CodeZMA
Name4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Synonyms4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Identifier4-[2-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-e][1,3,5]triazin-5-yl]amino]ethyl]phenol
FormulaC16 H15 N7 O2
Molecular Weight337.336
SMILESc1cc(oc1)c2nc3nc(nc(n3n2)N)NCCc4ccc(cc4)O
PubChem176407
Formal Charge0
Total Atoms40
Total Chiral Atoms0
Total Bonds43
Total Aromatic Bonds22
Networks30
 missing image

This ligand is also present in the following 30 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3EML A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 2.6 2008-10-14 10.1126/science.1164772

A 2D representation of the interactions of ZMA in 3EML
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:T88 R:R:W246 10.92 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 13.11 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 40.16 1 Yes Yes 0 4 0 1
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 7.71 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:M177 4.33 0 No Yes 4 6 2 1
R:R:M174 R:R:N253 8.41 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 4.65 1 No Yes 5 6 2 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 1 Yes No 6 5 1 2
R:R:F182 R:R:H250 21.5 1 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 1 Yes No 6 7 1 2
R:R:F242 R:R:W246 12.03 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 9.67 1 Yes No 9 9 2 2
R:R:H250 R:R:W246 3.17 1 Yes Yes 6 8 1 1
R:R:S277 R:R:W246 13.59 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 6.78 1 No Yes 9 8 2 1
L:L:?1 R:R:W246 3.68 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
L:L:?1 R:R:L249 16.11 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 4.99 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 10.65 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 9.58 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 6.57 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 5.82 1 Yes Yes 0 2 0 1
L:L:?1 R:R:L267 3.58 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 10.05 1 Yes No 0 4 0 1
R:R:H278 R:R:I274 3.98 4 Yes No 6 4 2 1
L:L:?1 R:R:I274 4.61 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 4 Yes No 6 7 2 2
R:R:A265 R:R:H264 2.93 0 No Yes 4 2 2 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.34
Average Nodes In Shell28.00
Average Hubs In Shell10.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3PWH A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 3.3 2011-09-07 10.1016/j.str.2011.06.014

A 2D representation of the interactions of ZMA in 3PWH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Y271 R:R:Y9 14.89 1 Yes No 3 5 1 2
R:R:E13 R:R:Y271 6.73 1 Yes Yes 6 3 2 1
R:R:E13 R:R:V275 5.7 1 Yes No 6 5 2 2
R:R:E13 R:R:H278 16 1 Yes Yes 6 6 2 2
L:L:?1 R:R:S67 13.59 1 Yes No 0 3 0 1
R:R:E169 R:R:L167 5.3 1 No No 3 4 1 2
R:R:D170 R:R:L167 5.43 1 No No 4 4 2 2
R:R:F168 R:R:V172 5.24 1 No No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 No No 4 6 1 1
L:L:?1 R:R:F168 36.22 1 Yes No 0 4 0 1
R:R:D170 R:R:E169 9.09 1 No No 4 3 2 1
L:L:?1 R:R:E169 3.43 1 Yes No 0 3 0 1
R:R:M177 R:R:Y176 3.59 1 No Yes 6 6 1 2
L:L:?1 R:R:M177 6.4 1 Yes No 0 6 0 1
R:R:I274 R:R:L249 5.71 1 No No 4 5 1 1
L:L:?1 R:R:L249 17 1 Yes No 0 5 0 1
L:L:?1 R:R:N253 10.65 1 Yes No 0 5 0 1
L:L:?1 R:R:M270 6.4 1 Yes No 0 4 0 1
R:R:V275 R:R:Y271 8.83 1 No Yes 5 3 2 1
L:L:?1 R:R:Y271 6.82 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 10.15 1 Yes No 0 4 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub1.00
Average Interaction Strength12.30
Average Nodes In Shell20.00
Average Hubs In Shell5.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3VG9 A Nucleotide Adenosine A2A Homo sapiens ZM241385 Antibody - 2.7 2012-02-01 10.1038/nature10750

A 2D representation of the interactions of ZMA in 3VG9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Y271 R:R:Y9 11.91 0 No Yes 3 5 1 2
R:R:S67 R:R:Y271 5.09 0 No No 3 3 2 1
R:R:F242 R:R:T88 3.89 6 Yes No 9 6 2 2
R:R:T88 R:R:W246 16.98 6 No Yes 6 8 2 1
R:R:F168 R:R:V172 26.22 0 No No 4 3 1 2
R:R:F168 R:R:M177 3.73 0 No No 4 6 1 2
L:L:?1 R:R:F168 37.01 6 Yes No 0 4 0 1
R:R:E169 R:R:H264 12.31 6 No No 3 2 1 1
L:L:?1 R:R:E169 11.14 6 Yes No 0 3 0 1
R:R:H250 R:R:N181 5.1 6 Yes No 6 5 1 2
R:R:F182 R:R:H250 26.02 0 Yes Yes 5 6 2 1
R:R:F242 R:R:W246 10.02 6 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 9.67 6 Yes No 9 9 2 2
R:R:H250 R:R:W246 3.17 6 Yes Yes 6 8 1 1
R:R:S277 R:R:W246 18.53 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 5.65 6 No Yes 9 8 2 1
L:L:?1 R:R:W246 5.89 6 Yes Yes 0 8 0 1
R:R:H250 R:R:L249 3.86 6 Yes Yes 6 5 1 1
R:R:L249 R:R:N253 5.49 6 Yes No 5 5 1 1
R:R:A273 R:R:L249 4.73 0 No Yes 6 5 2 1
L:L:?1 R:R:L249 13.42 6 Yes Yes 0 5 0 1
L:L:?1 R:R:H250 4.16 6 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 9.76 6 Yes No 0 5 0 1
R:R:H264 R:R:T256 6.85 6 No No 2 4 1 2
L:L:?1 R:R:H264 3.32 6 Yes No 0 2 0 1
R:R:A265 R:R:M270 3.22 0 No No 4 4 2 1
L:L:?1 R:R:M270 9.14 6 Yes No 0 4 0 1
L:L:?1 R:R:Y271 3.79 6 Yes No 0 3 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength10.85
Average Nodes In Shell24.00
Average Hubs In Shell7.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3VGA A Nucleotide Adenosine A2A Homo sapiens ZM241385 Antibody - 3.1 2012-02-01 10.1038/nature10750

A 2D representation of the interactions of ZMA in 3VGA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L85 R:R:Y176 3.52 0 No Yes 4 6 1 2
R:R:L85 R:R:N181 4.12 0 No No 4 5 1 2
L:L:?1 R:R:L85 3.58 5 Yes No 0 4 0 1
R:R:E169 R:R:F168 3.5 5 No Yes 3 4 1 1
R:R:F168 R:R:V172 13.11 5 Yes No 4 3 1 2
L:L:?1 R:R:F168 32.28 5 Yes Yes 0 4 0 1
R:R:E169 R:R:H264 3.69 5 No No 3 2 1 2
L:L:?1 R:R:E169 23.13 5 Yes No 0 3 0 1
R:R:M174 R:R:N253 8.41 0 No No 4 5 2 1
L:L:?1 R:R:M177 10.97 5 Yes No 0 6 0 1
R:R:F182 R:R:H250 31.68 0 Yes No 5 6 2 1
R:R:L249 R:R:W246 5.69 5 Yes Yes 5 8 1 2
R:R:S277 R:R:W246 13.59 5 No Yes 7 8 2 2
R:R:L249 R:R:N253 4.12 5 Yes No 5 5 1 1
R:R:L249 R:R:S277 3 5 Yes No 5 7 1 2
L:L:?1 R:R:L249 13.42 5 Yes Yes 0 5 0 1
L:L:?1 R:R:H250 3.32 5 Yes No 0 6 0 1
L:L:?1 R:R:N253 6.21 5 Yes No 0 5 0 1
L:L:?1 R:R:M270 5.48 5 Yes No 0 4 0 1
R:R:H278 R:R:I274 5.3 5 Yes No 6 4 2 1
L:L:?1 R:R:I274 3.69 5 Yes No 0 4 0 1
R:R:H278 R:R:S277 5.58 5 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength11.34
Average Nodes In Shell21.00
Average Hubs In Shell7.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4EIY A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 1.8 2012-07-25 10.1126/science.1219218

A 2D representation of the interactions of ZMA in 4EIY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 15.89 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:T88 R:R:W246 15.77 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 38.58 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 9.85 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 14.56 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 8.41 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 6.98 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 27.15 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:F242 R:R:W246 12.03 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 7.25 1 Yes No 9 9 2 2
R:R:S277 R:R:W246 12.36 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 3.39 1 No Yes 9 8 2 1
L:L:?1 R:R:W246 3.68 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 19.69 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 5.82 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 12.32 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 4.16 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 4.69 0 No Yes 3 3 2 1
L:L:?1 R:R:M270 9.14 1 Yes No 0 4 0 1
R:R:I274 R:R:Y271 3.63 1 No Yes 4 3 1 1
L:L:?1 R:R:Y271 4.55 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 5.54 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength11.32
Average Nodes In Shell30.00
Average Hubs In Shell13.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5IU4 A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 1.72 2016-06-29 10.1021/acs.jmedchem.6b00653

A 2D representation of the interactions of ZMA in 5IU4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 16.88 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?2 R:R:F168 38.58 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 9.85 1 No Yes 3 2 1 1
L:L:?2 R:R:E169 14.56 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 9.82 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 10.47 1 No Yes 5 6 2 2
L:L:?2 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 1 Yes No 6 5 1 2
R:R:F182 R:R:V186 3.93 1 Yes No 5 7 2 2
R:R:F182 R:R:H250 24.89 1 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 1 Yes No 6 7 1 2
R:R:H250 R:R:W246 3.17 1 Yes Yes 6 8 1 2
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
L:L:?2 R:R:L249 19.69 1 Yes No 0 5 0 1
L:L:?2 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?2 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 10.95 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?2 R:R:H264 4.16 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 7.03 0 No Yes 3 3 2 1
L:L:?2 R:R:M270 8.23 1 Yes No 0 4 0 1
L:L:?2 R:R:Y271 4.55 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?2 R:R:I274 5.54 1 Yes No 0 4 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength12.16
Average Nodes In Shell26.00
Average Hubs In Shell11.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5JTB A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 2.8 2017-05-31 10.1126/sciadv.1602952

A 2D representation of the interactions of ZMA in 5JTB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L85 R:R:M177 4.24 1 No Yes 4 6 2 1
R:R:L85 R:R:N181 8.24 1 No Yes 4 5 2 2
R:R:T88 R:R:W246 7.28 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 37.01 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 Yes Yes 3 4 1 2
R:R:E169 R:R:T256 5.64 1 Yes No 3 4 1 2
R:R:E169 R:R:H264 9.85 1 Yes Yes 3 2 1 1
L:L:?1 R:R:E169 13.71 1 Yes Yes 0 3 0 1
R:R:M174 R:R:N253 8.41 1 Yes No 4 5 2 1
R:R:M174 R:R:T256 4.52 1 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 3.49 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 5.61 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 1 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 24.89 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 1 Yes No 6 7 1 2
R:R:F242 R:R:W246 12.03 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 8.46 1 Yes Yes 9 9 2 2
R:R:H250 R:R:W246 3.17 1 Yes Yes 6 8 1 1
R:R:S277 R:R:W246 16.06 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 4.52 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W246 3.68 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
L:L:?1 R:R:L249 20.58 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 3.32 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 12.32 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 3.94 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 5.82 1 Yes Yes 0 2 0 1
L:L:?1 R:R:M270 10.05 1 Yes No 0 4 0 1
R:R:I274 R:R:Y271 3.63 0 No Yes 4 3 1 2
R:R:H278 R:R:I274 3.98 3 Yes No 6 4 2 1
L:L:?1 R:R:I274 5.54 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 3 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength11.85
Average Nodes In Shell28.00
Average Hubs In Shell15.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5K2A A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 2.5 2016-09-21 10.1126/sciadv.1600292

A 2D representation of the interactions of ZMA in 5K2A
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:T88 R:R:W246 12.13 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 11.8 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 33.07 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 12.85 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 4.65 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 5.48 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 23.76 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:F242 R:R:W246 11.02 0 Yes Yes 9 8 2 1
R:R:S277 R:R:W246 14.83 0 No Yes 7 8 2 1
L:L:?1 R:R:W246 3.68 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 20.58 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 7.48 1 Yes Yes 0 6 0 1
R:R:I252 R:R:M270 4.37 0 No No 5 4 2 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 8.21 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 4.69 0 No Yes 3 3 1 2
L:L:?1 R:R:L267 5.37 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 6.4 1 Yes No 0 4 0 1
R:R:I274 R:R:Y271 3.63 0 No Yes 4 3 1 2
R:R:H278 R:R:I274 3.98 3 Yes No 6 4 2 1
L:L:?1 R:R:I274 3.69 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 3 Yes No 6 7 2 2
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.40
Average Nodes In Shell27.00
Average Hubs In Shell12.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5K2B A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 2.5 2016-09-21 10.1126/sciadv.1600292

A 2D representation of the interactions of ZMA in 5K2B
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:T88 R:R:W246 12.13 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 7.87 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 8.71 1 Yes Yes 4 6 1 2
L:L:?1 R:R:F168 35.43 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 12.85 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 4.56 1 Yes No 6 3 2 2
R:R:M174 R:R:N253 5.61 0 No No 4 5 2 1
R:R:N181 R:R:V186 2.96 1 Yes No 5 7 2 2
R:R:H250 R:R:N181 3.83 1 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 22.63 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 1 Yes No 6 7 1 2
R:R:F242 R:R:W246 11.02 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 8.46 1 Yes No 9 9 2 2
R:R:S277 R:R:W246 14.83 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 4.52 1 No Yes 9 8 2 1
L:L:?1 R:R:W246 2.95 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No Yes 6 5 2 1
R:R:I274 R:R:L249 2.85 1 No Yes 4 5 1 1
R:R:L249 R:R:S277 3 1 Yes No 5 7 1 2
L:L:?1 R:R:L249 19.69 1 Yes Yes 0 5 0 1
L:L:?1 R:R:H250 6.65 1 Yes Yes 0 6 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 9.58 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 4.69 0 No No 3 3 1 2
L:L:?1 R:R:L267 3.58 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 6.4 1 Yes No 0 4 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 4.61 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.79
Average Nodes In Shell27.00
Average Hubs In Shell11.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5K2C A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 1.9 2016-09-21 10.1126/sciadv.1600292

A 2D representation of the interactions of ZMA in 5K2C
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 15.89 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:F168 R:R:V172 11.8 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 35.43 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 5.81 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 23.76 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 16.11 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 6.85 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 4.69 0 No Yes 3 3 2 1
L:L:?1 R:R:M270 9.14 1 Yes No 0 4 0 1
L:L:?1 R:R:Y271 3.03 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 4.61 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.17
Average Nodes In Shell26.00
Average Hubs In Shell10.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5K2D A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 1.9 2016-09-21 10.1126/sciadv.1600292

A 2D representation of the interactions of ZMA in 5K2D
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F168 R:R:V172 13.11 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 35.43 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 5.81 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 5.48 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 22.63 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 16.11 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 6.85 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
L:L:?1 R:R:M270 8.23 1 Yes No 0 4 0 1
R:R:H278 R:R:I274 3.98 2 Yes No 6 4 2 1
L:L:?1 R:R:I274 4.61 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 2 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.87
Average Nodes In Shell22.00
Average Hubs In Shell9.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5NLX A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 2.14 2017-09-27 10.1038/s41467-017-00630-4

A 2D representation of the interactions of ZMA in 5NLX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F168 R:R:V172 11.8 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?400 R:R:F168 39.37 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No No 3 4 1 2
R:R:E169 R:R:H264 9.85 1 No Yes 3 2 1 1
L:L:?400 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 5.61 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 8.14 1 Yes Yes 5 6 2 2
L:L:?400 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:N181 R:R:V186 2.96 1 Yes Yes 5 7 2 2
R:R:H250 R:R:N181 5.1 1 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 22.63 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 5.54 1 Yes Yes 6 7 1 2
R:R:A273 R:R:L249 4.73 0 No No 6 5 2 1
R:R:I274 R:R:L249 4.28 1 Yes No 4 5 1 1
L:L:?400 R:R:L249 19.69 1 Yes No 0 5 0 1
L:L:?400 R:R:H250 8.31 1 Yes Yes 0 6 0 1
L:L:?400 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 8.21 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?400 R:R:H264 4.16 1 Yes Yes 0 2 0 1
L:L:?400 R:R:L267 6.26 1 Yes No 0 3 0 1
L:L:?400 R:R:M270 7.31 1 Yes No 0 4 0 1
R:R:H278 R:R:I274 3.98 1 Yes Yes 6 4 2 1
L:L:?400 R:R:I274 3.69 1 Yes Yes 0 4 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
R:R:I274 R:R:Y271 2.42 1 Yes No 4 3 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength12.13
Average Nodes In Shell23.00
Average Hubs In Shell11.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5NM2 A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 1.95 2017-09-27 10.1038/s41467-017-00630-4

A 2D representation of the interactions of ZMA in 5NM2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No Yes 3 5 2 2
R:R:Y271 R:R:Y9 16.88 1 Yes Yes 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:C82 R:R:L85 3.17 0 No Yes 5 4 2 1
R:R:L85 R:R:V84 2.98 1 Yes No 4 6 1 2
R:R:L85 R:R:Y176 3.52 1 Yes Yes 4 6 1 2
R:R:L85 R:R:N181 8.24 1 Yes No 4 5 1 2
L:L:?2 R:R:L85 3.58 1 Yes Yes 0 4 0 1
R:R:F168 R:R:V172 11.8 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?2 R:R:F168 38.58 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?2 R:R:E169 14.56 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 9.82 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 9.3 1 No Yes 5 6 2 2
L:L:?2 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes No 6 5 1 2
R:R:F182 R:R:H250 24.89 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:F242 R:R:W246 17.04 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 8.46 1 Yes No 9 9 2 2
R:R:A277 R:R:W246 9.08 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 3.39 1 No Yes 9 8 2 1
L:L:?2 R:R:W246 3.68 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
L:L:?2 R:R:L249 19.69 1 Yes No 0 5 0 1
L:L:?2 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?2 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 12.32 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 6.57 1 Yes No 2 4 1 1
L:L:?2 R:R:H264 4.16 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 7.03 0 No Yes 3 3 2 1
L:L:?2 R:R:M270 9.14 1 Yes No 0 4 0 1
L:L:?2 R:R:Y271 4.55 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?2 R:R:I274 5.54 1 Yes No 0 4 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
R:R:A88 R:R:W246 2.59 0 No Yes 6 8 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.82
Average Nodes In Shell33.00
Average Hubs In Shell14.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5NM4 A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 1.7 2017-09-27 10.1038/s41467-017-00630-4

A 2D representation of the interactions of ZMA in 5NM4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y271 3.82 0 No No 3 3 2 1
R:R:L85 R:R:Y176 3.52 1 Yes Yes 4 6 2 2
R:R:L85 R:R:M177 4.24 1 Yes Yes 4 6 2 1
R:R:L85 R:R:N181 5.49 1 Yes No 4 5 2 2
R:R:F168 R:R:V172 11.8 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 39.37 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 9.82 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 4.52 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 8.14 1 No Yes 5 6 2 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 5.1 0 Yes No 6 5 1 2
R:R:F182 R:R:H250 22.63 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:H250 R:R:W246 3.17 0 Yes Yes 6 8 1 2
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:I274 R:R:L249 4.28 1 No No 4 5 1 1
L:L:?1 R:R:L249 20.58 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 6.65 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 10.95 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 5.86 0 No No 3 3 2 1
L:L:?1 R:R:M270 8.23 1 Yes No 0 4 0 1
L:L:?1 R:R:Y271 3.03 1 Yes No 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 3.69 1 Yes No 0 4 0 1
R:R:A265 R:R:H264 2.93 0 No Yes 4 2 2 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.74
Average Nodes In Shell27.00
Average Hubs In Shell11.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5OLG A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 1.87 2018-01-17 10.1038/s41598-017-18570-w

A 2D representation of the interactions of ZMA in 5OLG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 16.88 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:A88 R:R:W246 3.89 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 11.8 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes No 4 6 1 1
L:L:?1 R:R:F168 39.37 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 15.42 1 Yes No 0 3 0 1
R:R:M174 R:R:N253 8.41 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 No Yes 6 6 1 2
R:R:N181 R:R:Y176 11.63 1 No Yes 5 6 2 2
L:L:?1 R:R:M177 6.4 1 Yes No 0 6 0 1
R:R:H250 R:R:N181 3.83 1 Yes No 6 5 1 2
R:R:F182 R:R:V186 3.93 1 Yes Yes 5 7 2 2
R:R:F182 R:R:H250 26.02 1 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 1 Yes Yes 6 7 1 2
R:R:F242 R:R:W246 17.04 6 Yes Yes 9 8 2 1
R:R:A277 R:R:W246 7.78 0 No Yes 7 8 2 1
L:L:?1 R:R:W246 3.68 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L249 18.79 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 6.65 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 10.95 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 4.99 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 7.03 0 No Yes 3 3 2 1
L:L:?1 R:R:M270 9.14 1 Yes No 0 4 0 1
L:L:?1 R:R:Y271 3.79 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 5.54 1 Yes No 0 4 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.47
Average Nodes In Shell29.00
Average Hubs In Shell11.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5UVI A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 3.2 2017-05-24 10.1107/S205225251700570X

A 2D representation of the interactions of ZMA in 5UVI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L85 R:R:Y176 3.52 2 Yes Yes 4 6 2 2
R:R:L85 R:R:M177 2.83 2 Yes Yes 4 6 2 1
R:R:L85 R:R:N181 8.24 2 Yes No 4 5 2 2
R:R:T88 R:R:W246 10.92 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 3.93 0 No No 4 3 1 2
L:L:?1 R:R:F168 40.94 2 Yes No 0 4 0 1
R:R:E169 R:R:M174 6.77 2 Yes No 3 4 1 2
R:R:E169 R:R:T256 5.64 2 Yes No 3 4 1 2
R:R:E169 R:R:H264 11.08 2 Yes Yes 3 2 1 1
L:L:?1 R:R:E169 6 2 Yes Yes 0 3 0 1
R:R:M177 R:R:V172 3.04 2 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 2 Yes Yes 6 6 1 2
L:L:?1 R:R:M177 6.4 2 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes No 6 5 1 2
R:R:F182 R:R:H250 22.63 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:F242 R:R:W246 11.02 0 Yes Yes 9 8 2 1
R:R:S277 R:R:W246 14.83 0 No Yes 7 8 2 1
L:L:?1 R:R:W246 3.68 2 Yes Yes 0 8 0 1
R:R:I274 R:R:L249 2.85 0 No No 4 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 16.11 2 Yes No 0 5 0 1
L:L:?1 R:R:H250 5.82 2 Yes Yes 0 6 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
L:L:?1 R:R:N253 12.43 2 Yes No 0 5 0 1
R:R:H264 R:R:T256 9.58 2 Yes No 2 4 1 2
R:R:H264 R:R:M270 3.94 2 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 2 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 4.69 0 No Yes 3 3 1 2
L:L:?1 R:R:L267 6.26 2 Yes No 0 3 0 1
L:L:?1 R:R:M270 7.31 2 Yes No 0 4 0 1
R:R:I274 R:R:Y271 3.63 0 No Yes 4 3 2 2
R:R:A81 R:R:F168 2.77 0 No No 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.83
Average Nodes In Shell26.00
Average Hubs In Shell11.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5VRA A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 2.35 2017-12-13 10.1038/nprot.2017.135

A 2D representation of the interactions of ZMA in 5VRA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:T88 R:R:W246 10.92 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 37.79 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 8.62 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 15.42 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 8.41 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:F182 R:R:H250 27.15 0 Yes No 5 6 2 1
R:R:H250 R:R:V186 8.3 0 No No 6 7 1 2
R:R:F242 R:R:W246 11.02 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 8.46 1 Yes No 9 9 2 2
R:R:S277 R:R:W246 14.83 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 3.39 1 No Yes 9 8 2 1
L:L:?1 R:R:W246 5.15 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 20.58 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 7.48 1 Yes No 0 6 0 1
R:R:I252 R:R:M270 4.37 0 No No 5 4 2 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 9.58 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 4.16 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 5.86 0 No No 3 3 1 2
L:L:?1 R:R:L267 3.58 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 8.23 1 Yes No 0 4 0 1
R:R:H278 R:R:I274 3.98 3 Yes No 6 4 2 1
L:L:?1 R:R:I274 5.54 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 3 Yes No 6 7 2 2
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.52
Average Nodes In Shell27.00
Average Hubs In Shell10.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6AQF A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 2.51 2018-01-10 10.1016/j.cell.2017.12.004

A 2D representation of the interactions of ZMA in 6AQF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 14.89 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:L85 R:R:M177 4.24 1 No Yes 4 6 2 1
R:R:L85 R:R:N181 8.24 1 No No 4 5 2 2
R:R:F242 R:R:T88 3.89 1 Yes No 9 6 2 2
R:R:T88 R:R:W246 12.13 1 No Yes 6 8 2 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 37.01 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 Yes Yes 3 4 1 2
R:R:E169 R:R:T256 5.64 1 Yes No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 Yes No 3 2 1 2
L:L:?1 R:R:E169 12.85 1 Yes Yes 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 1 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 1 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 4.65 1 No Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes No 6 5 1 2
R:R:M177 R:R:N253 4.21 1 Yes No 6 5 1 1
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:F182 R:R:H250 19.23 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 1 Yes No 6 7 1 2
R:R:F242 R:R:W246 11.02 1 Yes Yes 9 8 2 1
R:R:H250 R:R:W246 3.17 1 Yes Yes 6 8 1 1
R:R:S277 R:R:W246 17.3 0 No Yes 7 8 2 1
L:L:?1 R:R:W246 4.42 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 18.79 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 5.82 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 9.58 1 No No 2 4 2 2
R:R:H264 R:R:M270 3.94 1 No No 2 4 2 1
R:R:A265 R:R:M270 3.22 0 No No 4 4 2 1
R:R:L267 R:R:Y271 4.69 0 No Yes 3 3 2 1
L:L:?1 R:R:M270 4.57 1 Yes No 0 4 0 1
L:L:?1 R:R:Y271 3.03 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 5.54 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength11.09
Average Nodes In Shell30.00
Average Hubs In Shell12.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6JZH A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 2.25 2019-10-30 10.1107/S1600576719012846

A 2D representation of the interactions of ZMA in 6JZH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F168 R:R:V172 11.8 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?2 R:R:F168 35.43 1 Yes Yes 0 4 0 1
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?2 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:M174 R:R:N253 7.01 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 4.65 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes Yes 6 5 1 2
L:L:?2 R:R:M177 5.48 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 26.02 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 8.3 0 Yes No 6 7 1 2
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
L:L:?2 R:R:L249 20.58 1 Yes No 0 5 0 1
L:L:?2 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?2 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 9.58 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?2 R:R:H264 3.32 1 Yes Yes 0 2 0 1
L:L:?2 R:R:M270 7.31 1 Yes No 0 4 0 1
R:R:H278 R:R:I274 3.98 2 Yes No 6 4 2 1
L:L:?2 R:R:I274 4.61 1 Yes No 0 4 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength12.26
Average Nodes In Shell21.00
Average Hubs In Shell9.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LPJ A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 1.8 2020-11-25 10.1038/s41598-020-76277-x

A 2D representation of the interactions of ZMA in 6LPJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 15.89 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 38.58 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 9.85 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 8.14 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 5.61 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 27.15 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:A273 R:R:L249 4.73 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 20.58 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 9.58 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 3.52 1 No Yes 3 3 1 1
L:L:?1 R:R:L267 6.26 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 9.14 1 Yes No 0 4 0 1
L:L:?1 R:R:Y271 3.79 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 6.46 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.65
Average Nodes In Shell26.00
Average Hubs In Shell11.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LPK A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 1.8 2020-11-25 10.1038/s41598-020-76277-x

A 2D representation of the interactions of ZMA in 6LPK
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 15.89 1 No No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No No 3 3 2 1
R:R:F168 R:R:V172 15.73 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 37.79 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 9.85 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 8.14 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 5.61 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 26.02 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 20.58 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 10.95 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
L:L:?1 R:R:L267 7.16 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 9.14 1 Yes No 0 4 0 1
L:L:?1 R:R:Y271 3.03 1 Yes No 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 6.46 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.59
Average Nodes In Shell26.00
Average Hubs In Shell10.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LPL A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 2 2020-11-25 10.1038/s41598-020-76277-x

A 2D representation of the interactions of ZMA in 6LPL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 15.89 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:T88 R:R:W246 15.77 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 39.37 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 14.56 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 4.52 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 9.3 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 5.61 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 1 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 28.28 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 1 Yes No 6 7 1 2
R:R:F242 R:R:W246 14.03 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 7.25 1 Yes No 9 9 2 2
R:R:H250 R:R:W246 3.17 1 Yes Yes 6 8 1 1
R:R:S277 R:R:W246 12.36 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 3.39 1 No Yes 9 8 2 1
L:L:?1 R:R:W246 3.68 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
L:L:?1 R:R:L249 18.79 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 5.82 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 12.32 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 3.52 1 No Yes 3 3 1 1
L:L:?1 R:R:L267 6.26 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 9.14 1 Yes No 0 4 0 1
L:L:?1 R:R:Y271 4.55 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 5.3 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 6.46 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.90
Average Nodes In Shell30.00
Average Hubs In Shell13.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6MH8 A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 4.2 2019-04-24 10.1107/S205225251900263X

A 2D representation of the interactions of ZMA in 6MH8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:G69 R:R:L167 3.42 0 No Yes 4 4 2 1
R:R:L85 R:R:Y176 3.52 1 Yes Yes 4 6 2 2
R:R:L85 R:R:M177 4.24 1 Yes Yes 4 6 2 1
R:R:T88 R:R:W246 13.34 0 No Yes 6 8 2 1
R:R:K153 R:R:L167 4.23 1 No Yes 4 4 2 1
R:R:D170 R:R:K153 6.91 1 No No 4 4 2 2
R:R:D170 R:R:L167 8.14 1 No Yes 4 4 2 1
R:R:F168 R:R:V172 17.04 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 31.5 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 Yes No 3 4 1 2
R:R:E169 R:R:T256 7.06 1 Yes No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 Yes No 3 2 1 2
L:L:?1 R:R:E169 10.28 1 Yes Yes 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 5.61 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
L:L:?1 R:R:M177 3.66 1 Yes Yes 0 6 0 1
R:R:F242 R:R:W246 18.04 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 8.46 1 Yes No 9 9 2 2
R:R:S277 R:R:W246 11.12 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 3.39 1 No Yes 9 8 2 1
L:L:?1 R:R:W246 2.95 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 10.74 1 Yes No 0 5 0 1
R:R:I252 R:R:M270 4.37 0 No No 5 4 2 1
L:L:?1 R:R:N253 10.65 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 9.58 1 No No 2 4 2 2
R:R:H264 R:R:M270 5.25 1 No No 2 4 2 1
R:R:L267 R:R:Y271 4.69 0 No No 3 3 1 2
L:L:?1 R:R:L267 5.37 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 4.57 1 Yes No 0 4 0 1
R:R:H278 R:R:I274 6.63 2 Yes No 6 4 2 1
L:L:?1 R:R:I274 6.46 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 2 Yes No 6 7 2 2
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
L:L:?1 R:R:L167 2.68 1 Yes Yes 0 4 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.89
Average Nodes In Shell29.00
Average Hubs In Shell10.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6PS7 A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 1.85 2019-11-13 10.1107/S2052252519013137

A 2D representation of the interactions of ZMA in 6PS7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F168 R:R:V172 13.11 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 37.01 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 9.85 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 8.41 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 5.81 1 No Yes 5 6 2 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes No 6 5 1 2
R:R:F182 R:R:H250 23.76 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?1 R:R:L249 20.58 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 4.99 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 10.95 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
L:L:?1 R:R:M270 8.23 1 Yes No 0 4 0 1
R:R:H278 R:R:I274 3.98 2 Yes No 6 4 2 1
L:L:?1 R:R:I274 4.61 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 2 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength12.36
Average Nodes In Shell21.00
Average Hubs In Shell9.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6S0L A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 2.65 2020-07-15 10.1107/S2052252520011379

A 2D representation of the interactions of ZMA in 6S0L
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F168 R:R:V172 7.87 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 40.94 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 Yes Yes 3 4 1 2
R:R:E169 R:R:T256 5.64 1 Yes No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 Yes Yes 3 2 1 1
L:L:?1 R:R:E169 12.85 1 Yes Yes 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 4.21 1 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 1 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 10.47 0 No Yes 5 6 2 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes No 6 5 1 2
R:R:F182 R:R:H250 21.5 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:F242 R:R:W246 13.03 0 Yes Yes 9 8 2 1
R:R:A277 R:R:W246 9.08 0 No Yes 7 8 2 1
L:L:?1 R:R:W246 4.42 1 Yes Yes 0 8 0 1
R:R:L249 R:R:N253 4.12 1 No No 5 5 1 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
L:L:?1 R:R:L249 18.79 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 11.54 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 10.95 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 6.57 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 3.32 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 5.86 0 No No 3 3 1 2
L:L:?1 R:R:L267 5.37 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 9.14 1 Yes No 0 4 0 1
R:R:H278 R:R:I274 3.98 3 Yes No 6 4 2 1
L:L:?1 R:R:I274 3.69 1 Yes No 0 4 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
R:R:A88 R:R:W246 2.59 0 No Yes 6 8 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength11.27
Average Nodes In Shell27.00
Average Hubs In Shell12.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6S0Q A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 2.65 2020-07-15 10.1107/S2052252520011379

A 2D representation of the interactions of ZMA in 6S0Q
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 3.82 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 15.89 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 5.09 1 No Yes 3 3 2 1
R:R:F168 R:R:V172 11.8 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 39.37 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No No 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 4.21 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 9.3 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes Yes 6 5 1 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 22.63 5 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 0 Yes No 6 7 1 2
R:R:F242 R:R:W246 13.03 0 Yes Yes 9 8 2 1
R:R:A277 R:R:W246 7.78 0 No Yes 7 8 2 1
L:L:?1 R:R:W246 3.68 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 4.73 0 No No 6 5 2 1
L:L:?1 R:R:L249 15.21 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 6.65 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 11.54 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 12.32 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 4.16 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 5.86 1 No Yes 3 3 1 1
L:L:?1 R:R:L267 5.37 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 10.97 1 Yes No 0 4 0 1
L:L:?1 R:R:Y271 3.03 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 5.3 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 3.69 1 Yes No 0 4 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
R:R:A88 R:R:W246 2.59 0 No Yes 6 8 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.31
Average Nodes In Shell29.00
Average Hubs In Shell12.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6WQA A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 2 2020-11-18 10.1107/S2052252520012701

A 2D representation of the interactions of ZMA in 6WQA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 15.89 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:L85 R:R:Y176 3.52 1 Yes Yes 4 6 2 2
R:R:L85 R:R:M177 4.24 1 Yes Yes 4 6 2 1
R:R:L85 R:R:N181 6.87 1 Yes Yes 4 5 2 2
R:R:T88 R:R:W246 14.55 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 13.11 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?2 R:R:F168 35.43 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?2 R:R:E169 12.85 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 7.01 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 5.81 1 Yes Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes Yes 6 5 1 2
R:R:M177 R:R:N253 4.21 1 Yes No 6 5 1 1
L:L:?2 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 5.1 0 Yes Yes 6 5 1 2
R:R:F182 R:R:H250 23.76 0 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 8.3 0 Yes No 6 7 1 2
R:R:F242 R:R:W246 12.03 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 7.25 1 Yes Yes 9 9 2 2
R:R:S277 R:R:W246 12.36 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 4.52 1 Yes Yes 9 8 2 1
L:L:?2 R:R:W246 2.95 1 Yes Yes 0 8 0 1
R:R:L249 R:R:S277 3 0 No No 5 7 1 2
L:L:?2 R:R:L249 19.69 1 Yes No 0 5 0 1
L:L:?2 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?2 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 9.58 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 3.94 1 Yes No 2 4 1 1
L:L:?2 R:R:H264 3.32 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 4.69 1 No Yes 3 3 1 1
L:L:?2 R:R:L267 3.58 1 Yes No 0 3 0 1
L:L:?2 R:R:M270 8.23 1 Yes No 0 4 0 1
L:L:?2 R:R:Y271 3.03 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?2 R:R:I274 3.69 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.92
Average Nodes In Shell30.00
Average Hubs In Shell15.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell42.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RM5 A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 2.79 2021-09-08 10.1073/pnas.2106041118

A 2D representation of the interactions of ZMA in 7RM5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 6.36 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 14.89 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 8.9 1 No Yes 3 3 2 1
R:R:T88 R:R:W246 4.85 0 No Yes 6 8 2 1
R:R:F168 R:R:V172 7.87 1 Yes Yes 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 37.79 1 Yes Yes 0 4 0 1
R:R:E169 R:R:H264 8.62 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 13.71 1 Yes No 0 3 0 1
R:R:V172 R:R:Y176 3.79 1 Yes Yes 3 6 2 2
R:R:M174 R:R:N253 4.21 0 No No 4 5 2 1
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:M177 R:R:N181 4.21 1 Yes No 6 5 1 2
L:L:?1 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 5.1 1 Yes No 6 5 1 2
R:R:F182 R:R:V186 3.93 1 Yes No 5 7 2 2
R:R:F182 R:R:H250 23.76 1 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 4.15 1 Yes No 6 7 1 2
R:R:F242 R:R:W246 11.02 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 8.46 1 Yes Yes 9 9 2 2
R:R:S277 R:R:W246 14.83 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 6.78 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W246 4.42 1 Yes Yes 0 8 0 1
R:R:A273 R:R:L249 4.73 0 No No 6 5 2 1
L:L:?1 R:R:L249 19.69 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 8.31 1 Yes Yes 0 6 0 1
L:L:?1 R:R:N253 10.65 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 6.85 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 9.19 1 Yes No 2 4 1 1
L:L:?1 R:R:H264 4.16 1 Yes Yes 0 2 0 1
R:R:A265 R:R:M270 3.22 0 No No 4 4 2 1
L:L:?1 R:R:L267 7.16 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 8.23 1 Yes No 0 4 0 1
R:R:I274 R:R:Y271 3.63 1 No Yes 4 3 1 1
L:L:?1 R:R:Y271 3.79 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?1 R:R:I274 7.38 1 Yes No 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
R:R:F168 R:R:I66 2.51 1 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.97
Average Nodes In Shell31.00
Average Hubs In Shell13.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7T32 A Nucleotide Adenosine A2A Homo sapiens ZM241385 - - 3.4 2022-08-10 10.1038/s41467-022-32125-2

A 2D representation of the interactions of ZMA in 7T32
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Y271 R:R:Y9 17.87 0 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 0 No Yes 3 3 2 1
R:R:L85 R:R:N181 5.49 0 No No 4 5 1 2
L:L:?1 R:R:L85 5.37 0 Yes No 0 4 0 1
R:R:T88 R:R:W246 19.41 0 No Yes 6 8 2 1
R:R:E169 R:R:L167 7.95 2 No No 3 4 1 2
R:R:D170 R:R:L167 6.79 2 No No 4 4 2 2
R:R:F168 R:R:V172 9.18 7 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 7 Yes No 4 6 1 2
L:L:?1 R:R:F168 35.43 0 Yes Yes 0 4 0 1
R:R:D170 R:R:E169 3.9 2 No No 4 3 2 1
L:L:?1 R:R:E169 15.42 0 Yes No 0 3 0 1
R:R:M177 R:R:V172 4.56 7 No No 6 3 2 2
R:R:F182 R:R:H250 11.31 8 No No 5 6 2 1
R:R:F242 R:R:W246 10.02 4 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 6.04 4 Yes No 9 9 2 2
R:R:S277 R:R:W246 18.53 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 3.39 4 No Yes 9 8 2 1
L:L:?1 R:R:W246 3.68 0 Yes Yes 0 8 0 1
L:L:?1 R:R:L249 8.95 0 Yes No 0 5 0 1
L:L:?1 R:R:H250 5.82 0 Yes No 0 6 0 1
L:L:?1 R:R:H264 8.31 0 Yes No 0 2 0 1
R:R:A265 R:R:M270 3.22 0 Yes No 4 4 2 1
R:R:L267 R:R:Y271 10.55 0 No Yes 3 3 2 1
L:L:?1 R:R:M270 6.4 0 Yes No 0 4 0 1
L:L:?1 R:R:Y271 4.55 0 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 0 No No 6 4 2 1
L:L:?1 R:R:I274 6.46 0 Yes No 0 4 0 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
R:R:V84 R:R:W246 2.45 0 No Yes 6 8 2 1
R:R:A273 R:R:L249 1.58 0 No No 6 5 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength10.04
Average Nodes In Shell29.00
Average Hubs In Shell6.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FYN A Nucleotide Adenosine A2A Homo sapiens ZM241385 Na - 2 2023-03-08 10.1038/s41467-023-36733-4

A 2D representation of the interactions of ZMA in 8FYN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No Yes 3 5 2 2
R:R:Y271 R:R:Y9 15.89 1 Yes Yes 3 5 1 2
R:R:I274 R:R:Y9 3.63 1 Yes Yes 4 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:L85 R:R:M177 4.24 1 No Yes 4 6 2 1
R:R:L85 R:R:N181 12.36 1 No No 4 5 2 2
R:R:F242 R:R:T88 3.89 1 Yes No 9 6 2 2
R:R:T88 R:R:W246 13.34 1 No Yes 6 8 2 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 6.22 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F168 40.16 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 6.77 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 11.08 1 No Yes 3 2 1 1
L:L:?1 R:R:E169 14.56 1 Yes No 0 3 0 1
R:R:M174 R:R:N253 5.61 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 4.52 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 11.63 1 No Yes 5 6 2 2
R:R:M177 R:R:N181 4.21 1 Yes No 6 5 1 2
L:L:?1 R:R:M177 5.48 1 Yes Yes 0 6 0 1
R:R:F182 R:R:H250 27.15 0 No No 5 6 2 1
R:R:H250 R:R:V186 9.69 0 No No 6 7 1 2
R:R:F242 R:R:W246 14.03 1 Yes Yes 9 8 2 1
R:R:F242 R:R:N280 8.46 1 Yes Yes 9 9 2 2
R:R:S277 R:R:W246 12.36 0 No Yes 7 8 2 1
R:R:N280 R:R:W246 4.52 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W246 4.42 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L249 22.37 1 Yes No 0 5 0 1
L:L:?1 R:R:H250 5.82 1 Yes No 0 6 0 1
L:L:?1 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 10.95 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 6.57 1 Yes Yes 2 4 1 1
L:L:?1 R:R:H264 4.16 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 5.86 1 No Yes 3 3 1 1
L:L:?1 R:R:L267 4.47 1 Yes No 0 3 0 1
L:L:?1 R:R:M270 6.4 1 Yes Yes 0 4 0 1
R:R:I274 R:R:Y271 3.63 1 Yes Yes 4 3 1 1
L:L:?1 R:R:Y271 3.79 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes Yes 6 4 2 1
L:L:?1 R:R:I274 5.54 1 Yes Yes 0 4 0 1
R:R:H278 R:R:S277 4.18 1 Yes No 6 7 2 2
R:R:A265 R:R:M270 3.22 0 No Yes 4 4 2 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:I252 R:R:M270 2.92 0 No Yes 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.80
Average Nodes In Shell32.00
Average Hubs In Shell14.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.47
Average Number Of Links With An Hub4.83
Average Interaction Strength11.17
Average Nodes In Shell26.83
Average Hubs In Shell10.80
Average Links In Shell35.17
Average Links Mediated by Hubs In Shell30.53

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)