Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?402 5.934121710
2H:H:?403 5.727221810
3R:R:R22 3.505405
4R:R:T31 3.7477
5R:R:L45 6.3125407
6R:R:L49 5.105449
7R:R:V53 4.9975446
8R:R:I64 5.142525
9R:R:F67 10.315429
10R:R:C74 5.375427
11R:R:N77 6.0575429
12R:R:I79 7.5925429
13R:R:L87 5.47429
14R:R:Y99 7.64167629
15R:R:R123 9.35409
16R:R:C128 4.8925419
17R:R:P137 4.284509
18R:R:K141 7.795429
19R:R:W143 6.3725409
20R:R:R144 5.8825409
21R:R:F149 6.9775429
22R:R:I160 4.5175409
23R:R:W183 7.978519
24R:R:I194 3.89418
25R:R:D222 7.22515
26R:R:W224 8.044519
27R:R:W229 6.368515
28R:R:K232 5.26519
29R:R:L236 5.5425419
30R:R:S251 5.9875428
31R:R:P253 5.94333629
32R:R:V254 5.845429
33R:R:I260 3.5525409
34R:R:M261 5.9625407
35R:R:V262 3.91754118
36R:R:F275 7.2675414
37R:R:R279 9.576516
38R:R:Y280 6.63417
39R:R:F289 6.15714748
40R:R:T292 5.2275408
41R:R:I307 6.3775408
42R:R:F308 9.89629
43R:R:Q314 6.29429
44R:R:W315 8.036527
45R:R:F318 6.8975429
46R:R:R326 12.855427
47R:R:R327 8.69667925
48S:S:V53 5.4486
49S:S:I64 4.28565
50S:S:F67 10.885439
51S:S:F70 9.8175439
52S:S:L87 4.628539
53S:S:N88 5.9975439
54S:S:S95 5.7625469
55S:S:Y99 7.02167669
56S:S:Y103 5.7025408
57S:S:S115 2.765407
58S:S:Q121 6.42419
59S:S:M126 3.73405
60S:S:C128 5.46419
61S:S:I129 2.5225407
62S:S:F135 3.825418
63S:S:P137 4.638509
64S:S:K141 7.205439
65S:S:W143 7.83409
66S:S:R144 5.59409
67S:S:Y146 11.765459
68S:S:L180 5.815419
69S:S:W183 9.246519
70S:S:D222 6.726515
71S:S:W229 6.498515
72S:S:K232 4.06419
73S:S:L236 5.426519
74S:S:P253 5.35499
75S:S:S257 5.2175409
76S:S:I260 3.44409
77S:S:V277 4.125408
78S:S:R279 9.394516
79S:S:Y280 7.4875417
80S:S:F289 5.30667688
81S:S:F308 9.10667639
82S:S:Q311 6.8425439
83S:S:W315 12.7225437
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1H:H:?402 S:S:S221 34.43917.69YesNo108
2S:S:D222 S:S:S221 34.61022.94YesNo158
3R:R:R279 S:S:D222 64.538310.72YesYes165
4H:H:?403 R:R:R279 99.95847.36YesYes106
5H:H:?402 S:S:R279 1007.92YesYes106
6S:S:D222 S:S:R279 34.49088.34YesYes156
7R:R:D222 S:S:R279 64.381610.72YesYes156
8R:R:D222 R:R:R279 34.538211.91YesYes156
9R:R:D222 R:R:S221 34.4782.94YesNo058
10H:H:?403 R:R:S221 34.49837.69YesNo008
11H:H:?403 R:R:L127 25.7849.67YesNo009
12H:H:?403 R:R:L267 90.50046.45YesNo107
13H:H:?403 R:R:L274 20.35395.8YesNo006
14H:H:?402 S:S:L274 99.69725.8YesNo006
15S:S:L274 S:S:T292 94.56835.9NoNo068
16S:S:F105 S:S:T292 72.52439.08NoNo098
17S:S:F105 S:S:R123 71.881926.72NoNo099
18S:S:I120 S:S:R123 68.653710.02NoNo069
19S:S:C216 S:S:I120 68.00493.27NoNo096
20S:S:C216 S:S:M116 65.25014.86NoNo1296
21S:S:H214 S:S:M116 64.74471.31NoNo056
22S:S:H214 S:S:Q193 64.08949.89NoNo057
23R:R:V201 S:S:Q193 62.77582.87NoNo077
24R:R:V201 R:R:V206 62.11738.02NoNo075
25R:R:V206 S:S:I32 61.45783.07NoNo055
26R:R:M199 S:S:I32 60.13565.83NoNo075
27R:R:C208 R:R:M199 29.73674.86NoNo067
28R:R:C208 S:S:C28 29.05063.64NoNo069
29R:R:V197 S:S:C28 56.704810.25NoNo089
30R:R:V197 S:S:V197 17.19021.6NoNo088
31R:R:L24 S:S:V197 15.76354.47NoNo078
32R:R:M199 S:S:T31 29.73673.01NoNo077
33S:S:C28 S:S:T31 29.05063.38NoNo097
34R:R:L24 R:R:R22 14.33586.07NoYes075
35R:R:S210 R:R:V197 38.46273.23NoNo078
36R:R:S210 S:S:L24 37.0523NoNo077
37R:R:T31 S:S:L24 29.98251.47YesNo077
38R:R:T31 S:S:M199 20.04043.01YesNo077
39R:R:S35 S:S:M199 11.4774.6NoNo057
40R:R:S35 S:S:V201 10.04611.62NoNo057
41R:R:I296 R:R:L127 22.07815.71NoNo099
42R:R:A102 R:R:I296 21.59194.87NoNo089
43R:R:A102 R:R:L57 20.8063.15NoNo089
44R:R:L57 R:R:V53 15.24212.98NoYes096
45R:R:L236 R:R:L267 89.50986.92YesNo197
46R:R:L236 R:R:V264 88.83387.45YesNo098
47R:R:M261 R:R:V264 86.42183.04YesNo078
48R:R:A243 R:R:M261 70.86683.22NoYes097
49R:R:A243 R:R:I260 70.33584.87NoYes099
50R:R:I138 R:R:I260 67.16732.94NoYes089
51R:R:I138 R:R:I307 66.65812.94NoYes088
52R:R:F308 R:R:I307 42.629811.3YesYes098
53R:R:F308 R:R:L92 19.23548.53YesNo298
54R:R:I64 R:R:L92 15.83024.28YesNo258
55R:R:F308 R:R:F67 22.871422.51YesYes299
56R:R:F67 R:R:L312 20.92863.65YesNo298
57R:R:F70 R:R:L312 20.33428.53NoNo298
58R:R:F70 R:R:W315 17.55977.02NoYes297
59R:R:N77 R:R:W315 16.35969.04YesYes297
60R:R:I307 R:R:Q256 18.97638.23YesNo089
61R:R:K141 R:R:Q256 18.40959.49YesNo099
62R:R:K141 R:R:S84 15.26727.65YesNo299
63R:R:R144 R:R:S84 15.57585.27YesNo099
64R:R:L274 R:R:T292 18.83875.9NoYes068
65R:R:F105 R:R:T292 12.905910.38NoYes098
66R:R:F105 R:R:R123 12.107221.38NoYes099
67R:R:I160 R:R:R144 14.83745.01YesYes099
68S:S:I296 S:S:T292 41.66693.04NoNo098
69S:S:A102 S:S:I296 41.18234.87NoNo089
70S:S:A102 S:S:L57 40.72814.73NoNo089
71S:S:L57 S:S:Y103 32.694110.55NoYes098
72S:S:L61 S:S:Y103 30.65115.86NoYes088
73S:S:L61 S:S:Y99 30.3698.21NoYes089
74S:S:I64 S:S:Y99 26.95853.63YesYes659
75S:S:I64 S:S:L92 26.06874.28YesNo058
76S:S:F308 S:S:L92 25.36659.74YesNo098
77S:S:F308 S:S:I307 19.95147.54YesNo098
78S:S:I138 S:S:I307 21.41062.94NoNo088
79S:S:I138 S:S:I260 20.9422.94NoYes089
80S:S:A243 S:S:I260 18.06354.87NoYes099
81S:S:A243 S:S:M261 12.49113.22NoNo097
82R:R:Y241 S:S:M261 12.415914.37NoNo097
83H:H:?402 S:S:L267 10.23695.16YesNo107
84R:R:M261 S:S:Y241 21.928814.37YesNo079
85S:S:L245 S:S:Y241 20.77410.55NoNo599
86S:S:L245 S:S:Y146 20.34716.41NoYes599
87S:S:L57 S:S:V53 11.21532.98NoYes096
88S:S:K147 S:S:Y146 16.09417.17NoYes089
89S:S:K147 S:S:W143 15.623317.4NoYes089
90S:S:I160 S:S:W143 14.00258.22NoYes099
91S:S:I160 S:S:R144 13.13246.26NoYes099
92H:H:?402 S:S:L127 10.99885.16YesNo009
93S:S:L127 S:S:S101 10.21676.01NoNo099
94H:H:?402 S:S:W183 10.260911.14YesYes109
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8YK0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.94
Number of Linked Nodes 585
Number of Links 672
Number of Hubs 83
Number of Links mediated by Hubs 328
Number of Communities 13
Number of Nodes involved in Communities 140
Number of Links involved in Communities 198
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 403381
Length Of Smallest Path 3
Average Path Length 22.116
Length of Longest Path 51
Minimum Path Strength 1.34
Average Path Strength 6.46415
Maximum Path Strength 18.37
Minimum Path Correlation 0.7
Average Path Correlation 0.952512
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 42.806
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.5525
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeMW9
PDB ResiduesH:H:?402 H:H:?403
Environment DetailsOpen EMBL-EBI Page
CodeMW9
Name(21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate
Synonyms1-stearoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)
Identifier
FormulaC42 H81 O10 P
Molecular Weight777.06
SMILES
PubChem24779551
Formal Charge0
Total Atoms134
Total Chiral Atoms2
Total Bonds133
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8NFN8
Sequence
>8YK0_nogp_Chain_R
RPLHDLCKT TITSSHHSS KTISSLSPV LLGIVWTFL SCGLLLILF 
FLAFTIHCR KNRIVKMSS PNLNIVTLL GSCLTYSSA YLFGIQDVL 
VGSSMETLI QTRLSMLCI GTSLVFGPI LGKSWRLYK VFTQRVPDK 
RVIIKDLQL LGLVAALLM ADVILLMTW VLTDPIQCL QILSVSMTV 
TGKDVSCTS TSTHFCASR YSDVWIALI WGCKGLLLL YGAYLAGLT 
GHVSSPPVN QSLTIMVGV NLLVLAAGL LFVVTRYLH SWPNLVFGL 
TSGGIFVCT TTINCFIFI PQLKQWKAF EEENQTIRR MAKYFSTPN 
KS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ8NFN8
Sequence
>8YK0_nogp_Chain_S
RPLHDLCKT TITSSHHSS KTISSLSPV LLGIVWTFL SCGLLLILF 
FLAFTIHCR KNRIVKMSS PNLNIVTLL GSCLTYSSA YLFGIQDVL 
VGSSMETLI QTRLSMLCI GTSLVFGPI LGKSWRLYK VFTQRVPDK 
RVIIKDLQL LGLVAALLM ADVILLMTW VLTDPIQCL QILSVSMTV 
TGKDVSCTS TSTHFCASR YSDVWIALI WGCKGLLLL YGAYLAGLT 
GHVSSPPVN QSLTIMVGV NLLVLAAGL LFVVTRYLH SWPNLVFGL 
TSGGIFVCT TTINCFIFI PQLKQWKAF E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YJPCOrphanOrphanGPR156Homo sapiens---3.092025-02-05doi.org/10.1038/s41467-024-54681-5
8YK0COrphanOrphanGPR156Homo sapiens--Gi3/β1/γ22.42025-02-05doi.org/10.1038/s41467-024-54681-5
8YK0 (No Gprot) COrphanOrphanGPR156Homo sapiens--2.42025-02-05doi.org/10.1038/s41467-024-54681-5
8IEPCOrphanOrphanGPR156Homo sapiensA1LYA--2.612024-02-14doi.org/10.1038/s41594-024-01224-7
8IEICOrphanOrphanGPR156Homo sapiensA1LYA--2.622024-02-14doi.org/10.1038/s41594-024-01224-7
8IEBCOrphanOrphanGPR156Homo sapiensA1LYA--3.032024-02-14doi.org/10.1038/s41594-024-01224-7
8IEDCOrphanOrphanGPR156Homo sapiensA1LYA-Go/β1/γ23.332024-02-14doi.org/10.1038/s41594-024-01224-7
8IED (No Gprot) COrphanOrphanGPR156Homo sapiensA1LYA-3.332024-02-14doi.org/10.1038/s41594-024-01224-7




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8YK0_nogp.zip



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