Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y9 9.324515
2R:R:E13 8.62516
3R:R:N24 7.6875409
4R:R:N34 11.004536
5R:R:F44 4.94407
6R:R:L48 5.93429
7R:R:D52 7.905429
8R:R:I60 4.912506
9R:R:F62 8.58455
10R:R:S67 6.5725413
11R:R:F70 5.85667607
12R:R:F83 7.94455
13R:R:Q89 9.092545
14R:R:I92 5.2975407
15R:R:F93 9.83445
16R:R:R102 7.0425469
17R:R:I135 5.825444
18R:R:P173 6.9125494
19R:R:Y176 7.78506
20R:R:F182 10.4325105
21R:R:F183 5.14754104
22R:R:L194 3.3575404
23R:R:Y197 6.25609
24R:R:E228 5.112507
25R:R:F242 8.555629
26R:R:W246 11.95428
27R:R:Y271 9.025413
28R:R:H278 4.9275406
29R:R:N280 6.8075429
30R:R:V282 2.595407
31R:R:N284 6.226529
32R:R:I287 5.16754128
33R:R:Y288 5.2409
34R:R:E294 9.21536
35L:L:?3 9.523641110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E13 R:R:Y9 19.278317.96YesYes165
2R:R:E13 R:R:I60 32.37258.2YesYes066
3R:R:E13 R:R:H278 34.55678.62YesYes066
4R:R:H278 R:R:S277 78.33644.18YesNo067
5R:R:S277 R:R:W246 79.11859.88NoYes078
6R:R:N280 R:R:W246 45.33277.91YesYes298
7R:R:N280 R:R:N284 59.92964.09YesYes299
8R:R:N284 R:R:Y288 34.62385.81YesYes099
9R:R:V27 R:R:Y288 26.72485.05NoYes099
10R:R:F295 R:R:V27 25.55163.93NoNo089
11R:R:A30 R:R:F295 23.17194.16NoNo088
12R:R:A30 R:R:T298 21.96535.03NoNo087
13R:R:N34 R:R:T298 13.28428.77YesNo067
14R:R:F242 R:R:W246 35.612513.03YesYes298
15R:R:F242 R:R:L95 73.23056.09YesNo098
16R:R:L48 R:R:L95 66.44885.54YesNo098
17R:R:L48 R:R:S94 1004.5YesNo097
18R:R:S47 R:R:S94 98.62026.52NoNo097
19R:R:I125 R:R:S47 92.98924.64NoNo089
20R:R:F44 R:R:I125 91.55355.02YesNo078
21R:R:F44 R:R:I98 87.17953.77YesNo078
22R:R:I98 R:R:L235 85.69914.28NoNo088
23R:R:L235 R:R:Y197 84.185217.58NoYes089
24R:R:R102 R:R:Y197 25.26674.12YesYes099
25R:R:D101 R:R:R102 19.51857.15NoYes699
26R:R:D101 R:R:Y112 17.64715.75NoNo097
27R:R:V116 R:R:Y112 13.943410.09NoNo077
28R:R:L48 R:R:N284 39.37779.61YesYes299
29R:R:F83 R:R:L87 12.00499.74YesNo057
30R:R:F62 R:R:F83 14.30656.43YesYes555
31R:R:F62 R:R:I80 21.412215.07YesNo056
32R:R:F70 R:R:I80 23.59095.02YesNo076
33R:R:F70 R:R:I66 37.29963.77YesNo074
34L:L:?3 R:R:I66 39.38333.74YesNo004
35L:L:?3 R:R:S67 11.3966.89YesYes103
36L:L:?3 R:R:Y271 11.407212.3YesYes103
37L:L:?3 R:R:I274 50.522324.34YesNo104
38R:R:H278 R:R:I274 53.68423.98YesNo064
39R:R:L78 R:R:M140 10.30117.07NoNo065
40R:R:L137 R:R:M140 11.99935.65NoNo035
41R:R:L137 R:R:V86 13.68645.96NoNo034
42R:R:G136 R:R:V86 17.0273.68NoNo064
43R:R:G136 R:R:I135 18.68051.76NoYes064
44R:R:I135 R:R:Q89 18.334212.35YesYes445
45R:R:I92 R:R:Q89 37.24374.12YesYes075
46R:R:F242 R:R:I92 60.91847.54YesYes097
47R:R:C185 R:R:Q89 10.60839.16NoYes455
48L:L:?3 R:R:H250 40.32184.22YesNo006
49R:R:F182 R:R:H250 32.813824.89YesNo056
50R:R:F182 R:R:V186 36.02033.93YesNo057
51R:R:I92 R:R:V186 36.40586.14YesNo077
52R:R:I238 R:R:L95 20.37324.28NoNo088
53R:R:A99 R:R:Y197 17.84265.34NoYes099
54R:R:A99 R:R:M193 15.90416.44NoNo098
55R:R:A232 R:R:Y197 43.62885.34NoYes079
56R:R:A232 R:R:I200 41.84683.25NoNo079
57R:R:I200 R:R:Y103 40.0482.42NoNo098
58R:R:R107 R:R:Y103 38.42247.2NoNo068
59R:R:E228 R:R:R107 31.08763.49YesNo076
60R:R:H250 R:R:N181 11.12795.1NoNo065
61L:L:?3 R:R:M270 18.82028.34YesNo004
62R:R:F180 R:R:Y176 14.30095.16NoYes046
63R:R:M193 R:R:V239 10.02189.13NoNo088
64R:R:E228 R:R:L225 17.84263.98YesNo074
65R:R:I238 R:R:I287 18.92077.36NoYes088
66R:R:I237 R:R:I287 12.6254.42NoYes068
67R:R:I237 R:R:K233 11.09442.91NoNo067
68R:R:I252 R:R:M270 12.06082.92NoNo054
69R:R:I16 R:R:I60 18.76432.94NoYes076
70R:R:I16 R:R:V12 16.45723.07NoNo075
71R:R:V12 R:R:V8 14.13891.6NoNo055
72R:R:S7 R:R:V8 11.80941.62NoNo045
73R:R:C185 R:R:F180 14.8266.98NoNo054
74R:R:F242 R:R:N280 15.457212.08YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S67 R:R:Y9 7.63 1 Yes Yes 3 5 1 2
R:R:Y271 R:R:Y9 8.94 1 Yes Yes 3 5 1 2
R:R:F70 R:R:I66 3.77 0 Yes No 7 4 2 1
L:L:?3 R:R:I66 3.74 1 Yes No 0 4 0 1
R:R:S67 R:R:Y271 10.17 1 Yes Yes 3 3 1 1
L:L:?3 R:R:S67 6.89 1 Yes Yes 0 3 0 1
R:R:C82 R:R:L85 4.76 0 No No 5 4 2 1
R:R:L85 R:R:M177 4.24 1 No No 4 6 1 1
L:L:?3 R:R:L85 4.54 1 Yes No 0 4 0 1
R:R:F168 R:R:L167 18.27 0 No No 4 4 1 2
R:R:E169 R:R:F168 7 0 No No 3 4 2 1
L:L:?3 R:R:F168 10.38 1 Yes No 0 4 0 1
R:R:E169 R:R:M174 6.77 0 No No 3 4 2 2
R:R:E169 R:R:H264 12.31 0 No No 3 2 2 2
R:R:M174 R:R:N253 5.61 0 No No 4 5 2 1
L:L:?3 R:R:M177 5.56 1 Yes No 0 6 0 1
R:R:H250 R:R:N181 5.1 0 No No 6 5 1 2
R:R:F182 R:R:H250 24.89 10 Yes No 5 6 2 1
R:R:I274 R:R:L249 7.14 1 No No 4 5 1 1
L:L:?3 R:R:L249 17.25 1 Yes No 0 5 0 1
L:L:?3 R:R:H250 4.22 1 Yes No 0 6 0 1
L:L:?3 R:R:N253 7.2 1 Yes No 0 5 0 1
R:R:H264 R:R:M270 3.94 0 No No 2 4 2 1
R:R:L267 R:R:Y271 4.69 0 No Yes 3 3 2 1
L:L:?3 R:R:M270 8.34 1 Yes No 0 4 0 1
L:L:?3 R:R:Y271 12.3 1 Yes Yes 0 3 0 1
R:R:H278 R:R:I274 3.98 0 Yes No 6 4 2 1
L:L:?3 R:R:I274 24.34 1 Yes No 0 4 0 1
R:R:A273 R:R:L249 3.15 0 No No 6 5 2 1
R:R:I252 R:R:M270 2.92 0 No No 5 4 2 1
R:R:S67 R:R:T68 1.6 1 Yes No 3 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Single3REYPubChem 56973REY-A2A-PubChem 5697
66.67Single3PWHZM2413853PWH-A2A-ZM241385
66.67Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
66.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
66.67Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
66.67Single8JWZAB9288JWZ-A2A-AB928-Na
64.29Single5NM2ZM2413855NM2-A2A-ZM241385-Na
61.54Single5IU4ZM2413855IU4-A2A-ZM241385-Na
61.54Single5IUBQ274563445IUB-A2A-Q27456344-Na
61.54Single5K2CZM2413855K2C-A2A-ZM241385-Na
61.54Single5NM4ZM2413855NM4-A2A-ZM241385-Na
61.54Single6AQFZM2413856AQF-A2A-ZM241385
60.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
58.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
58.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
57.14Single4EIYZM2413854EIY-A2A-ZM241385-Na
57.14Single5IU8Q274563475IU8-A2A-Q27456347-Na
57.14Single5OLGZM2413855OLG-A2A-ZM241385-Na
57.14Single6LPJZM2413856LPJ-A2A-ZM241385-Na
57.14Single6LPKZM2413856LPK-A2A-ZM241385-Na
57.14Single7PYRPSB-21157PYR-A2A-PSB-2115
57.14Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
57.14Single8CU6LJ-45178CU6-A2A-LJ-4517
57.14Consensusa2_offOrthosteric Liganda2a_off
57.14Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
56.25Single8JJLOlodaterol8JJL-β2-Olodaterol
54.55Single3RFMCaffeine3RFM-A2A-Caffeine
53.85Single5K2DZM2413855K2D-A2A-ZM241385
53.85Single6JZHZM2413856JZH-A2A-ZM241385-Na
53.85Single6PS7ZM2413856PS7-A2A-ZM241385-Na
53.85Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
53.85Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
53.33Single5IUAQ274563485IUA-A2A-Q27456348-Na
53.33Single6LPLZM2413856LPL-A2A-ZM241385-Na
53.33Single6S0QZM2413856S0Q-A2A-ZM241385
53.33Single6WQAZM2413856WQA-A2A-ZM241385-Na
53.33Single7RM5ZM2413857RM5-A2A-ZM241385-Na
53.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
53.33Single8FYNZM2413858FYN-A2A-ZM241385-Na
53.33Single8GNEKW-63568GNE-A2A-KW-6356-Na
52.94Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
50.00Single3P0GBI1671073P0G-β2-BI167107
50.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
50.00Single3UZAGTPL92363UZA-A2A-GTPL9236
50.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
50.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
50.00Single5JTBZM2413855JTB-A2A-ZM241385
50.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
50.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
50.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
50.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
50.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
50.00Single7AROLUF58337ARO-A2A-LUF5833-Na
50.00Single7PX4PSB-21137PX4-A2A-PSB-2113
50.00Single7T32ZM2413857T32-A2A-ZM241385
50.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
50.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
50.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
50.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
47.37Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
47.06Single6MXTSalmeterol6MXT-β2-Salmeterol
47.06Single8JJ8Formoterol8JJ8-β2-Formoterol
46.67Single3EMLZM2413853EML-A2A-ZM241385
46.67Single5K2AZM2413855K2A-A2A-ZM241385-Na
46.67Single5UENDU1725UEN-A1-DU172
46.67Single5VRAZM2413855VRA-A2A-ZM241385-Na
46.67Single6PS1Timolol6PS1-β2-Timolol
46.67Single6S0LZM2413856S0L-A2A-ZM241385
46.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
46.67Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
46.67Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
46.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
46.15Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
45.00Single3QAKUK-4320973QAK-A2A-UK-432097
45.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
45.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
44.44Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
44.44Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
44.44Single6H7LDobutamine6H7L-β1-Dobutamine
44.44Single7EZCUKA7EZC-A2A-UKA
44.44Single7UM4AS26747237UM4-5-HT5A-AS2674723
44.44Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
43.75Single2Y00Dobutamine2Y00-β1-Dobutamine
43.75Single5N2SPSB365N2S-A1-PSB36
43.75Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
43.75Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
43.75Single6E67BI1671076E67-β2-BI167107-Gs (fused)
43.75Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
43.75Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
43.75Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
43.75Single7XKAEpinephrine7XKA-β2-Epinephrine
43.75Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
43.75Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
43.75Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
42.86Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
42.86Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
42.86Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
42.86Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
42.11Single3NY9PubChem 9131033NY9-β2-PubChem 913103
42.11Single4UG2CGS216804UG2-A2A-CGS21680
42.11Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
42.11Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
41.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
41.18Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
41.18Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
41.18Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
41.18Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
41.18Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
41.18Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
41.18Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
41.18Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
41.18Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
41.18Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
41.18Consensusa2_onOrthosteric Liganda2a_on a2b_on
41.18Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
40.91Single7C61Ergotamine7C61-5-HT1B-Ergotamine
40.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
40.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
40.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
40.00Single5UVIZM2413855UVI-A2A-ZM241385
40.00Single6MH8ZM2413856MH8-A2A-ZM241385
40.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
40.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
40.00Single7F8XNN90567F8X-CCKA-NN9056
40.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGKEpinephrine8GGK-β2-Epinephrine
40.00Single8GGMEpinephrine8GGM-β2-Epinephrine
40.00Single8GGPEpinephrine8GGP-β2-Epinephrine
40.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
40.00Single8GGTEpinephrine8GGT-β2-Epinephrine
40.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
40.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
40.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
40.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
38.89Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
38.89Single4LDEBI1671074LDE-β2-BI167107
38.89Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
38.89Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
38.89Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
38.89Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Single7YITNalfurafine7YIT-κ-Nalfurafine
38.89Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
38.89Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
38.89Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
38.89Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
38.89Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
38.89Consensusdp_offOrthosteric Liganddp2_off
38.89Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.89Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
38.46Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
38.46Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
38.46Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
38.10Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
38.10Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
38.10Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
37.50Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
37.50Single2Y01Dobutamine2Y01-β1-Dobutamine
37.50Single2Y02Carmoterol2Y02-β1-Carmoterol
37.50Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
37.50Single3NY8ICI 118-5513NY8-β2-ICI 118-551
37.50Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
37.50Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
37.50Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
37.50Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
37.50Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
37.50Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
37.50Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
37.50Single6D27CAY104716D27-DP2-CAY10471
37.50Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
37.50Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
37.50Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
37.50Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
37.50Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
37.50Single7BU7BI1671077BU7-β1-BI167107
37.50Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
37.50Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
37.50Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
37.50Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
37.50Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
37.50Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGJEpinephrine8GGJ-β2-Epinephrine
37.50Single8GGNEpinephrine8GGN-β2-Epinephrine
37.50Single8GGOEpinephrine8GGO-β2-Epinephrine
37.50Single8GGUEpinephrine8GGU-β2-Epinephrine
37.50Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
37.50Single8JJOAlprenolol8JJO-β2-Alprenolol
37.50Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
37.50Consensusadenosine_onOrthosteric Liganda1_on a2_on
37.50Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
37.50Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
37.50Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
37.50Consensusnucleotide_onOrthosteric Ligandadenosine_on
36.84Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
36.84Single6IBLArformoterol6IBL-β1-Arformoterol
36.84Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
36.84Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
36.84Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
36.84Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
36.84Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
36.36Single5MZPCaffeine5MZP-A2A-Caffeine-Na
36.36Single5WF5UK-4320975WF5-A2A-UK-432097
36.36Single6PT2KGCHM076PT2-δ-KGCHM07
36.36Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
35.71Single3PBLEticlopride3PBL-D3-Eticlopride
35.71Single6HLLCP999946HLL-NK1-CP99994
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.71Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
35.71Single8GGSEpinephrine8GGS-β2-Epinephrine
35.71Single8GGYEpinephrine8GGY-β2-Epinephrine
35.71Single8GH1Epinephrine8GH1-β2-Epinephrine
35.71Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.71Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
35.29Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
35.29Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
35.29Single5C1MBU725C1M-μ-BU72
35.29Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
35.29Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
35.29Single5TVNLSD5TVN-5-HT2B-LSD
35.29Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.29Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
35.29Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
35.29Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
35.29Single6PS6Timolol6PS6-β2-Timolol
35.29Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
35.29Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
35.29Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
35.29Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
35.29Single7WC6LSD7WC6-5-HT2A-LSD
35.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
35.29Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
35.29Single8QOTNanobody E8QOT-μ-Nanobody E
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
35.29Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
35.29Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
35.29Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
35.29Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
35.29Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
35.29Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
35.29Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
35.29Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
35.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
35.29Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
35.29Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single5WF6UK-4320975WF6-A2A-UK-432097
35.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
35.00Single6PT3DPI-2876PT3-δ-DPI-287
35.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
35.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single8X5YAstemizole8X5Y-H1-Astemizole
35.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
35.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
35.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
35.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
35.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
35.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
35.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
34.78Single6JODAngiotensin II6JOD-AT2-Angiotensin II
34.78Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
34.78Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
33.33Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
33.33Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6J20Aprepitant6J20-NK1-Aprepitant
33.33Single6J21Aprepitant6J21-NK1-Aprepitant
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6KUXRS-799486KUX-α2a-RS-79948
33.33Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
33.33Single6WGTLSD6WGT-5-HT2A-LSD
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
33.33Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
33.33Single7F8ULintitript7F8U-CCKA-Lintitript
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
33.33Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
33.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
33.33Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
33.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
33.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
33.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGVEpinephrine8GGV-β2-Epinephrine
33.33Single8GGXEpinephrine8GGX-β2-Epinephrine
33.33Single8GH0Epinephrine8GH0-β2-Epinephrine
33.33Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
33.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
33.33Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
33.33Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
33.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
33.33Single8PWNTheophylline8PWN-A2A-Theophylline
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
33.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
33.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
33.33Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
33.33Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
33.33Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
33.33Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
33.33Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
33.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
33.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
33.33Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
33.33Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
33.33Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
33.33Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
32.14Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
32.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
32.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
31.82Single6HLOAprepitant6HLO-NK1-Aprepitant
31.82Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
31.82Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
31.82Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
31.58Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
31.58Single4AMIBucindolol4AMI-β1-Bucindolol
31.58Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
31.58Single6A93Risperidone6A93-5-HT2A-Risperidone
31.58Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
31.58Single6CM4Risperidone6CM4-D2-Risperidone
31.58Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
31.58Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
31.58Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
31.58Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
31.58Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
31.58Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
31.58Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
31.58Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
31.58Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
31.58Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
31.58Single8WU1KCA8WU1-CB1-KCA-Arrestin1
31.58Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
31.58Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
31.58Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
31.58Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.58Consensusgs_steroidOrthosteric Ligandgs_bileacid
31.58Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
31.58Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
31.58Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
31.25Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
31.25Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
31.25Single6DS0Ly2660976DS0-5-HT2B-Ly266097
31.25Single6IQLL7458706IQL-D4-L745870
31.25Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
31.25Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
31.25Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
31.25Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
31.25Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.25Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
31.25Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
31.25Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
31.25Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8GGIEpinephrine8GGI-β2-Epinephrine
31.25Single8GGLEpinephrine8GGL-β2-Epinephrine
31.25Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
31.25Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
31.25Consensus5ht5_onOrthosteric Ligand5ht5a_on
31.25Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
31.25Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
31.25Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
31.25Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
31.25Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
30.77Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
30.77Consensusendothelin_onOrthosteric Ligandetb_on eta_on
30.43Single6W25SHU91196W25-MC4-SHU9119-Ca
30.43Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
30.43Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
30.43Consensusangiotensin_onOrthosteric Ligandat1_on
30.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
30.43Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
30.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
30.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
30.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
30.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
30.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
30.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
30.00Consensusendothelin_offOrthosteric Ligandetb_off
30.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
30.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
30.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusorexin_onOrthosteric Ligandox2_on
30.00Consensussteroid_onOrthosteric Ligandbileacid_on
29.63Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
29.63Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
29.41Single2Y04Salbutamol2Y04-β1-Salbutamol
29.41Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
29.41Single4EJ4Naltrindole4EJ4-δ-Naltrindole
29.41Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
29.41Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
29.41Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
29.41Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
29.41Single6H7MSalbutamol6H7M-β1-Salbutamol
29.41Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
29.41Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
29.41Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
29.41Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
29.41Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
29.41Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.41Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
29.41Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
29.41Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
29.41Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
29.41Single7WC7Lisuride7WC7-5-HT2A-Lisuride
29.41Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
29.41Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
29.41Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
29.41Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Single8X63Mepyramine8X63-H1-Mepyramine
29.41Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
29.41Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
29.41Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
29.41Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
29.41Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
29.41Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
29.41Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
29.41Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
29.41Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
29.41Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
29.41Consensustachykinin_offOrthosteric Ligandnk1_off
29.17Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.17Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
29.17Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
29.17Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.17Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.17Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
29.17Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
28.57Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
28.57Single7SK9CCX6627SK9-ACKR3-CCX662
28.57Single7WC5Psilocin7WC5-5-HT2A-Psilocin
28.57Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7XN9L-054,5227XN9-SST2-L-054,522
28.57Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Single8GGREpinephrine8GGR-β2-Epinephrine
28.57Single8GGZEpinephrine8GGZ-β2-Epinephrine
28.57Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
28.57Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
28.57Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
28.57Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
28.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
28.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
28.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
28.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
28.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single2Y03Isoprenaline2Y03-β1-Isoprenaline
27.78Single4NTJAZD12834NTJ-P2Y12-AZD1283
27.78Single5WIUNemonapride5WIU-D4-Nemonapride
27.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
27.78Single5XPRBosentan5XPR-ETB-Bosentan
27.78Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
27.78Single6LUQHaloperidol6LUQ-D2-Haloperidol
27.78Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
27.78Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
27.78Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
27.78Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.78Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
27.78Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
27.78Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
27.78Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
27.78Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
27.78Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
27.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
27.78Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
27.78Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
27.78Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
27.78Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
27.78Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
27.78Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
27.78Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
27.78Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Single4XT1Fractalkine4XT1-US28-Fractalkine
27.27Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
27.27Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
27.27Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
27.27Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
27.27Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single4XT3Fractalkine4XT3-US28-Fractalkine
26.92Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
26.92Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
26.92Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
26.92Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
26.92Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
26.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
26.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single7SRQLSD7SRQ-5-HT2B-LSD
26.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
26.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
26.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
26.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.32Single5V54Methiothepin5V54-5-HT1B-Methiothepin
26.32Single5X93K-87945X93-ETB-K-8794
26.32Single5XRAAM115425XRA-CB1-AM11542
26.32Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
26.32Single6E59L-7607356E59-NK1-L-760735
26.32Single6TQ7SB-3348676TQ7-OX1-SB-334867
26.32Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.32Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
26.32Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
26.32Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
26.32Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
26.32Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
26.32Single7W41PD1762527W41-BB2-PD176252
26.32Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
26.32Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
26.32Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.32Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
26.32Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
26.32Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
26.32Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.32Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
26.32Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
26.32Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
26.32Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
26.32Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
26.32Consensus5ht1_offOrthosteric Ligand5ht1b_off
26.32Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
26.32Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
26.32Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
26.32Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.32Consensusbombesin_offOrthosteric Ligandbb2_off
26.32Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.32Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
26.32Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.32Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.32Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.32Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
26.32Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
26.32Consensushistamine_offOrthosteric Ligandh1_off
26.32Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
26.32Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
26.32Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.32Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.09Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
26.09Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
26.09Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
26.09Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
26.09Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
26.09Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.93Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
25.93Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.93Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
25.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single5DHHSB-6121115DHH-NOP-SB-612111
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.00Single6HLPNetupitant6HLP-NK1-Netupitant
25.00Single6IGLIRL16206IGL-ETB-IRL1620
25.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
25.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6OS2TRV0266OS2-AT1-TRV026
25.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
25.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
25.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
25.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7K15MKD0467K15-BLT1-MKD046-Na
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
25.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
25.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
25.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
25.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
25.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
25.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GGWEpinephrine8GGW-β2-Epinephrine
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
25.00Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IWESpermidine8IWE-TAAR9-Spermidine
25.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
25.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
25.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
25.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
25.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
25.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
25.00Consensusblt_offOrthosteric Ligandblt1_off
25.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
25.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
25.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
24.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
24.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
24.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
24.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.81Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.81Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
23.81Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
23.81Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
23.81Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
23.81Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
23.81Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
23.81Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
23.81Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
23.81Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
23.81Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
23.81Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
23.81Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
23.81Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
23.81Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
23.81Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
23.81Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
23.81Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
23.81Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.81Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.53Single2YDOAdenosine2YDO-A2A-Adenosine
23.53Single3RZECidoxepin3RZE-H1-Cidoxepin
23.53Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
23.53Single4MBSMaraviroc4MBS-CCR5-Maraviroc
23.53Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
23.53Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
23.53Single6A94Zotepine6A94-5-HT2A-Zotepine
23.53Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
23.53Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
23.53Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.53Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
23.53Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.53Single6TPGEMPA6TPG-OX2-EMPA
23.53Single6TPNHTL66416TPN-OX2-HTL6641
23.53Single6V9SGTPL114036V9S-OX1-GTPL11403
23.53Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
23.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.53Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.53Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
23.53Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
23.53Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.53Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
23.53Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
23.53Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
23.53Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
23.53Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.53Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
23.53Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
23.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
23.53Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
23.53Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
23.53Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
23.53Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
23.53Single8K5CAcipimox8K5C-HCA2-Acipimox
23.53Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
23.53Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
23.53Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
23.53Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
23.53Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.53Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
23.53Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
23.53Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
23.53Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
23.53Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
23.53Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
23.53Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
23.53Consensuss1p_offOrthosteric Ligands1p1_off
23.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
23.08Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
23.08Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
23.08Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single5ZTYAM102575ZTY-CB2-AM10257
22.73Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
22.73Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
22.73Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
22.73Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
22.73Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
22.73Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
22.73Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
22.73Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.73Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.22Single4DAJTiotropium4DAJ-M3-Tiotropium
22.22Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single4MQSIperoxo4MQS-M2-Iperoxo
22.22Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
22.22Single4U14Tiotropium4U14-M3-Tiotropium
22.22Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
22.22Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single4YAYZD-71554YAY-AT1-ZD-7155
22.22Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
22.22Single5DSGTiotropium5DSG-M4-Tiotropium
22.22Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
22.22Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
22.22Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
22.22Single6DRXLisuride6DRX-5-HT2B-Lisuride
22.22Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
22.22Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
22.22Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
22.22Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
22.22Single6TOTLemborexant6TOT-OX1-Lemborexant
22.22Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
22.22Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
22.22Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
22.22Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
22.22Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
22.22Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
22.22Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
22.22Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
22.22Single7UL4Alvimopan7UL4-μ-Alvimopan
22.22Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
22.22Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
22.22Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
22.22Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
22.22Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.22Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.22Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
22.22Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
22.22Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
22.22Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.22Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.22Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
22.22Single8K5DGSK2560738K5D-HCA2-GSK256073
22.22Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
22.22Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
22.22Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8X64Desloratadine8X64-H1-Desloratadine
22.22Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
22.22Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
22.22Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
22.22Consensusblt_onOrthosteric Ligandblt1_on
22.22Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
22.22Consensuscck_offOrthosteric Ligandccka_off
22.22Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
22.22Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
22.22Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Consensusgi_hcarOrthosteric Ligandgi_hca
22.22Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
22.22Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
22.22Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Consensushistamine_onOrthosteric Ligandh1_on h4_on
22.22Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.22Consensusleuko_onOrthosteric Ligandblt_on
22.22Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
22.22Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.22Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
22.22Consensustar_onOrthosteric Ligandta1_on
21.88Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.88Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
21.74Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
21.74Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
21.74Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
21.74Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.74Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
21.74Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
21.74Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
21.74Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
21.74Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
21.74Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
21.74Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
21.74Consensussst_onOrthosteric Ligandsst2_on sst4_on
21.62Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
21.43Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.43Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.43Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
21.43Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
21.43Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.43Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
21.05Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
21.05Single5WQCEMPA5WQC-OX2-EMPA
21.05Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
21.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.05Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.05Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
21.05Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
21.05Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
21.05Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
21.05Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
21.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
21.05Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
21.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
21.05Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8EA0Iperoxo8EA0-M3-Iperoxo
21.05Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
21.05Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
21.05Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
21.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
21.05Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
21.05Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
21.05Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.83Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.83Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
20.83Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.83Single7SK5CXCL127SK5-ACKR3-CXCL12
20.83Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
20.83Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
20.83Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
20.69Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
20.69Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
20.69Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.69Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
20.00Single4U15Tiotropium4U15-M3-Tiotropium
20.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
20.00Single5V56TC1145V56-SMO-TC114
20.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single5XR8AM8415XR8-CB1-AM841
20.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
20.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
20.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
20.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single6OL9Tiotropium6OL9-M5-Tiotropium
20.00Single6OS1TRV0266OS1-AT1-TRV026
20.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
20.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
20.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
20.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
20.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
20.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
20.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
20.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
20.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
20.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
20.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
20.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
20.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
20.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
20.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
20.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
20.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
20.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
20.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
20.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
20.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
20.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
20.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
19.35Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
19.23Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
19.23Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
19.23Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
19.23Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single4N4WSANT-14N4W-SMO-SANT-1
19.05Single4XEENeurotensin4XEE-NTS1-Neurotensin
19.05Single4XESNeurotensin4XES-NTS1-Neurotensin
19.05Single5CXVTiotropium5CXV-M1-Tiotropium
19.05Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
19.05Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
19.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
19.05Single6ZG4HTL00099366ZG4-M1-HTL0009936
19.05Single7DFPSpiperone7DFP-D2-Spiperone
19.05Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
19.05Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
19.05Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
19.05Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
19.05Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
19.05Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
19.05Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
19.05Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
19.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
19.05Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
19.05Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
19.05Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
19.05Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
19.05Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
19.05Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
19.05Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
19.05Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
19.05Consensusclass-b2_onOrthosteric Ligandadgrg_on
19.05Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
19.05Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
19.05Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
19.05Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
19.05Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
19.05Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
19.05Consensusnts_offOrthosteric Ligandnts1_off
19.05Consensusnts_onOrthosteric Ligandnts1_on
19.05Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
19.05Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.75Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
18.75Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
18.75Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
18.75Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
18.75Single3OE9IT1t3OE9-CXCR4-IT1t
18.75Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
18.75Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
18.75Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
18.75Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.75Single6TP4ACT-4622066TP4-OX1-ACT-462206
18.75Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
18.75Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
18.75Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
18.75Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
18.75Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
18.75Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
18.75Single8K5BNiacin8K5B-HCA2-Niacin
18.75Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.75Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.75Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
18.75Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
18.75Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.75Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
18.75Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
18.75Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
18.52Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.52Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
18.52Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
18.52Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
18.52Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.52Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single4BUONeurotensin4BUO-NTS1-Neurotensin
18.18Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.18Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
18.18Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
18.18Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
18.18Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.18Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
18.18Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
18.18Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.18Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
18.18Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
18.18Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
18.18Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
18.18Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
18.18Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
18.18Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
17.65Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
17.65Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
17.65Single4S0VSuvorexant4S0V-OX2-Suvorexant
17.65Single5WS3EMPA5WS3-OX2-EMPA
17.65Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.65Single6AKYMaraviroc6AKY-CCR5-Maraviroc
17.65Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.65Single6TODEMPA6TOD-OX1-EMPA-Na
17.65Single6TPJSuvorexant6TPJ-OX2-Suvorexant
17.65Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
17.65Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
17.65Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
17.65Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.65Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
17.65Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.65Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
17.65Consensusmglu_onOther Ligandmglu2_on mglu4_on
17.65Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
17.65Consensusorexin_offOrthosteric Ligandox2_off ox1_off
17.39Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.39Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
17.39Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
17.39Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
17.39Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
17.39Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
17.39Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
17.39Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
17.39Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
17.39Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.24Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
17.24Consensusgo_class-b1Orthosteric Ligandgo_crf
17.24Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
16.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
16.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.67Single6TPKRetosiban6TPK-OT-Retosiban
16.67Single6VI4JDTic6VI4-κ-JDTic
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
16.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
16.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
16.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
16.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
16.67Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
16.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
16.67Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
16.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
16.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
16.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
16.67Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
16.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
16.67Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
16.67Single8K2WAMG4878K2W-CXCR3-AMG487
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
16.67Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
16.67Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.67Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
16.67Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.67Consensusgnrh_offOrthosteric Ligandgnrh1_off
16.67Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
16.67Consensushca_onOrthosteric Ligandhca2_on hca3_on
16.67Consensushcar_onOrthosteric Ligandhca_on
16.67Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
16.67Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
16.67Consensussensory_offOrthosteric Ligandopsin_off
16.67Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
16.67Consensusvasopressin-ot_offOrthosteric Ligandot_off
16.13Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.13Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.13Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.13Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
16.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
16.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.00Consensussst_offOrthosteric Ligandsst2_off
15.79Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
15.79Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
15.79Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.79Single6GPSMK08126GPS-CCR2-MK0812
15.79Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
15.79Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
15.79Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
15.79Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
15.79Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
15.79Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.79Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
15.79Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.79Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
15.79Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.79Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.79Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.79Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
15.79Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.79Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.79Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
15.62Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.62Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
15.62Consensusglp_onOrthosteric Ligandglp1_on glp2_on
15.38Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
15.38Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
15.38Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
15.38Single7XNACYN1548067XNA-SST2-CYN154806
15.38Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
15.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
15.38Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
15.38Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
15.38Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
15.38Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.38Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.15Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
15.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
15.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
15.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
15.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.00Single6GPXMK08126GPX-CCR2-MK0812
15.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.00Single6TP6Filorexant6TP6-OX1-Filorexant
15.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.00Single6Z4SSR486926Z4S-NTS1-SR48692
15.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
15.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00Single7C4SS1P7C4S-S1P3-S1P
15.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
15.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
15.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
15.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
15.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.00Consensusep_offOrthosteric Ligandep4_off
15.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
15.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
14.81Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.81Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
14.81Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
14.81Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
14.81Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.71Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
14.71Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
14.29Single4BV0Neurotensin4BV0-NTS1-Neurotensin
14.29Single4DJHJDTic4DJH-κ-JDTic
14.29Single5V57TC1145V57-SMO-TC114
14.29Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.29Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
14.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
14.29Single7EPENAM5637EPE-mGlu-NAM563
14.29Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
14.29Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.29Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.29Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
14.29Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
14.29Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
14.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
14.29Consensusclass-c_onOther Ligandgabab_on mglu_on
14.29Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
14.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
14.29Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.79Single6FJ3PTH6FJ3-PTH1-PTH
13.79Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.79Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.79Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7SK3CXCL127SK3-ACKR3-CXCL12
13.79Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
13.79Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
13.79Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.79Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.64Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
13.64Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.64Single5X33BIIL2605X33-BLT1-BIIL260
13.64Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.64Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
13.64Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.64Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single6YVRNTS8-136YVR-NTS1-NTS8-13
13.64Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.64Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
13.64Consensusgi_class-fOther Ligandgi_frizzled
13.64Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.64Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
13.51Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.51Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
13.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.33Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
13.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.33Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.33Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
13.33Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
13.33Consensussensory_onOrthosteric Ligandopsin_on
13.16Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.16Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.04Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
13.04Single6K1QIRL25006K1Q-ETB-IRL2500
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
13.04Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.04Consensuscyslt_offOrthosteric Ligandcyslt2_off
13.04Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.04Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
12.90Single6LMLGlucagon6LML-Glucagon-Glucagon
12.90Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.90Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.50Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single3OE8IT1t3OE8-CXCR4-IT1t
12.50Single5EE7MK08935EE7-Glucagon-MK0893
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.50Single6LI0GTPL98046LI0-GPR52-GTPL9804
12.50Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
12.50Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
12.50Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
12.50Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
12.50Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
12.50Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
12.50Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.50Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
12.50Consensusgs_class-b2Orthosteric Ligandgs_adgr
12.50Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
12.50Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
12.50Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.12Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
12.12Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.12Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
12.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
12.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
12.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
11.76Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.76Single5L7IVismodegib5L7I-SMO-Vismodegib
11.76Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
11.76Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.76Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
11.76Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single7UL2SR486927UL2-NTS1-SR48692-Na
11.76Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.76Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.76Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
11.76Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
11.76Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
11.76Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
11.76Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.76Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.76Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.76Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
11.54Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.54Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
11.54Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
11.54Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
11.54Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
11.43Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
11.43Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single6B73PubChem 1319551386B73-κ-PubChem 131955138
11.11Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.11Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
11.11Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
11.11Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Single8IHKAcifran8IHK-HCA3-Acifran
11.11Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
11.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensusgt_class-aOrthosteric Ligandgt_opsin
11.11Consensusgt_opsinOrthosteric Ligandgt_sensory
11.11Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.11Consensuspth_onOrthosteric Ligandpth1_on pth2_on
10.71Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.71Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
10.71Consensusclass-d_onOrthosteric Ligandste2_on
10.71Consensusgi_class-dOrthosteric Ligandgi_ste
10.71Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.53Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.53Single6ZG9GSK10347026ZG9-M1-GSK1034702
10.53Single6ZINSR486926ZIN-NTS1-SR48692
10.53Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.53Single7VODCariprazine7VOD-5-HT2A-Cariprazine
10.53Single7VV6C48/807VV6-MRGPRX2-C48/80
10.53Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.53Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.53Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.53Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.53Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.53Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.34Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
10.34Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.34Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.34Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.00Single5TGZAM65385TGZ-CB1-AM6538
10.00Single6IIVDaltroban6IIV-TP-Daltroban
10.00Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
10.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
10.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
10.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
10.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.00Consensusclass-d_onOrthosteric Ligandste2_on
10.00Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.00Consensushcar_offOrthosteric Ligandsuccinate_off
10.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
9.68Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
9.68Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.68Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
9.68Consensusgi_class-dOrthosteric Ligandgi_ste
9.68Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.68Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.68Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.68Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.52Single5CGCHTL142425CGC-mGlu5-HTL14242
9.52Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
9.52Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.52Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.52Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.52Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
9.52Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
9.52Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
9.38Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
9.38Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
9.38Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.38Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
9.38Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.09Single7P2L4YI7P2L-mGlu5-4YI
9.09Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
8.70Single6IIURamatroban6IIU-TP-Ramatroban
8.70Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensuschemokine_offOrthosteric Ligandcxcr_off
8.70Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
8.70Consensuscxcr_offOrthosteric Ligandcxcr4_off
8.70Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.70Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
8.33Single5CGDHTL142425CGD-mGlu5-HTL14242
8.33Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
8.33Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.33Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.33Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.33Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single6KNMJN241-96KNM-Apelin-JN241-9
8.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusclass-d_offOrthosteric Ligandste2_off
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.69Single7QA8Peptide7QA8-STE2-Peptide
7.69Single7QA8Peptide7QA8-STE2-Peptide
7.69Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
7.69Consensusclass-d_offOrthosteric Ligandste2_off
7.41Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
7.14Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
7.14Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
6.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.90Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
6.90Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
6.90Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
6.67Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
6.67Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
6.67Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
6.67Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
6.67Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
6.45Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.25Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
6.25Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.25Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.25Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
6.25Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.25Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.06Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.06Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.88Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.88Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
5.88Single4XNWMRS25004XNW-P2Y1-MRS2500
5.88Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.88Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
5.88Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.88Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.88Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
5.88Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.88Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.56Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.56Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.56Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.56Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.56Consensusgo_class-b2Orthosteric Ligandgo_adhesion
5.56Consensusgo_proteinOrthosteric Ligandgo_chemokine
5.56Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26Single4QINSAG1.54QIN-SMO-SAG1.5
5.26Single5U09Taranabant5U09-CB1-Taranabant
5.26Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.26Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.26Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.26Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.26Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.13Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
5.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8IYXYL-3658IYX-GPR34-YL-365
5.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
5.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single5T04Neurotensin5T04-NTS1-Neurotensin
4.76Single6FFHFenobam6FFH-mGlu5-Fenobam
4.76Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.76Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
4.76Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.35Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.35Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.35Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.35Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
4.35Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.70Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
2.94Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.86Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.78Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.33Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 5UIG
Class A
SubFamily Nucleotide
Type Adenosine
SubType A2A
Species Homo sapiens
Ligand J3.651.884G
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.5
Date 2017-02-08
D.O.I. 10.1073/pnas.1621423114
Net Summary
Imin 3.74
Number of Linked Nodes 262
Number of Links 289
Number of Hubs 35
Number of Links mediated by Hubs 138
Number of Communities 13
Number of Nodes involved in Communities 54
Number of Links involved in Communities 64
Path Summary
Number Of Nodes in MetaPath 75
Number Of Links MetaPath 74
Number of Shortest Paths 41626
Length Of Smallest Path 3
Average Path Length 14.5645
Length of Longest Path 34
Minimum Path Strength 1.25
Average Path Strength 6.72327
Maximum Path Strength 19.145
Minimum Path Correlation 0.7
Average Path Correlation 0.929659
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 51.8457
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.2976
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code8D1
PDB ResiduesL:L:?3
Environment DetailsOpen EMBL-EBI Page
Code8D1
Name5-amino-N-[(2-methoxyphenyl)methyl]-2-(3-methylphenyl)-2H-1,2,3-triazole-4-carboximidamide
Synonyms
Identifier5-azanyl-~{N}-[(2-methoxyphenyl)methyl]-2-(3-methylphenyl)-1,2,3-triazole-4-carboximidamide
FormulaC18 H20 N6 O
Molecular Weight336.391
SMILES[H]/N=C(/c1c(nn(n1)c2cccc(c2)C)N)\NCc3ccccc3OC
PubChem124081196
Formal Charge0
Total Atoms45
Total Chiral Atoms0
Total Bonds47
Total Aromatic Bonds17

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP29274
Sequence
>5UIG_Chain_R
MGSSVYITV ELAIAVLAI LGNVLVCWA VWLNSNLQN VTNYFVVSL 
AAADIAVGV LAIPFAITI STGFCAACH GCLFIACFV LVLTQSSIF 
SLLAIAIDR YIAIRIPLR YNGLVTGTR AKGIIAICW VLSFAIGLT 
PMLGWNNCG QCGEGQVAC LFEDVVPMN YMVYFNFFA CVLVPLLLM 
LGVYLRIFL AARRQLERA RSTLQKEVH AAKSLAIIV GLFALCWLP 
LHIINCFTF FCPDCSHAP LWLMYLAIV LSHTNSVVN PFIYAYRIR 
EFRQTFRKI IRSHVLRQQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
a2a_off8C9W-A2A-Etrumadenant
3UZA-A2A-GTPL9236
8GNG-A2A-Istradefylline
5UIG-A2A-J3.651.884G
8CU6-A2A-LJ-4517
7PX4-A2A-PSB-2113
7PYR-A2A-PSB-2115
8DU3-A2A-PubChem 105526064
8JWY-A2A-PubChem 168451710
5K2D-A2A-ZM241385

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2YDOANucleotideAdenosineA2AHomo sapiensAdenosine--32011-05-1810.1038/nature10136
2YDVANucleotideAdenosineA2AHomo sapiensNECA--2.62011-05-1810.1038/nature10136
3EMLANucleotideAdenosineA2AHomo sapiensZM241385--2.62008-10-1410.1126/science.1164772
3PWHANucleotideAdenosineA2AHomo sapiensZM241385--3.32011-09-0710.1016/j.str.2011.06.014
3QAKANucleotideAdenosineA2AHomo sapiensUK-432097--2.712011-03-0910.1126/science.1202793
3REYANucleotideAdenosineA2AHomo sapiensPubChem 5697--3.312011-09-0710.1016/j.str.2011.06.014
3RFMANucleotideAdenosineA2AHomo sapiensCaffeine--3.62011-09-0710.1016/j.str.2011.06.014
3UZAANucleotideAdenosineA2AHomo sapiensGTPL9236--3.272012-03-2110.1021/jm201376w
3UZCANucleotideAdenosineA2AHomo sapiensPubChem 135566609--3.342012-03-2110.1021/jm201376w
3VG9ANucleotideAdenosineA2AHomo sapiensZM241385Antibody-2.72012-02-0110.1038/nature10750
3VGAANucleotideAdenosineA2AHomo sapiensZM241385Antibody-3.12012-02-0110.1038/nature10750
4EIYANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82012-07-2510.1126/science.1219218
4UG2ANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
4UHRANucleotideAdenosineA2AHomo sapiensCGS21680--2.62015-04-0810.1124/mol.114.097360
5G53ANucleotideAdenosineA2AHomo sapiensNECA-Gs3.42016-08-0310.1038/nature18966
5IU4ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.722016-06-2910.1021/acs.jmedchem.6b00653
5IU7ANucleotideAdenosineA2AHomo sapiensQ27456346Na-1.92016-06-2910.1021/acs.jmedchem.6b00653
5IU8ANucleotideAdenosineA2AHomo sapiensQ27456347Na-22016-06-2910.1021/acs.jmedchem.6b00653
5IUAANucleotideAdenosineA2AHomo sapiensQ27456348Na-2.22016-06-2910.1021/acs.jmedchem.6b00653
5IUBANucleotideAdenosineA2AHomo sapiensQ27456344Na-2.12016-06-2910.1021/acs.jmedchem.6b00653
5JTBANucleotideAdenosineA2AHomo sapiensZM241385--2.82017-05-3110.1126/sciadv.1602952
5K2AANucleotideAdenosineA2AHomo sapiensZM241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2BANucleotideAdenosineA2AHomo sapiensZM241385Na-2.52016-09-2110.1126/sciadv.1600292
5K2CANucleotideAdenosineA2AHomo sapiensZM241385Na-1.92016-09-2110.1126/sciadv.1600292
5K2DANucleotideAdenosineA2AHomo sapiensZM241385--1.92016-09-2110.1126/sciadv.1600292
5MZJANucleotideAdenosineA2AHomo sapiensTheophyllineNa-22017-07-2610.1016/j.str.2017.06.012
5MZPANucleotideAdenosineA2AHomo sapiensCaffeineNa-2.12017-07-2610.1016/j.str.2017.06.012
5N2RANucleotideAdenosineA2AHomo sapiensPubChem 92460631; psb36Na-2.82017-07-2610.1016/j.str.2017.06.012
5NLXANucleotideAdenosineA2AHomo sapiensZM241385Na-2.142017-09-2710.1038/s41467-017-00630-4
5NM2ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.952017-09-2710.1038/s41467-017-00630-4
5NM4ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.72017-09-2710.1038/s41467-017-00630-4
5OLGANucleotideAdenosineA2AHomo sapiensZM241385Na-1.872018-01-1710.1038/s41598-017-18570-w
5OLHANucleotideAdenosineA2AHomo sapiensVipadenantNa-2.62018-01-1710.1038/s41598-017-18570-w
5OLOANucleotideAdenosineA2AHomo sapiensTozadenantNa-3.12018-01-1710.1038/s41598-017-18570-w
5OLVANucleotideAdenosineA2AHomo sapiensLUAA41063Na-22018-01-1710.1038/s41598-017-18570-w
5OLZANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-1.92018-01-1710.1038/s41598-017-18570-w
5OM1ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-2.12018-01-1710.1038/s41598-017-18570-w
5OM4ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-22018-01-1710.1038/s41598-017-18570-w
5UVIANucleotideAdenosineA2AHomo sapiensZM241385--3.22017-05-2410.1107/S205225251700570X
5VRAANucleotideAdenosineA2AHomo sapiensZM241385Na-2.352017-12-1310.1038/nprot.2017.135
5WF5ANucleotideAdenosineA2AHomo sapiensUK-432097--2.62018-02-2110.1016/j.str.2017.12.013
5WF6ANucleotideAdenosineA2AHomo sapiensUK-432097--2.92018-02-2110.1016/j.str.2017.12.013
6AQFANucleotideAdenosineA2AHomo sapiensZM241385--2.512018-01-1010.1016/j.cell.2017.12.004
6GDGANucleotideAdenosineA2AHomo sapiensNECA-Gs/&β;1/&γ;14.112018-05-1610.7554/eLife.35946
6GT3ANucleotideAdenosineA2AHomo sapiensImaradenantNa-22019-06-2610.1136/jitc-2019-000417
6JZHANucleotideAdenosineA2AHomo sapiensZM241385Na-2.252019-10-3010.1107/S1600576719012846
6LPJANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPKANucleotideAdenosineA2AHomo sapiensZM241385Na-1.82020-11-2510.1038/s41598-020-76277-x
6LPLANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-2510.1038/s41598-020-76277-x
6MH8ANucleotideAdenosineA2AHomo sapiensZM241385--4.22019-04-2410.1107/S205225251900263X
6PS7ANucleotideAdenosineA2AHomo sapiensZM241385Na-1.852019-11-1310.1107/S2052252519013137
6S0LANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6S0QANucleotideAdenosineA2AHomo sapiensZM241385--2.652020-07-1510.1107/S2052252520011379
6WQAANucleotideAdenosineA2AHomo sapiensZM241385Na-22020-11-1810.1107/S2052252520012701
6ZDRANucleotideAdenosineA2AHomo sapiensHMS1413f12Na-1.922020-09-1610.1002/anie.202003788
6ZDVANucleotideAdenosineA2AHomo sapiensPubChem 984073Na-2.132020-09-1610.1002/anie.202003788
7AROANucleotideAdenosineA2AHomo sapiensLUF5833Na-3.122021-04-0710.1021/acs.jmedchem.0c01856
7EZCANucleotideAdenosineA2AHomo sapiensUKA--3.82022-04-1310.1107/S2052252522001907
7PX4ANucleotideAdenosineA2AHomo sapiensPSB-2113--2.252022-03-0210.1002/anie.202115545
7PYRANucleotideAdenosineA2AHomo sapiensPSB-2115--2.62022-03-0210.1002/anie.202115545
7RM5ANucleotideAdenosineA2AHomo sapiensZM241385Na-2.792021-09-0810.1073/pnas.2106041118
7T32ANucleotideAdenosineA2AHomo sapiensZM241385--3.42022-08-1010.1038/s41467-022-32125-2
8A2OANucleotideAdenosineA2AHomo sapiensTheophyllineNa-3.452023-08-3010.1107/S1600576723006428
8A2PANucleotideAdenosineA2AHomo sapiensLUAA47070Na-3.52023-08-3010.1107/S1600576723006428
8C9WANucleotideAdenosineA2AHomo sapiensEtrumadenant--2.112023-07-1210.1038/s42004-023-00894-6
8CICANucleotideAdenosineA2AHomo sapiensEtrumadenantNa-2.12023-05-3110.1038/s42004-023-00894-6
8CU6ANucleotideAdenosineA2AHomo sapiensLJ-4517--2.82022-08-3110.1021/acs.jmedchem.2c00462
8CU7ANucleotideAdenosineA2AHomo sapiensLJ-4517Na-2.052022-08-3110.1021/acs.jmedchem.2c00462
8DU3ANucleotideAdenosineA2AHomo sapiensPubChem 105526064--2.52022-08-1010.1016/j.ejmech.2022.114620
8FYNANucleotideAdenosineA2AHomo sapiensZM241385Na-22023-03-0810.1038/s41467-023-36733-4
8GNEANucleotideAdenosineA2AHomo sapiensKW-6356Na-2.32023-03-2210.1124/molpharm.122.000633
8GNGANucleotideAdenosineA2AHomo sapiensIstradefylline--3.22023-03-2210.1124/molpharm.122.000633
8JWYANucleotideAdenosineA2AHomo sapiensPubChem 168451710--2.332023-08-1610.1007/s11427-023-2459-8
8JWZANucleotideAdenosineA2AHomo sapiensAB928Na-2.372023-08-1610.1007/s11427-023-2459-8
8PWNANucleotideAdenosineA2AHomo sapiensTheophylline--2.752023-10-2510.1038/s42004-023-01014-0




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