Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:E13 10.325416
2R:R:I16 3.03417
3R:R:N24 7.3525409
4R:R:N34 8.28426
5R:R:L37 7.8025428
6R:R:N42 7.015428
7R:R:F44 5.535407
8R:R:V55 5.1775406
9R:R:I60 5.505616
10R:R:F62 6.455445
11R:R:F70 5.4025407
12R:R:F79 4.6925444
13R:R:F83 5.498545
14R:R:Q89 7.13455
15R:R:F93 6.105455
16R:R:R102 6.4575439
17R:R:I104 3.4475435
18R:R:I106 4.6125408
19R:R:Y112 6.79833637
20R:R:V116 6.5575437
21R:R:T138 3.4775416
22R:R:W143 9.3225415
23R:R:C146 6.7925481
24R:R:K153 5.3725464
25R:R:Q157 3.4473
26R:R:C159 4.2475473
27R:R:F168 15.8075414
28R:R:P173 4.848514
29R:R:M174 6.425404
30R:R:Y176 8.2425816
31R:R:M177 5.1225416
32R:R:F182 8.512515
33R:R:F183 4.695414
34R:R:Y197 5.4425409
35R:R:F242 7.79167619
36R:R:W246 7.054518
37R:R:H250 9.258516
38R:R:F257 8.565413
39R:R:F258 6.08416
40R:R:H264 7.5525412
41R:R:L269 4.5675494
42R:R:Y271 8.07413
43R:R:H278 8.095416
44R:R:Y288 5.706529
45R:R:E294 6.2425426
46R:R:F295 6.65333628
47L:L:?2 12.1621010
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F83 R:R:L87 37.31598.53YesNo057
2R:R:L87 R:R:V55 38.81074.47NoYes076
3R:R:I60 R:R:V55 22.24043.07YesYes066
4R:R:N24 R:R:P285 50.60759.77YesNo099
5R:R:D52 R:R:N24 10012.12NoYes099
6R:R:D52 R:R:S281 46.384411.78NoNo099
7R:R:S281 R:R:V55 43.6588.08NoYes096
8R:R:A49 R:R:N24 49.82334.69NoYes099
9R:R:F295 R:R:Y288 55.53395.16YesYes289
10R:R:V27 R:R:Y288 99.10713.79NoYes099
11R:R:A49 R:R:V27 49.56923.39NoNo099
12R:R:P285 R:R:V27 50.09943.53NoNo099
13R:R:V45 R:R:Y288 37.761410.09NoYes089
14R:R:N42 R:R:V45 37.11344.43YesNo088
15R:R:F295 R:R:N42 37.95297.25YesYes288
16R:R:N39 R:R:N42 74.95412.26NoYes078
17R:R:N39 R:R:T41 73.42974.39NoNo078
18R:R:D101 R:R:T41 35.206210.12NoNo398
19R:R:D101 R:R:Y112 33.777611.49NoYes397
20R:R:V116 R:R:Y112 35.320313.88YesYes377
21R:R:V116 R:R:V40 29.01514.81YesNo076
22R:R:V40 R:R:Y43 22.79452.52NoNo065
23R:R:R102 R:R:T41 36.68819.06YesNo398
24R:R:R102 R:R:Y112 33.63033.09YesYes397
25R:R:F44 R:R:I125 22.03616.28YesNo078
26R:R:I125 R:R:S47 22.80746.19NoNo089
27R:R:S47 R:R:S94 33.21983.26NoNo097
28R:R:L48 R:R:S94 33.93594.5NoNo097
29R:R:L48 R:R:S91 34.64843NoNo099
30I:I:?1 R:R:S91 28.7395.94NoNo109
31I:I:?1 R:R:D52 69.29318.05NoNo009
32R:R:F44 R:R:I98 19.69263.77YesNo078
33R:R:S47 R:R:W129 11.03096.18NoNo099
34R:R:F62 R:R:F83 29.16976.43YesYes455
35R:R:F62 R:R:I80 28.83111.3YesNo056
36R:R:C166 R:R:F70 17.52036.98NoYes097
37R:R:C166 R:R:I66 27.22943.27NoNo094
38R:R:I66 R:R:I80 28.0322.94NoNo046
39R:R:F70 R:R:T68 14.97973.89YesNo075
40R:R:G69 R:R:T68 14.12371.82NoNo045
41R:R:G69 R:R:L167 13.2643.42NoNo044
42R:R:K153 R:R:L167 10.69044.23YesNo644
43R:R:H250 R:R:N181 12.33983.83YesNo165
44L:L:?2 R:R:H250 19.22867.48YesYes106
45L:L:?2 R:R:I274 11.61085.54YesNo004
46R:R:H278 R:R:I274 12.00113.98YesNo064
47R:R:H250 R:R:W246 39.4793.17YesYes168
48R:R:F242 R:R:W246 40.491517.04YesYes198
49I:I:?1 R:R:F242 40.13994.82NoYes109
50R:R:I104 R:R:Y112 25.87444.84YesYes357
51R:R:I100 R:R:I104 13.04682.94NoYes065
52R:R:A99 R:R:Y197 12.59026.67NoYes099
53R:R:A235 R:R:Y197 18.16274NoYes089
54R:R:A235 R:R:I98 18.90461.62NoNo088
55R:R:A99 R:R:V196 11.7713.39NoNo097
56R:R:I200 R:R:V196 10.94813.07NoNo097
57R:R:G118 R:R:Y43 13.04682.9NoNo015
58R:R:F182 R:R:H250 11.767324.89YesYes156
59R:R:H278 R:R:I60 11.973511.93YesYes166
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 5.09 1 No No 3 5 2 2
R:R:Y271 R:R:Y9 16.88 1 Yes No 3 5 1 2
R:R:S67 R:R:Y271 3.82 1 No Yes 3 3 2 1
R:R:F168 R:R:V172 14.42 1 Yes No 4 3 1 2
R:R:F168 R:R:M177 7.46 1 Yes Yes 4 6 1 1
L:L:?2 R:R:F168 38.58 1 Yes Yes 0 4 0 1
R:R:E169 R:R:M174 5.41 1 No Yes 3 4 1 2
R:R:E169 R:R:H264 9.85 1 No Yes 3 2 1 1
L:L:?2 R:R:E169 14.56 1 Yes No 0 3 0 1
R:R:M177 R:R:V172 3.04 1 Yes No 6 3 1 2
R:R:M174 R:R:N253 9.82 0 Yes No 4 5 2 1
R:R:M174 R:R:T256 3.01 0 Yes No 4 4 2 2
R:R:M177 R:R:Y176 3.59 1 Yes Yes 6 6 1 2
R:R:N181 R:R:Y176 10.47 1 No Yes 5 6 2 2
L:L:?2 R:R:M177 6.4 1 Yes Yes 0 6 0 1
R:R:H250 R:R:N181 3.83 1 Yes No 6 5 1 2
R:R:F182 R:R:V186 3.93 1 Yes No 5 7 2 2
R:R:F182 R:R:H250 24.89 1 Yes Yes 5 6 2 1
R:R:H250 R:R:V186 6.92 1 Yes No 6 7 1 2
R:R:H250 R:R:W246 3.17 1 Yes Yes 6 8 1 2
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
L:L:?2 R:R:L249 19.69 1 Yes No 0 5 0 1
L:L:?2 R:R:H250 7.48 1 Yes Yes 0 6 0 1
L:L:?2 R:R:N253 12.43 1 Yes No 0 5 0 1
R:R:H264 R:R:T256 10.95 1 Yes No 2 4 1 2
R:R:H264 R:R:M270 5.25 1 Yes No 2 4 1 1
L:L:?2 R:R:H264 4.16 1 Yes Yes 0 2 0 1
R:R:L267 R:R:Y271 7.03 0 No Yes 3 3 2 1
L:L:?2 R:R:M270 8.23 1 Yes No 0 4 0 1
L:L:?2 R:R:Y271 4.55 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 1 Yes No 6 4 2 1
L:L:?2 R:R:I274 5.54 1 Yes No 0 4 0 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:A81 R:R:F168 2.77 0 No Yes 5 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
100.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
100.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
90.91Single4EIYZM2413854EIY-A2A-ZM241385-Na
90.91Single5IU8Q274563475IU8-A2A-Q27456347-Na
90.91Single5OLGZM2413855OLG-A2A-ZM241385-Na
90.91Single6LPJZM2413856LPJ-A2A-ZM241385-Na
90.91Single6LPKZM2413856LPK-A2A-ZM241385-Na
90.91Single7PYRPSB-21157PYR-A2A-PSB-2115
90.91Consensusa2_offOrthosteric Liganda2a_off
90.91Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
90.00Single5K2DZM2413855K2D-A2A-ZM241385
90.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
90.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
83.33Single5IUAQ274563485IUA-A2A-Q27456348-Na
83.33Single5NM2ZM2413855NM2-A2A-ZM241385-Na
83.33Single6LPLZM2413856LPL-A2A-ZM241385-Na
83.33Single6S0QZM2413856S0Q-A2A-ZM241385
83.33Single6WQAZM2413856WQA-A2A-ZM241385-Na
83.33Single7RM5ZM2413857RM5-A2A-ZM241385-Na
83.33Single8FYNZM2413858FYN-A2A-ZM241385-Na
81.82Single5IU7Q274563465IU7-A2A-Q27456346-Na
81.82Single5JTBZM2413855JTB-A2A-ZM241385
81.82Single5NLXZM2413855NLX-A2A-ZM241385-Na
81.82Single6AQFZM2413856AQF-A2A-ZM241385
81.82Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
76.92Single7PX4PSB-21137PX4-A2A-PSB-2113
76.92Consensusadenosine_offOrthosteric Liganda1_off a2_off
75.00Single3EMLZM2413853EML-A2A-ZM241385
75.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
75.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
75.00Single6S0LZM2413856S0L-A2A-ZM241385
72.73Single3PWHZM2413853PWH-A2A-ZM241385
72.73Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
72.73Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
72.73Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
72.73Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
72.73Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
72.73Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
69.23Single8GNEKW-63568GNE-A2A-KW-6356-Na
66.67Single3REYPubChem 56973REY-A2A-PubChem 5697
66.67Single5K2BZM2413855K2B-A2A-ZM241385-Na
66.67Single5UVIZM2413855UVI-A2A-ZM241385
66.67Single7AROLUF58337ARO-A2A-LUF5833-Na
66.67Single7T32ZM2413857T32-A2A-ZM241385
61.54Single5UENDU1725UEN-A1-DU172
61.54Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
61.54Single8CU6LJ-45178CU6-A2A-LJ-4517
61.54Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
60.00Single3RFMCaffeine3RFM-A2A-Caffeine
60.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
58.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
57.14Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
57.14Single5N2SPSB365N2S-A1-PSB36
57.14Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
57.14Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
57.14Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
57.14Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
56.25Single7EZCUKA7EZC-A2A-UKA
55.56Single3QAKUK-4320973QAK-A2A-UK-432097
54.55Single3UZAGTPL92363UZA-A2A-GTPL9236
53.85Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
53.85Single6MH8ZM2413856MH8-A2A-ZM241385
53.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
53.33Consensusa2_onOrthosteric Liganda2a_on a2b_on
53.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
52.94Single5WF6UK-4320975WF6-A2A-UK-432097
50.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
50.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
50.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
50.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
50.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
50.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
50.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
50.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
50.00Single8PWNTheophylline8PWN-A2A-Theophylline
50.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
50.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
50.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
50.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
50.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
47.06Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
46.67Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.67Single8QOTNanobody E8QOT-μ-Nanobody E
46.67Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.15Single7F8ULintitript7F8U-CCKA-Lintitript
46.15Single8GNGIstradefylline8GNG-A2A-Istradefylline
45.00Single5WF5UK-4320975WF5-A2A-UK-432097
44.44Single3NY9PubChem 9131033NY9-β2-PubChem 913103
44.44Single4UG2CGS216804UG2-A2A-CGS21680
44.44Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
44.44Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
43.75Single3P0GBI1671073P0G-β2-BI167107
43.75Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
43.75Single7TUYGSK682753A7TUY-GPR183-GSK682753A
43.75Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
43.75Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.75Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
43.75Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
43.75Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
43.75Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
42.11Single7F8XNN90567F8X-CCKA-NN9056
41.18Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
41.18Single6MXTSalmeterol6MXT-β2-Salmeterol
41.18Single8JJ8Formoterol8JJ8-β2-Formoterol
41.18Single8JJLOlodaterol8JJL-β2-Olodaterol
41.18Single8JWZAB9288JWZ-A2A-AB928-Na
40.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
40.00Single6PS1Timolol6PS1-β2-Timolol
40.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
40.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
40.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
40.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
40.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
38.89Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.89Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
38.89Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
38.89Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
38.89Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
38.89Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
38.89Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
38.46Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
38.46Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
38.10Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
37.50Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
37.50Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
37.50Single6E67BI1671076E67-β2-BI167107-Gs (fused)
37.50Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
37.50Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
37.50Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
37.50Single7XKAEpinephrine7XKA-β2-Epinephrine
37.50Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
37.50Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
37.50Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
37.50Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
37.50Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
37.50Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
37.50Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
37.50Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
36.84Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
36.84Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
36.84Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.36Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
36.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
35.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
35.71Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.71Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
35.71Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
35.71Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Single2YDVNECA2YDV-A2A-NECA
35.29Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
35.29Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
35.29Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
35.29Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
35.29Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
35.29Single4UHRCGS216804UHR-A2A-CGS21680
35.29Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
35.29Single5G53NECA5G53-A2A-NECA-Gs
35.29Single5V56TC1145V56-SMO-TC114
35.29Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
35.29Single6J21Aprepitant6J21-NK1-Aprepitant
35.29Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
35.29Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
35.29Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
35.29Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
35.29Single7W41PD1762527W41-BB2-PD176252
35.29Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
35.29Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
35.29Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
35.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
35.29Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
35.29Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
35.29Consensus5ht5_offOrthosteric Ligand5ht5a_off
35.29Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
35.29Consensusbombesin_offOrthosteric Ligandbb2_off
35.29Consensuscck_onOrthosteric Ligandccka_on cckb_on
35.29Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
35.29Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
35.29Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
35.29Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
35.29Consensuslpa_offOrthosteric Ligandlpa1_off
35.29Consensuslpa_onOrthosteric Ligandlpa1_on
35.29Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
35.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
35.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
35.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
35.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
34.78Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
34.78Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
34.78Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
34.78Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
34.78Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
33.33Single2YDOAdenosine2YDO-A2A-Adenosine
33.33Single4LDEBI1671074LDE-β2-BI167107
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
33.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
33.33Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
33.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
33.33Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
33.33Single6HLOAprepitant6HLO-NK1-Aprepitant
33.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
33.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
33.33Single6PS4ICI 118-5516PS4-β2-ICI 118-551
33.33Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
33.33Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
33.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
33.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
33.33Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
33.33Single7YITNalfurafine7YIT-κ-Nalfurafine
33.33Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGKEpinephrine8GGK-β2-Epinephrine
33.33Single8GGMEpinephrine8GGM-β2-Epinephrine
33.33Single8GGPEpinephrine8GGP-β2-Epinephrine
33.33Single8GGQEpinephrine8GGQ-β2-Epinephrine
33.33Single8GGTEpinephrine8GGT-β2-Epinephrine
33.33Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
33.33Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
33.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
33.33Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
33.33Consensusdp_offOrthosteric Liganddp2_off
33.33Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
33.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
33.33Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
33.33Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
33.33Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
33.33Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
33.33Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
32.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
31.82Single6PT2KGCHM076PT2-δ-KGCHM07
31.82Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
31.82Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
31.82Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
31.58Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
31.58Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
31.58Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.58Single6H7LDobutamine6H7L-β1-Dobutamine
31.58Single6IBLArformoterol6IBL-β1-Arformoterol
31.58Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
31.58Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Single7UM4AS26747237UM4-5-HT5A-AS2674723
31.58Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
31.58Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
31.58Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
31.58Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
31.58Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
31.58Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
31.58Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
31.58Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
31.58Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
31.25Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
31.25Single2Y01Dobutamine2Y01-β1-Dobutamine
31.25Single2Y02Carmoterol2Y02-β1-Carmoterol
31.25Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
31.25Single3NY8ICI 118-5513NY8-β2-ICI 118-551
31.25Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
31.25Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
31.25Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
31.25Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
31.25Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
31.25Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
31.25Single6D27CAY104716D27-DP2-CAY10471
31.25Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
31.25Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
31.25Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
31.25Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
31.25Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
31.25Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.25Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.25Single7BU7BI1671077BU7-β1-BI167107
31.25Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.25Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
31.25Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
31.25Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
31.25Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
31.25Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
31.25Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
31.25Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
31.25Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
31.25Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
31.25Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GGJEpinephrine8GGJ-β2-Epinephrine
31.25Single8GGNEpinephrine8GGN-β2-Epinephrine
31.25Single8GGOEpinephrine8GGO-β2-Epinephrine
31.25Single8GGUEpinephrine8GGU-β2-Epinephrine
31.25Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
31.25Single8JJOAlprenolol8JJO-β2-Alprenolol
31.25Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
31.25Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
31.25Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
31.25Consensuscck_offOrthosteric Ligandccka_off
31.25Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
31.25Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
31.25Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
30.77Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
30.77Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
30.77Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.77Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
30.77Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.77Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
30.77Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.43Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
30.43Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
30.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
30.43Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
30.43Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
30.00Single6PT3DPI-2876PT3-δ-DPI-287
30.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
30.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
30.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7XN9L-054,5227XN9-SST2-L-054,522
30.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
30.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
30.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
30.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
30.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
30.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
30.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
30.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
30.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.63Single5GLHEndothelin-15GLH-ETB-Endothelin-1
29.63Single6IGKEndothelin-36IGK-ETB-Endothelin-3
29.41Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
29.41Single2Y00Dobutamine2Y00-β1-Dobutamine
29.41Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
29.41Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
29.41Single5C1MBU725C1M-μ-BU72
29.41Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
29.41Single5TVNLSD5TVN-5-HT2B-LSD
29.41Single6D26Fevipiprant6D26-DP2-Fevipiprant
29.41Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
29.41Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
29.41Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
29.41Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
29.41Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
29.41Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
29.41Single6PS6Timolol6PS6-β2-Timolol
29.41Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
29.41Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
29.41Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7WC6LSD7WC6-5-HT2A-LSD
29.41Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
29.41Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
29.41Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
29.41Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
29.41Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
29.41Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
29.41Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
29.41Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
29.41Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
29.41Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
29.41Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
29.17Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
29.17Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
29.17Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
29.17Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
29.17Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single3PBLEticlopride3PBL-D3-Eticlopride
28.57Single5L7IVismodegib5L7I-SMO-Vismodegib
28.57Single6HLLCP999946HLL-NK1-CP99994
28.57Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
28.57Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
28.57Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
28.57Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.57Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
28.57Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
28.57Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
28.57Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
28.57Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
28.57Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
28.57Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
28.57Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
28.57Single8GGSEpinephrine8GGS-β2-Epinephrine
28.57Single8GGYEpinephrine8GGY-β2-Epinephrine
28.57Single8GH1Epinephrine8GH1-β2-Epinephrine
28.57Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.57Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
28.57Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
28.57Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
28.57Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
28.57Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
28.57Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
28.57Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
28.57Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
28.57Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
28.57Consensussst_onOrthosteric Ligandsst2_on sst4_on
28.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
28.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
28.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
28.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
28.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
27.78Single4RWADIPP-NH24RWA-δ-DIPP-NH2
27.78Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
27.78Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
27.78Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
27.78Single5V57TC1145V57-SMO-TC114
27.78Single6H7JIsoprenaline6H7J-β1-Isoprenaline
27.78Single6J20Aprepitant6J20-NK1-Aprepitant
27.78Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
27.78Single6WGTLSD6WGT-5-HT2A-LSD
27.78Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
27.78Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
27.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
27.78Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
27.78Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
27.78Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
27.78Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
27.78Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
27.78Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
27.78Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
27.78Single8E0GBU728E0G-μ-BU72
27.78Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
27.78Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
27.78Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
27.78Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
27.78Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
27.78Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
27.78Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
27.78Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
27.78Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
27.78Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
27.78Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
27.78Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
27.78Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
27.78Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
27.78Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
27.78Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
27.78Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
27.78Consensusrelaxin_onOrthosteric Ligandrxfp4_on
27.78Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
27.59Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
27.27Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
27.27Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.27Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
27.27Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
27.27Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
27.27Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
27.27Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.92Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
26.92Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
26.92Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.67Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
26.67Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
26.67Single6KUXRS-799486KUX-α2a-RS-79948
26.67Single6ME2Ramelteon6ME2-MT1-Ramelteon
26.67Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
26.67Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
26.67Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
26.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
26.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
26.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
26.67Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
26.67Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
26.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
26.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
26.67Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
26.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
26.67Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GGVEpinephrine8GGV-β2-Epinephrine
26.67Single8GGXEpinephrine8GGX-β2-Epinephrine
26.67Single8GH0Epinephrine8GH0-β2-Epinephrine
26.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
26.67Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
26.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
26.67Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
26.67Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
26.67Consensusclass-f_offOrthosteric Ligandsmo_off
26.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
26.67Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
26.67Consensusmglu_onOther Ligandmglu2_on mglu4_on
26.67Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
26.32Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
26.32Single4AMIBucindolol4AMI-β1-Bucindolol
26.32Single4N4WSANT-14N4W-SMO-SANT-1
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4XEENeurotensin4XEE-NTS1-Neurotensin
26.32Single4XESNeurotensin4XES-NTS1-Neurotensin
26.32Single6A93Risperidone6A93-5-HT2A-Risperidone
26.32Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
26.32Single6CM4Risperidone6CM4-D2-Risperidone
26.32Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
26.32Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
26.32Single6OS2TRV0266OS2-AT1-TRV026
26.32Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.32Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
26.32Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.32Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
26.32Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
26.32Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
26.32Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
26.32Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
26.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.32Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
26.32Single8WU1KCA8WU1-CB1-KCA-Arrestin1
26.32Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
26.32Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
26.32Consensusclass-b2_onOrthosteric Ligandadgrg_on
26.32Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
26.32Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.32Consensusgs_steroidOrthosteric Ligandgs_bileacid
26.32Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.32Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
26.32Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
26.32Consensusnts_onOrthosteric Ligandnts1_on
26.32Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
26.09Single3OE0CVX153OE0-CXCR4-CVX15
26.09Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
26.09Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
26.09Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
26.09Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
26.09Consensusangiotensin_onOrthosteric Ligandat1_on
26.09Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.09Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
26.09Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
26.09Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
26.09Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single6IGLIRL16206IGL-ETB-IRL1620
25.93Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.93Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.93Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
25.93Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
25.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
25.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
25.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
25.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
25.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
25.00Single6TPGEMPA6TPG-OX2-EMPA
25.00Single6V9SGTPL114036V9S-OX1-GTPL11403
25.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
25.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
25.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
25.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
25.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
25.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
25.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
25.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
25.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
25.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
25.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
25.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
25.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Single7VV6C48/807VV6-MRGPRX2-C48/80
25.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
25.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
25.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
25.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGIEpinephrine8GGI-β2-Epinephrine
25.00Single8GGLEpinephrine8GGL-β2-Epinephrine
25.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
25.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
25.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
25.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
25.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
25.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
25.00Single8K5CAcipimox8K5C-HCA2-Acipimox
25.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
25.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
25.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
25.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
25.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
25.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
25.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
25.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
25.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
25.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
25.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
25.00Consensushcar_onOrthosteric Ligandhca_on
25.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
25.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensussteroid_onOrthosteric Ligandbileacid_on
24.14Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
24.14Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
24.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.81Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
23.81Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
23.81Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
23.81Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
23.81Single8X5YAstemizole8X5Y-H1-Astemizole
23.81Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
23.81Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.81Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single2Y04Salbutamol2Y04-β1-Salbutamol
23.53Single4EJ4Naltrindole4EJ4-δ-Naltrindole
23.53Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.53Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
23.53Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
23.53Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
23.53Single6H7MSalbutamol6H7M-β1-Salbutamol
23.53Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
23.53Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
23.53Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
23.53Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.53Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
23.53Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
23.53Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.53Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
23.53Single7UL4Alvimopan7UL4-μ-Alvimopan
23.53Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
23.53Single7WC7Lisuride7WC7-5-HT2A-Lisuride
23.53Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
23.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
23.53Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
23.53Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.53Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
23.53Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
23.53Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
23.53Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
23.53Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
23.53Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
23.53Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
23.53Single8X63Mepyramine8X63-H1-Mepyramine
23.53Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
23.53Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
23.53Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
23.53Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
23.53Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
23.53Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
23.53Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.53Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
23.53Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
23.53Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
23.53Consensustachykinin_offOrthosteric Ligandnk1_off
23.53Consensustar_onOrthosteric Ligandta1_on
23.08Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
23.08Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.08Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
23.08Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
23.08Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
22.73Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
22.73Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
22.73Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
22.73Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
22.73Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
22.73Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
22.73Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
22.73Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
22.73Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
22.73Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
22.73Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.58Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
22.58Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.58Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
22.22Single2Y03Isoprenaline2Y03-β1-Isoprenaline
22.22Single4NTJAZD12834NTJ-P2Y12-AZD1283
22.22Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
22.22Single5WQCEMPA5WQC-OX2-EMPA
22.22Single5XPRBosentan5XPR-ETB-Bosentan
22.22Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
22.22Single6LUQHaloperidol6LUQ-D2-Haloperidol
22.22Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.22Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
22.22Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
22.22Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
22.22Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
22.22Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
22.22Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
22.22Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
22.22Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
22.22Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
22.22Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
22.22Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.22Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
22.22Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
22.22Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
22.22Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
22.22Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
22.22Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
22.22Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
22.22Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
22.22Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
22.22Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
22.22Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
22.22Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
22.22Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
22.22Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
22.22Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
21.88Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
21.74Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
21.74Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
21.74Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.74Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
21.74Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
21.74Single7SK5CXCL127SK5-ACKR3-CXCL12
21.74Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
21.74Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.74Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
21.74Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
21.74Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
21.43Single4XNWMRS25004XNW-P2Y1-MRS2500
21.43Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.43Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.43Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
21.43Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
21.43Single6LI0GTPL98046LI0-GPR52-GTPL9804
21.43Single6ME5Agomelatine6ME5-MT1-Agomelatine
21.43Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.43Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
21.43Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
21.43Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
21.43Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.43Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single8GGREpinephrine8GGR-β2-Epinephrine
21.43Single8GGZEpinephrine8GGZ-β2-Epinephrine
21.43Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
21.43Single8IY6Endothelin-18IY6-ETB-Endothelin-1
21.43Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
21.43Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.43Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
21.05Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
21.05Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
21.05Single4BV0Neurotensin4BV0-NTS1-Neurotensin
21.05Single5TZR-5TZR-FFA1 (GPR40)-MK8666
21.05Single5V54Methiothepin5V54-5-HT1B-Methiothepin
21.05Single5X93K-87945X93-ETB-K-8794
21.05Single5XRAAM115425XRA-CB1-AM11542
21.05Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
21.05Single6E59L-7607356E59-NK1-L-760735
21.05Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
21.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.05Single6TQ7SB-3348676TQ7-OX1-SB-334867
21.05Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
21.05Single7B6WCyclazosin7B6W-α1b-Cyclazosin
21.05Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
21.05Single7F1TMIP-1a7F1T-CCR5-MIP-1a
21.05Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
21.05Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
21.05Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
21.05Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
21.05Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.05Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
21.05Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
21.05Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.05Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
21.05Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
21.05Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.05Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
21.05Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
21.05Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
21.05Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
21.05Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
21.05Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
21.05Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
21.05Consensus5ht1_offOrthosteric Ligand5ht1b_off
21.05Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
21.05Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
21.05Consensuschemerin_onOrthosteric Ligandcml1_on
21.05Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.05Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.05Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
21.05Consensushistamine_offOrthosteric Ligandh1_off
20.83Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.83Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.83Single6W25SHU91196W25-MC4-SHU9119-Ca
20.83Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
20.83Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7XNACYN1548067XNA-SST2-CYN154806
20.83Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
20.83Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
20.00Single3OE9IT1t3OE9-CXCR4-IT1t
20.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
20.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
20.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
20.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
20.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
20.00Single6HLPNetupitant6HLP-NK1-Netupitant
20.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
20.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
20.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
20.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
20.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
20.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
20.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
20.00Single7K15MKD0467K15-BLT1-MKD046-Na
20.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7SRQLSD7SRQ-5-HT2B-LSD
20.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
20.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
20.00Single7UL2SR486927UL2-NTS1-SR48692-Na
20.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
20.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
20.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
20.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
20.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
20.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
20.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
20.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
20.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
20.00Consensusgi_class-fOther Ligandgi_frizzled
20.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
20.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
20.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
20.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
20.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
20.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
20.00Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
20.00Consensusnts_offOrthosteric Ligandnts1_off
20.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
20.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.35Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
19.35Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
19.23Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
19.23Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
19.23Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
19.23Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
19.23Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
19.23Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
19.23Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
19.05Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
19.05Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
19.05Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
19.05Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
19.05Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.05Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
19.05Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
19.05Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
19.05Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
19.05Consensusendothelin_offOrthosteric Ligandetb_off
19.05Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
19.05Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.05Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
18.92Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
18.75Single4BWBNeurotensin4BWB-NTS1-Neurotensin
18.75Single4QINSAG1.54QIN-SMO-SAG1.5
18.75Single4S0VSuvorexant4S0V-OX2-Suvorexant
18.75Single5WS3EMPA5WS3-OX2-EMPA
18.75Single5ZKQABT-4915ZKQ-PAF-ABT-491
18.75Single6AKXA4R6AKX-CCR5-A4R
18.75Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
18.75Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
18.75Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
18.75Single6TODEMPA6TOD-OX1-EMPA-Na
18.75Single6TPJSuvorexant6TPJ-OX2-Suvorexant
18.75Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
18.75Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
18.75Single7BR3Elagolix7BR3-GnRH1-Elagolix
18.75Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
18.75Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
18.75Single7F8YDevazepide7F8Y-CCKA-Devazepide
18.75Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
18.75Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.75Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
18.75Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
18.75Single7XRRLemborexant7XRR-OX2-Lemborexant
18.75Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
18.75Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
18.75Single8GGWEpinephrine8GGW-β2-Epinephrine
18.75Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
18.75Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.75Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8IWESpermidine8IWE-TAAR9-Spermidine
18.75Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.75Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
18.75Consensusalpha1_onOrthosteric Ligandalpha1a_on
18.75Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
18.75Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
18.75Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Consensusgt_class-aOrthosteric Ligandgt_opsin
18.75Consensusgt_opsinOrthosteric Ligandgt_sensory
18.75Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
18.75Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
18.75Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
18.75Consensusorexin_offOrthosteric Ligandox2_off ox1_off
18.52Single4XT3Fractalkine4XT3-US28-Fractalkine
18.52Single6FJ3PTH6FJ3-PTH1-PTH
18.52Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.52Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7SK3CXCL127SK3-ACKR3-CXCL12
18.52Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
18.52Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
18.52Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
18.52Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.18Single5EE7MK08935EE7-Glucagon-MK0893
18.18Single5ZTYAM102575ZTY-CB2-AM10257
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
18.18Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7SK9CCX6627SK9-ACKR3-CCX662
18.18Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
18.18Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
18.18Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
18.18Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusgs_class-b2Orthosteric Ligandgs_adgr
18.18Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
17.86Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.86Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
17.86Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
17.86Consensusgo_class-b1Orthosteric Ligandgo_crf
17.86Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.65Single3RZECidoxepin3RZE-H1-Cidoxepin
17.65Single4MBSMaraviroc4MBS-CCR5-Maraviroc
17.65Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
17.65Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
17.65Single4ZJCSB-6740424ZJC-OX1-SB-674042
17.65Single6A94Zotepine6A94-5-HT2A-Zotepine
17.65Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
17.65Single6IQLL7458706IQL-D4-L745870
17.65Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
17.65Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
17.65Single6TP3Nemorexant6TP3-OX1-Nemorexant
17.65Single6TPKRetosiban6TPK-OT-Retosiban
17.65Single6TPNHTL66416TPN-OX2-HTL6641
17.65Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
17.65Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.65Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
17.65Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
17.65Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
17.65Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
17.65Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
17.65Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
17.65Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
17.65Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
17.65Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
17.65Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
17.65Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
17.65Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.65Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
17.65Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
17.65Single8K2WAMG4878K2W-CXCR3-AMG487
17.65Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
17.65Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.65Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
17.65Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
17.65Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
17.65Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
17.65Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
17.65Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
17.65Consensusgi_class-fOrthosteric Ligandgi_frizzled
17.65Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.65Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
17.65Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
17.65Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
17.65Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
17.65Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
17.65Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
17.65Consensussensory_offOrthosteric Ligandopsin_off
17.65Consensusvasopressin-ot_offOrthosteric Ligandot_off
17.39Single4XT1Fractalkine4XT1-US28-Fractalkine
17.39Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
17.24Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.24Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.24Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
17.24Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.24Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.67Single4DAJTiotropium4DAJ-M3-Tiotropium
16.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
16.67Single4MQSIperoxo4MQS-M2-Iperoxo
16.67Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
16.67Single4U14Tiotropium4U14-M3-Tiotropium
16.67Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
16.67Single5DSGTiotropium5DSG-M4-Tiotropium
16.67Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
16.67Single5TGZAM65385TGZ-CB1-AM6538
16.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.67Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
16.67Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
16.67Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
16.67Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
16.67Single6DRXLisuride6DRX-5-HT2B-Lisuride
16.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
16.67Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single6TOTLemborexant6TOT-OX1-Lemborexant
16.67Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
16.67Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
16.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
16.67Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
16.67Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
16.67Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
16.67Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
16.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
16.67Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
16.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.67Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.67Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
16.67Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
16.67Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
16.67Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
16.67Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
16.67Single8X64Desloratadine8X64-H1-Desloratadine
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
16.67Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
16.67Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
16.67Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
16.67Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
16.67Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Consensusgi_hcarOrthosteric Ligandgi_hca
16.67Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
16.67Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
16.67Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
16.67Consensushistamine_onOrthosteric Ligandh1_on h4_on
16.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
16.67Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
16.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
16.67Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
16.67Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
16.67Consensussst_offOrthosteric Ligandsst2_off
16.13Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
16.13Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.13Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
16.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
16.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.79Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
15.79Single5WIUNemonapride5WIU-D4-Nemonapride
15.79Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.79Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.79Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.79Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.79Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.79Single6TP6Filorexant6TP6-OX1-Filorexant
15.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.79Single6Z4SSR486926Z4S-NTS1-SR48692
15.79Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
15.79Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
15.79Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.79Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
15.79Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.79Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8EA0Iperoxo8EA0-M3-Iperoxo
15.79Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
15.79Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
15.79Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.79Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
15.79Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
15.79Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
15.79Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
15.79Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.79Consensusep_offOrthosteric Ligandep4_off
15.79Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.79Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
15.79Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.62Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.62Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.38Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
15.38Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
15.38Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.38Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
15.38Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
15.38Consensusclass-c_onOther Ligandgabab_on mglu_on
15.15Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.15Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.15Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
15.15Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.00Single4U15Tiotropium4U15-M3-Tiotropium
15.00Single5XR8AM8415XR8-CB1-AM841
15.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
15.00Single6OL9Tiotropium6OL9-M5-Tiotropium
15.00Single6OS1TRV0266OS1-AT1-TRV026
15.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
15.00Single7EPENAM5637EPE-mGlu-NAM563
15.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
15.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
15.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
15.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
15.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
15.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
15.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
15.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
15.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
15.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
15.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
15.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
15.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
15.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
14.81Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
14.81Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.81Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.81Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.81Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.71Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
14.29Single4PY02MeSATP4PY0-P2Y12-2MeSATP
14.29Single5CXVTiotropium5CXV-M1-Tiotropium
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
14.29Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
14.29Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.29Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single7DFPSpiperone7DFP-D2-Spiperone
14.29Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.29Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
14.29Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
14.29Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
14.29Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
14.29Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
14.29Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
14.29Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
14.29Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
14.29Consensusclass-d_onOrthosteric Ligandste2_on
14.29Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.29Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
14.29Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
14.29Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
14.29Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
14.29Consensussensory_onOrthosteric Ligandopsin_on
13.89Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.79Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.79Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
13.79Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.79Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
13.79Consensusgi_class-dOrthosteric Ligandgi_ste
13.79Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.64Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
13.64Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
13.64Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
13.64Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
13.64Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.64Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
13.64Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
13.64Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
13.64Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
13.64Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
13.64Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
13.64Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
13.64Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.64Consensuscyslt_offOrthosteric Ligandcyslt2_off
13.64Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.64Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
13.64Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.51Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.51Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
13.33Single3OE6IT1t3OE6-CXCR4-IT1t
13.33Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
13.33Single6LMLGlucagon6LML-Glucagon-Glucagon
13.33Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
13.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
13.33Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
13.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
13.33Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
13.33Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
13.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
13.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
13.33Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
13.33Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
13.33Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.33Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.33Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.33Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
13.33Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.04Single6KNMJN241-96KNM-Apelin-JN241-9
13.04Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
13.04Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.04Consensusclass-d_offOrthosteric Ligandste2_off
13.04Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
13.04Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.90Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.90Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
12.50Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
12.50Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
12.50Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
12.50Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
12.50Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.50Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
12.50Single7QA8Peptide7QA8-STE2-Peptide
12.50Single7QA8Peptide7QA8-STE2-Peptide
12.50Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
12.50Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
12.50Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
12.50Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.50Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
12.50Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
12.50Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
12.50Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
12.50Consensusclass-d_offOrthosteric Ligandste2_off
12.50Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.50Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Consensusgo_class-b2Orthosteric Ligandgo_adhesion
12.50Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
12.50Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.12Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
12.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
12.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.76Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.76Single3ODUIT1t3ODU-CXCR4-IT1t
11.76Single5DHHSB-6121115DHH-NOP-SB-612111
11.76Single5U09Taranabant5U09-CB1-Taranabant
11.76Single6AKYMaraviroc6AKY-CCR5-Maraviroc
11.76Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.76Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
11.76Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
11.76Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.76Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.76Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.76Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
11.76Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
11.76Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
11.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.76Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.76Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
11.76Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
11.76Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.76Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.76Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.54Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.54Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
11.54Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
11.11Single6VI4JDTic6VI4-κ-JDTic
11.11Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.11Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.11Single6ZINSR486926ZIN-NTS1-SR48692
11.11Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
11.11Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
11.11Single7VODCariprazine7VOD-5-HT2A-Cariprazine
11.11Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.11Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
11.11Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
11.11Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.11Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
11.11Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.11Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
11.11Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Consensusclass-d_onOrthosteric Ligandste2_on
11.11Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.11Consensusgi_class-dOrthosteric Ligandgi_ste
11.11Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
11.11Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
11.11Consensuss1p_offOrthosteric Ligands1p1_off
11.11Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
10.81Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.71Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.71Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.53Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.53Single4YAYZD-71554YAY-AT1-ZD-7155
10.53Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
10.53Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
10.53Single5T04Neurotensin5T04-NTS1-Neurotensin
10.53Single6GPSMK08126GPS-CCR2-MK0812
10.53Single6IIVDaltroban6IIV-TP-Daltroban
10.53Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.53Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.53Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
10.53Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.53Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
10.53Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
10.53Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
10.53Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.53Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
10.53Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
10.53Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
10.53Single8K5DGSK2560738K5D-HCA2-GSK256073
10.53Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
10.53Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.53Consensusblt_onOrthosteric Ligandblt1_on
10.53Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
10.53Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.53Consensusleuko_onOrthosteric Ligandblt_on
10.53Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.53Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
10.53Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
10.26Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
10.00Single5CGCHTL142425CGC-mGlu5-HTL14242
10.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00Single6GPXMK08126GPX-CCR2-MK0812
10.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
10.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
10.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
10.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
10.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
10.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.00Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
10.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
10.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.68Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
9.68Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.52Single4DJHJDTic4DJH-κ-JDTic
9.52Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
9.52Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.52Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
9.52Single7P2L4YI7P2L-mGlu5-4YI
9.52Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
9.52Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.52Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
9.52Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
9.52Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
9.52Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.09Single5X33BIIL2605X33-BLT1-BIIL260
9.09Single6IIURamatroban6IIU-TP-Ramatroban
9.09Single6ZG4HTL00099366ZG4-M1-HTL0009936
9.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.09Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
9.09Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
9.09Consensuschemokine_offOrthosteric Ligandcxcr_off
9.09Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
9.09Consensuscxcr_offOrthosteric Ligandcxcr4_off
9.09Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.70Single5CGDHTL142425CGD-mGlu5-HTL14242
8.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.70Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
8.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
7.69Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
7.69Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.69Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
7.14Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
7.14Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
7.14Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.14Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
6.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.67Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.67Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
6.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
6.45Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.25Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.25Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
6.25Single3OE8IT1t3OE8-CXCR4-IT1t
6.25Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.25Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
6.25Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.25Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
6.25Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
6.25Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.25Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
5.88Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
5.88Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.88Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.88Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.88Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
5.88Consensusclass-t_onOrthosteric Ligandtaste2_on
5.88Consensusgs_class-tOrthosteric Ligandgs_taste
5.88Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
5.56Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
5.56Single6B73PubChem 1319551386B73-κ-PubChem 131955138
5.56Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.56Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
5.56Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
5.56Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
5.56Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single8IHKAcifran8IHK-HCA3-Acifran
5.26Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
5.26Single6FFIMMPEP6FFI-mGlu5-MMPEP
5.26Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
5.26Single6ZG9GSK10347026ZG9-M1-GSK1034702
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
5.26Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
5.26Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.00Single6FFHFenobam6FFH-mGlu5-Fenobam
5.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
5.00Consensushcar_offOrthosteric Ligandsuccinate_off
5.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.88Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Single7C4SS1P7C4S-S1P3-S1P
4.76Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
4.76Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
4.55Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.55Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.55Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.17Single6K1QIRL25006K1Q-ETB-IRL2500
4.17Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
3.85Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.70Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
3.03Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.94Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.94Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.94Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.94Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.86Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.70Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.56Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.38Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.27Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 5IU4
Class A
SubFamily Nucleotide
Type Adenosine
SubType A2A
Species Homo sapiens
Ligand ZM241385
Other Ligand(s) Na
Protein Partners -
PDB Resolution 1.72
Date 2016-06-29
D.O.I. 10.1021/acs.jmedchem.6b00653
Net Summary
Imin 3
Number of Linked Nodes 274
Number of Links 320
Number of Hubs 47
Number of Links mediated by Hubs 173
Number of Communities 9
Number of Nodes involved in Communities 84
Number of Links involved in Communities 116
Path Summary
Number Of Nodes in MetaPath 60
Number Of Links MetaPath 59
Number of Shortest Paths 81352
Length Of Smallest Path 3
Average Path Length 17.6066
Length of Longest Path 37
Minimum Path Strength 1.17
Average Path Strength 6.69458
Maximum Path Strength 23.65
Minimum Path Correlation 0.7
Average Path Correlation 0.925177
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 41.7956
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.5807
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeZMA
PDB ResiduesL:L:?2
Environment DetailsOpen EMBL-EBI Page
CodeZMA
Name4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Synonyms4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Identifier4-[2-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-e][1,3,5]triazin-5-yl]amino]ethyl]phenol
FormulaC16 H15 N7 O2
Molecular Weight337.336
SMILESc1cc(oc1)c2nc3nc(nc(n3n2)N)NCCc4ccc(cc4)O
PubChem176407
Formal Charge0
Total Atoms40
Total Chiral Atoms0
Total Bonds43
Total Aromatic Bonds22

CodeNA
PDB ResiduesI:I:?1
Environment DetailsOpen EMBL-EBI Page
CodeNA
NameSODIUM ION
Synonyms
Identifiersodium(+1) cation
FormulaNa
Molecular Weight22.99
SMILES[Na+]
PubChem
Formal Charge1
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP29274
Sequence
>5IU4_Chain_R
PPIMGSSVY ITVELAIAV LAILGNVLV CWAVWLNSN LQNVTNYFV 
VSLAAADIL VGVLAIPFA ITISTGFCA ACHGCLFIA CFVLVLAQS 
SIFSLLAIA IDRYIAIAI PLRYNGLVT GTRAAGIIA ICWVLSFAI 
GLTPMLGWN NCGQPKEGK AHSQGCGEG QVACLFEDV VPMNYMVYF 
NFFACVLVP LLLMLGVYL RIFAAARRQ LERARSTLQ KEVHAAKSA 
AIIAGLFAL CWLPLHIIN CFTFFCPDC SHAPLWLMY LAIVLAHTN 
SVVNPFIYA YRIREFRQT FRKIIRS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2YDOANucleotideAdenosineA2AHomo sapiensAdenosine--32011-05-1810.1038/nature10136
2YDVANucleotideAdenosineA2AHomo sapiensNECA--2.62011-05-1810.1038/nature10136
3EMLANucleotideAdenosineA2AHomo sapiensZM241385--2.62008-10-1410.1126/science.1164772
3PWHANucleotideAdenosineA2AHomo sapiensZM241385--3.32011-09-0710.1016/j.str.2011.06.014
3QAKANucleotideAdenosineA2AHomo sapiensUK-432097--2.712011-03-0910.1126/science.1202793
3REYANucleotideAdenosineA2AHomo sapiensPubChem 5697--3.312011-09-0710.1016/j.str.2011.06.014
3RFMANucleotideAdenosineA2AHomo sapiensCaffeine--3.62011-09-0710.1016/j.str.2011.06.014
3UZAANucleotideAdenosineA2AHomo sapiensGTPL9236--3.272012-03-2110.1021/jm201376w
3UZCANucleotideAdenosineA2AHomo sapiensPubChem 135566609--3.342012-03-2110.1021/jm201376w
3VG9ANucleotideAdenosineA2AHomo sapiensZM241385Antibody-2.72012-02-0110.1038/nature10750
3VGAANucleotideAdenosineA2AHomo sapiensZM241385Antibody-3.12012-02-0110.1038/nature10750
4EIYANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82012-07-2510.1126/science.1219218
4UG2ANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
4UHRANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
5G53ANucleotideAdenosineA2AHomo sapiensNECA-Gs3.42016-08-0310.1038/nature18966
5IU7ANucleotideAdenosineA2AHomo sapiensQ27456346Na-1.92016-06-2910.1021/acs.jmedchem.6b00653
5IU8ANucleotideAdenosineA2AHomo sapiensQ27456347Na-22016-06-2910.1021/acs.jmedchem.6b00653
5IUAANucleotideAdenosineA2AHomo sapiensQ27456348Na-2.22016-06-2910.1021/acs.jmedchem.6b00653
5IUBANucleotideAdenosineA2AHomo sapiensQ27456344Na-2.12016-06-2910.1021/acs.jmedchem.6b00653
5JTBANucleotideAdenosineA2AHomo sapiensZM241385--2.82017-05-3110.1126/sciadv.1602952
5K2AANucleotideAdenosineA2AHomo sapiensZM241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2BANucleotideAdenosineA2AHomo sapiensZM241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2CANucleotideAdenosineA2AHomo sapiensZM241385Na-1.92016-09-2110.1126/sciadv.1600292
5K2DANucleotideAdenosineA2AHomo sapiensZM241385--1.92016-09-2110.1126/sciadv.1600292
5MZJANucleotideAdenosineA2AHomo sapiensTheophyllineNa-22017-07-2610.1016/j.str.2017.06.012
5MZPANucleotideAdenosineA2AHomo sapiensCaffeineNa-2.12017-07-2610.1016/j.str.2017.06.012
5N2RANucleotideAdenosineA2AHomo sapiensPubChem 92460631; psb36Na-2.82017-07-2610.1016/j.str.2017.06.012
5NLXANucleotideAdenosineA2AHomo sapiensZM241385Na-2.142017-09-2710.1038/s41467-017-00630-4
5NM2ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.952017-09-2710.1038/s41467-017-00630-4
5NM4ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.72017-09-2710.1038/s41467-017-00630-4
5OLGANucleotideAdenosineA2AHomo sapiensZM241385Na-1.872018-01-1710.1038/s41598-017-18570-w
5OLHANucleotideAdenosineA2AHomo sapiensVipadenantNa-2.62018-01-1710.1038/s41598-017-18570-w
5OLOANucleotideAdenosineA2AHomo sapiensTozadenantNa-3.12018-01-1710.1038/s41598-017-18570-w
5OLVANucleotideAdenosineA2AHomo sapiensLUAA41063Na-22018-01-1710.1038/s41598-017-18570-w
5OLZANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-1.92018-01-1710.1038/s41598-017-18570-w
5OM1ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-2.12018-01-1710.1038/s41598-017-18570-w
5OM4ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-22018-01-1710.1038/s41598-017-18570-w
5UIGANucleotideAdenosineA2AHomo sapiensJ3.651.884G--3.52017-02-0810.1073/pnas.1621423114
5UVIANucleotideAdenosineA2AHomo sapiensZM241385--3.22017-05-2410.1107/S205225251700570X
5VRAANucleotideAdenosineA2AHomo sapiensZM241385Na-2.352017-12-1310.1038/nprot.2017.135
5WF5ANucleotideAdenosineA2AHomo sapiensUK-432097--2.62018-02-2110.1016/j.str.2017.12.013
5WF6ANucleotideAdenosineA2AHomo sapiensUK-432097--2.92018-02-2110.1016/j.str.2017.12.013
6AQFANucleotideAdenosineA2AHomo sapiensZM241385--2.512018-01-1010.1016/j.cell.2017.12.004
6GDGANucleotideAdenosineA2AHomo sapiensNECA-Gs/&β;1/&γ;14.112018-05-1610.7554/eLife.35946
6GT3ANucleotideAdenosineA2AHomo sapiensImaradenantNa-22019-06-2610.1136/jitc-2019-000417
6JZHANucleotideAdenosineA2AHomo sapiensZM241385Na-2.252019-10-3010.1107/S1600576719012846
6LPJANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPKANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPLANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-2510.1038/s41598-020-76277-x
6MH8ANucleotideAdenosineA2AHomo sapiensZM241385--4.22019-04-2410.1107/S205225251900263X
6PS7ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.852019-11-1310.1107/S2052252519013137
6S0LANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6S0QANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6WQAANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-1810.1107/S2052252520012701
6ZDRANucleotideAdenosineA2AHomo sapiensHMS1413f12Na-1.922020-09-1610.1002/anie.202003788
6ZDVANucleotideAdenosineA2AHomo sapiensPubChem 984073Na-2.132020-09-1610.1002/anie.202003788
7AROANucleotideAdenosineA2AHomo sapiensLUF5833Na-3.122021-04-0710.1021/acs.jmedchem.0c01856
7EZCANucleotideAdenosineA2AHomo sapiensUKA--3.82022-04-1310.1107/S2052252522001907
7PX4ANucleotideAdenosineA2AHomo sapiensPSB-2113--2.252022-03-0210.1002/anie.202115545
7PYRANucleotideAdenosineA2AHomo sapiensPSB-2115--2.62022-03-0210.1002/anie.202115545
7RM5ANucleotideAdenosineA2AHomo sapiensZM241385Na-2.792021-09-0810.1073/pnas.2106041118
7T32ANucleotideAdenosineA2AHomo sapiensZM241385--3.42022-08-1010.1038/s41467-022-32125-2
8A2OANucleotideAdenosineA2AHomo sapiensTheophyllineNa-3.452023-08-3010.1107/S1600576723006428
8A2PANucleotideAdenosineA2AHomo sapiensLUAA47070Na-3.52023-08-3010.1107/S1600576723006428
8C9WANucleotideAdenosineA2AHomo sapiensEtrumadenant--2.112023-07-1210.1038/s42004-023-00894-6
8CICANucleotideAdenosineA2AHomo sapiensEtrumadenantNa-2.12023-05-3110.1038/s42004-023-00894-6
8CU6ANucleotideAdenosineA2AHomo sapiensLJ-4517--2.82022-08-3110.1021/acs.jmedchem.2c00462
8CU7ANucleotideAdenosineA2AHomo sapiensLJ-4517Na-2.052022-08-3110.1021/acs.jmedchem.2c00462
8DU3ANucleotideAdenosineA2AHomo sapiensPubChem 105526064--2.52022-08-1010.1016/j.ejmech.2022.114620
8FYNANucleotideAdenosineA2AHomo sapiensZM241385Na-22023-03-0810.1038/s41467-023-36733-4
8GNEANucleotideAdenosineA2AHomo sapiensKW-6356Na-2.32023-03-2210.1124/molpharm.122.000633
8GNGANucleotideAdenosineA2AHomo sapiensIstradefylline--3.22023-03-2210.1124/molpharm.122.000633
8JWYANucleotideAdenosineA2AHomo sapiensPubChem 168451710--2.332023-08-1610.1007/s11427-023-2459-8
8JWZANucleotideAdenosineA2AHomo sapiensAB928Na-2.372023-08-1610.1007/s11427-023-2459-8
8PWNANucleotideAdenosineA2AHomo sapiensTheophylline--2.752023-10-2510.1038/s42004-023-01014-0




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