Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:E13 9.096536
2R:R:N24 6.6775409
3R:R:N34 9.6325426
4R:R:L37 6.46333628
5R:R:N42 7.015428
6R:R:F44 5.22407
7R:R:V55 5.21406
8R:R:I60 4.46571736
9R:R:F70 4.73407
10R:R:L78 4.6575446
11R:R:F83 6.2975445
12R:R:L85 4.4775414
13R:R:Q89 6.316565
14R:R:I92 4.97407
15R:R:F93 5.195465
16R:R:D101 8.23479
17R:R:R102 7.06479
18R:R:Y112 8.5375477
19R:R:V116 6.185407
20R:R:W143 7.275415
21R:R:C146 5.7125441
22R:R:P149 2.13405
23R:R:C159 4.215453
24R:R:F168 13.465414
25R:R:P173 5.8975414
26R:R:Y176 7.63716
27R:R:M177 4.508516
28R:R:N181 5.2325415
29R:R:F182 9.004505
30R:R:Y197 5.1775409
31R:R:F242 7.0375409
32R:R:W246 10.415408
33R:R:H250 10.4975406
34R:R:F257 9.22493
35R:R:H264 6.965412
36R:R:Y271 6.7575433
37R:R:H278 6.006536
38R:R:Y288 5.686529
39R:R:R291 7.6754107
40R:R:E294 6.2425426
41R:R:F295 7.07528
42R:R:T298 4.8975427
43L:L:?1 10.39551110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I60 R:R:V55 76.28283.07YesYes066
2R:R:S281 R:R:V55 98.6089.7NoYes096
3R:R:D52 R:R:S281 93.718311.78NoNo099
4R:R:D52 R:R:N24 1009.42NoYes099
5R:R:N24 R:R:P285 51.29089.77YesNo099
6R:R:A49 R:R:N24 49.33064.69NoYes099
7R:R:A49 R:R:V27 47.85343.39NoNo099
8R:R:V27 R:R:Y288 94.41785.05NoYes099
9R:R:F295 R:R:Y288 77.33745.16YesYes289
10R:R:F295 R:R:F299 25.62413.22YesNo086
11R:R:P285 R:R:V27 48.33633.53NoNo099
12R:R:F299 R:R:L26 21.675413.4NoNo066
13R:R:F295 R:R:L37 44.810212.18YesYes288
14R:R:L37 R:R:T298 17.92194.42YesYes287
15R:R:I302 R:R:T298 14.31413.04NoYes067
16R:R:I302 R:R:L26 14.0624.28NoNo066
17R:R:I302 R:R:W29 23.983512.92NoNo064
18R:R:H306 R:R:W29 12.03088.46NoNo044
19R:R:E294 R:R:L37 14.22893.98YesYes268
20R:R:V116 R:R:V40 13.02874.81YesNo076
21R:R:I104 R:R:V116 24.42383.07NoYes057
22R:R:I100 R:R:I104 29.29582.94NoNo065
23R:R:I100 R:R:L96 30.41094.28NoNo067
24R:R:L96 R:R:M193 31.61464.24NoNo078
25R:R:M193 R:R:V239 32.80074.56NoNo088
26R:R:L95 R:R:V239 33.97964.47NoNo088
27R:R:F242 R:R:L95 35.15153.65YesNo098
28R:R:F242 R:R:W246 48.197911.02YesYes098
29R:R:S277 R:R:W246 34.991714.83NoYes078
30R:R:H278 R:R:S277 36.06414.18YesNo067
31R:R:F44 R:R:I125 39.24936.28YesNo078
32R:R:I125 R:R:S47 40.46384.64NoNo089
33R:R:S47 R:R:S94 30.60263.26NoNo097
34R:R:L48 R:R:S94 30.76244.5NoNo097
35R:R:L48 R:R:S91 31.31643NoNo099
36I:I:?1 R:R:S91 32.11895.94NoNo009
37I:I:?1 R:R:D52 33.08488.05NoNo009
38R:R:F44 R:R:I98 35.54923.77YesNo078
39R:R:F242 R:R:I92 24.16465.02YesYes097
40R:R:I92 R:R:Q89 30.03446.86YesYes075
41R:R:Q89 R:R:S132 22.96084.33YesNo657
42R:R:S132 R:R:S90 24.78964.89NoNo076
43R:R:S90 R:R:W129 24.722118.53NoNo069
44R:R:L87 R:R:V55 65.34922.98NoYes076
45R:R:A59 R:R:V55 21.89555.09NoYes066
46R:R:F83 R:R:L87 63.5247.31YesNo057
47R:R:A59 R:R:V84 21.21733.39NoNo066
48R:R:F79 R:R:F83 59.77065.36NoYes445
49R:R:F79 R:R:M140 55.39933.73NoNo445
50R:R:L78 R:R:M140 54.94124.24YesNo465
51R:R:L78 R:R:V171 32.22542.98YesNo064
52R:R:C77 R:R:V171 14.54495.12NoNo094
53R:R:C166 R:R:C77 13.34477.28NoNo099
54R:R:C166 R:R:F70 11.11826.98NoYes097
55R:R:C159 R:R:N154 16.82474.72YesNo531
56R:R:E151 R:R:N154 19.171911.83NoNo521
57R:R:E151 R:R:P149 23.93033.14NoYes025
58R:R:P149 R:R:V164 30.97191.77YesNo054
59R:R:C74 R:R:V164 33.30496.83NoNo034
60R:R:C146 R:R:C74 17.66637.28YesNo013
61R:R:C146 R:R:L78 19.6693.17YesYes416
62R:R:C74 R:R:V171 18.13863.42NoNo034
63R:R:L85 R:R:V84 21.29542.98YesNo046
64R:R:H278 R:R:I274 32.95343.98YesNo064
65L:L:?1 R:R:I274 33.24813.69YesNo004
66L:L:?1 R:R:H250 20.13427.48YesYes006
67R:R:H250 R:R:N181 14.28223.83YesYes065
68R:R:H250 R:R:V186 17.85096.92YesNo067
69R:R:I98 R:R:L235 34.30285.71NoNo088
70R:R:A99 R:R:Y197 24.36355.34NoYes099
71R:R:L235 R:R:Y197 33.17714.69NoYes089
72R:R:A99 R:R:V196 23.05673.39NoNo097
73R:R:I200 R:R:V196 21.74283.07NoNo097
74R:R:I106 R:R:I200 15.06342.94NoNo089
75R:R:E228 R:R:I106 13.82765.47NoNo078
76R:R:F182 R:R:H250 20.166223.76YesYes056
77R:R:E228 R:R:L225 11.21761.33NoNo074
78L:L:?1 R:R:M270 10.09916.4YesNo104
79R:R:E294 R:R:Q297 10.48971.27YesNo064
80L:L:?1 R:R:W246 14.98883.68YesYes008
81R:R:I92 R:R:V186 14.90714.61YesNo077
82R:R:L85 R:R:N181 13.72118.24YesYes145
83R:R:S47 R:R:W129 25.07726.18NoNo099
84R:R:H278 R:R:I60 66.58856.63YesYes366
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:T88 R:R:W246 12.13 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 11.8 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 33.07 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 12.85 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 4.65 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 5.48 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 23.76 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:F242 R:R:W246 11.02 0 Yes Yes 9 8 2 1
R:R:S277 R:R:W246 14.83 0 No Yes 7 8 2 1
L:L:?1 R:R:W246 3.68 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 20.58 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 7.48 1 Yes Yes 0 6 0 1
R:R:I252 R:R:M270 4.37 0 No No 5 4 2 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 8.21 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 4.69 0 No Yes 3 3 1 2
L:L:?1 R:R:L267 5.37 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 6.4 1 Yes No 0 4 0 1
R:R:I274 R:R:Y271 3.63 0 No Yes 4 3 1 2
R:R:H278 R:R:I274 3.98 3 Yes No 6 4 2 1
L:L:?1 R:R:I274 3.69 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 3 Yes No 6 7 2 2
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single3EMLZM2413853EML-A2A-ZM241385
100.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
100.00Single6S0LZM2413856S0L-A2A-ZM241385
91.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
91.67Single6LPLZM2413856LPL-A2A-ZM241385-Na
91.67Single6S0QZM2413856S0Q-A2A-ZM241385
91.67Single6WQAZM2413856WQA-A2A-ZM241385-Na
91.67Single7RM5ZM2413857RM5-A2A-ZM241385-Na
91.67Single8FYNZM2413858FYN-A2A-ZM241385-Na
90.91Single5IU7Q274563465IU7-A2A-Q27456346-Na
90.91Single5JTBZM2413855JTB-A2A-ZM241385
90.91Single5K2BZM2413855K2B-A2A-ZM241385-Na
90.91Single5NLXZM2413855NLX-A2A-ZM241385-Na
90.91Single5UVIZM2413855UVI-A2A-ZM241385
90.91Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
83.33Single4EIYZM2413854EIY-A2A-ZM241385-Na
83.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
83.33Single5OLGZM2413855OLG-A2A-ZM241385-Na
83.33Single6LPJZM2413856LPJ-A2A-ZM241385-Na
83.33Single6LPKZM2413856LPK-A2A-ZM241385-Na
83.33Single7PYRPSB-21157PYR-A2A-PSB-2115
83.33Consensusa2_offOrthosteric Liganda2a_off
83.33Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
81.82Single5K2DZM2413855K2D-A2A-ZM241385
81.82Single6JZHZM2413856JZH-A2A-ZM241385-Na
81.82Single6PS7ZM2413856PS7-A2A-ZM241385-Na
81.82Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
81.82Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
76.92Single5NM2ZM2413855NM2-A2A-ZM241385-Na
76.92Single8GNEKW-63568GNE-A2A-KW-6356-Na
75.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
75.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
75.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
75.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
75.00Single6AQFZM2413856AQF-A2A-ZM241385
75.00Single6MH8ZM2413856MH8-A2A-ZM241385
71.43Single7PX4PSB-21137PX4-A2A-PSB-2113
71.43Consensusadenosine_offOrthosteric Liganda1_off a2_off
69.23Single8CU6LJ-45178CU6-A2A-LJ-4517
69.23Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
66.67Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
66.67Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
66.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
64.29Single5N2SPSB365N2S-A1-PSB36
64.29Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
64.29Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
64.29Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
61.54Single3REYPubChem 56973REY-A2A-PubChem 5697
61.54Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
61.54Single7AROLUF58337ARO-A2A-LUF5833-Na
61.54Single7T32ZM2413857T32-A2A-ZM241385
60.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
60.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
60.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
57.14Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
57.14Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
57.14Consensusadenosine_onOrthosteric Liganda1_on a2_on
57.14Consensusnucleotide_onOrthosteric Ligandadenosine_on
56.25Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
55.56Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
54.55Single3RFMCaffeine3RFM-A2A-Caffeine
54.55Single8A2OTheophylline8A2O-A2A-Theophylline-Na
53.85Single3PWHZM2413853PWH-A2A-ZM241385
53.85Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
53.85Single8GNGIstradefylline8GNG-A2A-Istradefylline
53.85Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
53.33Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
53.33Single8QOTNanobody E8QOT-μ-Nanobody E
53.33Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
52.94Single7EZCUKA7EZC-A2A-UKA
52.63Single3QAKUK-4320973QAK-A2A-UK-432097
50.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
50.00Single3UZAGTPL92363UZA-A2A-GTPL9236
50.00Single4UG2CGS216804UG2-A2A-CGS21680
50.00Single5WF6UK-4320975WF6-A2A-UK-432097
50.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
50.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
47.06Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
47.06Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
46.67Single5UENDU1725UEN-A1-DU172
46.67Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
46.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
46.67Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
46.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
46.15Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
46.15Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
45.45Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
45.45Single8PWNTheophylline8PWN-A2A-Theophylline
45.45Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
44.44Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
44.44Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
44.44Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
43.75Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
43.75Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
43.75Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
43.75Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
43.75Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single5WF5UK-4320975WF5-A2A-UK-432097
42.86Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single7F8ULintitript7F8U-CCKA-Lintitript
42.11Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
42.11Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Single2YDVNECA2YDV-A2A-NECA
41.18Single4UHRCGS216804UHR-A2A-CGS21680
41.18Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
41.18Single5G53NECA5G53-A2A-NECA-Gs
41.18Single6J21Aprepitant6J21-NK1-Aprepitant
41.18Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
41.18Single7W41PD1762527W41-BB2-PD176252
41.18Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
41.18Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
41.18Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
41.18Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
41.18Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
41.18Consensusbombesin_offOrthosteric Ligandbb2_off
41.18Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.91Single7C61Ergotamine7C61-5-HT1B-Ergotamine
40.00Single2YDOAdenosine2YDO-A2A-Adenosine
40.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
40.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
40.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
40.00Single7F8XNN90567F8X-CCKA-NN9056
40.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
40.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
39.13Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
38.89Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
38.89Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
38.89Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
38.89Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
38.89Single7YITNalfurafine7YIT-κ-Nalfurafine
38.89Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
38.89Single8JWZAB9288JWZ-A2A-AB928-Na
38.89Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
38.89Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
38.89Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
38.46Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
38.10Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
38.10Single6HLOAprepitant6HLO-NK1-Aprepitant
38.10Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
38.10Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
37.50Single3NY8ICI 118-5513NY8-β2-ICI 118-551
37.50Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
37.50Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
37.50Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
37.50Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
37.50Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
37.50Single6PS1Timolol6PS1-β2-Timolol
37.50Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
37.50Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
37.50Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
37.50Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8JJOAlprenolol8JJO-β2-Alprenolol
37.50Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
37.50Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
37.50Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
36.84Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
36.84Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
36.84Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
36.84Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
36.84Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
36.84Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
36.84Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
36.84Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
36.84Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
36.36Single5MZPCaffeine5MZP-A2A-Caffeine-Na
36.36Single6PT2KGCHM076PT2-δ-KGCHM07
36.36Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
36.36Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
36.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
35.71Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
35.71Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
35.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.71Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.29Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
35.29Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
35.29Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
35.29Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
35.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
35.29Single6PS6Timolol6PS6-β2-Timolol
35.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
35.29Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
35.29Single7SINNPS-21437SIN-CaS-NPS-2143
35.29Single7SINNPS-21437SIN-CaS-NPS-2143
35.29Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single7XKAEpinephrine7XKA-β2-Epinephrine
35.29Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
35.29Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
35.29Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
35.29Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
35.29Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
35.29Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
35.29Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
35.00Single6PT3DPI-2876PT3-δ-DPI-287
35.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
35.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
35.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
35.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
35.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
35.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
35.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
34.78Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
34.78Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
34.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
34.78Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.78Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
34.62Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
34.62Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single3P0GBI1671073P0G-β2-BI167107
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
33.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
33.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
33.33Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
33.33Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
33.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
33.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
33.33Single6J20Aprepitant6J20-NK1-Aprepitant
33.33Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
33.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
33.33Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
33.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7TUYGSK682753A7TUY-GPR183-GSK682753A
33.33Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
33.33Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
33.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
33.33Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
33.33Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
33.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
33.33Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
33.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
33.33Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
33.33Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
33.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
33.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
33.33Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
33.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensus5ht5_offOrthosteric Ligand5ht5a_off
33.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
33.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
33.33Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
33.33Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
33.33Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
33.33Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
33.33Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
33.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
33.33Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
33.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
33.33Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
33.33Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
33.33Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensusmglu_onOther Ligandmglu2_on mglu4_on
33.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
33.33Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
33.33Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
32.14Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
32.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
32.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
32.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
32.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
32.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
32.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
31.82Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.82Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
31.82Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.82Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
31.58Single4AMIBucindolol4AMI-β1-Bucindolol
31.58Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.58Single4XEENeurotensin4XEE-NTS1-Neurotensin
31.58Single4XESNeurotensin4XES-NTS1-Neurotensin
31.58Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
31.58Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
31.58Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
31.58Single6MXTSalmeterol6MXT-β2-Salmeterol
31.58Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
31.58Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
31.58Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
31.58Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
31.58Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
31.58Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
31.58Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
31.58Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
31.58Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
31.58Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
31.58Single8JJ8Formoterol8JJ8-β2-Formoterol
31.58Single8JJLOlodaterol8JJL-β2-Olodaterol
31.58Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
31.58Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
31.58Consensusclass-b2_onOrthosteric Ligandadgrg_on
31.58Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
31.58Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
31.58Consensusdp_offOrthosteric Liganddp2_off
31.58Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
31.58Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
31.58Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.58Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
31.58Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
31.25Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
31.25Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
31.25Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
31.25Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
31.25Single6PS4ICI 118-5516PS4-β2-ICI 118-551
31.25Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
31.25Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
31.25Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
31.25Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
31.25Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GGKEpinephrine8GGK-β2-Epinephrine
31.25Single8GGMEpinephrine8GGM-β2-Epinephrine
31.25Single8GGPEpinephrine8GGP-β2-Epinephrine
31.25Single8GGQEpinephrine8GGQ-β2-Epinephrine
31.25Single8GGTEpinephrine8GGT-β2-Epinephrine
31.25Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
31.25Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
31.25Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
31.25Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
31.25Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
31.25Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
31.25Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
31.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
30.77Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
30.77Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
30.77Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
30.77Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
30.43Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
30.43Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
30.43Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
30.43Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
30.43Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
30.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
30.00Single6IBLArformoterol6IBL-β1-Arformoterol
30.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
30.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
30.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
30.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
30.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
30.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
30.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
30.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
30.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
30.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
30.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
30.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
30.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
30.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusorexin_onOrthosteric Ligandox2_on
29.63Single6IGLIRL16206IGL-ETB-IRL1620
29.63Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
29.63Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
29.63Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.63Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
29.63Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
29.41Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
29.41Single2Y02Carmoterol2Y02-β1-Carmoterol
29.41Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
29.41Single4EJ4Naltrindole4EJ4-δ-Naltrindole
29.41Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
29.41Single6D27CAY104716D27-DP2-CAY10471
29.41Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
29.41Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
29.41Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
29.41Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
29.41Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
29.41Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
29.41Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
29.41Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
29.41Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
29.41Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
29.41Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
29.41Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
29.41Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
29.41Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
29.41Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
29.41Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
29.41Single7WC7Lisuride7WC7-5-HT2A-Lisuride
29.41Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
29.41Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
29.41Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8GGJEpinephrine8GGJ-β2-Epinephrine
29.41Single8GGNEpinephrine8GGN-β2-Epinephrine
29.41Single8GGOEpinephrine8GGO-β2-Epinephrine
29.41Single8GGUEpinephrine8GGU-β2-Epinephrine
29.41Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
29.41Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
29.41Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Single8X63Mepyramine8X63-H1-Mepyramine
29.41Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
29.41Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
29.41Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
29.41Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
29.41Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
29.41Consensuscck_offOrthosteric Ligandccka_off
29.41Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
29.41Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
29.41Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
29.41Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
29.41Consensustachykinin_offOrthosteric Ligandnk1_off
29.41Consensustar_onOrthosteric Ligandta1_on
29.17Single6JODAngiotensin II6JOD-AT2-Angiotensin II
29.17Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.17Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
28.57Single4XNWMRS25004XNW-P2Y1-MRS2500
28.57Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
28.57Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
28.57Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
28.57Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
28.57Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
28.57Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
28.57Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
28.57Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7XN9L-054,5227XN9-SST2-L-054,522
28.57Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
28.57Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
28.57Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
28.57Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
28.57Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
28.57Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
28.57Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
28.57Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
28.57Consensuslpl_offOrthosteric Ligands1p_off lpa_off
28.57Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
28.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
28.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
28.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single5C1MBU725C1M-μ-BU72
27.78Single5TVNLSD5TVN-5-HT2B-LSD
27.78Single5XPRBosentan5XPR-ETB-Bosentan
27.78Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
27.78Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.78Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
27.78Single6E67BI1671076E67-β2-BI167107-Gs (fused)
27.78Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
27.78Single6LUQHaloperidol6LUQ-D2-Haloperidol
27.78Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
27.78Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
27.78Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
27.78Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
27.78Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
27.78Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
27.78Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
27.78Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
27.78Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
27.78Single7WC6LSD7WC6-5-HT2A-LSD
27.78Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.78Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.78Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
27.78Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
27.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
27.78Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
27.78Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
27.78Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
27.78Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
27.78Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
27.78Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
27.78Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
27.78Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
27.59Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
27.27Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
27.27Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
27.27Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
27.27Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
27.27Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
27.27Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
27.27Consensussst_onOrthosteric Ligandsst2_on sst4_on
26.92Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
26.92Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
26.92Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
26.67Single3PBLEticlopride3PBL-D3-Eticlopride
26.67Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
26.67Single6HLLCP999946HLL-NK1-CP99994
26.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
26.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
26.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
26.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
26.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
26.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
26.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
26.67Single8GGSEpinephrine8GGS-β2-Epinephrine
26.67Single8GGYEpinephrine8GGY-β2-Epinephrine
26.67Single8GH1Epinephrine8GH1-β2-Epinephrine
26.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
26.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
26.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
26.67Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
26.67Consensusgo_proteinOrthosteric Ligandgo_chemokine
26.67Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
26.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.32Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
26.32Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
26.32Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
26.32Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.32Single4RWADIPP-NH24RWA-δ-DIPP-NH2
26.32Single5V54Methiothepin5V54-5-HT1B-Methiothepin
26.32Single5V56TC1145V56-SMO-TC114
26.32Single5X93K-87945X93-ETB-K-8794
26.32Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
26.32Single6E59L-7607356E59-NK1-L-760735
26.32Single6H7JIsoprenaline6H7J-β1-Isoprenaline
26.32Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
26.32Single6TQ7SB-3348676TQ7-OX1-SB-334867
26.32Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
26.32Single6WGTLSD6WGT-5-HT2A-LSD
26.32Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.32Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
26.32Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.32Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
26.32Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
26.32Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
26.32Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
26.32Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
26.32Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
26.32Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
26.32Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single8E0GBU728E0G-μ-BU72
26.32Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
26.32Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.32Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
26.32Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
26.32Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensus5ht1_offOrthosteric Ligand5ht1b_off
26.32Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
26.32Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
26.32Consensuschemerin_onOrthosteric Ligandcml1_on
26.32Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.32Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.32Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.32Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
26.32Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.32Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
26.32Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
26.32Consensushistamine_offOrthosteric Ligandh1_off
26.32Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Consensuslpa_onOrthosteric Ligandlpa1_on
26.32Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
26.32Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
26.32Consensusrelaxin_onOrthosteric Ligandrxfp4_on
26.32Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.09Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
26.09Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
26.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
26.09Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.93Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.81Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
25.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
25.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
25.00Single4LDEBI1671074LDE-β2-BI167107
25.00Single6A93Risperidone6A93-5-HT2A-Risperidone
25.00Single6CM4Risperidone6CM4-D2-Risperidone
25.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
25.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
25.00Single6HLPNetupitant6HLP-NK1-Netupitant
25.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
25.00Single6KUXRS-799486KUX-α2a-RS-79948
25.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
25.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
25.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
25.00Single6OS2TRV0266OS2-AT1-TRV026
25.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
25.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
25.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
25.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
25.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
25.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
25.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
25.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
25.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
25.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
25.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
25.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGVEpinephrine8GGV-β2-Epinephrine
25.00Single8GGXEpinephrine8GGX-β2-Epinephrine
25.00Single8GH0Epinephrine8GH0-β2-Epinephrine
25.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
25.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
25.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
25.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
25.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
25.00Consensusangiotensin_onOrthosteric Ligandat1_on
25.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
25.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
25.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
25.00Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
25.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
25.00Consensusgi_class-fOther Ligandgi_frizzled
25.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
25.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
25.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
25.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgt_class-aOrthosteric Ligandgt_opsin
25.00Consensusgt_opsinOrthosteric Ligandgt_sensory
25.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
25.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
25.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
25.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
25.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
25.00Consensusnts_offOrthosteric Ligandnts1_off
25.00Consensusnts_onOrthosteric Ligandnts1_on
25.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
24.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
24.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
24.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
24.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
24.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
24.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
24.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
23.81Single6H7LDobutamine6H7L-β1-Dobutamine
23.81Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
23.81Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
23.81Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
23.81Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
23.81Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
23.81Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
23.81Consensusendothelin_offOrthosteric Ligandetb_off
23.81Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
23.81Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.81Consensussteroid_onOrthosteric Ligandbileacid_on
23.53Single3RZECidoxepin3RZE-H1-Cidoxepin
23.53Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
23.53Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
23.53Single6A94Zotepine6A94-5-HT2A-Zotepine
23.53Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
23.53Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
23.53Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.53Single6TPGEMPA6TPG-OX2-EMPA
23.53Single6TPKRetosiban6TPK-OT-Retosiban
23.53Single6TPNHTL66416TPN-OX2-HTL6641
23.53Single6V9SGTPL114036V9S-OX1-GTPL11403
23.53Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
23.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.53Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
23.53Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.53Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.53Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
23.53Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
23.53Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
23.53Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
23.53Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
23.53Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
23.53Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
23.53Single7VV6C48/807VV6-MRGPRX2-C48/80
23.53Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
23.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.53Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
23.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGIEpinephrine8GGI-β2-Epinephrine
23.53Single8GGLEpinephrine8GGL-β2-Epinephrine
23.53Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
23.53Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
23.53Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
23.53Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
23.53Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Consensus5ht5_onOrthosteric Ligand5ht5a_on
23.53Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
23.53Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
23.53Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.53Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.53Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
23.53Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
23.53Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
23.53Consensusgnrh_offOrthosteric Ligandgnrh1_off
23.53Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
23.53Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
23.53Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
23.53Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
23.53Consensussensory_offOrthosteric Ligandopsin_off
23.53Consensusvasopressin-ot_offOrthosteric Ligandot_off
23.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
23.33Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
23.08Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.08Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
23.08Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
23.08Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single5ZTYAM102575ZTY-CB2-AM10257
22.73Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.73Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
22.73Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
22.73Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
22.73Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
22.73Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
22.73Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
22.73Single8X5YAstemizole8X5Y-H1-Astemizole
22.73Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
22.73Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
22.73Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusgs_class-b2Orthosteric Ligandgs_adgr
22.73Consensuslpl_onOrthosteric Ligands1p_on lpa_on
22.73Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
22.73Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
22.22Single2Y01Dobutamine2Y01-β1-Dobutamine
22.22Single2Y04Salbutamol2Y04-β1-Salbutamol
22.22Single4DAJTiotropium4DAJ-M3-Tiotropium
22.22Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single4MQSIperoxo4MQS-M2-Iperoxo
22.22Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
22.22Single4U14Tiotropium4U14-M3-Tiotropium
22.22Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
22.22Single5DSGTiotropium5DSG-M4-Tiotropium
22.22Single5TGZAM65385TGZ-CB1-AM6538
22.22Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
22.22Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
22.22Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
22.22Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
22.22Single6H7MSalbutamol6H7M-β1-Salbutamol
22.22Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
22.22Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
22.22Single7BU7BI1671077BU7-β1-BI167107
22.22Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
22.22Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
22.22Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
22.22Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
22.22Single7UL4Alvimopan7UL4-μ-Alvimopan
22.22Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
22.22Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.22Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
22.22Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.22Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
22.22Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
22.22Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
22.22Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.22Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
22.22Single8X64Desloratadine8X64-H1-Desloratadine
22.22Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
22.22Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
22.22Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.22Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.22Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
22.22Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
22.22Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
22.22Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
22.22Consensushistamine_onOrthosteric Ligandh1_on h4_on
22.22Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
22.22Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.22Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
21.74Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
21.74Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
21.74Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
21.74Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
21.74Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
21.74Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
21.43Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
21.43Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.43Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
21.43Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
21.43Consensusgo_class-b1Orthosteric Ligandgo_crf
21.43Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.43Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
21.43Consensussensory_onOrthosteric Ligandopsin_on
21.05Single2Y00Dobutamine2Y00-β1-Dobutamine
21.05Single2Y03Isoprenaline2Y03-β1-Isoprenaline
21.05Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
21.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
21.05Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
21.05Single5WQCEMPA5WQC-OX2-EMPA
21.05Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.05Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
21.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
21.05Single6Z4SSR486926Z4S-NTS1-SR48692
21.05Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
21.05Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
21.05Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
21.05Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
21.05Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
21.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
21.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
21.05Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
21.05Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8EA0Iperoxo8EA0-M3-Iperoxo
21.05Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
21.05Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
21.05Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.05Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
21.05Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
21.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
21.05Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
21.05Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
21.05Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
21.05Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
21.05Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.83Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.83Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
20.83Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.83Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
20.83Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
20.83Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
20.83Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
20.83Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.83Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.83Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
20.83Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.83Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
20.83Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
20.69Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
20.69Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
20.69Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
20.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.00Single4U15Tiotropium4U15-M3-Tiotropium
20.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
20.00Single5V57TC1145V57-SMO-TC114
20.00Single5XRAAM115425XRA-CB1-AM11542
20.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
20.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
20.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single6OL9Tiotropium6OL9-M5-Tiotropium
20.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
20.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
20.00Single7EPENAM5637EPE-mGlu-NAM563
20.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
20.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
20.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
20.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
20.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.00Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
20.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
20.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.00Single7XNACYN1548067XNA-SST2-CYN154806
20.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8GGREpinephrine8GGR-β2-Epinephrine
20.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
20.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
20.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
20.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
20.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
20.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
20.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
20.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
20.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
20.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
20.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
20.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
19.23Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
19.05Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
19.05Single4N4WSANT-14N4W-SMO-SANT-1
19.05Single5CXVTiotropium5CXV-M1-Tiotropium
19.05Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
19.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.05Single7DFPSpiperone7DFP-D2-Spiperone
19.05Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
19.05Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
19.05Single7K15MKD0467K15-BLT1-MKD046-Na
19.05Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
19.05Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
19.05Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
19.05Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
19.05Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
19.05Consensusblt_offOrthosteric Ligandblt1_off
19.05Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
19.05Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
19.05Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
19.05Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
18.75Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
18.75Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
18.75Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
18.75Single3OE9IT1t3OE9-CXCR4-IT1t
18.75Single5L7IVismodegib5L7I-SMO-Vismodegib
18.75Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
18.75Single6TP4ACT-4622066TP4-OX1-ACT-462206
18.75Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
18.75Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
18.75Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single7SRQLSD7SRQ-5-HT2B-LSD
18.75Single7UL2SR486927UL2-NTS1-SR48692-Na
18.75Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
18.75Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
18.75Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.75Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.75Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
18.75Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
18.75Single8K5BNiacin8K5B-HCA2-Niacin
18.75Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.75Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.75Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.75Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
18.75Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
18.75Consensusgo_class-b2Orthosteric Ligandgo_adhesion
18.75Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
18.75Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
18.75Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.52Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.52Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
18.52Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
18.52Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
18.52Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.52Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.52Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
18.52Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.18Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
18.18Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
18.18Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
18.18Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
18.18Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
18.18Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
18.18Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
18.18Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
18.18Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
18.18Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
18.18Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
18.18Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
18.18Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
18.18Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
18.18Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
18.18Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
18.18Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
18.18Consensuscyslt_offOrthosteric Ligandcyslt2_off
18.18Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.86Single4XT3Fractalkine4XT3-US28-Fractalkine
17.86Single6FJ3PTH6FJ3-PTH1-PTH
17.86Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
17.86Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
17.86Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
17.86Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.86Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
17.65Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
17.65Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
17.65Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
17.65Single4S0VSuvorexant4S0V-OX2-Suvorexant
17.65Single5WS3EMPA5WS3-OX2-EMPA
17.65Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.65Single6AKXA4R6AKX-CCR5-A4R
17.65Single6TODEMPA6TOD-OX1-EMPA-Na
17.65Single6TPJSuvorexant6TPJ-OX2-Suvorexant
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
17.65Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
17.65Single7F8YDevazepide7F8Y-CCKA-Devazepide
17.65Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
17.65Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
17.65Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
17.65Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
17.65Single7XRRLemborexant7XRR-OX2-Lemborexant
17.65Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single8GGWEpinephrine8GGW-β2-Epinephrine
17.65Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
17.65Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8IWESpermidine8IWE-TAAR9-Spermidine
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.65Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
17.65Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
17.65Consensusclass-f_offOrthosteric Ligandsmo_off
17.65Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
17.65Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.65Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
17.65Consensusorexin_offOrthosteric Ligandox2_off ox1_off
17.39Single5EE7MK08935EE7-Glucagon-MK0893
17.39Single6KNMJN241-96KNM-Apelin-JN241-9
17.39Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
17.39Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7SK9CCX6627SK9-ACKR3-CCX662
17.39Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
17.39Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
17.39Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
17.39Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.24Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.24Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.24Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
17.24Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
17.24Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
16.67Single4XT1Fractalkine4XT1-US28-Fractalkine
16.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
16.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
16.67Single6IQLL7458706IQL-D4-L745870
16.67Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
16.67Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
16.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.67Single6ZINSR486926ZIN-NTS1-SR48692
16.67Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
16.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
16.67Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
16.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
16.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
16.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
16.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
16.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
16.67Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
16.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
16.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
16.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
16.67Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
16.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
16.67Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
16.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
16.67Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
16.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
16.67Single8K5CAcipimox8K5C-HCA2-Acipimox
16.67Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
16.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
16.67Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.67Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
16.67Consensushca_onOrthosteric Ligandhca2_on hca3_on
16.67Consensushcar_onOrthosteric Ligandhca_on
16.67Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
16.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
16.13Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.13Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.00Single7SK5CXCL127SK5-ACKR3-CXCL12
16.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensussst_offOrthosteric Ligandsst2_off
16.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
15.79Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
15.79Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
15.79Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
15.79Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
15.79Single6DRXLisuride6DRX-5-HT2B-Lisuride
15.79Single6IIVDaltroban6IIV-TP-Daltroban
15.79Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
15.79Single6TOTLemborexant6TOT-OX1-Lemborexant
15.79Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
15.79Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
15.79Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.79Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
15.79Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
15.79Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
15.79Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
15.79Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
15.79Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.79Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
15.79Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
15.79Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.79Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
15.79Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
15.79Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.79Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
15.79Consensusgi_hcarOrthosteric Ligandgi_hca
15.79Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.79Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
15.79Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.79Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.79Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
15.79Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
15.62Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
15.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
15.62Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
15.38Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.38Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
15.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
15.38Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.38Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.15Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
15.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
15.00Single5CGCHTL142425CGC-mGlu5-HTL14242
15.00Single5WIUNemonapride5WIU-D4-Nemonapride
15.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.00Single6TP6Filorexant6TP6-OX1-Filorexant
15.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
15.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
15.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
15.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.00Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
15.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
15.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
15.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
15.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
14.81Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.81Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
14.81Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
14.81Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.81Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
14.81Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
14.81Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
14.71Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
14.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
14.71Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
14.71Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
14.29Single4DJHJDTic4DJH-κ-JDTic
14.29Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
14.29Single5XR8AM8415XR8-CB1-AM841
14.29Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.29Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
14.29Single6OS1TRV0266OS1-AT1-TRV026
14.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
14.29Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
14.29Single7P2L4YI7P2L-mGlu5-4YI
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
14.29Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
14.29Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
14.29Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
14.29Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
14.29Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
14.29Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
14.29Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
14.29Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
14.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
14.29Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
14.29Consensusclass-c_onOther Ligandgabab_on mglu_on
14.29Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
14.29Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
14.29Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
14.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
14.29Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.79Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.79Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.79Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
13.79Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7SK3CXCL127SK3-ACKR3-CXCL12
13.79Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusclass-d_onOrthosteric Ligandste2_on
13.79Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.79Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.64Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.64Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.64Single6IIURamatroban6IIU-TP-Ramatroban
13.64Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
13.64Single6ZG4HTL00099366ZG4-M1-HTL0009936
13.64Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
13.64Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.64Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.64Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
13.64Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
13.64Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
13.64Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
13.64Consensuschemokine_offOrthosteric Ligandcxcr_off
13.64Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
13.64Consensuscxcr_offOrthosteric Ligandcxcr4_off
13.64Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
13.51Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
13.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
13.33Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
13.33Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.33Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
13.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
13.33Consensusgi_class-dOrthosteric Ligandgi_ste
13.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.16Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.16Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.04Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
13.04Single5CGDHTL142425CGD-mGlu5-HTL14242
13.04Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
13.04Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.04Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
13.04Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.90Single6LMLGlucagon6LML-Glucagon-Glucagon
12.90Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
12.90Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.90Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.90Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
12.90Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.90Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.50Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
12.50Single6LI0GTPL98046LI0-GPR52-GTPL9804
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
12.50Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
12.50Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
12.50Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
12.50Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
12.50Consensusclass-d_offOrthosteric Ligandste2_off
12.50Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.50Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.12Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
12.12Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.12Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
12.00Single7QA8Peptide7QA8-STE2-Peptide
12.00Single7QA8Peptide7QA8-STE2-Peptide
12.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
12.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
12.00Consensusclass-d_offOrthosteric Ligandste2_off
12.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
11.76Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.76Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.76Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
11.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.76Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
11.76Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
11.76Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.76Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
11.76Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
11.76Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
11.76Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
11.76Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
11.76Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.76Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
11.54Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.54Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
11.43Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5DHHSB-6121115DHH-NOP-SB-612111
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6AKYMaraviroc6AKY-CCR5-Maraviroc
11.11Single6B73PubChem 1319551386B73-κ-PubChem 131955138
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.11Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
11.11Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
11.11Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
11.11Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
11.11Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
11.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.11Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
11.11Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.81Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.71Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.71Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.71Consensusclass-d_onOrthosteric Ligandste2_on
10.71Consensusgi_class-dOrthosteric Ligandgi_ste
10.71Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.71Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.71Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.53Single6VI4JDTic6VI4-κ-JDTic
10.53Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.53Single6ZG9GSK10347026ZG9-M1-GSK1034702
10.53Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
10.53Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.53Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.53Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.53Single8K2WAMG4878K2W-CXCR3-AMG487
10.53Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.53Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
10.53Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.53Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.53Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.53Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
10.34Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.34Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.00Single4YAYZD-71554YAY-AT1-ZD-7155
10.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
10.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
10.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.00Single5T04Neurotensin5T04-NTS1-Neurotensin
10.00Single6FFHFenobam6FFH-mGlu5-Fenobam
10.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
10.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
10.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
10.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
10.00Single8K5DGSK2560738K5D-HCA2-GSK256073
10.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.00Consensusblt_onOrthosteric Ligandblt1_on
10.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
10.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.00Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
10.00Consensusleuko_onOrthosteric Ligandblt_on
10.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
9.68Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
9.68Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
9.68Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.68Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.52Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.52Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.52Single7C4SS1P7C4S-S1P3-S1P
9.52Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
9.52Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.52Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
9.52Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
9.52Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
9.52Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
9.52Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.52Consensusep_offOrthosteric Ligandep4_off
9.38Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.09Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
9.09Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.70Single5X33BIIL2605X33-BLT1-BIIL260
8.70Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
8.70Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
8.33Single6K1QIRL25006K1Q-ETB-IRL2500
8.33Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
8.33Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
8.33Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7.69Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
7.14Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.14Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
6.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.67Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
6.25Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
6.25Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.25Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.25Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.25Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
6.25Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.88Single3OE8IT1t3OE8-CXCR4-IT1t
5.88Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.88Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.88Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.88Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.56Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
5.56Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
5.56Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusclass-t_onOrthosteric Ligandtaste2_on
5.56Consensusgs_class-tOrthosteric Ligandgs_taste
5.56Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.26Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.26Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.26Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8IHKAcifran8IHK-HCA3-Acifran
5.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
5.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
5.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
5.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
5.00Consensuss1p_offOrthosteric Ligands1p1_off
4.76Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.76Single6GPSMK08126GPS-CCR2-MK0812
4.76Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.76Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Consensushcar_offOrthosteric Ligandsuccinate_off
4.76Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.55Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.55Single6GPXMK08126GPX-CCR2-MK0812
4.55Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.55Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
4.55Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.55Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
4.35Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.35Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
4.35Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.17Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.17Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
4.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.70Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.57Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
2.94Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.86Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.78Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.33Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.22Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 5K2A
Class A
SubFamily Nucleotide
Type Adenosine
SubType A2A
Species Homo sapiens
Ligand ZM241385
Other Ligand(s) Na
Protein Partners -
PDB Resolution 2.5
Date 2016-09-21
D.O.I. 10.1126/sciadv.1600292
Net Summary
Imin 2.98
Number of Linked Nodes 276
Number of Links 322
Number of Hubs 43
Number of Links mediated by Hubs 157
Number of Communities 11
Number of Nodes involved in Communities 71
Number of Links involved in Communities 91
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 64306
Length Of Smallest Path 3
Average Path Length 16.1527
Length of Longest Path 39
Minimum Path Strength 1.03
Average Path Strength 6.03082
Maximum Path Strength 21.4367
Minimum Path Correlation 0.7
Average Path Correlation 0.931171
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 46.7966
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.0908
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeZMA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeZMA
Name4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Synonyms4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Identifier4-[2-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-e][1,3,5]triazin-5-yl]amino]ethyl]phenol
FormulaC16 H15 N7 O2
Molecular Weight337.336
SMILESc1cc(oc1)c2nc3nc(nc(n3n2)N)NCCc4ccc(cc4)O
PubChem176407
Formal Charge0
Total Atoms40
Total Chiral Atoms0
Total Bonds43
Total Aromatic Bonds22

CodeNA
PDB ResiduesI:I:?1
Environment DetailsOpen EMBL-EBI Page
CodeNA
NameSODIUM ION
Synonyms
Identifiersodium(+1) cation
FormulaNa
Molecular Weight22.99
SMILES[Na+]
PubChem
Formal Charge1
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP29274
Sequence
>5K2A_Chain_R
PPIMGSSVY ITVELAIAV LAILGNVLV CWAVWLNSN LQNVTNYFV 
VSLAAADIA VGVLAIPFA ITISTGFCA ACHGCLFIA CFVLVLTQS 
SIFSLLAIA IDRYIAIRI PLRYNGLVT GTRAKGIIA ICWVLSFAI 
GLTPMLGWN NCGQPKEGK NHSQGCGEG QVACLFEDV VPMNYMVYF 
NFFACVLVP LLLMLGVYL RIFLAARRQ LERARSTLQ KEVHAAKSL 
AIIVGLFAL CWLPLHIIN CFTFFCPDC SHAPLWLMY LAIVLSHTN 
SVVNPFIYA YRIREFRQT FRKIIRSHV L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2YDOANucleotideAdenosineA2AHomo sapiensAdenosine--32011-05-1810.1038/nature10136
2YDVANucleotideAdenosineA2AHomo sapiensNECA--2.62011-05-1810.1038/nature10136
3EMLANucleotideAdenosineA2AHomo sapiensZM241385--2.62008-10-1410.1126/science.1164772
3PWHANucleotideAdenosineA2AHomo sapiensZM241385--3.32011-09-0710.1016/j.str.2011.06.014
3QAKANucleotideAdenosineA2AHomo sapiensUK-432097--2.712011-03-0910.1126/science.1202793
3REYANucleotideAdenosineA2AHomo sapiensPubChem 5697--3.312011-09-0710.1016/j.str.2011.06.014
3RFMANucleotideAdenosineA2AHomo sapiensCaffeine--3.62011-09-0710.1016/j.str.2011.06.014
3UZAANucleotideAdenosineA2AHomo sapiensGTPL9236--3.272012-03-2110.1021/jm201376w
3UZCANucleotideAdenosineA2AHomo sapiensPubChem 135566609--3.342012-03-2110.1021/jm201376w
3VG9ANucleotideAdenosineA2AHomo sapiensZM241385Antibody-2.72012-02-0110.1038/nature10750
3VGAANucleotideAdenosineA2AHomo sapiensZM241385Antibody-3.12012-02-0110.1038/nature10750
4EIYANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82012-07-2510.1126/science.1219218
4UG2ANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
4UHRANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
5G53ANucleotideAdenosineA2AHomo sapiensNECA-Gs3.42016-08-0310.1038/nature18966
5IU4ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.722016-06-2910.1021/acs.jmedchem.6b00653
5IU7ANucleotideAdenosineA2AHomo sapiensQ27456346Na-1.92016-06-2910.1021/acs.jmedchem.6b00653
5IU8ANucleotideAdenosineA2AHomo sapiensQ27456347Na-22016-06-2910.1021/acs.jmedchem.6b00653
5IUAANucleotideAdenosineA2AHomo sapiensQ27456348Na-2.22016-06-2910.1021/acs.jmedchem.6b00653
5IUBANucleotideAdenosineA2AHomo sapiensQ27456344Na-2.12016-06-2910.1021/acs.jmedchem.6b00653
5JTBANucleotideAdenosineA2AHomo sapiensZM241385--2.82017-05-3110.1126/sciadv.1602952
5K2BANucleotideAdenosineA2AHomo sapiensZM241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2CANucleotideAdenosineA2AHomo sapiensZM241385Na-1.92016-09-2110.1126/sciadv.1600292
5K2DANucleotideAdenosineA2AHomo sapiensZM241385--1.92016-09-2110.1126/sciadv.1600292
5MZJANucleotideAdenosineA2AHomo sapiensTheophyllineNa-22017-07-2610.1016/j.str.2017.06.012
5MZPANucleotideAdenosineA2AHomo sapiensCaffeineNa-2.12017-07-2610.1016/j.str.2017.06.012
5N2RANucleotideAdenosineA2AHomo sapiensPubChem 92460631; psb36Na-2.82017-07-2610.1016/j.str.2017.06.012
5NLXANucleotideAdenosineA2AHomo sapiensZM241385Na-2.142017-09-2710.1038/s41467-017-00630-4
5NM2ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.952017-09-2710.1038/s41467-017-00630-4
5NM4ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.72017-09-2710.1038/s41467-017-00630-4
5OLGANucleotideAdenosineA2AHomo sapiensZM241385Na-1.872018-01-1710.1038/s41598-017-18570-w
5OLHANucleotideAdenosineA2AHomo sapiensVipadenantNa-2.62018-01-1710.1038/s41598-017-18570-w
5OLOANucleotideAdenosineA2AHomo sapiensTozadenantNa-3.12018-01-1710.1038/s41598-017-18570-w
5OLVANucleotideAdenosineA2AHomo sapiensLUAA41063Na-22018-01-1710.1038/s41598-017-18570-w
5OLZANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-1.92018-01-1710.1038/s41598-017-18570-w
5OM1ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-2.12018-01-1710.1038/s41598-017-18570-w
5OM4ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-22018-01-1710.1038/s41598-017-18570-w
5UIGANucleotideAdenosineA2AHomo sapiensJ3.651.884G--3.52017-02-0810.1073/pnas.1621423114
5UVIANucleotideAdenosineA2AHomo sapiensZM241385--3.22017-05-2410.1107/S205225251700570X
5VRAANucleotideAdenosineA2AHomo sapiensZM241385Na-2.352017-12-1310.1038/nprot.2017.135
5WF5ANucleotideAdenosineA2AHomo sapiensUK-432097--2.62018-02-2110.1016/j.str.2017.12.013
5WF6ANucleotideAdenosineA2AHomo sapiensUK-432097--2.92018-02-2110.1016/j.str.2017.12.013
6AQFANucleotideAdenosineA2AHomo sapiensZM241385--2.512018-01-1010.1016/j.cell.2017.12.004
6GDGANucleotideAdenosineA2AHomo sapiensNECA-Gs/&β;1/&γ;14.112018-05-1610.7554/eLife.35946
6GT3ANucleotideAdenosineA2AHomo sapiensImaradenantNa-22019-06-2610.1136/jitc-2019-000417
6JZHANucleotideAdenosineA2AHomo sapiensZM241385Na-2.252019-10-3010.1107/S1600576719012846
6LPJANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPKANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPLANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-2510.1038/s41598-020-76277-x
6MH8ANucleotideAdenosineA2AHomo sapiensZM241385--4.22019-04-2410.1107/S205225251900263X
6PS7ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.852019-11-1310.1107/S2052252519013137
6S0LANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6S0QANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6WQAANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-1810.1107/S2052252520012701
6ZDRANucleotideAdenosineA2AHomo sapiensHMS1413f12Na-1.922020-09-1610.1002/anie.202003788
6ZDVANucleotideAdenosineA2AHomo sapiensPubChem 984073Na-2.132020-09-1610.1002/anie.202003788
7AROANucleotideAdenosineA2AHomo sapiensLUF5833Na-3.122021-04-0710.1021/acs.jmedchem.0c01856
7EZCANucleotideAdenosineA2AHomo sapiensUKA--3.82022-04-1310.1107/S2052252522001907
7PX4ANucleotideAdenosineA2AHomo sapiensPSB-2113--2.252022-03-0210.1002/anie.202115545
7PYRANucleotideAdenosineA2AHomo sapiensPSB-2115--2.62022-03-0210.1002/anie.202115545
7RM5ANucleotideAdenosineA2AHomo sapiensZM241385Na-2.792021-09-0810.1073/pnas.2106041118
7T32ANucleotideAdenosineA2AHomo sapiensZM241385--3.42022-08-1010.1038/s41467-022-32125-2
8A2OANucleotideAdenosineA2AHomo sapiensTheophyllineNa-3.452023-08-3010.1107/S1600576723006428
8A2PANucleotideAdenosineA2AHomo sapiensLUAA47070Na-3.52023-08-3010.1107/S1600576723006428
8C9WANucleotideAdenosineA2AHomo sapiensEtrumadenant--2.112023-07-1210.1038/s42004-023-00894-6
8CICANucleotideAdenosineA2AHomo sapiensEtrumadenantNa-2.12023-05-3110.1038/s42004-023-00894-6
8CU6ANucleotideAdenosineA2AHomo sapiensLJ-4517--2.82022-08-3110.1021/acs.jmedchem.2c00462
8CU7ANucleotideAdenosineA2AHomo sapiensLJ-4517Na-2.052022-08-3110.1021/acs.jmedchem.2c00462
8DU3ANucleotideAdenosineA2AHomo sapiensPubChem 105526064--2.52022-08-1010.1016/j.ejmech.2022.114620
8FYNANucleotideAdenosineA2AHomo sapiensZM241385Na-22023-03-0810.1038/s41467-023-36733-4
8GNEANucleotideAdenosineA2AHomo sapiensKW-6356Na-2.32023-03-2210.1124/molpharm.122.000633
8GNGANucleotideAdenosineA2AHomo sapiensIstradefylline--3.22023-03-2210.1124/molpharm.122.000633
8JWYANucleotideAdenosineA2AHomo sapiensPubChem 168451710--2.332023-08-1610.1007/s11427-023-2459-8
8JWZANucleotideAdenosineA2AHomo sapiensAB928Na-2.372023-08-1610.1007/s11427-023-2459-8
8PWNANucleotideAdenosineA2AHomo sapiensTheophylline--2.752023-10-2510.1038/s42004-023-01014-0




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