psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L124	10.95	Yes	No	1	0	5
2	L:L:?1	R:R:L127	3.91	Yes	No	0	0	9
3	L:L:?1	R:R:T131	6.66	Yes	No	0	0	8
4	L:L:?1	R:R:W183	7.72	Yes	Yes	1	0	9
5	L:L:?1	R:R:I189	4.03	Yes	Yes	1	0	6
6	L:L:?1	R:R:F215	5.5	Yes	Yes	1	0	5
7	L:L:?1	R:R:A217	6.23	Yes	No	0	0	8
8	L:L:?1	R:R:S221	6.79	Yes	No	0	0	8
9	L:L:?1	R:R:I225	5.64	Yes	No	1	0	7
10	L:L:?1	R:R:I228	4.03	Yes	No	0	0	6
11	L:L:?1	R:R:W229	17.37	Yes	No	1	0	5
12	L:L:?1	R:R:K232	5.58	Yes	No	0	0	9
13	L:L:?1	R:R:L267	6.26	Yes	No	0	0	7
14	L:L:?1	R:R:A271	3.56	Yes	No	1	0	7
15	L:L:?1	R:R:L274	4.69	Yes	No	0	0	6
16	L:L:?1	R:R:T278	8.33	Yes	No	0	0	8
17	L:L:?1	R:R:R279	9.61	Yes	Yes	0	0	6
18	L:L:?1	R:R:H282	4.36	Yes	No	0	0	5
19	L:L:?1	R:R:C299	3.59	Yes	No	0	0	9
20	M:M:?1	S:S:L124	10.95	Yes	No	2	0	5
21	M:M:?1	S:S:L127	4.69	Yes	No	0	0	9
22	M:M:?1	S:S:C128	4.48	Yes	No	0	0	9
23	M:M:?1	S:S:T131	6.66	Yes	No	0	0	8
24	M:M:?1	S:S:W183	10.3	Yes	Yes	2	0	9
25	M:M:?1	S:S:F215	4.13	Yes	No	0	0	5
26	M:M:?1	S:S:A217	4.45	Yes	No	0	0	8
27	M:M:?1	S:S:S221	9.33	Yes	No	0	0	8
28	M:M:?1	S:S:I225	4.03	Yes	No	2	0	7
29	M:M:?1	S:S:W229	8.37	Yes	Yes	2	0	5
30	M:M:?1	S:S:K232	9.56	Yes	Yes	0	0	9
31	M:M:?1	S:S:L267	7.04	Yes	No	2	0	7
32	M:M:?1	S:S:L274	3.91	Yes	No	0	0	6
33	M:M:?1	S:S:F275	6.88	Yes	No	2	0	4
34	M:M:?1	S:S:T278	9.16	Yes	No	0	0	8
35	M:M:?1	S:S:R279	8.24	Yes	Yes	2	0	6
36	M:M:?1	S:S:C299	3.59	Yes	No	0	0	9
37	R:R:L45	R:R:Q108	3.99	Yes	No	0	7	6
38	R:R:L45	R:R:N286	6.87	Yes	No	0	7	9
39	R:R:F289	R:R:L45	6.09	Yes	Yes	0	8	7
40	R:R:L49	R:R:S46	4.5	No	No	0	9	9
41	R:R:N286	R:R:S46	7.45	No	No	0	9	9
42	R:R:F289	R:R:L49	4.87	Yes	No	0	8	9
43	R:R:L50	R:R:W54	4.56	No	No	0	5	7
44	R:R:F289	R:R:L50	3.65	Yes	No	0	8	5
45	R:R:F289	R:R:V53	9.18	Yes	No	10	8	6
46	R:R:S293	R:R:V53	4.85	No	No	10	9	6
47	R:R:W54	R:R:Y103	19.29	No	No	0	7	8
48	R:R:A102	R:R:L57	3.15	No	No	0	8	9
49	R:R:L57	R:R:Y103	10.55	No	No	0	9	8
50	R:R:F297	R:R:L57	3.65	Yes	No	0	8	9
51	R:R:S58	R:R:Y103	5.09	No	No	0	9	8
52	R:R:G60	R:R:Y99	4.35	No	Yes	0	9	9
53	R:R:L61	R:R:Y99	3.52	No	Yes	0	8	9
54	R:R:F67	R:R:L63	9.74	No	No	0	9	8
55	R:R:I64	R:R:L92	5.71	Yes	No	0	5	8
56	R:R:I64	R:R:S95	9.29	Yes	Yes	4	5	9
57	R:R:I64	R:R:Y99	3.63	Yes	Yes	4	5	9
58	R:R:I64	R:R:N304	7.08	Yes	No	4	5	9
59	R:R:F66	R:R:F67	4.29	No	No	0	6	9
60	R:R:F308	R:R:F67	17.15	Yes	No	0	9	9
61	R:R:C74	R:R:F70	5.59	No	No	3	7	9
62	R:R:F70	R:R:L312	13.4	No	No	0	9	8
63	R:R:F70	R:R:W315	7.02	No	Yes	3	9	7
64	R:R:I89	R:R:T71	4.56	No	No	0	5	9
65	R:R:F308	R:R:T71	3.89	Yes	No	0	9	9
66	R:R:C74	R:R:H73	5.9	No	No	0	7	8
67	R:R:C74	R:R:W315	7.84	No	Yes	3	7	7
68	R:R:I79	R:R:N77	4.25	Yes	Yes	3	9	9
69	R:R:N77	R:R:V80	4.43	Yes	No	0	9	9
70	R:R:N77	R:R:W315	11.3	Yes	Yes	3	9	7
71	R:R:E319	R:R:N77	10.52	No	Yes	3	8	9
72	R:R:N322	R:R:R78	18.08	No	No	0	6	9
73	R:R:M328	R:R:R78	6.2	Yes	No	0	9	9
74	R:R:I79	R:R:P253	5.08	Yes	Yes	3	9	9
75	R:R:F318	R:R:I79	7.54	Yes	Yes	3	9	9
76	R:R:I79	R:R:Y331	7.25	Yes	Yes	3	9	9
77	R:R:P85	R:R:V80	3.53	No	No	0	9	9
78	R:R:F332	R:R:M82	3.73	No	No	0	9	9
79	R:R:N88	R:R:S83	4.47	Yes	No	5	9	9
80	R:R:Q311	R:R:S83	5.78	No	No	5	9	9
81	R:R:L87	R:R:S84	6.01	Yes	No	5	9	9
82	R:R:K141	R:R:S84	7.65	Yes	No	5	9	9
83	R:R:R144	R:R:S84	5.27	Yes	No	0	9	9
84	R:R:N86	R:R:P85	3.26	No	No	0	9	9
85	R:R:D162	R:R:N86	6.73	No	No	0	9	9
86	R:R:L87	R:R:P137	6.57	Yes	Yes	0	9	9
87	R:R:K141	R:R:L87	5.64	Yes	Yes	5	9	9
88	R:R:L165	R:R:L87	4.15	Yes	Yes	0	9	9
89	R:R:K141	R:R:N88	6.99	Yes	Yes	5	9	9
90	R:R:F308	R:R:N88	7.25	Yes	Yes	5	9	9
91	R:R:N88	R:R:Q311	3.96	Yes	No	5	9	9
92	R:R:P137	R:R:V90	3.53	Yes	No	0	9	9
93	R:R:T91	R:R:V134	3.17	No	No	0	9	8
94	R:R:P137	R:R:T91	5.25	Yes	No	0	9	9
95	R:R:F308	R:R:L92	9.74	Yes	No	0	9	8
96	R:R:G94	R:R:L133	3.42	Yes	No	0	9	9
97	R:R:S95	R:R:Y99	3.82	Yes	Yes	4	9	9
98	R:R:S95	R:R:T300	3.2	Yes	No	4	9	9
99	R:R:N304	R:R:S95	8.94	No	Yes	4	9	9
100	R:R:S101	R:R:T98	3.2	No	No	0	9	9
101	R:R:T300	R:R:T98	7.85	No	No	0	9	9
102	R:R:F297	R:R:Y99	4.13	Yes	Yes	4	8	9
103	R:R:T300	R:R:Y99	9.99	No	Yes	4	9	9
104	R:R:T301	R:R:Y99	6.24	No	Yes	4	8	9
105	R:R:M126	R:R:S100	4.6	No	No	0	5	5
106	R:R:L127	R:R:S101	9.01	No	No	0	9	9
107	R:R:A102	R:R:I296	4.87	No	No	0	8	9
108	R:R:F105	R:R:R123	10.69	No	No	0	9	9
109	R:R:F105	R:R:L127	3.65	No	No	0	9	9
110	R:R:F105	R:R:T292	7.78	No	No	0	9	8
111	R:R:F289	R:R:G106	4.52	Yes	No	0	8	8
112	R:R:L111	R:R:S115	7.51	No	No	0	4	7
113	R:R:S115	R:R:T118	3.2	No	No	0	7	6
114	R:R:L119	R:R:R123	3.64	Yes	No	0	6	9
115	R:R:I120	R:R:R123	6.26	No	No	0	6	9
116	R:R:Q121	R:R:W183	9.86	No	Yes	1	9	9
117	R:R:Q121	R:R:V184	4.3	No	No	1	9	7
118	R:R:I189	R:R:Q121	8.23	Yes	No	1	6	9
119	R:R:L124	R:R:W183	4.56	No	Yes	1	5	9
120	R:R:L180	R:R:S125	9.01	No	No	0	9	8
121	R:R:C128	R:R:D176	9.34	No	Yes	13	9	9
122	R:R:C128	R:R:L180	3.17	No	No	13	9	9
123	R:R:C128	R:R:K232	3.23	No	No	0	9	9
124	R:R:I129	R:R:L173	4.28	No	No	0	7	7
125	R:R:D176	R:R:I129	4.2	Yes	No	0	9	7
126	R:R:D176	R:R:S132	5.89	Yes	No	0	9	9
127	R:R:K232	R:R:S132	4.59	No	No	0	9	9
128	R:R:F135	R:R:L267	3.65	No	No	0	8	7
129	R:R:G136	R:R:P137	4.06	No	Yes	0	9	9
130	R:R:P137	R:R:V169	3.53	Yes	No	0	9	9
131	R:R:G239	R:R:L139	5.13	No	No	0	9	9
132	R:R:G140	R:R:L165	3.42	No	Yes	0	9	9
133	R:R:K141	R:R:Q256	5.42	Yes	No	0	9	9
134	R:R:S142	R:R:T246	3.2	No	No	0	9	9
135	R:R:K147	R:R:W143	6.96	No	No	0	8	9
136	R:R:L242	R:R:W143	3.42	No	No	0	9	9
137	R:R:I160	R:R:R144	7.52	No	Yes	0	9	9
138	R:R:D162	R:R:R144	4.76	No	Yes	0	9	9
139	R:R:L165	R:R:R144	4.86	Yes	Yes	0	9	9
140	R:R:L145	R:R:V254	4.47	No	No	0	9	9
141	R:R:T150	R:R:Y146	13.73	No	No	0	9	9
142	R:R:L245	R:R:Y146	14.07	No	No	0	9	9
143	R:R:Y146	S:S:H248	3.27	No	No	0	9	8
144	R:R:K147	R:R:Q151	5.42	No	No	0	8	9
145	R:R:F149	R:R:V148	6.55	No	No	0	9	9
146	R:R:F149	R:R:V249	5.24	No	Yes	0	9	9
147	R:R:Q151	R:R:V158	7.16	No	No	0	9	9
148	R:R:R152	R:R:T334	10.35	No	No	0	9	9
149	R:R:P154	R:R:V153	5.3	No	No	0	9	8
150	R:R:I159	R:R:K161	4.36	No	No	0	9	9
151	R:R:I160	R:R:Q164	4.12	No	No	0	9	9
152	R:R:L172	R:R:L235	9.69	No	No	0	9	8
153	R:R:D176	R:R:L180	6.79	Yes	No	13	9	9
154	R:R:L179	R:R:L227	5.54	No	No	0	7	7
155	R:R:T182	R:R:W224	3.64	No	Yes	0	5	9
156	R:R:V184	R:R:W183	3.68	No	Yes	1	7	9
157	R:R:I189	R:R:W183	7.05	Yes	Yes	1	6	9
158	R:R:W183	R:R:W224	14.06	Yes	Yes	1	9	9
159	R:R:T186	R:R:W224	7.28	No	Yes	0	7	9
160	R:R:D187	R:R:P188	3.22	Yes	No	0	9	9
161	R:R:D187	R:R:S218	8.83	Yes	No	1	9	9
162	R:R:D187	R:R:R219	3.57	Yes	No	1	9	3
163	R:R:D187	R:R:Y220	4.6	Yes	No	1	9	8
164	R:R:D187	R:R:W224	5.58	Yes	Yes	1	9	9
165	R:R:C191	R:R:C216	7.28	No	Yes	1	9	9
166	R:R:I194	R:R:L192	5.71	No	Yes	1	8	7
167	R:R:F215	R:R:L192	4.87	Yes	Yes	1	5	7
168	R:R:H214	R:R:Q193	3.71	No	No	0	5	7
169	R:R:F215	R:R:I194	3.77	Yes	No	1	5	8
170	R:R:S210	R:R:V197	4.85	No	No	0	7	8
171	R:R:S198	S:S:S196	3.26	No	No	0	7	4
172	R:R:C208	R:R:M199	6.48	No	No	0	6	7
173	R:R:M199	S:S:L195	4.24	No	No	0	7	7
174	R:R:T200	S:S:L192	4.42	No	No	0	7	7
175	R:R:V201	R:R:V206	4.81	No	No	0	7	5
176	R:R:G203	R:R:T202	3.64	No	No	0	5	5
177	R:R:F215	R:R:T213	3.89	Yes	No	0	5	5
178	R:R:S218	R:R:S221	3.26	No	No	0	9	8
179	R:R:S218	R:R:W224	3.71	No	Yes	1	9	9
180	R:R:R219	R:R:Y220	10.29	No	No	1	3	8
181	R:R:V223	R:R:Y220	5.05	No	No	0	6	8
182	R:R:D222	R:R:R279	8.34	No	Yes	0	5	6
183	R:R:D222	S:S:R279	13.1	No	Yes	2	5	6
184	R:R:D222	S:S:Y280	5.75	No	No	2	5	7
185	R:R:V223	S:S:Y280	3.79	No	No	0	6	7
186	R:R:I225	R:R:W229	9.4	No	No	1	7	5
187	R:R:F275	R:R:I225	3.77	No	No	0	4	7
188	R:R:A271	R:R:W229	3.89	No	No	1	7	5
189	R:R:G233	R:R:L236	5.13	No	Yes	0	8	9
190	R:R:L234	S:S:N265	5.49	No	No	0	6	7
191	R:R:L236	R:R:V264	5.96	Yes	No	14	9	8
192	R:R:L236	S:S:L237	4.15	Yes	No	14	9	7
193	R:R:L237	S:S:L237	4.15	No	No	0	7	7
194	R:R:L237	S:S:V264	4.47	No	No	0	7	8
195	R:R:Y238	R:R:Y241	3.97	No	Yes	0	8	9
196	R:R:L242	R:R:Y238	5.86	No	No	0	9	8
197	R:R:L245	R:R:Y241	10.55	No	Yes	0	9	9
198	R:R:Y241	S:S:M261	9.58	Yes	No	0	9	7
199	R:R:A243	R:R:I260	4.87	No	No	0	9	9
200	R:R:A243	R:R:M261	3.22	No	Yes	0	9	7
201	R:R:G244	S:S:Y241	4.35	No	No	0	9	9
202	R:R:T246	R:R:V249	4.76	No	Yes	0	9	9
203	R:R:S257	R:R:T246	3.2	No	No	0	9	9
204	R:R:G247	R:R:S257	3.71	No	No	0	7	9
205	R:R:H248	S:S:Y146	5.44	No	Yes	0	8	9
206	R:R:S250	R:R:V249	3.23	No	Yes	0	9	9
207	R:R:N255	R:R:V249	4.43	No	Yes	0	9	9
208	R:R:S250	R:R:V254	8.08	No	No	0	9	9
209	R:R:S251	R:R:Y331	16.53	No	Yes	0	8	9
210	R:R:P252	R:R:P253	5.84	No	Yes	0	9	9
211	R:R:P253	R:R:P310	3.9	Yes	No	0	9	9
212	R:R:P253	R:R:Q314	6.32	Yes	No	3	9	9
213	R:R:P253	R:R:Y331	11.13	Yes	Yes	3	9	9
214	R:R:N255	R:R:S257	8.94	No	No	0	9	9
215	R:R:Q256	R:R:T259	7.09	No	No	0	9	9
216	R:R:F306	R:R:L258	7.31	No	No	0	7	6
217	R:R:F306	R:R:T259	5.19	No	No	0	7	9
218	R:R:M261	S:S:Y241	11.97	Yes	No	0	7	9
219	R:R:F306	R:R:V262	6.55	No	No	0	7	8
220	R:R:G263	R:R:I303	3.53	No	No	0	7	8
221	R:R:V264	S:S:L237	10.43	No	No	14	8	7
222	R:R:L266	R:R:T302	4.42	No	No	0	8	8
223	R:R:V268	S:S:L234	4.47	No	No	0	7	6
224	R:R:L274	R:R:T292	5.9	No	No	0	6	8
225	R:R:F275	R:R:R279	9.62	No	Yes	0	4	6
226	R:R:L291	R:R:V277	4.47	No	No	0	5	8
227	R:R:T278	R:R:V288	4.76	No	No	0	8	8
228	R:R:R279	S:S:D222	14.29	Yes	Yes	0	6	5
229	R:R:Y280	S:S:Y220	8.94	No	No	15	7	8
230	R:R:Y280	S:S:D222	9.2	No	Yes	0	7	5
231	R:R:L281	R:R:W284	6.83	No	No	0	8	8
232	R:R:L287	R:R:W284	3.42	No	No	0	8	8
233	R:R:L287	R:R:L291	4.15	No	No	0	8	5
234	R:R:F289	R:R:G290	4.52	Yes	No	0	8	7
235	R:R:F289	R:R:S293	5.28	Yes	No	10	8	9
236	R:R:F297	R:R:T301	11.67	Yes	No	4	8	8
237	R:R:C305	R:R:I309	4.91	No	No	0	9	8
238	R:R:F308	R:R:I307	11.3	Yes	No	0	9	8
239	R:R:F308	R:R:Q311	3.51	Yes	No	5	9	9
240	R:R:I309	R:R:P310	3.39	No	No	0	8	9
241	R:R:K313	R:R:Q314	8.14	No	No	0	7	9
242	R:R:Q314	R:R:Y331	4.51	No	Yes	3	9	9
243	R:R:E319	R:R:W315	19.63	No	Yes	3	8	7
244	R:R:F318	R:R:M328	8.71	Yes	Yes	3	9	9
245	R:R:F318	R:R:Y331	7.22	Yes	Yes	3	9	9
246	R:R:E319	R:R:E320	7.61	No	No	0	8	8
247	R:R:R326	R:R:T324	5.17	No	No	0	7	8
248	R:R:I325	R:R:R326	3.76	No	No	0	5	7
249	R:R:M328	R:R:Y331	4.79	Yes	Yes	3	9	9
250	R:R:P335	R:R:T334	3.5	No	No	0	9	9
251	S:S:L45	S:S:N286	5.49	No	No	0	7	9
252	S:S:F289	S:S:L45	3.65	Yes	No	0	8	7
253	S:S:P47	S:S:S46	3.56	No	No	0	7	9
254	S:S:S46	S:S:V48	3.23	No	No	0	9	8
255	S:S:L49	S:S:N286	4.12	No	No	0	9	9
256	S:S:F289	S:S:L49	4.87	Yes	No	0	8	9
257	S:S:L50	S:S:W54	14.81	No	No	0	5	7
258	S:S:F289	S:S:L50	3.65	Yes	No	0	8	5
259	S:S:F289	S:S:V53	9.18	Yes	No	16	8	6
260	S:S:S293	S:S:V53	4.85	No	No	16	9	6
261	S:S:W54	S:S:Y103	6.75	No	Yes	0	7	8
262	S:S:A102	S:S:L57	3.15	No	No	0	8	9
263	S:S:L57	S:S:Y103	8.21	No	Yes	0	9	8
264	S:S:F297	S:S:L57	3.65	Yes	No	0	8	9
265	S:S:G60	S:S:Y99	4.35	No	Yes	0	9	9
266	S:S:L61	S:S:Y99	8.21	No	Yes	0	8	9
267	S:S:L61	S:S:Y103	3.52	No	Yes	0	8	8
268	S:S:F67	S:S:L63	7.31	No	No	0	9	8
269	S:S:I64	S:S:L92	4.28	Yes	No	0	5	8
270	S:S:I64	S:S:S95	4.64	Yes	No	6	5	9
271	S:S:I64	S:S:Y99	3.63	Yes	Yes	6	5	9
272	S:S:I64	S:S:N304	5.66	Yes	No	6	5	9
273	S:S:F308	S:S:F67	13.93	Yes	No	0	9	9
274	S:S:L68	S:S:L92	6.92	No	No	0	6	8
275	S:S:C74	S:S:F70	4.19	No	Yes	7	7	9
276	S:S:F70	S:S:V80	3.93	Yes	No	7	9	9
277	S:S:F70	S:S:Q311	4.68	Yes	Yes	7	9	9
278	S:S:F70	S:S:L312	10.96	Yes	No	0	9	8
279	S:S:F70	S:S:W315	9.02	Yes	No	7	9	7
280	S:S:C74	S:S:W315	3.92	No	No	7	7	7
281	S:S:N77	S:S:V80	5.91	No	No	0	9	9
282	S:S:N77	S:S:W315	4.52	No	No	0	9	7
283	S:S:I79	S:S:R78	5.01	No	No	0	9	9
284	S:S:M82	S:S:R78	4.96	No	No	0	9	9
285	S:S:I79	S:S:Q314	6.86	No	No	0	9	9
286	S:S:Q311	S:S:V80	5.73	Yes	No	7	9	9
287	S:S:K81	S:S:P85	3.35	No	No	0	9	9
288	S:S:Q311	S:S:S83	5.78	Yes	No	0	9	9
289	S:S:L87	S:S:S84	4.5	Yes	Yes	8	9	9
290	S:S:K141	S:S:S84	6.12	No	Yes	0	9	9
291	S:S:R144	S:S:S84	3.95	Yes	Yes	8	9	9
292	S:S:D162	S:S:N86	14.81	No	No	0	9	9
293	S:S:L87	S:S:P137	4.93	Yes	Yes	0	9	9
294	S:S:L87	S:S:R144	3.64	Yes	Yes	8	9	9
295	S:S:L165	S:S:L87	4.15	No	Yes	8	9	9
296	S:S:K141	S:S:N88	5.6	No	No	0	9	9
297	S:S:F308	S:S:N88	7.25	Yes	No	0	9	9
298	S:S:P137	S:S:V90	7.07	Yes	No	0	9	9
299	S:S:P137	S:S:T91	5.25	Yes	No	0	9	9
300	S:S:F308	S:S:L92	3.65	Yes	No	0	9	8
301	S:S:G94	S:S:L133	3.42	No	No	0	9	9
302	S:S:S95	S:S:T300	3.2	No	No	0	9	9
303	S:S:N304	S:S:S95	8.94	No	No	6	9	9
304	S:S:L97	S:S:M126	4.24	No	No	0	8	5
305	S:S:G130	S:S:L97	5.13	No	No	0	9	8
306	S:S:T300	S:S:T98	6.28	No	No	0	9	9
307	S:S:F297	S:S:Y99	7.22	Yes	Yes	6	8	9
308	S:S:T300	S:S:Y99	11.24	No	Yes	0	9	9
309	S:S:T301	S:S:Y99	6.24	No	Yes	6	8	9
310	S:S:M126	S:S:S100	6.13	No	No	0	5	5
311	S:S:M126	S:S:S101	4.6	No	No	0	5	9
312	S:S:L127	S:S:S101	7.51	No	No	0	9	9
313	S:S:A102	S:S:I296	4.87	No	No	0	8	9
314	S:S:I107	S:S:L104	4.28	No	Yes	9	6	8
315	S:S:L104	S:S:L119	4.15	Yes	No	9	8	6
316	S:S:L104	S:S:R123	3.64	Yes	Yes	9	8	9
317	S:S:F105	S:S:R123	13.9	No	Yes	0	9	9
318	S:S:F105	S:S:T292	7.78	No	No	0	9	8
319	S:S:F105	S:S:I296	3.77	No	No	0	9	9
320	S:S:F289	S:S:G106	4.52	Yes	No	0	8	8
321	S:S:I107	S:S:L119	4.28	No	No	9	6	6
322	S:S:M116	S:S:Q108	5.44	No	No	0	6	6
323	S:S:Q108	S:S:R123	3.5	No	Yes	0	6	9
324	S:S:S115	S:S:V110	4.85	No	No	0	7	4
325	S:S:C191	S:S:E117	10.64	No	No	0	9	6
326	S:S:L119	S:S:R123	3.64	No	Yes	9	6	9
327	S:S:I120	S:S:R123	12.53	No	Yes	0	6	9
328	S:S:C216	S:S:I120	3.27	No	No	0	9	6
329	S:S:Q121	S:S:W183	3.29	No	Yes	2	9	9
330	S:S:Q121	S:S:V184	10.03	No	Yes	2	9	7
331	S:S:I189	S:S:Q121	6.86	No	No	2	6	9
332	S:S:L124	S:S:W183	3.42	No	Yes	2	5	9
333	S:S:I296	S:S:L127	7.14	No	No	0	9	9
334	S:S:C128	S:S:L180	3.17	No	No	0	9	9
335	S:S:L173	S:S:S132	9.01	No	No	0	7	9
336	S:S:D176	S:S:S132	5.89	No	No	0	9	9
337	S:S:L133	S:S:L173	9.69	No	No	17	9	7
338	S:S:F135	S:S:L236	4.87	No	Yes	2	8	9
339	S:S:F135	S:S:L267	3.65	No	No	2	8	7
340	S:S:G136	S:S:P137	4.06	No	Yes	0	9	9
341	S:S:P137	S:S:V169	3.53	Yes	No	0	9	9
342	S:S:G239	S:S:L139	5.13	No	No	0	9	9
343	S:S:G140	S:S:L165	3.42	No	No	0	9	9
344	S:S:K141	S:S:Q256	4.07	No	No	0	9	9
345	S:S:S142	S:S:T246	3.2	No	No	0	9	9
346	S:S:K147	S:S:W143	5.8	No	No	0	8	9
347	S:S:L242	S:S:W143	4.56	No	No	0	9	9
348	S:S:I160	S:S:R144	6.26	No	Yes	0	9	9
349	S:S:D162	S:S:R144	8.34	No	Yes	0	9	9
350	S:S:L165	S:S:R144	10.93	No	Yes	8	9	9
351	S:S:L145	S:S:T246	5.9	Yes	No	0	9	9
352	S:S:L145	S:S:V249	4.47	Yes	No	18	9	9
353	S:S:L145	S:S:S250	4.5	Yes	Yes	18	9	9
354	S:S:K147	S:S:Y146	3.58	No	Yes	0	8	9
355	S:S:T150	S:S:Y146	9.99	No	Yes	0	9	9
356	S:S:L245	S:S:Y146	17.58	No	Yes	0	9	9
357	S:S:K147	S:S:Q151	13.56	No	No	0	8	9
358	S:S:F149	S:S:T150	5.19	No	No	0	9	9
359	S:S:F149	S:S:V249	3.93	No	No	0	9	9
360	S:S:P154	S:S:V153	3.53	No	No	0	9	8
361	S:S:I160	S:S:Q164	9.61	No	No	0	9	9
362	S:S:L172	S:S:L235	6.92	No	No	0	9	8
363	S:S:D176	S:S:K232	8.3	No	Yes	0	9	9
364	S:S:C231	S:S:L179	3.17	No	No	0	6	7
365	S:S:T182	S:S:W224	7.28	No	Yes	0	5	9
366	S:S:V184	S:S:W183	3.68	Yes	Yes	2	7	9
367	S:S:I189	S:S:W183	4.7	No	Yes	2	6	9
368	S:S:S218	S:S:W183	6.18	No	Yes	0	9	9
369	S:S:W183	S:S:W224	18.74	Yes	Yes	2	9	9
370	S:S:D187	S:S:T186	4.34	No	No	2	9	7
371	S:S:T186	S:S:W224	4.85	No	Yes	2	7	9
372	S:S:D187	S:S:W224	14.52	No	Yes	2	9	9
373	S:S:P188	S:S:Q190	6.32	No	No	0	9	7
374	S:S:L192	S:S:Q190	5.32	No	No	0	7	7
375	S:S:C191	S:S:C216	7.28	No	No	0	9	9
376	S:S:H214	S:S:Q193	4.95	No	No	0	5	7
377	S:S:S196	S:S:T211	3.2	No	No	0	4	8
378	S:S:S210	S:S:V197	4.85	No	No	0	7	8
379	S:S:S198	S:S:T209	3.2	No	No	0	7	8
380	S:S:C208	S:S:M199	4.86	No	Yes	0	6	7
381	S:S:S207	S:S:T200	3.2	No	No	0	7	7
382	S:S:V201	S:S:V206	8.02	No	No	19	7	5
383	S:S:F215	S:S:T213	5.19	No	No	0	5	5
384	S:S:D222	S:S:I225	4.2	Yes	No	0	5	7
385	S:S:D222	S:S:R279	9.53	Yes	Yes	0	5	6
386	S:S:F275	S:S:I225	8.79	No	No	2	4	7
387	S:S:A271	S:S:W229	3.89	No	Yes	0	7	5
388	S:S:F275	S:S:W229	11.02	No	Yes	2	4	5
389	S:S:C231	S:S:K232	6.47	No	Yes	0	6	9
390	S:S:L236	S:S:V264	13.41	Yes	No	0	9	8
391	S:S:L236	S:S:L267	6.92	Yes	No	2	9	7
392	S:S:L242	S:S:Y238	8.21	No	No	0	9	8
393	S:S:L245	S:S:Y241	7.03	No	No	0	9	9
394	S:S:S250	S:S:V249	4.85	Yes	No	18	9	9
395	S:S:S250	S:S:V254	3.23	Yes	No	0	9	9
396	S:S:P253	S:S:S251	8.91	Yes	No	0	9	8
397	S:S:P252	S:S:P253	5.84	No	Yes	0	9	9
398	S:S:P253	S:S:P310	3.9	Yes	No	0	9	9
399	S:S:N255	S:S:S257	4.47	No	No	0	9	9
400	S:S:Q256	S:S:T259	14.17	No	No	0	9	9
401	S:S:I307	S:S:Q256	6.86	Yes	No	0	8	9
402	S:S:M261	S:S:N265	4.21	No	No	0	7	7
403	S:S:F306	S:S:V262	5.24	Yes	No	0	7	8
404	S:S:G263	S:S:I303	3.53	No	No	0	7	8
405	S:S:L266	S:S:L269	5.54	No	No	0	8	5
406	S:S:L266	S:S:T302	4.42	No	No	0	8	8
407	S:S:L274	S:S:T292	4.42	No	No	0	6	8
408	S:S:L281	S:S:V277	8.94	No	Yes	0	8	8
409	S:S:L291	S:S:V277	5.96	No	Yes	0	5	8
410	S:S:R279	S:S:Y280	6.17	Yes	No	2	6	7
411	S:S:L281	S:S:L287	5.54	No	No	0	8	8
412	S:S:S283	S:S:W284	4.94	No	No	0	5	8
413	S:S:L287	S:S:W284	6.83	No	No	0	8	8
414	S:S:L287	S:S:L291	4.15	No	No	0	8	5
415	S:S:F289	S:S:G290	4.52	Yes	No	0	8	7
416	S:S:F289	S:S:S293	6.61	Yes	No	16	8	9
417	S:S:F297	S:S:T301	9.08	Yes	No	6	8	8
418	S:S:F308	S:S:I307	11.3	Yes	Yes	0	9	8
419	S:S:F308	S:S:Q311	7.03	Yes	Yes	0	9	9
420	S:S:I309	S:S:P310	3.39	No	No	0	8	9
421	S:S:I309	S:S:K313	4.36	No	No	0	8	7
422	R:R:T209	R:R:T211	3.14	No	No	0	8	8
423	S:S:T209	S:S:T211	3.14	No	No	0	8	8
424	S:S:T211	S:S:T213	3.14	No	No	0	8	5
425	R:R:I260	R:R:S142	3.1	No	No	0	9	9
426	R:R:M126	R:R:S101	3.07	No	No	0	5	9
427	R:R:I107	R:R:V110	3.07	No	No	0	6	4
428	R:R:K156	R:R:V153	3.04	No	No	0	9	8
429	R:R:M181	R:R:V177	3.04	No	No	0	4	4
430	R:R:T200	S:S:I194	3.04	No	No	0	7	8
431	R:R:I303	R:R:T259	3.04	No	No	0	8	9
432	R:R:M261	R:R:V264	3.04	Yes	No	0	7	8
433	S:S:I194	S:S:T213	3.04	No	No	0	8	5
434	S:S:M199	S:S:V201	3.04	Yes	No	19	7	7
435	S:S:M199	S:S:V206	3.04	Yes	No	19	7	5
436	S:S:I260	S:S:T259	3.04	No	No	0	9	9
437	R:R:L195	R:R:S212	3	No	No	0	7	6
438	S:S:L180	S:S:S125	3	No	No	0	9	8
439	S:S:L172	S:S:S132	3	No	No	0	9	9
440	R:R:L111	R:R:V110	2.98	No	No	0	4	4
441	R:R:L234	S:S:V268	2.98	No	No	0	6	7
442	R:R:L236	R:R:V268	2.98	Yes	No	0	9	7
443	R:R:L273	R:R:V277	2.98	No	No	0	7	8
444	S:S:N255	S:S:S250	2.98	No	Yes	0	9	9
445	R:R:T202	S:S:L192	2.95	No	No	0	5	7
446	S:S:L104	S:S:T122	2.95	Yes	No	0	8	6
447	R:R:D109	R:R:S44	2.94	No	No	0	4	6
448	R:R:I72	R:R:I89	2.94	No	No	0	7	5
449	R:R:I138	R:R:I260	2.94	No	No	0	8	9
450	R:R:I138	R:R:I307	2.94	No	No	0	8	8
451	S:S:I72	S:S:I89	2.94	No	No	0	7	5
452	S:S:I138	S:S:I260	2.94	No	No	0	8	9
453	S:S:I138	S:S:I307	2.94	No	Yes	0	8	8
454	S:S:I303	S:S:I307	2.94	No	Yes	0	8	8
455	S:S:N88	S:S:T71	2.92	No	No	0	9	9
456	R:R:I160	R:R:K147	2.91	No	No	0	9	8
457	S:S:I228	S:S:K232	2.91	No	Yes	0	6	9
458	R:R:Y241	S:S:G244	2.9	Yes	No	0	9	9
459	R:R:M328	R:R:M82	2.89	Yes	No	0	9	9
460	R:R:D205	R:R:T202	2.89	No	No	0	6	5
461	R:R:P335	S:S:F149	2.89	No	No	0	9	9
462	R:R:V201	S:S:Q193	2.87	No	No	0	7	7
463	R:R:I52	R:R:L49	2.85	No	No	0	5	9
464	R:R:I107	R:R:L119	2.85	No	Yes	0	6	6
465	S:S:I89	S:S:L68	2.85	No	No	0	5	6
466	S:S:I129	S:S:L97	2.85	Yes	No	0	7	8
467	S:S:I129	S:S:L133	2.85	Yes	No	17	7	9
468	S:S:I129	S:S:L173	2.85	Yes	No	17	7	7
469	S:S:I129	S:S:L180	2.85	Yes	No	0	7	9
470	S:S:I260	S:S:L139	2.85	No	No	0	9	9
471	S:S:I178	S:S:L179	2.85	No	No	0	6	7
472	R:R:L119	R:R:M116	2.83	Yes	No	0	6	6
473	R:R:L195	S:S:M199	2.83	No	Yes	0	7	7
474	S:S:G272	S:S:W229	2.81	No	Yes	0	7	5
475	R:R:M261	R:R:N265	2.8	Yes	No	0	7	7
476	R:R:L68	R:R:L92	2.77	No	No	0	6	8
477	R:R:L104	R:R:L119	2.77	No	Yes	12	8	6
478	R:R:L139	R:R:L235	2.77	No	No	0	9	8
479	R:R:L139	R:R:L242	2.77	No	No	0	9	9
480	R:R:A317	R:R:F318	2.77	No	Yes	0	7	9
481	S:S:L179	S:S:L227	2.77	No	No	0	7	7
482	R:R:Y241	S:S:A243	2.67	Yes	No	0	9	9
483	R:R:L192	R:R:Q190	2.66	Yes	No	0	7	7
484	S:S:F306	S:S:T259	2.59	Yes	No	0	7	9
485	S:S:F306	S:S:T302	2.59	Yes	No	0	7	8
486	R:R:E321	R:R:Q323	2.55	No	No	0	8	8
487	S:S:S58	S:S:Y103	2.54	No	Yes	0	9	8
488	R:R:Y280	S:S:V223	2.52	No	No	15	7	6
489	S:S:V223	S:S:Y220	2.52	No	No	15	6	8
490	R:R:I159	R:R:R157	2.51	No	No	0	9	9
491	S:S:F56	S:S:I52	2.51	No	No	0	7	5
492	S:S:F318	S:S:N77	2.42	No	No	0	9	9
493	S:S:D187	S:S:R219	2.38	No	No	0	9	3
494	R:R:L227	R:R:W224	2.28	No	Yes	0	7	9
495	S:S:L168	S:S:W143	2.28	No	No	0	7	9
496	R:R:F318	R:R:R327	2.14	Yes	No	0	9	5
497	S:S:F297	S:S:F56	2.14	Yes	No	0	8	7
498	R:R:G130	R:R:G94	2.11	No	Yes	11	9	9
499	R:R:G294	R:R:G295	2.11	No	No	0	9	8
500	S:S:G294	S:S:G295	2.11	No	No	0	9	8
501	S:S:C59	S:S:G60	1.96	No	No	0	4	9
502	R:R:A170	R:R:G167	1.95	No	No	0	8	8
503	R:R:A271	R:R:G272	1.95	No	No	0	7	7
504	S:S:A170	S:S:G167	1.95	No	No	0	8	8
505	R:R:G294	R:R:S293	1.86	No	No	0	9	9
506	R:R:G94	R:R:V134	1.84	Yes	No	0	9	8
507	S:S:G94	S:S:V134	1.84	No	No	0	9	8
508	R:R:A270	R:R:C299	1.81	No	No	0	5	9
509	S:S:A270	S:S:C299	1.81	No	No	0	5	9
510	R:R:A240	S:S:A240	1.79	No	No	0	8	8
511	R:R:P47	R:R:S46	1.78	No	No	0	7	9
512	S:S:P85	S:S:S84	1.78	No	Yes	0	9	9
513	R:R:P47	R:R:V48	1.77	No	No	0	7	8
514	R:R:G94	R:R:L97	1.71	Yes	No	11	9	8
515	R:R:G130	R:R:L97	1.71	No	No	11	9	8
516	R:R:L245	S:S:G247	1.71	No	No	0	9	7
517	S:S:G51	S:S:L50	1.71	No	No	0	8	5
518	S:S:G233	S:S:L236	1.71	No	Yes	0	8	9
519	S:S:G295	S:S:L274	1.71	No	No	0	8	6
520	R:R:A226	S:S:V276	1.7	No	No	0	5	8
521	R:R:V276	S:S:A226	1.7	No	No	0	8	5
522	S:S:C305	S:S:T301	1.69	No	No	0	9	8
523	R:R:C216	R:R:I120	1.64	Yes	No	0	9	6
524	R:R:C216	R:R:I189	1.64	Yes	Yes	1	9	6
525	S:S:L45	S:S:P285	1.64	No	No	0	7	8
526	S:S:C96	S:S:I64	1.64	No	Yes	0	5	5
527	S:S:C305	S:S:I309	1.64	No	No	0	9	8
528	R:R:S196	S:S:S198	1.63	No	No	0	4	7
529	R:R:N286	R:R:P285	1.63	No	No	0	9	8
530	R:R:A240	R:R:M261	1.61	No	Yes	0	8	7
531	S:S:A240	S:S:M261	1.61	No	No	0	8	7
532	R:R:S196	R:R:T211	1.6	No	No	0	4	8
533	R:R:V197	S:S:V197	1.6	No	No	0	8	8
534	R:R:S198	R:R:T209	1.6	No	No	0	7	8
535	R:R:S207	R:R:T200	1.6	No	No	0	7	7
536	R:R:V276	S:S:V223	1.6	No	No	0	8	6
537	R:R:V277	R:R:V288	1.6	No	No	0	8	8
538	R:R:C96	R:R:L61	1.59	No	No	0	5	8
539	R:R:C96	R:R:L93	1.59	No	No	0	5	5
540	R:R:C96	R:R:L97	1.59	No	No	0	5	8
541	R:R:C299	R:R:L266	1.59	No	No	0	9	8
542	R:R:T302	R:R:V298	1.59	No	No	0	8	8
543	S:S:C96	S:S:L93	1.59	No	No	0	5	5
544	S:S:T278	S:S:V277	1.59	No	Yes	0	8	8
545	S:S:T278	S:S:V288	1.59	No	No	0	8	8
546	S:S:T292	S:S:V288	1.59	No	No	0	8	8
547	S:S:T302	S:S:V298	1.59	No	No	0	8	8
548	S:S:P253	S:S:Q314	1.58	Yes	No	0	9	9
549	S:S:T118	S:S:T122	1.57	No	No	0	6	6
550	S:S:T200	S:S:T209	1.57	No	No	0	7	8
551	S:S:I129	S:S:V177	1.54	Yes	No	0	7	4
552	R:R:K330	R:R:S251	1.53	No	No	0	9	8
553	R:R:C191	R:R:E117	1.52	No	No	1	9	6
554	R:R:C216	R:R:E117	1.52	Yes	No	1	9	6
555	S:S:M181	S:S:V177	1.52	No	No	0	4	4
556	S:S:M181	S:S:V184	1.52	No	Yes	0	4	7
557	R:R:L45	R:R:S44	1.5	Yes	No	0	7	6
558	S:S:L62	S:S:S58	1.5	No	No	0	8	9
559	S:S:L195	S:S:S212	1.5	No	No	0	7	6
560	S:S:K204	S:S:T202	1.5	No	No	0	6	5
561	R:R:L166	R:R:V90	1.49	No	No	0	8	9
562	R:R:L173	R:R:V177	1.49	No	No	0	7	4
563	R:R:L185	R:R:V184	1.49	No	No	0	7	7
564	S:S:N286	S:S:S46	1.49	No	No	0	9	9
565	S:S:L166	S:S:V90	1.49	No	No	0	8	9
566	S:S:L145	S:S:V148	1.49	Yes	No	0	9	9
567	S:S:L185	S:S:V184	1.49	No	Yes	0	7	7
568	S:S:L273	S:S:V277	1.49	No	Yes	0	7	8
569	R:R:L104	R:R:T122	1.47	No	No	12	8	6
570	R:R:L119	R:R:T122	1.47	Yes	No	12	6	6
571	R:R:L192	S:S:T202	1.47	Yes	No	0	7	5
572	S:S:C74	S:S:H73	1.47	No	No	0	7	8
573	S:S:C191	S:S:H214	1.47	No	No	0	9	5
574	R:R:I178	R:R:M181	1.46	No	No	0	6	4
575	S:S:D205	S:S:T202	1.45	No	No	0	6	5
576	R:R:Q151	R:R:V153	1.43	No	No	0	9	8
577	S:S:I64	S:S:L65	1.43	Yes	No	0	5	4
578	S:S:G230	S:S:W229	1.41	No	Yes	0	6	5
579	R:R:L62	R:R:L65	1.38	No	No	0	8	4
580	R:R:L65	R:R:L68	1.38	No	No	0	4	6
581	R:R:L165	R:R:L168	1.38	Yes	No	0	9	7
582	R:R:D205	R:R:K204	1.38	No	No	0	6	6
583	R:R:L269	S:S:L234	1.38	No	No	0	5	6
584	R:R:E320	R:R:K316	1.35	No	No	0	8	9
585	S:S:D109	S:S:Q108	1.31	No	No	0	4	6
586	R:R:E320	R:R:E321	1.27	No	No	0	8	8
587	R:R:I72	R:R:R75	1.25	No	No	0	7	8
588	R:R:I325	R:R:R78	1.25	No	No	0	5	9
589	R:R:K76	R:R:R75	1.24	No	No	0	7	8
590	S:S:F66	S:S:L63	1.22	No	No	0	6	8
591	S:S:F66	S:S:L312	1.22	No	No	0	6	8
592	S:S:F306	S:S:L258	1.22	Yes	No	0	7	6
593	R:R:F297	R:R:F56	1.07	Yes	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.56895	19	1	0
2	M:M:?1	6.81	17	2	0
3	R:R:L45	4.6125	4	0	7
4	R:R:I64	6.4275	4	4	5
5	R:R:N77	7.625	4	3	9
6	R:R:I79	6.03	4	3	9
7	R:R:L87	5.5925	4	5	9
8	R:R:N88	5.6675	4	5	9
9	R:R:G94	2.27	4	11	9
10	R:R:S95	6.3125	4	4	9
11	R:R:Y99	5.09714	7	4	9
12	R:R:L119	2.712	5	12	6
13	R:R:P137	4.588	5	0	9
14	R:R:K141	6.425	4	5	9
15	R:R:R144	5.6025	4	0	9
16	R:R:L165	3.4525	4	0	9
17	R:R:D176	6.555	4	13	9
18	R:R:W183	7.82167	6	1	9
19	R:R:D187	5.16	5	1	9
20	R:R:I189	5.2375	4	1	6
21	R:R:L192	3.6775	4	1	7
22	R:R:F215	4.5075	4	1	5
23	R:R:C216	3.02	4	1	9
24	R:R:W224	6.09167	6	1	9
25	R:R:L236	4.555	4	14	9
26	R:R:Y241	5.934	5	0	9
27	R:R:V249	4.415	4	0	9
28	R:R:P253	6.454	5	3	9
29	R:R:M261	4.528	5	0	7
30	R:R:R279	10.465	4	0	6
31	R:R:F289	5.44429	7	10	8
32	R:R:F297	5.13	4	4	8
33	R:R:F308	8.80667	6	5	9
34	R:R:W315	11.4475	4	3	7
35	R:R:F318	5.676	5	3	9
36	R:R:M328	5.6475	4	3	9
37	R:R:Y331	8.57167	6	3	9
38	S:S:I64	3.54667	6	6	5
39	S:S:F70	6.556	5	7	9
40	S:S:S84	4.0875	4	8	9
41	S:S:L87	4.305	4	8	9
42	S:S:Y99	6.815	6	6	9
43	S:S:Y103	5.255	4	0	8
44	S:S:L104	3.755	4	9	8
45	S:S:R123	7.442	5	9	9
46	S:S:I129	2.588	5	17	7
47	S:S:P137	4.968	5	0	9
48	S:S:R144	6.624	5	8	9
49	S:S:L145	4.09	4	18	9
50	S:S:Y146	9.1475	4	0	9
51	S:S:W183	7.18714	7	2	9
52	S:S:V184	4.18	4	2	7
53	S:S:M199	3.4425	4	19	7
54	S:S:D222	9.305	4	0	5
55	S:S:W224	11.3475	4	2	9
56	S:S:W229	5.5	5	2	5
57	S:S:K232	6.81	4	0	9
58	S:S:L236	6.7275	4	2	9
59	S:S:S250	3.89	4	18	9
60	S:S:P253	5.0575	4	0	9
61	S:S:V277	4.495	4	0	8
62	S:S:R279	9.26	4	2	6
63	S:S:F289	5.28571	7	16	8
64	S:S:F297	5.5225	4	6	8
65	S:S:F306	2.91	4	0	7
66	S:S:I307	6.01	4	0	8
67	S:S:F308	8.632	5	0	9
68	S:S:Q311	5.805	4	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R279	100	9.61	Yes	Yes	0	0	6
2	R:R:D222	R:R:R279	33.4077	8.34	No	Yes	0	5	6
3	R:R:D222	S:S:R279	33.1346	13.1	No	Yes	2	5	6
4	M:M:?1	S:S:R279	68.3632	8.24	Yes	Yes	2	0	6
5	R:R:R279	S:S:D222	67.4799	14.29	Yes	Yes	0	6	5
6	S:S:D222	S:S:R279	33.8167	9.53	Yes	Yes	0	5	6
7	S:S:D222	S:S:I225	34.4628	4.2	Yes	No	0	5	7
8	M:M:?1	S:S:I225	33.8013	4.03	Yes	No	2	0	7
9	M:M:?1	S:S:L127	67.4201	4.69	Yes	No	0	0	9
10	M:M:?1	S:S:F215	12.9091	4.13	Yes	No	0	0	5
11	M:M:?1	S:S:L267	23.8836	7.04	Yes	No	2	0	7
12	M:M:?1	S:S:L274	11.6262	3.91	Yes	No	0	0	6
13	L:L:?1	R:R:L127	82.8863	3.91	Yes	No	0	0	9
14	R:R:L127	R:R:S101	80.0403	9.01	No	No	0	9	9
15	R:R:S101	R:R:T98	79.3992	3.2	No	No	0	9	9
16	R:R:T300	R:R:T98	79.1967	7.85	No	No	0	9	9
17	R:R:T300	R:R:Y99	47.0441	9.99	No	Yes	4	9	9
18	R:R:F297	R:R:Y99	11.8493	4.13	Yes	Yes	4	8	9
19	R:R:F297	R:R:L57	11.0036	3.65	Yes	No	0	8	9
20	R:R:S95	R:R:T300	31.9509	3.2	Yes	No	4	9	9
21	R:R:I64	R:R:S95	31.3022	9.29	Yes	Yes	4	5	9
22	R:R:I64	R:R:L92	64.3261	5.71	Yes	No	0	5	8
23	R:R:F308	R:R:L92	61.6971	9.74	Yes	No	0	9	8
24	R:R:I64	R:R:Y99	33.6333	3.63	Yes	Yes	4	5	9
25	R:R:F308	R:R:N88	59.6258	7.25	Yes	Yes	5	9	9
26	R:R:K141	R:R:N88	58.0387	6.99	Yes	Yes	5	9	9
27	R:R:K141	R:R:S84	43.7211	7.65	Yes	No	5	9	9
28	R:R:R144	R:R:S84	43.345	5.27	Yes	No	0	9	9
29	R:R:D162	R:R:R144	41.575	4.76	No	Yes	0	9	9
30	R:R:D162	R:R:N86	40.7105	6.73	No	No	0	9	9
31	R:R:N86	R:R:P85	39.8447	3.26	No	No	0	9	9
32	R:R:P85	R:R:V80	38.9781	3.53	No	No	0	9	9
33	R:R:N77	R:R:V80	38.1106	4.43	Yes	No	0	9	9
34	R:R:I79	R:R:N77	28.5117	4.25	Yes	Yes	3	9	9
35	R:R:I79	R:R:Y331	11.5882	7.25	Yes	Yes	3	9	9
36	R:R:F308	R:R:I307	13.268	11.3	Yes	No	0	9	8
37	R:R:I138	R:R:I307	13.2403	2.94	No	No	0	8	8
38	R:R:I138	R:R:I260	13.233	2.94	No	No	0	8	9
39	S:S:L236	S:S:L267	23.3973	6.92	Yes	No	2	9	7
40	S:S:L236	S:S:V264	23.0443	13.41	Yes	No	0	9	8
41	R:R:L237	S:S:V264	22.8545	4.47	No	No	0	7	8
42	R:R:L237	S:S:L237	22.7135	4.15	No	No	0	7	7
43	R:R:V264	S:S:L237	21.4328	10.43	No	No	14	8	7
44	R:R:M261	R:R:V264	21.7276	3.04	Yes	No	0	7	8
45	S:S:F215	S:S:T213	12.3813	5.19	No	No	0	5	5
46	S:S:I296	S:S:L127	65.0975	7.14	No	No	0	9	9
47	S:S:F105	S:S:I296	10.6805	3.77	No	No	0	9	9
48	S:S:F105	S:S:R123	18.9884	13.9	No	Yes	0	9	9
49	S:S:L274	S:S:T292	10.1314	4.42	No	No	0	6	8
50	R:R:A243	R:R:I260	13.2655	4.87	No	No	0	9	9
51	R:R:A243	R:R:M261	13.3625	3.22	No	Yes	0	9	7
52	S:S:A102	S:S:I296	56.196	4.87	No	No	0	8	9
53	S:S:A102	S:S:L57	55.7208	3.15	No	No	0	8	9
54	S:S:L57	S:S:Y103	12.1416	8.21	No	Yes	0	9	8
55	S:S:W54	S:S:Y103	10.7172	6.75	No	Yes	0	7	8
56	S:S:L50	S:S:W54	10.1609	14.81	No	No	0	5	7
57	S:S:F297	S:S:L57	43.3848	3.65	Yes	No	0	8	9
58	S:S:F297	S:S:Y99	35.5055	7.22	Yes	Yes	6	8	9
59	S:S:I64	S:S:Y99	33.4222	3.63	Yes	Yes	6	5	9
60	S:S:I64	S:S:L92	30.3949	4.28	Yes	No	0	5	8
61	S:S:F308	S:S:L92	28.3095	3.65	Yes	No	0	9	8
62	S:S:F308	S:S:N88	12.1134	7.25	Yes	No	0	9	9
63	S:S:K141	S:S:N88	11.0322	5.6	No	No	0	9	9
64	S:S:K141	S:S:S84	10.6279	6.12	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:?1	S:S:L124	10.95	2	Yes	No	0	5	0	1
M:M:?1	S:S:L127	4.69	2	Yes	No	0	9	0	1
M:M:?1	S:S:C128	4.48	2	Yes	No	0	9	0	1
M:M:?1	S:S:T131	6.66	2	Yes	No	0	8	0	1
M:M:?1	S:S:W183	10.3	2	Yes	Yes	0	9	0	1
M:M:?1	S:S:F215	4.13	2	Yes	No	0	5	0	1
M:M:?1	S:S:A217	4.45	2	Yes	No	0	8	0	1
M:M:?1	S:S:S221	9.33	2	Yes	No	0	8	0	1
M:M:?1	S:S:I225	4.03	2	Yes	No	0	7	0	1
M:M:?1	S:S:W229	8.37	2	Yes	Yes	0	5	0	1
M:M:?1	S:S:K232	9.56	2	Yes	Yes	0	9	0	1
M:M:?1	S:S:L267	7.04	2	Yes	No	0	7	0	1
M:M:?1	S:S:L274	3.91	2	Yes	No	0	6	0	1
M:M:?1	S:S:F275	6.88	2	Yes	No	0	4	0	1
M:M:?1	S:S:T278	9.16	2	Yes	No	0	8	0	1
M:M:?1	S:S:R279	8.24	2	Yes	Yes	0	6	0	1
M:M:?1	S:S:C299	3.59	2	Yes	No	0	9	0	1
R:R:D222	S:S:R279	13.1	2	No	Yes	5	6	2	1
R:R:D222	S:S:Y280	5.75	2	No	No	5	7	2	2
S:S:L127	S:S:S101	7.51	0	No	No	9	9	1	2
S:S:Q121	S:S:W183	3.29	2	No	Yes	9	9	2	1
S:S:Q121	S:S:V184	10.03	2	No	Yes	9	7	2	2
S:S:I189	S:S:Q121	6.86	2	No	No	6	9	2	2
S:S:L124	S:S:W183	3.42	2	No	Yes	5	9	1	1
S:S:I296	S:S:L127	7.14	0	No	No	9	9	2	1
S:S:C128	S:S:L180	3.17	0	No	No	9	9	1	2
S:S:F135	S:S:L236	4.87	2	No	Yes	8	9	2	2
S:S:F135	S:S:L267	3.65	2	No	No	8	7	2	1
S:S:D176	S:S:K232	8.3	0	No	Yes	9	9	2	1
S:S:V184	S:S:W183	3.68	2	Yes	Yes	7	9	2	1
S:S:I189	S:S:W183	4.7	2	No	Yes	6	9	2	1
S:S:S218	S:S:W183	6.18	0	No	Yes	9	9	2	1
S:S:W183	S:S:W224	18.74	2	Yes	Yes	9	9	1	2
S:S:F215	S:S:T213	5.19	0	No	No	5	5	1	2
S:S:D222	S:S:I225	4.2	0	Yes	No	5	7	2	1
S:S:D222	S:S:R279	9.53	0	Yes	Yes	5	6	2	1
S:S:F275	S:S:I225	8.79	2	No	No	4	7	1	1
S:S:A271	S:S:W229	3.89	0	No	Yes	7	5	2	1
S:S:F275	S:S:W229	11.02	2	No	Yes	4	5	1	1
S:S:C231	S:S:K232	6.47	0	No	Yes	6	9	2	1
S:S:L236	S:S:L267	6.92	2	Yes	No	9	7	2	1
S:S:L274	S:S:T292	4.42	0	No	No	6	8	1	2
S:S:R279	S:S:Y280	6.17	2	Yes	No	6	7	1	2
S:S:I228	S:S:K232	2.91	0	No	Yes	6	9	2	1
S:S:G272	S:S:W229	2.81	0	No	Yes	7	5	2	1
S:S:A270	S:S:C299	1.81	0	No	No	5	9	2	1
S:S:G295	S:S:L274	1.71	0	No	No	8	6	2	1
S:S:T278	S:S:V277	1.59	0	No	Yes	8	8	1	2
S:S:T278	S:S:V288	1.59	0	No	No	8	8	1	2
S:S:T292	S:S:V288	1.59	0	No	No	8	8	2	2
S:S:G230	S:S:W229	1.41	0	No	Yes	6	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L124	10.95	1	Yes	No	0	5	0	1
L:L:?1	R:R:L127	3.91	1	Yes	No	0	9	0	1
L:L:?1	R:R:T131	6.66	1	Yes	No	0	8	0	1
L:L:?1	R:R:W183	7.72	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:I189	4.03	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F215	5.5	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:A217	6.23	1	Yes	No	0	8	0	1
L:L:?1	R:R:S221	6.79	1	Yes	No	0	8	0	1
L:L:?1	R:R:I225	5.64	1	Yes	No	0	7	0	1
L:L:?1	R:R:I228	4.03	1	Yes	No	0	6	0	1
L:L:?1	R:R:W229	17.37	1	Yes	No	0	5	0	1
L:L:?1	R:R:K232	5.58	1	Yes	No	0	9	0	1
L:L:?1	R:R:L267	6.26	1	Yes	No	0	7	0	1
L:L:?1	R:R:A271	3.56	1	Yes	No	0	7	0	1
L:L:?1	R:R:L274	4.69	1	Yes	No	0	6	0	1
L:L:?1	R:R:T278	8.33	1	Yes	No	0	8	0	1
L:L:?1	R:R:R279	9.61	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:H282	4.36	1	Yes	No	0	5	0	1
L:L:?1	R:R:C299	3.59	1	Yes	No	0	9	0	1
R:R:L127	R:R:S101	9.01	0	No	No	9	9	1	2
R:R:F105	R:R:L127	3.65	0	No	No	9	9	2	1
R:R:F105	R:R:T292	7.78	0	No	No	9	8	2	2
R:R:Q121	R:R:W183	9.86	1	No	Yes	9	9	2	1
R:R:Q121	R:R:V184	4.3	1	No	No	9	7	2	2
R:R:I189	R:R:Q121	8.23	1	Yes	No	6	9	1	2
R:R:L124	R:R:W183	4.56	1	No	Yes	5	9	1	1
R:R:C128	R:R:K232	3.23	13	No	No	9	9	2	1
R:R:K232	R:R:S132	4.59	0	No	No	9	9	1	2
R:R:F135	R:R:L267	3.65	0	No	No	8	7	2	1
R:R:V184	R:R:W183	3.68	1	No	Yes	7	9	2	1
R:R:I189	R:R:W183	7.05	1	Yes	Yes	6	9	1	1
R:R:W183	R:R:W224	14.06	1	Yes	Yes	9	9	1	2
R:R:I194	R:R:L192	5.71	1	No	Yes	8	7	2	2
R:R:F215	R:R:L192	4.87	1	Yes	Yes	5	7	1	2
R:R:F215	R:R:I194	3.77	1	Yes	No	5	8	1	2
R:R:F215	R:R:T213	3.89	1	Yes	No	5	5	1	2
R:R:S218	R:R:S221	3.26	1	No	No	9	8	2	1
R:R:S218	R:R:W224	3.71	1	No	Yes	9	9	2	2
R:R:D222	R:R:R279	8.34	2	No	Yes	5	6	2	1
R:R:I225	R:R:W229	9.4	1	No	No	7	5	1	1
R:R:F275	R:R:I225	3.77	0	No	No	4	7	2	1
R:R:A271	R:R:W229	3.89	1	No	No	7	5	1	1
R:R:L274	R:R:T292	5.9	0	No	No	6	8	1	2
R:R:F275	R:R:R279	9.62	0	No	Yes	4	6	2	1
R:R:T278	R:R:V288	4.76	0	No	No	8	8	1	2
R:R:R279	S:S:D222	14.29	0	Yes	Yes	6	5	1	2
R:R:A271	R:R:G272	1.95	1	No	No	7	7	1	2
R:R:A270	R:R:C299	1.81	0	No	No	5	9	2	1
R:R:C216	R:R:I189	1.64	1	Yes	Yes	9	6	2	1
R:R:C299	R:R:L266	1.59	0	No	No	9	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IED_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	527
Number of Links	593
Number of Hubs	68
Number of Links mediated by Hubs	290
Number of Communities	19
Number of Nodes involved in Communities	112
Number of Links involved in Communities	142

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	364657
Length Of Smallest Path	3
Average Path Length	21.0927
Length of Longest Path	45
Minimum Path Strength	1.22
Average Path Strength	6.30576
Maximum Path Strength	14.92
Minimum Path Correlation	0.7
Average Path Correlation	0.950396
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	40.8743
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.6306
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8NFN8
Sequence	>8IED_nogp_Chain_R S L S P V L L G I V W T F L S C G L L L I L F F L A F T I H C R K N R I V K M S S P N L N I V T L L G S C L T Y S S A Y L F G I Q D V L S M E T L I Q T R L S M L C I G T S L V F G P I L G K S W R L Y K V F T Q R V P D K R V I I K D L Q L L G L V A A L L M A D V I L L M T W V L T D P I Q C L Q I L S V S M T V T G K D V S C T S T S T H F C A S R Y S D V W I A L I W G C K G L L L L Y G A Y L A G L T G H V S S P P V N Q S L T I M V G V N L L V L A A G L L F V V T R Y L H S W P N L V F G L T S G G I F V C T T T I N C F I F I P Q L K Q W K A F E E E N Q T I R R M A K Y F S T P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	Q8NFN8
Sequence	>8IED_nogp_Chain_S S L S P V L L G I V W T F L S C G L L L I L F F L A F T I H C R K N R I V K M S S P N L N I V T L L G S C L T Y S S A Y L F G I Q D V S S M E T L I Q T R L S M L C I G T S L V F G P I L G K S W R L Y K V F T Q R V P D I I K D L Q L L G L V A A L L M A D V I L L M T W V L T D P I Q C L Q I L S V S M T V T G K D V S C T S T S T H F C A S R Y S D V W I A L I W G C K G L L L L Y G A Y L A G L T G H V S S P P V N Q S L T I M V G V N L L V L A A G L L F V V T R Y L H S W P N L V F G L T S G G I F V C T T T I N C F I F I P Q L K Q W K A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YJP	C	Orphan	Orphan	GPR156	Homo sapiens	-	-	-	3.09	2025-02-05	doi.org/10.1038/s41467-024-54681-5
	8YK0	C	Orphan	Orphan	GPR156	Homo sapiens	-	-	Gi3/β1/γ2	2.4	2025-02-05	doi.org/10.1038/s41467-024-54681-5
	8YK0 (No Gprot)	C	Orphan	Orphan	GPR156	Homo sapiens	-	-		2.4	2025-02-05	doi.org/10.1038/s41467-024-54681-5
	8IEB	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	3.03	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IED	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	Go/β1/γ2	3.33	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IED (No Gprot)	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-		3.33	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IEI	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	2.62	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IEP	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	2.61	2024-02-14	doi.org/10.1038/s41594-024-01224-7

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