psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L53	R:R:L57	4.15	No	Yes	0	5	5
2	R:R:L57	R:R:Y61	3.52	Yes	Yes	5	5	8
3	R:R:H114	R:R:L57	7.71	Yes	Yes	5	5	5
4	R:R:I115	R:R:T58	4.56	No	No	0	4	5
5	R:R:L107	R:R:Y61	3.52	No	Yes	0	7	8
6	R:R:R110	R:R:Y61	18.52	Yes	Yes	5	7	8
7	R:R:I111	R:R:Y61	3.63	No	Yes	0	7	8
8	R:R:H114	R:R:Y61	4.36	Yes	Yes	5	5	8
9	R:R:V314	R:R:Y61	5.05	No	Yes	0	5	8
10	R:R:C321	R:R:I64	4.91	No	No	0	7	7
11	R:R:F65	R:R:I66	3.77	Yes	No	0	7	5
12	R:R:F65	R:R:L69	4.87	Yes	No	0	7	6
13	R:R:F65	R:R:L107	3.65	Yes	No	0	7	7
14	R:R:F65	R:R:P108	7.22	Yes	No	0	7	9
15	R:R:C321	R:R:V67	5.12	No	No	0	7	6
16	R:R:G68	R:R:I104	3.53	No	Yes	0	8	5
17	R:R:I73	R:R:L69	2.85	No	No	0	3	6
18	R:R:I104	R:R:L69	4.28	Yes	No	0	5	6
19	R:R:G71	R:R:V70	3.68	No	No	0	8	4
20	R:R:D100	R:R:N72	8.08	Yes	No	2	9	9
21	R:R:I104	R:R:N72	4.25	Yes	No	0	5	9
22	R:R:N72	R:R:Y327	3.49	No	Yes	2	9	9
23	R:R:I73	R:R:L101	2.85	No	No	0	3	7
24	R:R:A75	R:R:Y327	4	No	Yes	0	8	9
25	R:R:I82	R:R:V78	4.61	Yes	No	3	5	7
26	R:R:I334	R:R:V78	4.61	No	No	0	8	7
27	R:R:I337	R:R:V78	6.14	No	No	3	4	7
28	R:R:F79	R:R:L93	4.87	No	Yes	2	6	8
29	R:R:F79	R:R:Y327	5.16	No	Yes	2	6	9
30	R:R:F79	R:R:I334	8.79	No	No	0	6	8
31	R:R:I337	R:R:I82	2.94	No	Yes	3	4	5
32	R:R:H83	R:R:R86	9.03	Yes	Yes	3	5	7
33	R:R:H83	R:R:Q90	11.13	Yes	No	3	5	7
34	R:R:H83	R:R:N333	7.65	Yes	No	0	5	6
35	R:R:Q90	R:R:R86	12.85	No	Yes	3	7	7
36	R:R:L94	R:R:R86	3.64	No	Yes	0	6	7
37	R:R:N87	R:R:Q90	3.96	No	No	0	8	7
38	R:R:S88	R:R:Y92	3.82	No	Yes	6	6	7
39	R:R:D151	R:R:S88	5.89	No	No	0	8	6
40	R:R:S171	R:R:S88	3.26	No	No	6	7	6
41	R:R:I89	R:R:L93	2.85	No	Yes	0	7	8
42	R:R:C175	R:R:I91	3.27	No	No	0	6	6
43	R:R:F147	R:R:Y92	4.13	No	Yes	0	5	7
44	R:R:I148	R:R:Y92	4.84	No	Yes	0	9	7
45	R:R:S171	R:R:Y92	3.82	No	Yes	6	7	7
46	R:R:I148	R:R:L93	2.85	No	Yes	0	9	8
47	R:R:L93	R:R:Y327	7.03	Yes	Yes	2	8	9
48	R:R:C175	R:R:N95	7.87	No	No	0	6	9
49	R:R:N95	R:R:W179	12.43	No	No	0	9	9
50	R:R:D100	R:R:V96	2.92	Yes	No	2	9	9
51	R:R:D323	R:R:V96	4.38	Yes	No	2	9	9
52	R:R:V96	R:R:Y327	5.05	No	Yes	2	9	9
53	R:R:I98	R:R:W179	3.52	No	No	0	5	9
54	R:R:A99	R:R:N137	4.69	No	No	0	8	8
55	R:R:D100	R:R:D323	11.98	Yes	Yes	2	9	9
56	R:R:D100	R:R:Y327	3.45	Yes	Yes	2	9	9
57	R:R:F105	R:R:L101	3.65	No	No	0	5	7
58	R:R:L102	R:R:L133	6.92	No	Yes	0	7	5
59	R:R:F134	R:R:L103	4.87	No	No	0	7	7
60	R:R:L103	R:R:N137	6.87	No	No	0	7	8
61	R:R:L103	R:R:S320	6.01	No	No	0	7	8
62	R:R:I104	R:R:S320	4.64	Yes	No	0	5	8
63	R:R:C106	R:R:L133	4.76	No	Yes	0	6	5
64	R:R:F109	R:R:V130	3.93	No	No	0	6	5
65	R:R:H114	R:R:R110	11.28	Yes	Yes	5	5	7
66	R:R:F205	R:R:R110	6.41	Yes	Yes	0	4	7
67	R:R:E310	R:R:R110	3.49	No	Yes	0	5	7
68	R:R:N118	R:R:Y113	10.47	No	No	0	4	5
69	R:R:W120	R:R:Y113	5.79	Yes	No	0	9	5
70	R:R:F205	R:R:Y113	11.35	Yes	No	0	4	5
71	R:R:K119	R:R:N116	5.6	No	No	0	4	3
72	R:R:L122	R:R:W120	5.69	Yes	Yes	0	7	9
73	R:R:C127	R:R:W120	3.92	No	Yes	7	9	9
74	R:R:C204	R:R:W120	6.53	No	Yes	7	9	9
75	R:R:I125	R:R:T193	3.04	No	No	0	1	5
76	R:R:I125	R:R:L194	2.85	No	No	0	1	4
77	R:R:C127	R:R:C204	7.28	No	No	7	9	9
78	R:R:K128	R:R:T193	13.51	No	No	0	8	5
79	R:R:L133	R:R:V129	2.98	Yes	No	4	5	5
80	R:R:F186	R:R:V129	3.93	Yes	No	4	7	5
81	R:R:F205	R:R:V130	3.93	Yes	No	0	4	5
82	R:R:F186	R:R:T132	3.89	Yes	No	4	7	5
83	R:R:M189	R:R:T132	3.01	No	No	4	4	5
84	L:L:?1	R:R:T132	7.44	Yes	No	4	0	5
85	R:R:F186	R:R:L133	3.65	Yes	Yes	4	7	5
86	R:R:M138	R:R:Y135	3.59	No	No	0	7	5
87	L:L:?1	R:R:Y135	20.72	Yes	No	0	0	5
88	R:R:A182	R:R:M136	3.22	No	No	0	7	5
89	R:R:F186	R:R:M136	3.73	Yes	No	0	7	5
90	R:R:N137	R:R:S141	2.98	No	No	0	8	9
91	R:R:M138	R:R:Y282	5.99	No	Yes	0	7	6
92	R:R:M138	R:R:S316	6.13	No	No	0	7	7
93	R:R:L223	R:R:Y139	14.07	No	No	0	5	7
94	R:R:H283	R:R:Y139	6.53	Yes	No	0	8	7
95	L:L:?1	R:R:Y139	10.85	Yes	No	0	0	7
96	R:R:I140	R:R:V178	3.07	No	No	0	7	7
97	R:R:A182	R:R:I140	3.25	No	No	0	7	7
98	L:L:?1	R:R:I140	3.6	Yes	No	0	0	7
99	R:R:I142	R:R:I230	2.94	No	No	0	8	9
100	R:R:F275	R:R:I142	3.77	Yes	No	0	9	8
101	R:R:F279	R:R:I142	16.33	No	No	0	8	8
102	L:L:?1	R:R:I143	8.41	Yes	No	0	0	5
103	R:R:L145	R:R:V271	4.47	No	No	0	8	7
104	R:R:F147	R:R:V174	5.24	No	No	0	5	5
105	L:L:?1	R:R:F147	4.1	Yes	No	0	0	5
106	R:R:I154	R:R:L150	2.85	No	No	0	6	5
107	R:R:R152	R:R:T264	5.17	No	No	1	9	7
108	R:R:N267	R:R:R152	4.82	Yes	No	1	7	9
109	R:R:M330	R:R:R152	4.96	No	No	1	6	9
110	R:R:I154	R:R:Y153	3.63	No	Yes	0	6	7
111	R:R:N157	R:R:Y153	16.28	No	Yes	1	7	7
112	R:R:K240	R:R:Y153	11.94	No	Yes	1	4	7
113	R:R:I241	R:R:Y153	3.63	No	Yes	0	8	7
114	R:R:I156	R:R:K155	8.72	Yes	No	1	8	8
115	R:R:K155	R:R:Y261	7.17	No	No	1	8	6
116	R:R:K155	R:R:T264	7.51	No	No	1	8	7
117	R:R:I156	R:R:N157	7.08	Yes	No	1	8	7
118	R:R:I156	R:R:I241	4.42	Yes	No	0	8	8
119	R:R:I156	R:R:Y261	8.46	Yes	No	1	8	6
120	R:R:I156	R:R:T264	3.04	Yes	No	1	8	7
121	R:R:K240	R:R:N157	8.39	No	No	1	4	7
122	R:R:I172	R:R:T168	3.04	No	No	0	4	4
123	R:R:K169	R:R:Y173	14.33	No	No	0	4	2
124	L:L:?1	R:R:L181	11.65	Yes	No	0	0	4
125	L:L:?1	R:R:M189	7.14	Yes	No	4	0	4
126	R:R:E216	R:R:K196	5.4	No	No	0	3	3
127	R:R:M203	R:R:S201	4.6	No	No	0	4	4
128	R:R:H206	R:R:M203	3.94	No	No	0	5	4
129	R:R:C204	R:R:F205	4.19	No	Yes	0	9	4
130	R:R:H206	R:R:H306	5.97	No	No	0	5	4
131	R:R:Y207	R:R:Y289	7.94	No	Yes	0	3	4
132	R:R:Q293	R:R:Y207	16.91	No	No	0	4	3
133	R:R:K210	R:R:R208	12.38	Yes	No	0	3	5
134	R:R:D209	R:R:H211	5.04	No	No	0	5	4
135	R:R:A213	R:R:K210	3.21	No	Yes	9	1	3
136	R:R:E216	R:R:K210	8.1	No	Yes	9	3	3
137	R:R:K210	R:R:Q293	8.14	Yes	No	0	3	4
138	R:R:A213	R:R:E216	6.03	No	No	9	1	3
139	R:R:G215	R:R:I218	3.53	No	No	0	3	5
140	R:R:I218	R:R:I222	2.94	No	No	0	5	5
141	R:R:H283	R:R:V224	4.15	Yes	No	0	8	4
142	R:R:F227	R:R:W228	6.01	No	No	0	8	5
143	R:R:F227	R:R:F275	6.43	No	Yes	0	8	9
144	R:R:F227	R:R:H283	26.02	No	Yes	0	8	8
145	R:R:F231	R:R:W228	7.02	Yes	No	0	7	5
146	R:R:F231	R:R:I235	10.05	Yes	No	0	7	4
147	R:R:F231	R:R:F275	7.5	Yes	Yes	0	7	9
148	R:R:F231	R:R:V280	7.87	Yes	No	0	7	5
149	R:R:I234	R:R:S237	3.1	No	No	0	8	6
150	R:R:F275	R:R:I234	7.54	Yes	No	0	9	8
151	R:R:I235	R:R:I239	2.94	No	No	0	4	3
152	R:R:F269	R:R:Y238	9.28	No	No	0	4	8
153	R:R:N267	R:R:T263	4.39	Yes	No	0	7	7
154	R:R:L329	R:R:N267	8.24	Yes	Yes	0	6	7
155	R:R:M330	R:R:N267	4.21	No	Yes	1	6	7
156	R:R:F269	R:R:I273	7.54	No	No	0	4	4
157	R:R:I270	R:R:M326	2.92	No	No	0	5	7
158	R:R:I270	R:R:L329	2.85	No	Yes	0	5	6
159	R:R:I274	R:R:L322	5.71	No	No	0	6	6
160	R:R:I274	R:R:M326	2.92	No	No	0	6	7
161	R:R:T276	R:R:V280	4.76	No	No	0	5	5
162	R:R:C278	R:R:F279	4.19	No	No	8	7	8
163	R:R:C278	R:R:F318	4.19	No	No	0	7	5
164	R:R:C278	R:R:N319	3.15	No	No	8	7	9
165	R:R:F279	R:R:N319	7.25	No	No	8	8	9
166	R:R:P281	R:R:V280	3.53	No	No	0	9	5
167	R:R:H283	R:R:Y282	9.8	Yes	Yes	0	8	6
168	R:R:R286	R:R:Y282	10.29	No	Yes	0	6	6
169	R:R:L313	R:R:Y282	3.52	No	Yes	0	5	6
170	R:R:F285	R:R:I288	6.28	Yes	No	0	5	5
171	R:R:F285	R:R:T308	12.97	Yes	No	0	5	5
172	R:R:R286	R:R:Y289	11.32	No	Yes	0	6	4
173	R:R:N309	R:R:Y289	6.98	No	Yes	0	5	4
174	R:R:S292	R:R:S297	3.26	No	No	10	3	2
175	R:R:S292	R:R:W301	4.94	No	No	10	3	1
176	R:R:N295	R:R:V296	4.43	No	No	0	1	1
177	R:R:S297	R:R:W301	6.18	No	No	10	2	1
178	R:R:K302	R:R:S297	6.12	No	No	0	4	2
179	R:R:C299	R:R:K302	3.23	No	No	0	7	4
180	R:R:I304	R:R:Y300	3.63	No	No	0	3	2
181	R:R:V305	R:R:W301	4.9	No	No	0	4	1
182	R:R:E310	R:R:H306	8.62	No	No	0	5	4
183	R:R:F318	R:R:L322	6.09	No	No	0	5	6
184	R:R:D323	R:R:Y327	4.6	Yes	Yes	2	9	9
185	R:R:M326	R:R:M330	2.89	No	No	0	7	6
186	R:R:F328	R:R:L329	4.87	No	Yes	0	6	6
187	R:R:F328	R:R:R335	11.76	No	No	0	6	8
188	R:R:I334	R:R:S331	4.64	No	No	0	8	8
189	R:R:L122	R:R:M112	2.83	Yes	No	0	7	4
190	R:R:I290	R:R:N220	2.83	No	No	0	5	4
191	R:R:L342	R:R:M338	2.83	No	No	0	5	5
192	R:R:K307	R:R:L53	2.82	No	No	0	3	5
193	R:R:L122	R:R:L126	2.77	Yes	No	0	7	5
194	R:R:L232	R:R:L236	2.77	No	No	0	2	4
195	R:R:H114	R:R:T58	2.74	Yes	No	0	5	5
196	R:R:A97	R:R:Y327	2.67	No	Yes	0	9	9
197	R:R:H83	R:R:I82	2.65	Yes	Yes	3	5	5
198	R:R:F134	R:R:S317	2.64	No	No	0	7	7
199	R:R:F287	R:R:V224	2.62	No	No	0	6	4
200	R:R:S268	R:R:Y238	2.54	No	No	0	7	8
201	R:R:V305	R:R:Y289	2.52	No	Yes	0	4	4
202	R:R:F318	R:R:I64	2.51	No	No	0	5	7
203	R:R:I91	R:R:R86	2.51	No	Yes	0	6	7
204	R:R:F186	R:R:I190	2.51	Yes	No	0	7	5
205	R:R:F285	R:R:M312	2.49	Yes	No	0	5	6
206	R:R:N220	R:R:R286	2.41	No	No	0	4	6
207	R:R:N267	R:R:R266	2.41	Yes	No	0	7	6
208	L:L:?1	R:R:I177	2.4	Yes	No	0	0	3
209	R:R:L144	R:R:Y92	2.34	No	Yes	0	7	7
210	R:R:L272	R:R:Y238	2.34	No	No	0	7	8
211	R:R:G184	R:R:G185	2.11	No	No	0	3	4
212	R:R:G197	R:R:G198	2.11	No	No	0	1	1
213	R:R:F285	R:R:Y289	2.06	Yes	Yes	0	5	4
214	R:R:G71	R:R:P324	2.03	No	No	0	8	9
215	R:R:G146	R:R:S149	1.86	No	No	0	7	9
216	R:R:G131	R:R:V130	1.84	No	No	0	6	5
217	R:R:G185	R:R:T188	1.82	No	No	0	4	8
218	R:R:G81	R:R:I82	1.76	No	Yes	0	4	5
219	R:R:G146	R:R:I234	1.76	No	No	0	7	8
220	R:R:G242	R:R:I241	1.76	No	No	0	4	8
221	R:R:G81	R:R:L80	1.71	No	No	0	4	3
222	R:R:G184	R:R:L183	1.71	No	No	0	3	4
223	R:R:C176	R:R:I172	1.64	No	No	0	4	4
224	R:R:S60	R:R:V314	1.62	No	No	0	5	5
225	R:R:S62	R:R:V63	1.62	No	No	0	6	5
226	R:R:A217	R:R:I290	1.62	No	No	0	4	5
227	R:R:D323	R:R:P324	1.61	Yes	No	0	9	9
228	R:R:S62	R:R:T59	1.6	No	No	0	6	5
229	R:R:V63	R:R:V67	1.6	No	No	0	5	6
230	R:R:S171	R:R:T168	1.6	No	No	0	7	4
231	R:R:T55	R:R:V56	1.59	No	No	0	5	5
232	R:R:T193	R:R:V124	1.59	No	No	0	5	4
233	R:R:A97	R:R:L76	1.58	No	No	0	9	7
234	R:R:A217	R:R:L294	1.58	No	No	0	4	1
235	R:R:T167	R:R:T168	1.57	No	No	0	6	4
236	R:R:A213	R:R:N212	1.56	No	No	0	1	2
237	R:R:I311	R:R:V56	1.54	No	No	0	5	5
238	R:R:I74	R:R:V70	1.54	No	No	0	5	4
239	R:R:I125	R:R:V129	1.54	No	No	0	1	5
240	R:R:I277	R:R:T276	1.52	No	No	0	5	5
241	R:R:I304	R:R:T308	1.52	No	No	0	3	5
242	R:R:N118	R:R:S54	1.49	No	No	0	4	5
243	R:R:L229	R:R:V225	1.49	No	No	0	5	5
244	R:R:L329	R:R:V325	1.49	Yes	No	0	6	6
245	R:R:N333	R:R:S332	1.49	No	No	0	6	5
246	R:R:L122	R:R:T121	1.47	Yes	No	0	7	3
247	R:R:L192	R:R:T188	1.47	No	No	0	4	8
248	R:R:I270	R:R:I273	1.47	No	No	0	5	4
249	R:R:I273	R:R:I277	1.47	No	No	0	4	5
250	R:R:I172	R:R:K169	1.45	No	No	0	4	4
251	R:R:I191	R:R:K195	1.45	No	No	0	4	4
252	L:L:?1	R:R:G185	1.44	Yes	No	0	0	4
253	R:R:I311	R:R:L57	1.43	No	Yes	0	5	5
254	R:R:I274	R:R:L145	1.43	No	No	0	6	8
255	R:R:K51	R:R:L52	1.41	No	No	0	4	4
256	R:R:K214	R:R:L294	1.41	No	No	0	2	1
257	R:R:L232	R:R:L233	1.38	No	No	0	2	7
258	R:R:E303	R:R:K307	1.35	No	No	0	1	3
259	R:R:N116	R:R:Q117	1.32	No	No	0	3	3
260	R:R:D209	R:R:Q293	1.31	No	No	0	5	4
261	R:R:A284	R:R:W228	1.3	No	No	0	6	5
262	R:R:S298	R:R:Y300	1.27	No	No	0	5	2
263	R:R:F328	R:R:M338	1.24	No	No	0	6	5
264	R:R:F186	R:R:L187	1.22	Yes	No	0	7	4
265	R:R:F343	R:R:L342	1.22	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L57	4.2025	4	5	5
2	R:R:Y61	6.43333	6	5	8
3	R:R:F65	4.8775	4	0	7
4	R:R:I82	2.99	4	3	5
5	R:R:H83	7.615	4	3	5
6	R:R:R86	7.0075	4	3	7
7	R:R:Y92	3.79	5	6	7
8	R:R:L93	4.4	4	2	8
9	R:R:D100	6.6075	4	2	9
10	R:R:I104	4.175	4	0	5
11	R:R:R110	9.925	4	5	7
12	R:R:H114	6.5225	4	5	5
13	R:R:W120	5.4825	4	7	9
14	R:R:L122	3.19	4	0	7
15	R:R:L133	4.5775	4	4	5
16	R:R:Y153	8.87	4	1	7
17	R:R:I156	6.344	5	1	8
18	R:R:F186	3.155	6	4	7
19	R:R:F205	6.47	4	0	4
20	R:R:K210	7.9575	4	9	3
21	R:R:F231	8.11	4	0	7
22	R:R:N267	4.814	5	1	7
23	R:R:F275	6.31	4	0	9
24	R:R:Y282	7.4	4	0	6
25	R:R:H283	11.625	4	0	8
26	R:R:F285	5.95	4	0	5
27	R:R:Y289	6.164	5	0	4
28	R:R:D323	5.6425	4	2	9
29	R:R:Y327	4.43125	8	2	9
30	R:R:L329	4.3625	4	0	6
31	L:L:?1	7.775	10	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L107	R:R:Y61	46.9572	3.52	No	Yes	0	7	8
2	R:R:R110	R:R:Y61	31.1382	18.52	Yes	Yes	5	7	8
3	R:R:C278	R:R:F318	20.4658	4.19	No	No	0	7	5
4	R:R:C278	R:R:F279	20.8527	4.19	No	No	8	7	8
5	R:R:F279	R:R:I142	22.1488	16.33	No	No	0	8	8
6	R:R:F275	R:R:I142	23.3584	3.77	Yes	No	0	9	8
7	R:R:F227	R:R:F275	62.0849	6.43	No	Yes	0	8	9
8	R:R:F227	R:R:H283	100	26.02	No	Yes	0	8	8
9	R:R:H283	R:R:Y139	95.4508	6.53	Yes	No	0	8	7
10	L:L:?1	R:R:Y139	94.9662	10.85	Yes	No	0	0	7
11	L:L:?1	R:R:F147	98.7603	4.1	Yes	No	0	0	5
12	R:R:F147	R:R:Y92	97.8625	4.13	No	Yes	0	5	7
13	R:R:I148	R:R:Y92	90.9993	4.84	No	Yes	0	9	7
14	R:R:I148	R:R:L93	90.2742	2.85	No	Yes	0	9	8
15	R:R:L93	R:R:Y327	68.5875	7.03	Yes	Yes	2	8	9
16	R:R:N72	R:R:Y327	63.689	3.49	No	Yes	2	9	9
17	R:R:I104	R:R:N72	64.3914	4.25	Yes	No	0	5	9
18	R:R:I104	R:R:L69	55.432	4.28	Yes	No	0	5	6
19	R:R:F65	R:R:L69	51.2547	4.87	Yes	No	0	7	6
20	R:R:F65	R:R:L107	48.0428	3.65	Yes	No	0	7	7
21	R:R:I82	R:R:V78	19.3238	4.61	Yes	No	3	5	7
22	R:R:I334	R:R:V78	21.8595	4.61	No	No	0	8	7
23	R:R:F79	R:R:I334	24.0947	8.79	No	No	0	6	8
24	R:R:H83	R:R:I82	15.5898	2.65	Yes	Yes	3	5	5
25	R:R:F186	R:R:T132	16.7168	3.89	Yes	No	4	7	5
26	L:L:?1	R:R:T132	17.9151	7.44	Yes	No	4	0	5
27	R:R:F205	R:R:R110	25.2029	6.41	Yes	Yes	0	4	7
28	R:R:F205	R:R:Y113	10.8189	11.35	Yes	No	0	4	5
29	R:R:L122	R:R:W120	10.9053	5.69	Yes	Yes	0	7	9
30	L:L:?1	R:R:Y135	18.1104	20.72	Yes	No	0	0	5
31	R:R:M138	R:R:Y135	17.7385	3.59	No	No	0	7	5
32	R:R:M138	R:R:Y282	18.1593	5.99	No	Yes	0	7	6
33	R:R:H283	R:R:Y282	37.2276	9.8	Yes	Yes	0	8	6
34	R:R:I274	R:R:L322	15.7889	5.71	No	No	0	6	6
35	R:R:F318	R:R:L322	16.3899	6.09	No	No	0	5	6
36	R:R:I154	R:R:Y153	14.3539	3.63	No	Yes	0	6	7
37	R:R:N157	R:R:Y153	10.7551	16.28	No	Yes	1	7	7
38	R:R:I156	R:R:N157	17.4606	7.08	Yes	No	1	8	7
39	R:R:I156	R:R:T264	41.9346	3.04	Yes	No	1	8	7
40	R:R:R152	R:R:T264	52.3291	5.17	No	No	1	9	7
41	R:R:N267	R:R:R152	22.3929	4.82	Yes	No	1	7	9
42	R:R:L329	R:R:N267	26.4801	8.24	Yes	Yes	0	6	7
43	R:R:I270	R:R:L329	35.9391	2.85	No	Yes	0	5	6
44	R:R:I270	R:R:I273	61.4275	1.47	No	No	0	5	4
45	R:R:I273	R:R:I277	67.0849	1.47	No	No	0	4	5
46	R:R:I277	R:R:T276	68.2344	1.52	No	No	0	5	5
47	R:R:T276	R:R:V280	69.4065	4.76	No	No	0	5	5
48	R:R:F231	R:R:V280	71.7881	7.87	Yes	No	0	7	5
49	R:R:F231	R:R:W228	37.2915	7.02	Yes	No	0	7	5
50	R:R:F227	R:R:W228	38.1555	6.01	No	No	0	8	5
51	R:R:I241	R:R:Y153	10.7739	3.63	No	Yes	0	8	7
52	R:R:I156	R:R:I241	17.4606	4.42	Yes	No	0	8	8
53	R:R:M330	R:R:R152	33.2231	4.96	No	No	1	6	9
54	R:R:M326	R:R:M330	35.3306	2.89	No	No	0	7	6
55	R:R:I270	R:R:M326	25.1653	2.92	No	No	0	5	7
56	R:R:F231	R:R:F275	38.3696	7.5	Yes	Yes	0	7	9
57	R:R:I274	R:R:M326	13.9594	2.92	No	No	0	6	7
58	R:R:Q293	R:R:Y207	15.0075	16.91	No	No	0	4	3
59	R:R:Y207	R:R:Y289	16.4087	7.94	No	Yes	0	3	4
60	R:R:R286	R:R:Y289	39.737	11.32	No	Yes	0	6	4
61	R:R:R286	R:R:Y282	48.8655	10.29	No	Yes	0	6	6
62	R:R:F285	R:R:Y289	11.6304	2.06	Yes	Yes	0	5	4
63	R:R:F79	R:R:L93	20.2442	4.87	No	Yes	2	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F147	R:R:Y92	4.13	0	No	Yes	5	7	1	2
R:R:F186	R:R:T132	3.89	4	Yes	No	7	5	2	1
R:R:M189	R:R:T132	3.01	4	No	No	4	5	1	1
L:L:?1	R:R:T132	7.44	4	Yes	No	0	5	0	1
R:R:M138	R:R:Y135	3.59	0	No	No	7	5	2	1
L:L:?1	R:R:Y135	20.72	4	Yes	No	0	5	0	1
R:R:L223	R:R:Y139	14.07	0	No	No	5	7	2	1
R:R:H283	R:R:Y139	6.53	0	Yes	No	8	7	2	1
L:L:?1	R:R:Y139	10.85	4	Yes	No	0	7	0	1
R:R:I140	R:R:V178	3.07	0	No	No	7	7	1	2
R:R:A182	R:R:I140	3.25	0	No	No	7	7	2	1
L:L:?1	R:R:I140	3.6	4	Yes	No	0	7	0	1
L:L:?1	R:R:I143	8.41	4	Yes	No	0	5	0	1
R:R:F147	R:R:V174	5.24	0	No	No	5	5	1	2
L:L:?1	R:R:F147	4.1	4	Yes	No	0	5	0	1
L:L:?1	R:R:L181	11.65	4	Yes	No	0	4	0	1
L:L:?1	R:R:M189	7.14	4	Yes	No	0	4	0	1
L:L:?1	R:R:I177	2.4	4	Yes	No	0	3	0	1
R:R:G184	R:R:G185	2.11	0	No	No	3	4	2	1
R:R:G185	R:R:T188	1.82	0	No	No	4	8	1	2
L:L:?1	R:R:G185	1.44	4	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
30.00	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
25.00	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
25.00	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
22.73	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
22.73	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
22.22	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
22.22	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
22.22	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
21.43	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
21.05	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
21.05	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
21.05	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
20.00	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
19.05	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
19.05	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
18.75	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
18.75	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
18.75	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
18.75	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
18.18	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
17.39	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
17.39	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
16.67	Single	5KW2	PubChem 133053953	5KW2-FFA1 (GPR40)-PubChem 133053953
16.67	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
16.67	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
16.67	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Consensus	c5a1_off_ortoallo	Other Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
16.67	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.79	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
15.79	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
15.38	Single	5XSZ	Glyceryl Mono-oleate	5XSZ-LPA₆-Glyceryl Mono-oleate
15.38	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
15.38	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
15.00	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
15.00	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
15.00	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
15.00	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
14.81	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29	Single	2HPY	All-trans-retinal	2HPY-Rhodopsin-All-trans-retinal
14.29	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
14.29	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
14.29	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
14.29	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
14.29	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
14.29	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
14.29	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
14.29	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.64	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
13.64	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.64	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.64	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
13.64	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
13.64	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
13.33	Single	6FUF	All-trans-retinal	6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
13.33	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
13.33	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.33	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
13.33	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.33	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.04	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
12.50	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
12.50	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
12.50	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
12.50	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
12.50	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
12.50	Single	7CKZ	Mevidalen	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
12.50	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
12.50	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.50	Single	8ITF	DMCHA	8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
12.50	Consensus	mt2_on	Orthosteric Ligand	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
12.00	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
11.76	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
11.76	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
11.76	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
11.76	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
11.76	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
11.76	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
11.76	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
11.76	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
11.76	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.76	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
11.76	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
11.76	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
11.76	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
11.76	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.76	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
11.76	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.11	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
11.11	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
11.11	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
11.11	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
11.11	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
11.11	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.11	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
11.11	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
11.11	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
11.11	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
11.11	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
11.11	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
11.11	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.11	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
11.11	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
11.11	Consensus	sensory_off	Orthosteric Ligand	opsin_off
10.53	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
10.53	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
10.53	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
10.53	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
10.53	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
10.53	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
10.53	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
10.53	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
10.53	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
10.53	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
10.53	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
10.53	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
10.53	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
10.53	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
10.53	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
10.53	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
10.53	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
10.53	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
10.53	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
10.53	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
10.53	Consensus	blt_on	Orthosteric Ligand	blt1_on
10.53	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
10.53	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
10.53	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
10.53	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
10.53	Consensus	leuko_on	Orthosteric Ligand	blt_on
10.53	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.53	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.53	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
10.53	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
10.00	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
10.00	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
10.00	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
10.00	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
10.00	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
10.00	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.00	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
10.00	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
10.00	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
10.00	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
10.00	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
10.00	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
9.52	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
9.52	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
9.52	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
9.52	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
9.52	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
9.52	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
9.52	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
9.52	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.52	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
9.52	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
9.52	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
9.52	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
9.52	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
9.52	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
9.52	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
9.52	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
9.52	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
9.52	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
9.52	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
9.52	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
9.52	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
9.52	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
9.52	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
9.52	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
9.52	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
9.52	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
9.52	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
9.52	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
9.09	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
9.09	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
9.09	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
9.09	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
9.09	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
9.09	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
9.09	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
9.09	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
9.09	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
9.09	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
9.09	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
9.09	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
9.09	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
9.09	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
9.09	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
9.09	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
9.09	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
9.09	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
9.09	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
9.09	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
9.09	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
9.09	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
9.09	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
8.70	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
8.70	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
8.70	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
8.70	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
8.70	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
8.70	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
8.70	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
8.70	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
8.70	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
8.70	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
8.70	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
8.70	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
8.70	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
8.70	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
8.70	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
8.70	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
8.70	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
8.33	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.33	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
8.33	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
8.33	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
8.33	Consensus	class-d_off	Orthosteric Ligand	ste2_off
8.33	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
8.33	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.33	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
8.00	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
8.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
8.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
8.00	Single	7QA8	Peptide	7QA8-STE2-Peptide
8.00	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
8.00	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
8.00	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
8.00	Consensus	class-d_off	Orthosteric Ligand	ste2_off
8.00	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
7.69	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
7.69	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
7.69	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8WCC	Cyclohexylammonium ion	8WCC-TA1-Cyclohexylammonium ion
7.69	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
7.69	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
7.41	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
7.41	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
7.41	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
7.41	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
7.41	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
7.41	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
7.41	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
7.14	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.14	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
7.14	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
7.14	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
7.14	Single	8GEJ	Epinephrine	8GEJ-β₂-Epinephrine-Gs/&β;1/&γ;2
7.14	Consensus	class-d_on	Orthosteric Ligand	ste2_on
7.14	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
7.14	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.14	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
6.90	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
6.67	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
6.67	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
6.67	Single	7Y14	Beta-alanine	7Y14-MRGPRD-Beta-alanine
6.67	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8IWM	2-Phenylethylamine	8IWM-TAAR9-2-Phenylethylamine
6.67	Consensus	class-d_on	Orthosteric Ligand	ste2_on
6.45	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.45	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
6.45	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
6.45	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
6.45	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.25	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
6.25	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
6.25	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
6.25	Single	3PQR	All-trans-retinal	3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
6.25	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
6.25	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
6.25	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
6.25	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
6.25	Single	6OBA	GTPL11074	6OBA-β₂-(S)-Alprenolol-GTPL11074
6.25	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
6.25	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.25	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
6.25	Single	7Y12	Beta-alanine	7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.25	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8GGR	Epinephrine	8GGR-β₂-Epinephrine
6.25	Single	8GGZ	Epinephrine	8GGZ-β₂-Epinephrine
6.25	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
6.25	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
6.25	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/&β;1/&γ;2
6.25	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
6.25	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	beta2_off_allo	Other Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
6.25	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
6.25	Consensus	opsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.88	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
5.88	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
5.88	Single	5NDZ	AZ3451; Na	5NDZ-PAR2-AZ3451; Na
5.88	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
5.88	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
5.88	Single	6HLL	CP99994	6HLL-NK₁-CP99994
5.88	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
5.88	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
5.88	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
5.88	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
5.88	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2
5.88	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.88	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
5.88	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
5.88	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
5.88	Single	8GEI	Epinephrine	8GEI-β₂-Epinephrine-Gs/&β;1/&γ;2
5.88	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8GGS	Epinephrine	8GGS-β₂-Epinephrine
5.88	Single	8GGY	Epinephrine	8GGY-β₂-Epinephrine
5.88	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
5.88	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
5.88	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
5.88	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88	Single	8UNV	Epinephrine	8UNV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
5.88	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.88	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
5.56	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
5.56	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
5.56	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
5.56	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
5.56	Single	6AKX	A4R	6AKX-CCR5-A4R
5.56	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
5.56	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
5.56	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.56	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
5.56	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
5.56	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.56	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.56	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
5.56	Single	6OYA	All-trans-retinal	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.56	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
5.56	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
5.56	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
5.56	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
5.56	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
5.56	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
5.56	Single	7WV9	ZCZ011	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.56	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
5.56	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.56	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
5.56	Single	8G2Y	LPC	8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	8GEC	Epinephrine	8GEC-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Single	8GEF	Epinephrine	8GEF-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Single	8GG7	Epinephrine	8GG7-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8GGA	Epinephrine	8GGA-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8GGV	Epinephrine	8GGV-β₂-Epinephrine
5.56	Single	8GGW	Epinephrine	8GGW-β₂-Epinephrine
5.56	Single	8GGX	Epinephrine	8GGX-β₂-Epinephrine
5.56	Single	8GH0	Epinephrine	8GH0-β₂-Epinephrine
5.56	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
5.56	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
5.56	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.56	Single	8UNO	Epinephrine	8UNO-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
5.56	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56	Consensus	5ht2_on	Orthosteric Ligand	5ht2a_on 5ht2c_on
5.56	Consensus	5ht2c_on	Orthosteric Ligand	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.56	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
5.56	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
5.56	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
5.56	Consensus	alpha2a_off	Orthosteric Ligand	6KUX-α_2a-RS-79948
5.56	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
5.56	Consensus	cb1_on_allo	Other Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.56	Consensus	d1_on_allo	Other Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.56	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
5.56	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
5.56	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	gt_class-a	Orthosteric Ligand	gt_opsin
5.56	Consensus	gt_opsin	Orthosteric Ligand	gt_sensory
5.56	Consensus	gt_sensory	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.56	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
5.56	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.26	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
5.26	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
5.26	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
5.26	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
5.26	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
5.26	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
5.26	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
5.26	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
5.26	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
5.26	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.26	Single	6IQL	L745870	6IQL-D₄-L745870
5.26	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
5.26	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
5.26	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
5.26	Single	6N48	PubChem 138454256	6N48-β₂-BI167107-PubChem 138454256
5.26	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.26	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
5.26	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
5.26	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
5.26	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
5.26	Single	6VI4	JDTic	6VI4-κ-JDTic
5.26	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
5.26	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
5.26	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
5.26	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.26	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
5.26	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
5.26	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
5.26	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
5.26	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
5.26	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7T32	ZM241385	7T32-A_2A-ZM241385
5.26	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.26	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
5.26	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
5.26	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
5.26	Single	7WU3	K6G	7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
5.26	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.26	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE1	Epinephrine	8GE1-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE4	Epinephrine	8GE4-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE6	Epinephrine	8GE6-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE7	Epinephrine	8GE7-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE8	Epinephrine	8GE8-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE9	Epinephrine	8GE9-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GFV	Epinephrine	8GFV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GG4	Epinephrine	8GG4-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GGI	Epinephrine	8GGI-β₂-Epinephrine
5.26	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
5.26	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
5.26	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
5.26	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
5.26	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
5.26	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
5.26	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
5.26	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
5.26	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
5.26	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
5.26	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
5.26	Single	8UNQ	Epinephrine	8UNQ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
5.26	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
5.26	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
5.26	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
5.26	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
5.26	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.26	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
5.26	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
5.26	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
5.26	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
5.26	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
5.26	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
5.13	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.00	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
5.00	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
5.00	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.00	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
5.00	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
5.00	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
5.00	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
5.00	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
5.00	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
5.00	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
5.00	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
5.00	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.00	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
5.00	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.00	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
5.00	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
5.00	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
5.00	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
5.00	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
5.00	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
5.00	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
5.00	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
5.00	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
5.00	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
5.00	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
5.00	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
5.00	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
5.00	Single	6GPS	MK0812	6GPS-CCR2-MK0812
5.00	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
5.00	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
5.00	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
5.00	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
5.00	Single	6PS1	Timolol	6PS1-β₂-Timolol
5.00	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
5.00	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.00	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
5.00	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
5.00	Single	7BU7	BI167107	7BU7-β₁-BI167107
5.00	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
5.00	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
5.00	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.00	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
5.00	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
5.00	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
5.00	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
5.00	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
5.00	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
5.00	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
5.00	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
5.00	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
5.00	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
5.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.00	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
5.00	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
5.00	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
5.00	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
5.00	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
5.00	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
5.00	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
5.00	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
5.00	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
5.00	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
5.00	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
5.00	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
5.00	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.00	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
5.00	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.00	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
5.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.00	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
5.00	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
5.00	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
5.00	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
5.00	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
5.00	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
5.00	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.00	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
5.00	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
5.00	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
5.00	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
5.00	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
5.00	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
5.00	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.00	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
5.00	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.00	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
5.00	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
5.00	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
5.00	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
5.00	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
5.00	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
5.00	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
5.00	Consensus	tar_on	Orthosteric Ligand	ta1_on
4.76	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
4.76	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
4.76	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
4.76	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
4.76	Single	5C1M	BU72	5C1M-μ-BU72
4.76	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
4.76	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
4.76	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
4.76	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
4.76	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
4.76	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
4.76	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
4.76	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
4.76	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
4.76	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
4.76	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
4.76	Single	6GPX	MK0812	6GPX-CCR2-MK0812
4.76	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
4.76	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
4.76	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
4.76	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
4.76	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
4.76	Single	6PS6	Timolol	6PS6-β₂-Timolol
4.76	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
4.76	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
4.76	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
4.76	Single	7C4S	S1P	7C4S-S1P₃-S1P
4.76	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
4.76	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
4.76	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
4.76	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
4.76	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.76	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
4.76	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
4.76	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
4.76	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
4.76	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
4.76	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
4.76	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
4.76	Single	7WU5	K6G	7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
4.76	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
4.76	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
4.76	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
4.76	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
4.76	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.76	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
4.76	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
4.76	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
4.76	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
4.76	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
4.76	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
4.76	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
4.76	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
4.76	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
4.76	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.76	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.76	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.76	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.76	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
4.76	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
4.76	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
4.76	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
4.76	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
4.76	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
4.76	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
4.76	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
4.76	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
4.76	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
4.76	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
4.76	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
4.76	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
4.76	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
4.76	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
4.76	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
4.76	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
4.76	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
4.76	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	2YDV	NECA	2YDV-A_2A-NECA
4.55	Single	3P0G	BI167107	3P0G-β₂-BI167107
4.55	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
4.55	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
4.55	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
4.55	Single	4DJH	JDTic	4DJH-κ-JDTic
4.55	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
4.55	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
4.55	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
4.55	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
4.55	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
4.55	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
4.55	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
4.55	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
4.55	Single	5G53	NECA	5G53-A_2A-NECA-Gs
4.55	Single	5X93	K-8794	5X93-ET_B-K-8794
4.55	Single	5XR8	AM841	5XR8-CB₁-AM841
4.55	Single	5XRA	AM11542	5XRA-CB₁-AM11542
4.55	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
4.55	Single	6E59	L-760735	6E59-NK₁-L-760735
4.55	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
4.55	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
4.55	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
4.55	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
4.55	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
4.55	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
4.55	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
4.55	Single	6OS1	TRV026	6OS1-AT₁-TRV026
4.55	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
4.55	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
4.55	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
4.55	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.55	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
4.55	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
4.55	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
4.55	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
4.55	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
4.55	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
4.55	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
4.55	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
4.55	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.55	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
4.55	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
4.55	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
4.55	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
4.55	Single	7WU4	K6G	7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
4.55	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.55	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
4.55	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
4.55	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
4.55	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
4.55	Single	8E0G	BU72	8E0G-μ-BU72
4.55	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
4.55	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.55	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
4.55	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
4.55	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
4.55	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
4.55	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.55	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
4.55	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
4.55	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
4.55	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
4.55	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
4.55	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.55	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
4.55	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
4.55	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
4.55	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
4.55	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
4.55	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
4.55	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
4.55	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
4.55	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
4.55	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
4.55	Consensus	histamine_off	Orthosteric Ligand	h1_off
4.55	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
4.55	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
4.55	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
4.55	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
4.55	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.55	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
4.55	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.55	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
4.35	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.35	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.35	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.35	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
4.35	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.35	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.35	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.35	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
4.35	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.35	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
4.35	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
4.35	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
4.35	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
4.35	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.35	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
4.35	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
4.35	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
4.35	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.35	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.35	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
4.35	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
4.35	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
4.35	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
4.35	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
4.35	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
4.35	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
4.35	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.35	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
4.35	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
4.35	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
4.35	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
4.35	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
4.35	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
4.35	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
4.35	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
4.35	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
4.35	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
4.35	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
4.35	Consensus	dp_off	Orthosteric Ligand	dp2_off
4.35	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
4.35	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.35	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
4.35	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
4.35	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
4.35	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
4.35	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.35	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
4.35	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
4.35	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.17	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.17	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
4.17	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.17	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
4.17	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
4.17	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
4.17	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.17	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.17	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
4.17	Single	7EZC	UKA	7EZC-A_2A-UKA
4.17	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.17	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
4.17	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
4.17	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
4.17	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
4.17	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.17	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
4.17	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
4.17	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
4.17	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.17	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
4.17	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.17	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
4.17	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
4.17	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
4.17	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
4.17	Consensus	endothelin_off	Orthosteric Ligand	etb_off
4.17	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
4.17	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
4.17	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
4.17	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	orexin_on	Orthosteric Ligand	ox2_on
4.17	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
4.00	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
4.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
4.00	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
4.00	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
4.00	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
4.00	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
4.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
4.00	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
4.00	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.00	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
4.00	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
4.00	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
4.00	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.00	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
4.00	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
4.00	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
4.00	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
4.00	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
3.85	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
3.85	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
3.85	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
3.85	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
3.85	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
3.85	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
3.85	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
3.85	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
3.85	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
3.85	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.85	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
3.85	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
3.85	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
3.85	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
3.85	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
3.85	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
3.85	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
3.70	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
3.70	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
3.70	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.70	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
3.70	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
3.70	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
3.70	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
3.70	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
3.70	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
3.70	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
3.70	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
3.70	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
3.70	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
3.57	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
3.57	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
3.57	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
3.57	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
3.57	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
3.57	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
3.57	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
3.57	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
3.57	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
3.57	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
3.57	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
3.57	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
3.57	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
3.57	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
3.45	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.45	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
3.45	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.45	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
3.45	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
3.45	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
3.45	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
3.45	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
3.45	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
3.45	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.45	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.33	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.33	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
3.33	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
3.33	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
3.33	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
3.33	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.33	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.33	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
3.33	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
3.33	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.33	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
3.33	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
3.33	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
3.33	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.33	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.23	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
3.23	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
3.23	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.23	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
3.23	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.23	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
3.23	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
3.23	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
3.23	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.23	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.23	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
3.23	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.23	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.23	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
3.23	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
3.12	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
3.12	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
3.12	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.12	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.12	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
3.12	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
3.12	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
3.12	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.12	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.12	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.12	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
3.12	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.12	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.12	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
3.12	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.12	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.12	Consensus	go_class-b1	Orthosteric Ligand	go_crf
3.12	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.12	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.12	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.03	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
3.03	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
3.03	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
3.03	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
3.03	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.03	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.03	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
3.03	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.03	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
3.03	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
3.03	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
3.03	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
3.03	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.03	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.03	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
3.03	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.03	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
3.03	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
3.03	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.03	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
2.94	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
2.94	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
2.94	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
2.94	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
2.94	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
2.94	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
2.94	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.94	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
2.94	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
2.94	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.94	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
2.86	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
2.86	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.86	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
2.86	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.86	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
2.86	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.86	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.86	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
2.86	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
2.78	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
2.78	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
2.78	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.78	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
2.78	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.78	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
2.78	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.70	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
2.70	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
2.70	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.70	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.70	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
2.70	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.70	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.70	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
2.63	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.63	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.63	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
2.50	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
2.50	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.44	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
2.44	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.33	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.33	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf

PDB Summary
PDB	8IYX
Class	A
SubFamily	Orphan
Type	A orphans
SubType	GPR34
Species	Homo sapiens
Ligand	YL-365
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.34
Date	2024-03-20
D.O.I.	10.1073/pnas.2308435120

Net Summary
I_min	2.85
Number of Linked Nodes	247
Number of Links	265
Number of Hubs	31
Number of Links mediated by Hubs	124
Number of Communities	10
Number of Nodes involved in Communities	48
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	48159
Length Of Smallest Path	3
Average Path Length	17.8005
Length of Longest Path	37
Minimum Path Strength	1.47
Average Path Strength	6.20834
Maximum Path Strength	17.91
Minimum Path Correlation	0.7
Average Path Correlation	0.924434
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	33.3289
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.8663
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	S6R
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	S6R
Name	1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid
Synonyms
Identifier	1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid
Formula	C34 H31 Cl N2 O5
Molecular Weight	583.073
SMILES	c1ccc(cc1)COc2ccc(cc2)CC(=O)NC3(CCN(CC3)C(=O)c4ccc(cc4)c5cccc(c5)Cl)C(=O)O
PubChem	169422747
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	0
Total Bonds	77
Total Aromatic Bonds	24


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UPC5
Sequence	>8IYX_Chain_R K L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H R K R N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q N K W T L G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N T T K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G G H N S T M C F H Y R D K H N A K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S Q L N V S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N I R K I M C Q L L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IYX	A	Orphan	A orphans	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	10.1073/pnas.2308435120
	8IZ4	A	Orphan	A orphans	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/&β;1/&γ;2	2.94	2024-04-10	To be published
	8K4N	A	Orphan	A orphans	GPR34	Homo sapiens	VF0	-	Gi1/&β;1/&γ;2	2.83	2023-10-25	To be published
	8SAI	A	Orphan	A orphans	GPR34	Homo sapiens	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	-	Gi1/&β;1/&γ;2	3.27	2023-10-04	10.1073/pnas.2308435120
	8WRB	A	Orphan	A orphans	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/&β;1/&γ;2	2.91	2023-11-08	10.1371/journal.pbio.3002387
	8XBH	A	Orphan	A orphans	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/&β;1/&γ;2	2.83	2023-12-27	To be published
	8XBI	A	Orphan	A orphans	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.06	2023-12-27	To be published

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