psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F55	R:R:L56	6.09	No	Yes	0	4	5
2	R:R:L56	R:R:L59	4.15	Yes	No	0	5	6
3	R:R:L59	R:R:Y60	3.52	No	No	0	6	8
4	R:R:A110	R:R:Y60	2.67	No	No	0	7	8
5	R:R:L63	R:R:M309	2.83	No	No	0	7	5
6	R:R:C312	R:R:L63	3.17	No	No	0	8	7
7	R:R:F64	R:R:L68	4.87	Yes	No	0	7	6
8	R:R:F64	R:R:P107	8.67	Yes	No	0	7	9
9	R:R:C312	R:R:L66	3.17	No	No	0	8	6
10	R:R:G67	R:R:V103	3.68	No	No	0	8	6
11	R:R:G70	R:R:P315	4.06	No	No	0	7	9
12	R:R:D99	R:R:N71	2.69	Yes	Yes	0	9	9
13	R:R:N71	R:R:T100	2.92	Yes	No	0	9	7
14	R:R:N71	R:R:P315	6.52	Yes	No	0	9	9
15	R:R:D89	R:R:L78	12.21	No	Yes	0	8	7
16	R:R:L78	R:R:L93	2.77	Yes	No	0	7	6
17	R:R:L79	R:R:R82	3.64	No	No	0	4	5
18	R:R:D89	R:R:R81	3.57	No	No	0	8	5
19	R:R:D89	R:R:L85	13.57	No	No	0	8	6
20	R:R:R161	R:R:S86	2.64	No	No	0	4	7
21	R:R:S87	R:R:T88	3.2	No	No	0	6	8
22	R:R:D148	R:R:S87	7.36	Yes	No	2	8	6
23	R:R:S87	R:R:Y160	2.54	No	Yes	2	6	5
24	R:R:I145	R:R:T88	6.08	No	No	0	9	8
25	R:R:R149	R:R:T88	3.88	No	No	0	9	8
26	R:R:H94	R:R:T90	2.74	No	No	0	9	6
27	R:R:T90	R:R:V168	3.17	No	Yes	0	6	8
28	R:R:C144	R:R:F91	2.79	No	Yes	0	7	7
29	R:R:F91	R:R:I145	13.82	Yes	No	0	7	9
30	R:R:F91	R:R:V168	3.93	Yes	Yes	2	7	8
31	R:R:F91	R:R:T171	2.59	Yes	No	2	7	5
32	R:R:C172	R:R:F91	2.79	No	Yes	0	7	7
33	R:R:L92	R:R:L95	4.15	No	No	0	8	9
34	R:R:L92	R:R:Y318	5.86	No	No	0	8	9
35	R:R:C172	R:R:H94	8.85	No	No	0	7	9
36	R:R:A98	R:R:W176	2.59	No	Yes	0	8	9
37	R:R:D99	R:R:L102	2.71	Yes	Yes	1	9	6
38	R:R:D99	R:R:N134	5.39	Yes	No	1	9	8
39	R:R:C311	R:R:D99	9.34	No	Yes	1	8	9
40	R:R:L101	R:R:T100	2.95	No	No	0	5	7
41	R:R:L101	R:R:L130	5.54	No	No	0	5	5
42	R:R:L102	R:R:T105	2.95	Yes	No	0	6	7
43	R:R:L102	R:R:N134	5.49	Yes	No	1	6	8
44	R:R:L102	R:R:Y308	9.38	Yes	Yes	0	6	6
45	R:R:C311	R:R:L102	4.76	No	Yes	1	8	6
46	R:R:C311	R:R:V103	3.42	No	No	0	8	6
47	R:R:T105	R:R:W109	4.85	No	Yes	0	7	5
48	R:R:L106	R:R:Y308	3.52	No	Yes	0	8	6
49	R:R:L108	R:R:W117	6.83	No	Yes	3	6	9
50	R:R:F119	R:R:L108	8.53	Yes	No	3	7	6
51	R:R:L108	R:R:L123	4.15	No	No	3	6	6
52	R:R:D112	R:R:W109	3.35	No	Yes	3	5	5
53	R:R:W109	R:R:W117	3.75	Yes	Yes	3	5	9
54	R:R:A127	R:R:W109	5.19	No	Yes	0	5	5
55	R:R:C203	R:R:W109	2.61	No	Yes	3	9	5
56	R:R:W109	R:R:Y308	6.75	Yes	Yes	0	5	6
57	R:R:F119	R:R:V111	3.93	Yes	No	0	7	4
58	R:R:D112	R:R:W117	7.82	No	Yes	3	5	9
59	R:R:D112	R:R:H202	2.52	No	No	0	5	3
60	R:R:N199	R:R:Q116	3.96	No	No	0	5	3
61	R:R:Q116	R:R:T201	11.34	No	No	0	3	5
62	R:R:F119	R:R:W117	3.01	Yes	Yes	3	7	9
63	R:R:C124	R:R:W117	5.22	No	Yes	3	9	9
64	R:R:A192	R:R:W117	2.59	No	Yes	0	5	9
65	R:R:C203	R:R:W117	10.45	No	Yes	3	9	9
66	R:R:F119	R:R:V118	2.62	Yes	No	0	7	3
67	R:R:F119	R:R:L123	4.87	Yes	No	3	7	6
68	R:R:C124	R:R:C203	5.46	No	No	3	9	9
69	R:R:L130	R:R:V126	2.98	No	No	0	5	5
70	R:R:A129	R:R:F187	8.32	No	No	0	5	4
71	R:R:F131	R:R:W268	6.01	Yes	Yes	1	5	9
72	R:R:F131	R:R:Y271	4.13	Yes	No	1	5	6
73	R:R:F131	R:R:S304	2.64	Yes	No	0	5	5
74	R:R:F131	R:R:Y308	4.13	Yes	Yes	0	5	6
75	R:R:D186	R:R:N132	13.46	No	No	5	4	4
76	R:R:N132	R:R:Y205	4.65	No	Yes	5	4	3
77	R:R:N132	R:R:Q219	2.64	No	No	0	4	5
78	R:R:I133	R:R:W176	3.52	No	Yes	0	6	9
79	R:R:C179	R:R:I133	4.91	No	No	0	8	6
80	R:R:I133	R:R:L180	2.85	No	No	0	6	4
81	R:R:N134	R:R:W268	3.39	No	Yes	1	8	9
82	R:R:F135	R:R:Y136	4.13	Yes	Yes	1	7	6
83	R:R:A139	R:R:F135	2.77	No	Yes	0	8	7
84	R:R:F135	R:R:G223	3.01	Yes	No	1	7	5
85	R:R:F135	R:R:F264	4.29	Yes	Yes	1	7	9
86	R:R:F135	R:R:W268	5.01	Yes	Yes	1	7	9
87	R:R:F135	R:R:H272	18.1	Yes	No	0	7	8
88	R:R:C179	R:R:Y136	2.69	No	Yes	0	8	6
89	R:R:F182	R:R:Y136	4.13	No	Yes	0	5	6
90	R:R:Q219	R:R:Y136	5.64	No	Yes	0	5	6
91	R:R:G223	R:R:Y136	2.9	No	Yes	1	5	6
92	R:R:A137	R:R:W176	2.59	No	Yes	0	7	9
93	R:R:F264	R:R:G138	3.01	Yes	No	0	9	9
94	R:R:A139	R:R:P227	3.74	No	No	0	8	9
95	R:R:L140	R:R:V175	4.47	No	No	0	6	7
96	R:R:L140	R:R:L178	2.77	No	No	0	6	4
97	R:R:L141	R:R:V175	2.98	No	No	0	8	7
98	R:R:L142	R:R:M231	2.83	No	Yes	1	8	8
99	R:R:L142	R:R:V261	7.45	No	No	1	8	8
100	R:R:F264	R:R:L142	7.31	Yes	No	1	9	8
101	R:R:I145	R:R:V257	3.07	No	No	0	9	7
102	R:R:M231	R:R:S146	4.6	Yes	No	0	8	9
103	R:R:S146	R:R:Y235	10.17	No	Yes	0	9	8
104	R:R:F147	R:R:L151	7.31	No	No	0	6	5
105	R:R:C234	R:R:F147	2.79	No	No	0	7	6
106	R:R:D148	R:R:R149	4.76	Yes	No	2	8	9
107	R:R:D148	R:R:N152	5.39	Yes	No	2	8	8
108	R:R:D148	R:R:Y160	10.34	Yes	Yes	2	8	5
109	R:R:N152	R:R:R149	9.64	No	No	2	8	9
110	R:R:V154	R:R:Y150	7.57	No	Yes	4	7	8
111	R:R:H155	R:R:Y150	6.53	No	Yes	4	6	8
112	R:R:Y150	R:R:Y233	4.96	Yes	No	4	8	4
113	R:R:C234	R:R:Y150	5.38	No	Yes	0	7	8
114	R:R:H237	R:R:Y150	5.44	No	Yes	4	4	8
115	R:R:N152	R:R:Q158	9.24	No	No	0	8	4
116	R:R:I153	R:R:I238	4.42	No	No	0	8	8
117	R:R:H155	R:R:V154	4.15	No	No	4	6	7
118	R:R:H155	R:R:T157	4.11	No	No	0	6	5
119	R:R:Q158	R:R:R161	9.35	No	No	0	4	4
120	R:R:L159	R:R:R162	7.29	No	No	0	6	4
121	R:R:G163	R:R:L159	3.42	No	No	0	6	6
122	R:R:L159	R:R:R167	3.64	No	No	0	6	4
123	R:R:R167	R:R:Y160	5.14	No	Yes	0	4	5
124	R:R:V168	R:R:Y160	6.31	Yes	Yes	2	8	5
125	R:R:G163	R:R:P164	4.06	No	No	0	6	6
126	R:R:P164	R:R:R167	11.53	No	No	0	6	4
127	R:R:A166	R:R:T169	3.36	No	No	0	4	4
128	R:R:T171	R:R:V168	3.17	No	Yes	2	5	8
129	R:R:A222	R:R:F182	2.77	No	No	0	5	5
130	R:R:A183	R:R:F187	2.77	No	No	0	7	4
131	R:R:L215	R:R:P185	4.93	No	No	0	5	7
132	R:R:D186	R:R:Y205	9.2	No	Yes	5	4	3
133	R:R:F189	R:R:I188	11.3	No	No	0	5	4
134	R:R:F189	R:R:F207	6.43	No	Yes	0	5	4
135	R:R:L190	R:R:Y205	7.03	No	Yes	0	5	3
136	R:R:N206	R:R:S191	2.98	No	No	0	4	4
137	R:R:D195	R:R:H193	10.08	No	No	0	2	3
138	R:R:H193	R:R:Q204	4.95	No	No	0	3	3
139	R:R:H194	R:R:T201	5.48	No	No	0	2	5
140	R:R:D195	R:R:R197	7.15	No	No	0	2	4
141	R:R:E196	R:R:R197	5.82	No	No	0	1	4
142	R:R:A200	R:R:H202	2.93	No	No	0	1	3
143	R:R:F207	R:R:Y205	10.32	Yes	Yes	0	4	3
144	R:R:R216	R:R:Y205	7.2	No	Yes	0	3	3
145	R:R:F207	R:R:P208	2.89	Yes	No	0	4	4
146	R:R:F207	R:R:R212	19.24	Yes	No	0	4	4
147	R:R:F207	R:R:L215	3.65	Yes	No	0	4	5
148	R:R:P208	R:R:V210	3.53	No	No	0	4	1
149	R:R:Q209	R:R:R212	17.52	No	No	0	2	4
150	R:R:I279	R:R:T213	3.04	No	No	0	5	1
151	R:R:D282	R:R:T213	2.89	No	No	0	2	1
152	R:R:Q219	R:R:R216	7.01	No	No	0	5	3
153	R:R:L220	R:R:L276	5.54	No	No	0	4	5
154	R:R:L225	R:R:V221	4.47	No	No	0	4	5
155	R:R:F224	R:R:H272	7.92	No	No	0	8	8
156	L:L:?1	R:R:F224	8.23	Yes	No	0	0	8
157	R:R:L226	R:R:P227	3.28	No	No	0	6	9
158	L:L:?1	R:R:L228	7.79	Yes	No	0	0	7
159	R:R:M231	R:R:V261	3.04	Yes	No	1	8	8
160	L:L:?1	R:R:M231	11.14	Yes	Yes	0	0	8
161	R:R:H237	R:R:Y233	9.8	No	No	4	4	4
162	R:R:V257	R:R:Y235	2.52	No	Yes	0	7	8
163	R:R:V261	R:R:Y235	5.05	No	Yes	0	8	8
164	L:L:?1	R:R:Y235	11.88	Yes	Yes	0	0	8
165	L:L:?1	R:R:L239	17.14	Yes	No	0	0	5
166	R:R:R255	R:R:V259	2.62	No	No	0	5	5
167	L:L:?1	R:R:V258	10.06	Yes	No	0	0	5
168	R:R:V260	R:R:Y318	5.05	No	No	0	8	9
169	R:R:F264	R:R:W268	10.02	Yes	Yes	1	9	9
170	R:R:F264	R:R:H310	9.05	Yes	Yes	1	9	9
171	L:L:?1	R:R:F264	2.74	Yes	Yes	0	0	9
172	L:L:?1	R:R:A265	14.19	Yes	No	0	0	5
173	R:R:C267	R:R:H310	8.85	No	Yes	0	9	9
174	R:R:W268	R:R:Y271	5.79	Yes	No	1	9	6
175	R:R:G307	R:R:W268	8.44	No	Yes	0	8	9
176	R:R:H310	R:R:W268	4.23	Yes	Yes	1	9	9
177	R:R:P270	R:R:T269	3.5	No	No	0	9	5
178	R:R:T303	R:R:Y271	9.99	Yes	No	0	7	6
179	R:R:H272	R:R:V275	2.77	No	No	0	8	5
180	R:R:A299	R:R:V274	3.39	No	No	0	5	4
181	R:R:D278	R:R:D282	7.98	No	No	0	5	2
182	R:R:A285	R:R:L280	3.15	No	No	0	1	4
183	R:R:M281	R:R:R288	8.69	No	Yes	0	3	4
184	R:R:C290	R:R:R288	2.79	No	Yes	0	8	4
185	R:R:E293	R:R:R288	5.82	No	Yes	0	1	4
186	R:R:D297	R:R:V296	2.92	No	No	0	4	4
187	R:R:S301	R:R:V298	3.23	No	No	0	4	2
188	R:R:G305	R:R:Y308	2.9	No	Yes	0	5	6
189	R:R:L313	R:R:M309	2.83	No	No	0	6	5
190	R:R:H310	R:R:N314	15.31	Yes	No	0	9	9
191	R:R:N314	R:R:Y318	8.14	No	No	0	9	9
192	R:R:F320	R:R:L317	3.65	No	No	0	7	8
193	R:R:F320	R:R:V321	6.55	No	No	0	7	7
194	R:R:F64	R:R:L106	2.44	Yes	No	0	7	8
195	R:R:F182	R:R:L218	2.44	No	No	0	5	3
196	R:R:F320	R:R:L316	2.44	No	No	0	7	6
197	R:R:I238	R:R:Y150	2.42	No	Yes	0	8	8
198	R:R:I238	R:R:Y235	2.42	No	Yes	0	8	8
199	R:R:Q204	R:R:Y205	2.25	No	Yes	0	3	3
200	R:R:C312	R:R:G67	1.96	No	No	0	8	8
201	R:R:A73	R:R:G70	1.95	No	No	0	7	7
202	R:R:A75	R:R:G72	1.95	No	No	0	7	4
203	R:R:A127	R:R:G128	1.95	No	No	0	5	6
204	R:R:P164	R:R:P165	1.95	No	No	0	6	2
205	R:R:A214	R:R:G211	1.95	No	No	0	3	4
206	R:R:A114	R:R:P57	1.87	No	No	0	5	4
207	R:R:A143	R:R:P227	1.87	No	No	0	7	9
208	R:R:G122	R:R:S121	1.86	No	No	0	1	3
209	R:R:G211	R:R:V210	1.84	No	No	0	4	1
210	R:R:G322	R:R:V323	1.84	No	No	0	8	5
211	R:R:P270	R:R:T303	1.75	No	Yes	0	9	7
212	R:R:G122	R:R:K125	1.74	No	No	0	1	7
213	R:R:G70	R:R:L69	1.71	No	No	0	7	5
214	R:R:A192	R:R:S121	1.71	No	No	0	5	3
215	R:R:C144	R:R:V175	1.71	No	No	0	7	7
216	R:R:C234	R:R:V230	1.71	No	No	0	7	7
217	R:R:A96	R:R:V74	1.7	No	No	0	9	9
218	R:R:A114	R:R:V115	1.7	No	No	0	5	4
219	L:L:?1	R:R:V262	1.68	Yes	No	0	0	5
220	R:R:L56	R:R:P57	1.64	Yes	No	0	5	4
221	R:R:L184	R:R:P185	1.64	No	No	0	4	7
222	R:R:L306	R:R:P270	1.64	No	No	0	8	9
223	R:R:E293	R:R:G291	1.64	No	No	0	1	2
224	R:R:S121	R:R:S191	1.63	No	No	0	3	4
225	R:R:S301	R:R:V302	1.62	No	No	0	4	6
226	R:R:V217	R:R:V221	1.6	No	No	0	4	5
227	R:R:V258	R:R:V259	1.6	No	No	0	5	5
228	R:R:V259	R:R:V321	1.6	No	No	0	5	7
229	R:R:T100	R:R:V97	1.59	No	No	0	7	6
230	R:R:T303	R:R:V274	1.59	Yes	No	0	7	4
231	R:R:T303	R:R:V302	1.59	Yes	No	0	7	6
232	R:R:A113	R:R:L56	1.58	No	Yes	0	5	5
233	R:R:A75	R:R:L93	1.58	No	No	0	7	6
234	R:R:A263	R:R:L317	1.58	No	No	0	6	8
235	R:R:A287	R:R:L286	1.58	No	No	0	1	1
236	R:R:A96	R:R:N71	1.56	No	Yes	0	9	9
237	R:R:I279	R:R:V217	1.54	No	No	0	5	4
238	R:R:K300	R:R:V274	1.52	No	No	0	5	4
239	R:R:F119	R:R:G120	1.51	Yes	No	0	7	8
240	R:R:L78	R:R:V74	1.49	Yes	No	0	7	9
241	R:R:L78	R:R:V77	1.49	Yes	No	0	7	7
242	R:R:L220	R:R:V275	1.49	No	No	0	4	5
243	R:R:L170	R:R:T171	1.47	No	No	0	2	5
244	R:R:L273	R:R:T269	1.47	No	No	0	6	5
245	R:R:I279	R:R:L276	1.43	No	No	0	5	5
246	R:R:G177	R:R:W176	1.41	No	Yes	0	4	9
247	R:R:A54	R:R:F55	1.39	No	No	0	4	4
248	R:R:L181	R:R:L184	1.38	No	No	0	5	4
249	R:R:A287	R:R:R292	1.38	No	No	0	1	3
250	R:R:E196	R:R:H194	1.23	No	No	0	1	2
251	R:R:F64	R:R:L65	1.22	Yes	No	0	7	5
252	R:R:F64	R:R:L104	1.22	Yes	No	0	7	5
253	R:R:L85	R:R:R82	1.21	No	No	0	6	5
254	R:R:D282	R:R:R288	1.19	No	Yes	0	2	4
255	R:R:L106	R:R:Y60	1.17	No	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L56	3.365	4	0	5
2	R:R:F64	3.684	5	0	7
3	R:R:N71	3.4225	4	0	9
4	R:R:L78	4.49	4	0	7
5	R:R:F91	5.184	5	2	7
6	R:R:D99	5.0325	4	1	9
7	R:R:L102	5.058	5	1	6
8	R:R:W109	4.41667	6	3	5
9	R:R:W117	5.66714	7	3	9
10	R:R:F119	4.07833	6	3	7
11	R:R:F131	4.2275	4	1	5
12	R:R:F135	6.21833	6	1	7
13	R:R:Y136	3.898	5	1	6
14	R:R:D148	6.9625	4	2	8
15	R:R:Y150	5.38333	6	4	8
16	R:R:Y160	6.0825	4	2	5
17	R:R:V168	4.145	4	2	8
18	R:R:W176	2.5275	4	0	9
19	R:R:Y205	6.775	6	5	3
20	R:R:F207	8.506	5	0	4
21	R:R:M231	5.4025	4	1	8
22	R:R:Y235	6.408	5	0	8
23	R:R:F264	6.07	6	1	9
24	R:R:W268	6.12714	7	1	9
25	R:R:R288	4.6225	4	0	4
26	R:R:T303	3.73	4	0	7
27	R:R:Y308	5.336	5	0	6
28	R:R:H310	9.36	4	1	9
29	L:L:?1	9.42778	9	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L56	R:R:L59	13.5955	4.15	Yes	No	0	5	6
2	R:R:L59	R:R:Y60	15.4774	3.52	No	No	0	6	8
3	R:R:L106	R:R:Y60	19.195	1.17	No	No	0	8	8
4	R:R:L106	R:R:Y308	29.7872	3.52	No	Yes	0	8	6
5	R:R:L102	R:R:Y308	11.898	9.38	Yes	Yes	0	6	6
6	R:R:C311	R:R:L102	16.1533	4.76	No	Yes	1	8	6
7	R:R:C311	R:R:V103	25.2631	3.42	No	No	0	8	6
8	R:R:G67	R:R:V103	21.6991	3.68	No	No	0	8	6
9	R:R:C312	R:R:G67	18.1197	1.96	No	No	0	8	8
10	R:R:C312	R:R:L63	10.9148	3.17	No	No	0	8	7
11	R:R:D99	R:R:L102	11.9057	2.71	Yes	Yes	1	9	6
12	R:R:D99	R:R:N71	44.0203	2.69	Yes	Yes	0	9	9
13	R:R:N71	R:R:T100	10.7074	2.92	Yes	No	0	9	7
14	R:R:D89	R:R:L78	10.4386	12.21	No	Yes	0	8	7
15	R:R:L78	R:R:V74	20.7773	1.49	Yes	No	0	7	9
16	R:R:A96	R:R:V74	22.7975	1.7	No	No	0	9	9
17	R:R:A96	R:R:N71	24.8176	1.56	No	Yes	0	9	9
18	R:R:F131	R:R:Y308	58.238	4.13	Yes	Yes	0	5	6
19	R:R:F131	R:R:W268	55.3191	6.01	Yes	Yes	1	5	9
20	R:R:F264	R:R:W268	56.1564	10.02	Yes	Yes	1	9	9
21	L:L:?1	R:R:F264	91.7889	2.74	Yes	Yes	0	0	9
22	L:L:?1	R:R:Y235	83.0248	11.88	Yes	Yes	0	0	8
23	R:R:V257	R:R:Y235	65.7808	2.52	No	Yes	0	7	8
24	R:R:I145	R:R:V257	64.4443	3.07	No	No	0	9	7
25	R:R:I145	R:R:T88	29.3341	6.08	No	No	0	9	8
26	R:R:R149	R:R:T88	10.3925	3.88	No	No	0	9	8
27	R:R:S87	R:R:T88	17.4591	3.2	No	No	0	6	8
28	R:R:S87	R:R:Y160	14.0103	2.54	No	Yes	2	6	5
29	R:R:F91	R:R:I145	34.4573	13.82	Yes	No	0	7	9
30	R:R:F91	R:R:V168	18.0736	3.93	Yes	Yes	2	7	8
31	R:R:V168	R:R:Y160	15.2469	6.31	Yes	Yes	2	8	5
32	R:R:H310	R:R:N314	12.8965	15.31	Yes	No	0	9	9
33	R:R:N314	R:R:Y318	10.2696	8.14	No	No	0	9	9
34	R:R:C179	R:R:I133	12.2974	4.91	No	No	0	8	6
35	R:R:C179	R:R:Y136	14.2945	2.69	No	Yes	0	8	6
36	R:R:F135	R:R:Y136	100	4.13	Yes	Yes	1	7	6
37	R:R:F135	R:R:W268	69.3294	5.01	Yes	Yes	1	7	9
38	R:R:L102	R:R:N134	14.5403	5.49	Yes	No	1	6	8
39	R:R:W109	R:R:Y308	40.5868	6.75	Yes	Yes	0	5	6
40	R:R:W109	R:R:W117	30.8856	3.75	Yes	Yes	3	5	9
41	R:R:F119	R:R:W117	10.8995	3.01	Yes	Yes	3	7	9
42	R:R:Q219	R:R:Y136	87.2955	5.64	No	Yes	0	5	6
43	R:R:N132	R:R:Q219	43.9281	2.64	No	No	0	4	5
44	R:R:N132	R:R:Y205	40.679	4.65	No	Yes	5	4	3
45	R:R:Q204	R:R:Y205	31.9303	2.25	No	Yes	0	3	3
46	R:R:H193	R:R:Q204	28.443	4.95	No	No	0	3	3
47	R:R:D195	R:R:H193	24.9405	10.08	No	No	0	2	3
48	R:R:D195	R:R:R197	21.4225	7.15	No	No	0	2	4
49	R:R:E196	R:R:R197	17.8892	5.82	No	No	0	1	4
50	R:R:E196	R:R:H194	14.3406	1.23	No	No	0	1	2
51	R:R:H194	R:R:T201	10.7766	5.48	No	No	0	2	5
52	R:R:Q219	R:R:R216	42.2459	7.01	No	No	0	5	3
53	R:R:R216	R:R:Y205	40.702	7.2	No	Yes	0	3	3
54	R:R:A192	R:R:W117	13.127	2.59	No	Yes	0	5	9
55	R:R:F135	R:R:H272	23.9035	18.1	Yes	No	0	7	8
56	R:R:I238	R:R:Y150	19.5791	2.42	No	Yes	0	8	8
57	R:R:I238	R:R:Y235	23.3121	2.42	No	Yes	0	8	8
58	R:R:R167	R:R:Y160	25.6395	5.14	No	Yes	0	4	5
59	R:R:L159	R:R:R167	11.0377	3.64	No	No	0	6	4
60	R:R:P164	R:R:R167	11.0377	11.53	No	No	0	6	4
61	R:R:F207	R:R:Y205	45.2723	10.32	Yes	Yes	0	4	3
62	R:R:F207	R:R:L215	14.0871	3.65	Yes	No	0	4	5
63	R:R:L215	R:R:P185	10.5615	4.93	No	No	0	5	7
64	R:R:A192	R:R:S121	10.9763	1.71	No	No	0	5	3
65	R:R:F207	R:R:P208	14.3406	2.89	Yes	No	0	4	4
66	R:R:P208	R:R:V210	10.7766	3.53	No	No	0	4	1
67	R:R:H272	R:R:V275	29.2803	2.77	No	No	0	8	5
68	R:R:L220	R:R:V275	27.3984	1.49	No	No	0	4	5
69	R:R:L220	R:R:L276	25.4935	5.54	No	No	0	4	5
70	R:R:I279	R:R:L276	23.5963	1.43	No	No	0	5	5
71	R:R:I279	R:R:T213	15.8077	3.04	No	No	0	5	1
72	R:R:D282	R:R:T213	14.0487	2.89	No	No	0	2	1
73	L:L:?1	R:R:V258	15.608	10.06	Yes	No	0	0	5
74	R:R:V258	R:R:V259	13.68	1.6	No	No	0	5	5
75	R:R:T303	R:R:Y271	22.3135	9.99	Yes	No	0	7	6
76	R:R:D282	R:R:R288	10.0469	1.19	No	Yes	0	2	4
77	R:R:C311	R:R:D99	12.6507	9.34	No	Yes	1	8	9
78	R:R:D99	R:R:N134	43.7745	5.39	Yes	No	1	9	8
79	R:R:N134	R:R:W268	58.9293	3.39	No	Yes	1	8	9
80	R:R:W268	R:R:Y271	19.3486	5.79	Yes	No	1	9	6
81	R:R:F135	R:R:F264	43.6516	4.29	Yes	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F135	R:R:F264	4.29	1	Yes	Yes	7	9	2	1
R:R:F135	R:R:W268	5.01	1	Yes	Yes	7	9	2	2
R:R:F135	R:R:H272	18.1	1	Yes	No	7	8	2	2
R:R:F264	R:R:G138	3.01	1	Yes	No	9	9	1	2
R:R:L142	R:R:M231	2.83	1	No	Yes	8	8	2	1
R:R:L142	R:R:V261	7.45	1	No	No	8	8	2	2
R:R:F264	R:R:L142	7.31	1	Yes	No	9	8	1	2
R:R:M231	R:R:S146	4.6	1	Yes	No	8	9	1	2
R:R:S146	R:R:Y235	10.17	0	No	Yes	9	8	2	1
R:R:F224	R:R:H272	7.92	0	No	No	8	8	1	2
L:L:?1	R:R:F224	8.23	0	Yes	No	0	8	0	1
L:L:?1	R:R:L228	7.79	0	Yes	No	0	7	0	1
R:R:M231	R:R:V261	3.04	1	Yes	No	8	8	1	2
L:L:?1	R:R:M231	11.14	0	Yes	Yes	0	8	0	1
R:R:V257	R:R:Y235	2.52	0	No	Yes	7	8	2	1
R:R:V261	R:R:Y235	5.05	1	No	Yes	8	8	2	1
L:L:?1	R:R:Y235	11.88	0	Yes	Yes	0	8	0	1
L:L:?1	R:R:L239	17.14	0	Yes	No	0	5	0	1
L:L:?1	R:R:V258	10.06	0	Yes	No	0	5	0	1
R:R:F264	R:R:W268	10.02	1	Yes	Yes	9	9	1	2
R:R:F264	R:R:H310	9.05	1	Yes	Yes	9	9	1	2
L:L:?1	R:R:F264	2.74	0	Yes	Yes	0	9	0	1
L:L:?1	R:R:A265	14.19	0	Yes	No	0	5	0	1
R:R:H310	R:R:W268	4.23	1	Yes	Yes	9	9	2	2
R:R:I238	R:R:Y235	2.42	0	No	Yes	8	8	2	1
L:L:?1	R:R:V262	1.68	0	Yes	No	0	5	0	1
R:R:V258	R:R:V259	1.6	0	No	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
33.33	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
33.33	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
31.25	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
31.25	Consensus	ffa3_on_allo	Other Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
29.41	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
28.57	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
27.78	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
23.53	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
23.08	Consensus	gi_gaba	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
21.43	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
21.05	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
20.00	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
19.05	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
18.75	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
17.39	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
15.79	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
15.79	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
15.38	Single	7EB2	rac-BHFF	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
15.38	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
15.38	Consensus	gabab_on	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
15.38	Consensus	gi_class-c	Other Ligand	gi_mglu gi_gaba
14.29	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
14.29	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
13.64	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
13.04	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
12.50	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
12.50	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
12.50	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
12.50	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
12.50	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.76	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
11.76	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
11.76	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
11.76	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
11.76	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
11.11	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
11.11	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
11.11	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
11.11	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
11.11	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.53	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
10.53	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
10.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
10.00	Single	7E14	PubChem 156022738	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
10.00	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
10.00	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
10.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.68	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
9.52	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
9.52	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
9.09	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
9.09	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
8.70	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
8.00	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
7.89	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
7.69	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
7.69	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.14	Single	2HPY	All-trans-retinal	2HPY-Rhodopsin-All-trans-retinal
7.14	Single	7MTB	All-trans-retinal	7MTB-Rhodopsin-All-trans-retinal-GRK1
6.67	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
6.67	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
6.67	Single	3PQR	All-trans-retinal	3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
6.67	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
6.67	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
6.67	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
6.67	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
6.67	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
6.25	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
6.25	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
6.25	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
6.25	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
6.25	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
6.25	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
6.25	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
6.25	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
6.25	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
6.25	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
6.25	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
6.25	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
6.25	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.25	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
6.25	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
6.06	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.88	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.88	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
5.88	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
5.88	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.88	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.88	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
5.88	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.88	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
5.88	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.88	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.88	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.88	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
5.88	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.71	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.71	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.56	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
5.56	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
5.56	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
5.56	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.56	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.56	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
5.56	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
5.56	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	sensory_off	Orthosteric Ligand	opsin_off
5.41	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.41	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.26	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
5.26	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
5.26	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
5.26	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
5.26	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
5.26	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.26	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.26	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
5.26	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
5.26	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
5.26	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
5.00	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
5.00	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
5.00	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
5.00	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
5.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
5.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.00	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
5.00	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.00	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
5.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
5.00	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.76	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
4.76	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
4.76	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
4.76	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
4.76	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
4.76	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
4.76	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.76	Single	7EPE	NAM563	7EPE-mGlu-NAM563
4.76	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
4.76	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
4.76	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
4.76	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.76	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
4.76	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.76	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.76	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
4.76	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
4.55	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
4.55	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.55	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.55	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
4.55	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
4.55	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
4.55	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.55	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.55	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
4.55	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
4.55	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
4.55	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
4.55	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
4.55	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
4.55	Consensus	gi_class-f	Other Ligand	gi_frizzled
4.55	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.55	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
4.35	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.35	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
4.35	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
4.35	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
4.35	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.35	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
4.35	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
4.35	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
4.17	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
4.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.00	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
4.00	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
4.00	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.85	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.85	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.85	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
3.85	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.85	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
3.70	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
3.57	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.57	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
3.45	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
3.45	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.33	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.33	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
3.33	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.33	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
3.33	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	class-d_on	Orthosteric Ligand	ste2_on
3.23	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.23	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.23	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
3.23	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
3.23	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.23	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
3.23	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.23	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
3.23	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.12	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
3.12	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
3.12	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.12	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
3.12	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
3.12	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.12	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
3.12	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
3.12	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
3.03	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.03	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.03	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
2.94	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.94	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.94	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
2.86	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.86	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.86	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.78	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
2.78	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
2.78	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.70	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.70	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
2.70	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
2.56	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.56	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.44	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.38	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf

PDB Summary
PDB	8HNN
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR3
Species	Homo Sapiens
Ligand	SCH546738
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.6
Date	2023-11-29
D.O.I.	10.1038/s41594-023-01175-5

Net Summary
I_min	2.52
Number of Linked Nodes	233
Number of Links	255
Number of Hubs	29
Number of Links mediated by Hubs	125
Number of Communities	5
Number of Nodes involved in Communities	39
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	34200
Length Of Smallest Path	3
Average Path Length	11.8817
Length of Longest Path	25
Minimum Path Strength	1.22
Average Path Strength	5.09052
Maximum Path Strength	18.38
Minimum Path Correlation	0.7
Average Path Correlation	0.91134
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	46.7455
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.9106
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	43I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	43I
Name	3-azanyl-6-chloranyl-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide
Synonyms
Identifier	3-azanyl-6-chloranyl-5-[(3~{S})-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide
Formula	C23 H31 Cl2 N7 O
Molecular Weight	492.445
SMILES	CC[C@H]1CN(CCN1C2CCN(CC2)Cc3ccc(cc3)Cl)c4c(nc(c(n4)N)C(=O)N)Cl
PubChem	11995774
Formal Charge	0
Total Atoms	64
Total Chiral Atoms	1
Total Bonds	67
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8HNN_Chain_R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V Q W V F G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R R G P P A R V T L T C L A V W G L C L L F A L P D F I F L S A H H D E R L N A T H C Q Y N F P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/&β;1/&γ;2	3.01	2023-11-29	10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/&β;1/&γ;2	2.98	2023-11-29	10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/&β;1/&γ;2	2.94	2023-11-29	10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	SCH546738	-	-	3.6	2023-11-29	10.1038/s41594-023-01175-5
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/&β;1/&γ;2	3.2	2023-11-29	10.1038/s41594-023-01175-5

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