psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N132	R:R:S131	5.96	No	No	0	3	2
2	L:L:L13	R:R:N132	4.12	No	No	0	0	3
3	R:R:M366	R:R:R135	4.96	No	No	0	5	3
4	R:R:E367	R:R:R135	8.14	No	No	0	2	3
5	R:R:H136	R:R:L140	10.29	No	No	0	1	3
6	R:R:L142	R:R:Y138	11.72	No	No	0	6	4
7	R:R:E367	R:R:Y138	13.47	No	No	0	2	4
8	L:L:F6	R:R:L139	6.09	Yes	No	0	0	4
9	L:L:F6	R:R:L142	4.87	Yes	No	0	0	6
10	R:R:K143	R:R:Y146	7.17	No	Yes	1	5	7
11	R:R:D196	R:R:K143	6.91	No	No	1	7	5
12	L:L:F6	R:R:K143	7.44	Yes	No	1	0	5
13	R:R:Y146	R:R:Y150	5.96	Yes	Yes	1	7	7
14	R:R:N192	R:R:Y146	5.81	Yes	Yes	1	8	7
15	R:R:D196	R:R:Y146	8.05	No	Yes	1	7	7
16	L:L:F6	R:R:Y146	8.25	Yes	Yes	1	0	7
17	R:R:F379	R:R:G149	9.03	No	No	0	7	8
18	R:R:R188	R:R:Y150	10.29	Yes	Yes	1	8	7
19	R:R:A189	R:R:Y150	4	No	Yes	0	8	7
20	R:R:N192	R:R:Y150	13.96	Yes	Yes	1	8	7
21	R:R:S378	R:R:Y150	7.63	No	Yes	0	9	7
22	L:L:D3	R:R:Y150	8.05	Yes	Yes	1	0	7
23	R:R:I186	R:R:L154	4.28	No	No	0	7	6
24	R:R:L154	R:R:L190	4.15	No	No	0	6	4
25	R:R:F182	R:R:L157	8.53	Yes	No	0	8	9
26	R:R:I186	R:R:L157	4.28	No	No	0	7	9
27	R:R:A385	R:R:L157	4.73	No	No	0	8	9
28	R:R:A160	R:R:F182	4.16	No	Yes	0	9	8
29	R:R:L164	R:R:N175	6.87	No	Yes	0	8	8
30	R:R:L164	R:R:M179	5.65	No	No	0	8	6
31	R:R:E398	R:R:F167	10.49	Yes	Yes	5	8	7
32	R:R:F167	R:R:K402	11.17	Yes	No	5	7	4
33	R:R:E398	R:R:R169	9.3	Yes	No	0	8	7
34	R:R:L170	R:R:N175	4.12	No	Yes	0	9	8
35	R:R:L170	R:R:V395	5.96	No	No	0	9	9
36	R:R:E398	R:R:L170	6.63	Yes	No	0	8	9
37	R:R:T173	R:R:Y239	6.24	Yes	No	0	7	8
38	R:R:E251	R:R:T173	5.64	No	Yes	0	6	7
39	R:R:R252	R:R:T173	6.47	No	Yes	0	4	7
40	R:R:L255	R:R:T173	4.42	No	Yes	0	5	7
41	R:R:N175	R:R:R174	4.82	Yes	No	4	8	9
42	R:R:H178	R:R:R174	7.9	Yes	No	4	9	9
43	R:R:H178	R:R:N175	6.38	Yes	Yes	4	9	8
44	R:R:H180	R:R:Y176	17.42	Yes	No	0	8	6
45	R:R:L255	R:R:Y176	8.21	No	No	0	5	6
46	R:R:E236	R:R:I177	6.83	Yes	No	0	9	9
47	R:R:I177	R:R:Y239	8.46	No	No	0	9	8
48	R:R:E236	R:R:H178	9.85	Yes	Yes	0	9	9
49	R:R:H178	R:R:Y388	10.89	Yes	No	0	9	8
50	R:R:H180	R:R:W232	15.87	Yes	Yes	3	8	9
51	R:R:H180	R:R:V259	9.69	Yes	No	3	8	5
52	R:R:H180	R:R:W263	7.41	Yes	Yes	3	8	9
53	R:R:L181	R:R:S184	4.5	Yes	No	0	9	9
54	R:R:F185	R:R:L181	6.09	Yes	Yes	0	8	9
55	R:R:E236	R:R:L181	11.93	Yes	Yes	0	9	9
56	R:R:N229	R:R:S184	7.45	No	No	0	8	9
57	R:R:S184	R:R:W232	6.18	No	Yes	0	9	9
58	R:R:F185	R:R:N229	16.92	Yes	No	0	8	8
59	R:R:F185	R:R:Q380	8.2	Yes	Yes	0	8	9
60	R:R:F185	R:R:G381	9.03	Yes	No	0	8	9
61	R:R:C225	R:R:L187	4.76	No	No	0	6	6
62	R:R:I226	R:R:R188	8.77	Yes	Yes	1	6	8
63	R:R:N229	R:R:R188	12.05	No	Yes	0	8	8
64	R:R:R188	R:R:Y230	11.32	Yes	Yes	1	8	8
65	R:R:R188	R:R:Y355	4.12	Yes	Yes	1	8	8
66	L:L:D3	R:R:R188	7.15	Yes	Yes	1	0	8
67	R:R:C225	R:R:S191	6.89	No	No	0	6	5
68	R:R:F222	R:R:N192	4.83	Yes	Yes	0	6	8
69	L:L:D3	R:R:N192	14.81	Yes	Yes	1	0	8
70	R:R:D196	R:R:K195	5.53	No	No	0	7	7
71	R:R:F222	R:R:K195	12.41	Yes	No	0	6	7
72	L:L:T7	R:R:K195	10.51	No	No	0	0	7
73	R:R:V198	R:R:V218	6.41	No	No	0	4	6
74	R:R:F200	R:R:L199	8.53	Yes	No	0	4	6
75	R:R:D287	R:R:L199	9.5	Yes	No	0	6	6
76	L:L:T7	R:R:F200	5.19	No	Yes	0	0	4
77	L:L:L10	R:R:F200	15.83	No	Yes	0	0	4
78	L:L:R14	R:R:F200	8.55	No	Yes	0	0	4
79	R:R:G214	R:R:H211	4.77	No	No	0	2	7
80	R:R:C215	R:R:C285	7.28	No	No	0	9	9
81	R:R:D282	R:R:K216	9.68	No	No	7	6	8
82	R:R:K216	R:R:W286	29.01	No	Yes	7	8	9
83	R:R:D287	R:R:M219	4.16	Yes	No	0	6	6
84	R:R:F222	R:R:Q223	5.86	Yes	Yes	0	6	7
85	R:R:F222	R:R:I226	8.79	Yes	Yes	0	6	6
86	R:R:Q223	R:R:W273	9.86	Yes	No	1	7	8
87	R:R:Q223	R:R:W295	5.48	Yes	Yes	1	7	6
88	R:R:I298	R:R:Q223	9.61	Yes	Yes	1	7	7
89	L:L:H1	R:R:Q223	8.65	Yes	Yes	1	0	7
90	R:R:W263	R:R:Y224	4.82	Yes	Yes	0	9	8
91	R:R:P266	R:R:Y224	5.56	Yes	Yes	0	9	8
92	R:R:V270	R:R:Y224	5.05	No	Yes	0	7	8
93	L:L:H1	R:R:I226	17.23	Yes	Yes	1	0	6
94	L:L:D3	R:R:I226	8.4	Yes	Yes	1	0	6
95	R:R:M227	R:R:P266	5.03	No	Yes	0	6	9
96	R:R:F269	R:R:M227	4.98	No	No	0	6	6
97	R:R:I298	R:R:M227	5.83	Yes	No	0	7	6
98	R:R:V302	R:R:Y230	13.88	No	Yes	0	6	8
99	R:R:Y230	R:R:Y355	15.89	Yes	Yes	1	8	8
100	L:L:H1	R:R:Y230	4.36	Yes	Yes	1	0	8
101	R:R:P266	R:R:S231	7.13	Yes	No	0	9	5
102	R:R:V235	R:R:W232	8.58	No	Yes	0	8	9
103	R:R:V259	R:R:W232	7.36	No	Yes	3	5	9
104	R:R:G262	R:R:W232	7.04	No	Yes	0	8	9
105	R:R:W232	R:R:W263	23.43	Yes	Yes	3	9	9
106	R:R:L233	R:R:Q380	3.99	No	Yes	0	9	9
107	R:R:L234	R:R:L238	4.15	Yes	No	0	8	6
108	R:R:L234	R:R:S305	7.51	Yes	No	0	8	7
109	R:R:E236	R:R:L350	14.58	Yes	No	0	9	8
110	R:R:F351	R:R:G237	9.03	Yes	No	0	9	8
111	R:R:L238	R:R:L312	4.15	No	No	0	6	8
112	R:R:L243	R:R:Y239	8.21	No	No	0	8	8
113	R:R:L240	R:R:L244	4.15	No	No	0	9	8
114	R:R:I316	R:R:L240	7.14	No	No	0	8	9
115	R:R:F351	R:R:L240	4.87	Yes	No	0	9	9
116	R:R:A245	R:R:H241	7.32	No	Yes	0	6	8
117	R:R:H241	R:R:L312	14.14	Yes	No	0	8	8
118	R:R:H241	R:R:N315	8.93	Yes	No	0	8	7
119	R:R:H241	R:R:I316	3.98	Yes	No	0	8	8
120	R:R:I246	R:R:T242	4.56	No	No	0	4	7
121	R:R:E251	R:R:L243	3.98	No	No	0	6	8
122	R:R:E251	R:R:F249	7	No	No	0	6	6
123	R:R:F249	R:R:Y254	18.57	No	Yes	0	6	4
124	R:R:K253	R:R:S250	4.59	No	No	0	6	6
125	R:R:K253	R:R:Q256	6.78	No	No	0	6	3
126	R:R:F258	R:R:Y254	4.13	No	Yes	0	7	4
127	R:R:F261	R:R:S265	13.21	No	No	0	5	4
128	R:R:F269	R:R:P301	17.34	No	No	0	6	9
129	R:R:R277	R:R:W273	12	No	No	0	7	8
130	R:R:I298	R:R:W273	10.57	Yes	No	1	7	8
131	R:R:E281	R:R:R277	10.47	Yes	No	0	5	7
132	R:R:R277	R:R:W286	20.99	No	Yes	0	7	9
133	R:R:F279	R:R:H278	9.05	No	No	0	3	2
134	R:R:I294	R:R:L280	5.71	No	No	0	4	3
135	R:R:E281	R:R:N291	5.26	Yes	No	0	5	5
136	R:R:D282	R:R:W286	11.17	No	Yes	7	6	9
137	R:R:C285	R:R:D287	6.22	No	Yes	0	9	6
138	R:R:D287	R:R:I288	4.2	Yes	No	6	6	5
139	L:L:S11	R:R:D287	8.83	No	Yes	6	0	6
140	L:L:S11	R:R:I288	6.19	No	No	6	0	5
141	R:R:N289	R:R:W295	23.73	No	Yes	0	6	6
142	L:L:S8	R:R:N289	8.94	No	No	0	0	6
143	R:R:I294	R:R:N291	8.5	No	No	0	4	5
144	R:R:I298	R:R:W295	4.7	Yes	Yes	1	7	6
145	R:R:R299	R:R:W295	11	No	Yes	0	6	6
146	L:L:H1	R:R:W295	6.35	Yes	Yes	1	0	6
147	R:R:R299	R:R:W296	8	No	No	0	6	7
148	R:R:G300	R:R:P301	4.06	No	No	0	4	9
149	R:R:I306	R:R:Y355	6.04	No	Yes	0	7	8
150	R:R:F351	R:R:N309	12.08	Yes	No	0	9	9
151	R:R:F310	R:R:I314	6.28	No	No	0	7	4
152	R:R:F310	R:R:I356	15.07	No	No	0	7	5
153	R:R:F313	R:R:L317	7.31	Yes	No	2	9	6
154	R:R:F313	R:R:T344	5.19	Yes	No	2	9	8
155	R:R:F313	R:R:L347	7.31	Yes	No	2	9	9
156	R:R:F313	R:R:F351	5.36	Yes	Yes	2	9	9
157	R:R:F313	R:R:I353	15.07	Yes	No	0	9	5
158	R:R:N315	R:R:R318	7.23	No	No	0	7	7
159	R:R:L317	R:R:T344	7.37	No	No	2	6	8
160	R:R:R318	R:R:R322	4.26	No	No	0	7	7
161	R:R:M321	R:R:R325	6.2	No	No	0	5	6
162	R:R:L340	R:R:M321	9.9	No	No	0	8	5
163	R:R:E333	R:R:Y337	4.49	No	No	0	6	7
164	R:R:R339	R:R:R342	4.26	No	No	0	8	8
165	R:R:L346	R:R:R342	7.29	No	No	0	8	8
166	R:R:F351	R:R:L347	9.74	Yes	No	2	9	9
167	R:R:I348	R:R:P349	5.08	No	No	0	7	8
168	R:R:I348	R:R:I353	5.89	No	No	0	7	5
169	R:R:F351	R:R:L350	6.09	Yes	No	0	9	8
170	R:R:L350	R:R:Y388	24.62	No	No	0	8	8
171	R:R:H354	R:R:Y355	17.42	No	Yes	0	8	8
172	R:R:H354	R:R:Q380	12.36	No	Yes	0	8	9
173	R:R:E373	R:R:Y355	8.98	No	Yes	0	7	8
174	R:R:F358	R:R:V357	5.24	Yes	No	0	7	5
175	R:R:F358	R:R:S361	5.28	Yes	No	8	7	5
176	R:R:F358	R:R:Q369	11.71	Yes	No	8	7	7
177	R:R:F358	R:R:F372	8.57	Yes	No	0	7	5
178	R:R:A359	R:R:F360	4.16	No	No	0	6	4
179	R:R:Q369	R:R:S361	5.78	No	No	8	7	5
180	R:R:D364	R:R:P362	4.83	No	No	0	5	6
181	R:R:L370	R:R:M366	4.24	No	No	0	6	5
182	L:L:S2	R:R:L370	6.01	No	No	0	0	6
183	R:R:A375	R:R:F371	5.55	No	No	0	6	6
184	R:R:F372	R:R:L376	6.09	No	No	0	5	6
185	L:L:S2	R:R:E373	10.06	No	No	0	0	7
186	L:L:S2	R:R:L374	4.5	No	No	0	0	7
187	L:L:D3	R:R:L374	5.43	Yes	No	0	0	7
188	L:L:F6	R:R:L374	4.87	Yes	No	0	0	7
189	R:R:L387	R:R:Y388	4.69	No	No	0	7	8
190	R:R:C389	R:R:F390	5.59	No	No	0	8	8
191	R:R:E394	R:R:N392	11.83	No	No	0	9	9
192	R:R:N392	R:R:V395	5.91	No	No	0	9	9
193	R:R:E398	R:R:K402	6.75	Yes	No	5	8	4
194	R:R:Q404	R:R:W403	4.38	No	No	0	3	4
195	L:L:E9	L:L:R12	9.3	No	No	0	0	0
196	L:L:L13	L:L:R12	4.86	No	No	0	0	0
197	L:L:L19	L:L:L23	4.15	No	No	0	0	0
198	L:L:Q20	L:L:Q24	12.8	No	No	0	0	0
199	R:R:F193	R:R:S151	3.96	No	No	0	8	6
200	R:R:F222	R:R:S191	3.96	Yes	No	0	6	5
201	R:R:F379	R:R:S378	3.96	No	No	0	7	9
202	R:R:F390	R:R:V159	3.93	No	No	0	8	4
203	R:R:F167	R:R:V399	3.93	Yes	No	0	7	4
204	R:R:F390	R:R:V386	3.93	No	No	0	8	5
205	R:R:H336	R:R:L324	3.86	No	No	0	6	7
206	R:R:E373	R:R:Q369	3.82	No	No	0	7	7
207	R:R:F279	R:R:I275	3.77	No	No	0	3	4
208	R:R:F360	R:R:I303	3.77	No	No	0	4	4
209	R:R:F310	R:R:I353	3.77	No	No	0	7	5
210	R:R:A228	R:R:P266	3.74	No	Yes	0	7	9
211	R:R:G149	R:R:V148	3.68	No	No	0	8	5
212	R:R:V183	R:R:W263	3.68	No	Yes	0	4	9
213	R:R:F182	R:R:L161	3.65	Yes	No	0	8	6
214	R:R:F182	R:R:L181	3.65	Yes	Yes	0	8	9
215	R:R:F261	R:R:L234	3.65	No	Yes	0	5	8
216	L:L:L13	R:R:R135	3.64	No	No	0	0	3
217	R:R:A160	R:R:C389	3.61	No	No	0	9	8
218	R:R:P362	R:R:S361	3.56	No	No	0	6	5
219	R:R:P349	R:R:V383	3.53	No	No	0	8	6
220	R:R:G393	R:R:N392	3.39	No	No	0	4	9
221	R:R:C389	R:R:I163	3.27	No	No	0	8	8
222	R:R:A276	R:R:I294	3.25	No	No	0	4	4
223	R:R:G377	R:R:H354	3.18	No	No	0	7	8
224	L:L:G4	L:L:H1	3.18	No	Yes	0	0	0
225	R:R:C225	R:R:L221	3.17	No	No	0	6	4
226	R:R:C172	R:R:N175	3.15	No	Yes	0	8	8
227	R:R:F371	R:R:Y138	3.09	No	No	0	6	4
228	R:R:I194	R:R:V218	3.07	No	No	0	5	6
229	R:R:M156	R:R:V155	3.04	No	No	0	6	4
230	R:R:K338	R:R:V334	3.04	No	No	0	6	5
231	R:R:A290	R:R:E281	3.02	No	Yes	0	4	5
232	L:L:T5	R:R:M366	3.01	No	No	0	0	5
233	R:R:L320	R:R:S343	3	No	No	0	8	9
234	R:R:N291	R:R:S293	2.98	No	No	0	5	1
235	R:R:L382	R:R:V383	2.98	Yes	No	0	5	6
236	R:R:L382	R:R:V386	2.98	Yes	No	0	5	5
237	R:R:C215	R:R:H211	2.95	No	No	0	9	7
238	R:R:G352	R:R:Y355	2.9	No	Yes	0	9	8
239	R:R:Q380	R:R:V384	2.87	Yes	No	0	9	9
240	R:R:I186	R:R:L158	2.85	No	No	0	7	4
241	R:R:I308	R:R:L234	2.85	No	Yes	0	6	8
242	R:R:I319	R:R:L244	2.85	No	No	0	7	8
243	R:R:I297	R:R:L272	2.85	No	No	0	8	4
244	R:R:E281	R:R:V283	2.85	Yes	No	0	5	3
245	R:R:I308	R:R:L312	2.85	No	No	0	6	8
246	R:R:L382	R:R:M156	2.83	Yes	No	0	5	6
247	R:R:A166	R:R:F167	2.77	No	Yes	0	3	7
248	R:R:L320	R:R:L340	2.77	No	No	0	8	8
249	R:R:L387	R:R:L391	2.77	No	No	0	7	5
250	L:L:E15	R:R:I288	2.73	No	No	0	0	5
251	R:R:A267	R:R:Y224	2.67	No	Yes	0	3	8
252	R:R:A292	R:R:W296	2.59	No	No	0	5	7
253	R:R:R322	R:R:T326	2.59	No	No	0	7	6
254	L:L:L10	R:R:H136	2.57	No	No	0	0	1
255	R:R:S153	R:R:Y150	2.54	No	Yes	0	9	7
256	R:R:D282	R:R:H278	2.52	No	No	0	6	2
257	R:R:F358	R:R:I368	2.51	Yes	No	0	7	4
258	R:R:T242	R:R:Y254	2.5	No	Yes	0	7	4
259	R:R:E333	R:R:H336	2.46	No	No	0	6	6
260	R:R:V220	R:R:W286	2.45	No	Yes	0	6	9
261	R:R:F360	R:R:L307	2.44	No	No	0	4	3
262	R:R:L324	R:R:R339	2.43	No	No	0	7	8
263	R:R:M321	R:R:Y337	2.39	No	No	0	5	7
264	R:R:R322	R:R:R325	2.13	No	No	0	7	6
265	L:L:R18	L:L:R21	2.13	No	No	0	0	0
266	R:R:F193	R:R:Y150	2.06	No	Yes	0	8	7
267	R:R:G264	R:R:P266	2.03	No	Yes	0	7	9
268	R:R:A213	R:R:G214	1.95	No	No	0	3	2
269	R:R:A260	R:R:G257	1.95	No	No	0	1	2
270	R:R:C215	R:R:V198	1.71	No	No	0	9	4
271	L:L:G16	L:L:L19	1.71	No	No	0	0	0
272	R:R:A274	R:R:V220	1.7	No	No	0	5	6
273	R:R:G257	R:R:Q256	1.64	No	No	0	2	3
274	R:R:G393	R:R:Q396	1.64	No	No	0	4	7
275	L:L:E15	L:L:G16	1.64	No	No	0	0	0
276	L:L:G25	L:L:Q24	1.64	No	No	0	0	0
277	R:R:C165	R:R:M179	1.62	No	No	0	2	6
278	R:R:A276	R:R:I297	1.62	No	No	0	4	8
279	R:R:S335	R:R:V334	1.62	No	No	0	6	5
280	R:R:A365	R:R:I368	1.62	No	No	0	3	4
281	R:R:S151	R:R:T147	1.6	No	No	0	6	6
282	R:R:L382	R:R:S152	1.5	Yes	No	0	5	5
283	R:R:L345	R:R:T344	1.47	No	No	0	7	8
284	R:R:E133	R:R:S130	1.44	No	No	0	2	2
285	R:R:K141	R:R:M145	1.44	No	No	0	4	6
286	R:R:K401	R:R:K402	1.44	No	No	0	7	4
287	R:R:I356	R:R:L307	1.43	No	No	0	5	3
288	R:R:Q327	R:R:T326	1.42	No	No	0	5	6
289	R:R:L397	R:R:Q400	1.33	No	No	0	4	5
290	L:L:L23	L:L:Q20	1.33	No	No	0	0	0
291	R:R:Q404	R:R:Q405	1.28	No	No	0	3	6
292	R:R:S250	R:R:Y254	1.27	No	Yes	0	6	4
293	R:R:K216	R:R:R212	1.24	No	No	0	8	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y146	7.048	5	1	7
2	R:R:Y150	6.81125	8	1	7
3	R:R:F167	7.09	4	5	7
4	R:R:T173	5.6925	4	0	7
5	R:R:N175	5.068	5	4	8
6	R:R:H178	8.755	4	4	9
7	R:R:H180	12.5975	4	3	8
8	R:R:L181	6.5425	4	0	9
9	R:R:F182	4.9975	4	0	8
10	R:R:F185	10.06	4	0	8
11	R:R:R188	8.95	6	1	8
12	R:R:N192	9.8525	4	1	8
13	R:R:F200	9.525	4	0	4
14	R:R:F222	7.17	5	0	6
15	R:R:Q223	7.892	5	1	7
16	R:R:Y224	4.525	4	0	8
17	R:R:I226	10.7975	4	1	6
18	R:R:Y230	11.3625	4	1	8
19	R:R:W232	11.41	6	3	9
20	R:R:L234	4.54	4	0	8
21	R:R:E236	10.7975	4	0	9
22	R:R:H241	8.5925	4	0	8
23	R:R:Y254	6.6175	4	0	4
24	R:R:W263	9.835	4	3	9
25	R:R:P266	4.698	5	0	9
26	R:R:E281	5.4	4	0	5
27	R:R:W286	15.905	4	7	9
28	R:R:D287	6.582	5	6	6
29	R:R:W295	10.252	5	1	6
30	R:R:I298	7.6775	4	1	7
31	R:R:F313	8.048	5	2	9
32	R:R:F351	7.86167	6	2	9
33	R:R:Y355	9.225	6	1	8
34	R:R:F358	6.662	5	8	7
35	R:R:Q380	6.855	4	0	9
36	R:R:L382	2.5725	4	0	5
37	R:R:E398	8.2925	4	5	8
38	L:L:H1	7.954	5	1	0
39	L:L:D3	8.768	5	1	0
40	L:L:F6	6.304	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M366	R:R:R135	11.5354	4.96	No	No	0	5	3
2	L:L:L13	R:R:R135	10.743	3.64	No	No	0	0	3
3	L:L:T7	R:R:F200	22.9228	5.19	No	Yes	0	0	4
4	L:L:T7	R:R:K195	23.7871	10.51	No	No	0	0	7
5	R:R:L370	R:R:M366	15.7827	4.24	No	No	0	6	5
6	L:L:S2	R:R:L370	17.9042	6.01	No	No	0	0	6
7	L:L:S2	R:R:L374	10.2253	4.5	No	No	0	0	7
8	L:L:D3	R:R:L374	14.8614	5.43	Yes	No	0	0	7
9	L:L:S2	R:R:E373	10.6479	10.06	No	No	0	0	7
10	R:R:E373	R:R:Y355	22.1537	8.98	No	Yes	0	7	8
11	R:R:R188	R:R:Y355	16.6343	4.12	Yes	Yes	1	8	8
12	L:L:D3	R:R:R188	12.2919	7.15	Yes	Yes	1	0	8
13	R:R:F182	R:R:L181	20.7168	3.65	Yes	Yes	0	8	9
14	R:R:L181	R:R:S184	51.3038	4.5	Yes	No	0	9	9
15	R:R:N229	R:R:S184	52.6709	7.45	No	No	0	8	9
16	R:R:N229	R:R:R188	100	12.05	No	Yes	0	8	8
17	R:R:F185	R:R:L181	55.0503	6.09	Yes	Yes	0	8	9
18	R:R:F185	R:R:N229	48.0095	16.92	Yes	No	0	8	8
19	R:R:A160	R:R:F182	11.808	4.16	No	Yes	0	9	8
20	R:R:H178	R:R:N175	22.4347	6.38	Yes	Yes	4	9	8
21	R:R:E236	R:R:H178	25.5093	9.85	Yes	Yes	0	9	9
22	R:R:E236	R:R:L181	91.2455	11.93	Yes	Yes	0	9	9
23	R:R:L170	R:R:N175	16.3553	4.12	No	Yes	0	9	8
24	R:R:E236	R:R:I177	21.0358	6.83	Yes	No	0	9	9
25	R:R:I177	R:R:Y239	19.9772	8.46	No	No	0	9	8
26	R:R:T173	R:R:Y239	10.0287	6.24	Yes	No	0	7	8
27	R:R:S184	R:R:W232	10.4133	6.18	No	Yes	0	9	9
28	R:R:E251	R:R:T173	11.7763	5.64	No	Yes	0	6	7
29	R:R:E236	R:R:L350	58.2368	14.58	Yes	No	0	9	8
30	R:R:F222	R:R:I226	32.5649	8.79	Yes	Yes	0	6	6
31	R:R:F200	R:R:L199	18.5889	8.53	Yes	No	0	4	6
32	R:R:D287	R:R:L199	17.6993	9.5	Yes	No	0	6	6
33	R:R:R277	R:R:W286	15.7256	20.99	No	Yes	0	7	9
34	R:R:R277	R:R:W273	34.4836	12	No	No	0	7	8
35	R:R:Q223	R:R:W273	34.211	9.86	Yes	No	1	7	8
36	R:R:F222	R:R:Q223	17.2555	5.86	Yes	Yes	0	6	7
37	L:L:H1	R:R:Q223	23.9118	8.65	Yes	Yes	1	0	7
38	L:L:H1	R:R:I226	16.8054	17.23	Yes	Yes	1	0	6
39	L:L:H1	R:R:Y230	18.2592	4.36	Yes	Yes	1	0	8
40	R:R:H241	R:R:L312	13.1308	14.14	Yes	No	0	8	8
41	R:R:H241	R:R:I316	34.5723	3.98	Yes	No	0	8	8
42	R:R:I316	R:R:L240	35.6352	7.14	No	No	0	8	9
43	R:R:F351	R:R:L240	38.8408	4.87	Yes	No	0	9	9
44	R:R:F351	R:R:L350	56.876	6.09	Yes	No	0	9	8
45	R:R:H241	R:R:N315	20.0363	8.93	Yes	No	0	8	7
46	R:R:F249	R:R:Y254	16.2159	18.57	No	Yes	0	6	4
47	R:R:E251	R:R:F249	17.9782	7	No	No	0	6	6
48	R:R:E281	R:R:R277	17.452	10.47	Yes	No	0	5	7
49	R:R:E281	R:R:N291	12.2602	5.26	Yes	No	0	5	5
50	R:R:F313	R:R:I353	12.463	15.07	Yes	No	0	9	5
51	R:R:F313	R:R:F351	16.9005	5.36	Yes	Yes	2	9	9
52	R:R:N315	R:R:R318	18.8889	7.23	No	No	0	7	7
53	R:R:R318	R:R:R322	17.7373	4.26	No	No	0	7	7
54	R:R:M321	R:R:R325	13.0885	6.2	No	No	0	5	6
55	R:R:R322	R:R:R325	14.257	2.13	No	No	0	7	6
56	R:R:E373	R:R:Q369	11.4931	3.82	No	No	0	7	7
57	R:R:A160	R:R:C389	10.6796	3.61	No	No	0	9	8
58	R:R:F222	R:R:K195	22.0628	12.41	Yes	No	0	6	7
59	R:R:R188	R:R:Y150	13.8239	10.29	Yes	Yes	1	8	7
60	R:R:R188	R:R:Y230	16.3363	11.32	Yes	Yes	1	8	8
61	R:R:I226	R:R:R188	46.412	8.77	Yes	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N132	R:R:S131	5.96	0	No	No	3	2	1	2
L:L:L13	R:R:N132	4.12	0	No	No	0	3	0	1
R:R:M366	R:R:R135	4.96	0	No	No	5	3	1	1
R:R:E367	R:R:R135	8.14	0	No	No	2	3	2	1
R:R:H136	R:R:L140	10.29	0	No	No	1	3	1	2
R:R:L142	R:R:Y138	11.72	0	No	No	6	4	1	2
R:R:E367	R:R:Y138	13.47	0	No	No	2	4	2	2
L:L:F6	R:R:L139	6.09	1	Yes	No	0	4	0	1
L:L:F6	R:R:L142	4.87	1	Yes	No	0	6	0	1
R:R:K143	R:R:Y146	7.17	1	No	Yes	5	7	1	1
R:R:D196	R:R:K143	6.91	1	No	No	7	5	2	1
L:L:F6	R:R:K143	7.44	1	Yes	No	0	5	0	1
R:R:Y146	R:R:Y150	5.96	1	Yes	Yes	7	7	1	1
R:R:N192	R:R:Y146	5.81	1	Yes	Yes	8	7	1	1
R:R:D196	R:R:Y146	8.05	1	No	Yes	7	7	2	1
L:L:F6	R:R:Y146	8.25	1	Yes	Yes	0	7	0	1
R:R:R188	R:R:Y150	10.29	1	Yes	Yes	8	7	1	1
R:R:A189	R:R:Y150	4	0	No	Yes	8	7	2	1
R:R:N192	R:R:Y150	13.96	1	Yes	Yes	8	7	1	1
R:R:S378	R:R:Y150	7.63	0	No	Yes	9	7	2	1
L:L:D3	R:R:Y150	8.05	1	Yes	Yes	0	7	0	1
R:R:I226	R:R:R188	8.77	1	Yes	Yes	6	8	1	1
R:R:N229	R:R:R188	12.05	0	No	Yes	8	8	2	1
R:R:R188	R:R:Y230	11.32	1	Yes	Yes	8	8	1	1
R:R:R188	R:R:Y355	4.12	1	Yes	Yes	8	8	1	2
L:L:D3	R:R:R188	7.15	1	Yes	Yes	0	8	0	1
R:R:F222	R:R:N192	4.83	0	Yes	Yes	6	8	2	1
L:L:D3	R:R:N192	14.81	1	Yes	Yes	0	8	0	1
R:R:D196	R:R:K195	5.53	1	No	No	7	7	2	1
R:R:F222	R:R:K195	12.41	0	Yes	No	6	7	2	1
L:L:T7	R:R:K195	10.51	0	No	No	0	7	0	1
R:R:F200	R:R:L199	8.53	0	Yes	No	4	6	1	2
R:R:D287	R:R:L199	9.5	6	Yes	No	6	6	1	2
L:L:T7	R:R:F200	5.19	0	No	Yes	0	4	0	1
L:L:L10	R:R:F200	15.83	0	No	Yes	0	4	0	1
L:L:R14	R:R:F200	8.55	0	No	Yes	0	4	0	1
R:R:D287	R:R:M219	4.16	6	Yes	No	6	6	1	2
R:R:F222	R:R:Q223	5.86	0	Yes	Yes	6	7	2	1
R:R:F222	R:R:I226	8.79	0	Yes	Yes	6	6	2	1
R:R:Q223	R:R:W273	9.86	1	Yes	No	7	8	1	2
R:R:Q223	R:R:W295	5.48	1	Yes	Yes	7	6	1	1
R:R:I298	R:R:Q223	9.61	1	Yes	Yes	7	7	2	1
L:L:H1	R:R:Q223	8.65	1	Yes	Yes	0	7	0	1
L:L:H1	R:R:I226	17.23	1	Yes	Yes	0	6	0	1
L:L:D3	R:R:I226	8.4	1	Yes	Yes	0	6	0	1
R:R:V302	R:R:Y230	13.88	0	No	Yes	6	8	2	1
R:R:Y230	R:R:Y355	15.89	1	Yes	Yes	8	8	1	2
L:L:H1	R:R:Y230	4.36	1	Yes	Yes	0	8	0	1
R:R:I298	R:R:W273	10.57	1	Yes	No	7	8	2	2
R:R:C285	R:R:D287	6.22	0	No	Yes	9	6	2	1
R:R:D287	R:R:I288	4.2	6	Yes	No	6	5	1	1
L:L:S11	R:R:D287	8.83	6	No	Yes	0	6	0	1
L:L:S11	R:R:I288	6.19	6	No	No	0	5	0	1
R:R:N289	R:R:W295	23.73	0	No	Yes	6	6	1	1
L:L:S8	R:R:N289	8.94	0	No	No	0	6	0	1
R:R:I298	R:R:W295	4.7	1	Yes	Yes	7	6	2	1
R:R:R299	R:R:W295	11	0	No	Yes	6	6	2	1
L:L:H1	R:R:W295	6.35	1	Yes	Yes	0	6	0	1
R:R:E373	R:R:Y355	8.98	0	No	Yes	7	8	1	2
R:R:L370	R:R:M366	4.24	0	No	No	6	5	1	1
L:L:S2	R:R:L370	6.01	0	No	No	0	6	0	1
L:L:S2	R:R:E373	10.06	0	No	No	0	7	0	1
L:L:S2	R:R:L374	4.5	0	No	No	0	7	0	1
L:L:D3	R:R:L374	5.43	1	Yes	No	0	7	0	1
L:L:F6	R:R:L374	4.87	1	Yes	No	0	7	0	1
R:R:E373	R:R:Q369	3.82	0	No	No	7	7	1	2
L:L:L13	R:R:R135	3.64	0	No	No	0	3	0	1
L:L:T5	R:R:M366	3.01	0	No	No	0	5	0	1
L:L:E15	R:R:I288	2.73	0	No	No	0	5	0	1
L:L:L10	R:R:H136	2.57	0	No	No	0	1	0	1
R:R:S153	R:R:Y150	2.54	0	No	Yes	9	7	2	1
R:R:F193	R:R:Y150	2.06	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7D3S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.98
Number of Linked Nodes	266
Number of Links	293
Number of Hubs	40
Number of Links mediated by Hubs	148
Number of Communities	8
Number of Nodes involved in Communities	40
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	75983
Length Of Smallest Path	3
Average Path Length	14.6441
Length of Longest Path	37
Minimum Path Strength	1.675
Average Path Strength	8.09054
Maximum Path Strength	25
Minimum Path Correlation	0.7
Average Path Correlation	0.939075
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	54.191
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.1974
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47872
Sequence	>7D3S_nogp_Chain_R S S N E K R H S Y L L K L K V M Y T V G Y S S S L V M L L V A L G I L C A F R R L H C T R N Y I H M H L F V S F I L R A L S N F I K D A V L F S S D A H R A G C K L V M V L F Q Y C I M A N Y S W L L V E G L Y L H T L L A I S F F S E R K Y L Q G F V A F G W G S P A I F V A L W A I A R H F L E D V G C W D I N A N A S I W W I I R G P V I L S I L I N F I L F I N I L R I L M R K L R T Q E V S H Y K R L A R S T L L L I P L F G I H Y I V F A F S P E D A M E I Q L F F E L A L G S F Q G L V V A V L Y C F L N G E V Q L E V Q K K W Q Q W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Secretin
UniProt	P09683
Sequence	>7D3S_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042

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