psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D3	L:L:H1	2.52	Yes	Yes	1	0	0
2	L:L:G4	L:L:H1	6.35	No	Yes	0	0	0
3	L:L:H1	R:R:Q223	2.47	Yes	Yes	1	0	7
4	L:L:H1	R:R:I226	11.93	Yes	Yes	1	0	6
5	L:L:H1	R:R:I298	2.65	Yes	Yes	1	0	7
6	L:L:H1	R:R:V302	2.77	Yes	Yes	0	0	6
7	L:L:S2	R:R:E373	12.94	No	No	0	0	7
8	L:L:S2	R:R:L374	3	No	Yes	0	0	7
9	L:L:D3	L:L:F6	2.39	Yes	Yes	1	0	0
10	L:L:D3	R:R:N192	6.73	Yes	Yes	1	0	8
11	L:L:D3	R:R:F222	8.36	Yes	Yes	1	0	6
12	L:L:D3	R:R:I226	5.6	Yes	Yes	1	0	6
13	L:L:G4	R:R:W295	2.81	No	Yes	0	0	6
14	L:L:T5	R:R:W295	2.43	No	Yes	0	0	6
15	L:L:F6	L:L:L10	3.65	Yes	No	1	0	0
16	L:L:F6	R:R:L139	2.44	Yes	Yes	1	0	4
17	L:L:F6	R:R:L142	3.65	Yes	No	0	0	6
18	L:L:F6	R:R:Y146	5.16	Yes	Yes	1	0	7
19	L:L:F6	R:R:L370	6.09	Yes	No	0	0	6
20	L:L:S8	R:R:N289	8.94	No	No	0	0	6
21	L:L:E9	L:L:R12	8.14	No	No	0	0	0
22	L:L:L10	R:R:L139	6.92	No	Yes	1	0	4
23	L:L:L10	R:R:F200	7.31	No	No	0	0	4
24	L:L:S11	R:R:D287	2.94	No	No	0	0	6
25	L:L:L13	R:R:R135	9.72	Yes	No	0	0	3
26	L:L:L13	R:R:H136	6.43	Yes	No	0	0	1
27	L:L:R14	L:L:R18	3.2	No	No	0	0	0
28	L:L:E15	R:R:R30	3.49	No	No	0	0	6
29	L:L:E15	R:R:L31	5.3	No	Yes	0	0	4
30	L:L:R18	R:R:L31	3.64	No	Yes	0	0	4
31	L:L:L19	R:R:L31	4.15	No	Yes	0	0	4
32	L:L:Q20	L:L:Q24	7.68	No	No	7	0	0
33	L:L:L23	L:L:Q24	3.99	No	No	0	0	0
34	L:L:L23	L:L:V27	4.47	No	Yes	0	0	0
35	L:L:L26	R:R:I73	2.85	No	Yes	0	0	5
36	L:L:V27	R:R:I73	7.68	Yes	Yes	2	0	5
37	L:L:V27	R:R:L121	2.98	Yes	Yes	2	0	5
38	L:L:V27	R:R:A122	5.09	Yes	No	2	0	5
39	R:R:L31	R:R:L35	4.15	Yes	No	0	4	2
40	R:R:D33	R:R:Q36	3.92	No	No	0	6	2
41	R:R:D33	R:R:F92	2.39	No	Yes	0	6	5
42	R:R:V34	R:R:V37	3.21	No	No	8	4	5
43	R:R:F92	R:R:V34	7.87	Yes	No	8	5	4
44	R:R:E40	R:R:Q36	2.55	No	No	0	4	2
45	R:R:E40	R:R:V37	8.56	No	No	0	4	5
46	R:R:F92	R:R:V37	23.6	Yes	No	8	5	5
47	R:R:L38	R:R:Q42	5.32	No	No	0	6	5
48	R:R:E41	R:R:Q44	7.65	No	No	0	6	4
49	R:R:Q42	R:R:W70	6.57	No	Yes	0	5	7
50	R:R:N72	R:R:Q42	6.6	No	No	0	4	5
51	R:R:D43	R:R:Q44	2.61	No	No	0	3	4
52	R:R:C45	R:R:W70	9.14	No	Yes	9	9	7
53	R:R:C45	R:R:C75	7.28	No	No	9	9	9
54	R:R:L46	R:R:W70	6.83	No	Yes	0	3	7
55	R:R:E48	R:R:E52	7.61	No	Yes	10	3	3
56	R:R:L49	R:R:M69	4.24	No	No	0	5	5
57	R:R:L49	R:R:W70	4.56	No	Yes	0	5	7
58	R:R:S50	R:R:T54	3.2	No	No	0	1	3
59	R:R:G55	R:R:R51	3	No	Yes	0	3	2
60	R:R:E52	R:R:G68	3.27	Yes	No	0	3	4
61	R:R:E52	R:R:P77	3.14	Yes	No	0	3	4
62	R:R:E67	R:R:Q53	15.29	No	No	11	4	2
63	R:R:M69	R:R:Q53	4.08	No	No	11	5	2
64	R:R:G55	R:R:T54	3.64	No	No	0	3	3
65	R:R:G58	R:R:P62	6.09	No	No	0	1	2
66	R:R:E60	R:R:V80	2.85	No	No	0	1	1
67	R:R:P81	R:R:Q61	11.05	Yes	No	0	4	2
68	R:R:P64	R:R:V63	5.3	No	No	0	1	1
69	R:R:P81	R:R:V63	7.07	Yes	No	0	4	1
70	R:R:C107	R:R:C66	5.46	No	No	0	9	9
71	R:R:C66	R:R:G111	3.92	No	Yes	0	9	9
72	R:R:E67	R:R:M69	2.71	No	No	11	4	5
73	R:R:C75	R:R:W70	11.75	No	Yes	9	9	7
74	R:R:D71	R:R:I73	5.6	No	Yes	0	9	5
75	R:R:E114	R:R:I73	5.47	No	Yes	2	2	5
76	R:R:I73	R:R:T115	3.04	Yes	Yes	2	5	4
77	R:R:V87	R:R:W76	4.9	No	No	0	5	9
78	R:R:R105	R:R:W76	4	Yes	No	0	8	9
79	R:R:S79	R:R:V85	9.7	No	No	0	7	7
80	R:R:P81	R:R:V80	5.3	Yes	No	0	4	1
81	R:R:F104	R:R:M84	6.22	No	No	0	5	4
82	R:R:M84	R:R:N106	5.61	No	No	0	4	3
83	R:R:C107	R:R:V85	6.83	No	No	0	9	7
84	R:R:E86	R:R:S102	2.87	No	No	0	3	3
85	R:R:C89	R:R:P90	3.77	Yes	No	5	9	8
86	R:R:C89	R:R:L103	4.76	Yes	Yes	5	9	7
87	R:R:C123	R:R:C89	7.28	No	Yes	5	9	9
88	R:R:L93	R:R:P90	11.49	No	No	0	5	8
89	R:R:C123	R:R:P90	3.77	No	No	5	9	8
90	R:R:R91	R:R:R94	5.33	No	No	0	2	4
91	R:R:L93	R:R:L96	4.15	No	No	0	5	5
92	R:R:N100	R:R:R94	4.82	No	No	0	3	4
93	R:R:L103	R:R:R99	3.64	Yes	No	0	7	3
94	R:R:C123	R:R:L103	4.76	No	Yes	5	9	7
95	R:R:R105	R:R:W112	24.99	Yes	Yes	2	8	9
96	R:R:R105	R:R:S113	5.27	Yes	No	0	8	5
97	R:R:F116	R:R:R105	11.76	Yes	Yes	2	4	8
98	R:R:P117	R:R:R105	5.76	No	Yes	2	4	8
99	R:R:N106	R:R:W112	24.86	No	Yes	2	3	9
100	R:R:F116	R:R:N106	9.67	Yes	No	2	4	3
101	R:R:Q109	R:R:T108	2.83	No	No	0	3	5
102	R:R:G111	R:R:W112	2.81	Yes	Yes	0	9	9
103	R:R:F116	R:R:W112	25.05	Yes	Yes	2	4	9
104	R:R:E114	R:R:T115	8.47	No	Yes	2	2	4
105	R:R:L121	R:R:T115	2.95	Yes	Yes	2	5	4
106	R:R:F116	R:R:P117	2.89	Yes	No	2	4	4
107	R:R:F116	R:R:R118	12.83	Yes	No	0	4	6
108	R:R:P119	R:R:R118	8.65	No	No	0	8	6
109	R:R:N120	R:R:R118	3.62	No	No	0	5	6
110	R:R:A122	R:R:L121	3.15	No	Yes	2	5	5
111	R:R:N128	R:R:V125	7.39	No	No	0	4	3
112	R:R:N126	R:R:V127	5.91	No	No	0	3	2
113	R:R:D129	R:R:V127	2.92	No	No	0	2	2
114	R:R:D129	R:R:N132	16.16	No	No	0	2	3
115	R:R:D129	R:R:E133	18.19	No	No	0	2	2
116	R:R:R135	R:R:S131	9.22	No	No	0	3	2
117	R:R:I368	R:R:Y138	3.63	No	No	0	4	4
118	R:R:L142	R:R:L374	5.54	No	Yes	0	6	7
119	R:R:K143	R:R:Y146	2.39	No	Yes	0	5	7
120	R:R:T147	R:R:Y146	8.74	No	Yes	0	6	7
121	R:R:Y146	R:R:Y150	3.97	Yes	Yes	1	7	7
122	R:R:N192	R:R:Y146	3.49	Yes	Yes	1	8	7
123	R:R:L374	R:R:Y146	3.52	Yes	Yes	0	7	7
124	R:R:S378	R:R:Y146	2.54	No	Yes	1	9	7
125	R:R:S151	R:R:V148	3.23	No	No	0	6	5
126	R:R:F379	R:R:G149	6.02	No	No	0	7	8
127	R:R:R188	R:R:Y150	7.2	No	Yes	0	8	7
128	R:R:A189	R:R:Y150	4	No	Yes	0	8	7
129	R:R:N192	R:R:Y150	6.98	Yes	Yes	1	8	7
130	R:R:S378	R:R:Y150	7.63	No	Yes	1	9	7
131	R:R:L154	R:R:L190	6.92	No	No	0	6	4
132	R:R:L382	R:R:M156	4.24	No	No	0	5	6
133	R:R:A385	R:R:M156	3.22	No	No	0	8	6
134	R:R:M156	R:R:V386	3.04	No	No	0	6	5
135	R:R:F182	R:R:L157	4.87	Yes	No	0	8	9
136	R:R:I186	R:R:L157	4.28	No	No	0	7	9
137	R:R:A385	R:R:L157	3.15	No	No	0	8	9
138	R:R:A160	R:R:C389	3.61	No	No	0	9	8
139	R:R:L161	R:R:M179	2.83	No	No	0	6	6
140	R:R:F182	R:R:L161	3.65	Yes	No	0	8	6
141	R:R:F167	R:R:I163	3.77	No	No	0	7	8
142	R:R:L164	R:R:N175	15.1	No	No	0	8	8
143	R:R:E398	R:R:F167	12.83	Yes	No	0	8	7
144	R:R:E398	R:R:R169	9.3	Yes	No	0	8	7
145	R:R:K402	R:R:R169	4.95	No	No	0	4	7
146	R:R:E394	R:R:L170	2.65	No	No	0	9	9
147	R:R:E398	R:R:L170	6.63	Yes	No	0	8	9
148	R:R:H171	R:R:N175	11.48	No	No	0	7	8
149	R:R:H171	R:R:Y176	15.24	No	No	0	7	6
150	R:R:C172	R:R:R174	2.79	No	No	0	8	9
151	R:R:T173	R:R:Y239	4.99	No	Yes	0	7	8
152	R:R:R252	R:R:T173	10.35	No	No	0	4	7
153	R:R:N175	R:R:R174	8.44	No	No	0	8	9
154	R:R:N392	R:R:R174	7.23	No	No	0	9	9
155	R:R:L255	R:R:Y176	3.52	No	No	0	5	6
156	R:R:E236	R:R:I177	2.73	Yes	No	0	9	9
157	R:R:I177	R:R:Y239	7.25	No	Yes	0	9	8
158	R:R:F182	R:R:H178	4.53	Yes	No	0	8	9
159	R:R:H178	R:R:L350	2.57	No	Yes	3	9	8
160	R:R:H178	R:R:Y388	5.44	No	Yes	3	9	8
161	R:R:H180	R:R:W232	15.87	No	Yes	6	8	9
162	R:R:H180	R:R:V259	4.15	No	No	6	8	5
163	R:R:H180	R:R:W263	6.35	No	Yes	6	8	9
164	R:R:F185	R:R:L181	3.65	Yes	No	0	8	9
165	R:R:L181	R:R:L233	5.54	No	No	0	9	9
166	R:R:F182	R:R:V384	2.62	Yes	Yes	0	8	9
167	R:R:L187	R:R:V183	2.98	No	No	0	6	4
168	R:R:N229	R:R:S184	4.47	Yes	No	0	8	9
169	R:R:F185	R:R:N229	14.5	Yes	Yes	0	8	8
170	R:R:F185	R:R:Q380	4.68	Yes	Yes	3	8	9
171	R:R:F185	R:R:G381	4.52	Yes	No	0	8	9
172	R:R:F185	R:R:V384	3.93	Yes	Yes	3	8	9
173	R:R:I186	R:R:L190	2.85	No	No	0	7	4
174	R:R:N229	R:R:R188	7.23	Yes	No	0	8	8
175	R:R:R188	R:R:Y355	3.09	No	Yes	0	8	8
176	R:R:F222	R:R:S191	5.28	Yes	No	0	6	5
177	R:R:F222	R:R:N192	7.25	Yes	Yes	1	6	8
178	R:R:K195	R:R:V218	3.04	No	No	0	7	6
179	R:R:K195	R:R:M219	7.2	No	No	0	7	6
180	R:R:F222	R:R:K195	7.44	Yes	No	0	6	7
181	R:R:F200	R:R:L199	8.53	No	No	0	4	6
182	R:R:C215	R:R:C285	7.28	No	No	12	9	9
183	R:R:K216	R:R:R277	6.19	No	No	0	8	7
184	R:R:V220	R:R:W273	3.68	No	Yes	0	6	8
185	R:R:A274	R:R:V220	3.39	No	No	0	5	6
186	R:R:F222	R:R:Q223	5.86	Yes	Yes	1	6	7
187	R:R:F222	R:R:I226	7.54	Yes	Yes	1	6	6
188	R:R:Q223	R:R:W273	4.38	Yes	Yes	1	7	8
189	R:R:I298	R:R:Q223	2.74	Yes	Yes	1	7	7
190	R:R:P266	R:R:Y224	8.34	Yes	Yes	0	9	8
191	R:R:V270	R:R:Y224	3.79	No	Yes	0	7	8
192	R:R:I226	R:R:Y230	2.42	Yes	No	0	6	8
193	R:R:M227	R:R:P266	3.35	No	Yes	0	6	9
194	R:R:M227	R:R:P301	3.35	No	No	0	6	9
195	R:R:M227	R:R:V302	3.04	No	Yes	0	6	6
196	R:R:L233	R:R:N229	4.12	No	Yes	0	9	8
197	R:R:V302	R:R:Y230	5.05	Yes	No	0	6	8
198	R:R:Y230	R:R:Y355	19.86	No	Yes	0	8	8
199	R:R:S231	R:R:S265	3.26	No	No	13	5	4
200	R:R:P266	R:R:S231	5.34	Yes	No	13	9	5
201	R:R:V235	R:R:W232	6.13	No	Yes	0	8	9
202	R:R:G262	R:R:W232	5.63	No	Yes	0	8	9
203	R:R:W232	R:R:W263	14.99	Yes	Yes	6	9	9
204	R:R:L234	R:R:S305	3	No	No	0	8	7
205	R:R:I308	R:R:L234	2.85	No	No	0	6	8
206	R:R:L234	R:R:N309	8.24	No	No	0	8	9
207	R:R:F258	R:R:V235	3.93	No	No	0	7	8
208	R:R:F261	R:R:V235	2.62	No	No	0	5	8
209	R:R:E236	R:R:G237	3.27	Yes	No	0	9	8
210	R:R:E236	R:R:L240	2.65	Yes	No	0	9	9
211	R:R:E236	R:R:L350	13.25	Yes	Yes	0	9	8
212	R:R:F351	R:R:G237	4.52	Yes	No	0	9	8
213	R:R:L238	R:R:T242	2.95	No	No	0	6	7
214	R:R:L238	R:R:L312	2.77	No	No	0	6	8
215	R:R:L243	R:R:Y239	3.52	No	Yes	0	8	8
216	R:R:F258	R:R:Y239	6.19	No	Yes	0	7	8
217	R:R:L240	R:R:L244	2.77	No	No	0	9	8
218	R:R:I316	R:R:L240	4.28	No	No	0	8	9
219	R:R:A245	R:R:H241	4.39	No	Yes	0	6	8
220	R:R:H241	R:R:L312	10.29	Yes	No	0	8	8
221	R:R:H241	R:R:N315	3.83	Yes	No	0	8	7
222	R:R:H241	R:R:I316	5.3	Yes	No	0	8	8
223	R:R:F258	R:R:T242	2.59	No	No	0	7	7
224	R:R:L243	R:R:S250	3	No	No	0	8	6
225	R:R:F249	R:R:I246	11.3	No	No	0	6	4
226	R:R:F249	R:R:Y254	8.25	No	No	0	6	4
227	R:R:E251	R:R:K253	12.15	No	No	14	6	6
228	R:R:E251	R:R:Y254	5.61	No	No	14	6	4
229	R:R:L255	R:R:R252	2.43	No	No	0	5	4
230	R:R:K253	R:R:Y254	5.97	No	No	14	6	4
231	R:R:V259	R:R:W263	2.45	No	Yes	6	5	9
232	R:R:P266	R:R:S265	3.56	Yes	No	13	9	4
233	R:R:F269	R:R:S265	2.64	No	No	0	6	4
234	R:R:F269	R:R:P301	15.89	No	No	0	6	9
235	R:R:I275	R:R:L272	2.85	No	No	0	4	4
236	R:R:W273	R:R:W286	2.81	Yes	Yes	1	8	9
237	R:R:I297	R:R:W273	5.87	No	Yes	0	8	8
238	R:R:I298	R:R:W273	10.57	Yes	Yes	1	7	8
239	R:R:D282	R:R:R277	8.34	No	No	1	6	7
240	R:R:R277	R:R:W286	23.99	No	Yes	1	7	9
241	R:R:D282	R:R:H278	12.61	No	No	0	6	2
242	R:R:I294	R:R:L280	2.85	No	No	0	4	3
243	R:R:D282	R:R:W286	6.7	No	Yes	1	6	9
244	R:R:I294	R:R:W286	4.7	No	Yes	0	4	9
245	R:R:N289	R:R:W295	5.65	No	Yes	0	6	6
246	R:R:N291	R:R:S293	5.96	No	No	0	5	1
247	R:R:I294	R:R:N291	5.66	No	No	0	4	5
248	R:R:A292	R:R:R299	2.77	No	No	0	5	6
249	R:R:I298	R:R:W295	9.4	Yes	Yes	0	7	6
250	R:R:R299	R:R:W296	6	No	No	0	6	7
251	R:R:G300	R:R:W296	4.22	No	No	0	4	7
252	R:R:G300	R:R:P301	4.06	No	No	0	4	9
253	R:R:S305	R:R:V302	3.23	No	Yes	0	7	6
254	R:R:I306	R:R:V302	3.07	No	Yes	0	7	6
255	R:R:I306	R:R:Y355	3.63	No	Yes	0	7	8
256	R:R:I306	R:R:I356	4.42	No	No	0	7	5
257	R:R:I308	R:R:L312	2.85	No	No	0	6	8
258	R:R:F351	R:R:N309	2.42	Yes	No	0	9	9
259	R:R:F310	R:R:I314	3.77	No	No	0	7	4
260	R:R:F310	R:R:I353	5.02	No	No	0	7	5
261	R:R:F313	R:R:T344	2.59	No	No	0	9	8
262	R:R:F313	R:R:L347	6.09	No	No	3	9	9
263	R:R:F313	R:R:F351	4.29	No	Yes	3	9	9
264	R:R:F351	R:R:I316	3.77	Yes	No	0	9	8
265	R:R:L317	R:R:T344	4.42	No	No	0	6	8
266	R:R:R318	R:R:R322	9.6	No	No	0	7	7
267	R:R:L320	R:R:L340	2.77	No	No	0	8	8
268	R:R:L320	R:R:S343	3	No	No	0	8	9
269	R:R:L340	R:R:M321	4.24	No	No	0	8	5
270	R:R:L324	R:R:R325	2.43	No	No	15	7	6
271	R:R:L324	R:R:N332	2.75	No	No	0	7	6
272	R:R:H336	R:R:L324	3.86	Yes	No	15	6	7
273	R:R:H336	R:R:R325	3.39	Yes	No	15	6	6
274	R:R:N332	R:R:R339	6.03	No	No	0	6	8
275	R:R:K338	R:R:S335	4.59	No	No	0	6	6
276	R:R:H336	R:R:L340	2.57	Yes	No	0	6	8
277	R:R:A341	R:R:Y337	4	No	No	0	7	7
278	R:R:L346	R:R:L387	8.3	No	No	0	8	7
279	R:R:F351	R:R:L347	9.74	Yes	No	3	9	9
280	R:R:I348	R:R:P349	3.39	No	No	0	7	8
281	R:R:I348	R:R:I353	4.42	No	No	0	7	5
282	R:R:P349	R:R:Q380	3.16	No	Yes	0	8	9
283	R:R:P349	R:R:V383	5.3	No	No	0	8	6
284	R:R:F351	R:R:L350	2.44	Yes	Yes	3	9	8
285	R:R:L350	R:R:Y388	14.07	Yes	Yes	3	8	8
286	R:R:G352	R:R:H354	3.18	No	Yes	0	9	8
287	R:R:I353	R:R:I356	4.42	No	No	0	5	5
288	R:R:H354	R:R:Y355	10.89	Yes	Yes	0	8	8
289	R:R:H354	R:R:Q380	7.42	Yes	Yes	0	8	9
290	R:R:E373	R:R:Y355	11.22	No	Yes	0	7	8
291	R:R:A359	R:R:I356	3.25	No	No	0	6	5
292	R:R:F358	R:R:V357	3.93	Yes	No	4	7	5
293	R:R:F372	R:R:V357	2.62	No	No	4	5	5
294	R:R:F358	R:R:S361	3.96	Yes	Yes	4	7	5
295	R:R:F358	R:R:M366	3.73	Yes	No	4	7	5
296	R:R:F358	R:R:Q369	5.86	Yes	Yes	4	7	7
297	R:R:F358	R:R:F372	11.79	Yes	No	4	7	5
298	R:R:P362	R:R:S361	3.56	No	Yes	0	6	5
299	R:R:M366	R:R:S361	3.07	No	Yes	4	5	5
300	R:R:Q369	R:R:S361	4.33	Yes	Yes	4	7	5
301	R:R:M366	R:R:Q369	2.72	No	Yes	4	5	7
302	R:R:E373	R:R:Q369	5.1	No	Yes	0	7	7
303	R:R:L370	R:R:L374	4.15	No	Yes	0	6	7
304	R:R:A375	R:R:F371	4.16	No	No	0	6	6
305	R:R:F379	R:R:S378	3.96	No	No	0	7	9
306	R:R:F379	R:R:L382	3.65	No	No	0	7	5
307	R:R:Q380	R:R:V384	2.87	Yes	Yes	3	9	9
308	R:R:V384	R:R:Y388	2.52	Yes	Yes	3	9	8
309	R:R:F390	R:R:V386	2.62	No	No	0	8	5
310	R:R:L387	R:R:Y388	9.38	No	Yes	0	7	8
311	R:R:E394	R:R:N392	3.94	No	No	0	9	9
312	R:R:N392	R:R:V395	4.43	No	No	0	9	9
313	R:R:G393	R:R:Q396	8.22	No	No	0	4	7
314	R:R:L397	R:R:Q400	3.99	No	No	0	4	5
315	R:R:W403	R:R:W406	6.56	No	No	0	4	4
316	R:R:H407	R:R:W406	5.29	No	No	0	4	4
317	R:R:I288	R:R:W286	2.35	No	Yes	0	5	9
318	R:R:L139	R:R:Y138	2.34	Yes	No	0	4	4
319	R:R:E48	R:R:R51	2.33	No	Yes	10	3	2
320	R:R:E52	R:R:R51	2.33	Yes	Yes	10	3	2
321	R:R:L187	R:R:W263	2.28	No	Yes	0	6	9
322	R:R:G82	R:R:P81	2.03	No	Yes	0	6	4
323	R:R:C165	R:R:G162	1.96	No	No	0	2	1
324	R:R:A267	R:R:G264	1.95	No	No	0	3	7
325	R:R:A228	R:R:P266	1.87	No	Yes	0	7	9
326	R:R:A365	R:R:P362	1.87	No	No	0	3	6
327	R:R:G68	R:R:S78	1.86	No	No	0	4	4
328	R:R:G381	R:R:S153	1.86	No	No	0	9	9
329	R:R:G149	R:R:V148	1.84	No	No	0	8	5
330	L:L:G4	L:L:T7	1.82	No	No	0	0	0
331	R:R:G124	R:R:T97	1.82	No	No	0	3	5
332	R:R:G111	R:R:T108	1.82	Yes	No	0	9	5
333	R:R:A166	R:R:C165	1.81	No	No	0	3	2
334	R:R:A160	R:R:A385	1.79	No	No	0	9	8
335	R:R:G300	R:R:I303	1.76	No	No	0	4	4
336	R:R:P117	R:R:T115	1.75	No	Yes	2	4	4
337	R:R:C225	R:R:S191	1.72	No	No	0	6	5
338	L:L:G16	L:L:L19	1.71	No	No	0	0	0
339	R:R:G124	R:R:L96	1.71	No	No	0	3	5
340	R:R:G377	R:R:L376	1.71	No	No	0	7	6
341	R:R:D110	R:R:G111	1.68	No	Yes	0	5	9
342	R:R:E67	R:R:G68	1.64	No	No	0	4	4
343	R:R:S151	R:R:S152	1.63	No	No	0	6	5
344	R:R:S74	R:R:V87	1.62	No	No	0	5	5
345	R:R:S152	R:R:V155	1.62	No	No	0	5	4
346	R:R:C215	R:R:M219	1.62	No	No	12	9	6
347	R:R:C285	R:R:M219	1.62	No	No	12	9	6
348	R:R:A375	R:R:M145	1.61	No	No	0	6	6
349	R:R:S98	R:R:T97	1.6	No	No	0	3	5
350	R:R:T147	R:R:V144	1.59	No	No	0	6	4
351	R:R:G377	R:R:H354	1.59	No	Yes	0	7	8
352	R:R:P62	R:R:Q61	1.58	No	No	0	2	2
353	R:R:T326	R:R:T329	1.57	No	No	0	6	4
354	R:R:C285	R:R:D287	1.56	No	No	0	9	6
355	R:R:I194	R:R:V198	1.54	No	No	0	5	4
356	R:R:A197	R:R:D196	1.54	No	No	0	4	7
357	R:R:C45	R:R:E41	1.52	No	No	0	9	6
358	R:R:C89	R:R:E88	1.52	Yes	No	0	9	3
359	R:R:G82	R:R:R83	1.5	No	No	0	6	5
360	R:R:G214	R:R:R212	1.5	No	No	0	2	3
361	R:R:G331	R:R:R330	1.5	No	No	0	4	4
362	R:R:L35	R:R:V34	1.49	No	No	0	2	4
363	R:R:L96	R:R:V125	1.49	No	No	0	5	3
364	R:R:N332	R:R:S335	1.49	No	No	0	6	6
365	R:R:L57	R:R:T59	1.47	No	No	0	3	2
366	R:R:I308	R:R:I311	1.47	No	No	0	6	3
367	R:R:I319	R:R:K323	1.45	No	No	0	7	9
368	R:R:E363	R:R:S361	1.44	No	Yes	0	5	5
369	R:R:I186	R:R:L158	1.43	No	No	0	7	4
370	R:R:I319	R:R:L244	1.43	No	No	0	7	8
371	R:R:Q396	R:R:V395	1.43	No	No	0	7	9
372	R:R:E398	R:R:V399	1.43	Yes	No	0	8	4
373	R:R:K143	R:R:L140	1.41	No	No	0	5	3
374	R:R:L317	R:R:M321	1.41	No	No	0	6	5
375	L:L:L13	R:R:L139	1.38	Yes	Yes	0	0	4
376	L:L:L22	R:R:L35	1.38	No	No	0	0	2
377	R:R:D196	R:R:K143	1.38	No	No	0	7	5
378	R:R:L387	R:R:L391	1.38	No	No	0	7	5
379	L:L:L13	R:R:N132	1.37	Yes	No	0	0	3
380	R:R:L103	R:R:N120	1.37	Yes	No	0	7	5
381	R:R:L121	R:R:N126	1.37	Yes	No	0	5	3
382	R:R:K402	R:R:Q405	1.36	No	No	0	4	6
383	R:R:P77	R:R:W76	1.35	No	No	0	4	9
384	R:R:A267	R:R:Y224	1.33	No	Yes	0	3	8
385	R:R:Q400	R:R:Q404	1.28	No	No	0	5	3
386	R:R:F360	R:R:I303	1.26	No	No	0	4	4
387	R:R:M95	R:R:R94	1.24	No	No	0	5	4
388	R:R:K338	R:R:R342	1.24	No	No	0	6	8
389	R:R:F92	R:R:L93	1.22	Yes	No	0	5	5
390	R:R:D56	R:R:R51	1.19	No	Yes	0	3	2
391	L:L:Q20	L:L:R21	1.17	No	No	7	0	0
392	L:L:Q24	L:L:R21	1.17	No	No	7	0	0
393	R:R:L221	R:R:Y224	1.17	No	Yes	0	4	8
394	R:R:H336	R:R:Y337	1.09	Yes	No	0	6	7
395	L:L:R12	R:R:R135	1.07	No	No	0	0	3
396	R:R:F371	R:R:Y138	1.03	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	4.78167	6	1	0
2	L:L:D3	5.12	5	1	0
3	L:L:F6	3.89667	6	1	0
4	L:L:L13	4.725	4	0	0
5	L:L:V27	5.055	4	2	0
6	R:R:L31	4.31	4	0	4
7	R:R:R51	2.2125	4	10	2
8	R:R:E52	4.0875	4	10	3
9	R:R:W70	7.77	5	9	7
10	R:R:I73	4.928	5	2	5
11	R:R:P81	6.3625	4	0	4
12	R:R:C89	4.3325	4	5	9
13	R:R:F92	8.77	4	8	5
14	R:R:L103	3.6325	4	5	7
15	R:R:R105	10.356	5	2	8
16	R:R:G111	2.5575	4	0	9
17	R:R:W112	19.4275	4	2	9
18	R:R:T115	4.0525	4	2	4
19	R:R:F116	12.44	5	2	4
20	R:R:L121	2.6125	4	2	5
21	R:R:L139	3.27	4	1	4
22	R:R:Y146	4.25857	7	1	7
23	R:R:Y150	5.956	5	1	7
24	R:R:F182	3.9175	4	0	8
25	R:R:F185	6.256	5	3	8
26	R:R:N192	6.1125	4	1	8
27	R:R:F222	6.955	6	1	6
28	R:R:Q223	3.8625	4	1	7
29	R:R:Y224	3.6575	4	0	8
30	R:R:I226	6.8725	4	1	6
31	R:R:N229	7.58	4	0	8
32	R:R:W232	10.655	4	6	9
33	R:R:E236	5.475	4	0	9
34	R:R:Y239	5.4875	4	0	8
35	R:R:H241	5.9525	4	0	8
36	R:R:W263	6.5175	4	6	9
37	R:R:P266	4.492	5	13	9
38	R:R:W273	5.462	5	1	8
39	R:R:W286	8.11	5	1	9
40	R:R:W295	5.0725	4	0	6
41	R:R:I298	6.34	4	1	7
42	R:R:V302	3.432	5	0	6
43	R:R:H336	2.7275	4	15	6
44	R:R:L350	8.0825	4	3	8
45	R:R:F351	4.53	6	3	9
46	R:R:H354	5.77	4	0	8
47	R:R:Y355	9.738	5	0	8
48	R:R:F358	5.854	5	4	7
49	R:R:S361	3.272	5	4	5
50	R:R:Q369	4.5025	4	4	7
51	R:R:L374	4.0525	4	0	7
52	R:R:Q380	4.5325	4	3	9
53	R:R:V384	2.985	4	3	9
54	R:R:Y388	7.8525	4	3	8
55	R:R:E398	7.5475	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D3	L:L:H1	66.3337	2.52	Yes	Yes	1	0	0
2	L:L:H1	R:R:Q223	15.4697	2.47	Yes	Yes	1	0	7
3	L:L:D3	R:R:F222	10.5257	8.36	Yes	Yes	1	0	6
4	R:R:F222	R:R:Q223	11.683	5.86	Yes	Yes	1	6	7
5	L:L:H1	R:R:I298	16.7651	2.65	Yes	Yes	1	0	7
6	L:L:H1	R:R:V302	78.1202	2.77	Yes	Yes	0	0	6
7	L:L:D3	L:L:F6	70.096	2.39	Yes	Yes	1	0	0
8	L:L:S2	R:R:L374	10.8384	3	No	Yes	0	0	7
9	L:L:F6	R:R:Y146	31.0755	5.16	Yes	Yes	1	0	7
10	R:R:I226	R:R:Y230	11.7074	2.42	Yes	No	0	6	8
11	R:R:Y230	R:R:Y355	14.8261	19.86	No	Yes	0	8	8
12	L:L:F6	R:R:L139	100	2.44	Yes	Yes	1	0	4
13	L:L:L13	R:R:L139	98.063	1.38	Yes	Yes	0	0	4
14	R:R:F222	R:R:K195	13.6708	7.44	Yes	No	0	6	7
15	L:L:L13	R:R:N132	95.1392	1.37	Yes	No	0	0	3
16	R:R:D129	R:R:N132	94.6377	16.16	No	No	0	2	3
17	R:R:D129	R:R:V127	93.6225	2.92	No	No	0	2	2
18	R:R:N126	R:R:V127	93.1088	5.91	No	No	0	3	2
19	R:R:L121	R:R:N126	92.591	1.37	Yes	No	0	5	3
20	R:R:L121	R:R:T115	86.4713	2.95	Yes	Yes	2	5	4
21	R:R:P117	R:R:T115	84.7759	1.75	No	Yes	2	4	4
22	R:R:F116	R:R:P117	53.7167	2.89	Yes	No	2	4	4
23	R:R:F116	R:R:R118	47.8894	12.83	Yes	No	0	4	6
24	R:R:N120	R:R:R118	46.326	3.62	No	No	0	5	6
25	R:R:L103	R:R:N120	45.5382	1.37	Yes	No	0	7	5
26	R:R:C89	R:R:L103	22.428	4.76	Yes	Yes	5	9	7
27	R:R:C89	R:R:P90	20.7265	3.77	Yes	No	5	9	8
28	R:R:L93	R:R:P90	39.652	11.49	No	No	0	5	8
29	R:R:F92	R:R:L93	27.2441	1.22	Yes	No	0	5	5
30	R:R:F92	R:R:V34	18.2189	7.87	Yes	No	8	5	4
31	R:R:L35	R:R:V34	16.4687	1.49	No	No	0	2	4
32	R:R:L31	R:R:L35	12.8464	4.15	Yes	No	0	4	2
33	R:R:C123	R:R:L103	21.5204	4.76	No	Yes	5	9	7
34	R:R:C123	R:R:P90	20.6696	3.77	No	No	5	9	8
35	R:R:P117	R:R:R105	30.4704	5.76	No	Yes	2	4	8
36	R:R:R105	R:R:W76	25.5873	4	Yes	No	0	8	9
37	R:R:P77	R:R:W76	22.9011	1.35	No	No	0	4	9
38	R:R:E52	R:R:P77	21.9935	3.14	Yes	No	0	3	4
39	R:R:E52	R:R:G68	15.5266	3.27	Yes	No	0	3	4
40	R:R:E67	R:R:G68	13.6424	1.64	No	No	0	4	4
41	R:R:E67	R:R:M69	11.7175	2.71	No	No	11	4	5
42	R:R:L49	R:R:M69	10.7856	4.24	No	No	0	5	5
43	R:R:G111	R:R:W112	14.2596	2.81	Yes	Yes	0	9	9
44	R:R:L93	R:R:L96	11.0109	4.15	No	No	0	5	5
45	R:R:F379	R:R:S378	12.55	3.96	No	No	0	7	9
46	R:R:R188	R:R:Y150	23.8411	7.2	No	Yes	0	8	7
47	R:R:N229	R:R:R188	20.627	7.23	Yes	No	0	8	8
48	R:R:F185	R:R:N229	18.7143	14.5	Yes	Yes	0	8	8
49	R:R:F185	R:R:V384	16.1296	3.93	Yes	Yes	3	8	9
50	R:R:H354	R:R:Y355	16.8788	10.89	Yes	Yes	0	8	8
51	R:R:H354	R:R:Q380	13.415	7.42	Yes	Yes	0	8	9
52	R:R:Q380	R:R:V384	10.7978	2.87	Yes	Yes	3	9	9
53	R:R:S305	R:R:V302	70.693	3.23	No	Yes	0	7	6
54	R:R:L234	R:R:S305	70.1671	3	No	No	0	8	7
55	R:R:I308	R:R:L234	25.4005	2.85	No	No	0	6	8
56	R:R:I308	R:R:L312	23.8736	2.85	No	No	0	6	8
57	R:R:L238	R:R:L312	21.6869	2.77	No	No	0	6	8
58	R:R:L238	R:R:T242	20.9031	2.95	No	No	0	6	7
59	R:R:F258	R:R:T242	20.2981	2.59	No	No	0	7	7
60	R:R:F258	R:R:Y239	16.5926	6.19	No	Yes	0	7	8
61	R:R:T173	R:R:Y239	48.2406	4.99	No	Yes	0	7	8
62	R:R:R252	R:R:T173	46.0904	10.35	No	No	0	4	7
63	R:R:L255	R:R:R252	43.9362	2.43	No	No	0	5	4
64	R:R:L255	R:R:Y176	41.7778	3.52	No	No	0	5	6
65	R:R:H171	R:R:Y176	39.6154	15.24	No	No	0	7	6
66	R:R:H171	R:R:N175	37.449	11.48	No	No	0	7	8
67	R:R:N175	R:R:R174	33.1039	8.44	No	No	0	8	9
68	R:R:N392	R:R:R174	28.7426	7.23	No	No	0	9	9
69	R:R:E394	R:R:N392	19.9712	3.94	No	No	0	9	9
70	R:R:E394	R:R:L170	17.7682	2.65	No	No	0	9	9
71	R:R:E398	R:R:L170	15.5611	6.63	Yes	No	0	8	9
72	R:R:L234	R:R:N309	44.8174	8.24	No	No	0	8	9
73	R:R:F351	R:R:N309	44.3686	2.42	Yes	No	0	9	9
74	R:R:F351	R:R:G237	16.2332	4.52	Yes	No	0	9	8
75	R:R:E236	R:R:G237	15.6525	3.27	Yes	No	0	9	8
76	R:R:E236	R:R:I177	45.2113	2.73	Yes	No	0	9	9
77	R:R:I177	R:R:Y239	43.6478	7.25	No	Yes	0	9	8
78	R:R:F351	R:R:L350	20.3366	2.44	Yes	Yes	3	9	8
79	R:R:E236	R:R:L350	31.445	13.25	Yes	Yes	0	9	8
80	R:R:V384	R:R:Y388	20.2656	2.52	Yes	Yes	3	9	8
81	R:R:Q223	R:R:W273	18.9011	4.38	Yes	Yes	1	7	8
82	R:R:W273	R:R:W286	21.9265	2.81	Yes	Yes	1	8	9
83	R:R:I298	R:R:W273	11.681	10.57	Yes	Yes	1	7	8
84	R:R:M227	R:R:V302	20.0625	3.04	No	Yes	0	6	6
85	R:R:M227	R:R:P266	10.1622	3.35	No	Yes	0	6	9
86	R:R:I306	R:R:V302	11.6444	3.07	No	Yes	0	7	6
87	R:R:F313	R:R:F351	16.0484	4.29	No	Yes	3	9	9
88	R:R:F313	R:R:T344	15.1692	2.59	No	No	0	9	8
89	R:R:L317	R:R:T344	14.2515	4.42	No	No	0	6	8
90	R:R:L317	R:R:M321	13.3297	1.41	No	No	0	6	5
91	R:R:L340	R:R:M321	12.4038	4.24	No	No	0	8	5
92	R:R:E373	R:R:Q369	15.5489	5.1	No	Yes	0	7	7
93	L:L:S2	R:R:E373	10.3226	12.94	No	No	0	0	7
94	R:R:V302	R:R:Y230	10.6049	5.05	Yes	No	0	6	8
95	R:R:L350	R:R:Y388	17.3377	14.07	Yes	Yes	3	8	8
96	R:R:Y146	R:R:Y150	19.3783	3.97	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:Q223	2.47	1	Yes	Yes	0	7	0	1
L:L:H1	R:R:I226	11.93	1	Yes	Yes	0	6	0	1
L:L:H1	R:R:I298	2.65	1	Yes	Yes	0	7	0	1
L:L:H1	R:R:V302	2.77	1	Yes	Yes	0	6	0	1
L:L:S2	R:R:E373	12.94	0	No	No	0	7	0	1
L:L:S2	R:R:L374	3	0	No	Yes	0	7	0	1
L:L:D3	R:R:N192	6.73	1	Yes	Yes	0	8	0	1
L:L:D3	R:R:F222	8.36	1	Yes	Yes	0	6	0	1
L:L:D3	R:R:I226	5.6	1	Yes	Yes	0	6	0	1
L:L:G4	R:R:W295	2.81	0	No	Yes	0	6	0	1
L:L:T5	R:R:W295	2.43	0	No	Yes	0	6	0	1
L:L:F6	R:R:L139	2.44	1	Yes	Yes	0	4	0	1
L:L:F6	R:R:L142	3.65	1	Yes	No	0	6	0	1
L:L:F6	R:R:Y146	5.16	1	Yes	Yes	0	7	0	1
L:L:F6	R:R:L370	6.09	1	Yes	No	0	6	0	1
L:L:S8	R:R:N289	8.94	0	No	No	0	6	0	1
L:L:L10	R:R:L139	6.92	1	No	Yes	0	4	0	1
L:L:L10	R:R:F200	7.31	1	No	No	0	4	0	1
L:L:S11	R:R:D287	2.94	0	No	No	0	6	0	1
L:L:L13	R:R:R135	9.72	0	Yes	No	0	3	0	1
L:L:L13	R:R:H136	6.43	0	Yes	No	0	1	0	1
L:L:E15	R:R:R30	3.49	0	No	No	0	6	0	1
L:L:E15	R:R:L31	5.3	0	No	Yes	0	4	0	1
L:L:R18	R:R:L31	3.64	0	No	Yes	0	4	0	1
L:L:L19	R:R:L31	4.15	0	No	Yes	0	4	0	1
L:L:L26	R:R:I73	2.85	0	No	Yes	0	5	0	1
L:L:V27	R:R:I73	7.68	2	Yes	Yes	0	5	0	1
L:L:V27	R:R:L121	2.98	2	Yes	Yes	0	5	0	1
L:L:V27	R:R:A122	5.09	2	Yes	No	0	5	0	1
R:R:L31	R:R:L35	4.15	0	Yes	No	4	2	1	1
R:R:D71	R:R:I73	5.6	0	No	Yes	9	5	2	1
R:R:E114	R:R:I73	5.47	2	No	Yes	2	5	2	1
R:R:I73	R:R:T115	3.04	2	Yes	Yes	5	4	1	2
R:R:E114	R:R:T115	8.47	2	No	Yes	2	4	2	2
R:R:L121	R:R:T115	2.95	2	Yes	Yes	5	4	1	2
R:R:A122	R:R:L121	3.15	2	No	Yes	5	5	1	1
R:R:D129	R:R:N132	16.16	0	No	No	2	3	2	1
R:R:R135	R:R:S131	9.22	0	No	No	3	2	1	2
R:R:L142	R:R:L374	5.54	0	No	Yes	6	7	1	1
R:R:K143	R:R:Y146	2.39	0	No	Yes	5	7	2	1
R:R:T147	R:R:Y146	8.74	0	No	Yes	6	7	2	1
R:R:Y146	R:R:Y150	3.97	1	Yes	Yes	7	7	1	2
R:R:N192	R:R:Y146	3.49	1	Yes	Yes	8	7	1	1
R:R:L374	R:R:Y146	3.52	0	Yes	Yes	7	7	1	1
R:R:S378	R:R:Y146	2.54	1	No	Yes	9	7	2	1
R:R:N192	R:R:Y150	6.98	1	Yes	Yes	8	7	1	2
R:R:S378	R:R:Y150	7.63	1	No	Yes	9	7	2	2
R:R:F222	R:R:S191	5.28	1	Yes	No	6	5	1	2
R:R:F222	R:R:N192	7.25	1	Yes	Yes	6	8	1	1
R:R:F222	R:R:K195	7.44	1	Yes	No	6	7	1	2
R:R:F200	R:R:L199	8.53	0	No	No	4	6	1	2
R:R:F222	R:R:Q223	5.86	1	Yes	Yes	6	7	1	1
R:R:F222	R:R:I226	7.54	1	Yes	Yes	6	6	1	1
R:R:Q223	R:R:W273	4.38	1	Yes	Yes	7	8	1	2
R:R:I298	R:R:Q223	2.74	1	Yes	Yes	7	7	1	1
R:R:I226	R:R:Y230	2.42	1	Yes	No	6	8	1	2
R:R:M227	R:R:V302	3.04	0	No	Yes	6	6	2	1
R:R:V302	R:R:Y230	5.05	0	Yes	No	6	8	1	2
R:R:Y230	R:R:Y355	19.86	0	No	Yes	8	8	2	2
R:R:I298	R:R:W273	10.57	1	Yes	Yes	7	8	1	2
R:R:N289	R:R:W295	5.65	0	No	Yes	6	6	1	1
R:R:I298	R:R:W295	9.4	1	Yes	Yes	7	6	1	1
R:R:S305	R:R:V302	3.23	0	No	Yes	7	6	2	1
R:R:I306	R:R:V302	3.07	0	No	Yes	7	6	2	1
R:R:I306	R:R:Y355	3.63	0	No	Yes	7	8	2	2
R:R:E373	R:R:Y355	11.22	0	No	Yes	7	8	1	2
R:R:E373	R:R:Q369	5.1	0	No	Yes	7	7	1	2
R:R:L370	R:R:L374	4.15	0	No	Yes	6	7	1	1
R:R:L139	R:R:Y138	2.34	1	Yes	No	4	4	1	2
R:R:C285	R:R:D287	1.56	12	No	No	9	6	2	1
R:R:L35	R:R:V34	1.49	0	No	No	2	4	1	2
L:L:L13	R:R:L139	1.38	0	Yes	Yes	0	4	0	1
L:L:L22	R:R:L35	1.38	0	No	No	0	2	0	1
L:L:L13	R:R:N132	1.37	0	Yes	No	0	3	0	1
R:R:L121	R:R:N126	1.37	2	Yes	No	5	3	1	2
L:L:R12	R:R:R135	1.07	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6WI9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.39
Number of Linked Nodes	355
Number of Links	396
Number of Hubs	55
Number of Links mediated by Hubs	195
Number of Communities	15
Number of Nodes involved in Communities	78
Number of Links involved in Communities	100

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	104493
Length Of Smallest Path	3
Average Path Length	18.8576
Length of Longest Path	48
Minimum Path Strength	1.25
Average Path Strength	5.01052
Maximum Path Strength	24.925
Minimum Path Correlation	0.7
Average Path Correlation	0.965202
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	60.8546
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.5783
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • G protein-coupled receptor binding • digestive hormone activity • head development • central nervous system development • brain development • nervous system development • response to nutrient levels • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • energy homeostasis • forebrain development • pallium development • telencephalon development • hippocampus development • limbic system development • regulation of localization • transport • digestive system process • regulation of system process • negative regulation of biological process • negative regulation of gastrin-induced gastric acid secretion • negative regulation of transport • localization • negative regulation of secretion • gastrin-induced gastric acid secretion • regulation of gastrin-induced gastric acid secretion • regulation of multicellular organismal process • negative regulation of digestive system process • regulation of gastric acid secretion • secretion • regulation of transport • acid secretion • regulation of digestive system process • gastric acid secretion • establishment of localization • regulation of secretion • digestion • negative regulation of multicellular organismal process • negative regulation of gastric acid secretion • regulation of body fluid levels • secretion by tissue • pancreatic juice secretion • body fluid secretion • regulation of biological quality • positive regulation of biological process • positive regulation of secretion • positive regulation of digestive system process • positive regulation of pancreatic juice secretion • regulation of pancreatic juice secretion • positive regulation of transport • positive regulation of multicellular organismal process • regulation of synaptic plasticity • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • regulation of appetite • digestive system development • tube development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • cAMP/PKA signal transduction • regulation of intracellular signal transduction • positive regulation of cellular process • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • regulation of response to stimulus • positive regulation of signaling • lipid catabolic process • catabolic process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • positive regulation of catabolic process • positive regulation of metabolic process • positive regulation of lipid catabolic process • positive regulation of lipid metabolic process • regulation of metabolic process • lipid metabolic process • nitrogen compound transport • regulation of hormone secretion • regulation of peptide secretion • positive regulation of secretion by cell • positive regulation of somatostatin secretion • hormone secretion • somatostatin secretion • peptide secretion • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • amide transport • signal release • regulation of peptide hormone secretion • positive regulation of peptide secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • regulation of peptide transport • export from cell • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cellular component size • cell volume homeostasis • cellular component organization • cellular homeostasis • intracellular water homeostasis • chemical homeostasis • intracellular chemical homeostasis • cellular component organization or biogenesis • regulation of cell size • regulation of anatomical structure size • amide binding • peptide hormone binding • hormone binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • secretin receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • cell surface receptor signaling pathway • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • polymeric cytoskeletal fiber • intracellular membraneless organelle • cytoplasmic microtubule • cytoskeleton • membraneless organelle • supramolecular fiber • microtubule • supramolecular polymer • supramolecular complex • microtubule cytoskeleton
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47872
Sequence	>6WI9_nogp_Chain_R R L C D V L Q V L W E E Q D Q C L Q E L S R E Q T G D L G T E Q P V P G C E G M W D N I S C W P S S V P G R M V E V E C P R F L R M L T S R N G S L F R N C T Q D G W S E T F P R P N L A C G V N V N D S S N E K R H S Y L L K L K V M Y T V G Y S S S L V M L L V A L G I L C A F R R L H C T R N Y I H M H L F V S F I L R A L S N F I K D A V L F R A G C K L V M V L F Q Y C I M A N Y S W L L V E G L Y L H T L L A I S F F S E R K Y L Q G F V A F G W G S P A I F V A L W A I A R H F L E D V G C W D I N A N A S I W W I I R G P V I L S I L I N F I L F I N I L R I L M R K L R T Q E T R G N E V S H Y K R L A R S T L L L I P L F G I H Y I V F A F S P E D A M E I Q L F F E L A L G S F Q G L V V A V L Y C F L N G E V Q L E V Q K K W Q Q W H L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	10.1038/s41467-020-17791-4
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	10.1038/s41467-020-17791-4

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