psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
2	L:L:H1	R:R:Q223	6.18	Yes	Yes	1	0	7
3	L:L:H1	R:R:I226	18.56	Yes	Yes	1	0	6
4	L:L:H1	R:R:Y230	4.36	Yes	Yes	1	0	8
5	L:L:H1	R:R:W295	5.29	Yes	Yes	1	0	6
6	L:L:S2	R:R:Q369	5.78	No	No	1	0	7
7	L:L:S2	R:R:E373	10.06	No	No	1	0	7
8	L:L:D3	R:R:Y150	5.75	Yes	Yes	1	0	7
9	L:L:D3	R:R:R188	8.34	Yes	Yes	1	0	8
10	L:L:D3	R:R:N192	9.42	Yes	Yes	1	0	8
11	L:L:D3	R:R:F222	3.58	Yes	Yes	1	0	6
12	L:L:D3	R:R:I226	5.6	Yes	Yes	1	0	6
13	L:L:D3	R:R:L374	12.21	Yes	Yes	1	0	7
14	L:L:G4	L:L:T7	3.64	No	No	0	0	0
15	L:L:T5	R:R:M366	4.52	No	Yes	0	0	5
16	L:L:F6	L:L:L10	3.65	Yes	Yes	1	0	0
17	L:L:F6	R:R:L139	4.87	Yes	No	1	0	4
18	L:L:F6	R:R:K143	7.44	Yes	Yes	1	0	5
19	L:L:F6	R:R:Y146	13.41	Yes	Yes	1	0	7
20	L:L:F6	R:R:L370	3.65	Yes	No	0	0	6
21	L:L:F6	R:R:L374	3.65	Yes	Yes	1	0	7
22	L:L:T7	R:R:K195	9.01	No	Yes	0	0	7
23	L:L:T7	R:R:F200	3.89	No	Yes	0	0	4
24	L:L:S8	R:R:N289	7.45	No	No	0	0	6
25	L:L:E9	L:L:R12	10.47	No	No	0	0	0
26	L:L:E9	R:R:R135	5.82	No	Yes	8	0	3
27	L:L:E9	R:R:M366	9.47	No	Yes	8	0	5
28	L:L:L10	L:L:R14	3.64	Yes	Yes	1	0	0
29	L:L:L10	R:R:L139	5.54	Yes	No	1	0	4
30	L:L:L10	R:R:K143	4.23	Yes	Yes	1	0	5
31	L:L:L10	R:R:F200	9.74	Yes	Yes	1	0	4
32	L:L:S11	R:R:F200	3.96	No	Yes	0	0	4
33	L:L:S11	R:R:D287	8.83	No	Yes	0	0	6
34	L:L:L13	L:L:R12	8.5	Yes	No	0	0	0
35	L:L:L13	R:R:R135	3.64	Yes	Yes	0	0	3
36	L:L:L13	R:R:H136	7.71	Yes	No	0	0	1
37	L:L:R14	L:L:R18	8.53	Yes	No	0	0	0
38	L:L:R14	R:R:H136	3.39	Yes	No	0	0	1
39	L:L:R14	R:R:F200	6.41	Yes	Yes	1	0	4
40	L:L:E15	L:L:G16	3.27	No	No	0	0	0
41	L:L:R18	L:L:R21	6.4	No	No	0	0	0
42	L:L:R18	R:R:V205	7.85	No	No	0	0	4
43	L:L:Q20	R:R:V125	5.73	No	No	0	0	3
44	L:L:Q20	R:R:D129	3.92	No	No	0	0	2
45	L:L:R21	R:R:D203	5.96	No	No	0	0	4
46	L:L:L22	L:L:L26	5.54	No	No	0	0	0
47	L:L:L22	R:R:L31	4.15	No	Yes	0	0	4
48	L:L:L23	R:R:V125	14.9	No	No	0	0	3
49	L:L:V27	R:R:P117	7.07	No	No	0	0	4
50	R:R:D33	R:R:R30	16.68	Yes	Yes	0	6	6
51	R:R:R30	R:R:V283	3.92	Yes	No	0	6	3
52	R:R:D33	R:R:V34	4.38	Yes	No	9	6	4
53	R:R:D33	R:R:F92	22.69	Yes	No	9	6	5
54	R:R:P90	R:R:V34	3.53	Yes	No	0	8	4
55	R:R:F92	R:R:V34	3.93	No	No	9	5	4
56	R:R:R91	R:R:V37	3.92	No	No	0	2	5
57	R:R:L38	R:R:Q42	10.65	No	Yes	0	6	5
58	R:R:D43	R:R:W39	7.82	No	No	0	3	3
59	R:R:E41	R:R:Q44	5.1	No	No	0	6	4
60	R:R:C75	R:R:E41	10.64	No	No	0	9	6
61	R:R:E41	R:R:V87	7.13	No	No	0	6	5
62	R:R:Q42	R:R:W70	13.14	Yes	Yes	10	5	7
63	R:R:D71	R:R:Q42	6.53	No	Yes	10	9	5
64	R:R:Q44	R:R:Q47	3.84	No	No	0	4	3
65	R:R:C45	R:R:W70	3.92	No	Yes	0	9	7
66	R:R:C45	R:R:C75	7.28	No	No	0	9	9
67	R:R:L46	R:R:L49	4.15	No	No	0	3	5
68	R:R:E48	R:R:R51	9.3	No	No	2	3	2
69	R:R:E48	R:R:S78	5.75	No	No	2	3	4
70	R:R:R51	R:R:S78	10.54	No	No	2	2	4
71	R:R:G65	R:R:Q53	3.29	No	No	0	3	2
72	R:R:D110	R:R:E60	10.39	No	No	0	5	1
73	R:R:Q61	R:R:V80	4.3	Yes	No	0	2	1
74	R:R:P62	R:R:W112	6.76	No	No	0	2	9
75	R:R:P64	R:R:V63	3.53	Yes	Yes	0	1	1
76	R:R:V63	R:R:W76	4.9	Yes	Yes	2	1	9
77	R:R:G82	R:R:V63	3.68	No	Yes	2	6	1
78	R:R:F104	R:R:V63	11.8	Yes	Yes	2	5	1
79	R:R:N106	R:R:V63	5.91	No	Yes	2	3	1
80	R:R:C66	R:R:P64	5.65	No	Yes	0	9	1
81	R:R:P64	R:R:T108	5.25	Yes	No	0	1	5
82	R:R:C107	R:R:C66	7.28	No	No	0	9	9
83	R:R:E67	R:R:M69	5.41	Yes	No	2	4	5
84	R:R:E67	R:R:I73	6.83	Yes	No	2	4	5
85	R:R:E67	R:R:W76	40.34	Yes	Yes	2	4	9
86	R:R:E67	R:R:R105	16.28	Yes	Yes	2	4	8
87	R:R:M69	R:R:N72	11.22	No	No	2	5	4
88	R:R:M69	R:R:R105	4.96	No	Yes	2	5	8
89	R:R:D71	R:R:W70	15.63	No	Yes	10	9	7
90	R:R:N72	R:R:R105	3.62	No	Yes	2	4	8
91	R:R:I73	R:R:W76	3.52	No	Yes	2	5	9
92	R:R:I73	R:R:V85	6.14	No	Yes	2	5	7
93	R:R:S74	R:R:V87	4.85	No	No	0	5	5
94	R:R:P90	R:R:S74	3.56	Yes	No	0	8	5
95	R:R:P77	R:R:W76	13.51	No	Yes	2	4	9
96	R:R:S78	R:R:W76	8.65	No	Yes	2	4	9
97	R:R:V85	R:R:W76	4.9	Yes	Yes	2	7	9
98	R:R:F104	R:R:W76	6.01	Yes	Yes	2	5	9
99	R:R:P77	R:R:V85	10.6	No	Yes	2	4	7
100	R:R:P81	R:R:V80	5.3	No	No	0	4	1
101	R:R:F104	R:R:G82	6.02	Yes	No	2	5	6
102	R:R:E88	R:R:G101	4.91	No	No	0	3	5
103	R:R:E88	R:R:L103	9.28	No	Yes	2	3	7
104	R:R:E88	R:R:N120	6.57	No	No	2	3	5
105	R:R:C89	R:R:P90	3.77	No	Yes	0	9	8
106	R:R:C89	R:R:T97	6.76	No	No	11	9	5
107	R:R:C123	R:R:C89	5.46	No	No	11	9	9
108	R:R:L93	R:R:P90	4.93	No	Yes	0	5	8
109	R:R:L93	R:R:L96	4.15	No	No	0	5	5
110	R:R:M95	R:R:R94	7.44	No	No	0	5	4
111	R:R:C123	R:R:T97	3.38	No	No	11	9	5
112	R:R:L121	R:R:R99	7.29	No	No	0	5	3
113	R:R:G101	R:R:N100	3.39	No	No	0	5	3
114	R:R:G101	R:R:S102	3.71	No	No	0	5	3
115	R:R:L103	R:R:T115	8.84	Yes	No	0	7	4
116	R:R:L103	R:R:N120	13.73	Yes	No	2	7	5
117	R:R:F104	R:R:N106	8.46	Yes	No	2	5	3
118	R:R:F104	R:R:W112	12.03	Yes	No	0	5	9
119	R:R:E114	R:R:R105	13.96	No	Yes	0	2	8
120	R:R:N106	R:R:T108	13.16	No	No	0	3	5
121	R:R:G111	R:R:T108	5.46	No	No	0	9	5
122	R:R:D110	R:R:G111	5.03	No	No	0	5	9
123	R:R:F116	R:R:P117	4.33	No	No	0	4	4
124	R:R:P119	R:R:R118	4.32	No	No	0	8	6
125	R:R:L121	R:R:N120	10.98	No	No	0	5	5
126	R:R:N132	R:R:S131	4.47	No	No	0	3	2
127	R:R:E133	R:R:K134	5.4	No	No	0	2	1
128	R:R:M366	R:R:R135	7.44	Yes	Yes	8	5	3
129	R:R:E367	R:R:R135	12.79	No	Yes	0	2	3
130	R:R:K141	R:R:S137	6.12	No	No	0	4	1
131	R:R:L142	R:R:Y138	14.07	No	No	0	6	4
132	R:R:E367	R:R:Y138	19.08	No	No	0	2	4
133	R:R:F371	R:R:Y138	4.13	No	No	0	6	4
134	R:R:K143	R:R:Y146	8.36	Yes	Yes	1	5	7
135	R:R:D196	R:R:K143	8.3	Yes	Yes	1	7	5
136	R:R:F200	R:R:K143	4.96	Yes	Yes	1	4	5
137	R:R:A375	R:R:M145	3.22	No	No	0	6	6
138	R:R:Y146	R:R:Y150	7.94	Yes	Yes	1	7	7
139	R:R:N192	R:R:Y146	5.81	Yes	Yes	1	8	7
140	R:R:K195	R:R:Y146	3.58	Yes	Yes	1	7	7
141	R:R:D196	R:R:Y146	8.05	Yes	Yes	1	7	7
142	R:R:L374	R:R:Y146	9.38	Yes	Yes	1	7	7
143	R:R:G149	R:R:S378	3.71	No	No	0	8	9
144	R:R:F379	R:R:G149	9.03	No	No	0	7	8
145	R:R:R188	R:R:Y150	10.29	Yes	Yes	1	8	7
146	R:R:A189	R:R:Y150	4	No	Yes	0	8	7
147	R:R:N192	R:R:Y150	13.96	Yes	Yes	1	8	7
148	R:R:L374	R:R:Y150	3.52	Yes	Yes	1	7	7
149	R:R:S378	R:R:Y150	7.63	No	Yes	0	9	7
150	R:R:F193	R:R:S151	5.28	No	No	0	8	6
151	R:R:G381	R:R:S153	3.71	No	No	0	9	9
152	R:R:L154	R:R:L158	4.15	No	No	0	6	4
153	R:R:I186	R:R:L154	4.28	No	No	0	7	6
154	R:R:L382	R:R:M156	4.24	No	No	0	5	6
155	R:R:F182	R:R:L157	6.09	No	Yes	0	8	9
156	R:R:G381	R:R:L157	3.42	No	Yes	0	9	9
157	R:R:A160	R:R:C389	3.61	No	Yes	0	9	8
158	R:R:C389	R:R:I163	4.91	Yes	No	0	8	8
159	R:R:L164	R:R:N175	8.24	No	Yes	0	8	8
160	R:R:F182	R:R:L164	3.65	No	No	0	8	8
161	R:R:C165	R:R:M179	3.24	No	No	0	2	6
162	R:R:F167	R:R:L170	7.31	No	No	0	7	9
163	R:R:E398	R:R:F167	13.99	No	No	0	8	7
164	R:R:L397	R:R:R169	3.64	No	No	0	4	7
165	R:R:E398	R:R:R169	23.26	No	No	0	8	7
166	R:R:L170	R:R:V395	4.47	No	No	0	9	9
167	R:R:H171	R:R:Y176	10.89	No	No	0	7	6
168	R:R:C172	R:R:R174	5.57	No	Yes	3	8	9
169	R:R:C172	R:R:N175	6.3	No	Yes	3	8	8
170	R:R:T173	R:R:Y239	7.49	No	No	5	7	8
171	R:R:R252	R:R:T173	10.35	Yes	No	5	4	7
172	R:R:L255	R:R:T173	7.37	No	No	0	5	7
173	R:R:N175	R:R:R174	3.62	Yes	Yes	3	8	9
174	R:R:H178	R:R:R174	5.64	Yes	Yes	3	9	9
175	R:R:E394	R:R:R174	3.49	No	Yes	0	9	9
176	R:R:H178	R:R:N175	3.83	Yes	Yes	3	9	8
177	R:R:M179	R:R:Y176	4.79	No	No	0	6	6
178	R:R:E236	R:R:I177	6.83	Yes	No	0	9	9
179	R:R:E236	R:R:H178	11.08	Yes	Yes	3	9	9
180	R:R:H178	R:R:L350	3.86	Yes	Yes	3	9	8
181	R:R:H178	R:R:Y388	7.62	Yes	No	3	9	8
182	R:R:H180	R:R:W232	15.87	No	Yes	6	8	9
183	R:R:H180	R:R:V259	6.92	No	No	6	8	5
184	R:R:H180	R:R:W263	7.41	No	No	6	8	9
185	R:R:F185	R:R:L181	6.09	Yes	No	0	8	9
186	R:R:E236	R:R:L181	11.93	Yes	No	0	9	9
187	R:R:N229	R:R:S184	7.45	No	No	0	8	9
188	R:R:S184	R:R:W232	7.41	No	Yes	0	9	9
189	R:R:F185	R:R:N229	18.12	Yes	No	0	8	8
190	R:R:F185	R:R:Q380	9.37	Yes	Yes	0	8	9
191	R:R:F185	R:R:G381	9.03	Yes	No	0	8	9
192	R:R:F185	R:R:V384	3.93	Yes	No	0	8	9
193	R:R:I226	R:R:R188	10.02	Yes	Yes	1	6	8
194	R:R:N229	R:R:R188	10.85	No	Yes	0	8	8
195	R:R:R188	R:R:Y230	11.32	Yes	Yes	1	8	8
196	R:R:R188	R:R:Y355	7.2	Yes	Yes	1	8	8
197	R:R:C225	R:R:S191	5.16	No	No	0	6	5
198	R:R:K195	R:R:N192	4.2	Yes	Yes	1	7	8
199	R:R:F222	R:R:N192	7.25	Yes	Yes	1	6	8
200	R:R:D196	R:R:K195	4.15	Yes	Yes	1	7	7
201	R:R:F222	R:R:K195	21.09	Yes	Yes	1	6	7
202	R:R:D196	R:R:F200	4.78	Yes	Yes	1	7	4
203	R:R:V198	R:R:Y207	7.57	No	Yes	12	4	4
204	R:R:C215	R:R:V198	3.42	No	No	12	9	4
205	R:R:V198	R:R:V218	4.81	No	No	0	4	6
206	R:R:F200	R:R:L199	8.53	Yes	No	0	4	6
207	R:R:D287	R:R:L199	4.07	Yes	No	0	6	6
208	R:R:S201	R:R:T206	3.2	No	No	0	4	3
209	R:R:D203	R:R:S202	4.42	No	No	0	4	3
210	R:R:C208	R:R:V205	6.83	No	No	0	4	4
211	R:R:T206	R:R:Y207	7.49	No	Yes	0	3	4
212	R:R:H211	R:R:Y207	5.44	No	Yes	0	7	4
213	R:R:C215	R:R:Y207	5.38	No	Yes	12	9	4
214	R:R:D209	R:R:R212	3.57	No	No	0	4	3
215	R:R:G284	R:R:R212	7.51	No	No	0	4	3
216	R:R:C215	R:R:C285	7.28	No	No	0	9	9
217	R:R:D282	R:R:K216	5.53	No	No	1	6	8
218	R:R:K216	R:R:W286	27.85	No	Yes	1	8	9
219	R:R:F222	R:R:Q223	8.2	Yes	Yes	1	6	7
220	R:R:F222	R:R:I226	8.79	Yes	Yes	1	6	6
221	R:R:Q223	R:R:W273	8.76	Yes	Yes	1	7	8
222	R:R:Q223	R:R:W295	6.57	Yes	Yes	1	7	6
223	R:R:W263	R:R:Y224	5.79	No	Yes	0	9	8
224	R:R:P266	R:R:Y224	5.56	Yes	Yes	0	9	8
225	R:R:M227	R:R:P266	3.35	Yes	Yes	0	6	9
226	R:R:F269	R:R:M227	4.98	No	Yes	0	6	6
227	R:R:I298	R:R:M227	5.83	Yes	Yes	0	7	6
228	R:R:M227	R:R:V302	4.56	Yes	No	0	6	6
229	R:R:V302	R:R:Y230	12.62	No	Yes	0	6	8
230	R:R:I306	R:R:Y230	3.63	No	Yes	1	7	8
231	R:R:Y230	R:R:Y355	19.86	Yes	Yes	1	8	8
232	R:R:F261	R:R:S231	3.96	No	Yes	7	5	5
233	R:R:G262	R:R:S231	3.71	No	Yes	0	8	5
234	R:R:S231	R:R:S265	3.26	Yes	No	7	5	4
235	R:R:P266	R:R:S231	5.34	Yes	Yes	7	9	5
236	R:R:V235	R:R:W232	6.13	No	Yes	0	8	9
237	R:R:V259	R:R:W232	6.13	No	Yes	6	5	9
238	R:R:G262	R:R:W232	8.44	No	Yes	0	8	9
239	R:R:W232	R:R:W263	25.3	Yes	No	6	9	9
240	R:R:L233	R:R:Q380	3.99	No	Yes	0	9	9
241	R:R:L234	R:R:L238	6.92	Yes	No	0	8	6
242	R:R:F261	R:R:L234	3.65	No	Yes	0	5	8
243	R:R:I308	R:R:L234	4.28	No	Yes	0	6	8
244	R:R:L234	R:R:N309	4.12	Yes	No	0	8	9
245	R:R:F258	R:R:V235	3.93	No	No	0	7	8
246	R:R:E236	R:R:L350	13.25	Yes	Yes	3	9	8
247	R:R:G237	R:R:N309	3.39	No	No	3	8	9
248	R:R:F351	R:R:G237	6.02	Yes	No	3	9	8
249	R:R:F258	R:R:L238	4.87	No	No	0	7	6
250	R:R:L243	R:R:Y239	14.07	No	No	5	8	8
251	R:R:R252	R:R:Y239	12.35	Yes	No	5	4	8
252	R:R:L240	R:R:L244	4.15	No	No	13	9	8
253	R:R:I316	R:R:L240	5.71	No	No	13	8	9
254	R:R:A245	R:R:H241	4.39	No	Yes	0	6	8
255	R:R:H241	R:R:L312	12.86	Yes	No	0	8	8
256	R:R:H241	R:R:N315	8.93	Yes	No	0	8	7
257	R:R:H241	R:R:I316	3.98	Yes	No	0	8	8
258	R:R:I246	R:R:T242	6.08	No	No	4	4	7
259	R:R:F249	R:R:T242	15.56	Yes	No	4	6	7
260	R:R:F258	R:R:T242	3.89	No	No	0	7	7
261	R:R:L243	R:R:R252	3.64	No	Yes	5	8	4
262	R:R:I316	R:R:L244	4.28	No	No	13	8	8
263	R:R:F249	R:R:I246	11.3	Yes	No	4	6	4
264	R:R:E251	R:R:F249	4.66	No	Yes	4	6	6
265	R:R:F249	R:R:Y254	7.22	Yes	No	4	6	4
266	R:R:R252	R:R:S250	5.27	Yes	No	0	4	6
267	R:R:E251	R:R:Y254	11.22	No	No	4	6	4
268	R:R:K253	R:R:Y254	10.75	No	No	0	6	4
269	R:R:F261	R:R:S265	13.21	No	No	7	5	4
270	R:R:P266	R:R:S265	3.56	Yes	No	7	9	4
271	R:R:F269	R:R:P301	18.78	No	No	0	6	9
272	R:R:R277	R:R:W273	12	Yes	Yes	1	7	8
273	R:R:W273	R:R:W286	3.75	Yes	Yes	1	8	9
274	R:R:I298	R:R:W273	8.22	Yes	Yes	0	7	8
275	R:R:F279	R:R:I275	3.77	No	No	0	3	4
276	R:R:A276	R:R:I294	4.87	No	Yes	0	4	4
277	R:R:E281	R:R:R277	12.79	No	Yes	0	5	7
278	R:R:R277	R:R:W286	20.99	Yes	Yes	1	7	9
279	R:R:I294	R:R:R277	3.76	Yes	Yes	0	4	7
280	R:R:F279	R:R:H278	3.39	No	No	0	3	2
281	R:R:D282	R:R:H278	7.56	No	No	1	6	2
282	R:R:H278	R:R:W286	4.23	No	Yes	1	2	9
283	R:R:E281	R:R:V283	5.7	No	No	0	5	3
284	R:R:A290	R:R:E281	4.53	No	No	0	4	5
285	R:R:D282	R:R:W286	6.7	No	Yes	1	6	9
286	R:R:C285	R:R:D287	4.67	No	Yes	0	9	6
287	R:R:D287	R:R:I288	5.6	Yes	No	0	6	5
288	R:R:N289	R:R:W295	27.12	No	Yes	0	6	6
289	R:R:N291	R:R:S293	5.96	No	No	0	5	1
290	R:R:I294	R:R:N291	12.74	Yes	No	0	4	5
291	R:R:I298	R:R:W295	7.05	Yes	Yes	0	7	6
292	R:R:R299	R:R:W295	6	Yes	Yes	0	6	6
293	R:R:R299	R:R:W296	14.99	Yes	No	0	6	7
294	R:R:E363	R:R:R299	4.65	No	Yes	0	5	6
295	R:R:G300	R:R:P301	4.06	No	No	0	4	9
296	R:R:I308	R:R:L304	5.71	No	No	0	6	3
297	R:R:I306	R:R:Y355	6.04	No	Yes	1	7	8
298	R:R:F351	R:R:N309	9.67	Yes	No	3	9	9
299	R:R:F310	R:R:I314	6.28	No	No	0	7	4
300	R:R:F310	R:R:I356	11.3	No	No	0	7	5
301	R:R:F313	R:R:I314	3.77	Yes	No	0	9	4
302	R:R:F313	R:R:L317	7.31	Yes	No	3	9	6
303	R:R:F313	R:R:T344	3.89	Yes	No	3	9	8
304	R:R:F313	R:R:L347	4.87	Yes	No	3	9	9
305	R:R:F313	R:R:I348	3.77	Yes	Yes	3	9	7
306	R:R:F313	R:R:F351	5.36	Yes	Yes	3	9	9
307	R:R:F313	R:R:I353	16.33	Yes	No	3	9	5
308	R:R:N315	R:R:R318	6.03	No	No	0	7	7
309	R:R:L317	R:R:T344	8.84	No	No	3	6	8
310	R:R:R318	R:R:R322	4.26	No	No	0	7	7
311	R:R:I319	R:R:R322	3.76	No	No	0	7	7
312	R:R:L320	R:R:L324	6.92	No	No	0	8	7
313	R:R:L324	R:R:M321	4.24	No	Yes	0	7	5
314	R:R:M321	R:R:R325	8.69	Yes	No	0	5	6
315	R:R:L340	R:R:M321	9.9	No	Yes	0	8	5
316	R:R:L324	R:R:R339	6.07	No	No	0	7	8
317	R:R:E328	R:R:G331	3.27	Yes	No	14	7	4
318	R:R:E328	R:R:S335	8.62	Yes	No	0	7	6
319	R:R:E328	R:R:H336	12.31	Yes	No	14	7	6
320	R:R:R330	R:R:T329	10.35	No	No	0	4	4
321	R:R:G331	R:R:H336	3.18	No	No	14	4	6
322	R:R:N332	R:R:V334	10.35	No	No	0	6	5
323	R:R:N332	R:R:S335	4.47	No	No	0	6	6
324	R:R:K338	R:R:V334	4.55	No	No	0	6	5
325	R:R:R339	R:R:R342	8.53	No	No	0	8	8
326	R:R:L346	R:R:R342	7.29	No	No	0	8	8
327	R:R:F351	R:R:L347	7.31	Yes	No	3	9	9
328	R:R:I348	R:R:P349	3.39	Yes	No	0	7	8
329	R:R:I348	R:R:I353	5.89	Yes	No	3	7	5
330	R:R:P349	R:R:V383	5.3	No	No	0	8	6
331	R:R:F351	R:R:L350	7.31	Yes	Yes	3	9	8
332	R:R:L350	R:R:Y388	16.41	Yes	No	3	8	8
333	R:R:G352	R:R:H354	3.18	No	Yes	0	9	8
334	R:R:H354	R:R:Y355	15.24	Yes	Yes	1	8	8
335	R:R:F372	R:R:H354	4.53	No	Yes	1	5	8
336	R:R:H354	R:R:Q380	12.36	Yes	Yes	1	8	9
337	R:R:E373	R:R:Y355	8.98	No	Yes	1	7	8
338	R:R:Q380	R:R:Y355	3.38	Yes	Yes	1	9	8
339	R:R:F358	R:R:V357	7.87	Yes	No	1	7	5
340	R:R:F372	R:R:V357	3.93	No	No	1	5	5
341	R:R:F358	R:R:S361	5.28	Yes	No	0	7	5
342	R:R:F358	R:R:I368	11.3	Yes	No	0	7	4
343	R:R:F358	R:R:Q369	8.2	Yes	No	1	7	7
344	R:R:F358	R:R:F372	9.65	Yes	No	1	7	5
345	R:R:P362	R:R:S361	3.56	No	No	0	6	5
346	R:R:D364	R:R:P362	9.66	No	No	0	5	6
347	R:R:L370	R:R:M366	4.24	No	Yes	0	6	5
348	R:R:E373	R:R:Q369	12.74	No	No	1	7	7
349	R:R:A375	R:R:F371	4.16	No	No	0	6	6
350	R:R:F371	R:R:L376	8.53	No	No	0	6	6
351	R:R:F390	R:R:V386	5.24	No	No	0	8	5
352	R:R:C389	R:R:F390	4.19	Yes	No	0	8	8
353	R:R:C389	R:R:V395	3.42	Yes	No	0	8	9
354	R:R:E394	R:R:N392	5.26	No	No	0	9	9
355	R:R:N392	R:R:V395	5.91	No	No	0	9	9
356	R:R:G393	R:R:Q396	3.29	No	No	0	4	7
357	R:R:Q400	R:R:Q404	6.4	No	No	0	5	3
358	R:R:W403	R:R:W406	4.69	No	No	0	4	4
359	R:R:H407	R:R:W403	12.7	No	No	0	4	4
360	R:R:C66	R:R:L57	3.17	No	No	0	9	3
361	R:R:C165	R:R:L161	3.17	No	No	0	2	6
362	R:R:C225	R:R:L187	3.17	No	No	0	6	6
363	R:R:C225	R:R:L221	3.17	No	No	0	6	4
364	R:R:P64	R:R:Q61	3.16	Yes	Yes	0	1	2
365	R:R:A385	R:R:L157	3.15	No	Yes	0	8	9
366	R:R:I163	R:R:V399	3.07	No	No	0	8	4
367	R:R:I194	R:R:V218	3.07	No	No	0	5	6
368	R:R:I298	R:R:V270	3.07	Yes	No	0	7	7
369	R:R:L382	R:R:S152	3	No	No	0	5	5
370	R:R:L382	R:R:S153	3	No	No	0	5	9
371	R:R:L234	R:R:S305	3	Yes	No	0	8	7
372	R:R:L320	R:R:S343	3	No	No	0	8	9
373	R:R:L161	R:R:V183	2.98	No	No	0	6	4
374	R:R:L187	R:R:V183	2.98	No	No	0	6	4
375	R:R:N192	R:R:S191	2.98	Yes	No	0	8	5
376	R:R:L255	R:R:V259	2.98	No	No	0	5	5
377	R:R:L387	R:R:V383	2.98	No	No	0	7	6
378	R:R:L391	R:R:V386	2.98	No	No	0	5	5
379	R:R:A210	R:R:H211	2.93	No	No	0	3	7
380	R:R:F116	R:R:P119	2.89	No	No	0	4	8
381	R:R:P81	R:R:R83	2.88	No	No	0	4	5
382	R:R:I186	R:R:L157	2.85	No	Yes	0	7	9
383	R:R:I186	R:R:L190	2.85	No	No	0	7	4
384	R:R:I311	R:R:L307	2.85	No	No	0	3	3
385	R:R:I308	R:R:L312	2.85	No	No	0	6	8
386	R:R:L199	R:R:M219	2.83	No	No	0	6	6
387	R:R:K143	R:R:L140	2.82	Yes	No	0	5	3
388	R:R:C32	R:R:R30	2.79	No	Yes	0	6	6
389	L:L:L19	R:R:L31	2.77	No	Yes	0	0	4
390	L:L:L23	R:R:L93	2.77	No	No	0	0	5
391	R:R:A359	R:R:F360	2.77	No	No	0	6	4
392	R:R:E398	R:R:K401	2.7	No	No	0	8	7
393	R:R:A228	R:R:Y224	2.67	No	Yes	0	7	8
394	R:R:A267	R:R:Y224	2.67	No	Yes	0	3	8
395	R:R:L408	R:R:Q405	2.66	No	No	0	4	6
396	L:L:E15	R:R:L31	2.65	No	Yes	0	0	4
397	R:R:F248	R:R:S247	2.64	No	No	0	6	7
398	R:R:F390	R:R:V159	2.62	No	No	0	8	4
399	R:R:Q404	R:R:Q405	2.56	No	No	0	3	6
400	R:R:E328	R:R:Q327	2.55	Yes	No	0	7	5
401	R:R:I303	R:R:R299	2.51	No	Yes	0	4	6
402	R:R:F360	R:R:I303	2.51	No	No	0	4	4
403	R:R:T147	R:R:Y146	2.5	No	Yes	0	6	7
404	R:R:F167	R:R:K402	2.48	No	No	0	7	4
405	R:R:V220	R:R:W286	2.45	No	Yes	0	6	9
406	R:R:N100	R:R:R94	2.41	No	No	0	3	4
407	R:R:M321	R:R:Y337	2.39	Yes	No	0	5	7
408	R:R:Q53	R:R:R51	2.34	No	No	0	2	2
409	L:L:E15	R:R:R30	2.33	No	Yes	0	0	6
410	R:R:F193	R:R:Y150	2.06	No	Yes	0	8	7
411	R:R:G264	R:R:P266	2.03	No	Yes	0	7	9
412	R:R:C123	R:R:G124	1.96	No	No	0	9	3
413	R:R:A260	R:R:G257	1.95	No	No	0	1	2
414	R:R:G82	R:R:S79	1.86	No	No	0	6	7
415	R:R:G124	R:R:V127	1.84	No	No	0	3	2
416	R:R:G55	R:R:T54	1.82	No	No	0	3	3
417	R:R:P119	R:R:T115	1.75	No	No	0	8	4
418	R:R:G58	R:R:L57	1.71	No	No	0	1	3
419	R:R:G214	R:R:L217	1.71	No	No	0	2	4
420	R:R:A274	R:R:V220	1.7	No	No	0	5	6
421	R:R:G393	R:R:N392	1.7	No	No	0	4	9
422	R:R:D56	R:R:G55	1.68	No	No	0	3	3
423	R:R:A276	R:R:I297	1.62	No	No	0	4	8
424	R:R:A365	R:R:I368	1.62	No	No	0	3	4
425	R:R:V85	R:R:V87	1.6	Yes	No	0	7	5
426	R:R:G214	R:R:H211	1.59	No	No	0	2	7
427	R:R:G377	R:R:H354	1.59	No	Yes	0	7	8
428	R:R:A122	R:R:N126	1.56	No	No	0	5	3
429	R:R:C208	R:R:D209	1.56	No	No	0	4	4
430	R:R:K134	R:R:S130	1.53	No	No	0	1	2
431	R:R:M156	R:R:V155	1.52	No	No	0	6	4
432	R:R:L103	R:R:V85	1.49	Yes	Yes	2	7	7
433	R:R:N128	R:R:S130	1.49	No	No	0	4	2
434	R:R:D204	R:R:S202	1.47	No	No	0	4	3
435	R:R:L340	R:R:T344	1.47	No	No	0	8	8
436	R:R:D33	R:R:V37	1.46	Yes	No	0	6	5
437	R:R:E133	R:R:S137	1.44	No	No	0	2	1
438	R:R:K141	R:R:M145	1.44	No	No	0	4	6
439	L:L:Q24	R:R:V125	1.43	No	No	0	0	3
440	R:R:I268	R:R:L272	1.43	No	No	0	4	4
441	R:R:I275	R:R:L272	1.43	No	No	0	4	4
442	R:R:I297	R:R:L272	1.43	No	No	0	8	4
443	R:R:I294	R:R:L280	1.43	Yes	No	0	4	3
444	R:R:E333	R:R:V334	1.43	No	No	0	6	5
445	R:R:I348	R:R:L345	1.43	Yes	No	0	7	7
446	R:R:Q61	R:R:T59	1.42	Yes	No	0	2	2
447	R:R:G68	R:R:W70	1.41	No	Yes	0	4	7
448	R:R:L31	R:R:L35	1.38	Yes	No	0	4	2
449	R:R:L304	R:R:L307	1.38	No	No	0	3	3
450	L:L:L13	R:R:N132	1.37	Yes	No	0	0	3
451	R:R:K401	R:R:Q400	1.36	No	No	0	7	5
452	R:R:E48	R:R:L49	1.33	No	No	0	3	5
453	R:R:R99	R:R:S98	1.32	No	No	0	3	3
454	R:R:D56	R:R:Q61	1.31	No	Yes	0	3	2
455	R:R:F379	R:R:V148	1.31	No	No	0	7	5
456	R:R:H336	R:R:M321	1.31	No	Yes	0	6	5
457	R:R:E40	R:R:Q36	1.27	No	No	0	4	2
458	R:R:M84	R:R:R83	1.24	No	No	0	4	5
459	R:R:Q42	R:R:W39	1.1	Yes	No	0	5	3
460	R:R:Q404	R:R:W403	1.1	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	7.514	5	1	0
2	L:L:D3	7.48333	6	1	0
3	L:L:F6	6.11167	6	1	0
4	L:L:L10	5.36	5	1	0
5	L:L:L13	5.305	4	0	0
6	L:L:R14	5.4925	4	1	0
7	R:R:R30	6.43	4	0	6
8	R:R:L31	2.7375	4	0	4
9	R:R:D33	11.3025	4	9	6
10	R:R:Q42	7.855	4	10	5
11	R:R:Q61	2.5475	4	0	2
12	R:R:V63	5.964	5	2	1
13	R:R:P64	4.3975	4	0	1
14	R:R:E67	17.215	4	2	4
15	R:R:W70	8.525	4	10	7
16	R:R:W76	11.69	7	2	9
17	R:R:V85	4.946	5	2	7
18	R:R:P90	3.9475	4	0	8
19	R:R:L103	8.335	4	2	7
20	R:R:F104	8.864	5	2	5
21	R:R:R105	9.705	4	2	8
22	R:R:R135	7.4225	4	8	3
23	R:R:K143	6.01833	6	1	5
24	R:R:Y146	7.37875	8	1	7
25	R:R:Y150	6.89375	8	1	7
26	R:R:L157	3.8775	4	0	9
27	R:R:R174	4.58	4	3	9
28	R:R:N175	5.4975	4	3	8
29	R:R:H178	6.406	5	3	9
30	R:R:F185	9.308	5	0	8
31	R:R:R188	9.67	6	1	8
32	R:R:N192	7.27	6	1	8
33	R:R:K195	8.406	5	1	7
34	R:R:D196	6.32	4	1	7
35	R:R:F200	6.03857	7	1	4
36	R:R:Y207	6.47	4	12	4
37	R:R:F222	9.782	5	1	6
38	R:R:Q223	7.4275	4	1	7
39	R:R:Y224	4.1725	4	0	8
40	R:R:I226	10.7425	4	1	6
41	R:R:M227	4.68	4	0	6
42	R:R:Y230	10.358	5	1	8
43	R:R:S231	4.0675	4	7	5
44	R:R:W232	11.5467	6	6	9
45	R:R:L234	4.394	5	0	8
46	R:R:E236	10.7725	4	3	9
47	R:R:H241	7.54	4	0	8
48	R:R:F249	9.685	4	4	6
49	R:R:R252	7.9025	4	5	4
50	R:R:P266	3.968	5	7	9
51	R:R:W273	8.1825	4	1	8
52	R:R:R277	12.385	4	1	7
53	R:R:W286	10.995	6	1	9
54	R:R:D287	5.7925	4	0	6
55	R:R:I294	5.7	4	0	4
56	R:R:W295	10.406	5	1	6
57	R:R:I298	6.0425	4	0	7
58	R:R:R299	7.0375	4	0	6
59	R:R:F313	6.47143	7	3	9
60	R:R:M321	5.306	5	0	5
61	R:R:E328	6.6875	4	14	7
62	R:R:I348	3.62	4	3	7
63	R:R:L350	10.2075	4	3	8
64	R:R:F351	7.134	5	3	9
65	R:R:H354	7.38	5	1	8
66	R:R:Y355	10.1167	6	1	8
67	R:R:F358	8.46	5	1	7
68	R:R:M366	6.4175	4	8	5
69	R:R:L374	7.19	4	1	7
70	R:R:Q380	7.275	4	1	9
71	R:R:C389	4.0325	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G4	L:L:H1	14.8321	3.18	No	Yes	0	0	0
2	L:L:H1	R:R:Q223	34.8939	6.18	Yes	Yes	1	0	7
3	L:L:H1	R:R:I226	10.0243	18.56	Yes	Yes	1	0	6
4	L:L:H1	R:R:Y230	25.4736	4.36	Yes	Yes	1	0	8
5	R:R:Y230	R:R:Y355	14.7059	19.86	Yes	Yes	1	8	8
6	R:R:I226	R:R:R188	18.042	10.02	Yes	Yes	1	6	8
7	R:R:R188	R:R:Y150	36.069	10.29	Yes	Yes	1	8	7
8	R:R:R188	R:R:Y230	15.0606	11.32	Yes	Yes	1	8	8
9	L:L:G4	L:L:T7	14.3232	3.64	No	No	0	0	0
10	R:R:Y146	R:R:Y150	25.132	7.94	Yes	Yes	1	7	7
11	R:R:F222	R:R:Q223	48.626	8.2	Yes	Yes	1	6	7
12	R:R:F222	R:R:K195	19.8744	21.09	Yes	Yes	1	6	7
13	L:L:D3	R:R:L374	11.6022	12.21	Yes	Yes	1	0	7
14	L:L:F6	R:R:Y146	15.0185	13.41	Yes	Yes	1	0	7
15	L:L:F6	R:R:L370	24.1031	3.65	Yes	No	0	0	6
16	R:R:L370	R:R:M366	22.8578	4.24	No	Yes	0	6	5
17	L:L:T7	R:R:F200	21.4062	3.89	No	Yes	0	0	4
18	L:L:R14	R:R:F200	15.3471	6.41	Yes	Yes	1	0	4
19	L:L:S11	R:R:F200	14.4875	3.96	No	Yes	0	0	4
20	L:L:S11	R:R:D287	13.5358	8.83	No	Yes	0	0	6
21	R:R:F200	R:R:L199	15.4533	8.53	Yes	No	0	4	6
22	R:R:D287	R:R:L199	13.5498	4.07	Yes	No	0	6	6
23	L:L:R14	L:L:R18	15.6677	8.53	Yes	No	0	0	0
24	R:R:R30	R:R:V283	93.0393	3.92	Yes	No	0	6	3
25	R:R:E281	R:R:V283	93.7165	5.7	No	No	0	5	3
26	R:R:E281	R:R:R277	95.065	12.79	No	Yes	0	5	7
27	R:R:R277	R:R:W273	100	12	Yes	Yes	1	7	8
28	R:R:Q223	R:R:W273	82.4258	8.76	Yes	Yes	1	7	8
29	R:R:D33	R:R:R30	86.8539	16.68	Yes	Yes	0	6	6
30	R:R:D33	R:R:V34	83.9486	4.38	Yes	No	9	6	4
31	R:R:P90	R:R:V34	83.3475	3.53	Yes	No	0	8	4
32	R:R:P90	R:R:S74	74.0164	3.56	Yes	No	0	8	5
33	R:R:S74	R:R:V87	73.2871	4.85	No	No	0	5	5
34	R:R:V85	R:R:V87	63.5713	1.6	Yes	No	0	7	5
35	R:R:L103	R:R:V85	15.2249	1.49	Yes	Yes	2	7	7
36	R:R:E41	R:R:V87	10.8038	7.13	No	No	0	6	5
37	R:R:V85	R:R:W76	42.7242	4.9	Yes	Yes	2	7	9
38	R:R:V63	R:R:W76	22.6344	4.9	Yes	Yes	2	1	9
39	R:R:P64	R:R:V63	15.7799	3.53	Yes	Yes	0	1	1
40	R:R:E367	R:R:R135	16.3179	12.79	No	Yes	0	2	3
41	R:R:E367	R:R:Y138	15.0746	19.08	No	No	0	2	4
42	R:R:F371	R:R:Y138	12.582	4.13	No	No	0	6	4
43	R:R:A375	R:R:F371	10.0814	4.16	No	No	0	6	6
44	R:R:D196	R:R:F200	15.2359	4.78	Yes	Yes	1	7	4
45	R:R:N229	R:R:R188	70.6954	10.85	No	Yes	0	8	8
46	R:R:F185	R:R:N229	59.5279	18.12	Yes	No	0	8	8
47	R:R:F185	R:R:G381	16.2738	9.03	Yes	No	0	8	9
48	R:R:Q380	R:R:Y355	10.4301	3.38	Yes	Yes	1	9	8
49	R:R:F185	R:R:Q380	11.1023	9.37	Yes	Yes	0	8	9
50	R:R:F185	R:R:L181	53.4408	6.09	Yes	No	0	8	9
51	R:R:E236	R:R:L181	52.4169	11.93	Yes	No	0	9	9
52	R:R:E236	R:R:H178	36.057	11.08	Yes	Yes	3	9	9
53	R:R:H178	R:R:R174	34.2958	5.64	Yes	Yes	3	9	9
54	R:R:E394	R:R:R174	32.3943	3.49	No	Yes	0	9	9
55	R:R:E394	R:R:N392	31.2201	5.26	No	No	0	9	9
56	R:R:N392	R:R:V395	27.6857	5.91	No	No	0	9	9
57	R:R:L170	R:R:V395	16.9741	4.47	No	No	0	9	9
58	R:R:F167	R:R:L170	15.7739	7.31	No	No	0	7	9
59	R:R:E398	R:R:F167	13.3775	13.99	No	No	0	8	7
60	R:R:N229	R:R:S184	13.3675	7.45	No	No	0	8	9
61	R:R:S184	R:R:W232	12.4378	7.41	No	Yes	0	9	9
62	R:R:E236	R:R:L350	14.3713	13.25	Yes	Yes	3	9	8
63	R:R:M227	R:R:P266	39.2769	3.35	Yes	Yes	0	6	9
64	R:R:I298	R:R:M227	31.7671	5.83	Yes	Yes	0	7	6
65	R:R:C285	R:R:D287	23.2375	4.67	No	Yes	0	9	6
66	R:R:C215	R:R:C285	21.312	7.28	No	No	0	9	9
67	R:R:C215	R:R:Y207	13.5688	5.38	No	Yes	12	9	4
68	R:R:P266	R:R:S231	18.4277	5.34	Yes	Yes	7	9	5
69	R:R:F261	R:R:S231	17.7254	3.96	No	Yes	7	5	5
70	R:R:P266	R:R:S265	15.5244	3.56	Yes	No	7	9	4
71	R:R:F261	R:R:S265	15.1918	13.21	No	No	7	5	4
72	R:R:F261	R:R:L234	32.0156	3.65	No	Yes	0	5	8
73	R:R:I308	R:R:L234	17.0823	4.28	No	Yes	0	6	8
74	R:R:L234	R:R:N309	16.4731	4.12	Yes	No	0	8	9
75	R:R:F351	R:R:L350	16.1455	7.31	Yes	Yes	3	9	8
76	R:R:I308	R:R:L312	12.2414	2.85	No	No	0	6	8
77	R:R:H241	R:R:L312	11.0262	12.86	Yes	No	0	8	8
78	R:R:F313	R:R:F351	23.5711	5.36	Yes	Yes	3	9	9
79	R:R:F313	R:R:T344	15.4272	3.89	Yes	No	3	9	8
80	R:R:L340	R:R:T344	14.6939	1.47	No	No	0	8	8
81	R:R:L340	R:R:M321	13.9385	9.9	No	Yes	0	8	5
82	L:L:F6	R:R:L374	18.8956	3.65	Yes	Yes	1	0	7
83	R:R:M366	R:R:R135	17.9929	7.44	Yes	Yes	8	5	3
84	L:L:D3	R:R:F222	13.5007	3.58	Yes	Yes	1	0	6
85	L:L:D3	R:R:R188	18.9797	8.34	Yes	Yes	1	0	8
86	R:R:K143	R:R:Y146	11.5381	8.36	Yes	Yes	1	5	7
87	R:R:I298	R:R:W273	27.886	8.22	Yes	Yes	0	7	8
88	R:R:F351	R:R:N309	15.872	9.67	Yes	No	3	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:Q223	6.18	1	Yes	Yes	0	7	0	1
L:L:H1	R:R:I226	18.56	1	Yes	Yes	0	6	0	1
L:L:H1	R:R:Y230	4.36	1	Yes	Yes	0	8	0	1
L:L:H1	R:R:W295	5.29	1	Yes	Yes	0	6	0	1
L:L:S2	R:R:Q369	5.78	1	No	No	0	7	0	1
L:L:S2	R:R:E373	10.06	1	No	No	0	7	0	1
L:L:D3	R:R:Y150	5.75	1	Yes	Yes	0	7	0	1
L:L:D3	R:R:R188	8.34	1	Yes	Yes	0	8	0	1
L:L:D3	R:R:N192	9.42	1	Yes	Yes	0	8	0	1
L:L:D3	R:R:F222	3.58	1	Yes	Yes	0	6	0	1
L:L:D3	R:R:I226	5.6	1	Yes	Yes	0	6	0	1
L:L:D3	R:R:L374	12.21	1	Yes	Yes	0	7	0	1
L:L:T5	R:R:M366	4.52	0	No	Yes	0	5	0	1
L:L:F6	R:R:L139	4.87	1	Yes	No	0	4	0	1
L:L:F6	R:R:K143	7.44	1	Yes	Yes	0	5	0	1
L:L:F6	R:R:Y146	13.41	1	Yes	Yes	0	7	0	1
L:L:F6	R:R:L370	3.65	1	Yes	No	0	6	0	1
L:L:F6	R:R:L374	3.65	1	Yes	Yes	0	7	0	1
L:L:T7	R:R:K195	9.01	0	No	Yes	0	7	0	1
L:L:T7	R:R:F200	3.89	0	No	Yes	0	4	0	1
L:L:S8	R:R:N289	7.45	0	No	No	0	6	0	1
L:L:E9	R:R:R135	5.82	8	No	Yes	0	3	0	1
L:L:E9	R:R:M366	9.47	8	No	Yes	0	5	0	1
L:L:L10	R:R:L139	5.54	1	Yes	No	0	4	0	1
L:L:L10	R:R:K143	4.23	1	Yes	Yes	0	5	0	1
L:L:L10	R:R:F200	9.74	1	Yes	Yes	0	4	0	1
L:L:S11	R:R:F200	3.96	0	No	Yes	0	4	0	1
L:L:S11	R:R:D287	8.83	0	No	Yes	0	6	0	1
L:L:L13	R:R:R135	3.64	0	Yes	Yes	0	3	0	1
L:L:L13	R:R:H136	7.71	0	Yes	No	0	1	0	1
L:L:R14	R:R:H136	3.39	1	Yes	No	0	1	0	1
L:L:R14	R:R:F200	6.41	1	Yes	Yes	0	4	0	1
L:L:R18	R:R:V205	7.85	0	No	No	0	4	0	1
L:L:Q20	R:R:V125	5.73	0	No	No	0	3	0	1
L:L:Q20	R:R:D129	3.92	0	No	No	0	2	0	1
L:L:R21	R:R:D203	5.96	0	No	No	0	4	0	1
L:L:L22	R:R:L31	4.15	0	No	Yes	0	4	0	1
L:L:L23	R:R:V125	14.9	0	No	No	0	3	0	1
L:L:V27	R:R:P117	7.07	0	No	No	0	4	0	1
R:R:D33	R:R:R30	16.68	9	Yes	Yes	6	6	2	1
R:R:R30	R:R:V283	3.92	0	Yes	No	6	3	1	2
R:R:L93	R:R:P90	4.93	0	No	Yes	5	8	1	2
R:R:L93	R:R:L96	4.15	0	No	No	5	5	1	2
R:R:F116	R:R:P117	4.33	0	No	No	4	4	2	1
R:R:N132	R:R:S131	4.47	0	No	No	3	2	1	2
R:R:M366	R:R:R135	7.44	8	Yes	Yes	5	3	1	1
R:R:E367	R:R:R135	12.79	0	No	Yes	2	3	2	1
R:R:K143	R:R:Y146	8.36	1	Yes	Yes	5	7	1	1
R:R:D196	R:R:K143	8.3	1	Yes	Yes	7	5	2	1
R:R:F200	R:R:K143	4.96	1	Yes	Yes	4	5	1	1
R:R:Y146	R:R:Y150	7.94	1	Yes	Yes	7	7	1	1
R:R:N192	R:R:Y146	5.81	1	Yes	Yes	8	7	1	1
R:R:K195	R:R:Y146	3.58	1	Yes	Yes	7	7	1	1
R:R:D196	R:R:Y146	8.05	1	Yes	Yes	7	7	2	1
R:R:L374	R:R:Y146	9.38	1	Yes	Yes	7	7	1	1
R:R:R188	R:R:Y150	10.29	1	Yes	Yes	8	7	1	1
R:R:A189	R:R:Y150	4	0	No	Yes	8	7	2	1
R:R:N192	R:R:Y150	13.96	1	Yes	Yes	8	7	1	1
R:R:L374	R:R:Y150	3.52	1	Yes	Yes	7	7	1	1
R:R:S378	R:R:Y150	7.63	0	No	Yes	9	7	2	1
R:R:I226	R:R:R188	10.02	1	Yes	Yes	6	8	1	1
R:R:N229	R:R:R188	10.85	0	No	Yes	8	8	2	1
R:R:R188	R:R:Y230	11.32	1	Yes	Yes	8	8	1	1
R:R:R188	R:R:Y355	7.2	1	Yes	Yes	8	8	1	2
R:R:K195	R:R:N192	4.2	1	Yes	Yes	7	8	1	1
R:R:F222	R:R:N192	7.25	1	Yes	Yes	6	8	1	1
R:R:D196	R:R:K195	4.15	1	Yes	Yes	7	7	2	1
R:R:F222	R:R:K195	21.09	1	Yes	Yes	6	7	1	1
R:R:D196	R:R:F200	4.78	1	Yes	Yes	7	4	2	1
R:R:F200	R:R:L199	8.53	1	Yes	No	4	6	1	2
R:R:D287	R:R:L199	4.07	0	Yes	No	6	6	1	2
R:R:D203	R:R:S202	4.42	0	No	No	4	3	1	2
R:R:C208	R:R:V205	6.83	0	No	No	4	4	2	1
R:R:F222	R:R:Q223	8.2	1	Yes	Yes	6	7	1	1
R:R:F222	R:R:I226	8.79	1	Yes	Yes	6	6	1	1
R:R:Q223	R:R:W273	8.76	1	Yes	Yes	7	8	1	2
R:R:Q223	R:R:W295	6.57	1	Yes	Yes	7	6	1	1
R:R:V302	R:R:Y230	12.62	0	No	Yes	6	8	2	1
R:R:I306	R:R:Y230	3.63	1	No	Yes	7	8	2	1
R:R:Y230	R:R:Y355	19.86	1	Yes	Yes	8	8	1	2
R:R:I298	R:R:W273	8.22	0	Yes	Yes	7	8	2	2
R:R:C285	R:R:D287	4.67	0	No	Yes	9	6	2	1
R:R:D287	R:R:I288	5.6	0	Yes	No	6	5	1	2
R:R:N289	R:R:W295	27.12	0	No	Yes	6	6	1	1
R:R:I298	R:R:W295	7.05	0	Yes	Yes	7	6	2	1
R:R:R299	R:R:W295	6	0	Yes	Yes	6	6	2	1
R:R:I306	R:R:Y355	6.04	1	No	Yes	7	8	2	2
R:R:E373	R:R:Y355	8.98	1	No	Yes	7	8	1	2
R:R:F358	R:R:Q369	8.2	1	Yes	No	7	7	2	1
R:R:L370	R:R:M366	4.24	0	No	Yes	6	5	1	1
R:R:E373	R:R:Q369	12.74	1	No	No	7	7	1	1
R:R:N192	R:R:S191	2.98	1	Yes	No	8	5	1	2
R:R:K143	R:R:L140	2.82	1	Yes	No	5	3	1	2
R:R:C32	R:R:R30	2.79	0	No	Yes	6	6	2	1
L:L:L19	R:R:L31	2.77	0	No	Yes	0	4	0	1
L:L:L23	R:R:L93	2.77	0	No	No	0	5	0	1
L:L:E15	R:R:L31	2.65	0	No	Yes	0	4	0	1
R:R:T147	R:R:Y146	2.5	0	No	Yes	6	7	2	1
L:L:E15	R:R:R30	2.33	0	No	Yes	0	6	0	1
R:R:F193	R:R:Y150	2.06	0	No	Yes	8	7	2	1
L:L:Q24	R:R:V125	1.43	0	No	No	0	3	0	1
R:R:L31	R:R:L35	1.38	0	Yes	No	4	2	1	2
L:L:L13	R:R:N132	1.37	0	Yes	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6WZG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.18
Number of Linked Nodes	387
Number of Links	460
Number of Hubs	71
Number of Links mediated by Hubs	255
Number of Communities	14
Number of Nodes involved in Communities	108
Number of Links involved in Communities	158

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	207041
Length Of Smallest Path	3
Average Path Length	18.3912
Length of Longest Path	40
Minimum Path Strength	1.365
Average Path Strength	7.13418
Maximum Path Strength	28.31
Minimum Path Correlation	0.7
Average Path Correlation	0.966335
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	64.239
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.4704
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • response to nutrient levels • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • energy homeostasis • forebrain development • pallium development • telencephalon development • hippocampus development • limbic system development • regulation of localization • system process • transport • digestive system process • regulation of system process • negative regulation of biological process • negative regulation of gastrin-induced gastric acid secretion • negative regulation of transport • localization • negative regulation of secretion • gastrin-induced gastric acid secretion • regulation of gastrin-induced gastric acid secretion • regulation of multicellular organismal process • negative regulation of digestive system process • regulation of gastric acid secretion • secretion • regulation of transport • acid secretion • regulation of digestive system process • gastric acid secretion • establishment of localization • regulation of secretion • digestion • negative regulation of multicellular organismal process • negative regulation of gastric acid secretion • regulation of body fluid levels • secretion by tissue • pancreatic juice secretion • body fluid secretion • regulation of biological quality • positive regulation of biological process • positive regulation of secretion • positive regulation of digestive system process • positive regulation of pancreatic juice secretion • regulation of pancreatic juice secretion • positive regulation of transport • positive regulation of multicellular organismal process • regulation of synaptic plasticity • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • cell-cell signaling • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • regulation of appetite • digestive system development • tube development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • regulation of response to stimulus • positive regulation of signaling • lipid catabolic process • catabolic process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • positive regulation of catabolic process • positive regulation of metabolic process • positive regulation of lipid catabolic process • positive regulation of lipid metabolic process • regulation of metabolic process • lipid metabolic process • nitrogen compound transport • regulation of hormone secretion • regulation of peptide secretion • positive regulation of secretion by cell • positive regulation of somatostatin secretion • hormone secretion • somatostatin secretion • peptide secretion • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • amide transport • signal release • regulation of peptide hormone secretion • positive regulation of peptide secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • regulation of peptide transport • export from cell • peptide transport • regulation of somatostatin secretion • peptide hormone secretion • hormone transport • regulation of cellular component size • cell volume homeostasis • cellular component organization • cellular homeostasis • intracellular water homeostasis • chemical homeostasis • intracellular chemical homeostasis • cellular component organization or biogenesis • regulation of cell size • regulation of anatomical structure size • cellular anatomical structure • extracellular region • extracellular space • amide binding • binding • peptide hormone binding • hormone binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • secretin receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • cell surface receptor signaling pathway • cell periphery • plasma membrane • membrane • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • polymeric cytoskeletal fiber • intracellular anatomical structure • intracellular membraneless organelle • cytoplasmic microtubule • intracellular organelle • cytoskeleton • organelle • membraneless organelle • cytoplasm • supramolecular fiber • microtubule • supramolecular polymer • supramolecular complex • microtubule cytoskeleton • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • skeletal system development • bone development • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • protein localization • establishment of protein localization • cellular macromolecule localization • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular localization • regulation of protein localization • protein localization to extracellular region • regulation of establishment of protein localization • regulation of protein transport • protein transport • regulation of cellular localization • regulation of insulin secretion • macromolecule localization • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47872
Sequence	>6WZG_nogp_Chain_R R L C D V L Q V L W E E Q D Q C L Q E L S R E Q T G D L G T E Q P V P G C E G M W D N I S C W P S S V P G R M V E V E C P R F L R M L T S R N G S L F R N C T Q D G W S E T F P R P N L A C G V N V N D S S N E K R H S Y L L K L K V M Y T V G Y S S S L V M L L V A L G I L C A F R R L H C T R N Y I H M H L F V S F I L R A L S N F I K D A V L F S S D D V T Y C D A H R A G C K L V M V L F Q Y C I M A N Y S W L L V E G L Y L H T L L A I S F F S E R K Y L Q G F V A F G W G S P A I F V A L W A I A R H F L E D V G C W D I N A N A S I W W I I R G P V I L S I L I N F I L F I N I L R I L M R K L R T Q E T R G N E V S H Y K R L A R S T L L L I P L F G I H Y I V F A F S P E D A M E I Q L F F E L A L G S F Q G L V V A V L Y C F L N G E V Q L E V Q K K W Q Q W H L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	10.1038/s41467-020-17791-4
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	10.1038/s41467-020-17791-4

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