Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.37 1.90571403
2G.S1.06 4.262354198
3G.s1h1.04 2.48133409
4G.S2.02 1.4797405
5G.S3.03 5.39244608
6G.S3.04 7.72386417
7G.S3.06 6.89315517
8G.H2.01 5.12476419
9G.H2.05 6.09214418
10G.H2.06 4.9142719
11G.H2.07 6.2246519
12G.h2s4.01 7.42291519
13G.S4.04 4.16151409
14G.s4h3.04 2.5478408
15G.H3.01 2.90667409
16G.H3.08 2.97505508
17G.H3.09 4.915875209
18G.H3.13 9.028145206
19G.H3.17 9.21611515
20G.S5.05 4.12238579
21G.S5.07 2.88636509
22G.HG.01 5.03815466
23G.HG.03 3.15411406
24G.hgh4.04 1.6484406
25G.hgh4.05 8.68513506
26G.hgh4.11 3.63998405
27G.hgh4.20 4.66404403
28G.hgh4.21 4.9202404
29G.H4.03 3.1909404
30G.H4.08 5.6337463
31G.H4.10 8.11573507
32G.H4.12 5.71082564
33G.H4.13 3.34197503
34G.H4.15 6.82624408
35G.H4.16 3.05627464
36G.h4s6.08 2.34031405
37G.h4s6.20 6.15098484
38G.S6.02 7.15001588
39G.S6.05 6.42031565
40G.H5.03 4.88418479
41G.H5.05 4.278634125
42G.H5.06 5.38901474
43G.H5.08 4.622046128
44G.H5.13 4.40577488
45G.H5.17 7.88318585
46G.H5.20 3.8491408
47G.H5.25 2.77411408
48b.1x1 1.68302504
49b.1x3 1.31961401
50b.1x4 1.95529408
51b.l1x3 8.63661549
52b.l1x6 8.7684519
53b.b2x1 5.638518
54b.b2x5 5.72916647
55b.b3x3 3.4981408
56b.l3x1 7.12903419
57b.l3x2 5.623625189
58b.b4x6 8.65661649
59b.b5x2 5.29092547
60b.b5x3 4.76123749
61b.b5x7 4.80623407
62b.l5x1 4.109785148
63b.l5x5 8.30994519
64b.b6x5 4.23774506
65b.l6x5 5.419574154
66b.b7x1 5.402024154
67b.b8x4 4.999275146
68b.l8x5 2.12097403
69b.l9x3 7.10298519
70b.l9x6 5.34122718
71b.b10x5 4.08424509
72b.l10x1 3.77716403
73b.b11x4 5.27795419
74b.l11x2 7.81022419
75b.b12x6 8.54536618
76b.b13x7 7.10789557
77b.l13x3 6.89628659
78b.l13x6 5.18756519
79b.l13x7 4.53229459
80b.b14x3 3.97141455
81b.b15x1 5.92881559
82b.l15x1 5.07797517
83b.l15x2 5.59443459
84b.b16x4 9.73838456
85b.b16x5 4.84466405
86b.b16x6 8.3578658
87b.b16x7 6.509064169
88b.b17x4 5.165084165
89b.b17x5 5.81971537
90b.b17x7 7.12713438
91b.l17x3 7.78466739
92b.l17x6 8.63346419
93b.b18x3 4.84839438
94b.l18x1 5.770957136
95b.b19x2 6.53182536
96b.b19x4 5.59299438
97b.l19x1 5.32468419
98b.l19x2 7.34338439
99b.b20x2 5.61865436
100b.b20x4 10.2024538
101b.b20x6 7.00402536
102b.b20x7 4.74468409
103b.l20x2 7.3061409
104b.b21x1 5.94512637
105b.b21x3 6.68506436
106b.b21x5 4.94242404
107b.b21x7 5.31217605
108b.b22x5 5.112175137
109b.l22x5 6.24825219
110b.b23x6 6.362536177
111b.l23x1 5.70647516
112b.b24x4 7.177224176
113b.b24x6 5.655564178
114b.l25x3 8.67345499
115b.l25x6 11.5941518
116b.b26x3 3.43363406
117b.l26x3 6.56774447
118b.l27x1 9.25847719
119b.l27x2 8.19691499
120b.b28x3 3.85243407
121b.b28x4 6.75294496
122b.b28x6 7.45213599
123g.h1x1 1.21787502
124g.h1x8 1.9932407
125g.h1x11 2.93946409
126g.h1x14 4.47872439
127g.l1x4 4.30301408
128g.h2x9 1.50056404
129g.h2x11 8.44374136
130g.ctx3 5.66679509
131g.ctx6 3.25131406
132g.ctx14 5.039925109
133g.ctx15 5.889654109
134g.ctx16 4.602977108
135g.ctx17 3.91405407
1361x50 5.35359409
1371x60 2.90878506
138I1x48 3.42358406
1392x42 3.86489628
1402x46 4.47485429
1412x50 5.98587529
1422x57 4.25465408
143E1x50 5.752877118
144E1x52 5.751014116
1453x24 3.29764115
1463x28 5.05274406
1473x46 3.16299429
1483x49 5.5324429
1493x50 5.67824429
150I2x51 5.0412407
151I2x53 6.18782428
1524x38 2.59273408
1534x58 3.686885235
154E2 10.33811523
1555x39 5.31938427
1565x47 7.05364627
1575x58 4.49697629
1585x62 3.60157405
159I3 1.17099502
1606x37 2.66436408
1616x44 4.39643529
1626x48 5.69097828
1636x51 6.35574627
1646x52 8.35258527
165E3 4.33712624
1667x37 2.85028405
1677x39 6.19485406
1687x42 5.91703627
1697x49 4.94075529
1707x53 4.47361529
1718x50 3.8408608
172Lig 6.548441220
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x5 b.l4x2 41.311618.933NoNo054
2b.l4x2 g.ctx15 40.793411.1326NoYes1049
3b.l26x5 g.ctx15 42.98953.58175NoYes059
4b.l26x5 g.ctx4 47.59135.3472NoNo057
5g.ctx3 g.ctx4 47.67923.78977YesNo097
6g.ctx3 g.ctx6 76.23056.65877YesYes096
7b.l22x5 g.ctx6 75.97063.19708YesYes096
8b.l22x5 b.l24x2 75.25127.93272YesNo096
9b.h2x5 b.l24x2 75.11963.02983NoNo056
10b.h2x1 b.h2x5 74.72353.20347NoNo055
11b.b21x5 b.h2x1 74.59096.10506YesNo045
12b.b21x5 b.b21x7 73.99178.614YesYes045
13b.b21x7 b.b24x6 71.13227.54141YesYes058
14b.b23x6 b.b24x6 70.60065.87808YesYes1778
15b.b23x6 b.l23x2 70.52794.05185YesNo078
16b.l21x7 b.l23x2 70.31766.27526NoNo058
17b.l21x7 b.l23x1 70.17713.80711NoYes056
18G.H3.17 b.l23x1 35.20516.64987YesYes156
19G.H3.17 b.l27x1 34.63964.341YesYes159
20b.l23x1 b.l25x6 34.738313.0045YesYes168
21b.l25x6 b.l27x1 34.585620.0275YesYes189
22b.b2x1 b.l27x1 63.36975.29667YesYes189
23g.ctx3 g.ctx5 99.78143.38789YesNo099
24b.lhb1x11 g.ctx5 99.81783.73466NoNo049
25b.b25x7 b.lhb1x11 99.85434.58988NoNo074
26b.b25x7 b.b28x6 10013.5873NoYes079
27b.b27x3 b.b28x6 33.23227.1666NoYes089
28b.b27x3 b.l25x3 33.52566.96119NoYes089
29b.l25x3 b.l27x2 66.6227.24163YesYes999
30b.l25x4 b.l27x2 66.47846.54132NoYes059
31I1x49 b.l25x4 66.42145.57186NoNo055
321x60 I1x49 99.73233.46593YesNo065
331x60 I1x50 99.04653.4674YesNo068
348x50 I1x50 98.95084.72044YesNo088
352x40 8x50 97.44313.90246NoYes098
362x37 2x40 97.34647.02632NoNo079
372x37 2x39 97.16872.57381NoNo078
382x39 3x49 97.07185.2117NoYes089
393x49 I2x53 32.77857.25671YesYes298
403x53 I2x53 31.75827.74554NoYes088
413x53 G.H5.19 31.62734.47818NoNo088
42G.H5.15 G.H5.19 31.36533.90439NoNo088
43G.H5.15 I2x50 31.23424.10118NoNo088
44G.H5.12 I2x50 11.1764.03298NoNo078
45G.H5.12 I2x51 11.0423.10454NoYes077
46b.b28x4 b.b28x6 66.81196.89462YesYes969
47b.b28x4 b.l25x3 33.24117.47823YesYes969
48b.b1x5 b.b28x4 33.64316.5331NoYes036
49b.b1x5 b.l1x1 33.6288.29875NoNo037
50I1x48 b.l1x1 33.58735.51233YesNo067
51I1x48 I1x49 33.40493.626YesNo065
52b.b2x1 b.b6x1 58.63074.50427YesNo089
53b.b6x1 b.l9x6 58.09875.92819NoYes098
54G.H2.07 b.l9x6 45.73164.68978YesYes198
55G.H2.04 G.H2.07 45.55037.46707NoYes099
56G.H2.04 G.H3.08 45.36536.03176NoYes098
57G.H3.08 G.S4.04 44.66315.22384YesYes089
58G.H5.16 I2x50 19.95323.8117NoNo068
595x68 G.H5.16 19.68116.95371NoNo076
60G.H5.10 G.S6.02 17.781410.3176NoYes078
61G.S5.05 G.s6h5.01 14.19946.15883YesNo799
62G.S5.07 G.s6h5.01 13.65084.75096YesNo099
63G.S4.04 G.S4.06 20.84063.69918YesNo097
64G.H3.09 G.S4.04 23.45843.89905YesYes099
65G.H4.15 G.S4.06 20.46734.47529YesNo087
66G.H3.09 G.H4.15 20.50146.34246YesYes098
67G.S5.06 G.S6.05 16.87034.27244NoYes085
68G.S5.04 G.S5.06 17.24913.78826NoNo098
69G.H4.15 G.S5.04 18.00197.91748YesNo089
70G.H4.10 G.H4.14 18.19867.46529YesNo075
71G.H3.06 G.H4.14 19.29223.7799NoNo065
72G.H3.06 G.H4.15 22.62588.56972NoYes068
732x42 3x46 69.77393.30226YesYes289
742x42 3x49 72.2536.68801YesYes289
75b.l2x3 b.l2x5 38.53963.76533NoNo085
76b.b3x1 b.l2x3 38.44175.27933NoNo058
77b.b3x1 b.b6x5 38.34383.97954NoYes056
78b.b2x4 b.b6x5 35.08013.38111NoYes066
79b.b10x4 b.b2x4 34.979512.1722NoNo066
80b.b10x2 b.b10x4 33.89473.70205NoNo066
81b.b10x2 b.b14x3 33.79454.83517NoYes065
82b.b14x3 b.b15x1 32.38053.72019YesYes559
83b.b15x1 b.b16x6 31.791811.1777YesYes598
84b.b16x4 b.b16x6 15.4448.25483YesYes568
85b.b16x4 b.b17x6 15.383710.4857YesNo067
86b.b17x6 g.h1x14 15.27744.39324NoYes079
87b.b21x1 g.h1x14 19.26693.74309YesYes379
88b.1x19 b.b21x1 10.74627.61919NoYes067
89b.b16x6 b.b17x3 15.55454.82534YesNo585
90b.b17x3 g.h1x10 15.44883.57545NoNo059
91g.h1x10 g.h1x14 15.23566.14007NoYes099
92b.b17x5 g.h1x14 11.02953.63847YesYes379
93b.b17x7 b.b20x6 10.19588.28109YesYes386
947x39 7x42 10.80218.31056YesYes067
956x48 6x51 24.05773.74213YesYes287
966x48 7x45 57.69729.32602YesNo089
977x45 7x49 58.04636.14293NoYes099
987x49 7x53 60.29812.96715YesYes299
993x46 7x53 61.2734.32164YesYes299
1007x42 Lig 19.24673.38533YesYes270
1016x51 Lig 15.638912.409YesYes270
1023x36 Lig 15.62627.25963NoYes070
1033x36 6x48 15.75175.95502NoYes078
1046x52 Lig 15.82576.30222YesYes270
1056x48 6x52 16.14775.86352YesYes287
1062x56 7x42 12.19933.33628NoYes287
1072x56 3x28 20.42583.76336NoYes086
1083x28 E1x50 11.14227.21156YesYes068
109E2 Lig 10.57383.66947YesYes230
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x327.245732NoNo8721
2x567x423.336282NoYes8721
2x577x424.977290YesYes8721
3x327x428.208662NoYes7711
3x32Lig12.74292NoYes7010
3x334x574.144860NoNo6712
3x33Lig9.821570NoYes6010
3x366x485.955020NoYes7812
3x36Lig7.259630NoYes7010
3x375x4615.301420NoNo7721
4x605x395.112742NoYes6722
4x63E24.885090NoYes5321
E2E251.34062YesYes3311
5x39E26.109772YesYes7321
E2E2x523.323642YesNo3411
E2E2x516.220722YesNo3312
E2x52Lig5.696592NoYes4010
5x36E23.375332NoYes5321
5x395x436.976222YesNo7621
5x43Lig5.009930NoYes6010
5x446x524.486270NoYes6721
5x461Lig3.28620NoYes7010
5x476x482.935472YesYes7822
5x476x5219.132YesYes7721
6x486x513.742132YesYes8721
6x486x525.863522YesYes8721
6x516x525.980862YesYes7711
6x517x386.814172YesNo7611
6x51Lig12.4092YesYes7010
6x52Lig6.302222YesYes7010
6x55Lig3.734812NoYes6010
7x387x427.284032NoYes6711
7x38Lig5.263572NoYes6010
7x397x428.310560YesYes6721
7x42Lig3.385332YesYes7010
4x60E24.255792NoYes6321
5x365x393.078782NoYes5722
6x517x343.126872YesNo7412
E2Lig3.669472YesYes3010
E2E37.791632YesYes3412
6x516x556.061342YesNo7611
4x61E24.682662NoYes5321
4x64E23.629230NoYes0321
3x29E2x522.431940NoNo6421
3x22E22.060582NoYes3321
5x40E21.996780NoYes6321
2x67E20.3899552NoYes4321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
92.31Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
92.31Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
91.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
91.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
91.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
91.67Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
91.67Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
91.67Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
91.67Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
91.67Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
91.67Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
91.67Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
91.67Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
91.67Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
91.67Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
91.67Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
91.67Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
91.67Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
84.62Single2RH1S-Carazolol2RH1-β2-S-Carazolol
84.62Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
84.62Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
84.62Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
84.62Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
84.62Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
84.62Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
84.62Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
84.62Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
84.62Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
84.62Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
84.62Consensusamine_offonOrthosteric Ligandamine_off amine_on
84.62Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
84.62Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
84.62Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
84.62Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
84.62Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
84.62Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
84.62Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
84.62Consensustrace-amine_onOrthosteric Ligandta1_on
83.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
83.33Single6PS0S-Carazolol6PS0-β2-S-Carazolol
83.33Single6PS4ICI118-5516PS4-β2-ICI118-551
83.33Single6PS5S-Propranolol6PS5-β2-S-Propranolol
83.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
83.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
83.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
83.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
83.33Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
83.33Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
83.33Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
83.33Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
83.33Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
83.33Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
83.33Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
83.33Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
83.33Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
80.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
80.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
78.57Single2YDVNECA2YDV-A2A-NECA
78.57Single4UHRCGS216804UHR-A2A-CGS21680
78.57Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
78.57Single5D5AS-Carazolol5D5A-β2-S-Carazolol
78.57Single5D5BS-Carazolol5D5B-β2-S-Carazolol
78.57Single5G53NECA5G53-A2A-NECA-Gs
78.57Single6H7JIsoprenaline6H7J-β1-Isoprenaline
78.57Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
78.57Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
78.57Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
78.57Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
78.57Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
78.57Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
78.57Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
78.57Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
78.57Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
78.57Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
78.57Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
78.57Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
78.57Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
78.57Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
78.57Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
78.57Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
78.57Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
76.92Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
76.92Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
76.92Single3NY8ICI118-5513NY8-β2-ICI118-551
76.92Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
76.92Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
76.92Single4GBRS-Carazolol4GBR-β2-S-Carazolol
76.92Single6H7MSalbutamol6H7M-β1-Salbutamol
76.92Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
76.92Single6PS1Timolol6PS1-β2-Timolol
76.92Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
76.92Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
76.92Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
76.92Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
76.92Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
76.92Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
76.92Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
76.92Single8JJOAlprenolol8JJO-β2-Alprenolol
76.92Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
76.92Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
76.92Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
76.92Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
76.92Single9CHXS-Carazolol9CHX-β2-S-Carazolol
76.92Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
76.92Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
76.92Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
76.92Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
76.92Consensusdopamine_offOrthosteric Ligandd2_off d3_off
76.92Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
75.00Single3NY9ICI118-5513NY9-β2-ICI118-551
75.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
75.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
75.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
75.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
75.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
75.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
75.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
75.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
75.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
75.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
75.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
75.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
75.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
75.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
75.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
75.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
75.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
75.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
73.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
73.33Single3D4STimolol3D4S-β2-Timolol
73.33Single4AMIBucindolol4AMI-β1-Bucindolol
73.33Single4LDEBI1671074LDE-β2-BI167107
73.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
73.33Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
73.33Single8JJ8Formoterol8JJ8-β2-Formoterol
73.33Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
73.33Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
73.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
73.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
73.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
71.43Single2Y03Isoprenaline2Y03-β1-Isoprenaline
71.43Single2YCWS-Carazolol2YCW-β1-S-Carazolol
71.43Single5D6LS-Carazolol5D6L-β2-S-Carazolol
71.43Single5JQHS-Carazolol5JQH-β2-S-Carazolol
71.43Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
71.43Single6E67BI1671076E67-β2-BI167107-Gs (fused)
71.43Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
71.43Single7WC6LSD7WC6-5-HT2A-LSD
71.43Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
71.43Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
71.43Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
71.43Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
71.43Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
71.43Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
71.43Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
71.43Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
71.43Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
69.23Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
69.23Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
69.23Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
69.23Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
69.23Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
69.23Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
69.23Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
69.23Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
69.23Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
69.23Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
69.23Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
69.23Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
69.23Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
69.23Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
69.23Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
69.23Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
69.23Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
69.23Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
69.23Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
69.23Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
69.23Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
69.23Consensusalpha1_onOrthosteric Ligandalpha1a_on
69.23Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
69.23Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
69.23Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
68.75Single6H7LDobutamine6H7L-β1-Dobutamine
68.75Single6IBLArformoterol6IBL-β1-Arformoterol
68.75Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
68.75Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
68.75Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
68.75Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
68.75Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
66.67Single3P0GBI1671073P0G-β2-BI167107
66.67Single3PBLEticlopride3PBL-D3-Eticlopride
66.67Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
66.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
66.67Single6J21Aprepitant6J21-NK1-Aprepitant
66.67Single6WGTLSD6WGT-5-HT2A-LSD
66.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
66.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
66.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
66.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
66.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
66.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
66.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
66.67Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
66.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
66.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
66.67Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
66.67Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
66.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
66.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
66.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
66.67Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
66.67Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
64.71Single4UG2CGS216804UG2-A2A-CGS21680
64.71Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
64.29Single2Y02Carmoterol2Y02-β1-Carmoterol
64.29Single2Y04Salbutamol2Y04-β1-Salbutamol
64.29Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
64.29Single4QKX35V4QKX-β2-35V
64.29Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
64.29Single7BU7BI1671077BU7-β1-BI167107
64.29Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
64.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
64.29Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
64.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
64.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
64.29Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
64.29Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
64.29Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
64.29Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
64.29Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
64.29Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
64.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
64.29Single8X64Desloratadine8X64-H1-Desloratadine
64.29Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
64.29Consensus5ht5_onOrthosteric Ligand5ht5a_on
64.29Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
64.29Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
64.29Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
64.29Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
64.29Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
64.29Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
64.29Consensusalpha2_onOrthosteric Ligandalpha2b_on
64.29Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
64.29Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
64.29Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
62.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
62.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
62.50Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
62.50Single6MXTSalmeterol6MXT-β2-Salmeterol
62.50Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
62.50Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
62.50Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
62.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
62.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
62.50Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
62.50Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
62.50Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
62.50Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
62.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
62.50Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
62.50Consensusalpha1_offOrthosteric Ligandalpha1a_off
62.50Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
62.50Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
62.50Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
61.54Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
61.54Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
61.54Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
61.54Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
61.54Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
61.54Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
61.54Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
61.54Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
61.54Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
61.54Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
61.54Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
61.54Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
61.54Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
61.11Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
61.11Single4IARErgotamine4IAR-5-HT1B-Ergotamine
61.11Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
61.11Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
61.11Single8WDTphotoNECA8WDT-A2A-photoNECA
61.11Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
61.11Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
60.00Single5C1MBU725C1M-μ-BU72
60.00Single5TVNLSD5TVN-5-HT2B-LSD
60.00Single5WIUNemonapride5WIU-D4-Nemonapride
60.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
60.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
60.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
60.00Single6PS6Timolol6PS6-β2-Timolol
60.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
60.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
60.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
60.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
60.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
58.82Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
58.82Single7UM4AS26747237UM4-5-HT5A-AS2674723
58.82Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
58.82Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
58.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
58.82Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
58.82Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
58.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
58.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
58.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
58.33Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
57.89Single6HLOAprepitant6HLO-NK1-Aprepitant
57.14Single2YDOAdenosine2YDO-A2A-Adenosine
57.14Single6A94Zotepine6A94-5-HT2A-Zotepine
57.14Single6KUXRS-799486KUX-α2a-RS-79948
57.14Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
57.14Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
57.14Single6TPGEMPA6TPG-OX2-EMPA
57.14Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
57.14Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
57.14Single7UL3Famotidine7UL3-H2-Famotidine
57.14Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
57.14Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
57.14Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
57.14Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
57.14Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
57.14Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
57.14Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
57.14Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
57.14Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
57.14Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
57.14Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
56.25Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
56.25Single4U15Tiotropium4U15-M3-Tiotropium
56.25Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
56.25Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
56.25Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
56.25Single6OL9Tiotropium6OL9-M5-Tiotropium
56.25Single6TQ7SB-3348676TQ7-OX1-SB-334867
56.25Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
56.25Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
56.25Single8E0GBU728E0G-μ-BU72
56.25Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
56.25Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
56.25Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
56.25Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
56.25Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
56.25Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
56.25Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
56.25Consensusa2_onOrthosteric Liganda2b_on
56.25Consensusa2_on_gpOrthosteric Liganda2b_on_gp
56.25Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
56.25Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
56.25Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
56.25Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
56.25Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
56.25Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
56.25Consensustachykinin_offOrthosteric Ligandnk1_off
55.56Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
55.56Single8X5YAstemizole8X5Y-H1-Astemizole
53.85Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
53.85Single7SRQLSD7SRQ-5-HT2B-LSD
53.85Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.85Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
53.85Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
53.85Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
53.85Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
53.85Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
53.85Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
53.85Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
53.85Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
53.85Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
53.85Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
53.33Single2Y01Dobutamine2Y01-β1-Dobutamine
53.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
53.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
53.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
53.33Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
53.33Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
53.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
53.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
53.33Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
53.33Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
53.33Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
53.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
53.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
53.33Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
53.33Single7UL4Alvimopan7UL4-μ-Alvimopan
53.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
53.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
53.33Single8JXRLSD8JXR-D1-LSD
53.33Single8T1WCVN4248T1W-GPR6-CVN424
53.33Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
53.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
53.33Single8X63Mepyramine8X63-H1-Mepyramine
53.33Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
53.33Consensusa3_onOrthosteric Liganda3a_on
53.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
53.33Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
53.33Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
53.33Consensushistamine_offOrthosteric Ligandh1_off
52.94Single4RWADIPP-NH24RWA-δ-DIPP-NH2
52.94Single5CXVTiotropium5CXV-M1-Tiotropium
52.94Single7YITNalfurafine7YIT-κ-Nalfurafine
52.94Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.94Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
52.94Single8JJLOlodaterol8JJL-β2-Olodaterol
52.94Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
52.94Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
52.94Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
52.94Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
52.94Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
52.63Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
52.63Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
52.63Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
52.63Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
50.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
50.00Single2Y00Dobutamine2Y00-β1-Dobutamine
50.00Single3QAKUK-4320973QAK-A2A-UK-432097
50.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
50.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
50.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
50.00Single5WQCEMPA5WQC-OX2-EMPA
50.00Single5X93K-87945X93-ETB-K-8794
50.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
50.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
50.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
50.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
50.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
50.00Single6TODEMPA6TOD-OX1-EMPA-Na
50.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
50.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
50.00Single7EZCUKA7EZC-A2A-UKA
50.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
50.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
50.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
50.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
50.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
50.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
50.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
50.00Single8IWESpermidine8IWE-TA9-Spermidine
50.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
50.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
50.00Single8JXSPF-61428JXS-D1-PF-6142
50.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
50.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
50.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
50.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
50.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
50.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
50.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
50.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
50.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
50.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
50.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
50.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
50.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
50.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
50.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.62Single5WF5UK-4320975WF5-A2A-UK-432097
47.62Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
47.37Single5WF6UK-4320975WF6-A2A-UK-432097
47.37Single6PT3DPI-2876PT3-δ-DPI-287
47.37Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
47.37Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.37Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
47.06Single5V54Methiothepin5V54-5-HT1B-Methiothepin
47.06Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
47.06Single6J20Aprepitant6J20-NK1-Aprepitant
47.06Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
47.06Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
47.06Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
47.06Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
47.06Single8EA0Iperoxo8EA0-M3-Iperoxo
47.06Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
47.06Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
47.06Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
47.06Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
47.06Single8XVLZibotentan8XVL-ETA-Zibotentan
47.06Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
47.06Consensus5ht1_offOrthosteric Ligand5ht1b_off
47.06Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
47.06Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
47.06Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
46.67Single3RZECidoxepin3RZE-H1-Cidoxepin
46.67Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
46.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
46.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
46.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
46.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
46.67Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
46.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
46.67Single6TPNHTL66416TPN-OX2-HTL6641
46.67Single6VI4JDTic6VI4-κ-JDTic
46.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
46.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
46.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
46.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
46.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
46.67Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
46.67Single9BJKNaloxone9BJK-μ-Naloxone-NAM
46.67Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
46.15Single3UZAGTPL92363UZA-A2A-GTPL9236
46.15Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
46.15Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
46.15Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
46.15Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
46.15Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
46.15Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
46.15Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
46.15Consensus5ht2_onOrthosteric Ligand5ht2b_on
46.15Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
46.15Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
46.15Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
45.45Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
45.45Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
45.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
45.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
45.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
44.44Single6CM4Risperidone6CM4-D2-Risperidone
44.44Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
44.44Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single8JWY2-1188JWY-A2A-2-118
44.44Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
44.44Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
44.44Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
44.44Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
43.75Single4DAJTiotropium4DAJ-M3-Tiotropium
43.75Single4MQSIperoxo4MQS-M2-Iperoxo
43.75Single4U14Tiotropium4U14-M3-Tiotropium
43.75Single5DHGC-355DHG-NOP-C-35
43.75Single5DHHSB-6121115DHH-NOP-SB-612111
43.75Single5DSGTiotropium5DSG-M4-Tiotropium
43.75Single6TOTLemborexant6TOT-OX1-Lemborexant
43.75Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
43.75Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
43.75Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
43.75Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
43.75Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
43.75Single8CU6LJ-45178CU6-A2A-LJ-4517
43.75Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
43.75Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
43.75Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
43.75Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
43.75Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
43.75Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
43.75Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
43.75Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
43.75Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
43.48Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
43.48Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
42.86Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
42.86Single6HLLCP999946HLL-NK1-CP99994
42.86Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
42.86Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
42.86Single8K5BNiacin8K5B-HCA2-Niacin
42.86Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
42.86Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.86Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
42.86Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
42.86Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
42.86Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.11Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
42.11Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
42.11Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
42.11Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
42.11Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
42.11Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
42.11Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
42.11Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
42.11Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
42.11Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.11Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.11Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
42.11Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
42.11Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
42.11Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
41.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
41.67Single8PWNTheophylline8PWN-A2A-Theophylline
41.67Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
41.18Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
41.18Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
41.18Single5XPRBosentan5XPR-ETB-Bosentan
41.18Single6HLPNetupitant6HLP-NK1-Netupitant
41.18Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
41.18Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
41.18Single6TP6Filorexant6TP6-OX1-Filorexant
41.18Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
41.18Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
41.18Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
41.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
41.18Single7W41PD1762527W41-BB2-PD176252
41.18Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
41.18Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
41.18Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
41.18Single8S4DCMF-0198S4D-Apelin-CMF-019
41.18Single8TF5Oleic acid8TF5-GPR6-Oleic acid
41.18Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
41.18Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
41.18Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
41.18Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
41.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
41.18Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
41.18Consensusbombesin_offOrthosteric Ligandbb2_off
41.18Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
40.91Single6PT2KGCHM076PT2-δ-KGCHM07
40.91Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.91Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
40.91Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.91Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
40.91Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
40.91Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
40.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
40.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
40.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
40.00Single5WS3EMPA5WS3-OX2-EMPA
40.00Single5ZTYAM102575ZTY-CB2-AM10257
40.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
40.00Single6B73MP11046B73-κ-MP1104
40.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
40.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
40.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
40.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
40.00Single7SK9CCX6627SK9-ACKR3-CCX662
40.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
40.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
40.00Single7XN9L-054,5227XN9-SST2-L-054,522
40.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
40.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
40.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
40.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
40.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
40.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
40.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
40.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
40.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
40.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
40.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
40.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
40.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
40.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
40.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
40.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
40.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
40.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
40.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
39.13Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
39.13Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
39.13Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
39.13Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
38.89Single4DJHJDTic4DJH-κ-JDTic
38.89Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
38.89Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
38.89Single6E59L-7607356E59-NK1-L-760735
38.89Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
38.89Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
38.89Single7B6WCyclazosin7B6W-α1b-Cyclazosin
38.89Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
38.89Single7TUYGSK682753A7TUY-GPR183-GSK682753A
38.89Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
38.89Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
38.89Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
38.89Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
38.89Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
38.89Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
38.89Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
38.89Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
38.89Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
38.89Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
38.89Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
38.89Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
38.89Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
38.89Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
38.46Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
38.46Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
38.46Single8A2OTheophylline8A2O-A2A-Theophylline-Na
38.46Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
38.46Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
38.46Consensussensory_onOrthosteric Ligandopsins_on
38.10Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
38.10Single7F8XNN90567F8X-CCKA-NN9056
38.10Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
38.10Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
38.10Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
38.10Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
38.10Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
38.10Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
37.50Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
37.50Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
37.50Single5IU7Q274563465IU7-A2A-Q27456346-Na
37.50Single5IUBQ274563445IUB-A2A-Q27456344-Na
37.50Single5JTBZM-2413855JTB-A2A-ZM-241385
37.50Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
37.50Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
37.50Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
37.50Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
37.50Single6AQFZM-2413856AQF-A2A-ZM-241385
37.50Single6IQLL7458706IQL-D4-L745870
37.50Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
37.50Single6V9SGTPL114036V9S-OX1-GTPL11403
37.50Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
37.50Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
37.50Single7AROLUF58337ARO-A2A-LUF5833-Na
37.50Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
37.50Single7T32ZM-2413857T32-A2A-ZM-241385
37.50Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
37.50Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
37.50Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
37.50Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
37.50Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
37.50Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
37.50Single8K5CAcipimox8K5C-HCA2-Acipimox
37.50Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
37.50Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
37.50Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
37.50Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
37.50Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
37.50Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
37.50Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
37.50Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
37.50Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
37.50Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
37.50Consensusa2_offOrthosteric Liganda2a_off
37.50Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
37.50Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.50Consensushca_onOrthosteric Ligandhca2_on
37.50Consensusopsins_offOrthosteric Ligandrhodopsin_off
37.50Consensussensory_offOrthosteric Ligandopsins_off
37.50Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.04Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.04Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.04Consensusbombesin_onOrthosteric Ligandbb2_on
37.04Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
37.04Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.84Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
36.84Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
36.84Single6A93Risperidone6A93-5-HT2A-Risperidone
36.84Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
36.84Single6ZG4HTL00099366ZG4-M1-HTL0009936
36.84Single7DFPSpiperone7DFP-D2-Spiperone
36.84Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
36.84Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
36.84Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
36.84Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
36.84Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
36.84Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
36.84Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.84Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.84Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
36.84Single8JWZAB9288JWZ-A2A-AB928-Na
36.84Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single8XYIVUF106618XYI-CXCR3-VUF10661
36.84Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
36.84Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
36.84Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
36.84Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
36.84Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
36.84Consensuslpa_offOrthosteric Ligandlpa1_off
36.84Consensusorexin_onOrthosteric Ligandox2_on
36.84Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.84Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.36Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
36.36Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
36.36Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
36.36Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
36.36Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
36.36Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
36.36Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
36.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
36.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
35.71Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
35.71Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
35.71Single6ME5Agomelatine6ME5-MT1-Agomelatine
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
35.71Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
35.71Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
35.71Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
35.71Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
35.71Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
35.71Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
35.71Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.71Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
35.29Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
35.29Single3EMLZM-2413853EML-A2A-ZM-241385
35.29Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
35.29Single5IU8Q274563475IU8-A2A-Q27456347-Na
35.29Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
35.29Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
35.29Single5UENDU1725UEN-A1-DU172
35.29Single5UIGCmpd-15UIG-A2A-Cmpd-1
35.29Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
35.29Single6DRXLisuride6DRX-5-HT2B-Lisuride
35.29Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
35.29Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
35.29Single6S0LZM-2413856S0L-A2A-ZM-241385
35.29Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7PYRPSB-21157PYR-A2A-PSB-2115
35.29Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
35.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
35.29Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
35.29Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
35.29Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
35.29Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
35.29Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
35.29Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
35.29Single8RLNLUF58348RLN-A2A-LUF5834
35.29Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
35.29Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
35.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
35.29Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
35.29Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
35.29Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
35.29Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
35.29Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
35.29Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
35.29Consensushca_on_gpOrthosteric Ligandhca2_on_gp
35.29Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
35.29Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
35.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
35.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
35.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
35.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
35.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
35.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
35.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
35.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
35.00Single8XVJMacitentan8XVJ-ETA-Macitentan
35.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
35.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
35.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
35.00Consensuschemerin_onOrthosteric Ligandcml1_on
35.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
34.78Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
34.78Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
34.78Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
34.78Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Consensusangiotensin_onOrthosteric Ligandat1_on
34.78Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.62Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
34.62Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
34.62Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
34.62Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
34.62Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
33.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
33.33Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
33.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
33.33Single5IUAQ274563485IUA-A2A-Q27456348-Na
33.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
33.33Single5N2RPSB-365N2R-A2A-PSB-36-Na
33.33Single5N2SPSB365N2S-A1-PSB36
33.33Single6D26Fevipiprant6D26-DP2-Fevipiprant
33.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
33.33Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
33.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
33.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
33.33Single6S0QZM-2413856S0Q-A2A-ZM-241385
33.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
33.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
33.33Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
33.33Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
33.33Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
33.33Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
33.33Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
33.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
33.33Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
33.33Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GNEKW-63568GNE-A2A-KW-6356-Na
33.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
33.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
33.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
33.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
33.33Single8QOTNanobody-E8QOT-μ-Nanobody-E
33.33Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
33.33Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
33.33Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
33.33Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
33.33Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
33.33Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
33.33Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
33.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
33.33Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
33.33Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
33.33Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
33.33Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Consensusbradykinin_onOrthosteric Ligandbk2_on
33.33Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
33.33Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
33.33Consensusdp_offOrthosteric Liganddp2_off
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
33.33Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
33.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
33.33Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
33.33Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusvasop-oxy_onOrthosteric Ligandv2_on
33.33Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
32.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
32.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
32.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
31.82Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
31.82Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
31.82Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.82Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
31.82Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Consensuslpl_onOrthosteric Ligands1p_on lpa_on
31.82Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
31.82Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.82Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.58Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
31.58Single5XR8AM8415XR8-CB1-AM841
31.58Single5XRAAM115425XRA-CB1-AM11542
31.58Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
31.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.58Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
31.58Single7PX4PSB-21137PX4-A2A-PSB-2113
31.58Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
31.58Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
31.58Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
31.58Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
31.58Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
31.58Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
31.58Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
31.58Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
31.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.58Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.25Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
31.25Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
31.25Single3PWHZM-2413853PWH-A2A-ZM-241385
31.25Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
31.25Single4S0VSuvorexant4S0V-OX2-Suvorexant
31.25Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
31.25Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
31.25Single6DS0Ly2660976DS0-5-HT2B-Ly266097
31.25Single6ME9Ramelteon6ME9-MT2-Ramelteon
31.25Single6TPJSuvorexant6TPJ-OX2-Suvorexant
31.25Single7F8ULintitript7F8U-CCKA-Lintitript
31.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
31.25Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
31.25Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
31.25Single7XRRLemborexant7XRR-OX2-Lemborexant
31.25Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
31.25Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
31.25Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
31.25Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
31.25Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
31.25Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
31.25Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
31.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.25Single8Y0HVUF114188Y0H-CXCR3-VUF11418
31.25Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.25Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
31.25Consensusangiotensin_offOrthosteric Ligandat1_off
31.25Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.25Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
31.25Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.25Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.77Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
30.77Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
30.77Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
30.77Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
30.77Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
30.77Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
30.77Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
30.43Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
30.43Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.43Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.43Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
30.43Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
30.43Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
30.43Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
30.43Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
30.43Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.43Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.43Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.00Single4N4WSANT-14N4W-SMO-SANT-1
30.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
30.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
30.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
30.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
30.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
30.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
30.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
30.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
30.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
30.00Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
30.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
30.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
30.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
30.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
30.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
30.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
30.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
29.63Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.63Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
29.63Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
29.63Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
29.63Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
29.41Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
29.41Single3REYXAC3REY-A2A-XAC
29.41Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
29.41Single5UVIZM-2413855UVI-A2A-ZM-241385
29.41Single6MH8ZM-2413856MH8-A2A-ZM-241385
29.41Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
29.41Single6TP3Nemorexant6TP3-OX1-Nemorexant
29.41Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
29.41Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
29.41Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.41Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
29.41Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
29.41Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
29.41Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
29.41Single8IHKAcifran8IHK-HCA3-Acifran
29.41Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
29.41Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
29.41Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
29.17Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
29.17Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
29.17Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
29.17Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
29.17Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
28.57Single3RFMCaffeine3RFM-A2A-Caffeine
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single6IGLIRL16206IGL-ETB-IRL1620
28.57Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.57Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
28.57Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
28.57Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
28.57Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
28.57Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
28.57Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
28.57Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
28.57Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
28.57Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
28.57Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
28.57Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
28.57Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
28.57Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
28.57Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
28.57Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
28.57Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.57Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.57Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
28.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
28.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
28.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
28.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
28.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
28.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
27.78Single4YAYZD-71554YAY-AT1-ZD-7155
27.78Single5TGZAM65385TGZ-CB1-AM6538
27.78Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
27.78Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
27.78Single7V3ZCP559407V3Z-CB1-CP55940
27.78Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
27.78Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
27.78Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
27.78Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
27.78Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
27.78Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
27.78Single8K5DGSK2560738K5D-HCA2-GSK256073
27.78Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
27.78Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
27.78Single9IYAONO-97105319IYA-GPR55-ONO-9710531
27.78Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
27.78Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
27.78Consensusblt_onOrthosteric Ligandblt1_on
27.78Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
27.78Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
27.78Consensusleukotriene_onOrthosteric Ligandblt_on
27.78Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
27.78Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
27.59Single5GLHEndothelin-15GLH-ETB-Endothelin-1
27.59Single6IGKEndothelin-36IGK-ETB-Endothelin-3
27.59Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
27.59Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
27.59Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.59Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
27.59Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
27.27Single5EE7MK08935EE7-Glucagon-MK0893
27.27Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
27.27Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
27.27Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8QJ2pN1628QJ2-MC4-pN162-Gs
27.27Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
27.27Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
27.27Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
27.27Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
27.27Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
27.27Consensuskisspeptin_onOrthosteric Ligandkiss1_on
26.92Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
26.92Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
26.92Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.92Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.92Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
26.92Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
26.92Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
26.92Single8ZRTET-18ZRT-ETB-ET-1
26.92Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.92Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
26.67Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
26.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
26.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
26.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
26.67Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.67Consensusgi_sensoryOrthosteric Ligandgi_opsins
26.67Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.67Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.32Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
26.32Single5CGCHTL142425CGC-mGlu5-HTL14242
26.32Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
26.32Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
26.32Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
26.32Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.32Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
26.32Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
26.32Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
26.32Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
26.32Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
26.32Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
26.32Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
26.32Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
26.32Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
26.32Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
26.32Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
26.32Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
26.09Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.09Single7QA8Peptide7QA8-STE2-Peptide
26.09Single7QA8Peptide7QA8-STE2-Peptide
26.09Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
26.09Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
26.09Single8IEBA1LYA8IEB-GPR156-A1LYA
26.09Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.09Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.09Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.09Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
26.09Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.93Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.93Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.93Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
25.93Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.81Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
25.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
25.00Single3OE9IT1t3OE9-CXCR4-IT1t
25.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
25.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
25.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
25.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
25.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
25.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
25.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
25.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
25.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
25.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
25.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
25.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
25.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
25.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
25.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
25.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
25.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
25.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
25.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
25.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
25.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
25.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
25.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
25.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
25.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
25.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
25.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
25.00Single9B9Y7DY9B9Y-CB1-7DY
25.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
25.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
25.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
25.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
25.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
25.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
25.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
25.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
25.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensuslpa_onOrthosteric Ligandlpa1_on
25.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
25.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
25.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
25.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
24.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
24.14Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
24.14Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
24.14Consensusendothelin_onOrthosteric Ligandetb_on eta_on
24.14Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
24.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
24.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
24.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
24.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
24.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
24.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
24.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
23.81Single6KQICP559406KQI-CB1-CP55940-Org27569
23.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81Single7K15MKD0467K15-BLT1-MKD046-Na
23.81Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
23.81Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
23.81Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
23.81Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
23.81Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
23.81Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
23.81Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
23.81Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
23.81Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.53Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
23.53Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
23.53Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.53Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
23.53Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
23.53Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
23.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
23.53Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
23.53Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
23.53Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
23.53Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
23.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
23.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
23.53Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
23.53Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
23.53Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
23.53Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
23.53Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
23.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
23.33Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.08Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
23.08Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
23.08Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
23.08Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
23.08Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
23.08Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
23.08Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
23.08Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
23.08Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.08Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
23.08Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
22.73Single5CGDHTL142425CGD-mGlu5-HTL14242
22.73Single6K1QIRL25006K1Q-ETB-IRL2500
22.73Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
22.73Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
22.73Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
22.73Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
22.58Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
22.58Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
22.58Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
22.58Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
22.22Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
22.22Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
22.22Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
22.22Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
22.22Single6TPKRetosiban6TPK-OT-Retosiban
22.22Single6ZG9GSK10347026ZG9-M1-GSK1034702
22.22Single7VODCariprazine7VOD-5-HT2A-Cariprazine
22.22Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
22.22Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
22.22Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
22.22Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
22.22Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
22.22Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
22.22Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
22.22Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
22.22Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
22.22Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
22.22Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
22.22Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
22.22Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.22Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
22.22Consensusvasop-oxy_offOrthosteric Ligandot_off
21.74Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
21.74Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
21.74Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
21.74Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
21.74Single8IEIA1LYA8IEI-GPR156-A1LYA
21.74Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
21.74Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
21.74Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
21.43Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
21.43Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
21.43Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
21.43Single7WC4Serotonin7WC4-5-HT2A-Serotonin
21.43Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
21.43Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.05Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.05Single6D27CAY104716D27-DP2-CAY10471
21.05Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
21.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
21.05Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
21.05Single6GPSMK08126GPS-CCR2-MK0812
21.05Single6IIVDaltroban6IIV-TP-Daltroban
21.05Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
21.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
21.05Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
21.05Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
21.05Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
21.05Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
21.05Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.83Single4XT1Fractalkine4XT1-US28-Fractalkine
20.83Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.83Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
20.83Single8IEIA1LYA8IEI-GPR156-A1LYA
20.83Single8IEPA1LYA8IEP-GPR156-A1LYA
20.83Single8IEPA1LYA8IEP-GPR156-A1LYA
20.83Single8WKYPG-9348WKY-MC4-PG-934
20.83Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
20.83Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
20.83Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.83Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
20.69Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
20.69Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.69Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
20.69Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
20.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
20.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
20.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
20.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
20.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
20.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
20.00Single7C4SS1P7C4S-S1P3-S1P
20.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
20.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
20.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
20.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
20.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
20.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
20.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
20.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
20.00Consensusep_offOrthosteric Ligandep4_off
20.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
20.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.00Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
19.44Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
19.35Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
19.35Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
19.23Single3OE0CVX153OE0-CXCR4-CVX15
19.23Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single6W25SHU91196W25-MC4-SHU9119-Ca
19.23Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
19.23Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
19.23Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
19.23Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
19.23Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.23Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
19.05Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
19.05Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
19.05Single7P2L4YI7P2L-mGlu5-4YI
19.05Single7R0CAVP7R0C-V2-AVP-Arrestin2
19.05Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
19.05Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
19.05Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
19.05Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
19.05Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
19.05Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
19.05Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.05Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single3OE6IT1t3OE6-CXCR4-IT1t
18.75Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
18.75Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
18.75Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
18.75Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
18.75Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
18.75Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.75Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
18.75Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.75Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.52Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
18.52Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.52Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
18.52Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
18.52Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.52Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
18.52Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
18.52Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
18.52Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
18.52Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
18.18Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.18Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
18.18Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
18.18Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
18.18Single6IIURamatroban6IIU-TP-Ramatroban
18.18Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
18.18Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.18Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
18.18Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
18.18Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
18.18Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
18.18Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.18Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
17.86Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
17.86Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
17.86Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
17.86Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
17.86Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
17.86Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
17.86Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
17.86Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
17.65Single5L7IVismodegib5L7I-SMO-Vismodegib
17.65Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
17.65Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
17.65Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
17.65Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
17.65Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
17.39Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.39Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
17.39Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
17.39Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
17.39Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.39Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
17.39Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
17.39Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single4XT3Fractalkine4XT3-US28-Fractalkine
17.24Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
17.24Single6FJ3PTH6FJ3-PTH1-PTH
17.24Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.24Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.24Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.24Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.24Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
17.24Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
17.24Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
17.24Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
17.24Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
17.14Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.07Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.67Single3ODUIT1t3ODU-CXCR4-IT1t
16.67Single5U09Taranabant5U09-CB1-Taranabant
16.67Single5ZKQABT-4915ZKQ-PAF-ABT-491
16.67Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
16.67Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.67Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
16.67Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
16.67Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
16.67Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.67Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
16.67Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
16.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
16.67Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
16.67Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.67Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
16.67Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
16.67Single9BA0A1AKN9BA0-CB1-A1AKN
16.67Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
16.13Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.13Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
16.13Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.13Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
16.13Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.13Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
16.13Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
16.13Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
16.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
16.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
16.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.79Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
15.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.79Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.79Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
15.79Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
15.79Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.79Consensusgrh_offOrthosteric Ligandgnrh1_off
15.79Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.62Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.38Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
15.38Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
15.38Single7XNACYN1548067XNA-SST2-CYN154806
15.38Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
15.38Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
15.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
15.38Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
15.38Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.38Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.38Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
15.15Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.00Single4QIMANTA XV4QIM-SMO-ANTA XV
15.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.00Single6FFHFenobam6FFH-mGlu5-Fenobam
15.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
15.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
15.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
15.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
15.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.81Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
14.81Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
14.81Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
14.81Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
14.71Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
14.71Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
14.71Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
14.71Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
14.29Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.29Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
14.29Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
14.29Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.29Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
14.29Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
13.79Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.79Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.79Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.79Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.79Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
13.79Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.64Single5TZRMK86665TZR-FFA1-MK8666
13.64Single5V56TC1145V56-SMO-TC114
13.64Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.64Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.64Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
13.64Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.64Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.64Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
13.64Single9BJKNAM9BJK-μ-Naloxone-NAM
13.64Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
13.64Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
13.33Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
13.33Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.33Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
13.33Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
13.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.04Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.04Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.04Single4XEENeurotensin4XEE-NTS1-Neurotensin
13.04Single4XESNeurotensin4XES-NTS1-Neurotensin
13.04Single5X33BIIL2605X33-BLT1-BIIL260
13.04Single6OS2TRV0266OS2-AT1-TRV026
13.04Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
13.04Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.04Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.04Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.04Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.90Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.50Single3OE8IT1t3OE8-CXCR4-IT1t
12.50Single4BUONeurotensin4BUO-NTS1-Neurotensin
12.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.50Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
12.50Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
12.50Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.50Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
12.50Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
12.50Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.12Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
12.00Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
12.00Single8XQJJN2418XQJ-Apelin-JN241
12.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
12.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.76Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.76Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
11.76Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.76Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
11.76Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.76Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.54Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
11.54Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
11.54Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.54Single8KIGSHU91198KIG-MC3-SHU9119-Ca
11.54Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
11.54Consensussomatostatin_offOrthosteric Ligandsst2_off
11.11Single6LI0C176LI0-GPR52-C17
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.11Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
11.11Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
11.11Single7SK5CXCL127SK5-ACKR3-CXCL12
11.11Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
11.11Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.11Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
11.11Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.11Consensusgq_nucleotideOrthosteric Ligandgq_p2y
11.11Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.71Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.53Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.53Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
10.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.53Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.53Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.34Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
10.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single8K2WAMG4878K2W-CXCR3-AMG487
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.68Single7SK3CXCL127SK3-ACKR3-CXCL12
9.52Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.52Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.52Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
9.52Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.52Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.38Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.38Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
9.09Single4JKVTaladegib4JKV-SMO-Taladegib
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.70Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.70Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.70Single5V57TC1145V57-SMO-TC114
8.70Single6OS1TRV0266OS1-AT1-TRV026
8.70Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.70Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
8.70Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
8.70Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusneurotensin_onOrthosteric Ligandnts1_on
8.70Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.70Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.33Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
8.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
8.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
8.33Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.33Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Single8XQJJN2418XQJ-Apelin-JN241
8.33Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.33Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
8.33Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
8.33Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
8.33Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.33Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.33Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
8.33Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.33Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.11Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
8.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
8.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
8.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
8.00Single8XVUCXCL28XVU-CXCR2-CXCL2
8.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
8.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single6KNMJN241-96KNM-Apelin-JN241-9
7.69Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
7.69Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7.69Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.69Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
7.41Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
7.41Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
7.41Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single8XWNCXCL88XWN-CXCR2-CXCL8
7.14Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
7.14Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
6.25Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.25Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.88Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.88Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.88Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off
5.56Single4XNWMRS25004XNW-P2Y1-MRS2500
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.56Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.56Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.56Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.56Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.26Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.26Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
5.26Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.26Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
5.00Single4QINSAG1.54QIN-SMO-SAG1.5
5.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
5.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
5.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
5.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
5.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.76Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.76Single6ZINSR486926ZIN-NTS1-SR48692
4.76Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
4.76Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8IYXYL-3658IYX-GPR34-YL-365
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.55Single5T04Neurotensin5T04-NTS1-Neurotensin
4.55Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.55Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.55Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.55Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.55Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.55Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.55Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.35Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.35Single6Z4SSR486926Z4S-NTS1-SR48692
4.35Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.35Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
4.35Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.17Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
4.17Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
4.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8XWACXCL18XWA-CXCR2-CXCL1
4.00Single8XWMCXCL68XWM-CXCR2-CXCL6
4.00Single8XWSCXCL58XWS-CXCR2-CXCL5
4.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single8XWFCXCL38XWF-CXCR2-CXCL3
3.85Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.70Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.57Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
gs_5ht 7XTC-5-HT7-5-CT-Gs/β1/γ2
7XTB-5-HT6-Serotonin-Gs/β1/γ2
8JLZ-5-HT6-ST1936-Gs/β1/γ2
7XT8-5-HT4-Serotonin-Gs/β1/γ2
gs_adrenergic 7DHI-β2-Salbutamol-Gs/β1/γ2
7XJI-β3-Solabegron-Gs/β1/γ2
7JJO-β1-Isoprenaline-Gs/β1/γ2
6NI3-β2-BI167107-Gs/β1/γ2
8DCR-β1-Dobutamine-Gs/β1/γ2
7XJH-β3-Isoproterenol-Gs/β1/γ2
7DH5-β3-Mirabegron-Gs/β1/γ2
gs_dopamine 7F0T-D1-Dopamine-Gs/β1/γ2
7CKW-D1-Fenoldopam-Gs/β1/γ2
7CKY-D1-PW0464-Gs/β1/γ2
8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8IRR-D1-Rotigotine-Gs/β1/γ2
7JV5-D1-SKF81297-Gs/β1/γ2
7JVP-D1-SKF83959-Gs/β1/γ2
7X2D-D1-Tavapadon-Gs/β1/γ2
7CKX-D1-A77636-Gs/β1/γ2
7JVQ-D1-Apomorphine-Gs/β1/γ2
gs_histamine 8POK-H2-Histamine-Gs/β1/γ2
gs_trace-amine 8W88-TA1-SEP-363856-Gs/β1/γ2
8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
8JLO-TA1-Ulotaront-Gs/β1/γ2
8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
8JLP-TA1-Ralmitaront-Gs/β1/γ2
8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
Net Summary
Imin 2.86465
Number of Linked Nodes 947
Number of Links 1105
Number of Hubs 172
Number of Links mediated by Hubs 664
Number of Communities 23
Number of Nodes involved in Communities 209
Number of Links involved in Communities 303
Path Summary
Number Of Nodes in MetaPath 110
Number Of Links MetaPath 109
Number of Shortest Paths 4348272
Length Of Smallest Path 3
Average Path Length 45.7619
Length of Longest Path 71
Minimum Path Strength 0.231077
Average Path Strength 5.84137
Maximum Path Strength 18.9793
Minimum Path Correlation 0.703249
Average Path Correlation 0.980123
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.51515
Average % Of Corr. Nodes 25.5002
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.5755
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_class-ags_peptide
gs_nucleotide
gs_amine



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_amine.zip



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