psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:W72	R:R:K187	25.53	No	No	0	0	4
2	L:L:P75	L:L:V74	3.53	Yes	No	0	0	0
3	L:L:V74	R:R:K92	4.55	No	Yes	0	0	5
4	L:L:P75	L:L:Q80	7.9	Yes	No	0	0	0
5	L:L:P75	R:R:R172	10.09	Yes	Yes	0	0	5
6	L:L:A77	R:R:Y40	4	No	Yes	0	0	7
7	L:L:A77	R:R:W89	5.19	No	Yes	0	0	6
8	L:L:L78	L:L:P79	4.93	No	No	0	0	0
9	L:L:L78	R:R:F257	10.96	No	Yes	0	0	7
10	L:L:L78	R:R:A291	4.73	No	No	0	0	8
11	L:L:P79	R:R:S114	7.13	No	No	0	0	5
12	L:L:P79	R:R:M117	6.71	No	No	0	0	7
13	L:L:Q80	R:R:M284	13.59	No	Yes	0	0	4
14	R:R:F35	R:R:V38	7.87	No	No	0	4	5
15	R:R:L36	R:R:P37	3.28	No	Yes	0	5	5
16	R:R:L36	R:R:P289	8.21	No	No	0	5	5
17	R:R:P37	R:R:Y40	4.17	Yes	Yes	0	5	7
18	R:R:E93	R:R:P37	4.72	No	Yes	0	4	5
19	R:R:F39	R:R:V38	3.93	No	No	0	5	5
20	R:R:L86	R:R:Y40	4.69	No	Yes	0	8	7
21	R:R:P289	R:R:Y40	8.34	No	Yes	0	5	7
22	R:R:T41	R:R:V90	3.17	No	No	0	4	6
23	R:R:F292	R:R:V43	3.93	No	No	0	7	7
24	R:R:C296	R:R:V43	3.42	No	No	0	8	7
25	R:R:F44	R:R:L45	3.65	Yes	No	0	7	4
26	R:R:F44	R:R:V48	3.93	Yes	No	0	7	7
27	R:R:F44	R:R:L86	8.53	Yes	No	0	7	8
28	R:R:F44	R:R:P87	17.34	Yes	No	0	7	8
29	R:R:G47	R:R:T46	3.64	No	No	0	8	5
30	R:R:G50	R:R:L49	5.13	No	No	0	7	4
31	R:R:D79	R:R:N51	8.08	Yes	No	0	9	9
32	R:R:N51	R:R:P299	6.52	No	No	0	9	9
33	R:R:I72	R:R:L54	4.28	Yes	No	0	8	9
34	R:R:A76	R:R:L54	3.15	No	No	0	8	9
35	R:R:A76	R:R:M55	3.22	No	Yes	0	8	7
36	R:R:F80	R:R:M55	4.98	No	Yes	0	7	7
37	R:R:A57	R:R:I313	4.87	No	No	0	7	7
38	R:R:D69	R:R:L58	12.21	Yes	No	0	8	7
39	R:R:I309	R:R:L58	7.14	Yes	No	0	8	7
40	R:R:A312	R:R:L58	4.73	No	No	0	6	7
41	R:R:F60	R:R:H59	3.39	No	No	0	5	4
42	R:R:H59	R:R:R65	3.39	No	Yes	0	4	7
43	R:R:K61	R:R:P62	3.35	No	No	0	5	5
44	R:R:K61	R:R:Y308	5.97	No	No	0	5	6
45	R:R:A312	R:R:K61	4.82	No	No	0	6	5
46	R:R:D69	R:R:R65	15.48	Yes	Yes	0	8	7
47	R:R:I70	R:R:R65	3.76	No	Yes	0	6	7
48	R:R:I73	R:R:R65	5.01	No	Yes	0	6	7
49	R:R:I68	R:R:R66	6.26	No	Yes	0	8	7
50	R:R:D69	R:R:R66	4.76	Yes	Yes	0	8	7
51	R:R:R66	R:R:Y308	18.52	Yes	No	0	7	6
52	R:R:I309	R:R:R66	8.77	Yes	Yes	0	8	7
53	R:R:D130	R:R:L67	5.43	Yes	No	5	8	5
54	R:R:L67	R:R:R145	7.29	No	Yes	5	5	7
55	R:R:D130	R:R:I68	5.6	Yes	No	0	8	8
56	R:R:D69	R:R:I72	4.2	Yes	Yes	0	8	8
57	R:R:A150	R:R:I70	4.87	No	No	0	8	6
58	R:R:I70	R:R:Y151	10.88	No	No	0	6	4
59	R:R:C126	R:R:F71	12.57	No	No	0	7	7
60	R:R:F71	R:R:M127	6.22	No	No	0	7	9
61	R:R:D130	R:R:F71	8.36	Yes	No	0	8	7
62	R:R:I72	R:R:Y302	7.25	Yes	Yes	3	8	9
63	R:R:I309	R:R:I72	4.42	Yes	Yes	3	8	8
64	R:R:C154	R:R:N74	9.45	No	No	0	7	9
65	R:R:N74	R:R:W158	3.39	No	Yes	0	9	9
66	R:R:D79	R:R:L75	6.79	Yes	No	0	9	9
67	R:R:L123	R:R:L75	5.54	Yes	No	0	8	9
68	R:R:C119	R:R:S78	6.89	Yes	No	6	7	8
69	R:R:S120	R:R:S78	4.89	No	No	0	9	8
70	R:R:S78	R:R:W158	4.94	No	Yes	6	8	9
71	R:R:D79	R:R:S120	4.42	Yes	No	0	9	9
72	R:R:D79	R:R:S295	11.78	Yes	No	0	9	9
73	R:R:I81	R:R:N116	9.91	No	No	0	7	8
74	R:R:I81	R:R:W158	4.7	No	Yes	0	7	9
75	R:R:F82	R:R:I113	3.77	No	No	0	6	7
76	R:R:F82	R:R:N116	7.25	No	No	0	6	8
77	R:R:F292	R:R:F82	12.86	No	No	0	7	6
78	R:R:S109	R:R:T85	6.4	No	No	0	5	7
79	R:R:F292	R:R:L86	3.65	No	No	0	7	8
80	R:R:K92	R:R:W89	5.8	Yes	Yes	2	5	6
81	R:R:W89	R:R:W99	3.75	Yes	Yes	2	6	8
82	R:R:S109	R:R:W89	7.41	No	Yes	0	5	6
83	R:R:E93	R:R:K92	4.05	No	Yes	0	4	5
84	R:R:K92	R:R:W99	6.96	Yes	Yes	2	5	8
85	R:R:E93	R:R:G97	3.27	No	No	0	4	4
86	R:R:L98	R:R:Y182	5.86	No	Yes	0	4	3
87	R:R:T101	R:R:W99	9.7	Yes	Yes	0	7	8
88	R:R:C106	R:R:W99	6.53	No	Yes	2	9	8
89	R:R:L174	R:R:W99	3.42	Yes	Yes	2	5	8
90	R:R:C183	R:R:W99	6.53	No	Yes	2	9	8
91	R:R:G102	R:R:T101	3.64	No	Yes	0	7	7
92	R:R:L105	R:R:T101	13.27	No	Yes	0	6	7
93	R:R:C106	R:R:L174	7.94	No	Yes	2	9	5
94	R:R:C106	R:R:C183	7.28	No	No	2	9	9
95	R:R:R172	R:R:S110	14.5	Yes	No	0	5	5
96	R:R:L166	R:R:Y111	3.52	No	Yes	0	4	6
97	R:R:L169	R:R:Y111	11.72	No	Yes	0	5	6
98	R:R:H118	R:R:S114	6.97	Yes	No	0	6	5
99	R:R:S114	R:R:T168	9.59	No	No	0	5	4
100	R:R:N116	R:R:V115	4.43	No	No	0	8	6
101	R:R:S161	R:R:V115	4.85	No	No	0	8	6
102	R:R:C162	R:R:V115	3.42	No	No	0	4	6
103	R:R:H118	R:R:M117	7.88	Yes	No	0	6	7
104	R:R:M117	R:R:W254	4.65	No	Yes	0	7	9
105	R:R:H118	R:R:L164	6.43	Yes	No	0	6	4
106	R:R:H118	R:R:T203	4.11	Yes	No	0	6	6
107	R:R:C119	R:R:L123	3.17	Yes	Yes	0	7	8
108	R:R:C119	R:R:W158	14.37	Yes	Yes	6	7	9
109	R:R:C119	R:R:S161	3.44	Yes	No	0	7	8
110	R:R:V121	R:R:W254	4.9	No	Yes	0	8	9
111	R:R:I157	R:R:L122	7.14	Yes	No	0	7	5
112	R:R:C126	R:R:L123	3.17	No	Yes	0	7	8
113	R:R:I157	R:R:L123	5.71	Yes	Yes	0	7	8
114	R:R:I211	R:R:L124	4.28	Yes	No	1	8	8
115	R:R:F250	R:R:L124	4.87	Yes	No	1	9	8
116	R:R:L124	R:R:N294	4.12	No	Yes	1	8	9
117	R:R:P207	R:R:T125	5.25	No	No	0	9	8
118	R:R:S210	R:R:T125	3.2	No	No	0	7	8
119	R:R:M127	R:R:R131	3.72	No	No	0	9	9
120	R:R:M127	R:R:Y302	4.79	No	Yes	0	9	9
121	R:R:I211	R:R:S128	7.74	Yes	No	1	8	9
122	R:R:C214	R:R:S128	5.16	No	No	0	8	9
123	R:R:S128	R:R:Y215	12.72	No	Yes	1	9	9
124	R:R:D130	R:R:R145	4.76	Yes	Yes	5	8	7
125	R:R:R131	R:R:Y215	9.26	No	Yes	0	9	9
126	R:R:V136	R:R:Y132	10.09	Yes	Yes	4	7	8
127	R:R:W137	R:R:Y132	8.68	No	Yes	4	6	8
128	R:R:C214	R:R:Y132	6.72	No	Yes	0	8	8
129	R:R:C217	R:R:Y132	8.06	No	Yes	4	4	8
130	R:R:L133	R:R:S141	7.51	No	No	0	6	5
131	R:R:A134	R:R:R145	5.53	No	Yes	0	8	7
132	R:R:I135	R:R:I218	7.36	No	No	0	8	8
133	R:R:V136	R:R:W137	11.03	Yes	No	4	7	6
134	R:R:C217	R:R:V136	3.42	No	Yes	4	4	7
135	R:R:K221	R:R:V136	4.55	No	Yes	0	5	7
136	R:R:V140	R:R:W137	4.9	No	No	0	5	6
137	R:R:F144	R:R:K143	12.41	No	No	0	4	3
138	R:R:P167	R:R:W195	8.11	No	Yes	0	7	5
139	R:R:C183	R:R:R172	4.18	No	Yes	0	9	5
140	R:R:E185	R:R:R172	9.3	No	Yes	0	5	5
141	R:R:E173	R:R:K186	10.8	No	No	0	4	3
142	R:R:L174	R:R:P181	3.28	Yes	No	0	5	4
143	R:R:A184	R:R:T175	3.36	No	No	0	3	2
144	R:R:D178	R:R:I177	9.8	No	No	0	1	1
145	R:R:I177	R:R:Y182	7.25	No	Yes	0	1	3
146	R:R:K180	R:R:Y182	4.78	No	Yes	0	3	3
147	R:R:K192	R:R:T189	4.5	No	No	0	4	3
148	R:R:I265	R:R:L193	4.28	Yes	No	0	4	2
149	R:R:I194	R:R:L269	7.14	No	No	0	4	1
150	R:R:V198	R:R:W195	3.68	No	Yes	0	3	5
151	R:R:A199	R:R:W195	7.78	No	Yes	0	5	5
152	R:R:I265	R:R:S196	6.19	Yes	No	0	4	5
153	R:R:I265	R:R:L197	5.71	Yes	No	0	4	4
154	R:R:L200	R:R:N258	4.12	No	Yes	1	5	8
155	R:R:K261	R:R:L200	9.87	Yes	No	1	5	5
156	R:R:F202	R:R:I201	3.77	No	No	0	4	5
157	R:R:F205	R:R:I201	3.77	No	No	0	4	5
158	R:R:F204	R:R:F205	7.5	Yes	No	0	8	4
159	R:R:F204	R:R:L208	4.87	Yes	Yes	1	8	6
160	R:R:F204	R:R:F250	5.36	Yes	Yes	1	8	9
161	R:R:F204	R:R:W254	4.01	Yes	Yes	1	8	9
162	R:R:F204	R:R:N258	20.54	Yes	Yes	1	8	8
163	R:R:P207	R:R:V206	3.53	No	No	0	9	6
164	R:R:F250	R:R:L208	3.65	Yes	Yes	1	9	6
165	R:R:I211	R:R:Y215	4.84	Yes	Yes	1	8	9
166	R:R:F250	R:R:I211	6.28	Yes	Yes	1	9	8
167	R:R:I243	R:R:Y215	7.25	No	Yes	0	7	9
168	R:R:V246	R:R:Y215	6.31	No	Yes	0	8	9
169	R:R:V247	R:R:Y215	5.05	No	Yes	0	8	9
170	R:R:I240	R:R:L222	4.28	No	No	0	6	8
171	R:R:H225	R:R:N233	10.2	No	No	0	6	4
172	R:R:H225	R:R:L236	3.86	No	No	0	6	7
173	R:R:K234	R:R:Y226	14.33	No	No	0	4	3
174	R:R:K237	R:R:Y226	4.78	No	No	0	5	3
175	R:R:G230	R:R:S229	3.71	No	No	0	3	4
176	R:R:H232	R:R:K231	10.48	No	No	0	4	4
177	R:R:F305	R:R:I242	5.02	No	No	0	6	8
178	R:R:I245	R:R:I301	4.42	No	No	0	5	8
179	R:R:F305	R:R:I245	3.77	No	No	0	6	5
180	R:R:F250	R:R:L251	3.65	Yes	No	0	9	6
181	R:R:F250	R:R:W254	9.02	Yes	Yes	1	9	9
182	R:R:F250	R:R:N294	6.04	Yes	Yes	1	9	9
183	R:R:S253	R:R:W254	7.41	No	Yes	0	8	9
184	R:R:A293	R:R:S253	3.42	No	No	0	5	8
185	R:R:A291	R:R:W254	3.89	No	Yes	0	8	9
186	R:R:N294	R:R:W254	7.91	Yes	Yes	1	9	9
187	R:R:L255	R:R:P256	3.28	No	No	0	6	9
188	R:R:P256	R:R:S287	5.34	No	Yes	0	9	7
189	R:R:F257	R:R:N258	7.25	Yes	Yes	1	7	8
190	R:R:F257	R:R:K261	8.69	Yes	Yes	1	7	5
191	R:R:F257	R:R:M284	4.98	Yes	Yes	0	7	4
192	R:R:K261	R:R:N258	4.2	Yes	Yes	1	5	8
193	R:R:A264	R:R:L280	4.73	No	Yes	0	4	4
194	R:R:L280	R:R:S277	7.51	Yes	No	0	4	3
195	R:R:Q281	R:R:S277	4.33	No	No	0	4	3
196	R:R:E285	R:R:L282	6.63	No	No	0	4	1
197	R:R:G288	R:R:P289	4.06	No	No	0	5	5
198	R:R:N294	R:R:N298	5.45	Yes	No	0	9	9
199	R:R:N298	R:R:Y302	10.47	No	Yes	0	9	9
200	R:R:D306	R:R:Y302	3.45	No	Yes	3	8	9
201	R:R:I309	R:R:Y302	3.63	Yes	Yes	3	8	9
202	R:R:I304	R:R:Y303	4.84	No	No	0	7	7
203	R:R:R310	R:R:Y303	7.2	No	No	0	8	7
204	R:R:I313	R:R:Y303	9.67	No	No	0	7	7
205	R:R:F305	R:R:I304	18.84	No	No	0	6	7
206	R:R:D306	R:R:I309	9.8	No	Yes	3	8	8
207	R:R:R310	R:R:R311	7.46	No	No	0	8	5
208	R:R:R311	R:R:V314	3.92	No	No	0	5	4
209	R:R:I301	R:R:V297	3.07	No	No	0	8	7
210	R:R:K234	R:R:S229	3.06	No	No	0	4	4
211	L:L:V81	R:R:M284	3.04	No	Yes	0	0	4
212	R:R:I191	R:R:T189	3.04	No	No	0	4	3
213	R:R:M112	R:R:T85	3.01	No	No	0	5	7
214	R:R:F260	R:R:G283	3.01	No	No	0	5	5
215	R:R:L83	R:R:S295	3	No	No	0	6	9
216	R:R:L98	R:R:S95	3	No	No	0	4	3
217	R:R:L174	R:R:S103	3	Yes	No	0	5	3
218	R:R:L222	R:R:S239	3	No	No	0	8	7
219	R:R:L290	R:R:S287	3	No	Yes	0	7	7
220	R:R:L208	R:R:V212	2.98	Yes	No	0	6	4
221	R:R:I218	R:R:I243	2.94	No	No	0	8	7
222	R:R:D306	R:R:S307	2.94	No	No	0	8	4
223	R:R:I309	R:R:I313	2.94	Yes	No	0	8	7
224	R:R:I242	R:R:K238	2.91	No	No	0	8	7
225	R:R:G165	R:R:Y111	2.9	No	Yes	0	7	6
226	R:R:E185	R:R:S171	2.87	No	No	0	5	5
227	R:R:I218	R:R:L222	2.85	No	No	0	8	8
228	R:R:I265	R:R:L269	2.85	Yes	No	0	4	1
229	R:R:C149	R:R:R146	2.79	No	No	0	4	6
230	R:R:L105	R:R:L88	2.77	No	No	0	6	6
231	R:R:L208	R:R:L209	2.77	Yes	No	0	6	4
232	R:R:A248	R:R:F244	2.77	No	No	0	5	5
233	R:R:M284	R:R:Q281	2.72	Yes	No	0	4	4
234	R:R:C162	R:R:Y111	2.69	No	Yes	0	4	6
235	R:R:R145	R:R:S141	2.64	Yes	No	0	7	5
236	R:R:F257	R:R:S287	2.64	Yes	Yes	0	7	7
237	R:R:R142	R:R:V139	2.62	No	No	0	5	5
238	R:R:F202	R:R:V206	2.62	No	No	0	4	6
239	R:R:F300	R:R:T46	2.59	No	No	0	6	5
240	R:R:F260	R:R:T259	2.59	No	No	0	5	6
241	R:R:F262	R:R:I201	2.51	No	No	0	5	5
242	R:R:T147	R:R:Y151	2.5	No	No	0	3	4
243	R:R:F39	R:R:L36	2.44	No	No	0	5	5
244	R:R:D148	R:R:R146	2.38	No	No	0	4	6
245	R:R:K192	R:R:W195	2.32	No	Yes	0	4	5
246	R:R:L164	R:R:W195	2.28	No	Yes	0	4	5
247	R:R:Q227	R:R:Y226	2.25	No	No	0	4	3
248	L:L:G76	L:L:P75	2.03	No	Yes	0	0	0
249	R:R:G50	R:R:P299	2.03	No	No	0	7	9
250	R:R:C296	R:R:G47	1.96	No	No	0	8	8
251	R:R:G268	R:R:S267	1.86	No	No	0	1	3
252	R:R:G50	R:R:V53	1.84	No	No	0	7	6
253	R:R:G283	R:R:V286	1.84	No	No	0	5	5
254	R:R:P37	R:R:V90	1.77	Yes	No	0	5	6
255	R:R:P138	R:R:V139	1.77	No	No	0	8	5
256	R:R:G56	R:R:M55	1.75	No	Yes	0	4	7
257	R:R:P190	R:R:T189	1.75	No	No	0	2	3
258	R:R:G108	R:R:K107	1.74	No	No	0	5	7
259	R:R:C149	R:R:V153	1.71	No	No	0	4	5
260	R:R:A249	R:R:V297	1.7	No	No	0	7	7
261	R:R:K180	R:R:P181	1.67	No	No	0	3	4
262	R:R:L176	R:R:P181	1.64	No	No	0	1	4
263	R:R:C223	R:R:I240	1.64	No	No	0	5	6
264	R:R:A219	R:R:I243	1.62	No	No	0	5	7
265	R:R:A77	R:R:M55	1.61	No	Yes	0	5	7
266	R:R:V139	R:R:V140	1.6	No	No	0	5	5
267	R:R:T85	R:R:V84	1.59	No	No	0	7	4
268	R:R:A188	R:R:L193	1.58	No	No	0	4	2
269	R:R:I157	R:R:V153	1.54	Yes	No	0	7	5
270	R:R:C223	R:R:Q227	1.53	No	No	0	5	4
271	R:R:L280	R:R:S267	1.5	Yes	No	0	4	3
272	R:R:L290	R:R:V252	1.49	No	No	0	7	5
273	R:R:I157	R:R:I160	1.47	Yes	No	0	7	4
274	R:R:I265	R:R:K261	1.45	Yes	Yes	0	4	5
275	R:R:Q271	R:R:S267	1.44	No	No	0	2	3
276	R:R:K107	R:R:L169	1.41	No	No	0	7	5
277	R:R:K192	R:R:L170	1.41	No	No	0	4	4
278	R:R:C217	R:R:R220	1.39	No	No	0	4	5
279	R:R:L96	R:R:L98	1.38	No	No	0	3	4
280	R:R:L163	R:R:L164	1.38	No	No	0	4	4
281	R:R:L263	R:R:L280	1.38	No	Yes	0	4	4
282	R:R:A184	R:R:Y182	1.33	No	Yes	0	3	3
283	R:R:F260	R:R:S287	1.32	No	Yes	0	5	7
284	R:R:R100	R:R:T101	1.29	No	Yes	0	3	7
285	R:R:S64	R:R:Y308	1.27	No	No	0	6	6
286	R:R:F104	R:R:L105	1.22	No	No	0	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P75	5.8875	4	0	0
2	R:R:P37	3.485	4	0	5
3	R:R:Y40	5.3	4	0	7
4	R:R:F44	8.3625	4	0	7
5	R:R:M55	2.89	4	0	7
6	R:R:R65	6.91	4	0	7
7	R:R:R66	9.5775	4	0	7
8	R:R:D69	9.1625	4	0	8
9	R:R:I72	5.0375	4	3	8
10	R:R:D79	7.7675	4	0	9
11	R:R:W89	5.5375	4	2	6
12	R:R:K92	5.34	4	2	5
13	R:R:W99	6.14833	6	2	8
14	R:R:T101	6.975	4	0	7
15	R:R:Y111	5.2075	4	0	6
16	R:R:H118	6.3475	4	0	6
17	R:R:C119	6.9675	4	6	7
18	R:R:L123	4.3975	4	0	8
19	R:R:D130	6.0375	4	5	8
20	R:R:Y132	8.3875	4	4	8
21	R:R:V136	7.2725	4	4	7
22	R:R:R145	5.055	4	5	7
23	R:R:I157	3.965	4	0	7
24	R:R:W158	6.85	4	6	9
25	R:R:R172	9.5175	4	0	5
26	R:R:L174	4.41	4	2	5
27	R:R:Y182	4.805	4	0	3
28	R:R:W195	4.834	5	0	5
29	R:R:F204	8.456	5	1	8
30	R:R:L208	3.5675	4	1	6
31	R:R:I211	5.785	4	1	8
32	R:R:Y215	7.57167	6	1	9
33	R:R:F250	5.55286	7	1	9
34	R:R:W254	5.97	7	1	9
35	R:R:F257	6.904	5	1	7
36	R:R:N258	9.0275	4	1	8
37	R:R:K261	6.0525	4	1	5
38	R:R:I265	4.096	5	0	4
39	R:R:L280	3.78	4	0	4
40	R:R:M284	6.0825	4	0	4
41	R:R:S287	3.075	4	0	7
42	R:R:N294	5.88	4	1	9
43	R:R:Y302	5.918	5	3	9
44	R:R:I309	6.11667	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A77	R:R:W89	17.425	5.19	No	Yes	0	0	6
2	R:R:K92	R:R:W89	13.2603	5.8	Yes	Yes	2	5	6
3	L:L:V74	R:R:K92	49.9641	4.55	No	Yes	0	0	5
4	L:L:P75	L:L:V74	50.4248	3.53	Yes	No	0	0	0
5	L:L:A77	R:R:Y40	17.1456	4	No	Yes	0	0	7
6	R:R:E93	R:R:K92	17.7308	4.05	No	Yes	0	4	5
7	R:R:E93	R:R:P37	16.1676	4.72	No	Yes	0	4	5
8	R:R:P37	R:R:Y40	12.9318	4.17	Yes	Yes	0	5	7
9	L:L:L78	R:R:F257	39.007	10.96	No	Yes	0	0	7
10	R:R:F257	R:R:M284	100	4.98	Yes	Yes	0	7	4
11	L:L:Q80	R:R:M284	91.0213	13.59	No	Yes	0	0	4
12	L:L:P75	L:L:Q80	90.1756	7.9	Yes	No	0	0	0
13	L:L:L78	L:L:P79	15.5711	4.93	No	No	0	0	0
14	L:L:L78	R:R:A291	23.5265	4.73	No	No	0	0	8
15	R:R:L86	R:R:Y40	31.4857	4.69	No	Yes	0	8	7
16	R:R:F292	R:R:L86	31.4857	3.65	No	No	0	7	8
17	R:R:F292	R:R:F82	31.9539	12.86	No	No	0	7	6
18	R:R:F82	R:R:N116	33.3661	7.25	No	No	0	6	8
19	R:R:I81	R:R:N116	17.4438	9.91	No	No	0	7	8
20	R:R:I81	R:R:W158	17.9347	4.7	No	Yes	0	7	9
21	R:R:A291	R:R:W254	23.5907	3.89	No	Yes	0	8	9
22	R:R:N294	R:R:W254	56.5981	7.91	Yes	Yes	1	9	9
23	R:R:N294	R:R:N298	85.3502	5.45	Yes	No	0	9	9
24	R:R:N298	R:R:Y302	84.1722	10.47	No	Yes	0	9	9
25	R:R:I72	R:R:Y302	30.0396	7.25	Yes	Yes	3	8	9
26	R:R:I72	R:R:L54	12.7091	4.28	Yes	No	0	8	9
27	R:R:F257	R:R:N258	67.5024	7.25	Yes	Yes	1	7	8
28	R:R:F204	R:R:N258	77.2588	20.54	Yes	Yes	1	8	8
29	R:R:F204	R:R:W254	30.8703	4.01	Yes	Yes	1	8	9
30	R:R:F204	R:R:F250	50.3153	5.36	Yes	Yes	1	8	9
31	R:R:F250	R:R:N294	29.4242	6.04	Yes	Yes	1	9	9
32	R:R:A76	R:R:L54	10.6626	3.15	No	No	0	8	9
33	R:R:I309	R:R:Y302	42.8356	3.63	Yes	Yes	3	8	9
34	R:R:I309	R:R:I313	28.8276	2.94	Yes	No	0	8	7
35	R:R:D69	R:R:I72	18.0442	4.2	Yes	Yes	0	8	8
36	R:R:D69	R:R:R65	20.0151	15.48	Yes	Yes	0	8	7
37	R:R:I70	R:R:R65	10.1454	3.76	No	Yes	0	6	7
38	R:R:M127	R:R:Y302	41.9974	4.79	No	Yes	0	9	9
39	R:R:F71	R:R:M127	52.5883	6.22	No	No	0	7	9
40	R:R:D130	R:R:F71	14.933	8.36	Yes	No	0	8	7
41	R:R:F250	R:R:I211	26.3394	6.28	Yes	Yes	1	9	8
42	R:R:I211	R:R:Y215	19.3581	4.84	Yes	Yes	1	8	9
43	R:R:R131	R:R:Y215	22.1295	9.26	No	Yes	0	9	9
44	R:R:M127	R:R:R131	22.054	3.72	No	No	0	9	9
45	R:R:C126	R:R:F71	55.084	12.57	No	No	0	7	7
46	R:R:C119	R:R:W158	17.3343	14.37	Yes	Yes	6	7	9
47	R:R:C119	R:R:L123	41.4801	3.17	Yes	Yes	0	7	8
48	R:R:L123	R:R:L75	11.4329	5.54	Yes	No	0	8	9
49	R:R:N116	R:R:V115	17.0512	4.43	No	No	0	8	6
50	R:R:S161	R:R:V115	21.3706	4.85	No	No	0	8	6
51	R:R:C119	R:R:S161	22.1182	3.44	Yes	No	0	7	8
52	R:R:C126	R:R:L123	54.5554	3.17	No	Yes	0	7	8
53	R:R:K92	R:R:W99	20.8458	6.96	Yes	Yes	2	5	8
54	L:L:P75	R:R:R172	39.1618	10.09	Yes	Yes	0	0	5
55	R:R:C183	R:R:R172	36.4697	4.18	No	Yes	0	9	5
56	R:R:C183	R:R:W99	21.5896	6.53	No	Yes	2	9	8
57	R:R:L174	R:R:W99	30.9685	3.42	Yes	Yes	2	5	8
58	R:R:L174	R:R:P181	37.4174	3.28	Yes	No	0	5	4
59	R:R:K180	R:R:P181	30.6815	1.67	No	No	0	3	4
60	R:R:K180	R:R:Y182	27.3022	4.78	No	Yes	0	3	3
61	R:R:L98	R:R:Y182	10.2926	5.86	No	Yes	0	4	3
62	R:R:C106	R:R:C183	14.2156	7.28	No	No	2	9	9
63	R:R:C106	R:R:L174	13.1508	7.94	No	Yes	2	9	5
64	R:R:T101	R:R:W99	14.4723	9.7	Yes	Yes	0	7	8
65	R:R:H118	R:R:M117	15.6088	7.88	Yes	No	0	6	7
66	R:R:H118	R:R:L164	18.1688	6.43	Yes	No	0	6	4
67	R:R:I157	R:R:L123	11.784	5.71	Yes	Yes	0	7	8
68	R:R:F204	R:R:F205	13.468	7.5	Yes	No	0	8	4
69	R:R:F205	R:R:I201	11.8105	3.77	No	No	0	4	5
70	R:R:C214	R:R:S128	12.2107	5.16	No	No	0	8	9
71	R:R:C214	R:R:Y132	11.1308	6.72	No	Yes	0	8	8
72	R:R:I243	R:R:Y215	15.59	7.25	No	Yes	0	7	9
73	R:R:I218	R:R:I243	13.4907	2.94	No	No	0	8	7
74	R:R:L164	R:R:W195	14.8839	2.28	No	Yes	0	4	5
75	R:R:I265	R:R:K261	12.0219	1.45	Yes	Yes	0	4	5
76	R:R:I218	R:R:L222	11.3272	2.85	No	No	0	8	8
77	R:R:I313	R:R:Y303	24.765	9.67	No	No	0	7	7
78	R:R:I304	R:R:Y303	16.549	4.84	No	No	0	7	7
79	R:R:F305	R:R:I304	14.4761	18.84	No	No	0	6	7
80	R:R:F257	R:R:S287	18.72	2.64	Yes	Yes	0	7	7
81	R:R:M284	R:R:Q281	15.6655	2.72	Yes	No	0	4	4
82	R:R:Q281	R:R:S277	13.7134	4.33	No	No	0	4	3
83	R:R:L280	R:R:S277	11.7538	7.51	Yes	No	0	4	3
84	R:R:M117	R:R:W254	10.9458	4.65	No	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:W72	R:R:K187	25.53	0	No	No	0	4	0	1
L:L:V74	R:R:K92	4.55	0	No	Yes	0	5	0	1
L:L:P75	R:R:R172	10.09	0	Yes	Yes	0	5	0	1
L:L:A77	R:R:Y40	4	0	No	Yes	0	7	0	1
L:L:A77	R:R:W89	5.19	0	No	Yes	0	6	0	1
L:L:L78	R:R:F257	10.96	0	No	Yes	0	7	0	1
L:L:L78	R:R:A291	4.73	0	No	No	0	8	0	1
L:L:P79	R:R:S114	7.13	0	No	No	0	5	0	1
L:L:P79	R:R:M117	6.71	0	No	No	0	7	0	1
L:L:Q80	R:R:M284	13.59	0	No	Yes	0	4	0	1
R:R:P37	R:R:Y40	4.17	0	Yes	Yes	5	7	2	1
R:R:E93	R:R:P37	4.72	0	No	Yes	4	5	2	2
R:R:L86	R:R:Y40	4.69	0	No	Yes	8	7	2	1
R:R:P289	R:R:Y40	8.34	0	No	Yes	5	7	2	1
R:R:K92	R:R:W89	5.8	2	Yes	Yes	5	6	1	1
R:R:W89	R:R:W99	3.75	2	Yes	Yes	6	8	1	2
R:R:S109	R:R:W89	7.41	0	No	Yes	5	6	2	1
R:R:E93	R:R:K92	4.05	0	No	Yes	4	5	2	1
R:R:K92	R:R:W99	6.96	2	Yes	Yes	5	8	1	2
R:R:C183	R:R:W99	6.53	2	No	Yes	9	8	2	2
R:R:R172	R:R:S110	14.5	0	Yes	No	5	5	1	2
R:R:H118	R:R:S114	6.97	0	Yes	No	6	5	2	1
R:R:S114	R:R:T168	9.59	0	No	No	5	4	1	2
R:R:H118	R:R:M117	7.88	0	Yes	No	6	7	2	1
R:R:M117	R:R:W254	4.65	0	No	Yes	7	9	1	2
R:R:C183	R:R:R172	4.18	2	No	Yes	9	5	2	1
R:R:E185	R:R:R172	9.3	0	No	Yes	5	5	2	1
R:R:A291	R:R:W254	3.89	0	No	Yes	8	9	1	2
R:R:F257	R:R:N258	7.25	1	Yes	Yes	7	8	1	2
R:R:F257	R:R:K261	8.69	1	Yes	Yes	7	5	1	2
R:R:F257	R:R:M284	4.98	1	Yes	Yes	7	4	1	1
R:R:K261	R:R:N258	4.2	1	Yes	Yes	5	8	2	2
L:L:V81	R:R:M284	3.04	0	No	Yes	0	4	0	1
R:R:M284	R:R:Q281	2.72	0	Yes	No	4	4	1	2
R:R:F257	R:R:S287	2.64	1	Yes	Yes	7	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZQE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	263
Number of Links	286
Number of Hubs	44
Number of Links mediated by Hubs	158
Number of Communities	6
Number of Nodes involved in Communities	33
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	61006
Length Of Smallest Path	3
Average Path Length	14.5009
Length of Longest Path	28
Minimum Path Strength	1.44
Average Path Strength	6.43305
Maximum Path Strength	14.02
Minimum Path Correlation	0.7
Average Path Correlation	0.928812
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	45.8663
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.0072
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of biological process • regulation of cell motility • regulation of cellular process • regulation of leukocyte migration • biological regulation • lymphocyte migration • regulation of lymphocyte migration • leukocyte migration • immune system process • regulation of locomotion • regulation of T cell migration • mononuclear cell migration • regulation of cell migration • cell migration • cellular process • regulation of immune system process • T cell migration • cell motility • regulation of mononuclear cell migration • locomotion • establishment of organelle localization • multicellular organismal process • regulated exocytosis • cellular localization • response to stimulus • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • lysosome localization • defense response to fungus • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to stress • response to external stimulus • response to fungus • response to external biotic stimulus • response to biotic stimulus • cell population proliferation • regulation of cell population proliferation • regulation of keratinocyte proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • keratinocyte proliferation • multicellular organismal-level homeostasis • leukocyte homeostasis • T cell homeostasis • homeostatic process • homeostasis of number of cells • lymphocyte homeostasis • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • cell chemotaxis • chemotaxis • lymphocyte chemotaxis • cellular response to chemical stimulus • taxis • response to chemical • leukocyte chemotaxis • regulation of cell cycle phase transition • regulation of cell cycle process • negative regulation of cell cycle G1/S phase transition • negative regulation of biological process • negative regulation of cell cycle • cell cycle phase transition • regulation of cell cycle G1/S phase transition • negative regulation of cell cycle process • cell cycle G1/S phase transition • negative regulation of cellular process • negative regulation of cell cycle phase transition • cell cycle • regulation of cell cycle • cell cycle process • negative regulation of cell division • cell division • regulation of cell division • defense response to Gram-positive bacterium • defense response to bacterium • response to bacterium • cellular anatomical structure • extracellular region • extracellular space • binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • transporter activity • carbohydrate transmembrane transporter activity • transmembrane transporter activity • oligosaccharide binding • disaccharide binding • carbohydrate binding • maltose binding • protein binding • virus receptor activity • exogenous protein binding • molecular transducer activity • coreceptor activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • cellular response to stress • DNA damage response • carbohydrate transport • oligosaccharide transport • disaccharide transport • maltose transport • polysaccharide localization • dextrin transport • macromolecule localization • maltodextrin transmembrane transport • polysaccharide transport • response to disaccharide • response to oxygen-containing compound • detection of maltose stimulus • detection of stimulus • response to carbohydrate • detection of chemical stimulus • detection of disaccharide stimulus • response to maltose • detection of carbohydrate stimulus • developmental process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • symbiont entry into host cell • viral process • symbiont entry into host • viral life cycle • biological process involved in interaction with host • biological process involved in symbiotic interaction • periplasmic space • ATPase dependent transmembrane transport complex • protein-containing complex • plasma membrane protein complex • membrane • plasma membrane • membrane protein complex • transporter complex • ATP-binding cassette (ABC) transporter complex • cell periphery • transmembrane transporter complex • ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing • maltose transport complex • outer membrane-bounded periplasmic space • cell envelope • membrane-bounded organelle • intracellular anatomical structure • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • cytoplasm • vesicle • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cellular component organization or biogenesis • microtubule cytoskeleton organization involved in mitosis • spindle organization • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49685
Sequence	>8ZQE_nogp_Chain_R F L P V F Y T A V F L T G V L G N L V L M G A L H F K P G S R R L I D I F I I N L A A S D F I F L V T L P L W V D K E A S L G L W R T G S F L C K G S S Y M I S V N M H C S V L L L T C M S V D R Y L A I V W P V V S R K F R R T D C A Y V V C A S I W F I S C L L G L P T L L S R E L T L I D D K P Y C A E K K A T P I K L I W S L V A L I F T F F V P L L S I V T C Y C C I A R K L C A H Y Q Q S G K H N K K L K K S I K I I F I V V A A F L V S W L P F N T F K F L A I V S G L R Q S A I L Q L G M E V S G P L A F A N S C V N P F I Y Y I F D S Y I R R A I V H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZQE	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(C11)	-	Gi1/β1/γ1	2.9	2024-07-10	doi.org/10.1038/s41421-024-00698-5
	8ZQE (No Gprot)	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(C11)	-		2.9	2024-07-10	doi.org/10.1038/s41421-024-00698-5
	8YJP	C	Orphan	Orphan	GPR156	Homo sapiens	-	-	-	3.09	2025-02-05	doi.org/10.1038/s41467-024-54681-5
	8YK0	C	Orphan	Orphan	GPR156	Homo sapiens	-	-	Gi3/β1/γ2	2.4	2025-02-05	doi.org/10.1038/s41467-024-54681-5
	8YK0 (No Gprot)	C	Orphan	Orphan	GPR156	Homo sapiens	-	-		2.4	2025-02-05	doi.org/10.1038/s41467-024-54681-5
	8IEB	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	3.03	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IED	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	Go/β1/γ2	3.33	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IED (No Gprot)	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-		3.33	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IEI	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	2.62	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	8IEP	C	Orphan	Orphan	GPR156	Homo sapiens	A1LYA	-	-	2.61	2024-02-14	doi.org/10.1038/s41594-024-01224-7
	7EWL	C	Orphan	Orphan	GPR158	Homo sapiens	-	-	-	3.52	2021-12-01	doi.org/10.1038/s41467-021-27147-1
	7EWP	C	Orphan	Orphan	GPR158	Homo sapiens	-	-	B5; RGS7	4.3	2021-12-01	doi.org/10.1038/s41467-021-27147-1
	7EWR	C	Orphan	Orphan	GPR158	Homo sapiens	-	-	B5; RGS7	4.7	2021-12-01	doi.org/10.1038/s41467-021-27147-1
	7SHE	C	Orphan	Orphan	GPR158	Homo sapiens	-	-	-	3.4	2021-12-01	doi.org/10.1126/science.abl4732
	7SHF	C	Orphan	Orphan	GPR158	Homo sapiens	-	-	B5; RGS7	3.4	2021-12-01	doi.org/10.1126/science.abl4732

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