psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F55	R:R:L56	6.09	No	Yes	0	4	5
2	R:R:L56	R:R:L59	4.15	Yes	No	0	5	6
3	R:R:L59	R:R:Y60	3.52	No	No	0	6	8
4	R:R:A110	R:R:Y60	2.67	No	No	0	7	8
5	R:R:L63	R:R:M309	2.83	No	No	0	7	5
6	R:R:C312	R:R:L63	3.17	No	No	0	8	7
7	R:R:F64	R:R:L68	4.87	Yes	No	0	7	6
8	R:R:F64	R:R:P107	8.67	Yes	No	0	7	9
9	R:R:C312	R:R:L66	3.17	No	No	0	8	6
10	R:R:G67	R:R:V103	3.68	No	No	0	8	6
11	R:R:G70	R:R:P315	4.06	No	No	0	7	9
12	R:R:D99	R:R:N71	2.69	Yes	Yes	0	9	9
13	R:R:N71	R:R:T100	2.92	Yes	No	0	9	7
14	R:R:N71	R:R:P315	6.52	Yes	No	0	9	9
15	R:R:D89	R:R:L78	12.21	No	Yes	0	8	7
16	R:R:L78	R:R:L93	2.77	Yes	No	0	7	6
17	R:R:L79	R:R:R82	3.64	No	No	0	4	5
18	R:R:D89	R:R:R81	3.57	No	No	0	8	5
19	R:R:D89	R:R:L85	13.57	No	No	0	8	6
20	R:R:R161	R:R:S86	2.64	No	No	0	4	7
21	R:R:S87	R:R:T88	3.2	No	No	0	6	8
22	R:R:D148	R:R:S87	7.36	Yes	No	2	8	6
23	R:R:S87	R:R:Y160	2.54	No	Yes	2	6	5
24	R:R:I145	R:R:T88	6.08	No	No	0	9	8
25	R:R:R149	R:R:T88	3.88	No	No	0	9	8
26	R:R:H94	R:R:T90	2.74	No	No	0	9	6
27	R:R:T90	R:R:V168	3.17	No	Yes	0	6	8
28	R:R:C144	R:R:F91	2.79	No	Yes	0	7	7
29	R:R:F91	R:R:I145	13.82	Yes	No	0	7	9
30	R:R:F91	R:R:V168	3.93	Yes	Yes	2	7	8
31	R:R:F91	R:R:T171	2.59	Yes	No	2	7	5
32	R:R:C172	R:R:F91	2.79	No	Yes	0	7	7
33	R:R:L92	R:R:L95	4.15	No	No	0	8	9
34	R:R:L92	R:R:Y318	5.86	No	No	0	8	9
35	R:R:C172	R:R:H94	8.85	No	No	0	7	9
36	R:R:A98	R:R:W176	2.59	No	Yes	0	8	9
37	R:R:D99	R:R:L102	2.71	Yes	Yes	1	9	6
38	R:R:D99	R:R:N134	5.39	Yes	No	1	9	8
39	R:R:C311	R:R:D99	9.34	No	Yes	1	8	9
40	R:R:L101	R:R:T100	2.95	No	No	0	5	7
41	R:R:L101	R:R:L130	5.54	No	No	0	5	5
42	R:R:L102	R:R:T105	2.95	Yes	No	0	6	7
43	R:R:L102	R:R:N134	5.49	Yes	No	1	6	8
44	R:R:L102	R:R:Y308	9.38	Yes	Yes	0	6	6
45	R:R:C311	R:R:L102	4.76	No	Yes	1	8	6
46	R:R:C311	R:R:V103	3.42	No	No	0	8	6
47	R:R:T105	R:R:W109	4.85	No	Yes	0	7	5
48	R:R:L106	R:R:Y308	3.52	No	Yes	0	8	6
49	R:R:L108	R:R:W117	6.83	No	Yes	3	6	9
50	R:R:F119	R:R:L108	8.53	Yes	No	3	7	6
51	R:R:L108	R:R:L123	4.15	No	No	3	6	6
52	R:R:D112	R:R:W109	3.35	No	Yes	3	5	5
53	R:R:W109	R:R:W117	3.75	Yes	Yes	3	5	9
54	R:R:A127	R:R:W109	5.19	No	Yes	0	5	5
55	R:R:C203	R:R:W109	2.61	No	Yes	3	9	5
56	R:R:W109	R:R:Y308	6.75	Yes	Yes	0	5	6
57	R:R:F119	R:R:V111	3.93	Yes	No	0	7	4
58	R:R:D112	R:R:W117	7.82	No	Yes	3	5	9
59	R:R:D112	R:R:H202	2.52	No	No	0	5	3
60	R:R:N199	R:R:Q116	3.96	No	No	0	5	3
61	R:R:Q116	R:R:T201	11.34	No	No	0	3	5
62	R:R:F119	R:R:W117	3.01	Yes	Yes	3	7	9
63	R:R:C124	R:R:W117	5.22	No	Yes	3	9	9
64	R:R:A192	R:R:W117	2.59	No	Yes	0	5	9
65	R:R:C203	R:R:W117	10.45	No	Yes	3	9	9
66	R:R:F119	R:R:V118	2.62	Yes	No	0	7	3
67	R:R:F119	R:R:L123	4.87	Yes	No	3	7	6
68	R:R:C124	R:R:C203	5.46	No	No	3	9	9
69	R:R:L130	R:R:V126	2.98	No	No	0	5	5
70	R:R:A129	R:R:F187	8.32	No	No	0	5	4
71	R:R:F131	R:R:W268	6.01	Yes	Yes	1	5	9
72	R:R:F131	R:R:Y271	4.13	Yes	No	1	5	6
73	R:R:F131	R:R:S304	2.64	Yes	No	0	5	5
74	R:R:F131	R:R:Y308	4.13	Yes	Yes	0	5	6
75	R:R:D186	R:R:N132	13.46	No	No	5	4	4
76	R:R:N132	R:R:Y205	4.65	No	Yes	5	4	3
77	R:R:N132	R:R:Q219	2.64	No	No	0	4	5
78	R:R:I133	R:R:W176	3.52	No	Yes	0	6	9
79	R:R:C179	R:R:I133	4.91	No	No	0	8	6
80	R:R:I133	R:R:L180	2.85	No	No	0	6	4
81	R:R:N134	R:R:W268	3.39	No	Yes	1	8	9
82	R:R:F135	R:R:Y136	4.13	Yes	Yes	1	7	6
83	R:R:A139	R:R:F135	2.77	No	Yes	0	8	7
84	R:R:F135	R:R:G223	3.01	Yes	No	1	7	5
85	R:R:F135	R:R:F264	4.29	Yes	Yes	1	7	9
86	R:R:F135	R:R:W268	5.01	Yes	Yes	1	7	9
87	R:R:F135	R:R:H272	18.1	Yes	No	0	7	8
88	R:R:C179	R:R:Y136	2.69	No	Yes	0	8	6
89	R:R:F182	R:R:Y136	4.13	No	Yes	0	5	6
90	R:R:Q219	R:R:Y136	5.64	No	Yes	0	5	6
91	R:R:G223	R:R:Y136	2.9	No	Yes	1	5	6
92	R:R:A137	R:R:W176	2.59	No	Yes	0	7	9
93	R:R:F264	R:R:G138	3.01	Yes	No	0	9	9
94	R:R:A139	R:R:P227	3.74	No	No	0	8	9
95	R:R:L140	R:R:V175	4.47	No	No	0	6	7
96	R:R:L140	R:R:L178	2.77	No	No	0	6	4
97	R:R:L141	R:R:V175	2.98	No	No	0	8	7
98	R:R:L142	R:R:M231	2.83	No	Yes	1	8	8
99	R:R:L142	R:R:V261	7.45	No	Yes	1	8	8
100	R:R:F264	R:R:L142	7.31	Yes	No	1	9	8
101	R:R:I145	R:R:V257	3.07	No	No	0	9	7
102	R:R:M231	R:R:S146	4.6	Yes	No	0	8	9
103	R:R:S146	R:R:Y235	10.17	No	Yes	0	9	8
104	R:R:F147	R:R:L151	7.31	No	No	0	6	5
105	R:R:C234	R:R:F147	2.79	No	No	0	7	6
106	R:R:D148	R:R:R149	4.76	Yes	No	2	8	9
107	R:R:D148	R:R:N152	5.39	Yes	No	2	8	8
108	R:R:D148	R:R:Y160	10.34	Yes	Yes	2	8	5
109	R:R:N152	R:R:R149	9.64	No	No	2	8	9
110	R:R:V154	R:R:Y150	7.57	No	Yes	4	7	8
111	R:R:H155	R:R:Y150	6.53	No	Yes	4	6	8
112	R:R:Y150	R:R:Y233	4.96	Yes	No	4	8	4
113	R:R:C234	R:R:Y150	5.38	No	Yes	0	7	8
114	R:R:H237	R:R:Y150	5.44	No	Yes	4	4	8
115	R:R:N152	R:R:Q158	9.24	No	No	0	8	4
116	R:R:I153	R:R:I238	4.42	No	No	0	8	8
117	R:R:H155	R:R:V154	4.15	No	No	4	6	7
118	R:R:H155	R:R:T157	4.11	No	No	0	6	5
119	R:R:Q158	R:R:R161	9.35	No	No	0	4	4
120	R:R:L159	R:R:R162	7.29	No	No	0	6	4
121	R:R:G163	R:R:L159	3.42	No	No	0	6	6
122	R:R:L159	R:R:R167	3.64	No	No	0	6	4
123	R:R:R167	R:R:Y160	5.14	No	Yes	0	4	5
124	R:R:V168	R:R:Y160	6.31	Yes	Yes	2	8	5
125	R:R:G163	R:R:P164	4.06	No	No	0	6	6
126	R:R:P164	R:R:R167	11.53	No	No	0	6	4
127	R:R:A166	R:R:T169	3.36	No	No	0	4	4
128	R:R:T171	R:R:V168	3.17	No	Yes	2	5	8
129	R:R:A222	R:R:F182	2.77	No	No	0	5	5
130	R:R:A183	R:R:F187	2.77	No	No	0	7	4
131	R:R:L215	R:R:P185	4.93	No	No	0	5	7
132	R:R:D186	R:R:Y205	9.2	No	Yes	5	4	3
133	R:R:F189	R:R:I188	11.3	No	No	0	5	4
134	R:R:F189	R:R:F207	6.43	No	Yes	0	5	4
135	R:R:L190	R:R:Y205	7.03	No	Yes	0	5	3
136	R:R:N206	R:R:S191	2.98	No	No	0	4	4
137	R:R:D195	R:R:H193	10.08	No	No	0	2	3
138	R:R:H193	R:R:Q204	4.95	No	No	0	3	3
139	R:R:H194	R:R:T201	5.48	No	No	0	2	5
140	R:R:D195	R:R:R197	7.15	No	No	0	2	4
141	R:R:E196	R:R:R197	5.82	No	No	0	1	4
142	R:R:A200	R:R:H202	2.93	No	No	0	1	3
143	R:R:F207	R:R:Y205	10.32	Yes	Yes	0	4	3
144	R:R:R216	R:R:Y205	7.2	No	Yes	0	3	3
145	R:R:F207	R:R:P208	2.89	Yes	No	0	4	4
146	R:R:F207	R:R:R212	19.24	Yes	No	0	4	4
147	R:R:F207	R:R:L215	3.65	Yes	No	0	4	5
148	R:R:P208	R:R:V210	3.53	No	No	0	4	1
149	R:R:Q209	R:R:R212	17.52	No	No	0	2	4
150	R:R:I279	R:R:T213	3.04	No	No	0	5	1
151	R:R:D282	R:R:T213	2.89	No	No	0	2	1
152	R:R:Q219	R:R:R216	7.01	No	No	0	5	3
153	R:R:L220	R:R:L276	5.54	No	No	0	4	5
154	R:R:L225	R:R:V221	4.47	No	No	0	4	5
155	R:R:F224	R:R:H272	7.92	No	No	0	8	8
156	L:L:?1	R:R:F224	7.65	Yes	No	0	0	8
157	R:R:L226	R:R:P227	3.28	No	No	0	6	9
158	L:L:?1	R:R:L228	7.24	Yes	No	0	0	7
159	R:R:M231	R:R:V261	3.04	Yes	Yes	1	8	8
160	L:L:?1	R:R:M231	10.35	Yes	Yes	0	0	8
161	R:R:H237	R:R:Y233	9.8	No	No	4	4	4
162	R:R:V257	R:R:Y235	2.52	No	Yes	0	7	8
163	R:R:V261	R:R:Y235	5.05	Yes	Yes	0	8	8
164	L:L:?1	R:R:Y235	11.04	Yes	Yes	0	0	8
165	L:L:?1	R:R:L239	15.93	Yes	No	0	0	5
166	R:R:R255	R:R:V259	2.62	No	No	0	5	5
167	L:L:?1	R:R:V258	9.35	Yes	No	0	0	5
168	R:R:V260	R:R:Y318	5.05	No	No	0	8	9
169	R:R:F264	R:R:W268	10.02	Yes	Yes	1	9	9
170	R:R:F264	R:R:H310	9.05	Yes	Yes	1	9	9
171	L:L:?1	R:R:F264	2.55	Yes	Yes	0	0	9
172	L:L:?1	R:R:A265	13.19	Yes	No	0	0	5
173	R:R:C267	R:R:H310	8.85	No	Yes	0	9	9
174	R:R:W268	R:R:Y271	5.79	Yes	No	1	9	6
175	R:R:G307	R:R:W268	8.44	No	Yes	0	8	9
176	R:R:H310	R:R:W268	4.23	Yes	Yes	1	9	9
177	R:R:P270	R:R:T269	3.5	No	No	0	9	5
178	R:R:T303	R:R:Y271	9.99	Yes	No	0	7	6
179	R:R:H272	R:R:V275	2.77	No	No	0	8	5
180	R:R:A299	R:R:V274	3.39	No	No	0	5	4
181	R:R:D278	R:R:D282	7.98	No	No	0	5	2
182	R:R:A285	R:R:L280	3.15	No	No	0	1	4
183	R:R:M281	R:R:R288	8.69	No	Yes	0	3	4
184	R:R:C290	R:R:R288	2.79	No	Yes	0	8	4
185	R:R:E293	R:R:R288	5.82	No	Yes	0	1	4
186	R:R:D297	R:R:V296	2.92	No	No	0	4	4
187	R:R:S301	R:R:V298	3.23	No	No	0	4	2
188	R:R:G305	R:R:Y308	2.9	No	Yes	0	5	6
189	R:R:L313	R:R:M309	2.83	No	No	0	6	5
190	R:R:H310	R:R:N314	15.31	Yes	No	0	9	9
191	R:R:N314	R:R:Y318	8.14	No	No	0	9	9
192	R:R:F320	R:R:L317	3.65	No	No	0	7	8
193	R:R:F320	R:R:V321	6.55	No	No	0	7	7
194	R:R:F64	R:R:L106	2.44	Yes	No	0	7	8
195	R:R:F182	R:R:L218	2.44	No	No	0	5	3
196	R:R:F320	R:R:L316	2.44	No	No	0	7	6
197	R:R:I238	R:R:Y150	2.42	No	Yes	0	8	8
198	R:R:I238	R:R:Y235	2.42	No	Yes	0	8	8
199	R:R:Q204	R:R:Y205	2.25	No	Yes	0	3	3
200	R:R:C312	R:R:G67	1.96	No	No	0	8	8
201	R:R:A73	R:R:G70	1.95	No	No	0	7	7
202	R:R:A75	R:R:G72	1.95	No	No	0	7	4
203	R:R:A127	R:R:G128	1.95	No	No	0	5	6
204	R:R:P164	R:R:P165	1.95	No	No	0	6	2
205	R:R:A214	R:R:G211	1.95	No	No	0	3	4
206	R:R:A114	R:R:P57	1.87	No	No	0	5	4
207	R:R:A143	R:R:P227	1.87	No	No	0	7	9
208	R:R:G122	R:R:S121	1.86	No	No	0	1	3
209	R:R:G211	R:R:V210	1.84	No	No	0	4	1
210	R:R:G322	R:R:V323	1.84	No	No	0	8	5
211	R:R:P270	R:R:T303	1.75	No	Yes	0	9	7
212	R:R:G122	R:R:K125	1.74	No	No	0	1	7
213	R:R:G70	R:R:L69	1.71	No	No	0	7	5
214	R:R:A192	R:R:S121	1.71	No	No	0	5	3
215	R:R:C144	R:R:V175	1.71	No	No	0	7	7
216	R:R:C234	R:R:V230	1.71	No	No	0	7	7
217	R:R:A96	R:R:V74	1.7	No	No	0	9	9
218	R:R:A114	R:R:V115	1.7	No	No	0	5	4
219	R:R:L56	R:R:P57	1.64	Yes	No	0	5	4
220	R:R:L184	R:R:P185	1.64	No	No	0	4	7
221	R:R:L306	R:R:P270	1.64	No	No	0	8	9
222	R:R:E293	R:R:G291	1.64	No	No	0	1	2
223	R:R:S121	R:R:S191	1.63	No	No	0	3	4
224	R:R:S301	R:R:V302	1.62	No	No	0	4	6
225	R:R:V217	R:R:V221	1.6	No	No	0	4	5
226	R:R:V258	R:R:V259	1.6	No	No	0	5	5
227	R:R:V258	R:R:V262	1.6	No	No	0	5	5
228	R:R:V259	R:R:V321	1.6	No	No	0	5	7
229	R:R:V261	R:R:V262	1.6	Yes	No	0	8	5
230	R:R:T100	R:R:V97	1.59	No	No	0	7	6
231	R:R:T303	R:R:V274	1.59	Yes	No	0	7	4
232	R:R:T303	R:R:V302	1.59	Yes	No	0	7	6
233	R:R:A113	R:R:L56	1.58	No	Yes	0	5	5
234	R:R:A75	R:R:L93	1.58	No	No	0	7	6
235	R:R:A263	R:R:L317	1.58	No	No	0	6	8
236	R:R:A287	R:R:L286	1.58	No	No	0	1	1
237	R:R:A96	R:R:N71	1.56	No	Yes	0	9	9
238	R:R:I279	R:R:V217	1.54	No	No	0	5	4
239	R:R:K300	R:R:V274	1.52	No	No	0	5	4
240	R:R:F119	R:R:G120	1.51	Yes	No	0	7	8
241	R:R:L78	R:R:V74	1.49	Yes	No	0	7	9
242	R:R:L78	R:R:V77	1.49	Yes	No	0	7	7
243	R:R:L220	R:R:V275	1.49	No	No	0	4	5
244	R:R:L170	R:R:T171	1.47	No	No	0	2	5
245	R:R:L273	R:R:T269	1.47	No	No	0	6	5
246	R:R:I279	R:R:L276	1.43	No	No	0	5	5
247	R:R:G177	R:R:W176	1.41	No	Yes	0	4	9
248	R:R:A54	R:R:F55	1.39	No	No	0	4	4
249	R:R:L181	R:R:L184	1.38	No	No	0	5	4
250	R:R:A287	R:R:R292	1.38	No	No	0	1	3
251	R:R:E196	R:R:H194	1.23	No	No	0	1	2
252	R:R:F64	R:R:L65	1.22	Yes	No	0	7	5
253	R:R:F64	R:R:L104	1.22	Yes	No	0	7	5
254	R:R:L85	R:R:R82	1.21	No	No	0	6	5
255	R:R:D282	R:R:R288	1.19	No	Yes	0	2	4
256	R:R:L106	R:R:Y60	1.17	No	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L56	3.365	4	0	5
2	R:R:F64	3.684	5	0	7
3	R:R:N71	3.4225	4	0	9
4	R:R:L78	4.49	4	0	7
5	R:R:F91	5.184	5	2	7
6	R:R:D99	5.0325	4	1	9
7	R:R:L102	5.058	5	1	6
8	R:R:W109	4.41667	6	3	5
9	R:R:W117	5.66714	7	3	9
10	R:R:F119	4.07833	6	3	7
11	R:R:F131	4.2275	4	1	5
12	R:R:F135	6.21833	6	1	7
13	R:R:Y136	3.898	5	1	6
14	R:R:D148	6.9625	4	2	8
15	R:R:Y150	5.38333	6	4	8
16	R:R:Y160	6.0825	4	2	5
17	R:R:V168	4.145	4	2	8
18	R:R:W176	2.5275	4	0	9
19	R:R:Y205	6.775	6	5	3
20	R:R:F207	8.506	5	0	4
21	R:R:M231	5.205	4	1	8
22	R:R:Y235	6.24	5	0	8
23	R:R:V261	4.285	4	1	8
24	R:R:F264	6.03833	6	1	9
25	R:R:W268	6.12714	7	1	9
26	R:R:R288	4.6225	4	0	4
27	R:R:T303	3.73	4	0	7
28	R:R:Y308	5.336	5	0	6
29	R:R:H310	9.36	4	1	9
30	L:L:?1	9.6625	8	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L56	R:R:L59	13.5835	4.15	Yes	No	0	5	6
2	R:R:L59	R:R:Y60	15.464	3.52	No	No	0	6	8
3	R:R:L106	R:R:Y60	19.179	1.17	No	No	0	8	8
4	R:R:L106	R:R:Y308	29.7661	3.52	No	Yes	0	8	6
5	R:R:L102	R:R:Y308	11.8407	9.38	Yes	Yes	0	6	6
6	R:R:C311	R:R:L102	16.1367	4.76	No	Yes	1	8	6
7	R:R:C311	R:R:V103	25.2484	3.42	No	No	0	8	6
8	R:R:G67	R:R:V103	21.6863	3.68	No	No	0	8	6
9	R:R:C312	R:R:G67	18.1089	1.96	No	No	0	8	8
10	R:R:C312	R:R:L63	10.9081	3.17	No	No	0	8	7
11	R:R:D99	R:R:L102	11.8483	2.71	Yes	Yes	1	9	6
12	R:R:D99	R:R:N71	43.9765	2.69	Yes	Yes	0	9	9
13	R:R:N71	R:R:T100	10.6941	2.92	Yes	No	0	9	7
14	R:R:D89	R:R:L78	10.4265	12.21	No	Yes	0	8	7
15	R:R:L78	R:R:V74	20.7537	1.49	Yes	No	0	7	9
16	R:R:A96	R:R:V74	22.7717	1.7	No	No	0	9	9
17	R:R:A96	R:R:N71	24.7898	1.56	No	Yes	0	9	9
18	R:R:F131	R:R:Y308	58.2709	4.13	Yes	Yes	0	5	6
19	R:R:F131	R:R:W268	55.3814	6.01	Yes	Yes	1	5	9
20	R:R:F264	R:R:W268	56.6427	10.02	Yes	Yes	1	9	9
21	L:L:?1	R:R:F264	91.3392	2.55	Yes	Yes	0	0	9
22	L:L:?1	R:R:Y235	82.151	11.04	Yes	Yes	0	0	8
23	R:R:V257	R:R:Y235	65.464	2.52	No	Yes	0	7	8
24	R:R:I145	R:R:V257	64.1339	3.07	No	No	0	9	7
25	R:R:I145	R:R:T88	29.1928	6.08	No	No	0	9	8
26	R:R:R149	R:R:T88	10.3425	3.88	No	No	0	9	8
27	R:R:S87	R:R:T88	17.375	3.2	No	No	0	6	8
28	R:R:S87	R:R:Y160	13.9428	2.54	No	Yes	2	6	5
29	R:R:F91	R:R:I145	34.2914	13.82	Yes	No	0	7	9
30	R:R:F91	R:R:V168	17.9865	3.93	Yes	Yes	2	7	8
31	R:R:V168	R:R:Y160	15.1735	6.31	Yes	Yes	2	8	5
32	R:R:H310	R:R:N314	12.8727	15.31	Yes	No	0	9	9
33	R:R:N314	R:R:Y318	10.2507	8.14	No	No	0	9	9
34	R:R:C179	R:R:I133	12.2841	4.91	No	No	0	8	6
35	R:R:C179	R:R:Y136	14.2792	2.69	No	Yes	0	8	6
36	R:R:F135	R:R:Y136	100	4.13	Yes	Yes	1	7	6
37	R:R:F135	R:R:W268	68.9956	5.01	Yes	Yes	1	7	9
38	R:R:L102	R:R:N134	14.5467	5.49	Yes	No	1	6	8
39	R:R:W109	R:R:Y308	40.5672	6.75	Yes	Yes	0	5	6
40	R:R:W109	R:R:W117	30.8516	3.75	Yes	Yes	3	5	9
41	R:R:F119	R:R:W117	10.8852	3.01	Yes	Yes	3	7	9
42	R:R:Q219	R:R:Y136	87.2726	5.64	No	Yes	0	5	6
43	R:R:N132	R:R:Q219	43.9153	2.64	No	No	0	4	5
44	R:R:N132	R:R:Y205	40.6666	4.65	No	Yes	5	4	3
45	R:R:Q204	R:R:Y205	31.9141	2.25	No	Yes	0	3	3
46	R:R:H193	R:R:Q204	28.4284	4.95	No	No	0	3	3
47	R:R:D195	R:R:H193	24.9274	10.08	No	No	0	2	3
48	R:R:D195	R:R:R197	21.4111	7.15	No	No	0	2	4
49	R:R:E196	R:R:R197	17.8795	5.82	No	No	0	1	4
50	R:R:E196	R:R:H194	14.3327	1.23	No	No	0	1	2
51	R:R:H194	R:R:T201	10.7705	5.48	No	No	0	2	5
52	R:R:Q219	R:R:R216	42.2336	7.01	No	No	0	5	3
53	R:R:R216	R:R:Y205	40.6895	7.2	No	Yes	0	3	3
54	R:R:A192	R:R:W117	13.1096	2.59	No	Yes	0	5	9
55	R:R:F135	R:R:H272	23.7884	18.1	Yes	No	0	7	8
56	R:R:I238	R:R:Y150	19.4848	2.42	No	Yes	0	8	8
57	R:R:I238	R:R:Y235	23.1998	2.42	No	Yes	0	8	8
58	R:R:R167	R:R:Y160	25.516	5.14	No	Yes	0	4	5
59	R:R:L159	R:R:R167	10.9846	3.64	No	No	0	6	4
60	R:R:P164	R:R:R167	10.9846	11.53	No	No	0	6	4
61	R:R:F207	R:R:Y205	45.253	10.32	Yes	Yes	0	4	3
62	R:R:F207	R:R:L215	14.0804	3.65	Yes	No	0	4	5
63	R:R:L215	R:R:P185	10.5565	4.93	No	No	0	5	7
64	R:R:A192	R:R:S121	10.9616	1.71	No	No	0	5	3
65	R:R:F207	R:R:P208	14.3327	2.89	Yes	No	0	4	4
66	R:R:P208	R:R:V210	10.7705	3.53	No	No	0	4	1
67	R:R:H272	R:R:V275	29.1393	2.77	No	No	0	8	5
68	R:R:L220	R:R:V275	27.2665	1.49	No	No	0	4	5
69	R:R:L220	R:R:L276	25.3707	5.54	No	No	0	4	5
70	R:R:I279	R:R:L276	23.4826	1.43	No	No	0	5	5
71	R:R:I279	R:R:T213	15.7315	3.04	No	No	0	5	1
72	R:R:D282	R:R:T213	13.981	2.89	No	No	0	2	1
73	L:L:?1	R:R:V258	16.8629	9.35	Yes	No	0	0	5
74	R:R:V258	R:R:V259	13.6141	1.6	No	No	0	5	5
75	R:R:T303	R:R:Y271	22.2902	9.99	Yes	No	0	7	6
76	R:R:C311	R:R:D99	12.651	9.34	No	Yes	1	8	9
77	R:R:D99	R:R:N134	43.8006	5.39	Yes	No	1	9	8
78	R:R:N134	R:R:W268	58.9665	3.39	No	Yes	1	8	9
79	R:R:W268	R:R:Y271	19.3472	5.79	Yes	No	1	9	6
80	R:R:F135	R:R:F264	43.9688	4.29	Yes	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F135	R:R:F264	4.29	1	Yes	Yes	7	9	2	1
R:R:F135	R:R:W268	5.01	1	Yes	Yes	7	9	2	2
R:R:F135	R:R:H272	18.1	1	Yes	No	7	8	2	2
R:R:F264	R:R:G138	3.01	1	Yes	No	9	9	1	2
R:R:L142	R:R:M231	2.83	1	No	Yes	8	8	2	1
R:R:L142	R:R:V261	7.45	1	No	Yes	8	8	2	2
R:R:F264	R:R:L142	7.31	1	Yes	No	9	8	1	2
R:R:M231	R:R:S146	4.6	1	Yes	No	8	9	1	2
R:R:S146	R:R:Y235	10.17	0	No	Yes	9	8	2	1
R:R:F224	R:R:H272	7.92	0	No	No	8	8	1	2
L:L:?1	R:R:F224	7.65	0	Yes	No	0	8	0	1
L:L:?1	R:R:L228	7.24	0	Yes	No	0	7	0	1
R:R:M231	R:R:V261	3.04	1	Yes	Yes	8	8	1	2
L:L:?1	R:R:M231	10.35	0	Yes	Yes	0	8	0	1
R:R:V257	R:R:Y235	2.52	0	No	Yes	7	8	2	1
R:R:V261	R:R:Y235	5.05	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:Y235	11.04	0	Yes	Yes	0	8	0	1
L:L:?1	R:R:L239	15.93	0	Yes	No	0	5	0	1
L:L:?1	R:R:V258	9.35	0	Yes	No	0	5	0	1
R:R:F264	R:R:W268	10.02	1	Yes	Yes	9	9	1	2
R:R:F264	R:R:H310	9.05	1	Yes	Yes	9	9	1	2
L:L:?1	R:R:F264	2.55	0	Yes	Yes	0	9	0	1
L:L:?1	R:R:A265	13.19	0	Yes	No	0	5	0	1
R:R:H310	R:R:W268	4.23	1	Yes	Yes	9	9	2	2
R:R:I238	R:R:Y235	2.42	0	No	Yes	8	8	2	1
R:R:V258	R:R:V259	1.6	0	No	No	5	5	1	2
R:R:V258	R:R:V262	1.6	0	No	No	5	5	1	2
R:R:V261	R:R:V262	1.6	1	Yes	No	8	5	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
35.71	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
35.71	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
33.33	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
30.77	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
29.41	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
25.00	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
23.53	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
21.43	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
20.00	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
20.00	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
20.00	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
20.00	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.75	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.67	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
16.67	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
15.38	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
15.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
14.29	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
13.33	Single	7C7Q	BHFF	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
13.33	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
13.33	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
13.33	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
13.33	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
13.33	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
13.33	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.50	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
12.50	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
12.50	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
12.50	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.50	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
11.76	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
11.76	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
11.76	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
11.76	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
11.11	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
11.11	Single	7E14	PubChem 156022738	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
11.11	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.53	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
10.00	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
10.00	Single	8JD3	JNJ-40411813	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
10.00	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
9.52	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
9.52	Single	6LN2	PF-06372222	6LN2-GLP-1-PF-06372222
9.52	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
9.09	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
9.09	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69	Single	2HPY	All-trans-Retinal	2HPY-Rhodopsin-All-trans-Retinal
7.69	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
7.69	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
7.69	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
7.69	Single	8Y02	Retinal	8Y02-OPN1SW-Retinal-Gi1/β1/γ2
7.69	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
7.14	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
7.14	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
7.14	Single	3PQR	All-trans-Retinal	3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
7.14	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
7.14	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
7.14	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
7.14	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.14	Single	8Y6W	4-CMTB	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
7.14	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
7.14	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.67	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
6.67	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
6.67	Single	2G87	All-trans-Retinal	2G87-Rhodopsin-All-trans-Retinal
6.67	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
6.67	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
6.67	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
6.67	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
6.67	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
6.67	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
6.67	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
6.67	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-LY2119620-Gi1/β1/γ2
6.67	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.67	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.67	Single	9EPR	Retinal	9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
6.25	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
6.25	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
6.25	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
6.25	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
6.25	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
6.25	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
6.25	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2
6.25	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.25	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.25	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.25	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.25	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.25	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.25	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25	Single	9CLW	4-CMTB	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
6.25	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
6.25	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
5.88	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.88	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
5.88	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
5.88	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
5.88	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.88	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.88	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
5.88	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
5.88	Single	8Y01	Retinal	8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
5.88	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
5.88	Consensus	sensory_off	Orthosteric Ligand	opsins_off
5.56	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
5.56	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
5.56	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
5.56	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
5.56	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
5.56	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
5.56	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
5.56	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
5.56	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
5.56	Single	7RBT	LSN3556672	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8JD0	NAM563	8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.56	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.26	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
5.26	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
5.26	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.26	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
5.26	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.26	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
5.26	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.26	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.26	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8GW8	PCO371	8GW8-PTH1-PCO371-Gs/β1/γ2
5.26	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.26	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
5.26	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
5.26	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
5.26	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.26	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
5.26	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
5.26	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
5.26	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
5.26	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.26	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.00	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
5.00	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
5.00	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
5.00	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
5.00	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
5.00	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.00	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.00	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/β1/γ2
5.00	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.00	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
5.00	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
5.00	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
5.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.00	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.00	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
4.76	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
4.76	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.76	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.76	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.76	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
4.76	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
4.76	Single	7EPE	NAM563	7EPE-mGlu2; mGlu2-NAM563
4.76	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
4.76	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
4.76	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
4.76	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
4.76	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.76	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
4.76	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
4.76	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.76	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.76	Single	8ZYU	SBI-553	8ZYU-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
4.76	Single	8ZYY	SBI-553	8ZYY-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
4.76	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.76	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.76	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.55	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.55	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
4.55	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
4.55	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
4.55	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
4.55	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
4.55	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.55	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.35	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.35	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
4.35	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
4.17	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.17	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
4.17	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
4.17	Single	8FN0	SBI-553	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
4.17	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
4.17	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.17	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.17	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
4.17	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
4.17	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
4.17	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
4.17	Single	8ZYT	SBI-553	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
4.00	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
4.00	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
4.00	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
3.85	Single	9B5Y	Long-Acting PTH	9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
3.70	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
3.70	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.70	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
3.70	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
3.57	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
3.57	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
3.57	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.45	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.45	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
3.45	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
3.45	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
3.45	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.45	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
3.33	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.33	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
3.33	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
3.33	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
3.33	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.33	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
3.33	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
3.33	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
3.33	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
3.33	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.23	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
3.23	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
3.23	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
3.23	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
3.23	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
3.23	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
3.23	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
3.23	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.23	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
3.23	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.23	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
3.23	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
3.12	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
3.12	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
3.12	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
3.03	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.03	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.03	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
2.94	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
2.94	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
2.94	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.86	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
2.86	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
2.86	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
2.86	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.86	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.78	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.78	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
2.63	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
2.56	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.50	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.50	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp

PDB Summary
PDB	8HNN
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR3
Species	Homo Sapiens
Ligand	SCH546738
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.6
Date	2023-11-29
D.O.I.	doi.org/10.1038/s41594-023-01175-5

Net Summary
I_min	2.52
Number of Linked Nodes	233
Number of Links	256
Number of Hubs	30
Number of Links mediated by Hubs	126
Number of Communities	5
Number of Nodes involved in Communities	39
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	34374
Length Of Smallest Path	3
Average Path Length	11.8799
Length of Longest Path	25
Minimum Path Strength	1.22
Average Path Strength	5.05169
Maximum Path Strength	18.38
Minimum Path Correlation	0.7
Average Path Correlation	0.912002
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	46.8754
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.035
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • dynorphin receptor activity • protein binding • receptor serine/threonine kinase binding • signaling receptor binding • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • cytokine receptor activity • immune receptor activity • chemokine binding • cytokine binding • C-X-C chemokine receptor activity • C-C chemokine binding • C-X-C chemokine binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • multicellular organismal process • system process • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • defense response to virus • defense response • response to other organism • response to stress • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • response to acrylamide • response to chemical • response to oxygen-containing compound • response to nitrogen compound • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to hormone • response to endogenous stimulus • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • response to lipid • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • regulation of potassium ion transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • positive regulation of cytosolic calcium ion concentration • cell adhesion • regulation of cell adhesion • developmental process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to external stimulus • taxis • regulation of locomotion • locomotion • apoptotic process • cell death • programmed cell death • calcium-mediated signaling • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • negative regulation of programmed cell death • negative regulation of execution phase of apoptosis • negative regulation of apoptotic process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • cell chemotaxis • cell migration • cell motility • cell surface receptor signaling pathway • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • regulation of calcium ion transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • maintenance of location • release of sequestered calcium ion into cytosol • cellular localization • inorganic ion homeostasis • calcium ion homeostasis • negative regulation of sequestering of calcium ion • maintenance of location in cell • regulation of calcium ion transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • calcium ion transmembrane transport • inflammatory response • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • regulation of cell migration • regulation of immune system process • lymphocyte chemotaxis • lymphocyte migration • mononuclear cell migration • T cell chemotaxis • T cell migration • leukocyte chemotaxis • negative regulation of cell population proliferation • endothelial cell proliferation • negative regulation of endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • negative regulation of epithelial cell proliferation • cellular anatomical structure • periplasmic space • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • intracellular anatomical structure • cytoplasm • cytosol • presynapse • presynaptic membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • intracellular organelle • organelle • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • vesicle • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • organelle membrane • exocytic vesicle • mitochondrion • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • axon • axon terminus • distal axon • neuron projection terminus • cell surface • external side of plasma membrane • side of membrane
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	43I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	43I
Name	3-azanyl-6-chloranyl-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide
Synonyms
Identifier
Formula	C23 H31 Cl2 N7 O
Molecular Weight	492.445
SMILES
PubChem	11995774
Formal Charge	0
Total Atoms	64
Total Chiral Atoms	1
Total Bonds	67
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8HNN_Chain_R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V Q W V F G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R R G P P A R V T L T C L A V W G L C L L F A L P D F I F L S A H H D E R L N A T H C Q Y N F P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/β1/γ2	3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-		3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/β1/γ2	2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-		2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/β1/γ2	2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-		2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	SCH546738	-	-	3.6	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/β1/γ2	3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-		3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8XXY	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	-	3.68	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	Go/β1/γ2	3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-		3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYI	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	-	3.16	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	Go/β1/γ2	3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-		3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0H	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	-	3.53	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	Go/β1/γ2	3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-		3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w

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