psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:V84	5.17	Yes	No	0	0	6
2	L:L:?2	R:R:L85	5.76	Yes	Yes	1	0	4
3	L:L:?2	R:R:T88	10.23	Yes	No	1	0	6
4	L:L:?2	R:R:F168	34.66	Yes	Yes	1	0	4
5	L:L:?2	R:R:E169	5.52	Yes	Yes	1	0	3
6	L:L:?2	R:R:N181	4.76	Yes	Yes	1	0	5
7	L:L:?2	R:R:W246	11.86	Yes	Yes	1	0	8
8	L:L:?2	R:R:L249	15.37	Yes	No	1	0	5
9	L:L:?2	R:R:H250	6.25	Yes	Yes	1	0	6
10	L:L:?2	R:R:N253	9.53	Yes	No	1	0	5
11	L:L:?2	R:R:I274	6.93	Yes	No	1	0	4
12	L:L:?2	R:R:S277	5.21	Yes	No	1	0	7
13	L:L:?2	R:R:H278	9.82	Yes	Yes	1	0	6
14	R:R:E13	R:R:Y9	13.47	Yes	Yes	1	6	5
15	R:R:S67	R:R:Y9	10.17	No	Yes	1	3	5
16	R:R:Y271	R:R:Y9	30.78	Yes	Yes	1	3	5
17	R:R:I274	R:R:Y9	4.84	No	Yes	1	4	5
18	R:R:I10	R:R:I64	4.42	No	No	0	6	6
19	R:R:E13	R:R:I60	6.83	Yes	Yes	1	6	6
20	R:R:E13	R:R:I64	5.47	Yes	No	0	6	6
21	R:R:E13	R:R:V275	4.28	Yes	No	0	6	5
22	R:R:E13	R:R:H278	12.31	Yes	Yes	1	6	6
23	R:R:I64	R:R:L14	4.28	No	No	0	6	5
24	R:R:A17	R:R:I60	4.87	No	Yes	0	6	6
25	R:R:G56	R:R:I21	3.53	No	No	0	7	6
26	R:R:I21	R:R:V57	4.61	No	No	0	6	5
27	R:R:A49	R:R:N24	4.69	No	Yes	0	9	9
28	R:R:D52	R:R:N24	12.12	Yes	Yes	0	9	9
29	R:R:I53	R:R:N24	4.25	No	Yes	0	7	9
30	R:R:N24	R:R:P285	13.03	Yes	No	0	9	9
31	R:R:F299	R:R:L26	8.53	No	No	0	6	6
32	R:R:A49	R:R:V27	3.39	No	No	0	9	9
33	R:R:A289	R:R:V27	3.39	No	No	0	7	9
34	R:R:L33	R:R:W29	3.42	No	No	0	5	4
35	R:R:L37	R:R:V31	4.47	Yes	No	0	8	7
36	R:R:V31	R:R:V46	4.81	No	No	0	7	5
37	R:R:N34	R:R:N36	5.45	Yes	No	2	6	5
38	R:R:L37	R:R:N34	9.61	Yes	Yes	2	8	6
39	R:R:E294	R:R:N34	6.57	No	Yes	2	6	6
40	R:R:N34	R:R:T298	8.77	Yes	No	0	6	7
41	R:R:E294	R:R:N36	13.15	No	No	2	6	5
42	R:R:L37	R:R:N42	4.12	Yes	Yes	2	8	8
43	R:R:E294	R:R:L37	3.98	No	Yes	2	6	8
44	R:R:F295	R:R:L37	12.18	Yes	Yes	2	8	8
45	R:R:N39	R:R:N42	5.45	No	Yes	2	7	8
46	R:R:G118	R:R:V40	3.68	Yes	No	0	1	6
47	R:R:D101	R:R:T41	5.78	No	Yes	2	9	8
48	R:R:T41	R:R:Y112	6.24	Yes	Yes	2	8	7
49	R:R:F295	R:R:N42	4.83	Yes	Yes	2	8	8
50	R:R:D101	R:R:F44	10.75	No	Yes	0	9	7
51	R:R:A121	R:R:F44	4.16	No	Yes	0	7	7
52	R:R:F44	R:R:I124	5.02	Yes	No	0	7	5
53	R:R:F44	R:R:I125	3.77	Yes	No	0	7	8
54	R:R:S47	R:R:S94	4.89	No	No	0	9	7
55	R:R:I125	R:R:S47	9.29	No	No	0	8	9
56	R:R:D52	R:R:L48	5.43	Yes	Yes	1	9	9
57	R:R:L48	R:R:L95	5.54	Yes	Yes	1	9	8
58	R:R:I98	R:R:L48	4.28	No	Yes	0	8	9
59	R:R:L48	R:R:N284	5.49	Yes	Yes	1	9	9
60	R:R:A51	R:R:S90	3.42	No	No	0	8	6
61	R:R:D52	R:R:S91	5.89	Yes	No	0	9	9
62	R:R:D52	R:R:S281	8.83	Yes	No	0	9	9
63	R:R:D52	R:R:N284	8.08	Yes	Yes	1	9	9
64	R:R:A54	R:R:L87	4.73	No	No	0	6	7
65	R:R:A59	R:R:V55	5.09	No	No	0	6	6
66	R:R:S281	R:R:V55	6.46	No	No	0	9	6
67	R:R:L58	R:R:V57	4.47	No	No	0	5	5
68	R:R:F62	R:R:L58	3.65	No	No	0	5	5
69	R:R:I60	R:R:P61	3.39	Yes	No	0	6	8
70	R:R:H278	R:R:I60	11.93	Yes	Yes	1	6	6
71	R:R:F62	R:R:I80	3.77	No	No	0	5	6
72	R:R:F62	R:R:F83	4.29	No	No	0	5	5
73	R:R:F70	R:R:T65	3.89	Yes	No	0	7	5
74	R:R:I66	R:R:I80	4.42	No	No	0	4	6
75	R:R:F168	R:R:I66	3.77	Yes	No	0	4	4
76	R:R:S67	R:R:Y271	3.82	No	Yes	1	3	3
77	R:R:F70	R:R:T68	3.89	Yes	No	0	7	5
78	R:R:G69	R:R:L167	5.13	No	No	0	4	4
79	R:R:A72	R:R:F70	4.16	No	Yes	0	6	7
80	R:R:C166	R:R:F70	9.78	No	Yes	0	9	7
81	R:R:C159	R:R:C71	7.28	No	No	4	3	2
82	R:R:C71	R:R:Q163	4.58	No	No	0	2	3
83	R:R:C146	R:R:C74	7.28	No	No	0	1	3
84	R:R:C74	R:R:V164	3.42	No	No	0	3	4
85	R:R:C146	R:R:H75	11.79	No	No	0	1	2
86	R:R:C166	R:R:C77	7.28	No	No	0	9	9
87	R:R:C77	R:R:V171	5.12	No	No	0	9	4
88	R:R:L78	R:R:M140	4.24	No	No	0	6	5
89	R:R:L78	R:R:N144	6.87	No	No	0	6	4
90	R:R:L78	R:R:V171	5.96	No	No	0	6	4
91	R:R:F79	R:R:M140	6.22	No	No	0	4	5
92	R:R:C82	R:R:P139	5.65	No	No	0	5	5
93	R:R:C82	R:R:M140	4.86	No	No	0	5	5
94	R:R:F83	R:R:L87	4.87	No	No	0	5	7
95	R:R:F168	R:R:L85	4.87	Yes	Yes	1	4	4
96	R:R:L85	R:R:Y176	3.52	Yes	Yes	1	4	6
97	R:R:L85	R:R:M177	4.24	Yes	Yes	1	4	6
98	R:R:F133	R:R:V86	5.24	No	No	0	3	4
99	R:R:T88	R:R:W246	3.64	No	Yes	1	6	8
100	R:R:Q89	R:R:S132	4.33	Yes	No	0	5	7
101	R:R:I135	R:R:Q89	8.23	No	Yes	1	4	5
102	R:R:G136	R:R:Q89	4.93	No	Yes	0	6	5
103	R:R:N181	R:R:Q89	5.28	Yes	Yes	1	5	5
104	R:R:C185	R:R:Q89	7.63	Yes	Yes	1	5	5
105	R:R:S90	R:R:W129	17.3	No	No	0	6	9
106	R:R:S132	R:R:S90	4.89	No	No	0	7	6
107	R:R:I92	R:R:P189	3.39	No	No	0	7	8
108	R:R:F242	R:R:I92	8.79	Yes	No	1	9	7
109	R:R:I92	R:R:W246	16.44	No	Yes	1	7	8
110	R:R:C185	R:R:F93	4.19	Yes	No	0	5	5
111	R:R:F242	R:R:L95	3.65	Yes	Yes	1	9	8
112	R:R:L95	R:R:N284	9.61	Yes	Yes	1	8	9
113	R:R:L95	R:R:Y288	10.55	Yes	Yes	0	8	9
114	R:R:L96	R:R:P189	4.93	No	No	0	7	8
115	R:R:L192	R:R:L96	4.15	No	No	0	6	7
116	R:R:I98	R:R:R102	6.26	No	No	0	8	9
117	R:R:I98	R:R:Y288	8.46	No	Yes	0	8	9
118	R:R:A99	R:R:Y197	4	No	Yes	0	9	9
119	R:R:D101	R:R:Y112	10.34	No	Yes	2	9	7
120	R:R:R107	R:R:Y103	9.26	No	No	0	6	8
121	R:R:V196	R:R:Y103	10.09	No	No	0	7	8
122	R:R:R199	R:R:Y103	6.17	No	No	0	5	8
123	R:R:A105	R:R:Y112	5.34	No	Yes	0	8	7
124	R:R:I106	R:R:I200	5.89	No	No	0	8	9
125	R:R:I108	R:R:R107	11.27	No	No	0	5	6
126	R:R:I108	R:R:R111	6.26	No	No	0	5	5
127	R:R:N113	R:R:Y112	3.49	No	Yes	0	5	7
128	R:R:V116	R:R:Y112	13.88	No	Yes	0	7	7
129	R:R:R120	R:R:T117	11.64	No	No	0	5	7
130	R:R:G123	R:R:K122	3.49	No	No	0	3	3
131	R:R:F133	R:R:L137	3.65	No	No	0	3	3
132	R:R:F180	R:R:I135	11.3	Yes	No	1	4	4
133	R:R:C185	R:R:I135	4.91	Yes	No	1	5	4
134	R:R:P139	R:R:T138	3.5	No	No	0	5	6
135	R:R:F180	R:R:T138	6.49	Yes	No	0	4	6
136	R:R:P139	R:R:Y176	16.69	No	Yes	0	5	6
137	R:R:P173	R:R:W143	5.4	Yes	Yes	1	4	5
138	R:R:N175	R:R:W143	12.43	No	Yes	1	4	5
139	R:R:W143	R:R:Y176	11.58	Yes	Yes	1	5	6
140	R:R:F180	R:R:W143	4.01	Yes	Yes	1	4	5
141	R:R:C146	R:R:N144	6.3	No	No	0	1	4
142	R:R:N145	R:R:P173	14.66	No	Yes	0	4	4
143	R:R:K150	R:R:K153	7.18	No	Yes	0	3	4
144	R:R:K153	R:R:L167	7.05	Yes	No	3	4	4
145	R:R:D170	R:R:K153	11.06	No	Yes	3	4	4
146	R:R:A154	R:R:C159	3.61	No	No	0	1	3
147	R:R:D170	R:R:L167	10.86	No	No	3	4	4
148	R:R:F168	R:R:V172	13.11	Yes	No	0	4	3
149	R:R:F168	R:R:M177	4.98	Yes	Yes	1	4	6
150	R:R:E169	R:R:M174	4.06	Yes	Yes	1	3	4
151	R:R:E169	R:R:T256	4.23	Yes	No	1	3	4
152	R:R:E169	R:R:H264	13.54	Yes	Yes	1	3	2
153	R:R:E169	R:R:M270	4.06	Yes	No	1	3	4
154	R:R:P173	R:R:V172	3.53	Yes	No	0	4	3
155	R:R:N175	R:R:P173	4.89	No	Yes	1	4	4
156	R:R:M174	R:R:N253	8.41	Yes	No	1	4	5
157	R:R:M174	R:R:T256	4.52	Yes	No	1	4	4
158	R:R:F257	R:R:M174	3.73	Yes	Yes	0	3	4
159	R:R:M177	R:R:Y176	3.59	Yes	Yes	1	6	6
160	R:R:F180	R:R:Y176	5.16	Yes	Yes	1	4	6
161	R:R:N181	R:R:Y176	10.47	Yes	Yes	1	5	6
162	R:R:M177	R:R:N181	8.41	Yes	Yes	1	6	5
163	R:R:C254	R:R:V178	3.42	No	No	0	6	5
164	R:R:F257	R:R:V178	9.18	Yes	No	0	3	5
165	R:R:F257	R:R:Y179	7.22	Yes	No	0	3	5
166	R:R:C185	R:R:N181	6.3	Yes	Yes	1	5	5
167	R:R:H250	R:R:N181	3.83	Yes	Yes	1	6	5
168	R:R:F182	R:R:V186	6.55	No	No	1	5	7
169	R:R:F182	R:R:L187	4.87	No	No	0	5	4
170	R:R:F182	R:R:H250	12.44	No	Yes	1	5	6
171	R:R:F183	R:R:V188	3.93	No	No	0	4	5
172	R:R:H250	R:R:V186	6.92	Yes	No	1	6	7
173	R:R:P189	R:R:V188	3.53	No	No	0	8	5
174	R:R:F242	R:R:L190	3.65	Yes	No	1	9	6
175	R:R:L190	R:R:L247	4.15	No	No	1	6	6
176	R:R:M193	R:R:Y197	3.59	No	Yes	0	8	9
177	R:R:F242	R:R:M193	8.71	Yes	No	0	9	8
178	R:R:L235	R:R:Y197	7.03	Yes	Yes	0	8	9
179	R:R:I238	R:R:Y197	9.67	No	Yes	0	8	9
180	R:R:V239	R:R:Y197	3.79	No	Yes	0	8	9
181	R:R:L198	R:R:L202	4.15	No	No	0	4	4
182	R:R:F201	R:R:R205	6.41	Yes	No	0	5	5
183	R:R:A232	R:R:F201	4.16	No	Yes	0	7	5
184	R:R:E228	R:R:R205	16.28	No	No	0	7	5
185	R:R:Q207	R:R:R206	10.51	No	No	0	6	4
186	R:R:Q226	R:R:T224	7.09	No	No	0	4	5
187	R:R:E228	R:R:L225	15.9	No	No	0	7	4
188	R:R:H230	R:R:S234	4.18	No	No	0	8	8
189	R:R:I237	R:R:K233	5.82	No	No	0	6	7
190	R:R:I238	R:R:Y288	3.63	No	Yes	0	8	9
191	R:R:F242	R:R:W246	9.02	Yes	Yes	1	9	8
192	R:R:C245	R:R:N280	6.3	No	No	0	8	9
193	R:R:S277	R:R:W246	6.18	No	Yes	1	7	8
194	R:R:N280	R:R:W246	11.3	No	Yes	0	9	8
195	R:R:L249	R:R:N253	4.12	No	No	1	5	5
196	R:R:F255	R:R:I251	3.77	No	No	0	4	5
197	R:R:I252	R:R:L269	4.28	No	No	0	5	4
198	R:R:H264	R:R:T256	9.58	Yes	No	1	2	4
199	R:R:F257	R:R:F258	9.65	Yes	No	0	3	6
200	R:R:C259	R:R:D261	4.67	No	No	0	4	1
201	R:R:C259	R:R:C262	7.28	No	No	0	4	1
202	R:R:H264	R:R:M270	3.94	Yes	No	1	2	4
203	R:R:P266	R:R:W268	12.16	No	No	5	3	1
204	R:R:L269	R:R:P266	4.93	No	No	5	4	3
205	R:R:L267	R:R:Y271	8.21	No	Yes	0	3	3
206	R:R:L269	R:R:W268	11.39	No	No	5	4	1
207	R:R:H278	R:R:I274	3.98	Yes	No	1	6	4
208	R:R:H278	R:R:S277	6.97	Yes	No	1	6	7
209	R:R:N280	R:R:N284	12.26	No	Yes	0	9	9
210	R:R:F286	R:R:Y290	4.13	No	No	0	6	6
211	R:R:I287	R:R:Y288	6.04	No	Yes	0	8	9
212	R:R:A289	R:R:F295	5.55	No	Yes	0	7	8
213	R:R:R296	R:R:Y290	6.17	No	No	0	8	6
214	R:R:F295	R:R:I292	6.28	Yes	No	0	8	8
215	R:R:Q297	R:R:R293	4.67	No	No	0	4	4
216	R:R:F295	R:R:F299	6.43	Yes	No	0	8	6
217	R:R:R300	R:R:R304	7.46	No	No	0	5	5
218	R:R:A30	R:R:T298	3.36	No	No	0	8	7
219	R:R:G147	R:R:Q148	3.29	No	No	0	3	3
220	R:R:V12	R:R:V275	3.21	No	No	0	5	5
221	R:R:A165	R:R:K153	3.21	No	Yes	0	3	4
222	R:R:A243	R:R:L190	3.15	No	No	1	5	6
223	R:R:A243	R:R:L247	3.15	No	No	1	5	6
224	R:R:A273	R:R:L249	3.15	No	No	0	6	5
225	R:R:I16	R:R:V282	3.07	No	No	0	7	7
226	R:R:I53	R:R:V25	3.07	No	No	0	7	4
227	R:R:I104	R:R:V116	3.07	No	No	0	5	7
228	R:R:I16	R:R:T279	3.04	No	No	0	7	5
229	R:R:I302	R:R:T298	3.04	No	No	0	6	7
230	R:R:A154	R:R:E151	3.02	No	No	0	1	2
231	R:R:L22	R:R:V18	2.98	No	No	0	5	4
232	R:R:L194	R:R:V239	2.98	No	No	0	4	8
233	R:R:L241	R:R:V283	2.98	Yes	No	0	7	6
234	R:R:I16	R:R:I60	2.94	No	Yes	0	7	6
235	R:R:A63	R:R:H278	2.93	No	Yes	0	5	6
236	R:R:A265	R:R:H264	2.93	No	Yes	0	4	2
237	R:R:N39	R:R:T41	2.92	No	Yes	2	7	8
238	R:R:N42	R:R:T41	2.92	Yes	Yes	2	8	8
239	R:R:Q157	R:R:S156	2.89	Yes	No	0	3	4
240	R:R:I302	R:R:L33	2.85	No	No	0	6	5
241	R:R:I100	R:R:L96	2.85	No	No	0	6	7
242	R:R:I127	R:R:L131	2.85	No	No	0	3	4
243	R:R:I200	R:R:L235	2.85	No	Yes	0	9	8
244	R:R:I237	R:R:L241	2.85	No	Yes	0	6	7
245	R:R:I287	R:R:L241	2.85	No	Yes	0	8	7
246	R:R:I251	R:R:L247	2.85	No	No	0	5	6
247	R:R:C128	R:R:F93	2.79	No	No	0	7	5
248	R:R:A97	R:R:F44	2.77	No	Yes	0	7	7
249	R:R:A81	R:R:F168	2.77	No	Yes	0	5	4
250	R:R:A184	R:R:F180	2.77	No	Yes	0	3	4
251	R:R:L187	R:R:L191	2.77	No	No	0	4	3
252	R:R:A231	R:R:F201	2.77	No	Yes	0	8	5
253	R:R:S6	R:R:Y271	2.54	No	Yes	0	4	3
254	R:R:F93	R:R:L131	2.44	No	No	0	5	4
255	R:R:F201	R:R:L202	2.44	Yes	No	0	5	4
256	R:R:F299	R:R:Y290	2.06	No	No	0	6	6
257	R:R:G147	R:R:P149	2.03	No	No	0	3	5
258	R:R:F133	R:R:W129	2	No	No	0	3	9
259	R:R:A20	R:R:G56	1.95	No	No	0	7	7
260	R:R:A121	R:R:G118	1.95	No	Yes	0	7	1
261	R:R:C259	R:R:P260	1.88	No	No	0	4	1
262	R:R:A273	R:R:P248	1.87	No	No	0	6	9
263	R:R:A265	R:R:P266	1.87	No	No	0	4	3
264	R:R:G69	R:R:T68	1.82	No	No	0	4	5
265	R:R:G118	R:R:T117	1.82	Yes	No	0	1	7
266	R:R:A49	R:R:C28	1.81	No	No	0	9	7
267	R:R:P149	R:R:V164	1.77	No	No	0	5	4
268	R:R:G23	R:R:L22	1.71	No	No	0	9	5
269	R:R:G23	R:R:L26	1.71	No	No	0	9	6
270	R:R:G195	R:R:L194	1.71	No	No	0	4	4
271	R:R:A99	R:R:V196	1.7	No	No	0	9	7
272	R:R:G142	R:R:N144	1.7	No	No	0	4	4
273	R:R:G160	R:R:Q163	1.64	No	No	0	1	3
274	R:R:L276	R:R:P248	1.64	No	No	0	7	9
275	R:R:S6	R:R:V8	1.62	No	No	0	4	5
276	R:R:A203	R:R:I106	1.62	No	No	0	6	8
277	R:R:A126	R:R:K122	1.61	No	No	0	4	3
278	R:R:A231	R:R:K227	1.61	No	No	0	8	6
279	R:R:V27	R:R:V45	1.6	No	No	0	9	8
280	R:R:T11	R:R:V12	1.59	No	No	0	4	5
281	R:R:T117	R:R:T119	1.57	No	No	0	7	5
282	R:R:C71	R:R:Q157	1.53	No	Yes	4	2	3
283	R:R:C159	R:R:Q157	1.53	No	Yes	4	3	3
284	R:R:A165	R:R:Q157	1.52	No	Yes	0	3	3
285	R:R:F79	R:R:G76	1.51	No	No	0	4	6
286	R:R:L235	R:R:S234	1.5	Yes	No	0	8	8
287	R:R:L19	R:R:V282	1.49	No	No	0	5	7
288	R:R:N36	R:R:S35	1.49	No	No	0	5	5
289	R:R:L115	R:R:V116	1.49	No	No	0	4	7
290	R:R:G118	R:R:Y43	1.45	Yes	No	0	1	5
291	R:R:E228	R:R:V229	1.43	No	No	0	7	5
292	R:R:L241	R:R:L244	1.38	Yes	No	0	7	5
293	R:R:L244	R:R:L276	1.38	No	No	0	5	7
294	R:R:E151	R:R:H155	1.23	No	No	0	2	3
295	R:R:F201	R:R:L235	1.22	Yes	Yes	0	5	8
296	R:R:Q297	R:R:R300	1.17	No	No	0	4	5
297	R:R:L33	R:R:W32	1.14	No	No	0	5	3
298	R:R:R291	R:R:R296	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?2	10.0823	13	1	0
2	R:R:Y9	14.815	4	1	5
3	R:R:E13	8.472	5	1	6
4	R:R:N24	8.5225	4	0	9
5	R:R:N34	7.6	4	2	6
6	R:R:L37	6.872	5	2	8
7	R:R:T41	4.465	4	2	8
8	R:R:N42	4.33	4	2	8
9	R:R:F44	5.294	5	0	7
10	R:R:L48	5.185	4	1	9
11	R:R:D52	8.07	5	1	9
12	R:R:I60	5.992	5	1	6
13	R:R:F70	5.43	4	0	7
14	R:R:L85	4.5975	4	1	4
15	R:R:Q89	6.08	5	1	5
16	R:R:L95	7.3375	4	1	8
17	R:R:Y112	7.858	5	2	7
18	R:R:G118	2.225	4	0	1
19	R:R:W143	8.355	4	1	5
20	R:R:K153	7.125	4	3	4
21	R:R:Q157	1.8675	4	4	3
22	R:R:F168	10.6933	6	1	4
23	R:R:E169	6.282	5	1	3
24	R:R:P173	7.12	4	1	4
25	R:R:M174	5.18	4	1	4
26	R:R:Y176	8.50167	6	1	6
27	R:R:M177	5.305	4	1	6
28	R:R:F180	5.946	5	1	4
29	R:R:N181	6.50833	6	1	5
30	R:R:C185	5.7575	4	1	5
31	R:R:Y197	5.616	5	0	9
32	R:R:F201	3.4	5	0	5
33	R:R:L235	3.15	4	0	8
34	R:R:L241	2.515	4	0	7
35	R:R:F242	6.764	5	1	9
36	R:R:W246	9.74	6	1	8
37	R:R:H250	7.36	4	1	6
38	R:R:F257	7.445	4	0	3
39	R:R:H264	7.4975	4	1	2
40	R:R:Y271	11.3375	4	1	3
41	R:R:H278	7.99	6	1	6
42	R:R:N284	8.86	4	1	9
43	R:R:Y288	7.17	4	0	9
44	R:R:F295	7.054	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:H278	19.7564	9.82	Yes	Yes	1	0	6
2	R:R:E13	R:R:H278	12.5633	12.31	Yes	Yes	1	6	6
3	R:R:H278	R:R:I60	12.4867	11.93	Yes	Yes	1	6	6
4	L:L:?2	R:R:F168	14.7736	34.66	Yes	Yes	1	0	4
5	R:R:F168	R:R:I66	14.6544	3.77	Yes	No	0	4	4
6	R:R:I66	R:R:I80	13.4918	4.42	No	No	0	4	6
7	R:R:F62	R:R:I80	12.2993	3.77	No	No	0	5	6
8	L:L:?2	R:R:W246	94.668	11.86	Yes	Yes	1	0	8
9	R:R:N280	R:R:W246	60.4105	11.3	No	Yes	0	9	8
10	R:R:N280	R:R:N284	58.9966	12.26	No	Yes	0	9	9
11	R:R:D52	R:R:N284	76.4661	8.08	Yes	Yes	1	9	9
12	R:R:D52	R:R:N24	100	12.12	Yes	Yes	0	9	9
13	R:R:A49	R:R:N24	93.9355	4.69	No	Yes	0	9	9
14	R:R:A49	R:R:V27	90.8522	3.39	No	No	0	9	9
15	R:R:A289	R:R:V27	87.7007	3.39	No	No	0	7	9
16	R:R:A289	R:R:F295	86.2868	5.55	No	Yes	0	7	8
17	R:R:F295	R:R:F299	17.5589	6.43	Yes	No	0	8	6
18	R:R:F295	R:R:L37	27.4605	12.18	Yes	Yes	2	8	8
19	R:R:L37	R:R:N34	17.4737	9.61	Yes	Yes	2	8	6
20	R:R:N34	R:R:T298	11.7499	8.77	Yes	No	0	6	7
21	R:R:F295	R:R:N42	40.9352	4.83	Yes	Yes	2	8	8
22	R:R:N42	R:R:T41	38.9677	2.92	Yes	Yes	2	8	8
23	R:R:D101	R:R:T41	26.0508	5.78	No	Yes	2	9	8
24	R:R:D101	R:R:F44	24.7647	10.75	No	Yes	0	9	7
25	R:R:A121	R:R:F44	13.5258	4.16	No	Yes	0	7	7
26	R:R:A121	R:R:G118	11.801	1.95	No	Yes	0	7	1
27	R:R:T41	R:R:Y112	11.1793	6.24	Yes	Yes	2	8	7
28	R:R:F242	R:R:W246	40.1346	9.02	Yes	Yes	1	9	8
29	R:R:F242	R:R:L95	33.4355	3.65	Yes	Yes	1	9	8
30	R:R:L48	R:R:L95	23.568	5.54	Yes	Yes	1	9	8
31	R:R:I98	R:R:L48	13.5343	4.28	No	Yes	0	8	9
32	R:R:L95	R:R:Y288	27.2518	10.55	Yes	Yes	0	8	9
33	R:R:I98	R:R:Y288	11.6179	8.46	No	Yes	0	8	9
34	L:L:?2	R:R:N181	49.1035	4.76	Yes	Yes	1	0	5
35	R:R:N181	R:R:Q89	10.9791	5.28	Yes	Yes	1	5	5
36	L:L:?2	R:R:L85	35.4329	5.76	Yes	Yes	1	0	4
37	R:R:L85	R:R:Y176	36.7105	3.52	Yes	Yes	1	4	6
38	R:R:P139	R:R:Y176	68.0465	16.69	No	Yes	0	5	6
39	R:R:C82	R:R:P139	65.2826	5.65	No	No	0	5	5
40	R:R:C82	R:R:M140	63.6004	4.86	No	No	0	5	5
41	R:R:L78	R:R:M140	58.5026	4.24	No	No	0	6	5
42	R:R:L78	R:R:V171	40.948	5.96	No	No	0	6	4
43	R:R:C77	R:R:V171	39.351	5.12	No	No	0	9	4
44	R:R:C166	R:R:C77	37.5367	7.28	No	No	0	9	9
45	R:R:C166	R:R:F70	35.9354	9.78	No	Yes	0	9	7
46	R:R:N181	R:R:Y176	37.7497	10.47	Yes	Yes	1	5	6
47	R:R:F70	R:R:T68	30.6503	3.89	Yes	No	0	7	5
48	R:R:G69	R:R:T68	28.7978	1.82	No	No	0	4	5
49	R:R:G69	R:R:L167	26.9367	5.13	No	No	0	4	4
50	R:R:K153	R:R:L167	23.1464	7.05	Yes	No	3	4	4
51	R:R:A165	R:R:K153	19.4157	3.21	No	Yes	0	3	4
52	R:R:A165	R:R:Q157	17.512	1.52	No	Yes	0	3	3
53	R:R:L78	R:R:N144	17.5078	6.87	No	No	0	6	4
54	R:R:C146	R:R:N144	13.6791	6.3	No	No	0	1	4
55	R:R:I92	R:R:P189	11.1707	3.39	No	No	0	7	8
56	R:R:F242	R:R:M193	41.3185	8.71	Yes	No	0	9	8
57	R:R:M193	R:R:Y197	39.96	3.59	No	Yes	0	8	9
58	R:R:A99	R:R:Y197	16.771	4	No	Yes	0	9	9
59	R:R:A99	R:R:V196	14.4117	1.7	No	No	0	9	7
60	R:R:V196	R:R:Y103	11.9969	10.09	No	No	0	7	8
61	R:R:L235	R:R:Y197	37.311	7.03	Yes	Yes	0	8	9
62	L:L:?2	R:R:E169	17.7165	5.52	Yes	Yes	1	0	3
63	R:R:F257	R:R:M174	12.4313	3.73	Yes	Yes	0	3	4
64	R:R:I238	R:R:Y288	24.7434	3.63	No	Yes	0	8	9
65	R:R:I238	R:R:Y197	24.0492	9.67	No	Yes	0	8	9
66	R:R:F201	R:R:L235	23.3976	1.22	Yes	Yes	0	5	8
67	R:R:I287	R:R:Y288	11.0643	6.04	No	Yes	0	8	9
68	R:R:D52	R:R:L48	30.9186	5.43	Yes	Yes	1	9	9
69	R:R:L95	R:R:N284	21.0596	9.61	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?2	R:R:V84	5.17	1	Yes	No	0	6	0	1
L:L:?2	R:R:L85	5.76	1	Yes	Yes	0	4	0	1
L:L:?2	R:R:T88	10.23	1	Yes	No	0	6	0	1
L:L:?2	R:R:F168	34.66	1	Yes	Yes	0	4	0	1
L:L:?2	R:R:E169	5.52	1	Yes	Yes	0	3	0	1
L:L:?2	R:R:N181	4.76	1	Yes	Yes	0	5	0	1
L:L:?2	R:R:W246	11.86	1	Yes	Yes	0	8	0	1
L:L:?2	R:R:L249	15.37	1	Yes	No	0	5	0	1
L:L:?2	R:R:H250	6.25	1	Yes	Yes	0	6	0	1
L:L:?2	R:R:N253	9.53	1	Yes	No	0	5	0	1
L:L:?2	R:R:I274	6.93	1	Yes	No	0	4	0	1
L:L:?2	R:R:S277	5.21	1	Yes	No	0	7	0	1
L:L:?2	R:R:H278	9.82	1	Yes	Yes	0	6	0	1
R:R:E13	R:R:Y9	13.47	1	Yes	Yes	6	5	2	2
R:R:I274	R:R:Y9	4.84	1	No	Yes	4	5	1	2
R:R:E13	R:R:I60	6.83	1	Yes	Yes	6	6	2	2
R:R:E13	R:R:H278	12.31	1	Yes	Yes	6	6	2	1
R:R:H278	R:R:I60	11.93	1	Yes	Yes	6	6	1	2
R:R:F168	R:R:I66	3.77	1	Yes	No	4	4	1	2
R:R:F168	R:R:L85	4.87	1	Yes	Yes	4	4	1	1
R:R:L85	R:R:Y176	3.52	1	Yes	Yes	4	6	1	2
R:R:L85	R:R:M177	4.24	1	Yes	Yes	4	6	1	2
R:R:T88	R:R:W246	3.64	1	No	Yes	6	8	1	1
R:R:N181	R:R:Q89	5.28	1	Yes	Yes	5	5	1	2
R:R:C185	R:R:Q89	7.63	1	Yes	Yes	5	5	2	2
R:R:F242	R:R:I92	8.79	1	Yes	No	9	7	2	2
R:R:I92	R:R:W246	16.44	1	No	Yes	7	8	2	1
R:R:F168	R:R:V172	13.11	1	Yes	No	4	3	1	2
R:R:F168	R:R:M177	4.98	1	Yes	Yes	4	6	1	2
R:R:E169	R:R:M174	4.06	1	Yes	Yes	3	4	1	2
R:R:E169	R:R:T256	4.23	1	Yes	No	3	4	1	2
R:R:E169	R:R:H264	13.54	1	Yes	Yes	3	2	1	2
R:R:E169	R:R:M270	4.06	1	Yes	No	3	4	1	2
R:R:M174	R:R:N253	8.41	1	Yes	No	4	5	2	1
R:R:M174	R:R:T256	4.52	1	Yes	No	4	4	2	2
R:R:M177	R:R:Y176	3.59	1	Yes	Yes	6	6	2	2
R:R:N181	R:R:Y176	10.47	1	Yes	Yes	5	6	1	2
R:R:M177	R:R:N181	8.41	1	Yes	Yes	6	5	2	1
R:R:C185	R:R:N181	6.3	1	Yes	Yes	5	5	2	1
R:R:H250	R:R:N181	3.83	1	Yes	Yes	6	5	1	1
R:R:F182	R:R:V186	6.55	1	No	No	5	7	2	2
R:R:F182	R:R:H250	12.44	1	No	Yes	5	6	2	1
R:R:H250	R:R:V186	6.92	1	Yes	No	6	7	1	2
R:R:F242	R:R:W246	9.02	1	Yes	Yes	9	8	2	1
R:R:S277	R:R:W246	6.18	1	No	Yes	7	8	1	1
R:R:N280	R:R:W246	11.3	0	No	Yes	9	8	2	1
R:R:L249	R:R:N253	4.12	1	No	No	5	5	1	1
R:R:H264	R:R:T256	9.58	1	Yes	No	2	4	2	2
R:R:H264	R:R:M270	3.94	1	Yes	No	2	4	2	2
R:R:H278	R:R:I274	3.98	1	Yes	No	6	4	1	1
R:R:H278	R:R:S277	6.97	1	Yes	No	6	7	1	1
R:R:A273	R:R:L249	3.15	0	No	No	6	5	2	1
R:R:A63	R:R:H278	2.93	0	No	Yes	5	6	2	1
R:R:A81	R:R:F168	2.77	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	5G53_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	262
Number of Links	298
Number of Hubs	44
Number of Links mediated by Hubs	161
Number of Communities	5
Number of Nodes involved in Communities	61
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	54190
Length Of Smallest Path	3
Average Path Length	14.2472
Length of Longest Path	38
Minimum Path Strength	1.36
Average Path Strength	6.87106
Maximum Path Strength	25.015
Minimum Path Correlation	0.7
Average Path Correlation	0.920781
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.3393
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.2581
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled adenosine receptor activity • protein-containing complex binding • binding • protein binding • calmodulin binding • identical protein binding • cytoskeletal protein binding • alpha-actinin binding • actinin binding • lipid binding • type 5 metabotropic glutamate receptor binding • signaling receptor binding • glutamate receptor binding • G protein-coupled receptor binding • G protein-coupled glutamate receptor binding • enzyme binding • response to stimulus • response to chemical • response to xenobiotic stimulus • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • biological regulation • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of cellular process • regulation of alpha-beta T cell activation • regulation of leukocyte activation • negative regulation of biological process • regulation of cell activation • lymphocyte activation • negative regulation of lymphocyte activation • leukocyte cell-cell adhesion • negative regulation of cell adhesion • leukocyte activation • cell adhesion • cell-cell adhesion • T cell activation • negative regulation of cellular process • alpha-beta T cell activation • regulation of immune system process • regulation of multicellular organismal process • regulation of cell-cell adhesion • regulation of biological process • regulation of cell adhesion • cell activation • regulation of T cell activation • negative regulation of cell activation • negative regulation of T cell activation • negative regulation of immune system process • negative regulation of leukocyte cell-cell adhesion • immune system process • negative regulation of cell-cell adhesion • regulation of leukocyte cell-cell adhesion • cellular process • negative regulation of alpha-beta T cell activation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • regulation of lymphocyte activation • developmental process • multicellular organism development • central nervous system development • anatomical structure development • nervous system development • system development • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • signaling • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • cell communication • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • regulation of programmed cell death • positive regulation of apoptotic signaling pathway • positive regulation of response to stimulus • signal transduction • positive regulation of cellular process • positive regulation of programmed cell death • regulation of apoptotic process • cell death • positive regulation of apoptotic process • apoptotic signaling pathway • regulation of response to stimulus • apoptotic process • programmed cell death • positive regulation of signaling • regulation of apoptotic signaling pathway • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • import into cell • phagocytosis • endocytosis • vesicle-mediated transport • response to nitrogen compound • response to purine-containing compound • response to caffeine • response to alkaloid • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • system process • sensory perception • nervous system process • negative regulation of vascular permeability • regulation of vascular permeability • circulatory system process • vascular process in circulatory system • blood circulation • startle response • regulation of response to external stimulus • neuromuscular process • negative regulation of response to stimulus • prepulse inhibition • response to external stimulus • negative regulation of response to external stimulus • nitrogen compound transport • positive regulation of neurotransmitter secretion • positive regulation of amine transport • acetylcholine secretion, neurotransmission • establishment of localization in cell • positive regulation of acetylcholine secretion, neurotransmission • positive regulation of neurotransmitter transport • positive regulation of synaptic transmission, cholinergic • neurotransmitter secretion • positive regulation of synaptic transmission • regulation of acetylcholine secretion, neurotransmission • neurotransmitter transport • organic cation transport • acetate ester transport • regulation of secretion • signal release from synapse • acetylcholine transport • cellular localization • positive regulation of secretion by cell • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • acetylcholine secretion • secretion • regulation of neurotransmitter transport • export from cell • amine transport • positive regulation of transport • regulation of neurotransmitter secretion • synaptic transmission, cholinergic • regulation of amine transport • regulation of synaptic transmission, cholinergic • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • defense response • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • synaptic transmission, dopaminergic • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • inhibitory postsynaptic potential • regulation of membrane potential • cellular defense response • behavior • locomotory behavior • intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • long-term synaptic potentiation • positive regulation of long-term synaptic potentiation • regulation of synaptic plasticity • regulation of long-term synaptic potentiation • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • positive regulation of synaptic transmission, glutamatergic • regulation of mitochondrial membrane potential • positive regulation of synaptic transmission, GABAergic • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • regulation of defense response • negative regulation of inflammatory response • regulation of inflammatory response • regulation of response to stress • negative regulation of defense response • renal system process • positive regulation of urine volume • regulation of urine volume • eating behavior • feeding behavior • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • circadian behavior • positive regulation of behavior • positive regulation of circadian rhythm • positive regulation of multicellular organismal process • sleep • positive regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • catecholamine transport • norepinephrine transport • catecholamine secretion • norepinephrine secretion • regulation of norepinephrine secretion • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • negative regulation of apoptotic process • regulation of neuron apoptotic process • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • generation of neurons • anatomical structure morphogenesis • neuron development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of tube diameter • regulation of tube size • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • excitatory postsynaptic potential • establishment of protein localization • regulation of protein localization • positive regulation of establishment of protein localization • protein localization to extracellular region • positive regulation of protein transport • intracellular protein localization • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • positive regulation of protein secretion • regulation of protein secretion • protein transport • macromolecule localization • positive regulation of protein localization • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • response to amine • response to amphetamine • membrane depolarization • regulation of glutamate secretion • regulation of amino acid transport • glutamate secretion • organic anion transport • carboxylic acid transport • positive regulation of glutamate secretion • positive regulation of organic acid transport • organic acid transport • amino acid transport • acidic amino acid transport • positive regulation of amino acid transport • regulation of organic acid transport • dicarboxylic acid transport • postsynapse • postsynaptic membrane • synapse • cell junction • plasma membrane region • synaptic membrane • presynapse • presynaptic active zone • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • glutamatergic synapse • axon • cell leading edge • axolemma • leading edge membrane • neuron projection membrane • main axon • cell projection membrane • cell body • neuronal cell body • polymeric cytoskeletal fiber • intracellular membraneless organelle • intermediate filament cytoskeleton • cytoskeleton • membraneless organelle • intermediate filament • supramolecular fiber • supramolecular polymer • supramolecular complex • neuron to neuron synapse • asymmetric synapse
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NEC
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	NEC
Name	N-Ethyl-5'-Carboxamido Adenosine
Synonyms	N-Ethyl-5'-Carboxamido Adenosine
Identifier
Formula	C12 H16 N6 O4
Molecular Weight	308.293
SMILES
PubChem	448222
Formal Charge	0
Total Atoms	38
Total Chiral Atoms	4
Total Bonds	40
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P29274
Sequence	>5G53_nogp_Chain_R S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N S N L Q N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G F C A A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I P L R Y N G L V T G T R A K G I I A I C W V L S F A I G L T P M L G W N N C G Q P K E G K A H S Q G C G E G Q V A C L F E D V V P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P D C S H A P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R Q T F R K I I R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ZDR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	HMS1413f12	Na	-	1.92	2020-09-16	doi.org/10.1002/anie.202003788
	6ZDV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Chromone 5d	Na	-	2.13	2020-09-16	doi.org/10.1002/anie.202003788
	8JWZ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	AB928	Na	-	2.37	2023-08-16	doi.org/10.1007/s11427-023-2459-8
	5MZJ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	Na	-	2	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	5MZP	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Caffeine	Na	-	2.1	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	5N2R	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-36	Na	-	2.8	2017-07-26	doi.org/10.1016/j.str.2017.06.012
	7ARO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUF5833	Na	-	3.12	2021-04-07	doi.org/10.1021/acs.jmedchem.0c01856
	8CU7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LJ-4517	Na	-	2.05	2022-08-31	doi.org/10.1021/acs.jmedchem.2c00462
	5IU4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.72	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IU7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456346	Na	-	1.9	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IU8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456347	Na	-	2	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IUA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456348	Na	-	2.2	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5IUB	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Q27456344	Na	-	2.1	2016-06-29	doi.org/10.1021/acs.jmedchem.6b00653
	5VRA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.35	2017-12-13	doi.org/10.1038/nprot.2017.135
	5NLX	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.14	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5NM2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.95	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	8FYN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2023-03-08	doi.org/10.1038/s41467-023-36733-4
	8RW0	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	Na	-	1.94	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	5OLG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.87	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Vipadenant	Na	-	2.6	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Tozadenant	Na	-	3.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUAA41063	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OLZ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	1.9	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OM1	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	6LPJ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	6LPK	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	6LPL	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2020-11-25	doi.org/10.1038/s41598-020-76277-x
	8CIC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Etrumadenant	Na	-	2.1	2023-05-31	doi.org/10.1038/s42004-023-00894-6
	7RM5	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.79	2021-09-08	doi.org/10.1073/pnas.2106041118
	6JZH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.25	2019-10-30	doi.org/10.1107/S1600576719012846
	8A2O	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	Na	-	3.45	2023-08-30	doi.org/10.1107/S1600576723006428
	8A2P	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUAA47070	Na	-	3.5	2023-08-30	doi.org/10.1107/S1600576723006428
	6PS7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.85	2019-11-13	doi.org/10.1107/S2052252519013137
	6WQA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2	2020-11-18	doi.org/10.1107/S2052252520012701
	8GNE	A	Nucleotide	Adenosine	A_2A	Homo sapiens	KW-6356	Na	-	2.3	2023-03-22	doi.org/10.1124/molpharm.122.000633
	5K2A	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.5	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2B	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.5	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2C	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.9	2016-09-21	doi.org/10.1126/sciadv.1600292
	5K2D	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.9	2016-09-21	doi.org/10.1126/sciadv.1600292
	4EIY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.8	2012-07-25	doi.org/10.1126/science.1219218
	6GT3	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Imaradenant	Na	-	2	2019-06-26	doi.org/10.1136/jitc-2019-000417
	8RQQ	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	2.37	2024-04-03	doi.org/10.1021/acs.cgd.4c00087
	8RVW	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	2.65	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RW4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	AzoSwitch2	Na	-	2.2	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RW7	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch1	Na	-	2.25	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.31	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWD	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	2.05	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWE	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch4	Na	-	2.2	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.45	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWI	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch2	Na	-	2.8	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	8RWX	A	Nucleotide	Adenosine	A_2A	Homo sapiens	StilSwitch3	Na	-	3.05	2025-01-08	doi.org/10.1038/s41467-024-55109-w
	9FUP	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	Na	-	2.5	2025-01-22	doi.org/10.1038/s42004-024-01404-y
	9H2X	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR1	Na	-	1.75	2025-06-18	To be published
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR0	Na	-	1.71	2025-06-18	To be published
	3VG9	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Antibody	-	2.7	2012-02-01	doi.org/10.1038/nature10750
	3VGA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Antibody	-	3.1	2012-02-01	doi.org/10.1038/nature10750
	7PX4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-2113	-	-	2.25	2022-03-02	doi.org/10.1002/anie.202115545
	7PYR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PSB-2115	-	-	2.6	2022-03-02	doi.org/10.1002/anie.202115545
	8JWY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	2-118	-	-	2.33	2023-08-16	doi.org/10.1007/s11427-023-2459-8
	6AQF	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.51	2018-01-10	doi.org/10.1016/j.cell.2017.12.004
	8DU3	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 105526064	-	-	2.5	2022-08-10	doi.org/10.1016/j.ejmech.2022.114620
	3PWH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.3	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	3REY	A	Nucleotide	Adenosine	A_2A	Homo sapiens	XAC	-	-	3.31	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	3RFM	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Caffeine	-	-	3.6	2011-09-07	doi.org/10.1016/j.str.2011.06.014
	5WF5	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.6	2018-02-21	doi.org/10.1016/j.str.2017.12.013
	5WF6	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.9	2018-02-21	doi.org/10.1016/j.str.2017.12.013
	8CU6	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LJ-4517	-	-	2.8	2022-08-31	doi.org/10.1021/acs.jmedchem.2c00462
	3UZA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	GTPL9236	-	-	3.27	2012-03-21	doi.org/10.1021/jm201376w
	3UZC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	-	-	3.34	2012-03-21	doi.org/10.1021/jm201376w
	2YDO	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	-	3	2011-05-18	doi.org/10.1038/nature10136
	2YDV	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	-	2.6	2011-05-18	doi.org/10.1038/nature10136
	5G53	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	Gs	3.4	2016-08-03	doi.org/10.1038/nature18966
	5G53 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-		3.4	2016-08-03	doi.org/10.1038/nature18966
	7T32	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.4	2022-08-10	doi.org/10.1038/s41467-022-32125-2
	8C9W	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Etrumadenant	-	-	2.11	2023-07-12	doi.org/10.1038/s42004-023-00894-6
	8PWN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Theophylline	-	-	2.75	2023-10-25	doi.org/10.1038/s42004-023-01014-0
	5UIG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Cmpd-1	-	-	3.5	2017-02-08	doi.org/10.1073/pnas.1621423114
	5UVI	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	3.2	2017-05-24	doi.org/10.1107/S205225251700570X
	6MH8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	4.2	2019-04-24	doi.org/10.1107/S205225251900263X
	6S0L	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.65	2020-07-15	doi.org/10.1107/S2052252520011379
	6S0Q	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.65	2020-07-15	doi.org/10.1107/S2052252520011379
	7EZC	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UKA	-	-	3.8	2022-04-13	doi.org/10.1107/S2052252522001907
	4UG2	A	Nucleotide	Adenosine	A_2A	Homo sapiens	CGS21680	-	-	2.6	2015-04-08	doi.org/10.1124/mol.114.097360
	4UHR	A	Nucleotide	Adenosine	A_2A	Homo sapiens	CGS21680	-	-	2.6	2015-04-08	doi.org/10.1124/mol.114.097360
	8GNG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Istradefylline	-	-	3.2	2023-03-22	doi.org/10.1124/molpharm.122.000633
	5JTB	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.8	2017-05-31	doi.org/10.1126/sciadv.1602952
	3EML	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	-	-	2.6	2008-10-14	doi.org/10.1126/science.1164772
	3QAK	A	Nucleotide	Adenosine	A_2A	Homo sapiens	UK-432097	-	-	2.71	2011-03-09	doi.org/10.1126/science.1202793
	6GDG	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-	Gs/β1/γ1	4.11	2018-05-16	doi.org/10.7554/eLife.35946
	6GDG (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	NECA	-		4.11	2018-05-16	doi.org/10.7554/eLife.35946
	8WDT	A	Nucleotide	Adenosine	A_2A	Homo sapiens	photoNECA	-	-	3.34	2024-01-17	doi.org/10.1016/j.bbrc.2023.149393
	8RLN	A	Nucleotide	Adenosine	A_2A	Homo sapiens	LUF5834	-	-	2.43	2024-06-19	doi.org/10.1021/acsptsci.4c00051
	9EE8	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	2.63	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE8 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		2.63	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE9	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	3.16	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EE9 (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		3.16	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EEA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-	Gs/β1/γ2	3.36	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	9EEA (No Gprot)	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Adenosine	-		3.36	2025-04-09	doi.org/10.1038/s41467-025-56434-4
	8UGW	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 3086599	-	-	3.9	2024-12-18	doi.org/10.1038/s41557-024-01719-2

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