psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T88	3.89	Yes	No	1	0	6
2	L:L:?1	R:R:F168	12.06	Yes	Yes	0	0	4
3	L:L:?1	R:R:W246	6.02	Yes	Yes	1	0	8
4	L:L:?1	R:R:L249	24.67	Yes	No	1	0	5
5	L:L:?1	R:R:N253	7.25	Yes	No	1	0	5
6	L:L:?1	R:R:M270	3.73	Yes	No	0	0	4
7	L:L:?1	R:R:I274	11.31	Yes	Yes	1	0	4
8	L:L:?1	R:R:S277	2.97	Yes	No	0	0	7
9	R:R:E13	R:R:Y9	15.71	Yes	Yes	1	6	5
10	R:R:S67	R:R:Y9	5.09	No	Yes	1	3	5
11	R:R:Y271	R:R:Y9	22.84	No	Yes	1	3	5
12	R:R:I274	R:R:Y9	6.04	Yes	Yes	1	4	5
13	R:R:I10	R:R:L14	5.71	No	No	0	6	5
14	R:R:I10	R:R:I64	7.36	No	No	0	6	6
15	R:R:I16	R:R:V12	3.07	No	No	0	7	5
16	R:R:V12	R:R:V275	3.21	No	No	0	5	5
17	R:R:E13	R:R:I274	4.1	Yes	Yes	1	6	4
18	R:R:E13	R:R:V275	4.28	Yes	No	0	6	5
19	R:R:E13	R:R:H278	16	Yes	Yes	1	6	6
20	R:R:I16	R:R:V282	4.61	No	No	0	7	7
21	R:R:A17	R:R:I60	4.87	No	Yes	0	6	6
22	R:R:L19	R:R:V282	2.98	No	No	0	5	7
23	R:R:I21	R:R:V57	6.14	No	No	0	6	5
24	R:R:N24	R:R:V27	4.43	Yes	No	0	9	9
25	R:R:A49	R:R:N24	3.13	No	Yes	0	9	9
26	R:R:D52	R:R:N24	14.81	Yes	Yes	2	9	9
27	R:R:I53	R:R:N24	9.91	No	Yes	0	7	9
28	R:R:N24	R:R:P285	6.52	Yes	No	2	9	9
29	R:R:F295	R:R:L26	4.87	Yes	No	0	8	6
30	R:R:L33	R:R:W29	6.83	No	No	0	5	4
31	R:R:I302	R:R:W29	7.05	No	No	0	6	4
32	R:R:A30	R:R:F295	4.16	No	Yes	0	8	8
33	R:R:Q38	R:R:V31	4.3	No	No	0	7	7
34	R:R:V31	R:R:V46	4.81	No	No	0	7	5
35	R:R:N34	R:R:N36	4.09	No	No	0	6	5
36	R:R:L37	R:R:N34	9.61	No	No	0	8	6
37	R:R:L37	R:R:T298	4.42	No	No	0	8	7
38	R:R:N39	R:R:V40	7.39	No	No	0	7	6
39	R:R:V116	R:R:V40	4.81	No	No	0	7	6
40	R:R:N42	R:R:T41	7.31	No	No	0	8	8
41	R:R:D101	R:R:T41	2.89	No	No	0	9	8
42	R:R:D101	R:R:F44	10.75	No	Yes	0	9	7
43	R:R:F44	R:R:I124	3.77	Yes	No	0	7	5
44	R:R:F44	R:R:I125	3.77	Yes	No	0	7	8
45	R:R:I125	R:R:S47	9.29	No	No	0	8	9
46	R:R:L48	R:R:S94	3	No	No	0	9	7
47	R:R:L48	R:R:Y288	4.69	No	Yes	0	9	9
48	R:R:D52	R:R:S281	7.36	Yes	No	2	9	9
49	R:R:D52	R:R:N284	5.39	Yes	Yes	2	9	9
50	R:R:D52	R:R:P285	3.22	Yes	No	2	9	9
51	R:R:A54	R:R:L87	3.15	No	Yes	0	6	7
52	R:R:G56	R:R:V55	3.68	No	Yes	0	7	6
53	R:R:L87	R:R:V55	4.47	Yes	Yes	0	7	6
54	R:R:T88	R:R:V55	3.17	No	Yes	0	6	6
55	R:R:S281	R:R:V55	3.23	No	Yes	0	9	6
56	R:R:G56	R:R:I60	3.53	No	Yes	0	7	6
57	R:R:L58	R:R:V57	2.98	No	No	0	5	5
58	R:R:F83	R:R:L58	8.53	No	No	0	5	5
59	R:R:A59	R:R:V84	3.39	No	No	0	6	6
60	R:R:I60	R:R:P61	3.39	Yes	No	0	6	8
61	R:R:H278	R:R:I60	14.58	Yes	Yes	0	6	6
62	R:R:F62	R:R:I80	15.07	No	No	0	5	6
63	R:R:F62	R:R:F83	3.22	No	No	0	5	5
64	R:R:I64	R:R:T68	3.04	No	No	0	6	5
65	R:R:C77	R:R:I66	3.27	No	No	0	9	4
66	R:R:I66	R:R:I80	4.42	No	No	0	4	6
67	R:R:S67	R:R:Y271	3.82	No	No	1	3	3
68	R:R:A73	R:R:F70	4.16	No	No	0	7	7
69	R:R:C77	R:R:F70	18.15	No	No	0	9	7
70	R:R:C74	R:R:H75	2.95	No	No	0	3	2
71	R:R:L78	R:R:N144	5.49	No	No	0	6	4
72	R:R:L78	R:R:V171	4.47	No	No	0	6	4
73	R:R:F79	R:R:M140	3.73	No	No	0	4	5
74	R:R:A81	R:R:F168	4.16	No	Yes	0	5	4
75	R:R:C82	R:R:P139	5.65	No	Yes	0	5	5
76	R:R:F83	R:R:L87	9.74	No	Yes	0	5	7
77	R:R:F168	R:R:L85	4.87	Yes	No	0	4	4
78	R:R:L85	R:R:Y176	4.69	No	Yes	0	4	6
79	R:R:L87	R:R:V86	2.98	Yes	Yes	0	7	4
80	R:R:F133	R:R:V86	9.18	No	Yes	0	3	4
81	R:R:G136	R:R:V86	3.68	No	Yes	0	6	4
82	R:R:T88	R:R:W246	4.85	No	Yes	1	6	8
83	R:R:F93	R:R:Q89	4.68	No	Yes	0	5	5
84	R:R:I135	R:R:Q89	9.61	Yes	Yes	0	4	5
85	R:R:N181	R:R:Q89	6.6	No	Yes	4	5	5
86	R:R:C185	R:R:Q89	9.16	No	Yes	4	5	5
87	R:R:S90	R:R:W129	11.12	No	Yes	0	6	9
88	R:R:S132	R:R:S90	6.52	No	No	0	7	6
89	R:R:I92	R:R:S91	3.1	Yes	No	0	7	9
90	R:R:I92	R:R:V186	3.07	Yes	No	0	7	7
91	R:R:I92	R:R:P189	3.39	Yes	No	0	7	8
92	R:R:I92	R:R:W246	9.4	Yes	Yes	0	7	8
93	R:R:C128	R:R:F93	4.19	No	No	0	7	5
94	R:R:F93	R:R:L131	3.65	No	Yes	0	5	4
95	R:R:L95	R:R:Y288	5.86	No	Yes	0	8	9
96	R:R:I100	R:R:L96	4.28	No	No	0	6	7
97	R:R:I98	R:R:R102	3.76	No	No	0	8	9
98	R:R:A99	R:R:Y197	4	No	Yes	0	9	9
99	R:R:D101	R:R:Y112	5.75	No	Yes	0	9	7
100	R:R:R107	R:R:Y103	8.23	No	No	0	6	8
101	R:R:V196	R:R:Y103	10.09	No	No	0	7	8
102	R:R:I104	R:R:Y112	3.63	No	Yes	0	5	7
103	R:R:I104	R:R:L115	5.71	No	No	0	5	4
104	R:R:A105	R:R:Y112	9.34	No	Yes	0	8	7
105	R:R:I106	R:R:I200	5.89	No	No	0	8	9
106	R:R:I108	R:R:R107	6.26	No	No	0	5	6
107	R:R:R107	R:R:R199	12.79	No	No	0	6	5
108	R:R:I108	R:R:R111	5.01	No	No	0	5	5
109	R:R:V116	R:R:Y112	11.36	No	Yes	0	7	7
110	R:R:G118	R:R:T117	3.64	No	No	0	1	7
111	R:R:T117	R:R:T119	4.71	No	No	0	7	5
112	R:R:R120	R:R:T117	12.94	No	No	0	5	7
113	R:R:F133	R:R:W129	3.01	No	Yes	0	3	9
114	R:R:I135	R:R:L131	2.85	Yes	Yes	0	4	4
115	R:R:I135	R:R:T138	3.04	Yes	No	0	4	6
116	R:R:F180	R:R:I135	3.77	No	Yes	0	4	4
117	R:R:P139	R:R:T138	3.5	Yes	No	0	5	6
118	R:R:N144	R:R:P139	6.52	No	Yes	0	4	5
119	R:R:P139	R:R:Y176	4.17	Yes	Yes	0	5	6
120	R:R:P173	R:R:W143	4.05	Yes	No	3	4	5
121	R:R:N175	R:R:W143	10.17	No	No	3	4	5
122	R:R:W143	R:R:Y176	16.4	No	Yes	3	5	6
123	R:R:N144	R:R:P173	3.26	No	Yes	0	4	4
124	R:R:F168	R:R:V172	15.73	Yes	No	0	4	3
125	R:R:F168	R:R:M177	4.98	Yes	No	0	4	6
126	R:R:E169	R:R:M174	6.77	No	No	0	3	4
127	R:R:E169	R:R:H264	4.92	No	No	0	3	2
128	R:R:P173	R:R:V172	5.3	Yes	No	0	4	3
129	R:R:N175	R:R:P173	4.89	No	Yes	3	4	4
130	R:R:P173	R:R:Y176	5.56	Yes	Yes	3	4	6
131	R:R:F257	R:R:M174	6.22	No	No	0	3	4
132	R:R:F180	R:R:Y176	6.19	No	Yes	0	4	6
133	R:R:M177	R:R:N181	4.21	No	No	0	6	5
134	R:R:V178	R:R:Y179	5.05	No	No	0	5	5
135	R:R:F257	R:R:V178	6.55	No	No	0	3	5
136	R:R:C185	R:R:N181	4.72	No	No	4	5	5
137	R:R:F182	R:R:V186	3.93	No	No	1	5	7
138	R:R:F182	R:R:L187	6.09	No	No	0	5	4
139	R:R:F182	R:R:H250	7.92	No	No	1	5	6
140	R:R:H250	R:R:V186	4.15	No	No	1	6	7
141	R:R:P189	R:R:V188	3.53	No	No	0	8	5
142	R:R:L192	R:R:V188	2.98	No	No	0	6	5
143	R:R:F242	R:R:L190	6.09	No	No	0	9	6
144	R:R:G195	R:R:L194	3.42	No	No	0	4	4
145	R:R:V196	R:R:Y197	3.79	No	Yes	0	7	9
146	R:R:L235	R:R:Y197	5.86	Yes	Yes	0	8	9
147	R:R:I238	R:R:Y197	6.04	No	Yes	0	8	9
148	R:R:I200	R:R:L235	2.85	No	Yes	0	9	8
149	R:R:A232	R:R:F201	4.16	No	Yes	0	7	5
150	R:R:L202	R:R:R205	3.64	No	No	0	4	5
151	R:R:Q210	R:R:R206	7.01	No	No	0	3	4
152	R:R:M211	R:R:Q207	4.08	No	No	0	4	6
153	R:R:E212	R:R:L208	6.63	No	No	0	2	5
154	R:R:K227	R:R:L208	5.64	No	No	0	6	5
155	R:R:M211	R:R:Q210	8.16	No	No	0	4	3
156	R:R:K227	R:R:S223	3.06	No	No	0	6	4
157	R:R:E228	R:R:T224	4.23	No	No	0	7	5
158	R:R:L235	R:R:S234	4.5	Yes	No	0	8	8
159	R:R:I238	R:R:I287	2.94	No	Yes	0	8	8
160	R:R:G240	R:R:V239	3.68	No	No	0	5	8
161	R:R:C245	R:R:L241	3.17	No	No	0	8	7
162	R:R:I287	R:R:L241	2.85	Yes	No	0	8	7
163	R:R:F242	R:R:W246	5.01	No	Yes	0	9	8
164	R:R:C245	R:R:N280	3.15	No	No	0	8	9
165	R:R:H250	R:R:W246	5.29	No	Yes	1	6	8
166	R:R:N280	R:R:W246	12.43	No	Yes	0	9	8
167	R:R:L249	R:R:N253	5.49	No	No	1	5	5
168	R:R:A273	R:R:L249	3.15	No	No	0	6	5
169	R:R:I252	R:R:T256	3.04	No	No	0	5	4
170	R:R:A265	R:R:I252	3.25	No	No	0	4	5
171	R:R:C254	R:R:F255	4.19	No	No	0	6	4
172	R:R:H264	R:R:T256	5.48	No	No	0	2	4
173	R:R:F257	R:R:F258	7.5	No	No	0	3	6
174	R:R:C259	R:R:D261	6.22	No	No	0	4	1
175	R:R:C259	R:R:C262	7.28	No	No	0	4	1
176	R:R:D261	R:R:P260	3.22	No	No	0	1	1
177	R:R:H264	R:R:M270	3.94	No	No	0	2	4
178	R:R:P266	R:R:W268	20.27	No	No	5	3	1
179	R:R:L269	R:R:P266	8.21	No	No	5	4	3
180	R:R:L267	R:R:Y271	9.38	No	No	0	3	3
181	R:R:L269	R:R:W268	7.97	No	No	5	4	1
182	R:R:H278	R:R:I274	3.98	Yes	Yes	1	6	4
183	R:R:H278	R:R:S277	4.18	Yes	No	0	6	7
184	R:R:N280	R:R:N284	5.45	No	Yes	0	9	9
185	R:R:N284	R:R:S281	2.98	Yes	No	2	9	9
186	R:R:F286	R:R:V283	3.93	No	No	0	6	6
187	R:R:I287	R:R:V283	3.07	Yes	No	0	8	6
188	R:R:N284	R:R:P285	4.89	Yes	No	2	9	9
189	R:R:F286	R:R:Y290	11.35	No	No	0	6	6
190	R:R:I287	R:R:Y288	7.25	Yes	Yes	0	8	9
191	R:R:A289	R:R:F295	4.16	No	Yes	0	7	8
192	R:R:R296	R:R:Y290	5.14	No	No	6	8	6
193	R:R:F299	R:R:Y290	6.19	Yes	No	6	6	6
194	R:R:E294	R:R:I292	6.83	No	No	0	6	8
195	R:R:F295	R:R:F299	8.57	Yes	Yes	0	8	6
196	R:R:F299	R:R:R296	5.34	Yes	No	6	6	8
197	R:R:K301	R:R:Q297	6.78	No	No	0	4	4
198	R:R:F299	R:R:R300	6.41	Yes	No	0	6	5
199	R:R:A121	R:R:F44	2.77	No	Yes	0	7	7
200	R:R:L192	R:R:L96	2.77	No	No	0	6	7
201	R:R:L198	R:R:L202	2.77	No	No	0	4	4
202	R:R:A231	R:R:F201	2.77	No	Yes	0	8	5
203	R:R:A51	R:R:W129	2.59	No	Yes	0	8	9
204	R:R:F62	R:R:T65	2.59	No	No	0	5	5
205	R:R:F295	R:R:T298	2.59	Yes	No	0	8	7
206	R:R:H75	R:R:L78	2.57	No	No	0	2	6
207	R:R:F242	R:R:M193	2.49	No	No	0	9	8
208	R:R:L198	R:R:R199	2.43	No	No	0	4	5
209	R:R:I98	R:R:Y288	2.42	No	Yes	0	8	9
210	R:R:I125	R:R:W129	2.35	No	Yes	0	8	9
211	L:L:?1	R:R:V84	1.97	Yes	No	0	0	6
212	R:R:A121	R:R:G118	1.95	No	No	0	7	1
213	R:R:A243	R:R:G240	1.95	No	No	0	5	5
214	R:R:A273	R:R:P248	1.87	No	No	0	6	9
215	R:R:A265	R:R:P266	1.87	No	No	0	4	3
216	R:R:G69	R:R:T68	1.82	No	No	0	4	5
217	R:R:A97	R:R:C128	1.81	No	No	0	7	7
218	R:R:G76	R:R:I80	1.76	No	No	0	6	6
219	R:R:G118	R:R:K122	1.74	No	No	0	1	3
220	R:R:G23	R:R:L22	1.71	No	No	0	9	5
221	R:R:G23	R:R:L26	1.71	No	No	0	9	6
222	R:R:G69	R:R:L167	1.71	No	No	0	4	4
223	R:R:C254	R:R:V178	1.71	No	No	0	6	5
224	R:R:G195	R:R:L198	1.71	No	No	0	4	4
225	R:R:A20	R:R:V282	1.7	No	No	0	7	7
226	R:R:G114	R:R:N113	1.7	No	No	0	5	5
227	R:R:I108	R:R:P109	1.69	No	No	0	5	8
228	R:R:L247	R:R:P248	1.64	No	No	0	6	9
229	R:R:L276	R:R:P248	1.64	No	No	0	7	9
230	R:R:C254	R:R:I251	1.64	No	No	0	6	5
231	R:R:S47	R:R:V46	1.62	No	No	0	9	5
232	R:R:C82	R:R:M140	1.62	No	No	0	5	5
233	R:R:A203	R:R:I106	1.62	No	No	0	6	8
234	R:R:T279	R:R:V283	1.59	No	No	0	5	6
235	R:R:A243	R:R:L190	1.58	No	No	0	5	6
236	R:R:A243	R:R:L247	1.58	No	No	0	5	6
237	R:R:I10	R:R:S7	1.55	No	No	0	6	4
238	R:R:I64	R:R:S67	1.55	No	No	0	6	3
239	R:R:I21	R:R:V25	1.54	No	No	0	6	4
240	R:R:I53	R:R:V25	1.54	No	No	0	7	4
241	R:R:A63	R:R:E13	1.51	No	Yes	0	5	6
242	R:R:L19	R:R:V18	1.49	No	No	0	5	4
243	R:R:L22	R:R:V18	1.49	No	No	0	5	4
244	R:R:L137	R:R:V86	1.49	No	Yes	0	3	4
245	R:R:L131	R:R:V130	1.49	Yes	No	0	4	4
246	R:R:L272	R:R:V275	1.49	No	No	0	5	5
247	R:R:L208	R:R:T224	1.47	No	No	0	5	5
248	R:R:I237	R:R:I238	1.47	No	No	0	6	8
249	R:R:I127	R:R:L131	1.43	No	Yes	0	3	4
250	R:R:L190	R:R:L191	1.38	No	No	0	6	3
251	R:R:E294	R:R:L37	1.33	No	No	0	6	8
252	R:R:L225	R:R:Q226	1.33	No	No	0	4	4
253	R:R:E228	R:R:L225	1.33	No	No	0	7	4
254	R:R:C28	R:R:W32	1.31	No	No	0	7	3
255	R:R:D170	R:R:E169	1.3	No	No	0	4	3
256	R:R:I303	R:R:R300	1.25	No	No	0	6	5
257	R:R:F183	R:R:L187	1.22	No	No	0	4	4
258	R:R:F201	R:R:L235	1.22	Yes	Yes	0	5	8
259	R:R:L202	R:R:R206	1.21	No	No	0	4	4
260	R:R:K122	R:R:Y43	1.19	No	No	0	3	5
261	R:R:E228	R:R:F201	1.17	No	Yes	0	7	5
262	R:R:W29	R:R:W32	0.94	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.20778	9	1	0
2	R:R:Y9	12.42	4	1	5
3	R:R:E13	8.32	5	1	6
4	R:R:N24	7.76	5	2	9
5	R:R:F44	5.265	4	0	7
6	R:R:D52	7.695	4	2	9
7	R:R:V55	3.6375	4	0	6
8	R:R:I60	6.5925	4	0	6
9	R:R:V86	4.3325	4	0	4
10	R:R:L87	5.085	4	0	7
11	R:R:Q89	7.5125	4	4	5
12	R:R:I92	4.74	4	0	7
13	R:R:Y112	7.52	4	0	7
14	R:R:W129	4.7675	4	0	9
15	R:R:L131	2.355	4	0	4
16	R:R:I135	4.8175	4	0	4
17	R:R:P139	4.96	4	0	5
18	R:R:F168	8.36	5	0	4
19	R:R:P173	4.612	5	3	4
20	R:R:Y176	7.402	5	3	6
21	R:R:Y197	4.9225	4	0	9
22	R:R:F201	2.33	4	0	5
23	R:R:L235	3.6075	4	0	8
24	R:R:W246	7.16667	6	1	8
25	R:R:I274	6.3575	4	1	4
26	R:R:H278	9.685	4	1	6
27	R:R:N284	4.6775	4	2	9
28	R:R:I287	4.0275	4	0	8
29	R:R:Y288	5.055	4	0	9
30	R:R:F295	4.87	5	0	8
31	R:R:F299	6.6275	4	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I274	37.4438	11.31	Yes	Yes	1	0	4
2	R:R:E13	R:R:I274	16.2753	4.1	Yes	Yes	1	6	4
3	R:R:I274	R:R:Y9	16.4932	6.04	Yes	Yes	1	4	5
4	R:R:S67	R:R:Y9	13.7725	5.09	No	Yes	1	3	5
5	R:R:I64	R:R:S67	12.1977	1.55	No	No	0	6	3
6	R:R:E13	R:R:V275	19.6639	4.28	Yes	No	0	6	5
7	R:R:V12	R:R:V275	16.0785	3.21	No	No	0	5	5
8	R:R:I16	R:R:V12	14.2787	3.07	No	No	0	7	5
9	R:R:I16	R:R:V282	12.4859	4.61	No	No	0	7	7
10	R:R:H278	R:R:I60	12.0571	14.58	Yes	Yes	0	6	6
11	L:L:?1	R:R:T88	34.5894	3.89	Yes	No	1	0	6
12	R:R:T88	R:R:V55	64.3771	3.17	No	Yes	0	6	6
13	R:R:L87	R:R:V55	84.3082	4.47	Yes	Yes	0	7	6
14	R:R:F83	R:R:L87	24.065	9.74	No	Yes	0	5	7
15	R:R:S281	R:R:V55	30.1392	3.23	No	Yes	0	9	6
16	R:R:D52	R:R:N24	12.2539	14.81	Yes	Yes	2	9	9
17	L:L:?1	R:R:W246	60.7002	6.02	Yes	Yes	1	0	8
18	R:R:N280	R:R:W246	81.5523	12.43	No	Yes	0	9	8
19	R:R:N280	R:R:N284	40.7691	5.45	No	Yes	0	9	9
20	R:R:C245	R:R:N280	100	3.15	No	No	0	8	9
21	R:R:C245	R:R:L241	98.7908	3.17	No	No	0	8	7
22	R:R:I287	R:R:L241	97.5534	2.85	Yes	No	0	8	7
23	R:R:I287	R:R:V283	34.1535	3.07	Yes	No	0	8	6
24	R:R:F286	R:R:V283	30.5681	3.93	No	No	0	6	6
25	R:R:F286	R:R:Y290	28.7683	11.35	No	No	0	6	6
26	R:R:F299	R:R:Y290	25.0141	6.19	Yes	No	6	6	6
27	R:R:F295	R:R:F299	19.9733	8.57	Yes	Yes	0	8	6
28	R:R:L87	R:R:V86	62.9007	2.98	Yes	Yes	0	7	4
29	R:R:F133	R:R:V86	57.5436	9.18	No	Yes	0	3	4
30	R:R:F133	R:R:W129	55.7298	3.01	No	Yes	0	3	9
31	R:R:I125	R:R:W129	48.3338	2.35	No	Yes	0	8	9
32	R:R:F295	R:R:T298	11.8673	2.59	Yes	No	0	8	7
33	R:R:F44	R:R:I125	39.0115	3.77	Yes	No	0	7	8
34	R:R:D101	R:R:F44	20.8661	10.75	No	Yes	0	9	7
35	R:R:D101	R:R:Y112	14.8411	5.75	No	Yes	0	9	7
36	R:R:I287	R:R:Y288	12.2328	7.25	Yes	Yes	0	8	9
37	R:R:G56	R:R:V55	10.7424	3.68	No	Yes	0	7	6
38	R:R:F62	R:R:F83	16.9783	3.22	No	No	0	5	5
39	R:R:F62	R:R:I80	13.0273	15.07	No	No	0	5	6
40	L:L:?1	R:R:F168	56.2922	12.06	Yes	Yes	0	0	4
41	R:R:F168	R:R:V172	13.9061	15.73	Yes	No	0	4	3
42	R:R:P173	R:R:V172	12.493	5.3	Yes	No	0	4	3
43	R:R:F168	R:R:L85	19.3898	4.87	Yes	No	0	4	4
44	R:R:L85	R:R:Y176	18.2016	4.69	No	Yes	0	4	6
45	R:R:F168	R:R:M177	21.3301	4.98	Yes	No	0	4	6
46	R:R:M177	R:R:N181	20.0014	4.21	No	No	0	6	5
47	R:R:N181	R:R:Q89	16.9854	6.6	No	Yes	4	5	5
48	R:R:I92	R:R:W246	13.5405	9.4	Yes	Yes	0	7	8
49	R:R:I135	R:R:L131	10.0112	2.85	Yes	Yes	0	4	4
50	R:R:I238	R:R:I287	66.3737	2.94	No	Yes	0	8	8
51	R:R:I238	R:R:Y197	63.1398	6.04	No	Yes	0	8	9
52	R:R:V196	R:R:Y197	32.3889	3.79	No	Yes	0	7	9
53	R:R:V196	R:R:Y103	30.4696	10.09	No	No	0	7	8
54	R:R:R107	R:R:Y103	28.5363	8.23	No	No	0	6	8
55	R:R:L235	R:R:Y197	31.2289	5.86	Yes	Yes	0	8	9
56	R:R:R107	R:R:R199	20.6623	12.79	No	No	0	6	5
57	R:R:A121	R:R:F44	15.1294	2.77	No	Yes	0	7	7
58	R:R:A121	R:R:G118	13.0273	1.95	No	No	0	7	1
59	L:L:?1	R:R:M270	28.7683	3.73	Yes	No	0	0	4
60	R:R:H264	R:R:M270	27.4184	3.94	No	No	0	2	4
61	R:R:E169	R:R:H264	16.4932	4.92	No	No	0	3	2
62	R:R:E169	R:R:M174	13.3577	6.77	No	No	0	3	4
63	R:R:F257	R:R:M174	11.8813	6.22	No	No	0	3	4
64	R:R:F242	R:R:W246	12.9078	5.01	No	Yes	0	9	8
65	R:R:L198	R:R:R199	18.6586	2.43	No	No	0	4	5
66	R:R:F201	R:R:L235	21.6606	1.22	Yes	Yes	0	5	8
67	R:R:L198	R:R:L202	12.5633	2.77	No	No	0	4	4
68	R:R:E228	R:R:F201	16.1277	1.17	No	Yes	0	7	5
69	R:R:E228	R:R:T224	10.2503	4.23	No	No	0	7	5
70	R:R:H264	R:R:T256	10.412	5.48	No	No	0	2	4
71	R:R:N284	R:R:S281	23.2565	2.98	Yes	No	2	9	9
72	R:R:T88	R:R:W246	30.5118	4.85	No	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T88	3.89	1	Yes	No	0	6	0	1
L:L:?1	R:R:F168	12.06	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:W246	6.02	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L249	24.67	1	Yes	No	0	5	0	1
L:L:?1	R:R:N253	7.25	1	Yes	No	0	5	0	1
L:L:?1	R:R:M270	3.73	1	Yes	No	0	4	0	1
L:L:?1	R:R:I274	11.31	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S277	2.97	1	Yes	No	0	7	0	1
R:R:E13	R:R:Y9	15.71	1	Yes	Yes	6	5	2	2
R:R:I274	R:R:Y9	6.04	1	Yes	Yes	4	5	1	2
R:R:E13	R:R:I274	4.1	1	Yes	Yes	6	4	2	1
R:R:E13	R:R:H278	16	1	Yes	Yes	6	6	2	2
R:R:T88	R:R:V55	3.17	1	No	Yes	6	6	1	2
R:R:A59	R:R:V84	3.39	0	No	No	6	6	2	1
R:R:A81	R:R:F168	4.16	0	No	Yes	5	4	2	1
R:R:F168	R:R:L85	4.87	0	Yes	No	4	4	1	2
R:R:T88	R:R:W246	4.85	1	No	Yes	6	8	1	1
R:R:I92	R:R:W246	9.4	0	Yes	Yes	7	8	2	1
R:R:F168	R:R:V172	15.73	0	Yes	No	4	3	1	2
R:R:F168	R:R:M177	4.98	0	Yes	No	4	6	1	2
R:R:F242	R:R:W246	5.01	0	No	Yes	9	8	2	1
R:R:H250	R:R:W246	5.29	1	No	Yes	6	8	2	1
R:R:N280	R:R:W246	12.43	0	No	Yes	9	8	2	1
R:R:L249	R:R:N253	5.49	1	No	No	5	5	1	1
R:R:A273	R:R:L249	3.15	0	No	No	6	5	2	1
R:R:H264	R:R:M270	3.94	0	No	No	2	4	2	1
R:R:H278	R:R:I274	3.98	1	Yes	Yes	6	4	2	1
R:R:H278	R:R:S277	4.18	1	Yes	No	6	7	2	1
L:L:?1	R:R:V84	1.97	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9EEA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	241
Number of Links	262
Number of Hubs	31
Number of Links mediated by Hubs	115
Number of Communities	6
Number of Nodes involved in Communities	32
Number of Links involved in Communities	40

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	33663
Length Of Smallest Path	3
Average Path Length	13.0223
Length of Longest Path	30
Minimum Path Strength	1.125
Average Path Strength	5.47638
Maximum Path Strength	19.275
Minimum Path Correlation	0.7
Average Path Correlation	0.92294
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	44.9929
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.1321
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled adenosine receptor activity • protein-containing complex binding • binding • protein binding • calmodulin binding • identical protein binding • cytoskeletal protein binding • alpha-actinin binding • actinin binding • lipid binding • type 5 metabotropic glutamate receptor binding • signaling receptor binding • glutamate receptor binding • G protein-coupled receptor binding • G protein-coupled glutamate receptor binding • enzyme binding • response to stimulus • response to chemical • response to xenobiotic stimulus • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • biological regulation • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of cellular process
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • biological regulation • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of cellular process • regulation of alpha-beta T cell activation • regulation of leukocyte activation • negative regulation of biological process • regulation of cell activation • lymphocyte activation • negative regulation of lymphocyte activation • leukocyte cell-cell adhesion • negative regulation of cell adhesion • leukocyte activation • cell adhesion • cell-cell adhesion • T cell activation • negative regulation of cellular process • alpha-beta T cell activation • regulation of immune system process • regulation of multicellular organismal process • regulation of cell-cell adhesion • regulation of biological process • regulation of cell adhesion • cell activation • regulation of T cell activation • negative regulation of cell activation • negative regulation of T cell activation • negative regulation of immune system process • negative regulation of leukocyte cell-cell adhesion • immune system process • negative regulation of cell-cell adhesion • regulation of leukocyte cell-cell adhesion • cellular process • negative regulation of alpha-beta T cell activation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • regulation of lymphocyte activation • developmental process • multicellular organism development • central nervous system development • anatomical structure development • nervous system development • system development • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • signaling • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • cell communication • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • regulation of programmed cell death • positive regulation of apoptotic signaling pathway • positive regulation of response to stimulus • signal transduction • positive regulation of cellular process • positive regulation of programmed cell death • regulation of apoptotic process • cell death • positive regulation of apoptotic process • apoptotic signaling pathway • regulation of response to stimulus • apoptotic process • programmed cell death • positive regulation of signaling • regulation of apoptotic signaling pathway • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • import into cell • phagocytosis • endocytosis • vesicle-mediated transport • response to nitrogen compound • response to purine-containing compound • response to caffeine • response to alkaloid • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • system process • sensory perception • nervous system process • negative regulation of vascular permeability • regulation of vascular permeability • circulatory system process • vascular process in circulatory system • blood circulation • startle response • regulation of response to external stimulus • neuromuscular process • negative regulation of response to stimulus • prepulse inhibition • response to external stimulus • negative regulation of response to external stimulus • nitrogen compound transport • positive regulation of neurotransmitter secretion • positive regulation of amine transport • acetylcholine secretion, neurotransmission • establishment of localization in cell • positive regulation of acetylcholine secretion, neurotransmission • positive regulation of neurotransmitter transport • positive regulation of synaptic transmission, cholinergic • neurotransmitter secretion • positive regulation of synaptic transmission • regulation of acetylcholine secretion, neurotransmission • neurotransmitter transport • organic cation transport • acetate ester transport • regulation of secretion • signal release from synapse • acetylcholine transport • cellular localization • positive regulation of secretion by cell • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • acetylcholine secretion • secretion • regulation of neurotransmitter transport • export from cell • amine transport • positive regulation of transport • regulation of neurotransmitter secretion • synaptic transmission, cholinergic • regulation of amine transport • regulation of synaptic transmission, cholinergic • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • defense response • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • synaptic transmission, dopaminergic • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • inhibitory postsynaptic potential • regulation of membrane potential • cellular defense response • behavior • locomotory behavior • intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • long-term synaptic potentiation • positive regulation of long-term synaptic potentiation • regulation of synaptic plasticity • regulation of long-term synaptic potentiation • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of synaptic transmission, glutamatergic • regulation of mitochondrial membrane potential • positive regulation of synaptic transmission, GABAergic • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • regulation of defense response • negative regulation of inflammatory response • regulation of inflammatory response • regulation of response to stress • negative regulation of defense response • renal system process • positive regulation of urine volume • regulation of urine volume • eating behavior • feeding behavior • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • circadian behavior • positive regulation of behavior • positive regulation of circadian rhythm • positive regulation of multicellular organismal process • sleep • positive regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • catecholamine transport • norepinephrine transport • catecholamine secretion • norepinephrine secretion • regulation of norepinephrine secretion • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • negative regulation of apoptotic process • regulation of neuron apoptotic process • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • generation of neurons • anatomical structure morphogenesis • neuron development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of tube diameter • regulation of tube size • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • excitatory postsynaptic potential • establishment of protein localization • regulation of protein localization • positive regulation of establishment of protein localization • protein localization to extracellular region • positive regulation of protein transport • intracellular protein localization • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • positive regulation of protein secretion • regulation of protein secretion • protein transport • macromolecule localization • positive regulation of protein localization • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • response to amine • response to amphetamine • membrane depolarization • regulation of glutamate secretion • regulation of amino acid transport • glutamate secretion • organic anion transport • carboxylic acid transport • positive regulation of glutamate secretion • positive regulation of organic acid transport • organic acid transport • amino acid transport • acidic amino acid transport • positive regulation of amino acid transport • regulation of organic acid transport • dicarboxylic acid transport • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic active zone • presynaptic membrane • somatodendritic compartment
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • presynapse • presynaptic active zone • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • glutamatergic synapse • axon • cell leading edge • axolemma • leading edge membrane • neuron projection membrane • main axon • cell projection membrane • cell body • neuronal cell body • polymeric cytoskeletal fiber • intracellular anatomical structure • intracellular membraneless organelle • intermediate filament cytoskeleton • intracellular organelle • cytoskeleton • organelle • membraneless organelle • intermediate filament • supramolecular fiber • supramolecular polymer • supramolecular complex • neuron to neuron synapse • asymmetric synapse • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ADN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ADN
Name	Adenosine
Synonyms	Ado
Identifier
Formula	C10 H13 N5 O4
Molecular Weight	267.241
SMILES
PubChem	60961
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	4
Total Bonds	34
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P29274
Sequence	>9EEA_nogp_Chain_R S V Y I T V E L A I A V L A I L G N V L V C W A V W L N S N L Q N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G F C A A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I P L R Y N G L V T G T R A K G I I A I C W V L S F A I G L T P M L G W N L F E D V V P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S T L Q K E H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P D C S H A P L W L M Y L A I V L S H T N S V V N P F I Y A Y I R E F R Q T F R K I I C A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ZDR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	HMS1413f12	Na	-	1.92	2020-09-16	doi.org/10.1002/anie.202003788
	6ZDV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Chromone 5d	Na	-	2.13	2020-09-16	doi.org/10.1002/anie.202003788
	8JWZ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	AB928	Na	-	2.37	2023-08-16	doi.org/10.1007/s11427-023-2459-8
	5MZJ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	Na	-	2	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	5MZP	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Caffeine	Na	-	2.1	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	5N2R	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-36	Na	-	2.8	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	7ARO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUF5833	Na	-	3.12	2021-04-07	doi.org/10.1021/acs.jmedchem.0c01856
	8CU7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LJ-4517	Na	-	2.05	2022-08-31	doi.org/10.1021/acs.jmedchem.2c00462
	5IU4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.72	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IU7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456346	Na	-	1.9	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IU8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456347	Na	-	2	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IUA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456348	Na	-	2.2	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IUB	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456344	Na	-	2.1	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5VRA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.35	2017-12-13	doi.org/10.1038/nprot.2017.135
	5NLX	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.14	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5NM2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.95	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	8FYN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2023-03-08	doi.org/10.1038/s41467-023-36733-4
	8RW0	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	Na	-	1.94	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	5OLG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.87	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Vipadenant	Na	-	2.6	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Tozadenant	Na	-	3.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUAA41063	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLZ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	1.9	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OM1	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	6LPJ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	6LPK	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	6LPL	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	8CIC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Etrumadenant	Na	-	2.1	2023-05-31	doi.org/10.1038/s42004-023-00894-6
	7RM5	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.79	2021-09-08	doi.org/10.1073/pnas.2106041118
	6JZH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.25	2019-10-30	doi.org/10.1107/S1600576719012846
	8A2O	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	Na	-	3.45	2023-08-30	doi.org/10.1107/S1600576723006428
	8A2P	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUAA47070	Na	-	3.5	2023-08-30	doi.org/10.1107/S1600576723006428
	6PS7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.85	2019-11-13	doi.org/10.1107/S2052252519013137
	6WQA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2020-11-18	doi.org/10.1107/S2052252520012701
	8GNE	A	Nucleotide	Adenosine	A_2A	Homo sapiens	KW-6356	Na	-	2.3	2023-03-22	doi.org/10.1124/molpharm.122.000633
	5K2A	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.5	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2B	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.5	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2C	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.9	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2D	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.9	2016-09-21	doi.org/10.1126/sciadv.1600292
	4EIY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2012-07-25	doi.org/10.1126/science.1219218
	6GT3	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Imaradenant	Na	-	2	2019-06-26	doi.org/10.1136/jitc-2019-000417
	8RQQ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.37	2024-04-03	doi.org/10.1021/acs.cgd.4c00087
	8RVW	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	2.65	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RW4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	AzoSwitch2	Na	-	2.2	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RW7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch1	Na	-	2.25	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.31	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWD	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	2.05	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWE	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch4	Na	-	2.2	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.45	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWI	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.8	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWX	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	3.05	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	9FUP	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	Na	-	2.5	2025-01-22	doi.org/10.1038/s42004-024-01404-y
	9H2X	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR1	Na	-	1.75	2025-06-18	To be published
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR0	Na	-	1.71	2025-06-18	To be published
	3VG9	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Antibody	-	2.7	2012-02-01	doi.org/10.1038/nature10750
	3VGA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Antibody	-	3.1	2012-02-01	doi.org/10.1038/nature10750
	7PX4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-2113	-	-	2.25	2022-03-02	doi.org/10.1002/anie.202115545
	7PYR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-2115	-	-	2.6	2022-03-02	doi.org/10.1002/anie.202115545
	8JWY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	2-118	-	-	2.33	2023-08-16	doi.org/10.1007/s11427-023-2459-8
	6AQF	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.51	2018-01-10	doi.org/10.1016/j.cell.2017.12.004
	8DU3	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 105526064	-	-	2.5	2022-08-10	doi.org/10.1016/j.ejmech.2022.114620
	3PWH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.3	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	3REY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	XAC	-	-	3.31	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	3RFM	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Caffeine	-	-	3.6	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	5WF5	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.6	2018-02-21	doi.org/10.1016/j.str.2017.12.013
	5WF6	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.9	2018-02-21	doi.org/10.1016/j.str.2017.12.013
	8CU6	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LJ-4517	-	-	2.8	2022-08-31	doi.org/10.1021/acs.jmedchem.2c00462
	3UZA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	GTPL9236	-	-	3.27	2012-03-21	doi.org/10.1021/jm201376w
	3UZC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	-	-	3.34	2012-03-21	doi.org/10.1021/jm201376w
	2YDO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	-	3	2011-05-18	doi.org/10.1038/nature10136
	2YDV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	-	2.6	2011-05-18	doi.org/10.1038/nature10136
	5G53	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	Gs	3.4	2016-08-03	doi.org/10.1038/nature18966
	5G53 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-		3.4	2016-08-03	doi.org/10.1038/nature18966
	7T32	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.4	2022-08-10	doi.org/10.1038/s41467-022-32125-2
	8C9W	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Etrumadenant	-	-	2.11	2023-07-12	doi.org/10.1038/s42004-023-00894-6
	8PWN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	-	-	2.75	2023-10-25	doi.org/10.1038/s42004-023-01014-0
	5UIG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Cmpd-1	-	-	3.5	2017-02-08	doi.org/10.1073/pnas.1621423114
	5UVI	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.2	2017-05-24	doi.org/10.1107/S205225251700570X
	6MH8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	4.2	2019-04-24	doi.org/10.1107/S205225251900263X
	6S0L	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.65	2020-07-15	doi.org/10.1107/S2052252520011379
	6S0Q	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.65	2020-07-15	doi.org/10.1107/S2052252520011379
	7EZC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UKA	-	-	3.8	2022-04-13	doi.org/10.1107/S2052252522001907
	4UG2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	CGS21680	-	-	2.6	2015-04-08	doi.org/10.1124/mol.114.097360
	4UHR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	CGS21680	-	-	2.6	2015-04-08	doi.org/10.1124/mol.114.097360
	8GNG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	-	-	3.2	2023-03-22	doi.org/10.1124/molpharm.122.000633
	5JTB	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.8	2017-05-31	doi.org/10.1126/sciadv.1602952
	3EML	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.6	2008-10-14	doi.org/10.1126/science.1164772
	3QAK	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.71	2011-03-09	doi.org/10.1126/science.1202793
	6GDG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	Gs/β1/γ1	4.11	2018-05-16	doi.org/10.7554/eLife.35946
	6GDG (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-		4.11	2018-05-16	doi.org/10.7554/eLife.35946
	8WDT	A	Nucleotide	Adenosine	A_2A	Homo sapiens	photoNECA	-	-	3.34	2024-01-17	doi.org/10.1016/j.bbrc.2023.149393
	8RLN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUF5834	-	-	2.43	2024-06-19	doi.org/10.1021/acsptsci.4c00051
	9EE8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	2.63	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE8 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		2.63	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE9	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	3.16	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE9 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		3.16	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EEA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	3.36	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EEA (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		3.36	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	8UGW	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 3086599	-	-	3.9	2024-12-18	doi.org/10.1038/s41557-024-01719-2

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