Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I69 2.17414
2R:R:L70 4.435414
3R:R:V78 5.41415
4R:R:D81 10.4675416
5R:R:Y85 7.78618
6R:R:Y87 5.9425416
7R:R:D90 3.25286717
8R:R:Q93 9.44414
9R:R:L94 3.8325419
10R:R:R102 3.6625415
11R:R:L108 7.2375414
12R:R:W112 7.856514
13R:R:H119 4.515414
14R:R:L122 3.735417
15R:R:D127 2.935265
16R:R:H131 5.594267
17R:R:F135 5.03408
18R:R:V138 2.1975406
19R:R:M139 3.098587
20R:R:L140 3.63254278
21R:R:S145 3.865489
22R:R:W156 4.85409
23R:R:Y157 8.5625489
24R:R:L160 2.43489
25R:R:L165 3.3175416
26R:R:E166 3.075418
27R:R:E168 5.882518
28R:R:I171 3.1325418
29R:R:I176 2.5725487
30R:R:F178 5.304586
31R:R:R196 2.7675418
32R:R:L270 4.08419
33R:R:Y277 7.295188
34R:R:W281 5.268519
35R:R:T284 3.125118
36R:R:L285 3.54519
37R:R:I289 2.86408
38R:R:G302 2.71754119
39R:R:M304 2.205407
40R:R:K305 3.4454118
41R:R:V306 2.72517
42R:R:D307 4.324119
43R:R:I308 1.758516
44R:R:L310 3.116518
45R:R:Q311 3.104519
46R:R:D314 5.378518
47R:R:I315 3.73571718
48R:R:D316 3.74167618
49R:R:Q317 5.518519
50R:R:C318 5.5125419
51R:R:S319 3.67417
52R:R:W323 5.30857719
53R:R:S325 4.784517
54R:R:K329 3.09833615
55R:R:L332 7.3875416
56R:R:N333 7.445419
57R:R:C337 8.635419
58R:R:M338 3.906513
59R:R:I340 7.545415
60R:R:K341 17.045613
61R:R:G344 3.942519
62R:R:V346 9.505417
63R:R:L347 3.885419
64R:R:Y350 7.45143719
65R:R:E351 6.04814
66R:R:C354 4.792519
67R:R:K355 3.24616
68R:R:F358 4.455417
69R:R:P361 4405
70R:R:P365 7.556513
71R:R:R370 12.0711911
72R:R:R372 9.091111
73R:R:D375 6.745411
74R:R:Q376 6.454513
75R:R:H377 11.6871713
76R:R:I378 3.3975401
77R:R:S379 2.505403
78R:R:G380 3.2375413
79R:R:T382 4.4825414
80R:R:V391 3.776513
81R:R:C392 4.6875419
82R:R:L393 2.7525416
83R:R:P394 3.79619
84R:R:C399 4.99754229
85R:R:D405 4.2975407
86R:R:D413 2.5054168
87R:R:R417 9.025169
88R:R:I420 6.665408
89R:R:Q424 6.308529
90R:R:D431 2.765426
91R:R:S446 2.5175428
92R:R:I447 2.56429
93R:R:S450 3.94529
94R:R:I458 3.355429
95R:R:L459 2.395629
96R:R:S462 2.78529
97R:R:Y466 4.59429728
98R:R:F467 3.2125427
99R:R:V469 3.146529
100R:R:Y473 6.6225408
101R:R:P476 1.69254319
102R:R:I482 2.075637
103R:R:R485 6.48409
104R:R:L490 2.344538
105R:R:F492 11.516529
106R:R:V495 4.4175428
107R:R:Y496 8.135629
108R:R:T498 3.755429
109R:R:V499 3.06427
110R:R:T500 3.4225497
111R:R:K502 4.584529
112R:R:H504 5.0075499
113R:R:R517 7.91754179
114R:R:P519 4.3654179
115R:R:Y520 5.04667698
116R:R:R525 7.3825496
117R:R:V526 3.82408
118R:R:M527 1.844307
119R:R:L530 2.1025409
120R:R:L534 2.73436
121R:R:V537 1.555439
122R:R:W539 3.506539
123R:R:F540 2.9025839
124R:R:L541 5.408539
125R:R:W544 5.22333639
126R:R:W578 4.51286739
127R:R:D579 4.555429
128R:R:M581 3.448539
129R:R:F589 2.395498
130R:R:W592 4.736599
131R:R:L596 3.77333699
132R:R:V603 3.7275409
133R:R:E609 3.96333629
134R:R:M613 5.182527
135R:R:N619 3.1775429
136R:R:E620 7.538529
137R:R:L621 2.93254337
138R:R:I623 3.6425
139R:R:F627 11.244529
140R:R:H628 5.742528
141R:R:F632 5.56833629
142R:R:D641 6.784169
143R:R:Y647 3.9275825
144R:R:F648 7.546529
145R:R:H650 8.972529
146R:R:T651 1.93167628
147R:R:H652 8.685629
148R:R:T654 3.82167629
149R:R:V655 2.674527
150R:R:T658 3.074529
151R:R:I659 3.4875427
152R:R:L662 2.5125428
153R:R:K666 3.75529
154S:S:Y85 4.63333678
155S:S:Y87 5.6285146
156S:S:G89 4.31754147
157S:S:D90 3.936676147
158S:S:K95 8.9625472
159S:S:G101 2.23574
160S:S:R102 5.458575
161S:S:L105 4.6405
162S:S:A106 3.27254123
163S:S:G107 2.47754125
164S:S:L108 2.44444
165S:S:W112 10.5565124
166S:S:H119 2.49504
167S:S:L122 2.4245127
168S:S:L126 3.1425404
169S:S:L129 2.15254106
170S:S:T133 1.53754108
171S:S:F135 4.335408
172S:S:M139 4.7254217
173S:S:L150 4.374205
174S:S:D152 3.98254206
175S:S:D155 3.1625487
176S:S:W156 3.6875489
177S:S:Q158 3.0475488
178S:S:V161 2.63754109
179S:S:L165 3.464106
180S:S:E168 4.61754108
181S:S:I171 5.58254108
182S:S:S172 3.6725475
183S:S:I176 3.7954107
184S:S:F178 4.324506
185S:S:P188 1.70754238
186S:S:Q189 3.7165236
187S:S:L270 5.4675479
188S:S:Y277 8.10833678
189S:S:P279 3.568579
190S:S:G280 3.2225473
191S:S:W281 8.21286779
192S:S:L285 6.314109
193S:S:S287 1.84254107
194S:S:I289 2.894158
195S:S:F300 4.1525158
196S:S:G302 3.0054159
197S:S:V303 2.8865159
198S:S:D307 4.985479
199S:S:I308 2.6575406
200S:S:L310 4.2445128
201S:S:D314 7.2448
202S:S:Q317 5.33449
203S:S:W323 8.636129
204S:S:S325 5.58407
205S:S:G326 3.5446
206S:S:H328 4.49549
207S:S:K329 3.85745
208S:S:L332 3.5454196
209S:S:N333 9.07649
210S:S:N334 8.716547
211S:S:C337 8.08449
212S:S:V346 9.992547
213S:S:Y350 5.47286749
214S:S:E351 12.2825444
215S:S:F358 8.045407
216S:S:P361 6.1575445
217S:S:V363 4.0975442
218S:S:P365 7.632543
219S:S:R370 11.5071741
220S:S:R372 10.0483641
221S:S:D375 8.178541
222S:S:Q376 5.3225443
223S:S:H377 15.49543
224S:S:I378 6.184241
225S:S:Y390 4.6285195
226S:S:L393 2.856506
227S:S:P394 5.4285249
228S:S:C395 6.9954249
229S:S:D405 6.47254257
230S:S:C408 3.64259
231S:S:R417 9.258559
232S:S:I420 3.712558
233S:S:Q424 6.366559
234S:S:D431 6.255466
235S:S:S450 3.615669
236S:S:L454 4.7025469
237S:S:I458 2.384569
238S:S:L459 2.21857769
239S:S:S462 3.3825469
240S:S:Y466 5.55167658
241S:S:F467 3.85457
242S:S:V469 3.718559
243S:S:I482 1.88537
244S:S:L489 3.8175437
245S:S:L490 2.23833638
246S:S:V495 4.3975468
247S:S:Y496 11.296569
248S:S:T498 2.62469
249S:S:V499 1.5375467
250S:S:T500 3.294137
251S:S:K502 4.284569
252S:S:H504 4.6854139
253S:S:F510 4.41409
254S:S:R517 5.614179
255S:S:P519 3.47254179
256S:S:Y520 6.6185138
257S:S:G523 1.856568
258S:S:V526 3.4475468
259S:S:M527 1.5475467
260S:S:L530 2.1025409
261S:S:L534 2.36436
262S:S:V537 1.965439
263S:S:W539 3.738539
264S:S:F540 3.18875839
265S:S:L541 5.408539
266S:S:W544 4.42833639
267S:S:V548 1.55436
268S:S:C549 1.6575437
269S:S:L558 3.2525406
270S:S:G562 1.694377
271S:S:I575 5.2675456
272S:S:W578 4.72739
273S:S:D579 4.8525459
274S:S:M581 3.68539
275S:S:E586 8.6975459
276S:S:F589 2.6554138
277S:S:L590 1.66409
278S:S:W592 4.7525139
279S:S:L596 3.501676139
280S:S:V603 4.345409
281S:S:E609 3.72333669
282S:S:P610 2.58409
283S:S:Y612 9.78754419
284S:S:M613 3.964567
285S:S:N619 1.775409
286S:S:E620 7.898569
287S:S:F627 12.122559
288S:S:H628 5.81167658
289S:S:R631 5.798559
290S:S:F632 6.315659
291S:S:D641 6.626559
292S:S:L644 2.95459
293S:S:Y647 3.64875855
294S:S:F648 7.018559
295S:S:T651 2.16658
296S:S:H652 8.46167659
297S:S:T654 3.83833669
298S:S:V655 3.4375407
299S:S:T658 3.11569
300S:S:L662 2.5125468
301S:S:L663 2.4525468
302S:S:K666 5.092569
303S:S:F667 2.414568
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D316 R:R:W323 19.02155.58YesYes189
2R:R:W112 R:R:W323 18.3033.75YesYes149
3R:R:W112 R:R:W265 17.380213.12YesNo147
4R:R:F358 R:R:I315 46.34215.02YesYes178
5R:R:F358 R:R:L310 44.21842.44YesYes178
6R:R:I308 R:R:L310 87.75041.43YesYes168
7R:R:I308 R:R:L285 17.31082.85YesYes169
8R:R:L285 R:R:W265 17.26829.11YesNo197
9R:R:I315 R:R:Y350 50.05052.42YesYes189
10R:R:D314 R:R:Y350 44.34965.75YesYes189
11R:R:D314 R:R:V313 43.93711.46YesNo186
12R:R:L310 R:R:V313 43.89214.47YesNo186
13R:R:E168 R:R:I171 46.74852.73YesYes188
14R:R:I171 R:R:V306 56.15564.61YesYes187
15R:R:I308 R:R:V306 70.37731.54YesYes167
16R:R:E168 R:R:R124 46.27646.98YesNo085
17R:R:R124 S:S:D127 46.15872.38NoNo055
18R:R:L129 R:R:L285 27.86751.38NoYes169
19R:R:L129 R:R:V306 13.98822.98NoYes167
20R:R:L129 R:R:M304 41.49652.83NoYes067
21S:S:D127 S:S:L126 45.68628.14NoYes054
22S:S:L126 S:S:L285 43.65791.38YesYes049
23S:S:L285 S:S:V306 42.10431.49YesNo1097
24S:S:I171 S:S:V306 42.14753.07YesNo1087
25R:R:L160 S:S:F135 21.93342.44YesYes098
26R:R:I176 R:R:L160 22.22081.43YesYes879
27R:R:I176 R:R:M304 28.26631.46YesYes077
28R:R:I289 R:R:M304 11.44661.46YesYes087
29R:R:W156 S:S:F135 19.145.01YesYes098
30R:R:W156 S:S:Y157 16.80434.82YesNo099
31R:R:D316 R:R:S320 20.76681.47YesNo184
32R:R:Q317 R:R:Y350 95.68947.89YesYes199
33R:R:Q317 R:R:S320 10.43464.33YesNo194
34R:R:S319 R:R:S320 10.44221.63YesNo174
35R:R:E351 R:R:Q317 1001.27YesYes149
36R:R:E351 R:R:S319 10.49061.44YesYes147
37R:R:E351 R:R:V346 10015.69YesYes147
38R:R:R370 R:R:V346 10010.46YesYes117
39R:R:I340 R:R:R370 38.98892.51YesYes151
40R:R:R370 R:R:R372 78.10929.6YesYes111
41R:R:I340 R:R:Q376 38.98499.61YesYes153
42R:R:Q376 R:R:R372 39.24038.18YesYes131
43R:R:I378 R:R:R372 39.25415.01YesYes011
44R:R:Q376 R:R:R396 78.574510.51YesNo035
45R:R:I378 R:R:R396 39.83733.76YesNo015
46R:R:E397 R:R:R396 1008.14NoNo065
47R:R:D405 R:R:E397 10012.99YesNo076
48R:R:D405 R:R:F409 1001.19YesNo073
49R:R:F409 R:R:V410 1002.62NoNo036
50R:R:Q639 R:R:V410 1001.43NoNo096
51R:R:D641 R:R:Q639 1001.31YesNo099
52R:R:D641 R:R:R417 10016.68YesYes1699
53R:R:R417 R:R:Y473 1002.06YesYes098
54R:R:I421 R:R:Y473 48.934510.88NoYes078
55R:R:I421 R:R:V469 48.93061.54NoYes079
56R:R:T651 R:R:V469 14.30131.59YesYes289
57R:R:V469 R:R:Y647 34.54951.26YesYes295
58R:R:F474 R:R:Y473 68.511112.38NoYes088
59R:R:F474 R:R:R480 67.82673.21NoNo089
60R:R:R480 R:R:S477 34.42913.95NoNo099
61R:R:S477 R:R:T478 34.39841.6NoNo096
62R:R:I482 R:R:T478 34.17361.52YesNo076
63R:R:I471 R:R:R480 33.37871.25NoNo099
64R:R:L484 R:R:Y647 33.42192.34NoYes095
65R:R:I471 R:R:L484 33.29252.85NoNo099
66R:R:L484 R:R:R485 66.63032.43NoYes099
67R:R:R485 R:R:W544 66.55269YesYes099
68R:R:I482 R:R:W544 33.24292.35YesYes379
69R:R:F540 R:R:W544 37.33523.01YesYes399
70R:R:W544 R:R:W578 62.33515.62YesYes399
71R:R:W578 S:S:F540 61.56252YesYes399
72R:R:F540 S:S:W578 36.94762YesYes399
73S:S:W544 S:S:W578 35.27673.75YesYes399
74S:S:I482 S:S:W544 13.63542.35YesYes379
75S:S:F540 S:S:W544 34.89433.01YesYes399
76S:S:I171 S:S:R196 41.38831.25YesNo088
77S:S:R196 S:S:T195 41.02712.59NoNo088
78S:S:S172 S:S:T195 40.78964.8YesNo058
79S:S:L282 S:S:S172 33.97413NoYes775
80S:S:L282 S:S:P279 33.85711.64NoYes779
81S:S:G280 S:S:P279 26.08042.03YesYes739
82S:S:G280 S:S:W281 19.01354.22YesYes739
83S:S:W281 S:S:Y85 11.96595.79YesYes798
84S:S:F358 S:S:Q311 12.67813.51YesNo079
85S:S:F358 S:S:L310 17.93866.09YesYes078
86S:S:F178 S:S:Y157 14.929212.38YesNo069
87S:S:D576 S:S:W544 27.28087.82NoYes089
88S:S:R485 S:S:W544 27.28436NoYes099
89S:S:D579 S:S:R485 23.768914.29YesNo099
90S:S:D579 S:S:I575 18.05011.4YesYes596
91S:S:I575 S:S:R631 17.17621.25YesYes569
92S:S:R631 S:S:Y647 29.06497.2YesYes595
93S:S:L472 S:S:Y647 11.47284.69NoYes575
94S:S:L472 S:S:L644 10.5914.15NoYes579
95S:S:D576 S:S:D579 23.78041.33NoYes089
96S:S:D579 S:S:F632 29.06092.39YesYes599
97S:S:F632 S:S:R631 17.173510.69YesYes599
98S:S:F540 S:S:L541 22.95922.44YesYes399
99S:S:L490 S:S:L541 18.51931.38YesYes389
100S:S:F632 S:S:H628 10.57944.53YesYes598
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9VOR
Class C
SubFamily Orphan
Type Orphan
SubType GPR158; GPR158
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.47
Date 2025-12-31
D.O.I. To be published
Net Summary
Imin 1.25
Number of Linked Nodes 1010
Number of Links 1460
Number of Hubs 303
Number of Links mediated by Hubs 1027
Number of Communities 41
Number of Nodes involved in Communities 487
Number of Links involved in Communities 761
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 20937301
Length Of Smallest Path 3
Average Path Length 63.3371
Length of Longest Path 76
Minimum Path Strength 1.18
Average Path Strength 6.87954
Maximum Path Strength 23.175
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 56.0007
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 79.465
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ5T848
Sequence
>9VOR_Chain_R
DGTILAQKL AEEVPMDVA SYLYTGDSH QLKRANCSG RYELAGLPG 
KWPALASAH PSLHRALDT LTHATNFLN VMLQSNKSR EQNLQDDLD 
WYQALVWSL LEGEPSISR AAITFSTAP QVFLQATRE ESRILLQDD 
KSHFKWSPP YLECENGSY KPGWLVTLS SAIYGLPEF RGVMKVDIN 
LQKVDIDQC SSDGWFSGT HKCHLNNSE CMPIKGLGF VLGAYECIC 
KAGFYHPGV LPVNNFRRR GPDQHISGS TKDVSEEAY VCLPCREGC 
PFCADDSPC FVQEDKYLR LAIISFQAL CMLLDFVSM LVVYHFRKA 
KSIRASGLI LLETILFGS LLLYFPVVI LYFEPSTFR CILLRWARL 
LGFATVYGT VTLKLHRVL KVFLSRTAQ RIPYMTGGR VMRMLAVIL 
LVVFWFLIG WTSSVCQNL EKQISLIGQ GKTSDHLIF NMCLIDRWD 
YMTAVAEFL FLLWGVYLC YAVRTVPSA FHEPRYMAV AVHNELIIS 
AIFHTIRFV LASRLQSDW MLMLYFAHT HLTVTVTIG LLLIPKFSH 
S


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ5T848
Sequence
>9VOR_Chain_S
DGTILAQKL AEEVPMDVA SYLYTGDSH QLKRANCSG RYELAGLPG 
KWPALASAH PSLHRALDT LTHATNFLN VMLQSNKSR EQNLQDDLD 
WYQALVWSL LEGEPSISR AAITFSTAP QVFLQATRE ESRILLQDS 
HFKWSPPYL ECENGSYKP GWLVTLSSA IYGLQPEFR GVMKVDINL 
QKVDIDQCS SDGWFSGTH KCHLNNSEC MPIKGLGFV LGAYECICK 
AGFYHPGVL PVNNFRRRG PDQHISGST KDVSEEAYV CLPCREGCP 
FCADDSPCF VQEDKYLRL AIISFQALC MLLDFVSML VVYHFRKAK 
SIRASGLIL LETILFGSL LLYFPVVIL YFEPSTFRC ILLRWARLL 
GFATVYGTV TLKLHRVLK VFLSRTAQR IPYMTGGRV MRMLAVILL 
VVFWFLIGW TSSVCQNLE KQISLIGQG KTSDHLIFN MCLIDRWDY 
MTAVAEFLF LLWGVYLCY AVRTVPSAF HEPRYMAVA VHNELIISA 
IFHTIRFVL ASRLQSDWM LMLYFAHTH LTVTVTIGL LLIPKFSHS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EWLCOrphanOrphanGPR158; GPR158Homo sapiens---3.522021-12-01doi.org/10.1038/s41467-021-27147-1
7EWPCOrphanOrphanGPR158; GPR158Homo sapiens--B5; RGS74.32021-12-01doi.org/10.1038/s41467-021-27147-1
7EWRCOrphanOrphanGPR158; GPR158Homo sapiens--B5; RGS74.72021-12-01doi.org/10.1038/s41467-021-27147-1
7SHECOrphanOrphanGPR158; GPR158Homo sapiens---3.42021-12-01doi.org/10.1126/science.abl4732
7SHFCOrphanOrphanGPR158; GPR158Homo sapiens--B5; RGS73.42021-12-01doi.org/10.1126/science.abl4732
9VORCOrphanOrphanGPR158; GPR158Homo sapiens---3.472025-12-31To be published




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Download 9VOR.zip



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