psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N132	R:R:S131	5.96	No	No	0	3	2
2	L:L:L13	R:R:N132	4.12	No	No	0	0	3
3	R:R:M366	R:R:R135	4.96	No	No	0	5	3
4	R:R:E367	R:R:R135	8.14	No	No	0	2	3
5	R:R:H136	R:R:L140	10.29	No	No	0	1	3
6	R:R:L142	R:R:Y138	11.72	No	No	0	6	4
7	R:R:E367	R:R:Y138	13.47	No	No	0	2	4
8	L:L:F6	R:R:L139	6.09	Yes	No	0	0	4
9	L:L:F6	R:R:L142	4.87	Yes	No	0	0	6
10	R:R:K143	R:R:Y146	7.17	No	Yes	1	5	7
11	R:R:D196	R:R:K143	6.91	No	No	1	7	5
12	L:L:F6	R:R:K143	7.44	Yes	No	1	0	5
13	R:R:Y146	R:R:Y150	5.96	Yes	Yes	1	7	7
14	R:R:N192	R:R:Y146	5.81	Yes	Yes	1	8	7
15	R:R:D196	R:R:Y146	8.05	No	Yes	1	7	7
16	L:L:F6	R:R:Y146	8.25	Yes	Yes	1	0	7
17	R:R:F379	R:R:G149	9.03	No	No	0	7	8
18	R:R:R188	R:R:Y150	10.29	Yes	Yes	1	8	7
19	R:R:A189	R:R:Y150	4	No	Yes	0	8	7
20	R:R:N192	R:R:Y150	13.96	Yes	Yes	1	8	7
21	R:R:S378	R:R:Y150	7.63	No	Yes	0	9	7
22	L:L:D3	R:R:Y150	8.05	Yes	Yes	1	0	7
23	R:R:I186	R:R:L154	4.28	No	No	0	7	6
24	R:R:L154	R:R:L190	4.15	No	No	0	6	4
25	R:R:F182	R:R:L157	8.53	Yes	No	0	8	9
26	R:R:I186	R:R:L157	4.28	No	No	0	7	9
27	R:R:A385	R:R:L157	4.73	No	No	0	8	9
28	R:R:A160	R:R:F182	4.16	No	Yes	0	9	8
29	R:R:L164	R:R:N175	6.87	No	Yes	0	8	8
30	R:R:L164	R:R:M179	5.65	No	No	0	8	6
31	R:R:E398	R:R:F167	10.49	Yes	Yes	5	8	7
32	R:R:F167	R:R:K402	11.17	Yes	No	5	7	4
33	R:R:E398	R:R:R169	9.3	Yes	No	0	8	7
34	R:R:L170	R:R:N175	4.12	No	Yes	0	9	8
35	R:R:L170	R:R:V395	5.96	No	No	0	9	9
36	R:R:E398	R:R:L170	6.63	Yes	No	0	8	9
37	R:R:T173	R:R:Y239	6.24	Yes	No	0	7	8
38	R:R:E251	R:R:T173	5.64	No	Yes	0	6	7
39	R:R:R252	R:R:T173	6.47	No	Yes	0	4	7
40	R:R:L255	R:R:T173	4.42	No	Yes	0	5	7
41	R:R:N175	R:R:R174	4.82	Yes	No	4	8	9
42	R:R:H178	R:R:R174	7.9	Yes	No	4	9	9
43	R:R:H178	R:R:N175	6.38	Yes	Yes	4	9	8
44	R:R:H180	R:R:Y176	17.42	Yes	No	0	8	6
45	R:R:L255	R:R:Y176	8.21	No	No	0	5	6
46	R:R:E236	R:R:I177	6.83	Yes	No	0	9	9
47	R:R:I177	R:R:Y239	8.46	No	No	0	9	8
48	R:R:E236	R:R:H178	9.85	Yes	Yes	0	9	9
49	R:R:H178	R:R:Y388	10.89	Yes	No	0	9	8
50	R:R:H180	R:R:W232	15.87	Yes	Yes	3	8	9
51	R:R:H180	R:R:V259	9.69	Yes	No	3	8	5
52	R:R:H180	R:R:W263	7.41	Yes	Yes	3	8	9
53	R:R:L181	R:R:S184	4.5	Yes	No	0	9	9
54	R:R:F185	R:R:L181	6.09	Yes	Yes	0	8	9
55	R:R:E236	R:R:L181	11.93	Yes	Yes	0	9	9
56	R:R:N229	R:R:S184	7.45	No	No	0	8	9
57	R:R:S184	R:R:W232	6.18	No	Yes	0	9	9
58	R:R:F185	R:R:N229	16.92	Yes	No	0	8	8
59	R:R:F185	R:R:Q380	8.2	Yes	Yes	0	8	9
60	R:R:F185	R:R:G381	9.03	Yes	No	0	8	9
61	R:R:C225	R:R:L187	4.76	No	No	0	6	6
62	R:R:I226	R:R:R188	8.77	Yes	Yes	1	6	8
63	R:R:N229	R:R:R188	12.05	No	Yes	0	8	8
64	R:R:R188	R:R:Y230	11.32	Yes	Yes	1	8	8
65	R:R:R188	R:R:Y355	4.12	Yes	Yes	1	8	8
66	L:L:D3	R:R:R188	7.15	Yes	Yes	1	0	8
67	R:R:C225	R:R:S191	6.89	No	No	0	6	5
68	R:R:F222	R:R:N192	4.83	Yes	Yes	0	6	8
69	L:L:D3	R:R:N192	14.81	Yes	Yes	1	0	8
70	R:R:D196	R:R:K195	5.53	No	No	0	7	7
71	R:R:F222	R:R:K195	12.41	Yes	No	0	6	7
72	L:L:T7	R:R:K195	10.51	No	No	0	0	7
73	R:R:V198	R:R:V218	6.41	No	No	0	4	6
74	R:R:F200	R:R:L199	8.53	Yes	No	0	4	6
75	R:R:D287	R:R:L199	9.5	Yes	No	0	6	6
76	L:L:T7	R:R:F200	5.19	No	Yes	0	0	4
77	L:L:L10	R:R:F200	15.83	No	Yes	0	0	4
78	L:L:R14	R:R:F200	8.55	No	Yes	0	0	4
79	R:R:G214	R:R:H211	4.77	No	No	0	2	7
80	R:R:C215	R:R:C285	7.28	No	No	0	9	9
81	R:R:D282	R:R:K216	9.68	No	No	7	6	8
82	R:R:K216	R:R:W286	29.01	No	Yes	7	8	9
83	R:R:D287	R:R:M219	4.16	Yes	No	0	6	6
84	R:R:F222	R:R:Q223	5.86	Yes	Yes	0	6	7
85	R:R:F222	R:R:I226	8.79	Yes	Yes	0	6	6
86	R:R:Q223	R:R:W273	9.86	Yes	No	1	7	8
87	R:R:Q223	R:R:W295	5.48	Yes	Yes	1	7	6
88	R:R:I298	R:R:Q223	9.61	Yes	Yes	1	7	7
89	L:L:H1	R:R:Q223	8.65	Yes	Yes	1	0	7
90	R:R:W263	R:R:Y224	4.82	Yes	Yes	0	9	8
91	R:R:P266	R:R:Y224	5.56	Yes	Yes	0	9	8
92	R:R:V270	R:R:Y224	5.05	No	Yes	0	7	8
93	L:L:H1	R:R:I226	17.23	Yes	Yes	1	0	6
94	L:L:D3	R:R:I226	8.4	Yes	Yes	1	0	6
95	R:R:M227	R:R:P266	5.03	No	Yes	0	6	9
96	R:R:F269	R:R:M227	4.98	No	No	0	6	6
97	R:R:I298	R:R:M227	5.83	Yes	No	0	7	6
98	R:R:V302	R:R:Y230	13.88	No	Yes	0	6	8
99	R:R:Y230	R:R:Y355	15.89	Yes	Yes	1	8	8
100	L:L:H1	R:R:Y230	4.36	Yes	Yes	1	0	8
101	R:R:P266	R:R:S231	7.13	Yes	No	0	9	5
102	R:R:V235	R:R:W232	8.58	No	Yes	0	8	9
103	R:R:V259	R:R:W232	7.36	No	Yes	3	5	9
104	R:R:G262	R:R:W232	7.04	No	Yes	0	8	9
105	R:R:W232	R:R:W263	23.43	Yes	Yes	3	9	9
106	R:R:L233	R:R:Q380	3.99	No	Yes	0	9	9
107	R:R:L234	R:R:L238	4.15	Yes	No	0	8	6
108	R:R:L234	R:R:S305	7.51	Yes	No	0	8	7
109	R:R:E236	R:R:L350	14.58	Yes	No	0	9	8
110	R:R:F351	R:R:G237	9.03	Yes	No	0	9	8
111	R:R:L238	R:R:L312	4.15	No	No	0	6	8
112	R:R:L243	R:R:Y239	8.21	No	No	0	8	8
113	R:R:L240	R:R:L244	4.15	No	No	0	9	8
114	R:R:I316	R:R:L240	7.14	No	No	0	8	9
115	R:R:F351	R:R:L240	4.87	Yes	No	0	9	9
116	R:R:A245	R:R:H241	7.32	No	Yes	0	6	8
117	R:R:H241	R:R:L312	14.14	Yes	No	0	8	8
118	R:R:H241	R:R:N315	8.93	Yes	No	0	8	7
119	R:R:H241	R:R:I316	3.98	Yes	No	0	8	8
120	R:R:I246	R:R:T242	4.56	No	No	0	4	7
121	R:R:E251	R:R:L243	3.98	No	No	0	6	8
122	R:R:E251	R:R:F249	7	No	No	0	6	6
123	R:R:F249	R:R:Y254	18.57	No	Yes	0	6	4
124	R:R:K253	R:R:S250	4.59	No	No	0	6	6
125	R:R:K253	R:R:Q256	6.78	No	No	0	6	3
126	R:R:F258	R:R:Y254	4.13	No	Yes	0	7	4
127	R:R:F261	R:R:S265	13.21	No	No	0	5	4
128	R:R:F269	R:R:P301	17.34	No	No	0	6	9
129	R:R:R277	R:R:W273	12	No	No	0	7	8
130	R:R:I298	R:R:W273	10.57	Yes	No	1	7	8
131	R:R:E281	R:R:R277	10.47	Yes	No	0	5	7
132	R:R:R277	R:R:W286	20.99	No	Yes	0	7	9
133	R:R:F279	R:R:H278	9.05	No	No	0	3	2
134	R:R:I294	R:R:L280	5.71	No	No	0	4	3
135	R:R:E281	R:R:N291	5.26	Yes	No	0	5	5
136	R:R:D282	R:R:W286	11.17	No	Yes	7	6	9
137	R:R:C285	R:R:D287	6.22	No	Yes	0	9	6
138	R:R:D287	R:R:I288	4.2	Yes	No	6	6	5
139	L:L:S11	R:R:D287	8.83	No	Yes	6	0	6
140	L:L:S11	R:R:I288	6.19	No	No	6	0	5
141	R:R:N289	R:R:W295	23.73	No	Yes	0	6	6
142	L:L:S8	R:R:N289	8.94	No	No	0	0	6
143	R:R:I294	R:R:N291	8.5	No	No	0	4	5
144	R:R:I298	R:R:W295	4.7	Yes	Yes	1	7	6
145	R:R:R299	R:R:W295	11	No	Yes	0	6	6
146	L:L:H1	R:R:W295	6.35	Yes	Yes	1	0	6
147	R:R:R299	R:R:W296	8	No	No	0	6	7
148	R:R:G300	R:R:P301	4.06	No	No	0	4	9
149	R:R:I306	R:R:Y355	6.04	No	Yes	0	7	8
150	R:R:F351	R:R:N309	12.08	Yes	No	0	9	9
151	R:R:F310	R:R:I314	6.28	No	No	0	7	4
152	R:R:F310	R:R:I356	15.07	No	No	0	7	5
153	R:R:F313	R:R:L317	7.31	Yes	No	2	9	6
154	R:R:F313	R:R:T344	5.19	Yes	No	2	9	8
155	R:R:F313	R:R:L347	7.31	Yes	No	2	9	9
156	R:R:F313	R:R:F351	5.36	Yes	Yes	2	9	9
157	R:R:F313	R:R:I353	15.07	Yes	No	0	9	5
158	R:R:N315	R:R:R318	7.23	No	No	0	7	7
159	R:R:L317	R:R:T344	7.37	No	No	2	6	8
160	R:R:R318	R:R:R322	4.26	No	No	0	7	7
161	R:R:M321	R:R:R325	6.2	No	No	0	5	6
162	R:R:L340	R:R:M321	9.9	No	No	0	8	5
163	R:R:E333	R:R:Y337	4.49	No	No	0	6	7
164	R:R:R339	R:R:R342	4.26	No	No	0	8	8
165	R:R:L346	R:R:R342	7.29	No	No	0	8	8
166	R:R:F351	R:R:L347	9.74	Yes	No	2	9	9
167	R:R:I348	R:R:P349	5.08	No	No	0	7	8
168	R:R:I348	R:R:I353	5.89	No	No	0	7	5
169	R:R:F351	R:R:L350	6.09	Yes	No	0	9	8
170	R:R:L350	R:R:Y388	24.62	No	No	0	8	8
171	R:R:H354	R:R:Y355	17.42	No	Yes	0	8	8
172	R:R:H354	R:R:Q380	12.36	No	Yes	0	8	9
173	R:R:E373	R:R:Y355	8.98	No	Yes	0	7	8
174	R:R:F358	R:R:V357	5.24	Yes	No	0	7	5
175	R:R:F358	R:R:S361	5.28	Yes	No	8	7	5
176	R:R:F358	R:R:Q369	11.71	Yes	No	8	7	7
177	R:R:F358	R:R:F372	8.57	Yes	No	0	7	5
178	R:R:A359	R:R:F360	4.16	No	No	0	6	4
179	R:R:Q369	R:R:S361	5.78	No	No	8	7	5
180	R:R:D364	R:R:P362	4.83	No	No	0	5	6
181	R:R:L370	R:R:M366	4.24	No	No	0	6	5
182	L:L:S2	R:R:L370	6.01	No	No	0	0	6
183	R:R:A375	R:R:F371	5.55	No	No	0	6	6
184	R:R:F372	R:R:L376	6.09	No	No	0	5	6
185	L:L:S2	R:R:E373	10.06	No	No	0	0	7
186	L:L:S2	R:R:L374	4.5	No	No	0	0	7
187	L:L:D3	R:R:L374	5.43	Yes	No	0	0	7
188	L:L:F6	R:R:L374	4.87	Yes	No	0	0	7
189	R:R:L387	R:R:Y388	4.69	No	No	0	7	8
190	R:R:C389	R:R:F390	5.59	No	No	0	8	8
191	R:R:E394	R:R:N392	11.83	No	No	0	9	9
192	R:R:N392	R:R:V395	5.91	No	No	0	9	9
193	R:R:E398	R:R:K402	6.75	Yes	No	5	8	4
194	R:R:Q404	R:R:W403	4.38	No	No	0	3	4
195	L:L:E9	L:L:R12	9.3	No	No	0	0	0
196	L:L:L13	L:L:R12	4.86	No	No	0	0	0
197	L:L:L19	L:L:L23	4.15	No	No	0	0	0
198	L:L:Q20	L:L:Q24	12.8	No	No	0	0	0
199	R:R:F193	R:R:S151	3.96	No	No	0	8	6
200	R:R:F222	R:R:S191	3.96	Yes	No	0	6	5
201	R:R:F379	R:R:S378	3.96	No	No	0	7	9
202	R:R:F390	R:R:V159	3.93	No	No	0	8	4
203	R:R:F167	R:R:V399	3.93	Yes	No	0	7	4
204	R:R:F390	R:R:V386	3.93	No	No	0	8	5
205	R:R:H336	R:R:L324	3.86	No	No	0	6	7
206	R:R:E373	R:R:Q369	3.82	No	No	0	7	7
207	R:R:F279	R:R:I275	3.77	No	No	0	3	4
208	R:R:F360	R:R:I303	3.77	No	No	0	4	4
209	R:R:F310	R:R:I353	3.77	No	No	0	7	5
210	R:R:A228	R:R:P266	3.74	No	Yes	0	7	9
211	R:R:G149	R:R:V148	3.68	No	No	0	8	5
212	R:R:V183	R:R:W263	3.68	No	Yes	0	4	9
213	R:R:F182	R:R:L161	3.65	Yes	No	0	8	6
214	R:R:F182	R:R:L181	3.65	Yes	Yes	0	8	9
215	R:R:F261	R:R:L234	3.65	No	Yes	0	5	8
216	L:L:L13	R:R:R135	3.64	No	No	0	0	3
217	R:R:A160	R:R:C389	3.61	No	No	0	9	8
218	R:R:P362	R:R:S361	3.56	No	No	0	6	5
219	R:R:P349	R:R:V383	3.53	No	No	0	8	6
220	R:R:G393	R:R:N392	3.39	No	No	0	4	9
221	R:R:C389	R:R:I163	3.27	No	No	0	8	8
222	R:R:A276	R:R:I294	3.25	No	No	0	4	4
223	R:R:G377	R:R:H354	3.18	No	No	0	7	8
224	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
225	R:R:C225	R:R:L221	3.17	No	No	0	6	4
226	R:R:C172	R:R:N175	3.15	No	Yes	0	8	8
227	R:R:F371	R:R:Y138	3.09	No	No	0	6	4
228	R:R:I194	R:R:V218	3.07	No	No	0	5	6
229	R:R:M156	R:R:V155	3.04	No	No	0	6	4
230	R:R:K338	R:R:V334	3.04	No	No	0	6	5
231	R:R:A290	R:R:E281	3.02	No	Yes	0	4	5
232	L:L:T5	R:R:M366	3.01	No	No	0	0	5
233	R:R:L320	R:R:S343	3	No	No	0	8	9
234	R:R:N291	R:R:S293	2.98	No	No	0	5	1
235	R:R:L382	R:R:V383	2.98	Yes	No	0	5	6
236	R:R:L382	R:R:V386	2.98	Yes	No	0	5	5
237	R:R:C215	R:R:H211	2.95	No	No	0	9	7
238	R:R:G352	R:R:Y355	2.9	No	Yes	0	9	8
239	R:R:Q380	R:R:V384	2.87	Yes	No	0	9	9
240	R:R:I186	R:R:L158	2.85	No	No	0	7	4
241	R:R:I308	R:R:L234	2.85	No	Yes	0	6	8
242	R:R:I319	R:R:L244	2.85	No	No	0	7	8
243	R:R:I297	R:R:L272	2.85	No	No	0	8	4
244	R:R:E281	R:R:V283	2.85	Yes	No	0	5	3
245	R:R:I308	R:R:L312	2.85	No	No	0	6	8
246	R:R:L382	R:R:M156	2.83	Yes	No	0	5	6
247	R:R:A166	R:R:F167	2.77	No	Yes	0	3	7
248	R:R:L320	R:R:L340	2.77	No	No	0	8	8
249	R:R:L387	R:R:L391	2.77	No	No	0	7	5
250	L:L:E15	R:R:I288	2.73	No	No	0	0	5
251	R:R:A267	R:R:Y224	2.67	No	Yes	0	3	8
252	R:R:A292	R:R:W296	2.59	No	No	0	5	7
253	R:R:R322	R:R:T326	2.59	No	No	0	7	6
254	L:L:L10	R:R:H136	2.57	No	No	0	0	1
255	R:R:S153	R:R:Y150	2.54	No	Yes	0	9	7
256	R:R:D282	R:R:H278	2.52	No	No	0	6	2
257	R:R:F358	R:R:I368	2.51	Yes	No	0	7	4
258	R:R:T242	R:R:Y254	2.5	No	Yes	0	7	4
259	R:R:E333	R:R:H336	2.46	No	No	0	6	6
260	R:R:V220	R:R:W286	2.45	No	Yes	0	6	9
261	R:R:F360	R:R:L307	2.44	No	No	0	4	3
262	R:R:L324	R:R:R339	2.43	No	No	0	7	8
263	R:R:M321	R:R:Y337	2.39	No	No	0	5	7
264	R:R:R322	R:R:R325	2.13	No	No	0	7	6
265	L:L:R18	L:L:R21	2.13	No	No	0	0	0
266	R:R:F193	R:R:Y150	2.06	No	Yes	0	8	7
267	R:R:G264	R:R:P266	2.03	No	Yes	0	7	9
268	R:R:A213	R:R:G214	1.95	No	No	0	3	2
269	R:R:A260	R:R:G257	1.95	No	No	0	1	2
270	R:R:C215	R:R:V198	1.71	No	No	0	9	4
271	L:L:G16	L:L:L19	1.71	No	No	0	0	0
272	R:R:A274	R:R:V220	1.7	No	No	0	5	6
273	R:R:G257	R:R:Q256	1.64	No	No	0	2	3
274	R:R:G393	R:R:Q396	1.64	No	No	0	4	7
275	L:L:E15	L:L:G16	1.64	No	No	0	0	0
276	L:L:G25	L:L:Q24	1.64	No	No	0	0	0
277	R:R:C165	R:R:M179	1.62	No	No	0	2	6
278	R:R:A276	R:R:I297	1.62	No	No	0	4	8
279	R:R:S335	R:R:V334	1.62	No	No	0	6	5
280	R:R:A365	R:R:I368	1.62	No	No	0	3	4
281	R:R:S151	R:R:T147	1.6	No	No	0	6	6
282	R:R:L382	R:R:S152	1.5	Yes	No	0	5	5
283	R:R:L345	R:R:T344	1.47	No	No	0	7	8
284	R:R:E133	R:R:S130	1.44	No	No	0	2	2
285	R:R:K141	R:R:M145	1.44	No	No	0	4	6
286	R:R:K401	R:R:K402	1.44	No	No	0	7	4
287	R:R:I356	R:R:L307	1.43	No	No	0	5	3
288	R:R:Q327	R:R:T326	1.42	No	No	0	5	6
289	R:R:L397	R:R:Q400	1.33	No	No	0	4	5
290	L:L:L23	L:L:Q20	1.33	No	No	0	0	0
291	R:R:Q404	R:R:Q405	1.28	No	No	0	3	6
292	R:R:S250	R:R:Y254	1.27	No	Yes	0	6	4
293	R:R:K216	R:R:R212	1.24	No	No	0	8	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y146	7.048	5	1	7
2	R:R:Y150	6.81125	8	1	7
3	R:R:F167	7.09	4	5	7
4	R:R:T173	5.6925	4	0	7
5	R:R:N175	5.068	5	4	8
6	R:R:H178	8.755	4	4	9
7	R:R:H180	12.5975	4	3	8
8	R:R:L181	6.5425	4	0	9
9	R:R:F182	4.9975	4	0	8
10	R:R:F185	10.06	4	0	8
11	R:R:R188	8.95	6	1	8
12	R:R:N192	9.8525	4	1	8
13	R:R:F200	9.525	4	0	4
14	R:R:F222	7.17	5	0	6
15	R:R:Q223	7.892	5	1	7
16	R:R:Y224	4.525	4	0	8
17	R:R:I226	10.7975	4	1	6
18	R:R:Y230	11.3625	4	1	8
19	R:R:W232	11.41	6	3	9
20	R:R:L234	4.54	4	0	8
21	R:R:E236	10.7975	4	0	9
22	R:R:H241	8.5925	4	0	8
23	R:R:Y254	6.6175	4	0	4
24	R:R:W263	9.835	4	3	9
25	R:R:P266	4.698	5	0	9
26	R:R:E281	5.4	4	0	5
27	R:R:W286	15.905	4	7	9
28	R:R:D287	6.582	5	6	6
29	R:R:W295	10.252	5	1	6
30	R:R:I298	7.6775	4	1	7
31	R:R:F313	8.048	5	2	9
32	R:R:F351	7.86167	6	2	9
33	R:R:Y355	9.225	6	1	8
34	R:R:F358	6.662	5	8	7
35	R:R:Q380	6.855	4	0	9
36	R:R:L382	2.5725	4	0	5
37	R:R:E398	8.2925	4	5	8
38	L:L:H1	7.954	5	1	0
39	L:L:D3	8.768	5	1	0
40	L:L:F6	6.304	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M366	R:R:R135	11.5354	4.96	No	No	0	5	3
2	L:L:L13	R:R:R135	10.743	3.64	No	No	0	0	3
3	L:L:T7	R:R:F200	22.9228	5.19	No	Yes	0	0	4
4	L:L:T7	R:R:K195	23.7871	10.51	No	No	0	0	7
5	R:R:L370	R:R:M366	15.7827	4.24	No	No	0	6	5
6	L:L:S2	R:R:L370	17.9042	6.01	No	No	0	0	6
7	L:L:S2	R:R:L374	10.2253	4.5	No	No	0	0	7
8	L:L:D3	R:R:L374	14.8614	5.43	Yes	No	0	0	7
9	L:L:S2	R:R:E373	10.6479	10.06	No	No	0	0	7
10	R:R:E373	R:R:Y355	22.1537	8.98	No	Yes	0	7	8
11	R:R:R188	R:R:Y355	16.6343	4.12	Yes	Yes	1	8	8
12	L:L:D3	R:R:R188	12.2919	7.15	Yes	Yes	1	0	8
13	R:R:F182	R:R:L181	20.7168	3.65	Yes	Yes	0	8	9
14	R:R:L181	R:R:S184	51.3038	4.5	Yes	No	0	9	9
15	R:R:N229	R:R:S184	52.6709	7.45	No	No	0	8	9
16	R:R:N229	R:R:R188	100	12.05	No	Yes	0	8	8
17	R:R:F185	R:R:L181	55.0503	6.09	Yes	Yes	0	8	9
18	R:R:F185	R:R:N229	48.0095	16.92	Yes	No	0	8	8
19	R:R:A160	R:R:F182	11.808	4.16	No	Yes	0	9	8
20	R:R:H178	R:R:N175	22.4347	6.38	Yes	Yes	4	9	8
21	R:R:E236	R:R:H178	25.5093	9.85	Yes	Yes	0	9	9
22	R:R:E236	R:R:L181	91.2455	11.93	Yes	Yes	0	9	9
23	R:R:L170	R:R:N175	16.3553	4.12	No	Yes	0	9	8
24	R:R:E236	R:R:I177	21.0358	6.83	Yes	No	0	9	9
25	R:R:I177	R:R:Y239	19.9772	8.46	No	No	0	9	8
26	R:R:T173	R:R:Y239	10.0287	6.24	Yes	No	0	7	8
27	R:R:S184	R:R:W232	10.4133	6.18	No	Yes	0	9	9
28	R:R:E251	R:R:T173	11.7763	5.64	No	Yes	0	6	7
29	R:R:E236	R:R:L350	58.2368	14.58	Yes	No	0	9	8
30	R:R:F222	R:R:I226	32.5649	8.79	Yes	Yes	0	6	6
31	R:R:F200	R:R:L199	18.5889	8.53	Yes	No	0	4	6
32	R:R:D287	R:R:L199	17.6993	9.5	Yes	No	0	6	6
33	R:R:R277	R:R:W286	15.7256	20.99	No	Yes	0	7	9
34	R:R:R277	R:R:W273	34.4836	12	No	No	0	7	8
35	R:R:Q223	R:R:W273	34.211	9.86	Yes	No	1	7	8
36	R:R:F222	R:R:Q223	17.2555	5.86	Yes	Yes	0	6	7
37	L:L:H1	R:R:Q223	23.9118	8.65	Yes	Yes	1	0	7
38	L:L:H1	R:R:I226	16.8054	17.23	Yes	Yes	1	0	6
39	L:L:H1	R:R:Y230	18.2592	4.36	Yes	Yes	1	0	8
40	R:R:H241	R:R:L312	13.1308	14.14	Yes	No	0	8	8
41	R:R:H241	R:R:I316	34.5723	3.98	Yes	No	0	8	8
42	R:R:I316	R:R:L240	35.6352	7.14	No	No	0	8	9
43	R:R:F351	R:R:L240	38.8408	4.87	Yes	No	0	9	9
44	R:R:F351	R:R:L350	56.876	6.09	Yes	No	0	9	8
45	R:R:H241	R:R:N315	20.0363	8.93	Yes	No	0	8	7
46	R:R:F249	R:R:Y254	16.2159	18.57	No	Yes	0	6	4
47	R:R:E251	R:R:F249	17.9782	7	No	No	0	6	6
48	R:R:E281	R:R:R277	17.452	10.47	Yes	No	0	5	7
49	R:R:E281	R:R:N291	12.2602	5.26	Yes	No	0	5	5
50	R:R:F313	R:R:I353	12.463	15.07	Yes	No	0	9	5
51	R:R:F313	R:R:F351	16.9005	5.36	Yes	Yes	2	9	9
52	R:R:N315	R:R:R318	18.8889	7.23	No	No	0	7	7
53	R:R:R318	R:R:R322	17.7373	4.26	No	No	0	7	7
54	R:R:M321	R:R:R325	13.0885	6.2	No	No	0	5	6
55	R:R:R322	R:R:R325	14.257	2.13	No	No	0	7	6
56	R:R:E373	R:R:Q369	11.4931	3.82	No	No	0	7	7
57	R:R:A160	R:R:C389	10.6796	3.61	No	No	0	9	8
58	R:R:F222	R:R:K195	22.0628	12.41	Yes	No	0	6	7
59	R:R:R188	R:R:Y150	13.8239	10.29	Yes	Yes	1	8	7
60	R:R:R188	R:R:Y230	16.3363	11.32	Yes	Yes	1	8	8
61	R:R:I226	R:R:R188	46.412	8.77	Yes	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N132	R:R:S131	5.96	0	No	No	3	2	1	2
L:L:L13	R:R:N132	4.12	0	No	No	0	3	0	1
R:R:M366	R:R:R135	4.96	0	No	No	5	3	1	1
R:R:E367	R:R:R135	8.14	0	No	No	2	3	2	1
R:R:H136	R:R:L140	10.29	0	No	No	1	3	1	2
R:R:L142	R:R:Y138	11.72	0	No	No	6	4	1	2
R:R:E367	R:R:Y138	13.47	0	No	No	2	4	2	2
L:L:F6	R:R:L139	6.09	1	Yes	No	0	4	0	1
L:L:F6	R:R:L142	4.87	1	Yes	No	0	6	0	1
R:R:K143	R:R:Y146	7.17	1	No	Yes	5	7	1	1
R:R:D196	R:R:K143	6.91	1	No	No	7	5	2	1
L:L:F6	R:R:K143	7.44	1	Yes	No	0	5	0	1
R:R:Y146	R:R:Y150	5.96	1	Yes	Yes	7	7	1	1
R:R:N192	R:R:Y146	5.81	1	Yes	Yes	8	7	1	1
R:R:D196	R:R:Y146	8.05	1	No	Yes	7	7	2	1
L:L:F6	R:R:Y146	8.25	1	Yes	Yes	0	7	0	1
R:R:R188	R:R:Y150	10.29	1	Yes	Yes	8	7	1	1
R:R:A189	R:R:Y150	4	0	No	Yes	8	7	2	1
R:R:N192	R:R:Y150	13.96	1	Yes	Yes	8	7	1	1
R:R:S378	R:R:Y150	7.63	0	No	Yes	9	7	2	1
L:L:D3	R:R:Y150	8.05	1	Yes	Yes	0	7	0	1
R:R:I226	R:R:R188	8.77	1	Yes	Yes	6	8	1	1
R:R:N229	R:R:R188	12.05	0	No	Yes	8	8	2	1
R:R:R188	R:R:Y230	11.32	1	Yes	Yes	8	8	1	1
R:R:R188	R:R:Y355	4.12	1	Yes	Yes	8	8	1	2
L:L:D3	R:R:R188	7.15	1	Yes	Yes	0	8	0	1
R:R:F222	R:R:N192	4.83	0	Yes	Yes	6	8	2	1
L:L:D3	R:R:N192	14.81	1	Yes	Yes	0	8	0	1
R:R:D196	R:R:K195	5.53	1	No	No	7	7	2	1
R:R:F222	R:R:K195	12.41	0	Yes	No	6	7	2	1
L:L:T7	R:R:K195	10.51	0	No	No	0	7	0	1
R:R:F200	R:R:L199	8.53	0	Yes	No	4	6	1	2
R:R:D287	R:R:L199	9.5	6	Yes	No	6	6	1	2
L:L:T7	R:R:F200	5.19	0	No	Yes	0	4	0	1
L:L:L10	R:R:F200	15.83	0	No	Yes	0	4	0	1
L:L:R14	R:R:F200	8.55	0	No	Yes	0	4	0	1
R:R:D287	R:R:M219	4.16	6	Yes	No	6	6	1	2
R:R:F222	R:R:Q223	5.86	0	Yes	Yes	6	7	2	1
R:R:F222	R:R:I226	8.79	0	Yes	Yes	6	6	2	1
R:R:Q223	R:R:W273	9.86	1	Yes	No	7	8	1	2
R:R:Q223	R:R:W295	5.48	1	Yes	Yes	7	6	1	1
R:R:I298	R:R:Q223	9.61	1	Yes	Yes	7	7	2	1
L:L:H1	R:R:Q223	8.65	1	Yes	Yes	0	7	0	1
L:L:H1	R:R:I226	17.23	1	Yes	Yes	0	6	0	1
L:L:D3	R:R:I226	8.4	1	Yes	Yes	0	6	0	1
R:R:V302	R:R:Y230	13.88	0	No	Yes	6	8	2	1
R:R:Y230	R:R:Y355	15.89	1	Yes	Yes	8	8	1	2
L:L:H1	R:R:Y230	4.36	1	Yes	Yes	0	8	0	1
R:R:I298	R:R:W273	10.57	1	Yes	No	7	8	2	2
R:R:C285	R:R:D287	6.22	0	No	Yes	9	6	2	1
R:R:D287	R:R:I288	4.2	6	Yes	No	6	5	1	1
L:L:S11	R:R:D287	8.83	6	No	Yes	0	6	0	1
L:L:S11	R:R:I288	6.19	6	No	No	0	5	0	1
R:R:N289	R:R:W295	23.73	0	No	Yes	6	6	1	1
L:L:S8	R:R:N289	8.94	0	No	No	0	6	0	1
R:R:I298	R:R:W295	4.7	1	Yes	Yes	7	6	2	1
R:R:R299	R:R:W295	11	0	No	Yes	6	6	2	1
L:L:H1	R:R:W295	6.35	1	Yes	Yes	0	6	0	1
R:R:E373	R:R:Y355	8.98	0	No	Yes	7	8	1	2
R:R:L370	R:R:M366	4.24	0	No	No	6	5	1	1
L:L:S2	R:R:L370	6.01	0	No	No	0	6	0	1
L:L:S2	R:R:E373	10.06	0	No	No	0	7	0	1
L:L:S2	R:R:L374	4.5	0	No	No	0	7	0	1
L:L:D3	R:R:L374	5.43	1	Yes	No	0	7	0	1
L:L:F6	R:R:L374	4.87	1	Yes	No	0	7	0	1
R:R:E373	R:R:Q369	3.82	0	No	No	7	7	1	2
L:L:L13	R:R:R135	3.64	0	No	No	0	3	0	1
L:L:T5	R:R:M366	3.01	0	No	No	0	5	0	1
L:L:E15	R:R:I288	2.73	0	No	No	0	5	0	1
L:L:L10	R:R:H136	2.57	0	No	No	0	1	0	1
R:R:S153	R:R:Y150	2.54	0	No	Yes	9	7	2	1
R:R:F193	R:R:Y150	2.06	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7D3S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.98
Number of Linked Nodes	266
Number of Links	293
Number of Hubs	40
Number of Links mediated by Hubs	148
Number of Communities	8
Number of Nodes involved in Communities	40
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	75983
Length Of Smallest Path	3
Average Path Length	14.6441
Length of Longest Path	37
Minimum Path Strength	1.675
Average Path Strength	8.09054
Maximum Path Strength	25
Minimum Path Correlation	0.7
Average Path Correlation	0.939075
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	54.191
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.1974
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • amide binding • peptide hormone binding • hormone binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • secretin receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • response to nutrient levels • response to dietary excess • diet induced thermogenesis • energy homeostasis • cell surface receptor signaling pathway • regulation of synaptic plasticity • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of appetite • regulation of cellular component size • cell volume homeostasis • cellular component organization • cellular homeostasis • intracellular water homeostasis • intracellular chemical homeostasis • cellular component organization or biogenesis • regulation of cell size • regulation of anatomical structure size • basal part of cell • basal plasma membrane • basolateral plasma membrane • polymeric cytoskeletal fiber • intracellular membraneless organelle • cytoplasmic microtubule • cytoskeleton • membraneless organelle • supramolecular fiber • microtubule • supramolecular polymer • supramolecular complex • microtubule cytoskeleton • hormone activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • digestive hormone activity • head development • central nervous system development • brain development • nervous system development • forebrain development • pallium development • telencephalon development • hippocampus development • limbic system development • digestive system process • regulation of system process • negative regulation of gastrin-induced gastric acid secretion • negative regulation of transport • negative regulation of secretion • gastrin-induced gastric acid secretion • regulation of gastrin-induced gastric acid secretion • negative regulation of digestive system process • regulation of gastric acid secretion • acid secretion • regulation of digestive system process • gastric acid secretion • digestion • negative regulation of multicellular organismal process • negative regulation of gastric acid secretion • secretion by tissue • pancreatic juice secretion • body fluid secretion • positive regulation of secretion • positive regulation of digestive system process • positive regulation of pancreatic juice secretion • regulation of pancreatic juice secretion • positive regulation of transport • digestive system development • tube development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • positive regulation of signaling • lipid catabolic process • catabolic process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • positive regulation of catabolic process • positive regulation of lipid catabolic process • positive regulation of lipid metabolic process • lipid metabolic process • positive regulation of secretion by cell • positive regulation of somatostatin secretion • somatostatin secretion • positive regulation of hormone secretion • positive regulation of peptide secretion • positive regulation of peptide hormone secretion • regulation of somatostatin secretion
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47872
Sequence	>7D3S_nogp_Chain_R S S N E K R H S Y L L K L K V M Y T V G Y S S S L V M L L V A L G I L C A F R R L H C T R N Y I H M H L F V S F I L R A L S N F I K D A V L F S S D A H R A G C K L V M V L F Q Y C I M A N Y S W L L V E G L Y L H T L L A I S F F S E R K Y L Q G F V A F G W G S P A I F V A L W A I A R H F L E D V G C W D I N A N A S I W W I I R G P V I L S I L I N F I L F I N I L R I L M R K L R T Q E V S H Y K R L A R S T L L L I P L F G I H Y I V F A F S P E D A M E I Q L F F E L A L G S F Q G L V V A V L Y C F L N G E V Q L E V Q K K W Q Q W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4

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