYH FRKAKSIRA SGLILLETI LFGSLLLYF 
PVVILYFEP STFRCILLR WARLLGFAT VYGTVTLKL HRVLKVFLS 
RTAQRIPYM TGGRVMRML AVILLVVFW FLIGWTSSV CQNLEKQIS 
LIGQGKTSD HLIFNMCLI DRWDYMTAV AEFLFLLWG VYLCYAVRT 
VPSAFHEPR YMAVAVHNE LIISAIFHT IRFVLASRL QSDWMLMLY 
FAHTHLTVT VTIGLLLIP KFSAWSEHS LDPEDIRDE LKKLYAQLE 
IYKRKKMIT NNPHLQKKR CSKKGLGRS IMRRITEIP E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ5T848
Sequence
>7EWP_Chain_S
LAQKLAEEV PMDVASYLY TGDSHQLKR ANCSGRYEL AGLPGKWPA 
LASAHPSLH RALDTLTHA TNFLNVMLQ SNKSREQNL QDDLDWYQA 
LVWSLLEGE PSISRAAIT FSTQVFLQA TREESRILL QDPHLANAT 
LETSHFKWS PPYLECENG SYKPGWLVT LSSAIYGLL VPEFRGVMK 
VDINLQKVD IDQCSSDGW FSGTHKCHL NNSECMPIK GLGFVLGAY 
ECICKAGFY HPAYVCLPC REGCPFCAD DSPCFVQED KYLRLAIIS 
FQALCMLLD FVSMLVVYH FRKAKSIRA SGLILLETI LFGSLLLYF 
PVVILYFEP STFRCILLR WARLLGFAT VYGTVTLKL HRVLKVFLS 
RTAQRIPYM TGGRVMRML AVILLVVFW FLIGWTSSV CQNLEKQIS 
LIGQGKTSD HLIFNMCLI DRWDYMTAV AEFLFLLWG VYLCYAVRT 
VPSAFHEPR YMAVAVHNE LIISAIFHT IRFVLASRL QSDWMLMLY 
FAHTHLTVT VTIGLLLIP KFSAWSEHS LDPEDIRDE LKKLYAQLE 
IYKRKKMIT NNPHLQKKR CSKKGLGRS IMRRITEIP ELSSSA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainC
ProteinRGP
UniProtP49802
Sequence
>7EWP_Chain_C
SPNMLVYRK MEDVIARMQ DEKNGIPIR TVKSFLSKI PSVFSGSDI 
VQWLIKNLT IEDPVEALH LGTLMAAHG YFFPISDHV LTLKDDGTF 
YRFQTPYFW PSNCWEPEN TDYAVYLCK RTMQNKARL ELADYEAES 
LARLQRAFA RKWEFIFMQ AEAQAKVDK KRDKIERKI LDSQERAFW 
DVHRPVPGC VNTTEVDIK KSSDELQQQ IKYWQIQLD RHRLKMSKV 
ADSLLSYTE QYLEYDPFL LPPDPSNPW LSDDTTFWE LEASKEPSQ 
QRVKRWGFG MDEALKDPV GREQFLKFL ESEFSSENL RFWLAVEDL 
KKRPIKEVP SRVQEIWQE FLAPGAPSA INLDSKSYD KTTQNVKEP 
GRYTFEDAQ EHIYKLMKS DSYPRFIRS SAYQELLQA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtO14775
Sequence
>7EWP_Chain_B
LKSEAESLK GKLEEERAK LHDVELHQV AERVEALGQ FVMKTRRTL 
KGHGNKVLC MDWCKDKRR IVSSSQDGK VIVWDSFTT NKEHAVTMP 
CTWVMACAY APSGCAIAC GGLDNKCSV YPLTFDKNE NMAAKKKSV 
AMHTNYLSA CSFTNSDMQ ILTASGDGT CALWDVESG QLLQSFHGH 
GADVLCLDL APSETGNTF VSGGCDKKA MVWDMRSGQ CVQAFETHE 
SDINSVRYY PSGDAFASG SDDATCRLY DLRADREVA IYSKESIIF 
GASSVDFSL SGRLLFAGY NDYTINVWD VLKGSRVSI LFGHENRVS 
TLRVSPDGT AFCSGSWDH TLRVWA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EWLCOrphanC orphansGPR158Homo sapiens---3.522021-12-0110.1038/s41467-021-27147-1
7EWPCOrphanC orphansGPR158Homo sapiens--B5; RGS74.32021-12-0110.1038/s41467-021-27147-1
7EWRCOrphanC orphansGPR158Homo sapiens--B5; RGS74.72021-12-0110.1038/s41467-021-27147-1
7SHECOrphanC orphansGPR158Homo sapiens-PI; PE-3.42021-12-0110.1126/science.abl4732
7SHFCOrphanC orphansGPR158Homo sapiens-PI; PEB5; RGS73.42021-12-0110.1126/science.abl4732




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EWP.zip



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