Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?402 5.043331810
2H:H:?404 5.4851810
3R:R:L24 6.3425407
4R:R:L27 6.685407
5R:R:I32 3.044565
6R:R:L45 7.885447
7R:R:L50 4.9025445
8R:R:I64 5.576525
9R:R:F67 9.224529
10R:R:N77 4.41409
11R:R:L87 5.4675409
12R:R:L92 7.9428
13R:R:Y99 6.918509
14R:R:Q108 4.25446
15R:R:V134 3.6325408
16R:R:P137 4.592509
17R:R:R144 4.935409
18R:R:Y146 10.6479
19R:R:I160 3.505409
20R:R:D176 6.5075419
21R:R:W183 9.505419
22R:R:D187 4.53489
23R:R:S198 2.43457
24R:R:W224 6.91509
25R:R:K232 4.985419
26R:R:L236 5.04419
27R:R:S250 5.015409
28R:R:R279 9.096516
29R:R:Y280 5.8425417
30R:R:F289 6.158548
31R:R:F308 11.342529
32S:S:I32 4.272595
33S:S:L45 6.0045137
34S:S:L49 3.4325409
35S:S:I64 5.29535
36S:S:F67 7.926509
37S:S:N77 3.6625409
38S:S:L87 6.16409
39S:S:N88 6.05439
40S:S:L92 5.585438
41S:S:G94 2.274149
42S:S:Y99 7.166509
43S:S:Y103 4.955408
44S:S:F105 9.3525409
45S:S:L119 5.0525406
46S:S:I120 4.99406
47S:S:P137 4.942509
48S:S:Y146 9.1425409
49S:S:D176 6.16254159
50S:S:W183 8.982519
51S:S:D187 5.25519
52S:S:M199 6.1075467
53S:S:Y220 5.75418
54S:S:D222 9.7225415
55S:S:W224 9.065419
56S:S:W229 7.3175415
57S:S:P253 6.48754169
58S:S:S257 3.8554109
59S:S:I260 3.81409
60S:S:R279 9.978516
61S:S:F289 6.2045138
62S:S:N304 5.585439
63S:S:F306 5.1525407
64S:S:I307 6.48438
65S:S:F308 8.71571739
66S:S:I309 3.02408
67S:S:W315 4.89407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1H:H:?402 R:R:R279 1007.92YesYes106
2R:R:D222 R:R:R279 48.621210.72NoYes156
3R:R:D222 S:S:R279 47.798415.48NoYes156
4H:H:?404 S:S:R279 98.89726.79YesYes106
5R:R:R279 S:S:D222 47.794813.1YesYes165
6S:S:D222 S:S:R279 48.910410.72YesYes156
7H:H:?404 S:S:L127 76.58493.87YesNo009
8H:H:?404 S:S:F215 12.03966.24YesNo005
9H:H:?402 R:R:V134 92.62233.47YesYes008
10R:R:S95 R:R:V134 65.70123.23NoYes098
11R:R:I64 R:R:S95 64.74796.19YesNo259
12R:R:I64 R:R:Y99 53.20737.25YesYes059
13R:R:L61 R:R:Y99 45.34988.21NoYes089
14R:R:L61 R:R:Y103 44.84667.03NoNo088
15R:R:L57 R:R:Y103 44.3428.21NoNo098
16R:R:L57 R:R:S293 42.81974.5NoNo099
17R:R:S293 R:R:V53 41.28468.08NoNo096
18R:R:F289 R:R:V53 40.77017.87YesNo086
19R:R:F289 R:R:Q108 34.75743.51YesYes486
20R:R:D109 R:R:Q108 33.54123.92NoYes046
21R:R:D109 R:R:T41 32.4645.78NoNo045
22R:R:H214 R:R:T41 31.92326.85NoNo055
23R:R:H214 R:R:Q193 31.381111.13NoNo057
24R:R:Q193 R:R:S38 30.29258.66NoNo076
25R:R:S38 S:S:V201 29.74614.85NoNo067
26S:S:V201 S:S:V206 28.6493.21NoNo075
27R:R:I32 S:S:V206 28.09834.61YesNo055
28R:R:I32 S:S:M199 23.58524.37YesYes657
29R:R:T31 S:S:M199 21.37977.53NoYes077
30R:R:L27 R:R:T31 20.81064.42YesNo077
31R:R:L27 S:S:L24 17.94394.15YesNo077
32R:R:V197 S:S:L24 17.36638.94NoNo087
33R:R:V197 S:S:C28 15.62510.25NoNo089
34S:S:C28 S:S:T31 10.23953.38NoNo097
35R:R:I64 R:R:L92 17.55987.14YesYes258
36R:R:T91 R:R:V134 17.66754.76NoYes098
37R:R:P137 R:R:T91 17.10343.5YesNo099
38R:R:L87 R:R:P137 11.68176.57YesYes099
39H:H:?402 R:R:W183 12.69095.84YesYes109
40H:H:?402 R:R:L267 15.85897.09YesNo107
41R:R:L236 R:R:L267 15.15234.15YesNo197
42R:R:I303 R:R:V134 18.36633.07NoYes088
43R:R:G263 R:R:I303 17.81633.53NoNo078
44R:R:G263 R:R:V262 17.2433.68NoNo078
45R:R:F306 R:R:V262 14.93547.87NoNo078
46R:R:F306 R:R:T259 13.77315.19NoNo079
47R:R:Q256 R:R:T259 13.18984.25NoNo099
48R:R:I138 R:R:Q256 12.60524.12NoNo089
49R:R:I138 R:R:I260 12.01834.42NoNo089
50R:R:A243 R:R:I260 10.25224.87NoNo099
51R:R:L236 R:R:V264 14.65268.94YesNo098
52R:R:V264 S:S:L237 14.62784.47NoNo087
53R:R:L237 S:S:L237 12.12324.15NoNo077
54R:R:L237 S:S:V268 12.8832.98NoNo077
55R:R:L234 S:S:V268 12.65552.98NoNo067
56R:R:L234 S:S:N265 12.23884.12NoNo067
57S:S:M261 S:S:N265 12.03545.61NoNo077
58R:R:Y241 S:S:M261 13.54428.38NoNo097
59S:S:F215 S:S:I194 11.44153.77NoNo058
60R:R:Y241 S:S:S257 11.97943.82NoYes099
61S:S:F105 S:S:L127 75.84648.53YesNo099
62S:S:F105 S:S:I296 73.94773.77YesNo099
63S:S:A102 S:S:I296 73.58064.87NoNo089
64S:S:A102 S:S:L57 73.23414.73NoNo089
65S:S:L57 S:S:S293 12.4284.5NoNo099
66S:S:S293 S:S:V53 10.49969.7NoNo096
67S:S:L57 S:S:Y103 66.20368.21NoYes098
68S:S:L61 S:S:Y103 65.18525.86NoYes088
69S:S:L61 S:S:Y99 64.85998.21NoYes089
70S:S:I64 S:S:Y99 61.59287.25YesYes059
71S:S:I64 S:S:L92 31.22595.71YesYes358
72S:S:F308 S:S:L92 29.16359.74YesYes398
73S:S:F308 S:S:F67 22.695818.22YesYes099
74S:S:I64 S:S:N304 29.21245.66YesYes359
75S:S:F308 S:S:N304 28.88993.62YesYes399
76S:S:F67 S:S:L312 15.19984.87YesNo098
77S:S:F70 S:S:L312 14.12327.31NoNo098
78S:S:F70 S:S:W315 10.88517.02NoYes097
79S:S:F308 S:S:N88 30.04446.04YesYes399
80S:S:K141 S:S:N88 27.95095.6NoYes099
81S:S:K141 S:S:L87 19.4799.87NoYes099
82S:S:L87 S:S:P137 15.18986.57YesYes099
83S:S:P137 S:S:T91 10.8785.25YesNo099
84S:S:L119 S:S:R123 10.33234.86YesNo069
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8YJP
Class C
SubFamily Orphan
Type Orphan
SubType GPR156
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.09
Date 2025-02-05
D.O.I. doi.org/10.1038/s41467-024-54681-5
Net Summary
Imin 3.21
Number of Linked Nodes 561
Number of Links 616
Number of Hubs 67
Number of Links mediated by Hubs 273
Number of Communities 16
Number of Nodes involved in Communities 103
Number of Links involved in Communities 135
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 256031
Length Of Smallest Path 3
Average Path Length 21.2264
Length of Longest Path 61
Minimum Path Strength 1.25
Average Path Strength 6.14814
Maximum Path Strength 16.72
Minimum Path Correlation 0.7
Average Path Correlation 0.953645
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 46.3554
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.9259
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeMW9
PDB ResiduesH:H:?402 H:H:?404
Environment DetailsOpen EMBL-EBI Page
CodeMW9
Name(21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate
Synonyms1-stearoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)
Identifier
FormulaC42 H81 O10 P
Molecular Weight777.06
SMILES
PubChem24779551
Formal Charge0
Total Atoms134
Total Chiral Atoms2
Total Bonds133
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8NFN8
Sequence
>8YJP_Chain_R
RPLHDLCKT TITSSHHSS KTISSLSPV LLGIVWTFL SCGLLLILF 
FLAFTIHCR KNRIVKMSS PNLNIVTLL GSCLTYSSA YLFGIQDVL 
VGSSMETLI QTRLSMLCI GTSLVFGPI LGKSWRLYK VFTQRVPDK 
RVIIKDLQL LGLVAALLM ADVILLMTW VLTDPIQCL QILSVSMTV 
TGKDVSCTS TSTHFCASR YSDVWIALI WGCKGLLLL YGAYLAGLT 
GHVSSPPVN QSLTIMVGV NLLVLAAGL LFVVTRYLH SWPNLVFGL 
TSGGIFVCT TTINCFIFI PQLKQWKAF E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ8NFN8
Sequence
>8YJP_Chain_S
RPLHDLCKT TITSSHHSS KTISSLSPV LLGIVWTFL SCGLLLILF 
FLAFTIHCR KNRIVKMSS PNLNIVTLL GSCLTYSSA YLFGIQDVL 
VGSSMETLI QTRLSMLCI GTSLVFGPI LGKSWRLYK VFTQRVPDK 
RVIIKDLQL LGLVAALLM ADVILLMTW VLTDPIQCL QILSVSMTV 
TGKDVSCTS TSTHFCASR YSDVWIALI WGCKGLLLL YGAYLAGLT 
GHVSSPPVN QSLTIMVGV NLLVLAAGL LFVVTRYLH SWPNLVFGL 
TSGGIFVCT TTINCFIFI PQLKQWKAF E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YJPCOrphanOrphanGPR156Homo sapiens---3.092025-02-05doi.org/10.1038/s41467-024-54681-5
8YK0COrphanOrphanGPR156Homo sapiens--Gi3/β1/γ22.42025-02-05doi.org/10.1038/s41467-024-54681-5
8YK0 (No Gprot) COrphanOrphanGPR156Homo sapiens--2.42025-02-05doi.org/10.1038/s41467-024-54681-5
8IEBCOrphanOrphanGPR156Homo sapiensA1LYA--3.032024-02-14doi.org/10.1038/s41594-024-01224-7
8IEDCOrphanOrphanGPR156Homo sapiensA1LYA-Go/β1/γ23.332024-02-14doi.org/10.1038/s41594-024-01224-7
8IED (No Gprot) COrphanOrphanGPR156Homo sapiensA1LYA-3.332024-02-14doi.org/10.1038/s41594-024-01224-7
8IEICOrphanOrphanGPR156Homo sapiensA1LYA--2.622024-02-14doi.org/10.1038/s41594-024-01224-7
8IEPCOrphanOrphanGPR156Homo sapiensA1LYA--2.612024-02-14doi.org/10.1038/s41594-024-01224-7




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8YJP.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.