Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.63361110
2R:R:Y9 11.1375405
3R:R:E13 9.134536
4R:R:N24 7.6875409
5R:R:N34 9.95426
6R:R:L37 7.158528
7R:R:F44 5.22407
8R:R:V55 4.878536
9R:R:I60 5.67667636
10R:R:F70 5.7525407
11R:R:I80 5.5075416
12R:R:F83 6.675415
13R:R:L85 4.7925414
14R:R:Q89 8.1975415
15R:R:I92 3.985407
16R:R:F93 5.8025415
17R:R:D101 6.796549
18R:R:I104 3.68545
19R:R:Y112 7.545447
20R:R:V116 6.43547
21R:R:P139 7.6925415
22R:R:W143 9.3225415
23R:R:N144 5.385484
24R:R:C166 5.55419
25R:R:F168 13.6475414
26R:R:E169 7.2025413
27R:R:P173 7.0525414
28R:R:Y176 8.95714716
29R:R:M177 4.54716
30R:R:V178 5.77415
31R:R:N181 5.8725415
32R:R:F182 8.494515
33R:R:F183 5.0225414
34R:R:I200 3.34409
35R:R:F201 4.205405
36R:R:F242 7.692519
37R:R:W246 8.654518
38R:R:H250 10.6675416
39R:R:F257 9.22413
40R:R:F258 6.136516
41R:R:H278 6.556536
42R:R:N284 5.016509
43R:R:P285 5.5625409
44R:R:I287 4.5975468
45R:R:Y288 5.438529
46R:R:R291 7.33567
47R:R:E294 6.5625426
48R:R:F295 7.39167628
49R:R:T298 5.2575427
50R:R:F299 5.89406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:I274 13.084514.74YesNo004
2L:L:?1 R:R:W246 15.09836.53YesYes108
3R:R:H278 R:R:I60 13.115710.61YesYes366
4L:L:?1 R:R:V84 60.37575.13YesNo006
5R:R:A59 R:R:V84 60.34113.39NoNo066
6R:R:A59 R:R:V55 60.3485.09NoYes066
7R:R:S281 R:R:V55 1008.08NoYes096
8R:R:D52 R:R:S281 97.33810.31NoNo099
9R:R:D52 R:R:N24 10.82813.46NoYes099
10R:R:D52 R:R:N284 88.47188.08NoYes099
11R:R:N284 R:R:Y288 63.10013.49YesYes099
12R:R:F295 R:R:Y288 61.87656.19YesYes289
13R:R:F295 R:R:F299 14.75518.57YesYes086
14R:R:F295 R:R:L37 16.997712.18YesYes288
15R:R:F295 R:R:N42 31.29187.25YesNo288
16R:R:N39 R:R:N42 31.773613.62NoNo078
17R:R:N39 R:R:T41 30.67482.92NoNo078
18R:R:D101 R:R:T41 27.274610.12YesNo498
19L:L:?1 R:R:M177 26.97314.87YesYes106
20R:R:M177 R:R:Y176 22.43943.59YesYes166
21R:R:F180 R:R:Y176 17.843412.38NoYes146
22R:R:C185 R:R:F180 17.27842.79NoNo154
23R:R:C185 R:R:Q89 15.41377.63NoYes155
24R:R:Q89 R:R:S132 10.67215.78YesNo157
25R:R:F242 R:R:W246 14.585316.04YesYes198
26R:R:L87 R:R:V55 25.34054.47NoYes076
27L:L:?1 R:R:I66 26.66466.55YesNo104
28R:R:F62 R:R:I80 20.127611.3NoYes156
29R:R:F62 R:R:F83 19.53836.43NoYes155
30R:R:C166 R:R:I66 23.0463.27YesNo194
31R:R:C166 R:R:F70 16.1528.38YesYes097
32R:R:F70 R:R:T68 17.39633.89YesNo075
33R:R:G69 R:R:T68 15.46911.82NoNo045
34R:R:C166 R:R:C77 19.69437.28YesNo099
35R:R:C77 R:R:V171 18.453.42NoNo094
36R:R:C74 R:R:V171 17.35473.42NoNo034
37R:R:C74 R:R:V164 16.16246.83NoNo034
38R:R:P149 R:R:V164 14.72741.77NoNo054
39R:R:E151 R:R:P149 10.38096.29NoNo025
40L:L:?1 R:R:H250 16.00295.9YesYes106
41R:R:I238 R:R:N284 36.67465.66NoYes089
42R:R:I238 R:R:I287 35.59327.36NoYes088
43R:R:I287 R:R:R291 31.20173.76YesYes687
44R:R:K233 R:R:R291 28.27292.48NoYes077
45R:R:F201 R:R:K233 25.01826.2YesNo057
46R:R:F201 R:R:I200 21.70122.51YesYes059
47R:R:I106 R:R:I200 11.02912.94NoYes089
48R:R:F257 R:R:M174 10.23537.46YesNo034
49R:R:F182 R:R:H250 10.93226.02YesYes156
50R:R:F83 R:R:L87 23.82249.74YesNo057
51R:R:I60 R:R:V55 18.87983.07YesYes366
52R:R:H278 R:R:S277 10.03434.18YesNo067
53R:R:C166 R:R:I80 12.32543.27YesYes196
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:I66 6.55 1 Yes No 0 4 0 1
L:L:?1 R:R:V84 5.13 1 Yes No 0 6 0 1
L:L:?1 R:R:F168 37.73 1 Yes Yes 0 4 0 1
L:L:?1 R:R:E169 5.32 1 Yes Yes 0 3 0 1
L:L:?1 R:R:M177 4.87 1 Yes Yes 0 6 0 1
L:L:?1 R:R:W246 6.53 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L249 15.88 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 5.9 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 9.45 1 Yes No 0 5 0 1
L:L:?1 R:R:M270 4.87 1 Yes No 0 4 0 1
L:L:?1 R:R:I274 14.74 1 Yes No 0 4 0 1
R:R:I274 R:R:Y9 3.63 0 No Yes 4 5 1 2
R:R:A59 R:R:V84 3.39 0 No No 6 6 2 1
R:R:I66 R:R:I80 4.42 1 No Yes 4 6 1 2
R:R:C166 R:R:I66 3.27 1 Yes No 9 4 2 1
R:R:C166 R:R:I80 3.27 1 Yes Yes 9 6 2 2
R:R:L85 R:R:Y176 3.52 1 Yes Yes 4 6 2 2
R:R:L85 R:R:M177 4.24 1 Yes Yes 4 6 2 1
R:R:L85 R:R:N181 8.24 1 Yes Yes 4 5 2 2
R:R:F168 R:R:V172 7.87 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
R:R:E169 R:R:M174 6.77 1 Yes No 3 4 1 2
R:R:E169 R:R:T256 5.64 1 Yes No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 Yes No 3 2 1 2
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 5.81 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 5.61 1 Yes Yes 6 5 1 2
R:R:M177 R:R:N253 4.21 1 Yes No 6 5 1 1
R:R:H250 R:R:N181 3.83 1 Yes Yes 6 5 1 2
R:R:F182 R:R:V186 3.93 1 Yes No 5 7 2 2
R:R:F182 R:R:H250 26.02 1 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 1 Yes No 6 7 1 2
R:R:F242 R:R:W246 16.04 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 7.25 1 Yes No 9 9 2 2
R:R:S277 R:R:W246 13.59 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 4.52 1 No Yes 9 8 2 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
R:R:H264 R:R:T256 12.32 1 No No 2 4 2 2
R:R:H264 R:R:M270 5.25 1 No No 2 4 2 1
R:R:H278 R:R:I274 3.98 3 Yes No 6 4 2 1
R:R:H278 R:R:S277 4.18 3 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
R:R:A88 R:R:W246 2.59 0 No Yes 6 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
83.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
81.82Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
76.92Single5N2SPSB365N2S-A1-PSB36
76.92Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
76.92Single8GNEKW-63568GNE-A2A-KW-6356-Na
76.92Consensusadenosine_offOrthosteric Liganda1_off a2_off
75.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
75.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
75.00Single5JTBZM-2413855JTB-A2A-ZM-241385
75.00Single6AQFZM-2413856AQF-A2A-ZM-241385
75.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
75.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
75.00Consensusa2_offOrthosteric Liganda2a_off
75.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
71.43Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
69.23Single3EMLZM-2413853EML-A2A-ZM-241385
69.23Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
69.23Single5IU8Q274563475IU8-A2A-Q27456347-Na
69.23Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
69.23Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
69.23Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
69.23Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
69.23Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
69.23Single6S0LZM-2413856S0L-A2A-ZM-241385
69.23Single7PYRPSB-21157PYR-A2A-PSB-2115
66.67Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
66.67Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
66.67Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
64.29Single5IUAQ274563485IUA-A2A-Q27456348-Na
64.29Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
64.29Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
64.29Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
64.29Single6S0QZM-2413856S0Q-A2A-ZM-241385
64.29Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
64.29Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
64.29Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
64.29Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
61.54Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
61.54Single5IUBQ274563445IUB-A2A-Q27456344-Na
61.54Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
61.54Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
61.54Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
61.54Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
61.54Single5UVIZM-2413855UVI-A2A-ZM-241385
61.54Single6MH8ZM-2413856MH8-A2A-ZM-241385
61.54Single7AROLUF58337ARO-A2A-LUF5833-Na
61.54Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
61.54Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
60.00Single7PX4PSB-21137PX4-A2A-PSB-2113
60.00Consensusa2_onOrthosteric Liganda2b_on
60.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
60.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
60.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
60.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
60.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
58.82Single3NY9ICI118-5513NY9-β2-ICI118-551
58.33Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
58.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
58.33Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
58.33Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
57.14Single5UENDU1725UEN-A1-DU172
57.14Single5UIGCmpd-15UIG-A2A-Cmpd-1
57.14Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
57.14Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
57.14Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
57.14Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
57.14Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
57.14Single9CHXS-Carazolol9CHX-β2-S-Carazolol
57.14Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
56.25Single8JWY2-1188JWY-A2A-2-118
55.56Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
54.55Single3RFMCaffeine3RFM-A2A-Caffeine
54.55Single8A2OTheophylline8A2O-A2A-Theophylline-Na
53.85Single3PWHZM-2413853PWH-A2A-ZM-241385
53.85Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
53.85Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
53.85Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
53.85Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
53.85Single8GNGIstradefylline8GNG-A2A-Istradefylline
53.85Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
53.85Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
53.85Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
53.85Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
53.85Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
53.85Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
53.33Single5N2RPSB-365N2R-A2A-PSB-36-Na
53.33Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
53.33Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
53.33Single7W41PD1762527W41-BB2-PD176252
53.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
53.33Single8QOTNanobody-E8QOT-μ-Nanobody-E
53.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
53.33Consensusbombesin_offOrthosteric Ligandbb2_off
52.63Single3QAKUK-4320973QAK-A2A-UK-432097
50.00Single2YDOAdenosine2YDO-A2A-Adenosine
50.00Single2YDVNECA2YDV-A2A-NECA
50.00Single3REYXAC3REY-A2A-XAC
50.00Single3UZAGTPL92363UZA-A2A-GTPL9236
50.00Single4UG2CGS216804UG2-A2A-CGS21680
50.00Single4UHRCGS216804UHR-A2A-CGS21680
50.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
50.00Single5G53NECA5G53-A2A-NECA-Gs
50.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
50.00Single6J21Aprepitant6J21-NK1-Aprepitant
50.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
50.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
50.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
50.00Single7T32ZM-2413857T32-A2A-ZM-241385
50.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
50.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
50.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
50.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
50.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
50.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
50.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
50.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
50.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
50.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
50.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
50.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
50.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
50.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
50.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
50.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
47.37Single7F8XNN90567F8X-CCKA-NN9056
47.37Single8WDTphotoNECA8WDT-A2A-photoNECA
47.37Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
47.37Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
47.06Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
47.06Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
47.06Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
47.06Single7YITNalfurafine7YIT-κ-Nalfurafine
47.06Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
47.06Single8JJLOlodaterol8JJL-β2-Olodaterol
47.06Single8JWZAB9288JWZ-A2A-AB928-Na
47.06Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
47.06Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
47.06Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
47.06Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
47.06Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
47.06Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
46.67Single3NY8ICI118-5513NY8-β2-ICI118-551
46.67Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
46.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
46.67Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
46.67Single4GBRS-Carazolol4GBR-β2-S-Carazolol
46.67Single6PS1Timolol6PS1-β2-Timolol
46.67Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
46.67Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
46.67Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
46.67Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
46.67Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
46.67Single8JJOAlprenolol8JJO-β2-Alprenolol
46.67Single8RLNLUF58348RLN-A2A-LUF5834
46.67Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
46.67Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
46.67Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
46.67Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
46.67Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
46.67Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
46.67Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
46.67Consensusa3_onOrthosteric Liganda3a_on
46.67Consensusdopamine_offOrthosteric Ligandd2_off d3_off
46.15Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
46.15Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
46.15Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
46.15Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
45.45Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
45.45Single8PWNTheophylline8PWN-A2A-Theophylline
45.00Single6HLOAprepitant6HLO-NK1-Aprepitant
45.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
44.44Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
44.44Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
44.44Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
44.44Single7EZCUKA7EZC-A2A-UKA
44.44Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
44.44Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
44.44Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
44.44Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
44.44Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
44.44Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
44.44Consensuscck_onOrthosteric Ligandccka_on cckb_on
44.44Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
44.44Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
44.44Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
44.44Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
43.75Single2RH1S-Carazolol2RH1-β2-S-Carazolol
43.75Single2YCWS-Carazolol2YCW-β1-S-Carazolol
43.75Single5D6LS-Carazolol5D6L-β2-S-Carazolol
43.75Single6LUQHaloperidol6LUQ-D2-Haloperidol
43.75Single6PS6Timolol6PS6-β2-Timolol
43.75Single7C61Ergotamine7C61-5-HT1B-Ergotamine
43.75Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
43.75Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
43.75Single7SINNPS-21437SIN-CaS-NPS-2143
43.75Single7SINNPS-21437SIN-CaS-NPS-2143
43.75Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
43.75Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
43.75Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
43.75Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
43.75Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
43.75Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
43.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
43.75Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
43.75Consensusa3_on_gpOrthosteric Liganda3a_on_gp
43.75Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
43.75Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
43.75Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
43.75Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
43.75Consensusamine_offonOrthosteric Ligandamine_off amine_on
43.75Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
43.75Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
43.75Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
43.75Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
43.75Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
43.75Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
43.75Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
43.75Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
43.75Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
43.75Consensustrace-amine_onOrthosteric Ligandta1_on
42.86Single5WF5UK-4320975WF5-A2A-UK-432097
42.86Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
42.86Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
42.86Single6PT2KGCHM076PT2-δ-KGCHM07
42.86Single7F8ULintitript7F8U-CCKA-Lintitript
42.86Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
42.86Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
42.86Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
42.86Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.86Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
42.86Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
42.86Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensusalpha2_offOrthosteric Ligandalpha2c_off
42.86Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
42.86Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
42.86Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
42.86Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
42.11Single5WF6UK-4320975WF6-A2A-UK-432097
42.11Single6PT3DPI-2876PT3-δ-DPI-287
42.11Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
42.11Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
42.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
42.11Single8QJ2pN1628QJ2-MC4-pN162-Gs
42.11Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
41.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
41.18Single3P0GBI1671073P0G-β2-BI167107
41.18Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
41.18Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
41.18Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
41.18Single5D5AS-Carazolol5D5A-β2-S-Carazolol
41.18Single5D5BS-Carazolol5D5B-β2-S-Carazolol
41.18Single6J20Aprepitant6J20-NK1-Aprepitant
41.18Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
41.18Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
41.18Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
41.18Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
41.18Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
41.18Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
41.18Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
41.18Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
41.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
41.18Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
41.18Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
41.18Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
41.18Single8XVLZibotentan8XVL-ETA-Zibotentan
41.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
41.18Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
41.18Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
41.18Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
41.18Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
41.18Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
41.18Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
41.18Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
41.18Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
41.18Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
41.18Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
41.18Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.18Consensustachykinin_offOrthosteric Ligandnk1_off
41.18Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
40.91Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
40.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
40.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
40.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
40.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
40.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
40.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
40.00Single6PS4ICI118-5516PS4-β2-ICI118-551
40.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
40.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
40.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
40.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
40.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
40.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
40.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
40.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
40.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
40.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
40.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
40.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
40.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
40.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
40.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
40.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
40.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
40.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
40.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
40.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
40.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
40.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
40.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
40.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
40.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
40.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
40.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
39.13Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.13Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
39.13Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Single3D4STimolol3D4S-β2-Timolol
38.89Single4AMIBucindolol4AMI-β1-Bucindolol
38.89Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
38.89Single4RWADIPP-NH24RWA-δ-DIPP-NH2
38.89Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
38.89Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
38.89Single6MXTSalmeterol6MXT-β2-Salmeterol
38.89Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
38.89Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
38.89Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
38.89Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
38.89Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
38.89Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.89Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
38.89Single8JJ8Formoterol8JJ8-β2-Formoterol
38.89Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
38.89Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
38.89Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
38.89Consensuslpa_offOrthosteric Ligandlpa1_off
38.89Consensuslpl_offOrthosteric Ligands1p_off lpa_off
38.89Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
38.89Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
38.89Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
38.46Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
38.46Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
38.46Consensusgi_sensoryOrthosteric Ligandgi_opsins
38.46Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
38.46Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
38.10Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
38.10Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.10Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
38.10Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.10Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.10Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
37.50Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
37.50Single2Y02Carmoterol2Y02-β1-Carmoterol
37.50Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
37.50Single4EJ4Naltrindole4EJ4-δ-Naltrindole
37.50Single6D27CAY104716D27-DP2-CAY10471
37.50Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
37.50Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
37.50Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
37.50Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
37.50Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
37.50Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
37.50Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
37.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
37.50Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
37.50Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
37.50Single7WC7Lisuride7WC7-5-HT2A-Lisuride
37.50Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.50Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
37.50Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
37.50Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
37.50Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
37.50Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
37.50Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
37.50Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
37.50Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
37.50Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
37.50Single8JXRLSD8JXR-D1-LSD
37.50Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
37.50Single8T1WCVN4248T1W-GPR6-CVN424
37.50Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
37.50Single8X63Mepyramine8X63-H1-Mepyramine
37.50Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
37.50Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
37.50Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
37.50Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
37.50Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
37.50Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
37.50Consensus5ht5_onOrthosteric Ligand5ht5a_on
37.50Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
37.50Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
37.50Consensusalpha2_onOrthosteric Ligandalpha2b_on
37.50Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
37.50Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
37.50Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
37.50Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
37.50Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
37.50Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
37.50Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
37.50Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
37.50Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
37.50Consensushistamine_offOrthosteric Ligandh1_off
37.50Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
37.50Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
37.50Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
36.84Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
36.84Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
36.84Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.84Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
36.84Single6H7LDobutamine6H7L-β1-Dobutamine
36.84Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
36.84Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
36.84Single7UM4AS26747237UM4-5-HT5A-AS2674723
36.84Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
36.84Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
36.84Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
36.84Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
36.84Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.84Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.84Consensusendothelin_offOrthosteric Ligandetb_off
36.84Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
36.84Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
36.84Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
36.36Single5MZPCaffeine5MZP-A2A-Caffeine-Na
36.36Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
36.36Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
36.36Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
36.36Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
36.36Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
36.36Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
35.71Single3OE9IT1t3OE9-CXCR4-IT1t
35.71Single3PBLEticlopride3PBL-D3-Eticlopride
35.71Single6HLLCP999946HLL-NK1-CP99994
35.71Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
35.71Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
35.71Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
35.71Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
35.71Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
35.71Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
35.71Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
35.71Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
35.71Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
35.29Single2Y00Dobutamine2Y00-β1-Dobutamine
35.29Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
35.29Single5C1MBU725C1M-μ-BU72
35.29Single5JQHS-Carazolol5JQH-β2-S-Carazolol
35.29Single5TVNLSD5TVN-5-HT2B-LSD
35.29Single5XPRBosentan5XPR-ETB-Bosentan
35.29Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
35.29Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
35.29Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.29Single6E67BI1671076E67-β2-BI167107-Gs (fused)
35.29Single6HLPNetupitant6HLP-NK1-Netupitant
35.29Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
35.29Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
35.29Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
35.29Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
35.29Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
35.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
35.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
35.29Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
35.29Single7WC6LSD7WC6-5-HT2A-LSD
35.29Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
35.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
35.29Single8S4DCMF-0198S4D-Apelin-CMF-019
35.29Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
35.29Single8TF5Oleic acid8TF5-GPR6-Oleic acid
35.29Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
35.29Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
35.29Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
35.29Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
35.29Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
35.29Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
35.29Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
35.29Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
35.29Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
35.29Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
35.29Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
35.29Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
35.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
35.29Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
35.29Consensusdp_offOrthosteric Liganddp2_off
35.29Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
35.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
35.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
35.00Single7XN9L-054,5227XN9-SST2-L-054,522
35.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
35.00Single8X5YAstemizole8X5Y-H1-Astemizole
35.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
35.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
34.78Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
34.78Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
34.78Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
33.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
33.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
33.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
33.33Single6E59L-7607356E59-NK1-L-760735
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
33.33Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
33.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
33.33Single6WGTLSD6WGT-5-HT2A-LSD
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
33.33Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
33.33Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
33.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
33.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
33.33Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
33.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
33.33Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
33.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
33.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
33.33Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
33.33Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
33.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
33.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
33.33Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
33.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
33.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
33.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
33.33Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
33.33Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
33.33Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
33.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
33.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
33.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
33.33Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
33.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
33.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
33.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
33.33Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
33.33Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
33.33Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
33.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
33.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
33.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
33.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
33.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
33.33Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusbombesin_onOrthosteric Ligandbb2_on
33.33Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
33.33Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
33.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
33.33Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
33.33Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
33.33Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
33.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
33.33Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
33.33Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.14Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
32.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
32.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
32.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
32.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
31.82Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
31.82Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.82Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
31.82Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
31.82Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
31.82Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.82Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
31.82Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.82Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.82Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.58Single4LDEBI1671074LDE-β2-BI167107
31.58Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
31.58Single6A93Risperidone6A93-5-HT2A-Risperidone
31.58Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
31.58Single6CM4Risperidone6CM4-D2-Risperidone
31.58Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
31.58Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
31.58Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
31.58Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
31.58Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
31.58Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
31.58Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
31.58Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
31.58Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
31.58Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
31.58Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.58Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
31.58Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
31.58Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
31.58Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
31.58Consensusalpha1_offOrthosteric Ligandalpha1a_off
31.58Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
31.58Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
31.58Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
31.58Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
31.58Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
31.58Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.58Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.25Single3RZECidoxepin3RZE-H1-Cidoxepin
31.25Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
31.25Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
31.25Single6A94Zotepine6A94-5-HT2A-Zotepine
31.25Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
31.25Single6IQLL7458706IQL-D4-L745870
31.25Single6KUXRS-799486KUX-α2a-RS-79948
31.25Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.25Single6TPGEMPA6TPG-OX2-EMPA
31.25Single6TPKRetosiban6TPK-OT-Retosiban
31.25Single6TPNHTL66416TPN-OX2-HTL6641
31.25Single6V9SGTPL114036V9S-OX1-GTPL11403
31.25Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
31.25Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
31.25Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
31.25Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
31.25Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
31.25Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
31.25Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
31.25Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
31.25Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.25Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
31.25Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
31.25Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
31.25Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
31.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
31.25Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
31.25Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9BJKNaloxone9BJK-μ-Naloxone-NAM
31.25Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
31.25Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
31.25Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
31.25Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
31.25Consensusopsins_offOrthosteric Ligandrhodopsin_off
31.25Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
31.25Consensussensory_offOrthosteric Ligandopsins_off
31.25Consensusvasop-oxy_offOrthosteric Ligandot_off
30.77Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
30.77Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
30.77Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
30.77Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
30.77Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
30.77Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
30.77Single9CHUNoradrenaline9CHU-β2-Noradrenaline
30.77Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
30.77Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
30.77Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
30.77Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
30.77Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
30.77Consensussensory_onOrthosteric Ligandopsins_on
30.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.43Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
30.43Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
30.43Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
30.43Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
30.43Consensusangiotensin_onOrthosteric Ligandat1_on
30.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.00Single5X93K-87945X93-ETB-K-8794
30.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
30.00Single6IBLArformoterol6IBL-β1-Arformoterol
30.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
30.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
30.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
30.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
30.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
30.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
30.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
30.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
30.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
30.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
30.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
30.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
29.63Single6IGLIRL16206IGL-ETB-IRL1620
29.63Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
29.63Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
29.63Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
29.63Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
29.63Consensusbradykinin_onOrthosteric Ligandbk2_on
29.63Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
29.63Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
29.63Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
29.63Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
29.41Single2Y01Dobutamine2Y01-β1-Dobutamine
29.41Single2Y04Salbutamol2Y04-β1-Salbutamol
29.41Single4DAJTiotropium4DAJ-M3-Tiotropium
29.41Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
29.41Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
29.41Single4MQSIperoxo4MQS-M2-Iperoxo
29.41Single4QKX35V4QKX-β2-35V
29.41Single4U14Tiotropium4U14-M3-Tiotropium
29.41Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
29.41Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
29.41Single5DHHSB-6121115DHH-NOP-SB-612111
29.41Single5TGZAM65385TGZ-CB1-AM6538
29.41Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
29.41Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
29.41Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
29.41Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
29.41Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
29.41Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
29.41Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
29.41Single6H7MSalbutamol6H7M-β1-Salbutamol
29.41Single6TOTLemborexant6TOT-OX1-Lemborexant
29.41Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
29.41Single7BU7BI1671077BU7-β1-BI167107
29.41Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
29.41Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
29.41Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
29.41Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
29.41Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
29.41Single7UL4Alvimopan7UL4-μ-Alvimopan
29.41Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
29.41Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
29.41Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
29.41Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
29.41Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
29.41Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
29.41Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
29.41Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
29.41Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
29.41Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
29.41Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
29.41Single8X64Desloratadine8X64-H1-Desloratadine
29.41Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
29.41Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
29.41Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
29.41Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
29.41Consensuscck_offOrthosteric Ligandccka_off
29.41Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
29.41Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
29.41Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
29.17Single6JODAngiotensin II6JOD-AT2-Angiotensin II
29.17Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
29.17Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.17Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.17Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
29.17Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
29.17Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
29.17Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
29.17Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.17Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
29.17Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.57Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
28.57Single3OE6IT1t3OE6-CXCR4-IT1t
28.57Single5GLHEndothelin-15GLH-ETB-Endothelin-1
28.57Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
28.57Single5ZTYAM102575ZTY-CB2-AM10257
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.57Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
28.57Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
28.57Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
28.57Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
28.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
28.57Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
28.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
28.57Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
28.57Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
28.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
28.57Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
28.57Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
28.57Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
28.57Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
28.57Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
28.57Consensus5ht2_onOrthosteric Ligand5ht2b_on
28.57Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
28.57Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
28.57Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
28.57Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
28.57Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.57Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
28.57Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
28.57Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
28.57Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
28.57Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
28.57Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
28.57Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
28.57Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
28.57Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.57Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
28.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
28.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
28.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
28.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
28.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8ZRTET-18ZRT-ETB-ET-1
28.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
28.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
28.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
28.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
27.78Single2Y03Isoprenaline2Y03-β1-Isoprenaline
27.78Single5WIUNemonapride5WIU-D4-Nemonapride
27.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
27.78Single5WQCEMPA5WQC-OX2-EMPA
27.78Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
27.78Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
27.78Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.78Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
27.78Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
27.78Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
27.78Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
27.78Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
27.78Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
27.78Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.78Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
27.78Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
27.78Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
27.78Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
27.78Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
27.78Single8JXSPF-61428JXS-D1-PF-6142
27.78Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
27.78Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
27.78Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
27.78Single8ZMFA1L108ZMF-5-HT2C-A1L10
27.78Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
27.78Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
27.78Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.78Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
27.78Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.78Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.59Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
27.59Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
27.59Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
27.59Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
27.27Single4XT1Fractalkine4XT1-US28-Fractalkine
27.27Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
27.27Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.27Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
27.27Single8WKYPG-9348WKY-MC4-PG-934
27.27Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
27.27Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.27Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.27Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.27Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.92Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
26.92Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
26.67Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
26.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
26.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
26.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
26.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
26.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
26.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
26.67Single7SRQLSD7SRQ-5-HT2B-LSD
26.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
26.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
26.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
26.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
26.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
26.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
26.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
26.67Single8K5BNiacin8K5B-HCA2-Niacin
26.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
26.67Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
26.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single9B9Y7DY9B9Y-CB1-7DY
26.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
26.67Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
26.67Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
26.32Single4U15Tiotropium4U15-M3-Tiotropium
26.32Single5XRAAM115425XRA-CB1-AM11542
26.32Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
26.32Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
26.32Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
26.32Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
26.32Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
26.32Single6OL9Tiotropium6OL9-M5-Tiotropium
26.32Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.32Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
26.32Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.32Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
26.32Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
26.32Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
26.32Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
26.32Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
26.32Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
26.32Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Single8EA0Iperoxo8EA0-M3-Iperoxo
26.32Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
26.32Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
26.32Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
26.32Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.32Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
26.32Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
26.32Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
26.32Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
26.32Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.32Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
26.32Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
26.32Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
26.32Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.32Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.32Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
26.32Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
26.32Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
26.32Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
26.32Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
26.32Consensuslpa_onOrthosteric Ligandlpa1_on
26.32Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
26.32Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
26.32Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
26.32Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
26.32Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
26.32Consensusrelaxin_onOrthosteric Ligandrxfp4_on
26.32Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
26.09Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
26.09Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.09Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
26.09Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
26.09Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
26.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
26.09Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.09Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.09Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.09Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.09Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.93Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.93Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
25.93Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
25.93Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
25.81Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
25.00Single3ODUIT1t3ODU-CXCR4-IT1t
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
25.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
25.00Single5CXVTiotropium5CXV-M1-Tiotropium
25.00Single5WS3EMPA5WS3-OX2-EMPA
25.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
25.00Single6KQICP559406KQI-CB1-CP55940-Org27569
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6OS2TRV0266OS2-AT1-TRV026
25.00Single6TODEMPA6TOD-OX1-EMPA-Na
25.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
25.00Single6W25SHU91196W25-MC4-SHU9119-Ca
25.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
25.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
25.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
25.00Single7DFPSpiperone7DFP-D2-Spiperone
25.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
25.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
25.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
25.00Single7K15MKD0467K15-BLT1-MKD046-Na
25.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
25.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
25.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
25.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
25.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
25.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
25.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
25.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
25.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
25.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
25.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
25.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
25.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
25.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
25.00Single8IWESpermidine8IWE-TA9-Spermidine
25.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
25.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
25.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
25.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
25.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
25.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
25.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
25.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
25.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
25.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
25.00Single8XYIVUF106618XYI-CXCR3-VUF10661
25.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
25.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
25.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
25.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
25.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
25.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
25.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
25.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
25.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
25.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
25.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
25.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
25.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
25.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
25.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
25.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
25.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
25.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
25.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
25.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.14Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
24.14Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
24.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
24.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
24.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
24.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
24.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
24.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
24.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
24.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
24.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
24.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
23.81Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
23.81Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
23.81Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
23.81Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
23.81Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
23.81Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
23.81Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
23.81Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
23.81Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
23.81Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
23.81Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
23.81Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
23.81Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
23.81Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
23.81Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.81Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
23.53Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
23.53Single4MBSMaraviroc4MBS-CCR5-Maraviroc
23.53Single4ZJCSB-6740424ZJC-OX1-SB-674042
23.53Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
23.53Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
23.53Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
23.53Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
23.53Single6TP3Nemorexant6TP3-OX1-Nemorexant
23.53Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
23.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.53Single6ZG9GSK10347026ZG9-M1-GSK1034702
23.53Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
23.53Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
23.53Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
23.53Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
23.53Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
23.53Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
23.53Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
23.53Single7UL3Famotidine7UL3-H2-Famotidine
23.53Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.53Single7VODCariprazine7VOD-5-HT2A-Cariprazine
23.53Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
23.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
23.53Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
23.53Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
23.53Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
23.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
23.53Single8IHKAcifran8IHK-HCA3-Acifran
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
23.53Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
23.53Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
23.53Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
23.53Single8K5CAcipimox8K5C-HCA2-Acipimox
23.53Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
23.53Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
23.53Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
23.53Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
23.53Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
23.53Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
23.53Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
23.53Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
23.53Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
23.53Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
23.53Consensusgrh_offOrthosteric Ligandgnrh1_off
23.53Consensushca_onOrthosteric Ligandhca2_on
23.53Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
23.53Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
23.08Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
23.08Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
23.08Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
23.08Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
23.08Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
23.08Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
23.08Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.08Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.08Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
22.73Single5EE7MK08935EE7-Glucagon-MK0893
22.73Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
22.73Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
22.73Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
22.73Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7SK9CCX6627SK9-ACKR3-CCX662
22.73Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
22.73Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
22.73Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
22.73Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
22.73Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
22.73Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
22.73Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
22.73Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
22.73Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
22.22Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
22.22Single4QIMANTA XV4QIM-SMO-ANTA XV
22.22Single4XT3Fractalkine4XT3-US28-Fractalkine
22.22Single5DHGC-355DHG-NOP-C-35
22.22Single5DSGTiotropium5DSG-M4-Tiotropium
22.22Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
22.22Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.22Single6DRXLisuride6DRX-5-HT2B-Lisuride
22.22Single6IIVDaltroban6IIV-TP-Daltroban
22.22Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
22.22Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
22.22Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
22.22Single7F83PF-051904577F83-Ghrelin-PF-05190457
22.22Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
22.22Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.22Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
22.22Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
22.22Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
22.22Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
22.22Single7V3ZCP559407V3Z-CB1-CP55940
22.22Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
22.22Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.22Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
22.22Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.22Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
22.22Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
22.22Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8K5DGSK2560738K5D-HCA2-GSK256073
22.22Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
22.22Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
22.22Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
22.22Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
22.22Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
22.22Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.22Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.22Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
22.22Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
22.22Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
22.22Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
22.22Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca_on_gpOrthosteric Ligandhca2_on_gp
22.22Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
22.22Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
22.22Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
22.22Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
22.22Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
21.74Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
21.74Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
21.74Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
21.74Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
21.74Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
21.74Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
21.74Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
21.74Single8IEBA1LYA8IEB-GPR156-A1LYA
21.74Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
21.74Single8KIGSHU91198KIG-MC3-SHU9119-Ca
21.74Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
21.74Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
21.74Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
21.74Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.74Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
21.74Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.74Consensuslpl_onOrthosteric Ligands1p_on lpa_on
21.74Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
21.74Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
21.74Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
21.74Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
21.43Single3OE8IT1t3OE8-CXCR4-IT1t
21.43Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
21.43Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
21.43Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
21.43Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
21.43Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
21.43Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
21.43Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
21.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
21.05Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
21.05Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
21.05Single5CGCHTL142425CGC-mGlu5-HTL14242
21.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.05Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
21.05Single6TP6Filorexant6TP6-OX1-Filorexant
21.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
21.05Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
21.05Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
21.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
21.05Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
21.05Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
21.05Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
21.05Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
21.05Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
21.05Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
21.05Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
21.05Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
21.05Consensusblt_offOrthosteric Ligandblt1_off
21.05Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.05Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.05Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
21.05Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.05Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.05Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
20.83Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
20.83Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.83Single7SK5CXCL127SK5-ACKR3-CXCL12
20.83Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
20.83Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
20.83Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
20.83Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
20.83Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
20.83Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
20.83Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
20.83Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
20.83Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
20.69Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.59Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.59Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
20.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
20.00Single4DJHJDTic4DJH-κ-JDTic
20.00Single5TZRMK86665TZR-FFA1-MK8666
20.00Single5V56TC1145V56-SMO-TC114
20.00Single5XR8AM8415XR8-CB1-AM841
20.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
20.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
20.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
20.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
20.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
20.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
20.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
20.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
20.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
20.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
20.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
20.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
20.00Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
20.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
20.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
20.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
20.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
20.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
20.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
20.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
20.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
20.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
20.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
20.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
20.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
20.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
20.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
20.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
20.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
20.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
20.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
20.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
20.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
20.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
20.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
20.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
19.35Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
19.23Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
19.23Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
19.23Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
19.23Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
19.23Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
19.23Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
19.23Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.23Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.23Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
19.05Single4N4WSANT-14N4W-SMO-SANT-1
19.05Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
19.05Single4XEENeurotensin4XEE-NTS1-Neurotensin
19.05Single4XESNeurotensin4XES-NTS1-Neurotensin
19.05Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
19.05Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
19.05Single6IIURamatroban6IIU-TP-Ramatroban
19.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
19.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.05Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
19.05Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
19.05Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
19.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
19.05Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
19.05Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.05Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
19.05Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
19.05Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
19.05Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.05Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
19.05Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
19.05Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.75Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
18.75Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
18.75Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
18.75Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
18.75Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
18.75Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
18.75Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
18.75Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
18.75Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
18.75Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
18.75Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
18.75Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
18.75Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
18.75Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.75Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
18.75Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
18.75Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
18.75Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
18.75Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
18.75Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
18.75Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
18.75Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
18.75Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
18.75Consensusgq_nucleotideOrthosteric Ligandgq_p2y
18.75Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.75Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
18.75Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.52Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
18.52Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
18.52Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
18.52Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
18.52Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
18.52Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
18.52Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
18.52Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
18.52Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
18.18Single4BUONeurotensin4BUO-NTS1-Neurotensin
18.18Single5CGDHTL142425CGD-mGlu5-HTL14242
18.18Single6K1QIRL25006K1Q-ETB-IRL2500
18.18Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
18.18Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
18.18Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
18.18Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
18.18Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
18.18Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
18.18Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
18.18Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
18.18Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
18.18Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8XVJMacitentan8XVJ-ETA-Macitentan
18.18Single8XVUCXCL28XVU-CXCR2-CXCL2
18.18Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
18.18Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
18.18Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
18.18Consensuschemerin_onOrthosteric Ligandcml1_on
18.18Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
18.18Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
18.18Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single6FJ3PTH6FJ3-PTH1-PTH
17.86Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.86Single7SK3CXCL127SK3-ACKR3-CXCL12
17.86Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
17.86Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
17.65Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
17.65Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
17.65Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
17.65Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
17.65Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
17.65Single5U09Taranabant5U09-CB1-Taranabant
17.65Single6AKYMaraviroc6AKY-CCR5-Maraviroc
17.65Single6B73MP11046B73-κ-MP1104
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single7F8YDevazepide7F8Y-CCKA-Devazepide
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
17.65Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
17.65Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
17.65Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
17.65Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
17.65Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
17.65Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
17.65Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
17.65Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
17.65Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
17.65Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
17.65Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
17.65Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
17.65Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
17.65Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Single9BA0A1AKN9BA0-CB1-A1AKN
17.65Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
17.65Consensusangiotensin_offOrthosteric Ligandat1_off
17.65Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
17.65Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.65Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
17.65Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.39Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
17.39Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.39Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
17.39Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.39Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
17.39Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
17.39Single8IEIA1LYA8IEI-GPR156-A1LYA
17.39Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
17.39Single8XQJJN2418XQJ-Apelin-JN241
17.39Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
17.24Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
17.24Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
17.24Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
17.24Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
17.24Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
16.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.67Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.67Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
16.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.67Single6VI4JDTic6VI4-κ-JDTic
16.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
16.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
16.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
16.67Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
16.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
16.67Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
16.67Single7VV6C48/807VV6-MRGPRX2-C48/80
16.67Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
16.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
16.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
16.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.67Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
16.67Single8XWNCXCL88XWN-CXCR2-CXCL8
16.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
16.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.67Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
16.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
16.67Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
16.67Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
16.67Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
16.13Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
16.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
16.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
16.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.00Single7XNACYN1548067XNA-SST2-CYN154806
16.00Single8IEBA1LYA8IEB-GPR156-A1LYA
16.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
16.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
15.79Single4YAYZD-71554YAY-AT1-ZD-7155
15.79Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
15.79Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
15.79Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.79Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
15.79Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
15.79Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.79Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.79Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.79Single9IYAONO-97105319IYA-GPR55-ONO-9710531
15.79Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.79Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.79Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
15.62Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
15.62Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
15.62Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.38Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
15.38Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
15.38Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
15.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
15.38Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
15.38Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
15.38Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.38Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.15Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.15Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
15.00Single4JKVTaladegib4JKV-SMO-Taladegib
15.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
15.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
15.00Single6Z4SSR486926Z4S-NTS1-SR48692
15.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
15.00Single7C4SS1P7C4S-S1P3-S1P
15.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
15.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
15.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
15.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
15.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
15.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
15.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.00Consensusep_offOrthosteric Ligandep4_off
15.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
14.81Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.81Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
14.81Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.81Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
14.71Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.71Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.71Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
14.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
14.29Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
14.29Single4BV0Neurotensin4BV0-NTS1-Neurotensin
14.29Single5V57TC1145V57-SMO-TC114
14.29Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single6OS1TRV0266OS1-AT1-TRV026
14.29Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
14.29Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
14.29Single7F1TMIP-1a7F1T-CCR5-MIP-1a
14.29Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
14.29Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
14.29Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
14.29Single7P2L4YI7P2L-mGlu5-4YI
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
14.29Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.29Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
14.29Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.29Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
14.29Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
14.29Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
14.29Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
14.29Single9BJKNAM9BJK-μ-Naloxone-NAM
14.29Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
14.29Consensusneurotensin_onOrthosteric Ligandnts1_on
14.29Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
14.29Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.79Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
13.79Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
13.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.79Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
13.79Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
13.79Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.79Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
13.79Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
13.64Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.64Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
13.64Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.64Single5X33BIIL2605X33-BLT1-BIIL260
13.64Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
13.64Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single6YVRNTS8-136YVR-NTS1-NTS8-13
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
13.64Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.64Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
13.64Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
13.64Single8XQJJN2418XQJ-Apelin-JN241
13.64Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.64Single8XWACXCL18XWA-CXCR2-CXCL1
13.64Single8XWMCXCL68XWM-CXCR2-CXCL6
13.64Single8XWSCXCL58XWS-CXCR2-CXCL5
13.64Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
13.64Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.64Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
13.64Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.64Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.51Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
13.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
13.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.33Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
13.33Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
13.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
13.33Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
13.33Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
13.33Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
13.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.33Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
13.33Consensusp2y_offOrthosteric Ligandp2y1_off
13.16Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.04Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
13.04Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single8XWFCXCL38XWF-CXCR2-CXCL3
13.04Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
13.04Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
12.90Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
12.90Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.90Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
12.90Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.90Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.90Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.90Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
12.90Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.82Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.50Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
12.50Single4XNWMRS25004XNW-P2Y1-MRS2500
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6KNMJN241-96KNM-Apelin-JN241-9
12.50Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.50Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.50Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
12.50Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.50Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
12.50Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.50Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
12.50Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
12.50Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
12.50Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.50Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.12Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
12.12Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
12.00Single7QA8Peptide7QA8-STE2-Peptide
12.00Single7QA8Peptide7QA8-STE2-Peptide
12.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Single8IEIA1LYA8IEI-GPR156-A1LYA
12.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
12.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Consensussomatostatin_offOrthosteric Ligandsst2_off
11.76Single5L7IVismodegib5L7I-SMO-Vismodegib
11.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.76Single6LI0C176LI0-GPR52-C17
11.76Single7UL2SR486927UL2-NTS1-SR48692-Na
11.76Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
11.76Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
11.76Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.76Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
11.76Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.76Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
11.76Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Consensusneurotensin_offOrthosteric Ligandnts1_off
11.76Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.54Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
11.54Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.43Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.43Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
11.43Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.11Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.71Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.71Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.71Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
10.71Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.53Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.53Single6ZINSR486926ZIN-NTS1-SR48692
10.53Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
10.53Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8K2WAMG4878K2W-CXCR3-AMG487
10.53Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
10.53Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.53Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.00Single6FFHFenobam6FFH-mGlu5-Fenobam
10.00Single6GPSMK08126GPS-CCR2-MK0812
10.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
10.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
10.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
10.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
10.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
10.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
10.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt_onOrthosteric Ligandblt1_on
10.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
10.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
10.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusleukotriene_onOrthosteric Ligandblt_on
10.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
10.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.68Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.52Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
9.52Single6GPXMK08126GPX-CCR2-MK0812
9.52Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.52Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.52Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.38Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
9.09Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
9.09Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
9.09Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
9.09Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.33Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
8.33Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
8.00Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.69Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.69Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
7.14Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
6.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.25Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.25Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.25Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
6.25Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.88Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.88Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.88Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.56Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.56Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.56Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.26Single4QINSAG1.54QIN-SMO-SAG1.5
5.26Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.26Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.26Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.26Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
5.26Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.26Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
5.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
5.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.76Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.76Single5T04Neurotensin5T04-NTS1-Neurotensin
4.76Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.76Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.76Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.76Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.55Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.35Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17Single8GTMBMK-C2038GTM-CRF1-BMK-C203

PDB Summary
PDB 8CU6
Class A
SubFamily Nucleotide
Type Adenosine
SubType A2A
Species Homo Sapiens
Ligand LJ-4517
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.8
Date 2022-08-31
D.O.I. 10.1021/acs.jmedchem.2c00462
Net Summary
Imin 3
Number of Linked Nodes 273
Number of Links 327
Number of Hubs 50
Number of Links mediated by Hubs 180
Number of Communities 10
Number of Nodes involved in Communities 85
Number of Links involved in Communities 119
Path Summary
Number Of Nodes in MetaPath 54
Number Of Links MetaPath 53
Number of Shortest Paths 52365
Length Of Smallest Path 3
Average Path Length 13.4551
Length of Longest Path 31
Minimum Path Strength 1.505
Average Path Strength 6.48609
Maximum Path Strength 26.805
Minimum Path Correlation 0.7
Average Path Correlation 0.92525
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 49.8346
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.3369
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled adenosine receptor activity   • protein-containing complex binding   • protein binding   • calmodulin binding   • identical protein binding   • cytoskeletal protein binding   • alpha-actinin binding   • actinin binding   • lipid binding   • type 5 metabotropic glutamate receptor binding   • signaling receptor binding   • glutamate receptor binding   • G protein-coupled receptor binding   • G protein-coupled glutamate receptor binding   • enzyme binding   • electron transport chain   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • response to stimulus   • response to chemical   • response to xenobiotic stimulus   • multicellular organismal process   • regulation of body fluid levels   • wound healing   • hemostasis   • biological regulation   • blood coagulation   • response to stress
Gene OntologyBiological Process• electron transport chain   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • response to stimulus   • response to chemical   • response to xenobiotic stimulus   • multicellular organismal process   • regulation of body fluid levels   • wound healing   • hemostasis   • biological regulation   • blood coagulation   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • regulation of cellular process   • regulation of alpha-beta T cell activation   • regulation of leukocyte activation   • negative regulation of biological process   • regulation of cell activation   • lymphocyte activation   • negative regulation of lymphocyte activation   • leukocyte cell-cell adhesion   • negative regulation of cell adhesion   • leukocyte activation   • cell adhesion   • cell-cell adhesion   • T cell activation   • negative regulation of cellular process   • alpha-beta T cell activation   • regulation of immune system process   • regulation of multicellular organismal process   • regulation of cell-cell adhesion   • regulation of biological process   • regulation of cell adhesion   • cell activation   • regulation of T cell activation   • negative regulation of cell activation   • negative regulation of T cell activation   • negative regulation of immune system process   • negative regulation of leukocyte cell-cell adhesion   • immune system process   • negative regulation of cell-cell adhesion   • regulation of leukocyte cell-cell adhesion   • negative regulation of alpha-beta T cell activation   • negative regulation of multicellular organismal process   • negative regulation of leukocyte activation   • regulation of lymphocyte activation   • developmental process   • multicellular organism development   • central nervous system development   • anatomical structure development   • nervous system development   • system development   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • cellular response to stimulus   • positive regulation of cell communication   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • regulation of programmed cell death   • positive regulation of apoptotic signaling pathway   • positive regulation of response to stimulus   • signal transduction   • positive regulation of cellular process   • positive regulation of programmed cell death   • regulation of apoptotic process   • cell death   • positive regulation of apoptotic process   • apoptotic signaling pathway   • regulation of response to stimulus   • apoptotic process   • programmed cell death   • positive regulation of signaling   • regulation of apoptotic signaling pathway   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • import into cell   • phagocytosis   • endocytosis   • vesicle-mediated transport   • response to nitrogen compound   • response to purine-containing compound   • response to caffeine   • response to alkaloid   • purinergic nucleotide receptor signaling pathway   • cell surface receptor signaling pathway   • G protein-coupled purinergic receptor signaling pathway   • G protein-coupled receptor signaling pathway   • G protein-coupled adenosine receptor signaling pathway   • system process   • sensory perception   • nervous system process   • negative regulation of vascular permeability   • regulation of vascular permeability   • circulatory system process   • vascular process in circulatory system   • blood circulation   • startle response   • regulation of response to external stimulus   • neuromuscular process   • negative regulation of response to stimulus   • prepulse inhibition   • response to external stimulus   • negative regulation of response to external stimulus   • nitrogen compound transport   • positive regulation of neurotransmitter secretion   • positive regulation of amine transport   • acetylcholine secretion, neurotransmission   • establishment of localization in cell   • positive regulation of acetylcholine secretion, neurotransmission   • positive regulation of neurotransmitter transport   • positive regulation of synaptic transmission, cholinergic   • neurotransmitter secretion   • positive regulation of synaptic transmission   • regulation of acetylcholine secretion, neurotransmission   • neurotransmitter transport   • organic cation transport   • acetate ester transport   • regulation of secretion   • signal release from synapse   • acetylcholine transport   • cellular localization   • positive regulation of secretion by cell   • regulation of secretion by cell   • secretion by cell   • positive regulation of secretion   • signal release   • acetylcholine secretion   • secretion   • regulation of neurotransmitter transport   • export from cell   • amine transport   • positive regulation of transport   • regulation of neurotransmitter secretion   • synaptic transmission, cholinergic   • regulation of amine transport   • regulation of synaptic transmission, cholinergic   • RNA metabolic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • primary metabolic process   • regulation of macromolecule metabolic process   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • regulation of gene expression   • biosynthetic process   • regulation of macromolecule biosynthetic process   • regulation of DNA-templated transcription   • macromolecule metabolic process   • regulation of metabolic process   • cellular developmental process   • astrocyte differentiation   • cell development   • astrocyte activation   • glial cell development   • neurogenesis   • astrocyte development   • gliogenesis   • cell differentiation   • defense response   • glial cell differentiation   • glial cell activation   • inflammatory response   • neuroinflammatory response   • synaptic transmission, dopaminergic   • phospholipase C-activating G protein-coupled receptor signaling pathway   • regulation of postsynaptic membrane potential   • chemical synaptic transmission, postsynaptic   • inhibitory postsynaptic potential   • regulation of membrane potential   • cellular defense response   • behavior   • locomotory behavior   • intracellular signal transduction   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • long-term synaptic potentiation   • positive regulation of long-term synaptic potentiation   • regulation of synaptic plasticity   • regulation of long-term synaptic potentiation   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • positive regulation of synaptic transmission, glutamatergic   • regulation of mitochondrial membrane potential   • positive regulation of synaptic transmission, GABAergic   • synaptic transmission, GABAergic   • regulation of synaptic transmission, GABAergic   • regulation of defense response   • negative regulation of inflammatory response   • regulation of inflammatory response   • regulation of response to stress   • negative regulation of defense response   • renal system process   • positive regulation of urine volume   • regulation of urine volume   • eating behavior   • feeding behavior   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • rhythmic process   • circadian sleep/wake cycle, sleep   • circadian sleep/wake cycle   • rhythmic behavior   • regulation of circadian sleep/wake cycle   • circadian rhythm   • regulation of circadian rhythm   • regulation of behavior   • circadian behavior   • positive regulation of behavior   • positive regulation of circadian rhythm   • positive regulation of multicellular organismal process   • sleep   • positive regulation of circadian sleep/wake cycle, sleep   • regulation of circadian sleep/wake cycle, sleep   • circadian sleep/wake cycle process   • monoamine transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • catecholamine transport   • norepinephrine transport   • catecholamine secretion   • norepinephrine secretion   • regulation of norepinephrine secretion   • neuron apoptotic process   • negative regulation of neuron apoptotic process   • negative regulation of programmed cell death   • negative regulation of apoptotic process   • regulation of neuron apoptotic process   • cell projection organization   • plasma membrane bounded cell projection morphogenesis   • neuron projection development   • cell morphogenesis   • cellular component organization   • cell projection morphogenesis   • neuron differentiation   • neuron projection morphogenesis   • cellular component organization or biogenesis   • plasma membrane bounded cell projection organization   • generation of neurons   • anatomical structure morphogenesis   • neuron development   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of tube diameter   • regulation of tube size   • blood vessel diameter maintenance   • vasodilation   • regulation of anatomical structure size   • excitatory postsynaptic potential   • protein localization   • establishment of protein localization   • regulation of protein localization   • positive regulation of establishment of protein localization   • protein localization to extracellular region   • positive regulation of protein transport   • cellular macromolecule localization   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • regulation of protein transport   • protein secretion   • positive regulation of protein secretion   • regulation of protein secretion   • protein transport   • regulation of cellular localization   • macromolecule localization   • positive regulation of protein localization   • negative regulation of cell population proliferation   • cell population proliferation   • regulation of cell population proliferation   • response to amine   • response to amphetamine   • membrane depolarization   • regulation of glutamate secretion   • regulation of amino acid transport   • glutamate secretion   • organic anion transport   • carboxylic acid transport   • positive regulation of glutamate secretion   • positive regulation of organic acid transport   • organic acid transport   • amino acid transport   • acidic amino acid transport   • positive regulation of amino acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • cellular anatomical structure   • periplasmic space   • cell periphery   • postsynapse   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • presynapse   • presynaptic active zone   • presynaptic membrane
Gene OntologyCellular Component• cellular anatomical structure   • periplasmic space   • cell periphery   • postsynapse   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • presynapse   • presynaptic active zone   • presynaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • glutamatergic synapse   • axon   • cell leading edge   • axolemma   • leading edge membrane   • neuron projection membrane   • main axon   • cell projection membrane   • cell body   • neuronal cell body   • polymeric cytoskeletal fiber   • intracellular anatomical structure   • intracellular membraneless organelle   • intermediate filament cytoskeleton   • intracellular organelle   • cytoskeleton   • organelle   • membraneless organelle   • intermediate filament   • supramolecular fiber   • supramolecular polymer   • supramolecular complex   • neuron to neuron synapse   • asymmetric synapse
SCOP2Domain Identifier• Cytochromes   • G protein-coupled receptor-like
SCOP2Family Identifier• Cytochromes   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeLJX
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeLJX
Name(2R,3R,4R)-2-[(8P)-6-amino-2-(hex-1-yn-1-yl)-8-(thiophen-2-yl)-9H-purin-9-yl]oxolane-3,4-diol
Synonyms
Identifier
FormulaC19 H21 N5 O3 S
Molecular Weight399.467
SMILES
PubChem164885960
Formal Charge0
Total Atoms49
Total Chiral Atoms3
Total Bonds52
Total Aromatic Bonds15

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP29274
Sequence
>8CU6_Chain_R
PIMGSSVYI TVELAIAVL AILGNVLVC WAVWLNSNL QNVTNYFVV 
SLAAADILV GVLAIPFAI TISTGFCAA CHGCLFIAC FVLVLAQSS 
IFSLLAIAI DRYIAIAIP LRYNGLVTG TRAAGIIAI CWVLSFAIG 
LTPMLGWNN CGQPKEGKA HSQGCGEGQ VACLFEDVV PMNYMVYFN 
FFACVLVPL LLMLGVYLR IFAAARRQL ERARSTLQK EVHAAKSAA 
IIAGLFALC WLPLHIINC FTFFCPDCS HAPLWLMYL AIVLSHTNS 
VVNPFIYAY RIREFRQTF RKIIRSHVL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
a2a_off3RFM-A2A-Caffeine
8C9W-A2A-Etrumadenant
3UZA-A2A-GTPL9236
8GNG-A2A-Istradefylline
8CU6-A2A-LJ-4517
7PX4-A2A-PSB-2113
7PYR-A2A-PSB-2115
8DU3-A2A-PubChem 105526064
8JWY-A2A-2-118
8PWN-A2A-Theophylline
5IU4-A2A-ZM-241385-Na
5OLZ-A2A-PubChem 135566609-Na
6GT3-A2A-Imaradenant-Na
5OLV-A2A-LUAA41063-Na
5N2R-A2A-PSB-36-Na
5IU7-A2A-Q27456346-Na
5OLH-A2A-Vipadenant-Na
5OLO-A2A-Tozadenant-Na
6ZDR-A2A-HMS1413f12-Na
8GNE-A2A-KW-6356-Na
8JWZ-A2A-AB928-Na
5IU8-A2A-Q27456347-Na
5IUB-A2A-Q27456344-Na
6ZDV-A2A-Chromone 5d-Na
5IUA-A2A-Q27456348-Na
8A2P-A2A-LUAA47070-Na

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9FUPANucleotideAdenosineA2AHomo sapiensIstradefyllineNa-2.52025-01-22doi.org/10.1038/s42004-024-01404-y
8RWXANucleotideAdenosineA2AHomo sapiensStilSwitch3Na-3.052025-01-08doi.org/10.1038/s41467-024-55109-w
8RWIANucleotideAdenosineA2AHomo sapiensStilSwitch2Na-2.82025-01-08doi.org/10.1038/s41467-024-55109-w
8RWHANucleotideAdenosineA2AHomo sapiensStilSwitch2Na-2.452025-01-08doi.org/10.1038/s41467-024-55109-w
8RWEANucleotideAdenosineA2AHomo sapiensStilSwitch4Na-2.22025-01-08doi.org/10.1038/s41467-024-55109-w
8RWDANucleotideAdenosineA2AHomo sapiensStilSwitch3Na-2.052025-01-08doi.org/10.1038/s41467-024-55109-w
8RWCANucleotideAdenosineA2AHomo sapiensStilSwitch2Na-2.312025-01-08doi.org/10.1038/s41467-024-55109-w
8RW7ANucleotideAdenosineA2AHomo sapiensStilSwitch1Na-2.252025-01-08doi.org/10.1038/s41467-024-55109-w
8RW4ANucleotideAdenosineA2AHomo sapiensAzoSwitch2Na-2.22025-01-08doi.org/10.1038/s41467-024-55109-w
8RW0ANucleotideAdenosineA2AHomo sapiensIstradefyllineNa-1.942025-01-0810.1038/s41467-024-55109-w
8RVWANucleotideAdenosineA2AHomo sapiensStilSwitch3Na-2.652025-01-08doi.org/10.1038/s41467-024-55109-w
8UGWANucleotideAdenosineA2AHomo sapiensPubChem 3086599--3.92024-12-18doi.org/10.1038/s41557-024-01719-2
8RLNANucleotideAdenosineA2AHomo sapiensLUF5834--2.432024-06-19doi.org/10.1021/acsptsci.4c00051
8RQQANucleotideAdenosineA2AHomo sapiensZM-241385Na-2.372024-04-03doi.org/10.1021/acs.cgd.4c00087
8WDTANucleotideAdenosineA2AHomo sapiensphotoNECA--3.342024-01-17doi.org/10.1016/j.bbrc.2023.149393
8A2PANucleotideAdenosineA2AHomo sapiensLUAA47070Na-3.52023-08-3010.1107/S1600576723006428
8A2OANucleotideAdenosineA2AHomo sapiensTheophyllineNa-3.452023-08-3010.1107/S1600576723006428
8JWZANucleotideAdenosineA2AHomo sapiensAB928Na-2.372023-08-1610.1007/s11427-023-2459-8
8JWYANucleotideAdenosineA2AHomo sapiens2-118--2.332023-08-1610.1007/s11427-023-2459-8
8C9WANucleotideAdenosineA2AHomo sapiensEtrumadenant--2.112023-07-1210.1038/s42004-023-00894-6
8CICANucleotideAdenosineA2AHomo sapiensEtrumadenantNa-2.12023-05-3110.1038/s42004-023-00894-6
8GNGANucleotideAdenosineA2AHomo sapiensIstradefylline--3.22023-03-2210.1124/molpharm.122.000633
8GNEANucleotideAdenosineA2AHomo sapiensKW-6356Na-2.32023-03-2210.1124/molpharm.122.000633
8FYNANucleotideAdenosineA2AHomo sapiensZM-241385Na-22023-03-0810.1038/s41467-023-36733-4
8PWNANucleotideAdenosineA2AHomo sapiensTheophylline--2.752023-10-2510.1038/s42004-023-01014-0
8CU7ANucleotideAdenosineA2AHomo sapiensLJ-4517Na-2.052022-08-3110.1021/acs.jmedchem.2c00462
8DU3ANucleotideAdenosineA2AHomo sapiensPubChem 105526064--2.52022-08-1010.1016/j.ejmech.2022.114620
7T32ANucleotideAdenosineA2AHomo sapiensZM-241385--3.42022-08-1010.1038/s41467-022-32125-2
7EZCANucleotideAdenosineA2AHomo sapiensUKA--3.82022-04-1310.1107/S2052252522001907
7PYRANucleotideAdenosineA2AHomo sapiensPSB-2115--2.62022-03-0210.1002/anie.202115545
7PX4ANucleotideAdenosineA2AHomo sapiensPSB-2113--2.252022-03-0210.1002/anie.202115545
7RM5ANucleotideAdenosineA2AHomo sapiensZM-241385Na-2.792021-09-0810.1073/pnas.2106041118
7AROANucleotideAdenosineA2AHomo sapiensLUF5833Na-3.122021-04-0710.1021/acs.jmedchem.0c01856
6LPLANucleotideAdenosineA2AHomo sapiensZM-241385Na-22020-11-2510.1038/s41598-020-76277-x
6LPKANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPJANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6WQAANucleotideAdenosineA2AHomo sapiensZM-241385Na-22020-11-1810.1107/S2052252520012701
6ZDVANucleotideAdenosineA2AHomo sapiensChromone 5dNa-2.132020-09-1610.1002/anie.202003788
6ZDRANucleotideAdenosineA2AHomo sapiensHMS1413f12Na-1.922020-09-1610.1002/anie.202003788
6S0QANucleotideAdenosineA2AHomo sapiensZM-241385--2.652020-07-1510.1107/S2052252520011379
6S0LANucleotideAdenosineA2AHomo sapiensZM-241385--2.652020-07-1510.1107/S2052252520011379
6PS7ANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.852019-11-1310.1107/S2052252519013137
6JZHANucleotideAdenosineA2AHomo sapiensZM-241385Na-2.252019-10-3010.1107/S1600576719012846
6GT3ANucleotideAdenosineA2AHomo sapiensImaradenantNa-22019-06-2610.1136/jitc-2019-000417
6MH8ANucleotideAdenosineA2AHomo sapiensZM-241385--4.22019-04-2410.1107/S205225251900263X
6GDGANucleotideAdenosineA2AHomo sapiensNECA-Gs/β1/γ14.112018-05-1610.7554/eLife.35946
6GDG (No Gprot) ANucleotideAdenosineA2AHomo sapiensNECA-4.112018-05-1610.7554/eLife.35946
5WF6ANucleotideAdenosineA2AHomo sapiensUK-432097--2.92018-02-2110.1016/j.str.2017.12.013
5WF5ANucleotideAdenosineA2AHomo sapiensUK-432097--2.62018-02-2110.1016/j.str.2017.12.013
5OM4ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-22018-01-1710.1038/s41598-017-18570-w
5OM1ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-2.12018-01-1710.1038/s41598-017-18570-w
5OLZANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-1.92018-01-1710.1038/s41598-017-18570-w
5OLVANucleotideAdenosineA2AHomo sapiensLUAA41063Na-22018-01-1710.1038/s41598-017-18570-w
5OLOANucleotideAdenosineA2AHomo sapiensTozadenantNa-3.12018-01-1710.1038/s41598-017-18570-w
5OLHANucleotideAdenosineA2AHomo sapiensVipadenantNa-2.62018-01-1710.1038/s41598-017-18570-w
5OLGANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.872018-01-1710.1038/s41598-017-18570-w
6AQFANucleotideAdenosineA2AHomo sapiensZM-241385--2.512018-01-1010.1016/j.cell.2017.12.004
5VRAANucleotideAdenosineA2AHomo sapiensZM-241385Na-2.352017-12-1310.1038/nprot.2017.135
5NM4ANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.72017-09-2710.1038/s41467-017-00630-4
5NM2ANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.952017-09-2710.1038/s41467-017-00630-4
5NLXANucleotideAdenosineA2AHomo sapiensZM-241385Na-2.142017-09-2710.1038/s41467-017-00630-4
5N2RANucleotideAdenosineA2AHomo sapiensPSB-36Na-2.82017-07-2610.1016/j.str.2017.06.012
5MZPANucleotideAdenosineA2AHomo sapiensCaffeineNa-2.12017-07-2610.1016/j.str.2017.06.012
5MZJANucleotideAdenosineA2AHomo sapiensTheophyllineNa-22017-07-2610.1016/j.str.2017.06.012
5JTBANucleotideAdenosineA2AHomo sapiensZM-241385--2.82017-05-3110.1126/sciadv.1602952
5UVIANucleotideAdenosineA2AHomo sapiensZM-241385--3.22017-05-2410.1107/S205225251700570X
5UIGANucleotideAdenosineA2AHomo sapiensCmpd-1--3.52017-02-0810.1073/pnas.1621423114
5K2DANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.92016-09-2110.1126/sciadv.1600292
5K2CANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.92016-09-2110.1126/sciadv.1600292
5K2BANucleotideAdenosineA2AHomo sapiensZM-241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2AANucleotideAdenosineA2AHomo sapiensZM-241385Na-2.52016-09-2110.1126/sciadv.1600292
5G53ANucleotideAdenosineA2AHomo sapiensNECA-Gs3.42016-08-0310.1038/nature18966
5G53 (No Gprot) ANucleotideAdenosineA2AHomo sapiensNECA-3.42016-08-0310.1038/nature18966
5IUBANucleotideAdenosineA2AHomo sapiensQ27456344Na-2.12016-06-2910.1021/acs.jmedchem.6b00653
5IUAANucleotideAdenosineA2AHomo sapiensQ27456348Na-2.22016-06-2910.1021/acs.jmedchem.6b00653
5IU8ANucleotideAdenosineA2AHomo sapiensQ27456347Na-22016-06-2910.1021/acs.jmedchem.6b00653
5IU7ANucleotideAdenosineA2AHomo sapiensQ27456346Na-1.92016-06-2910.1021/acs.jmedchem.6b00653
5IU4ANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.722016-06-2910.1021/acs.jmedchem.6b00653
4UHRANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
4UG2ANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
4EIYANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.82012-07-2510.1126/science.1219218
3UZCANucleotideAdenosineA2AHomo sapiens4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol--3.342012-03-2110.1021/jm201376w
3UZAANucleotideAdenosineA2AHomo sapiensGTPL9236--3.272012-03-2110.1021/jm201376w
3VGAANucleotideAdenosineA2AHomo sapiensZM-241385Antibody-3.12012-02-0110.1038/nature10750
3VG9ANucleotideAdenosineA2AHomo sapiensZM-241385Antibody-2.72012-02-0110.1038/nature10750
3RFMANucleotideAdenosineA2AHomo sapiensCaffeine--3.62011-09-0710.1016/j.str.2011.06.014
3REYANucleotideAdenosineA2AHomo sapiensXAC--3.312011-09-0710.1016/j.str.2011.06.014
3PWHANucleotideAdenosineA2AHomo sapiensZM-241385--3.32011-09-0710.1016/j.str.2011.06.014
2YDVANucleotideAdenosineA2AHomo sapiensNECA--2.62011-05-1810.1038/nature10136
2YDOANucleotideAdenosineA2AHomo sapiensAdenosine--32011-05-1810.1038/nature10136
3QAKANucleotideAdenosineA2AHomo sapiensUK-432097--2.712011-03-0910.1126/science.1202793
3EMLANucleotideAdenosineA2AHomo sapiensZM-241385--2.62008-10-1410.1126/science.1164772




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