Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 8.2054174
2A:A:L44 6.9175429
3A:A:L46 2.89428
4A:A:I207 3.94429
5A:A:F212 3.84539
6A:A:V217 5.935435
7A:A:F219 4.436538
8A:A:M221 3.8475438
9A:A:V224 3.3925429
10A:A:K233 7.45429
11A:A:W234 4.928529
12A:A:F238 7.17629
13A:A:I244 4.4025428
14A:A:F246 2.87409
15A:A:N264 4.064189
16A:A:Q267 2.54254184
17A:A:L272 2.91408
18A:A:F273 5.9525479
19A:A:W277 6.34167676
20A:A:W281 7.942525
21A:A:I288 2.97439
22A:A:F290 2.7575439
23A:A:F312 4.89754188
24A:A:Y318 3.898506
25A:A:E330 4.5525403
26A:A:F340 9.4375407
27A:A:L346 2.97474
28A:A:I348 4.7325404
29A:A:D354 7.3025473
30A:A:R356 6.66472
31A:A:C359 3.2475475
32A:A:Y360 7.27638
33A:A:F376 5.86438
34A:A:R380 2.8925437
35A:A:R385 7.294535
36A:A:Y391 4.37664
37B:B:Q6 1.6025401
38B:B:I18 2.655447
39B:B:L51 7.575409
40B:B:H54 7.054519
41B:B:K57 9.85429
42B:B:Y59 7.505428
43B:B:W63 4.07617
44B:B:R68 9.755415
45B:B:Q75 4.972529
46B:B:D76 5.811676179
47B:B:K78 5.785408
48B:B:L79 3.005407
49B:B:I81 3.295417
50B:B:W82 11.002519
51B:B:D83 5.368518
52B:B:K89 6.924519
53B:B:I93 5.975417
54B:B:W99 8.326529
55B:B:Y105 4.775256
56B:B:C114 3.5425418
57B:B:Y124 4.38333616
58B:B:H142 7.66667699
59B:B:Y145 4.635828
60B:B:L146 3.665497
61B:B:R150 5.0354196
62B:B:F151 5.9125409
63B:B:S160 4.44754196
64B:B:S161 7.285499
65B:B:D163 7.89499
66B:B:W169 9.78598
67B:B:D170 4.84754289
68B:B:F180 6.6785127
69B:B:H183 5.5665129
70B:B:L190 2.8954195
71B:B:S201 4.6745129
72B:B:K209 6.2354126
73B:B:L210 5.7075405
74B:B:W211 9.078336128
75B:B:Q220 6.755447
76B:B:F222 6.89667648
77B:B:H225 9.63833649
78B:B:D228 4.14529
79B:B:F235 7.1156106
80B:B:P236 5.68254107
81B:B:N237 10.9654105
82B:B:F241 5.47714746
83B:B:T243 6.47448
84B:B:D247 5.9675409
85B:B:R251 8.046548
86B:B:F253 7.695646
87B:B:D258 10.115447
88B:B:Y264 4.13429705
89B:B:V276 3.67406
90B:B:F278 4.726676107
91B:B:R283 9.6945119
92B:B:L284 3.864115
93B:B:L285 4.71254106
94B:B:Y289 5.8656137
95B:B:W297 7.9354138
96B:B:K301 5.565115
97B:B:R304 9.254135
98B:B:L308 10.3054167
99B:B:R314 12.4675428
100B:B:T321 4.704517
101B:B:M325 5.736515
102B:B:W332 10.905629
103B:B:K337 10.4854166
104B:B:W339 11.3565169
105B:B:N340 6.4375419
106G:G:E22 5.04449
107G:G:R27 7.158548
108G:G:K29 5.10254154
109G:G:Y40 10.69754106
110G:G:L51 4.826676116
111G:G:N59 5.1775419
112G:G:F61 6.33571718
113L:L:H1 4.78167650
114L:L:D3 5.12550
115L:L:F6 3.89667650
116L:L:L13 4.725400
117L:L:V27 5.055480
118R:R:L31 4.31404
119R:R:R51 2.21254322
120R:R:E52 4.08754323
121R:R:W70 7.775317
122R:R:I73 4.928585
123R:R:P81 6.3625404
124R:R:C89 4.33254219
125R:R:F92 8.774305
126R:R:L103 3.63254217
127R:R:R105 10.356588
128R:R:G111 2.5575409
129R:R:W112 19.4275489
130R:R:T115 4.0525484
131R:R:F116 12.44584
132R:R:L121 2.6125485
133R:R:L139 3.27454
134R:R:Y146 4.25857757
135R:R:Y150 5.956557
136R:R:R174 6.412569
137R:R:H178 5.04469
138R:R:F182 3.9175408
139R:R:F185 6.256568
140R:R:N192 6.1125458
141R:R:F222 6.955656
142R:R:Q223 3.8625457
143R:R:Y224 3.6575408
144R:R:I226 6.8725456
145R:R:N229 7.58408
146R:R:W232 10.6554229
147R:R:E236 5.475409
148R:R:Y239 5.184508
149R:R:L240 3.5975409
150R:R:H241 5.9525408
151R:R:W263 6.51754229
152R:R:P266 4.4925359
153R:R:W273 5.462558
154R:R:W286 8.11559
155R:R:W295 5.0725406
156R:R:I298 6.34457
157R:R:V302 3.432506
158R:R:K323 4.06439
159R:R:H336 2.72754376
160R:R:L350 8.0825468
161R:R:F351 4.53669
162R:R:H354 5.77408
163R:R:Y355 9.738508
164R:R:F358 5.8545147
165R:R:S361 3.2725145
166R:R:Q369 4.50254147
167R:R:L374 4.0525407
168R:R:Q380 4.5325469
169R:R:V384 2.985469
170R:R:Y388 7.8525468
171R:R:N392 7.8425409
172R:R:E398 7.5475408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:L55 99.60475.43YesNo1796
2A:A:K34 B:B:L55 1005.64NoNo046
3A:A:K34 A:A:Q35 99.9169.49NoNo043
4B:B:D76 B:B:K78 96.005212.44YesYes098
5A:A:Q35 R:R:R252 99.83147.01NoNo034
6A:A:H387 A:A:I383 10.39972.65NoNo088
7A:A:H387 R:R:L243 10.55819.28NoNo088
8R:R:L243 R:R:Y239 10.87423.52NoYes088
9R:R:T173 R:R:Y239 99.28924.99NoYes078
10R:R:R252 R:R:T173 99.332210.35NoNo047
11A:A:W234 B:B:Y145 26.77023.86YesYes298
12B:B:G162 B:B:Y145 37.1182.9NoYes098
13B:B:G162 B:B:S161 37.26211.86NoYes099
14B:B:L146 B:B:S161 34.53554.5YesYes979
15B:B:C121 B:B:L146 42.38123.17NoYes087
16B:B:C121 B:B:C149 42.37141.82NoNo088
17B:B:C149 B:B:T102 43.12526.76NoNo088
18B:B:G115 B:B:T102 43.22391.82NoNo098
19B:B:C114 B:B:G115 43.56931.96YesNo089
20B:B:C114 B:B:L79 22.75483.17YesYes087
21B:B:L79 B:B:V71 56.28742.98YesNo078
22B:B:C114 B:B:Y124 21.34372.69YesYes186
23A:A:R231 A:A:W234 21.85735NoYes099
24A:A:L272 A:A:R231 21.54793.64YesNo089
25A:A:F246 A:A:L272 20.92623.65YesYes098
26A:A:F246 A:A:L289 20.45612.44YesNo099
27A:A:F273 A:A:F345 20.14211.79YesNo098
28A:A:F345 A:A:L289 20.29918.53NoNo089
29A:A:F273 A:A:W277 11.9453.01YesYes796
30A:A:Y391 R:R:Y239 72.09033.97YesYes048
31A:A:Y391 R:R:H178 60.8147.62YesYes649
32R:R:H178 R:R:Y388 25.47355.44YesYes698
33B:B:V71 B:B:Y105 60.88126.31NoYes086
34B:B:H62 B:B:Y105 60.72124.36NoYes066
35B:B:H62 B:B:R150 60.681311.28NoYes066
36B:B:C148 B:B:R150 29.89062.79NoYes1966
37B:B:C148 B:B:S160 29.84063.44NoYes1966
38B:B:S160 B:B:V187 59.63096.46YesNo069
39B:B:S201 B:B:V187 59.52473.23YesNo099
40B:B:H183 B:B:S201 27.64285.58YesYes1299
41B:B:H183 B:B:K209 27.05022.62YesYes1296
42B:B:K209 B:B:T221 57.249710.51YesNo067
43B:B:T221 G:G:E22 56.94259.88NoYes079
44B:B:L190 B:B:R150 30.07652.43YesYes1956
45B:B:L190 B:B:S160 30.00423YesYes1956
46B:B:S201 B:B:W211 31.11547.41YesYes1298
47B:B:K209 B:B:W211 27.04916.96YesYes1268
48G:G:E22 G:G:R27 47.08663.49YesYes498
49B:B:D258 G:G:R27 45.801816.68YesYes478
50B:B:D258 B:B:F222 44.69025.97YesYes478
51B:B:F222 B:B:L255 36.88612.44YesNo486
52B:B:L255 B:B:R256 36.76833.64NoNo069
53B:B:N239 B:B:R256 36.45026.03NoNo029
54B:B:N237 B:B:N239 36.13210.9YesNo052
55B:B:F235 B:B:N237 33.215713.29YesYes1065
56B:B:F235 B:B:F278 17.76365.36YesYes1067
57B:B:F278 B:B:L285 15.48857.31YesYes1076
58B:B:L285 B:B:Y264 14.18732.34YesYes065
59B:B:F235 G:G:C41 13.85464.19YesNo067
60B:B:L300 G:G:C41 13.52743.17NoNo067
61B:B:L300 B:B:R283 12.54520.65NoYes069
62B:B:I93 B:B:P94 97.25566.77YesNo075
63R:R:F182 R:R:H178 27.54494.53YesYes089
64R:R:F182 R:R:V384 25.20862.62YesYes089
65R:R:F185 R:R:V384 40.24683.93YesYes689
66R:R:F185 R:R:N229 39.212814.5YesYes088
67R:R:N229 R:R:R188 38.60437.23YesNo088
68R:R:R188 R:R:Y150 38.48317.2NoYes087
69R:R:V384 R:R:Y388 25.43072.52YesYes698
70R:R:Q380 R:R:V384 10.17622.87YesYes699
71R:R:F351 R:R:L350 15.3052.44YesYes698
72R:R:F351 R:R:N309 28.75682.42YesNo099
73R:R:L234 R:R:N309 28.33318.24NoNo089
74R:R:L234 R:R:S305 35.03213NoNo087
75R:R:S305 R:R:V302 34.50483.23NoYes076
76L:L:H1 R:R:V302 24.52582.77YesYes006
77R:R:I177 R:R:Y239 15.51647.25NoYes098
78R:R:E236 R:R:I177 15.45412.73YesNo099
79L:L:H1 R:R:I298 10.88092.65YesYes507
80R:R:Y146 R:R:Y150 34.9913.97YesYes577
81L:L:F6 R:R:Y146 33.12095.16YesYes507
82L:L:F6 R:R:L139 33.36642.44YesYes504
83L:L:L13 R:R:L139 31.9931.38YesYes004
84L:L:L13 R:R:N132 30.58791.37YesNo003
85R:R:D129 R:R:N132 30.353216.16NoNo023
86R:R:D129 R:R:V127 29.88362.92NoNo022
87R:R:N126 R:R:V127 29.64855.91NoNo032
88R:R:L121 R:R:N126 29.41341.37YesNo053
89R:R:L121 R:R:T115 27.03152.95YesYes854
90R:R:P117 R:R:T115 25.88421.75NoYes844
91R:R:F116 R:R:P117 16.36472.89YesNo844
92R:R:F116 R:R:R118 13.336812.83YesNo046
93R:R:N120 R:R:R118 12.84963.62NoNo056
94R:R:L103 R:R:N120 12.60571.37YesNo075
95R:R:L93 R:R:P90 10.886811.49NoNo058
96R:R:W273 R:R:W286 11.5922.81YesYes589
97R:R:M227 R:R:V302 10.4413.04NoYes066
98B:B:K78 B:B:P94 97.22945.02YesNo085
99B:B:I93 B:B:L79 75.53454.28YesYes077
100B:B:I93 B:B:Y124 21.35543.63YesYes176
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H1 R:R:Q223 2.47 5 Yes Yes 0 7 0 1
L:L:H1 R:R:I226 11.93 5 Yes Yes 0 6 0 1
L:L:H1 R:R:I298 2.65 5 Yes Yes 0 7 0 1
L:L:H1 R:R:V302 2.77 5 Yes Yes 0 6 0 1
L:L:S2 R:R:E373 12.94 0 No No 0 7 0 1
L:L:S2 R:R:L374 3 0 No Yes 0 7 0 1
L:L:D3 R:R:N192 6.73 5 Yes Yes 0 8 0 1
L:L:D3 R:R:F222 8.36 5 Yes Yes 0 6 0 1
L:L:D3 R:R:I226 5.6 5 Yes Yes 0 6 0 1
L:L:G4 R:R:W295 2.81 0 No Yes 0 6 0 1
L:L:T5 R:R:W295 2.43 0 No Yes 0 6 0 1
L:L:F6 R:R:L139 2.44 5 Yes Yes 0 4 0 1
L:L:F6 R:R:L142 3.65 5 Yes No 0 6 0 1
L:L:F6 R:R:Y146 5.16 5 Yes Yes 0 7 0 1
L:L:F6 R:R:L370 6.09 5 Yes No 0 6 0 1
L:L:S8 R:R:N289 8.94 0 No No 0 6 0 1
L:L:L10 R:R:L139 6.92 5 No Yes 0 4 0 1
L:L:L10 R:R:F200 7.31 5 No No 0 4 0 1
L:L:S11 R:R:D287 2.94 0 No No 0 6 0 1
L:L:L13 R:R:R135 9.72 0 Yes No 0 3 0 1
L:L:L13 R:R:H136 6.43 0 Yes No 0 1 0 1
L:L:E15 R:R:R30 3.49 0 No No 0 6 0 1
L:L:E15 R:R:L31 5.3 0 No Yes 0 4 0 1
L:L:R18 R:R:L31 3.64 0 No Yes 0 4 0 1
L:L:L19 R:R:L31 4.15 0 No Yes 0 4 0 1
L:L:L26 R:R:I73 2.85 0 No Yes 0 5 0 1
L:L:V27 R:R:I73 7.68 8 Yes Yes 0 5 0 1
L:L:V27 R:R:L121 2.98 8 Yes Yes 0 5 0 1
L:L:V27 R:R:A122 5.09 8 Yes No 0 5 0 1
R:R:L31 R:R:L35 4.15 0 Yes No 4 2 1 1
R:R:D71 R:R:I73 5.6 0 No Yes 9 5 2 1
R:R:E114 R:R:I73 5.47 8 No Yes 2 5 2 1
R:R:I73 R:R:T115 3.04 8 Yes Yes 5 4 1 2
R:R:E114 R:R:T115 8.47 8 No Yes 2 4 2 2
R:R:L121 R:R:T115 2.95 8 Yes Yes 5 4 1 2
R:R:A122 R:R:L121 3.15 8 No Yes 5 5 1 1
R:R:D129 R:R:N132 16.16 0 No No 2 3 2 1
R:R:R135 R:R:S131 9.22 0 No No 3 2 1 2
R:R:L139 R:R:Y138 2.34 5 Yes No 4 4 1 2
R:R:L142 R:R:L374 5.54 0 No Yes 6 7 1 1
R:R:K143 R:R:Y146 2.39 0 No Yes 5 7 2 1
R:R:T147 R:R:Y146 8.74 0 No Yes 6 7 2 1
R:R:Y146 R:R:Y150 3.97 5 Yes Yes 7 7 1 2
R:R:N192 R:R:Y146 3.49 5 Yes Yes 8 7 1 1
R:R:L374 R:R:Y146 3.52 0 Yes Yes 7 7 1 1
R:R:S378 R:R:Y146 2.54 5 No Yes 9 7 2 1
R:R:N192 R:R:Y150 6.98 5 Yes Yes 8 7 1 2
R:R:S378 R:R:Y150 7.63 5 No Yes 9 7 2 2
R:R:F222 R:R:S191 5.28 5 Yes No 6 5 1 2
R:R:F222 R:R:N192 7.25 5 Yes Yes 6 8 1 1
R:R:F222 R:R:K195 7.44 5 Yes No 6 7 1 2
R:R:F200 R:R:L199 8.53 0 No No 4 6 1 2
R:R:F222 R:R:Q223 5.86 5 Yes Yes 6 7 1 1
R:R:F222 R:R:I226 7.54 5 Yes Yes 6 6 1 1
R:R:Q223 R:R:W273 4.38 5 Yes Yes 7 8 1 2
R:R:I298 R:R:Q223 2.74 5 Yes Yes 7 7 1 1
R:R:I226 R:R:Y230 2.42 5 Yes No 6 8 1 2
R:R:M227 R:R:V302 3.04 0 No Yes 6 6 2 1
R:R:V302 R:R:Y230 5.05 0 Yes No 6 8 1 2
R:R:Y230 R:R:Y355 19.86 0 No Yes 8 8 2 2
R:R:I298 R:R:W273 10.57 5 Yes Yes 7 8 1 2
R:R:N289 R:R:W295 5.65 0 No Yes 6 6 1 1
R:R:I298 R:R:W295 9.4 5 Yes Yes 7 6 1 1
R:R:S305 R:R:V302 3.23 0 No Yes 7 6 2 1
R:R:I306 R:R:V302 3.07 0 No Yes 7 6 2 1
R:R:I306 R:R:Y355 3.63 0 No Yes 7 8 2 2
R:R:E373 R:R:Y355 11.22 0 No Yes 7 8 1 2
R:R:E373 R:R:Q369 5.1 0 No Yes 7 7 1 2
R:R:L370 R:R:L374 4.15 0 No Yes 6 7 1 1
R:R:C285 R:R:D287 1.56 34 No No 9 6 2 1
R:R:L35 R:R:V34 1.49 0 No No 2 4 1 2
L:L:L13 R:R:L139 1.38 0 Yes Yes 0 4 0 1
L:L:L22 R:R:L35 1.38 0 No No 0 2 0 1
L:L:L13 R:R:N132 1.37 0 Yes No 0 3 0 1
R:R:L121 R:R:N126 1.37 8 Yes No 5 3 1 2
L:L:R12 R:R:R135 1.07 0 No No 0 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
86.36Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
75.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
69.23Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
67.86Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
66.67Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
66.67Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
65.38Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
64.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
64.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
64.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
62.96Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
62.96Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
62.50Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
61.54Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
61.54Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
61.54Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
60.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
60.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
59.26Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
59.26Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
59.26Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
57.14Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
57.14Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
55.56Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
55.56Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
55.56Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
55.56Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
54.55Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
53.85Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
53.85Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
53.85Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
53.85Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
53.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
53.12Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
52.17Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
52.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
51.85Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
51.85Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
51.72Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
51.61Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
50.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
50.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
50.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
50.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
48.39Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
48.28Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
48.28Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
48.28Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
48.28Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
48.15Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
48.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
46.88Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
46.88Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
46.88Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
46.43Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
46.43Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
46.15Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
45.45Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
45.45Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
45.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
44.83Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
44.44Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
43.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
43.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
42.86Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
42.42Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
41.94Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
41.94Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
41.38Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
41.18Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
41.18Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.62Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
40.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
40.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
40.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
40.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
38.71Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
38.71Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
37.93Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.93Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
37.93Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.93Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
37.93Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.93Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
37.50Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
37.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
37.50Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
37.50Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
37.50Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
37.50Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
37.50Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
37.14Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
37.04Single4XT1Fractalkine4XT1-US28-Fractalkine
36.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
36.36Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
36.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
36.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
36.00Consensuslpa_offOrthosteric Ligandlpa1_off
35.48Single4XT3Fractalkine4XT3-US28-Fractalkine
35.48Single6FJ3PTH6FJ3-PTH1-PTH
35.48Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
35.48Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
35.48Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
35.29Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
35.29Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
35.29Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
35.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.62Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
34.62Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
34.48Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
34.48Consensusangiotensin_onOrthosteric Ligandat1_on
34.48Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.48Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
34.38Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
34.38Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
34.38Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
33.33Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
33.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
33.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
33.33Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
32.35Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
32.26Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
32.26Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
32.26Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
32.14Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
32.14Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
32.14Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
32.14Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.14Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.00Single5XR8AM8415XR8-CB1-AM841
32.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
32.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
32.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
32.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
32.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
32.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.82Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.43Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
31.25Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.03Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
31.03Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
31.03Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
31.03Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
31.03Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
31.03Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
30.77Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
30.77Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
30.77Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
30.77Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
30.77Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
30.77Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
30.77Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
30.77Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
30.77Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
30.77Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
30.77Consensuslpl_offOrthosteric Ligands1p_off lpa_off
30.43Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
30.43Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
30.43Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.30Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
30.30Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
30.30Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
30.30Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
29.63Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
29.63Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
29.63Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
29.63Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
29.63Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
29.63Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.63Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
29.27Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
29.17Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
29.17Single7V3ZCP559407V3Z-CB1-CP55940
29.17Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
29.17Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
29.17Single9B9ZA1AKO9B9Z-CB1-A1AKO
29.17Single9CHXS-Carazolol9CHX-β2-S-Carazolol
29.17Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
29.17Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
29.17Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
29.17Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
29.03Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
29.03Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.03Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
29.03Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
29.03Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
29.03Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.03Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
29.03Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
29.03Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.03Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.03Consensusvasop-oxy_onOrthosteric Ligandv2_on
29.03Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
28.57Single3NY9ICI118-5513NY9-β2-ICI118-551
28.57Single4UG2CGS216804UG2-A2A-CGS21680
28.57Single5GLHEndothelin-15GLH-ETB-Endothelin-1
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
28.57Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
28.57Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
28.57Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
28.57Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
28.57Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
28.57Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
28.57Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
28.12Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single8ZRTET-18ZRT-ETB-ET-1
28.12Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
28.00Single5C1MBU725C1M-μ-BU72
28.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
28.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
28.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
28.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
28.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
28.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
28.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
28.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
28.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
28.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
28.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
28.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
28.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
28.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
28.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
28.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
28.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
28.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
28.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
28.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
28.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
28.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Consensustrace-amine_onOrthosteric Ligandta1_on
27.59Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
27.59Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
27.59Single8WDTphotoNECA8WDT-A2A-photoNECA
27.59Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.59Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
27.59Consensuslpl_onOrthosteric Ligands1p_on lpa_on
27.59Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
27.59Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
27.27Single6LI0C176LI0-GPR52-C17
27.27Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
27.27Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
27.27Single9B9Y7DY9B9Y-CB1-7DY
27.27Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
27.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
26.92Single2YDVNECA2YDV-A2A-NECA
26.92Single3P0GBI1671073P0G-β2-BI167107
26.92Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.92Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.92Single4UHRCGS216804UHR-A2A-CGS21680
26.92Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.92Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
26.92Single5G53NECA5G53-A2A-NECA-Gs
26.92Single5XRAAM115425XRA-CB1-AM11542
26.92Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
26.92Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
26.92Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
26.92Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
26.92Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.92Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
26.92Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single8E0GBU728E0G-μ-BU72
26.92Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
26.92Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
26.92Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
26.92Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.92Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
26.92Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
26.92Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
26.92Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.92Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.92Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
26.92Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
26.92Consensuslpa_onOrthosteric Ligandlpa1_on
26.92Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
26.92Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
26.67Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
26.67Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
26.67Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
26.67Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
26.67Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
26.67Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.47Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
26.47Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
26.09Single5U09Taranabant5U09-CB1-Taranabant
26.09Single6AKXA4R6AKX-CCR5-A4R
26.09Single6AKYMaraviroc6AKY-CCR5-Maraviroc
26.09Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
26.09Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
26.09Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
26.09Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
26.09Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
26.09Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
26.09Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
26.09Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
26.09Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
26.09Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
26.09Single9BA0A1AKN9BA0-CB1-A1AKN
26.09Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
25.93Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
25.93Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
25.93Single6MXTSalmeterol6MXT-β2-Salmeterol
25.93Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
25.93Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
25.93Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
25.93Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
25.93Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
25.93Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.93Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.93Single8JJ8Formoterol8JJ8-β2-Formoterol
25.93Single8JJLOlodaterol8JJL-β2-Olodaterol
25.93Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
25.93Single8XYIVUF106618XYI-CXCR3-VUF10661
25.93Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.93Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.93Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
25.93Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
25.93Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
25.93Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.93Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
25.93Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
25.93Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.93Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.81Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.81Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.81Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
25.81Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
25.81Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.81Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.81Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
25.71Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
25.71Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.71Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.71Consensusbradykinin_onOrthosteric Ligandbk2_on
25.71Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
25.71Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.71Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
25.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
25.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
25.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
25.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
25.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
25.00Single6PS4ICI118-5516PS4-β2-ICI118-551
25.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
25.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
25.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
25.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
25.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
25.00Single7UL3Famotidine7UL3-H2-Famotidine
25.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
25.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
25.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
25.00Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
25.00Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
25.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
25.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
25.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
25.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
25.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
25.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
25.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
25.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
25.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
25.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
25.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
25.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
25.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
25.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
25.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
25.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
25.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
25.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
25.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
25.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
25.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
25.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.00Consensuschemerin_onOrthosteric Ligandcml1_on
25.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
24.32Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
24.24Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
24.24Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
24.24Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
24.24Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
24.24Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
24.24Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
24.24Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
24.24Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
24.24Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.24Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
24.24Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
24.24Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.14Single5EE7MK08935EE7-Glucagon-MK0893
24.14Single5ZTYAM102575ZTY-CB2-AM10257
24.14Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
24.14Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
24.14Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
24.14Single7SK9CCX6627SK9-ACKR3-CCX662
24.14Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
24.14Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
24.14Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
24.14Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
24.14Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
24.14Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
24.14Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
24.00Single2Y04Salbutamol2Y04-β1-Salbutamol
24.00Single3NY8ICI118-5513NY8-β2-ICI118-551
24.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
24.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
24.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
24.00Single4QKX35V4QKX-β2-35V
24.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
24.00Single5UENDU1725UEN-A1-DU172
24.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
24.00Single6H7MSalbutamol6H7M-β1-Salbutamol
24.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
24.00Single6PS1Timolol6PS1-β2-Timolol
24.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
24.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
24.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
24.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
24.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
24.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
24.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
24.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
24.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
24.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
24.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
24.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
24.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
24.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
24.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
24.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
24.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
24.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
24.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
24.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
24.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
24.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
24.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
24.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
24.00Single8JXRLSD8JXR-D1-LSD
24.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
24.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
24.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
24.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
24.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
24.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
24.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
24.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
24.00Consensusa3_onOrthosteric Liganda3a_on
24.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
24.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
24.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
24.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
24.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
24.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
24.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
24.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
24.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
24.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
24.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
23.68Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
23.53Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.53Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
23.53Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
23.53Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
23.53Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.53Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
23.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
23.33Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
23.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
23.33Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.33Single7QA8Peptide7QA8-STE2-Peptide
23.33Single7QA8Peptide7QA8-STE2-Peptide
23.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
23.33Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
23.33Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
23.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
23.33Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
23.33Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
23.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
23.08Single2RH1S-Carazolol2RH1-β2-S-Carazolol
23.08Single2Y03Isoprenaline2Y03-β1-Isoprenaline
23.08Single2YCWS-Carazolol2YCW-β1-S-Carazolol
23.08Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
23.08Single5D6LS-Carazolol5D6L-β2-S-Carazolol
23.08Single5JQHS-Carazolol5JQH-β2-S-Carazolol
23.08Single5TVNLSD5TVN-5-HT2B-LSD
23.08Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
23.08Single6E67BI1671076E67-β2-BI167107-Gs (fused)
23.08Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
23.08Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.08Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
23.08Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
23.08Single7C61Ergotamine7C61-5-HT1B-Ergotamine
23.08Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
23.08Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.08Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
23.08Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
23.08Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
23.08Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.08Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
23.08Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8JXSPF-61428JXS-D1-PF-6142
23.08Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.08Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
23.08Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
23.08Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
23.08Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
23.08Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
23.08Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
23.08Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.08Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.08Consensusa3_on_gpOrthosteric Liganda3a_on_gp
23.08Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.08Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.08Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
23.08Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
23.08Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
23.08Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
23.08Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
23.08Consensusamine_offonOrthosteric Ligandamine_off amine_on
23.08Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
23.08Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
23.08Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
23.08Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
23.08Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.08Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.08Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
22.86Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
22.86Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
22.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.86Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.86Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
22.86Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
22.86Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.86Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.73Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
22.73Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
22.73Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
22.73Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
22.58Single3QAKUK-4320973QAK-A2A-UK-432097
22.58Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
22.58Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.58Single7XNACYN1548067XNA-SST2-CYN154806
22.58Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
22.58Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
22.58Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
22.58Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.58Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.58Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
22.58Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
22.58Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
22.58Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.58Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.58Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.58Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.22Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
22.22Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.22Single5D5AS-Carazolol5D5A-β2-S-Carazolol
22.22Single5D5BS-Carazolol5D5B-β2-S-Carazolol
22.22Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
22.22Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
22.22Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
22.22Single6H7JIsoprenaline6H7J-β1-Isoprenaline
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single6J21Aprepitant6J21-NK1-Aprepitant
22.22Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
22.22Single6WGTLSD6WGT-5-HT2A-LSD
22.22Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
22.22Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
22.22Single7F1TMIP-1a7F1T-CCR5-MIP-1a
22.22Single7FEECP559407FEE-CB1-CP55940-ZCZ011
22.22Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
22.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.22Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
22.22Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
22.22Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
22.22Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
22.22Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
22.22Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
22.22Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
22.22Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
22.22Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
22.22Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
22.22Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.22Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
22.22Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
22.22Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
22.22Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
22.22Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
22.22Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
22.22Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.22Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
22.22Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
22.22Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
22.22Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
22.22Consensusa2_onOrthosteric Liganda2b_on
22.22Consensusa2_on_gpOrthosteric Liganda2b_on_gp
22.22Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
22.22Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
22.22Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
22.22Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
22.22Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
22.22Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
22.22Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.22Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
22.22Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.22Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.95Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.95Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.88Single3OE0CVX153OE0-CXCR4-CVX15
21.88Single5WF5UK-4320975WF5-A2A-UK-432097
21.88Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
21.88Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.88Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
21.88Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.88Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
21.88Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
21.88Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
21.88Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.88Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.88Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
21.88Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
21.74Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
21.74Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
21.74Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.74Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
21.74Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
21.74Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
21.74Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
21.74Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
21.74Single8K5BNiacin8K5B-HCA2-Niacin
21.74Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.74Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
21.74Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
21.74Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
21.74Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
21.74Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.74Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.62Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.62Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.62Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
21.62Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
21.43Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.43Single3D4STimolol3D4S-β2-Timolol
21.43Single4AMIBucindolol4AMI-β1-Bucindolol
21.43Single4LDEBI1671074LDE-β2-BI167107
21.43Single4N4WSANT-14N4W-SMO-SANT-1
21.43Single4RWADIPP-NH24RWA-δ-DIPP-NH2
21.43Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
21.43Single6CM4Risperidone6CM4-D2-Risperidone
21.43Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
21.43Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
21.43Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
21.43Single6KQICP559406KQI-CB1-CP55940-Org27569
21.43Single6OS2TRV0266OS2-AT1-TRV026
21.43Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
21.43Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.43Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
21.43Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.43Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.43Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
21.43Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
21.43Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.43Single7YITNalfurafine7YIT-κ-Nalfurafine
21.43Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
21.43Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
21.43Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
21.43Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
21.43Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
21.43Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
21.43Single8JWY2-1188JWY-A2A-2-118
21.43Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.43Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
21.43Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
21.43Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.43Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.43Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.43Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.43Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
21.43Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
21.43Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.43Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
21.43Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
21.43Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
21.43Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
21.43Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.21Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
21.21Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
21.21Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
21.21Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.21Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
21.21Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.21Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.21Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.21Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.05Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.05Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
21.05Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
20.83Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
20.83Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.83Single6ME2Ramelteon6ME2-MT1-Ramelteon
20.83Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
20.83Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
20.83Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
20.83Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.83Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
20.83Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
20.83Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
20.83Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
20.83Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.83Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.83Single8GNGIstradefylline8GNG-A2A-Istradefylline
20.83Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
20.83Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
20.83Single8IWESpermidine8IWE-TA9-Spermidine
20.83Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.83Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
20.83Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
20.83Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.83Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.83Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
20.83Consensusalpha2_offOrthosteric Ligandalpha2c_off
20.83Consensusangiotensin_offOrthosteric Ligandat1_off
20.83Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.83Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.83Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.83Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
20.83Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
20.83Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.83Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.69Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.69Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.69Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.69Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
20.69Single6H7LDobutamine6H7L-β1-Dobutamine
20.69Single6IBLArformoterol6IBL-β1-Arformoterol
20.69Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.69Single7EZCUKA7EZC-A2A-UKA
20.69Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.69Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.69Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
20.69Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
20.69Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
20.69Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
20.69Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.69Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.69Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.69Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.69Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.69Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.69Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.69Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.69Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.69Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
20.69Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
20.69Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
20.69Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
20.69Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
20.69Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
20.59Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.59Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.59Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
20.59Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.59Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.59Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.59Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
20.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
20.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.00Single5WF6UK-4320975WF6-A2A-UK-432097
20.00Single6A94Zotepine6A94-5-HT2A-Zotepine
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Single6PT3DPI-2876PT3-δ-DPI-287
20.00Single6VI4JDTic6VI4-κ-JDTic
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
20.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
20.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.00Single7T32ZM-2413857T32-A2A-ZM-241385
20.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
20.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7XN9L-054,5227XN9-SST2-L-054,522
20.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
20.00Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
20.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
20.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
20.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
20.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
20.00Single8K5CAcipimox8K5C-HCA2-Acipimox
20.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
20.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
20.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
20.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
20.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
20.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
20.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
20.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
20.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
20.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
20.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
20.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
20.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.00Consensushca_onOrthosteric Ligandhca2_on
20.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
19.44Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
19.44Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
19.44Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.35Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
19.35Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
19.35Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
19.35Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
19.35Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
19.35Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
19.35Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
19.35Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.35Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
19.35Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.35Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
19.35Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
19.35Consensussomatostatin_offOrthosteric Ligandsst2_off
19.35Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.23Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
19.23Single2Y01Dobutamine2Y01-β1-Dobutamine
19.23Single2Y02Carmoterol2Y02-β1-Carmoterol
19.23Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
19.23Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
19.23Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
19.23Single4EJ4Naltrindole4EJ4-δ-Naltrindole
19.23Single4YAYZD-71554YAY-AT1-ZD-7155
19.23Single5TGZAM65385TGZ-CB1-AM6538
19.23Single6D27CAY104716D27-DP2-CAY10471
19.23Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
19.23Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
19.23Single7BU7BI1671077BU7-β1-BI167107
19.23Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.23Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
19.23Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
19.23Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
19.23Single7UL4Alvimopan7UL4-μ-Alvimopan
19.23Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
19.23Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
19.23Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
19.23Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
19.23Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.23Single8CU6LJ-45178CU6-A2A-LJ-4517
19.23Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
19.23Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
19.23Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
19.23Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
19.23Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.23Single8JJOAlprenolol8JJO-β2-Alprenolol
19.23Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
19.23Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
19.23Single8K5DGSK2560738K5D-HCA2-GSK256073
19.23Single8RLNLUF58348RLN-A2A-LUF5834
19.23Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
19.23Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
19.23Single8T1WCVN4248T1W-GPR6-CVN424
19.23Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
19.23Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.23Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
19.23Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
19.23Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
19.23Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
19.23Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
19.23Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
19.23Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.23Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
19.23Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
19.23Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.23Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.23Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.23Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.23Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
19.23Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
19.23Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
19.23Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
19.15Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.05Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.92Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
18.92Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.92Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.92Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
18.75Single6HLOAprepitant6HLO-NK1-Aprepitant
18.75Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.75Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.75Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
18.75Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
18.75Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.75Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
18.75Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
18.75Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.75Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
18.52Single2Y00Dobutamine2Y00-β1-Dobutamine
18.52Single4JKVTaladegib4JKV-SMO-Taladegib
18.52Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
18.52Single5N2RPSB-365N2R-A2A-PSB-36-Na
18.52Single5N2SPSB365N2S-A1-PSB36
18.52Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.52Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
18.52Single5WIUNemonapride5WIU-D4-Nemonapride
18.52Single5WIVNemonapride5WIV-D4-Nemonapride-Na
18.52Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.52Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.52Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
18.52Single6LUQHaloperidol6LUQ-D2-Haloperidol
18.52Single6PS6Timolol6PS6-β2-Timolol
18.52Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.52Single7C4SS1P7C4S-S1P3-S1P
18.52Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
18.52Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.52Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.52Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.52Single7WC6LSD7WC6-5-HT2A-LSD
18.52Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
18.52Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.52Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.52Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
18.52Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.52Single8QOTNanobody-E8QOT-μ-Nanobody-E
18.52Single8S4DCMF-0198S4D-Apelin-CMF-019
18.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
18.52Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
18.52Single8ZMFA1L108ZMF-5-HT2C-A1L10
18.52Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.52Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
18.52Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.52Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
18.52Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
18.52Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
18.52Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
18.52Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.52Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
18.52Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
18.52Consensusdp_offOrthosteric Liganddp2_off
18.52Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.52Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.52Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.52Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
18.52Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.52Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.52Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.52Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
18.42Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
18.42Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
18.42Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.42Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.42Consensusbombesin_onOrthosteric Ligandbb2_on
18.42Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
18.42Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.18Single6PT2KGCHM076PT2-δ-KGCHM07
18.18Single6W25SHU91196W25-MC4-SHU9119-Ca
18.18Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
18.18Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
18.18Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.18Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
18.18Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
18.18Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
18.18Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.18Single9CHUNoradrenaline9CHU-β2-Noradrenaline
18.18Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
18.18Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.18Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.95Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
17.86Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.86Single4DJHJDTic4DJH-κ-JDTic
17.86Single4U15Tiotropium4U15-M3-Tiotropium
17.86Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.86Single5V56TC1145V56-SMO-TC114
17.86Single5V57TC1145V57-SMO-TC114
17.86Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
17.86Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.86Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.86Single6OL9Tiotropium6OL9-M5-Tiotropium
17.86Single6OS1TRV0266OS1-AT1-TRV026
17.86Single7B6WCyclazosin7B6W-α1b-Cyclazosin
17.86Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
17.86Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
17.86Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
17.86Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.86Single7PX4PSB-21137PX4-A2A-PSB-2113
17.86Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
17.86Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
17.86Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
17.86Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
17.86Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
17.86Single8EA0Iperoxo8EA0-M3-Iperoxo
17.86Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.86Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.86Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
17.86Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
17.86Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.86Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
17.86Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.86Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
17.86Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
17.86Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
17.86Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
17.86Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
17.86Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.86Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
17.86Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.86Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.86Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
17.86Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.86Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.86Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.86Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.86Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
17.86Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.86Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.86Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.86Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
17.65Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.65Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.65Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.65Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.65Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.65Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.65Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
17.39Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.39Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
17.39Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.39Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
17.39Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
17.39Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
17.39Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
17.39Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.39Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
17.39Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
17.39Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.39Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
17.39Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
17.39Consensus5ht2_onOrthosteric Ligand5ht2b_on
17.39Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.39Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.39Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.24Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.24Single4XEENeurotensin4XEE-NTS1-Neurotensin
17.24Single4XESNeurotensin4XES-NTS1-Neurotensin
17.24Single5CXVTiotropium5CXV-M1-Tiotropium
17.24Single6A93Risperidone6A93-5-HT2A-Risperidone
17.24Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.24Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
17.24Single6IIURamatroban6IIU-TP-Ramatroban
17.24Single6YVRNTS8-136YVR-NTS1-NTS8-13
17.24Single7DFPSpiperone7DFP-D2-Spiperone
17.24Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.24Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.24Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
17.24Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
17.24Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
17.24Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
17.24Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
17.24Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
17.24Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.24Single8JWZAB9288JWZ-A2A-AB928-Na
17.24Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.24Consensusalpha1_offOrthosteric Ligandalpha1a_off
17.24Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
17.24Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.24Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
17.24Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.24Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
17.24Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
17.24Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
17.24Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.24Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.24Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.24Consensusorexin_onOrthosteric Ligandox2_on
17.24Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.14Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
17.14Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.14Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.14Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
17.14Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
17.14Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Single3OE9IT1t3OE9-CXCR4-IT1t
16.67Single3PBLEticlopride3PBL-D3-Eticlopride
16.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single5X93K-87945X93-ETB-K-8794
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
16.67Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
16.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7SRQLSD7SRQ-5-HT2B-LSD
16.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
16.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
16.67Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
16.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
16.67Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
16.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.67Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
16.67Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
16.67Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XVJMacitentan8XVJ-ETA-Macitentan
16.67Single8XVUCXCL28XVU-CXCR2-CXCL2
16.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
16.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.67Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
16.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
16.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
16.67Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
16.67Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
16.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
16.67Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.67Consensusendothelin_offOrthosteric Ligandetb_off
16.67Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
16.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
16.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
16.67Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
16.67Consensusprostanoid_offOrthosteric Ligandep_off dp_off
16.13Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
16.13Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.13Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.13Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.13Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
16.13Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
16.13Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
16.13Single8IEIA1LYA8IEI-GPR156-A1LYA
16.13Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.13Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8X5YAstemizole8X5Y-H1-Astemizole
16.13Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
16.13Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.13Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
16.13Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.13Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
16.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
16.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
16.00Single3PWHZM-2413853PWH-A2A-ZM-241385
16.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
16.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
16.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
16.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
16.00Single6B73MP11046B73-κ-MP1104
16.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
16.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
16.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
16.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
16.00Single6TODEMPA6TOD-OX1-EMPA-Na
16.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
16.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
16.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
16.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
16.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
16.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
16.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
16.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
16.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
16.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
16.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
16.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
16.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
16.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
16.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
16.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
16.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
16.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
16.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
16.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
16.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
16.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
16.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
16.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
16.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
16.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
16.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
16.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
16.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
16.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.79Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.62Single7F8XNN90567F8X-CCKA-NN9056
15.62Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
15.62Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
15.62Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
15.62Single8IEBA1LYA8IEB-GPR156-A1LYA
15.62Single8IEIA1LYA8IEI-GPR156-A1LYA
15.62Single8IEPA1LYA8IEP-GPR156-A1LYA
15.62Single8IEPA1LYA8IEP-GPR156-A1LYA
15.62Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
15.62Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.62Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
15.62Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
15.62Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.62Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.38Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.38Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
15.38Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
15.38Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.38Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
15.38Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.38Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.38Single5JTBZM-2413855JTB-A2A-ZM-241385
15.38Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.38Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
15.38Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
15.38Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
15.38Single6AQFZM-2413856AQF-A2A-ZM-241385
15.38Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.38Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
15.38Single6MH8ZM-2413856MH8-A2A-ZM-241385
15.38Single6TPGEMPA6TPG-OX2-EMPA
15.38Single6TPNHTL66416TPN-OX2-HTL6641
15.38Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
15.38Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.38Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.38Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.38Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.38Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
15.38Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
15.38Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
15.38Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
15.38Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.38Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.38Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.38Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.38Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.38Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.38Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
15.38Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
15.38Single8IHKAcifran8IHK-HCA3-Acifran
15.38Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
15.38Single8K2WAMG4878K2W-CXCR3-AMG487
15.38Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
15.38Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
15.38Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
15.38Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
15.38Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
15.38Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
15.38Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.38Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
15.38Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
15.38Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
15.38Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
15.38Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
15.38Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.38Single9BJKNaloxone9BJK-μ-Naloxone-NAM
15.38Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
15.38Consensusa2_offOrthosteric Liganda2a_off
15.38Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
15.38Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.38Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.38Consensusopsins_offOrthosteric Ligandrhodopsin_off
15.38Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.38Consensussensory_offOrthosteric Ligandopsins_off
15.15Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
15.15Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.15Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
15.15Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
15.15Single7SK5CXCL127SK5-ACKR3-CXCL12
15.15Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8IEBA1LYA8IEB-GPR156-A1LYA
15.15Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.15Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.15Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.00Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.81Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
14.81Single3EMLZM-2413853EML-A2A-ZM-241385
14.81Single4DAJTiotropium4DAJ-M3-Tiotropium
14.81Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
14.81Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
14.81Single4MQSIperoxo4MQS-M2-Iperoxo
14.81Single4QIMANTA XV4QIM-SMO-ANTA XV
14.81Single4U14Tiotropium4U14-M3-Tiotropium
14.81Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
14.81Single5DHHSB-6121115DHH-NOP-SB-612111
14.81Single5IU8Q274563475IU8-A2A-Q27456347-Na
14.81Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
14.81Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
14.81Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
14.81Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
14.81Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
14.81Single5UIGCmpd-15UIG-A2A-Cmpd-1
14.81Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
14.81Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
14.81Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
14.81Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
14.81Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.81Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.81Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.81Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.81Single6GPSMK08126GPS-CCR2-MK0812
14.81Single6IIVDaltroban6IIV-TP-Daltroban
14.81Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.81Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
14.81Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
14.81Single6S0LZM-2413856S0L-A2A-ZM-241385
14.81Single6TOTLemborexant6TOT-OX1-Lemborexant
14.81Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.81Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
14.81Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
14.81Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
14.81Single7PYRPSB-21157PYR-A2A-PSB-2115
14.81Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
14.81Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
14.81Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.81Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
14.81Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
14.81Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
14.81Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.81Single7YXAONO-54306087YXA-S1P5-ONO-5430608
14.81Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
14.81Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
14.81Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
14.81Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.81Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
14.81Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
14.81Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.81Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
14.81Single8X63Mepyramine8X63-H1-Mepyramine
14.81Single8X64Desloratadine8X64-H1-Desloratadine
14.81Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
14.81Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
14.81Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
14.81Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
14.81Single9IYAONO-97105319IYA-GPR55-ONO-9710531
14.81Consensusalpha2_onOrthosteric Ligandalpha2b_on
14.81Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
14.81Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.81Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.81Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
14.81Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
14.81Consensusblt_onOrthosteric Ligandblt1_on
14.81Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
14.81Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
14.81Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.81Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
14.81Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
14.81Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
14.81Consensushistamine_offOrthosteric Ligandh1_off
14.81Consensusleukotriene_onOrthosteric Ligandblt_on
14.81Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
14.81Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.81Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
14.71Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
14.71Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
14.71Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
14.71Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
14.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.71Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
14.29Single5IUAQ274563485IUA-A2A-Q27456348-Na
14.29Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.29Single5WQCEMPA5WQC-OX2-EMPA
14.29Single5XPRBosentan5XPR-ETB-Bosentan
14.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.29Single6GPXMK08126GPX-CCR2-MK0812
14.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
14.29Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.29Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
14.29Single6S0QZM-2413856S0Q-A2A-ZM-241385
14.29Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
14.29Single6TP6Filorexant6TP6-OX1-Filorexant
14.29Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.29Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
14.29Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.29Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
14.29Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Single7W41PD1762527W41-BB2-PD176252
14.29Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
14.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
14.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
14.29Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
14.29Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
14.29Single8GNEKW-63568GNE-A2A-KW-6356-Na
14.29Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
14.29Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
14.29Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
14.29Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
14.29Consensusbombesin_offOrthosteric Ligandbb2_off
14.29Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
14.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.29Consensusep_offOrthosteric Ligandep4_off
14.29Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
14.29Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
14.29Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
13.89Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.89Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.79Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
13.79Single4BV0Neurotensin4BV0-NTS1-Neurotensin
13.79Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.79Single6J20Aprepitant6J20-NK1-Aprepitant
13.79Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
13.79Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
13.79Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.79Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
13.79Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
13.79Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
13.79Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
13.79Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.79Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
13.79Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
13.79Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
13.79Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
13.79Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.79Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
13.79Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.79Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.79Single8XVLZibotentan8XVL-ETA-Zibotentan
13.79Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
13.79Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
13.79Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
13.79Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.79Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
13.79Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
13.79Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.79Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusneurotensin_onOrthosteric Ligandnts1_on
13.79Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.79Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
13.79Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.79Consensustachykinin_offOrthosteric Ligandnk1_off
13.64Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.64Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
13.64Single8HS2Fab0468HS2-GPR20-Fab046
13.64Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
13.64Single8PWNTheophylline8PWN-A2A-Theophylline
13.64Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.51Single7SK3CXCL127SK3-ACKR3-CXCL12
13.33Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
13.33Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.33Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.33Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
13.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
13.33Single6ZG4HTL00099366ZG4-M1-HTL0009936
13.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
13.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
13.33Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
13.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
13.33Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
13.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
13.33Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.33Single8XQJJN2418XQJ-Apelin-JN241
13.33Single8XWMCXCL68XWM-CXCR2-CXCL6
13.33Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
13.33Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.33Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
13.33Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
13.33Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
13.04Single3RFMCaffeine3RFM-A2A-Caffeine
13.04Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.04Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.04Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
13.04Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
13.04Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
13.04Consensusp2y_offOrthosteric Ligandp2y1_off
13.04Consensussensory_onOrthosteric Ligandopsins_on
12.90Single6K1QIRL25006K1Q-ETB-IRL2500
12.90Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.90Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
12.90Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.90Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
12.90Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
12.90Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
12.90Single8XWFCXCL38XWF-CXCR2-CXCL3
12.90Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single4XNWMRS25004XNW-P2Y1-MRS2500
12.50Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.50Single6KNMJN241-96KNM-Apelin-JN241-9
12.50Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
12.50Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.50Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.50Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
12.50Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
12.50Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
12.50Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
12.50Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
12.50Single8XQJJN2418XQJ-Apelin-JN241
12.50Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
12.50Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.50Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.50Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusgi_sensoryOrthosteric Ligandgi_opsins
12.50Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.50Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
12.50Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
12.12Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
12.12Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
12.12Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.12Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.12Single8KIGSHU91198KIG-MC3-SHU9119-Ca
12.12Single8WKYPG-9348WKY-MC4-PG-934
12.12Single8XWNCXCL88XWN-CXCR2-CXCL8
12.12Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
12.12Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.12Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.12Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.12Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.12Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.12Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
12.12Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.12Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
12.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
12.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
12.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
12.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
12.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.00Single5L7IVismodegib5L7I-SMO-Vismodegib
12.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
12.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
12.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
12.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
12.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
12.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
12.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
12.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
12.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
12.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
12.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.76Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.76Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.76Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
11.54Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.54Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.54Single3ODUIT1t3ODU-CXCR4-IT1t
11.54Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
11.54Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
11.54Single4QINSAG1.54QIN-SMO-SAG1.5
11.54Single5WS3EMPA5WS3-OX2-EMPA
11.54Single6DS0Ly2660976DS0-5-HT2B-Ly266097
11.54Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.54Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.54Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.54Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.54Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.54Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.54Single7F8ULintitript7F8U-CCKA-Lintitript
11.54Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.54Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
11.54Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.54Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.54Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
11.54Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
11.54Single7XRRLemborexant7XRR-OX2-Lemborexant
11.54Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
11.54Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
11.54Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
11.54Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
11.54Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.54Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
11.54Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
11.54Single8Y0HVUF114188Y0H-CXCR3-VUF11418
11.54Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.54Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
11.54Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.54Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.54Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.54Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.54Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
11.54Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.54Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.43Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.43Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.43Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.11Single3REYXAC3REY-A2A-XAC
11.11Single3RZECidoxepin3RZE-H1-Cidoxepin
11.11Single5UVIZM-2413855UVI-A2A-ZM-241385
11.11Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.11Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.11Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
11.11Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
11.11Single6V9SGTPL114036V9S-OX1-GTPL11403
11.11Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
11.11Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.11Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
11.11Single6ZG9GSK10347026ZG9-M1-GSK1034702
11.11Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
11.11Single7VODCariprazine7VOD-5-HT2A-Cariprazine
11.11Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
11.11Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
11.11Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
11.11Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
11.11Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
11.11Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
11.11Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
11.11Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
11.11Consensusgrh_offOrthosteric Ligandgnrh1_off
11.11Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.71Single5DHGC-355DHG-NOP-C-35
10.71Single5DSGTiotropium5DSG-M4-Tiotropium
10.71Single5T04Neurotensin5T04-NTS1-Neurotensin
10.71Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
10.71Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
10.71Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.71Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
10.71Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.71Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
10.71Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
10.71Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
10.71Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
10.71Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
10.71Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
10.71Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.71Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
10.71Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
10.71Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.53Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.34Single4NTJAZD12834NTJ-P2Y12-AZD1283
10.34Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
10.34Single5CGCHTL142425CGC-mGlu5-HTL14242
10.34Single6HLPNetupitant6HLP-NK1-Netupitant
10.34Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.34Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.34Single7SINNPS-21437SIN-CaS-NPS-2143
10.34Single7SINNPS-21437SIN-CaS-NPS-2143
10.34Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.34Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.34Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
10.34Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
10.34Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
10.34Consensusblt_offOrthosteric Ligandblt1_off
10.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
10.00Single5TZRMK86665TZR-FFA1-MK8666
10.00Single6E59L-7607356E59-NK1-L-760735
10.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
10.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
10.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
10.00Single9BJKNAM9BJK-μ-Naloxone-NAM
10.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
9.68Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.68Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.68Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
9.68Single7K15MKD0467K15-BLT1-MKD046-Na
9.68Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.68Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8XWACXCL18XWA-CXCR2-CXCL1
9.68Single8XWSCXCL58XWS-CXCR2-CXCL5
9.68Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
9.68Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
9.68Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
9.52Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
9.38Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
9.38Single5CGDHTL142425CGD-mGlu5-HTL14242
9.38Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.38Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
9.38Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
9.38Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
9.38Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
9.09Single5MZPCaffeine5MZP-A2A-Caffeine-Na
9.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.82Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
8.70Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
8.70Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
8.70Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.57Single7SHEPI; PE7SHE-GPR158-PI; PE
8.57Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
8.33Single3OE8IT1t3OE8-CXCR4-IT1t
8.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.11Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single3UZAGTPL92363UZA-A2A-GTPL9236
8.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
8.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
8.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
8.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
7.69Single6TP4ACT-4622066TP4-OX1-ACT-462206
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
7.69Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.69Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.69Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.69Consensusgq_nucleotideOrthosteric Ligandgq_p2y
7.69Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.41Single4S0VSuvorexant4S0V-OX2-Suvorexant
7.41Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
7.41Single6TPJSuvorexant6TPJ-OX2-Suvorexant
7.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
7.41Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
7.41Single7F8YDevazepide7F8Y-CCKA-Devazepide
7.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.41Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
7.41Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
7.41Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
7.14Single6IQLL7458706IQL-D4-L745870
7.14Single6TP3Nemorexant6TP3-OX1-Nemorexant
7.14Single6TPKRetosiban6TPK-OT-Retosiban
7.14Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
7.14Single7VV6C48/807VV6-MRGPRX2-C48/80
7.14Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
7.14Consensusvasop-oxy_offOrthosteric Ligandot_off
6.90Single7F83PF-051904577F83-Ghrelin-PF-05190457
6.90Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
6.90Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
6.90Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
6.90Consensuscck_offOrthosteric Ligandccka_off
6.90Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
6.90Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
6.90Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
6.90Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
6.67Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
6.67Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
6.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
6.67Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
6.67Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
6.45Single7P2L4YI7P2L-mGlu5-4YI
6.45Single7R0CAVP7R0C-V2-AVP-Arrestin2
6.45Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.45Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.25Single5X33BIIL2605X33-BLT1-BIIL260
6.25Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.25Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
6.25Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.25Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.71Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6D35Cholesterol6D35-SMO-Cholesterol
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.00Single7XW7K1-707XW7-TSH-K1-70
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WVXNorrin8WVX-LGR4-Norrin
5.00Single8WVYNorrin8WVY-LGR4-Norrin
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.55Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.55Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.35Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
4.35Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
4.35Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.35Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.35Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.35Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.35Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.35Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single5L7DCholesterol5L7D-SMO-Cholesterol
4.17Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.17Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.85Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.85Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.85Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.85Single8JPSCCL78JPS-ACKR1-CCL7
3.85Single8ZPLCholesterol8ZPL-CXCR4-HF51116-Cholesterol
3.85Single8ZPMCholesterol8ZPM-CXCR4-AMD070-Cholesterol
3.70Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.70Single7UL2SR486927UL2-NTS1-SR48692-Na
3.70Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
3.70Single8HNNSCH5467388HNN-CXCR3-SCH546738
3.70Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensusneurotensin_offOrthosteric Ligandnts1_off
3.70Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
3.57Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.45Single6ZINSR486926ZIN-NTS1-SR48692
3.45Single8IYXYL-3658IYX-GPR34-YL-365
3.45Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.33Single6FFHFenobam6FFH-mGlu5-Fenobam
3.23Single6Z4SSR486926Z4S-NTS1-SR48692
3.23Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
3.23Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.23Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.23Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.12Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single7SHEPI; PE7SHE-GPR158-PI; PE
2.94Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.78Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.78Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.63Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.56Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.38Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 6WI9
Class B1
SubFamily Peptide
Type Glucagon
SubType Secretin
Species Homo Sapiens
Ligand Secretin
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 4.3
Date 2020-08-12
D.O.I. 10.1038/s41467-020-17791-4
Net Summary
Imin 2.34
Number of Linked Nodes 921
Number of Links 1110
Number of Hubs 172
Number of Links mediated by Hubs 620
Number of Communities 37
Number of Nodes involved in Communities 279
Number of Links involved in Communities 383
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 2076248
Length Of Smallest Path 3
Average Path Length 37.2548
Length of Longest Path 76
Minimum Path Strength 1.215
Average Path Strength 5.75717
Maximum Path Strength 24.925
Minimum Path Correlation 0.72
Average Path Correlation 0.992065
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.81818
Average % Of Corr. Nodes 55.6564
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.7347
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • signaling receptor binding   • molecular transducer activity   • molecular function activator activity   • signaling receptor activity   • signaling receptor activator activity   • hormone activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • G protein-coupled receptor binding   • digestive hormone activity   • head development   • central nervous system development   • brain development   • nervous system development   • response to nutrient levels   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • response to dietary excess   • diet induced thermogenesis   • metabolic process   • energy homeostasis   • forebrain development   • pallium development   • telencephalon development   • hippocampus development   • limbic system development   • regulation of localization   • transport   • digestive system process   • regulation of system process   • negative regulation of biological process   • negative regulation of gastrin-induced gastric acid secretion   • negative regulation of transport   • localization   • negative regulation of secretion   • gastrin-induced gastric acid secretion   • regulation of gastrin-induced gastric acid secretion   • regulation of multicellular organismal process   • negative regulation of digestive system process   • regulation of gastric acid secretion   • secretion   • regulation of transport   • acid secretion   • regulation of digestive system process   • gastric acid secretion   • establishment of localization   • regulation of secretion   • digestion   • negative regulation of multicellular organismal process   • negative regulation of gastric acid secretion   • regulation of body fluid levels   • secretion by tissue   • pancreatic juice secretion   • body fluid secretion   • regulation of biological quality   • positive regulation of biological process   • positive regulation of secretion   • positive regulation of digestive system process   • positive regulation of pancreatic juice secretion   • regulation of pancreatic juice secretion   • positive regulation of transport   • positive regulation of multicellular organismal process   • regulation of synaptic plasticity   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • regulation of appetite   • digestive system development   • tube development   • embryo development   • digestive tract development   • embryonic organ development   • embryonic digestive tract development   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of cAMP/PKA signal transduction   • positive regulation of response to stimulus   • cAMP/PKA signal transduction   • regulation of intracellular signal transduction   • positive regulation of cellular process   • positive regulation of intracellular signal transduction   • regulation of cAMP/PKA signal transduction   • regulation of response to stimulus   • positive regulation of signaling   • lipid catabolic process   • catabolic process   • regulation of lipid metabolic process   • primary metabolic process   • regulation of catabolic process   • regulation of lipid catabolic process   • regulation of primary metabolic process   • positive regulation of catabolic process   • positive regulation of metabolic process   • positive regulation of lipid catabolic process   • positive regulation of lipid metabolic process   • regulation of metabolic process   • lipid metabolic process   • nitrogen compound transport   • regulation of hormone secretion   • regulation of peptide secretion   • positive regulation of secretion by cell   • positive regulation of somatostatin secretion   • hormone secretion   • somatostatin secretion   • peptide secretion   • secretion by cell   • regulation of secretion by cell   • positive regulation of hormone secretion   • amide transport   • signal release   • regulation of peptide hormone secretion   • positive regulation of peptide secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • regulation of peptide transport   • export from cell   • peptide transport   • regulation of somatostatin secretion   • peptide hormone secretion   • hormone transport   • regulation of cellular component size   • cell volume homeostasis   • cellular component organization   • cellular homeostasis   • intracellular water homeostasis   • chemical homeostasis   • intracellular chemical homeostasis   • cellular component organization or biogenesis   • regulation of cell size   • regulation of anatomical structure size   • amide binding   • peptide hormone binding   • hormone binding   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • secretin receptor activity   • peptide receptor activity   • G protein-coupled peptide receptor activity   • cell surface receptor signaling pathway   • basal part of cell   • basal plasma membrane   • plasma membrane region   • basolateral plasma membrane   • polymeric cytoskeletal fiber   • intracellular membraneless organelle   • cytoplasmic microtubule   • cytoskeleton   • membraneless organelle   • supramolecular fiber   • microtubule   • supramolecular polymer   • supramolecular complex   • microtubule cytoskeleton
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>6WI9_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG SGIFETKFQ 
VDKVNFHMF DVGAQRDER RKWIQCFND VTAIIFVVA NRLQAALKL 
FDSIWNNKW LRDTSVILF LNKQDIEDY FPEFARYTT PEDATPEPG 
EDPRVTRAK YFIRDEFLR ISTASGDGR HYCYPHFTN IRRVFNDCR 
DIIQRMHLR QYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>6WI9_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>6WI9_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP47872
Sequence
>6WI9_Chain_R
RLCDVLQVL WEEQDQCLQ ELSREQTGD LGTEQPVPG CEGMWDNIS 
CWPSSVPGR MVEVECPRF LRMLTSRNG SLFRNCTQD GWSETFPRP 
NLACGVNVN DSSNEKRHS YLLKLKVMY TVGYSSSLV MLLVALGIL 
CAFRRLHCT RNYIHMHLF VSFILRALS NFIKDAVLF RAGCKLVMV 
LFQYCIMAN YSWLLVEGL YLHTLLAIS FFSERKYLQ GFVAFGWGS 
PAIFVALWA IARHFLEDV GCWDINANA SIWWIIRGP VILSILINF 
ILFINILRI LMRKLRTQE TRGNEVSHY KRLARSTLL LIPLFGIHY 
IVFAFSPED AMEIQLFFE LALGSFQGL VVAVLYCFL NGEVQLEVQ 
KKWQQWHL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-0410.1016/j.bbrc.2020.08.042
7D3S (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.92020-11-0410.1016/j.bbrc.2020.08.042
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.32020-08-1210.1038/s41467-020-17791-4
6WZG (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.32020-08-1210.1038/s41467-020-17791-4
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ24.32020-08-1210.1038/s41467-020-17791-4
6WI9 (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-4.32020-08-1210.1038/s41467-020-17791-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6WI9.zip



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