Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F13 5.5725424
2R:R:N15 11.5075427
3R:R:V20 8.07333626
4R:R:P23 9.0875425
5R:R:F24 7.05429725
6R:R:Q28 7.1725425
7R:R:Y29 8.6125494
8R:R:Y30 7.73624
9R:R:L31 6.06524
10R:R:M44 6.42167617
11R:R:H65 8.99735
12R:R:L68 6.782537
13R:R:Y74 8.19754125
14R:R:N78 6.7569
15R:R:F91 6.225417
16R:R:F103 7.91528
17R:R:V104 8.41474
18R:R:E113 5.69405
19R:R:F115 7.7075406
20R:R:F116 6.495404
21R:R:E122 5.82516
22R:R:I123 5.8475467
23R:R:W126 9.90833615
24R:R:S127 5.39468
25R:R:E134 8.1875448
26R:R:R135 8.575649
27R:R:Y136 6.168507
28R:R:F148 8.992547
29R:R:H152 9.79445
30R:R:W161 6.0425469
31R:R:P170 5.595417
32R:R:W175 10.834515
33R:R:Y178 7.722503
34R:R:P180 5.734523
35R:R:E181 7.768514
36R:R:M183 5.415402
37R:R:Q184 6.8075423
38R:R:I189 6.44414
39R:R:D190 9.9775404
40R:R:Y191 7.02516
41R:R:Y192 7.542515
42R:R:H195 14.1625414
43R:R:N200 7.205414
44R:R:F203 10.8883616
45R:R:Y206 10.205414
46R:R:H211 9.70833616
47R:R:F212 4.8225408
48R:R:V230 6.6275458
49R:R:E239 13.075452
50R:R:Q244 7.725454
51R:R:K248 8.482554
52R:R:F261 7.4425409
53R:R:W265 9.11714718
54R:R:Y268 9.846516
55R:R:F287 7.37414
56R:R:M288 7.1325414
57R:R:F293 8.052515
58R:R:K296 6.916517
59R:R:Y306 15.11409
60R:R:Q312 3.7725436
61R:R:F313 9.136508
62R:R:T319 4.9575434
63R:R:P327 7.895435
64R:R:V337 6.83535
65R:R:E341 10.8125435
66L:L:?9 8.575810
67H:H:?1 16.34520
68H:H:?4 15.57580
69H:H:?11 7.634500
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F208 R:R:F212 18.60434.29NoYes058
2L:L:?9 R:R:F212 24.72396.47YesYes008
3L:L:?9 R:R:K296 1007.49YesYes107
4R:R:E113 R:R:K296 83.73015.4YesYes057
5R:R:E113 R:R:F103 83.20254.66YesYes058
6R:R:F103 R:R:F24 44.36815.36YesYes285
7R:R:F24 R:R:P180 36.94485.78YesYes253
8R:R:P180 R:R:P23 39.09515.84YesYes235
9R:R:P23 R:R:Q28 37.01537.9YesYes255
10R:R:Q28 R:R:Y30 51.6359.02YesYes254
11R:R:V20 R:R:Y30 29.631911.36YesYes264
12R:R:C187 R:R:F103 36.75468.38NoYes298
13R:R:C187 R:R:P180 36.19025.65NoYes293
14R:R:P180 R:R:Q184 40.26696.32YesYes233
15R:R:Q184 R:R:Q28 36.76995.12YesYes235
16H:H:?1 R:R:V20 14.84363.99YesYes206
17R:R:Y191 R:R:Y192 10.15644.96YesYes165
18R:R:I189 R:R:Y191 19.80987.25YesYes146
19R:R:I189 R:R:S176 14.97556.19YesNo145
20R:R:N200 R:R:S176 20.90184.47YesNo145
21R:R:D190 R:R:N200 15.08912.12YesYes044
22R:R:L31 R:R:Q28 18.50926.65YesYes245
23R:R:P291 R:R:V271 39.79453.53NoNo065
24R:R:I290 R:R:P291 30.97855.08NoNo056
25R:R:I286 R:R:I290 29.48772.94NoNo015
26R:R:I286 R:R:M183 27.99082.92NoYes012
27R:R:F37 R:R:M183 15.79454.98NoYes052
28R:R:F37 R:R:Y29 12.659513.41NoYes954
29R:R:K296 R:R:M44 10.8194.32YesYes177
30R:R:F91 R:R:K296 17.69027.44YesYes177
31R:R:L95 R:R:M44 10.0464.24NoYes067
32L:L:?9 R:R:E122 98.53686.16YesYes106
33R:R:E122 R:R:W126 91.1384.36YesYes165
34R:R:V129 R:R:W126 99.52763.68NoYes075
35R:R:V129 R:R:V218 97.97243.21NoNo076
36R:R:I133 R:R:V218 97.46011.54NoNo066
37R:R:I133 R:R:V137 96.97241.54NoNo064
38R:R:F148 R:R:V137 79.00619.18YesNo074
39R:R:F148 R:R:P71 62.46634.33YesNo476
40R:R:P71 R:R:T70 74.17185.25NoNo067
41R:R:N73 R:R:T70 73.279111.7NoNo087
42R:R:N73 R:R:Y306 28.69944.65NoYes089
43R:R:F313 R:R:Y306 25.322128.88YesYes089
44R:R:F313 R:R:I307 17.95093.77YesNo087
45R:R:I307 R:R:M317 16.69945.83NoNo076
46R:R:L321 R:R:M317 14.20254.24NoNo066
47H:H:?11 R:R:L321 12.932514.4YesNo006
48R:R:F91 R:R:M86 11.95094.98YesNo077
49R:R:L68 R:R:N73 46.31910.98YesNo078
50R:R:H65 R:R:L68 28.26695.14YesYes357
51R:R:H65 R:R:T319 20.11354.11YesYes354
52R:R:I189 R:R:Y178 18.79756.04YesYes043
53R:R:F115 R:R:Y178 32.40184.13YesYes063
54R:R:F115 R:R:L119 26.021510.96YesNo065
55R:R:L119 R:R:W161 25.41724.56NoYes059
56R:R:N78 R:R:W161 21.17795.65YesYes699
57R:R:N78 R:R:S127 20.09824.47YesYes698
58R:R:I75 R:R:S127 19.2276.19NoYes078
59R:R:I75 R:R:V130 11.31293.07NoNo077
60L:L:?9 R:R:T118 20.51237.83YesNo004
61R:R:T118 R:R:Y178 18.76998.74NoYes043
62R:R:E134 R:R:F148 13.260710.49YesYes487
63R:R:M288 R:R:V271 41.90187.61YesNo045
64R:R:M288 R:R:Y268 38.83139.58YesYes146
65R:R:C264 R:R:W265 12.84366.53NoYes088
66R:R:C264 R:R:Y301 11.57984.03NoNo085
67L:L:?9 R:R:W265 16.141114.37YesYes108
68R:R:I75 R:R:L131 13.56758.56NoNo079
69R:R:L131 R:R:V254 12.99395.96NoNo098
70R:R:E134 R:R:R135 23.80986.98YesYes489
71R:R:R135 R:R:V254 12.80983.92YesNo098
72R:R:R135 R:R:T251 16.058312.94YesNo096
73R:R:P142 R:R:Y136 20.28224.17NoYes087
74R:R:P142 R:R:V137 22.52157.07NoNo084
75R:R:L226 R:R:Y136 13.25464.69NoYes087
76R:R:L226 R:R:V230 11.62274.47NoYes588
77R:R:H211 R:R:Y206 11.162610.89YesYes164
78R:R:D190 R:R:I179 13.19948.4YesNo041
79R:R:K248 R:R:V230 14.03376.07YesYes548
80R:R:P327 R:R:T319 12.72396.99YesYes354
81R:R:I179 R:R:P180 12.90495.08NoYes013
82L:L:?9 R:R:Y268 43.981617.91YesYes106
83R:R:Y191 R:R:Y268 13.34367.94YesYes166
84R:R:H211 R:R:W126 10.70868.46YesYes165
85R:R:E134 R:R:P71 12.58911YesNo486
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 1 Yes Yes 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 7.44 1 Yes Yes 7 7 2 1
R:R:E113 R:R:K296 5.4 0 Yes Yes 5 7 2 1
L:L:?9 R:R:A117 5.23 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 8.74 0 No Yes 4 3 1 2
L:L:?9 R:R:T118 7.83 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 6.63 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 4.36 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 4.56 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 1 Yes Yes 6 6 1 2
L:L:?9 R:R:E122 6.16 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 7.31 0 Yes No 9 7 2 2
R:R:H211 R:R:W126 8.46 1 Yes Yes 6 5 2 2
R:R:C167 R:R:H211 14.74 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 5.61 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 8.98 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 8.12 1 Yes Yes 4 4 2 2
R:R:Y191 R:R:Y268 7.94 1 Yes Yes 6 6 2 1
R:R:F208 R:R:F212 4.29 0 No Yes 5 8 2 1
R:R:F212 R:R:L216 6.09 0 Yes No 8 7 1 2
L:L:?9 R:R:F212 6.47 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 16.04 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 6.53 0 No Yes 8 8 2 1
R:R:W265 R:R:Y268 4.82 1 Yes Yes 8 6 1 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?9 R:R:W265 14.37 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 9.58 1 Yes Yes 4 6 2 1
L:L:?9 R:R:Y268 17.91 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 9.93 1 Yes Yes 5 7 2 1
L:L:?9 R:R:K296 7.49 1 Yes Yes 0 7 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
L:L:?9 R:R:A269 3.14 1 Yes No 0 7 0 1
R:R:F212 R:R:L266 2.44 0 Yes No 8 6 1 2
R:R:A269 R:R:G270 1.95 0 No No 7 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
100.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
88.89Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
88.89Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
80.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
80.00Consensussensory_offOrthosteric Ligandopsin_off
77.78Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
75.00Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
72.73Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
70.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
70.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
70.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
70.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
70.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
70.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
66.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
66.67Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
63.64Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
63.64Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
60.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
60.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
60.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
60.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
60.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
60.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
60.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
60.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
58.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
58.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
58.33Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
54.55Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
54.55Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
54.55Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
54.55Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
54.55Consensusalpha1_onOrthosteric Ligandalpha1a_on
54.55Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
53.85Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
53.85Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
53.85Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
53.85Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
53.33Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
50.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
50.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
50.00Single3RZECidoxepin3RZE-H1-Cidoxepin
50.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
50.00Single4U15Tiotropium4U15-M3-Tiotropium
50.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
50.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
50.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
50.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
50.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
50.00Single6OL9Tiotropium6OL9-M5-Tiotropium
50.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
50.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
50.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
50.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
50.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
50.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
50.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
50.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
50.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
50.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
50.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
50.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
50.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
50.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
50.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
50.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
50.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
50.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
50.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
50.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
50.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
50.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
50.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
46.67Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
46.67Single5CXVTiotropium5CXV-M1-Tiotropium
46.67Single6CM4Risperidone6CM4-D2-Risperidone
46.67Single7DFPSpiperone7DFP-D2-Spiperone
46.67Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
46.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
46.67Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
46.67Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
46.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
46.15Single3NY8ICI 118-5513NY8-β2-ICI 118-551
46.15Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
46.15Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
46.15Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
46.15Single4MQSIperoxo4MQS-M2-Iperoxo
46.15Single4U14Tiotropium4U14-M3-Tiotropium
46.15Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
46.15Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
46.15Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
46.15Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
46.15Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
46.15Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
46.15Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
46.15Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
46.15Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
46.15Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single8JJOAlprenolol8JJO-β2-Alprenolol
46.15Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
46.15Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
46.15Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8X64Desloratadine8X64-H1-Desloratadine
46.15Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
46.15Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
46.15Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
46.15Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
46.15Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
46.15Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
46.15Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Consensushistamine_onOrthosteric Ligandh1_on h4_on
46.15Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
46.15Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
46.15Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
46.15Consensustar_onOrthosteric Ligandta1_on
45.45Single3PBLEticlopride3PBL-D3-Eticlopride
45.45Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
45.45Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
45.45Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
44.44Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
44.44Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
43.75Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
43.75Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
43.75Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
42.86Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
42.86Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
42.86Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
42.86Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
42.86Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
42.86Single6LUQHaloperidol6LUQ-D2-Haloperidol
42.86Single6PS6Timolol6PS6-β2-Timolol
42.86Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
42.86Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
42.86Single8EA0Iperoxo8EA0-M3-Iperoxo
42.86Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
42.86Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
42.86Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
42.86Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
42.86Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
42.86Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
42.86Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
42.86Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single6KUXRS-799486KUX-α2a-RS-79948
41.67Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
41.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
41.67Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
41.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
41.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
41.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
41.67Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
41.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
41.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
41.67Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
41.67Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
41.67Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8GGVEpinephrine8GGV-β2-Epinephrine
41.67Single8GGXEpinephrine8GGX-β2-Epinephrine
41.67Single8GH0Epinephrine8GH0-β2-Epinephrine
41.67Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
41.67Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
41.67Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
41.67Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
41.67Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.67Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Consensusgt_class-aOrthosteric Ligandgt_opsin
41.67Consensusgt_opsinOrthosteric Ligandgt_sensory
41.67Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
41.67Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.67Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
41.18Single7SK9CCX6627SK9-ACKR3-CCX662
41.18Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single2YDVNECA2YDV-A2A-NECA
40.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
40.00Single4UHRCGS216804UHR-A2A-CGS21680
40.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
40.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
40.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
40.00Single5G53NECA5G53-A2A-NECA-Gs
40.00Single5X93K-87945X93-ETB-K-8794
40.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
40.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.00Single6J21Aprepitant6J21-NK1-Aprepitant
40.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
40.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
40.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
40.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
40.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
40.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
40.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
40.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
40.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
40.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
40.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
40.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
40.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
40.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
40.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
40.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
40.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
40.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
40.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
40.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
40.00Consensushistamine_offOrthosteric Ligandh1_off
40.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
40.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
40.00Consensussensory_onOrthosteric Ligandopsin_on
38.89Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
38.46Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
38.46Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
38.46Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
38.46Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
38.46Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
38.46Single6A94Zotepine6A94-5-HT2A-Zotepine
38.46Single6IQLL7458706IQL-D4-L745870
38.46Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
38.46Single6PS4ICI 118-5516PS4-β2-ICI 118-551
38.46Single6TPNHTL66416TPN-OX2-HTL6641
38.46Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
38.46Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
38.46Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
38.46Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
38.46Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.46Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
38.46Single7VODCariprazine7VOD-5-HT2A-Cariprazine
38.46Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
38.46Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
38.46Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8GGIEpinephrine8GGI-β2-Epinephrine
38.46Single8GGQEpinephrine8GGQ-β2-Epinephrine
38.46Single8GGTEpinephrine8GGT-β2-Epinephrine
38.46Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
38.46Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensus5ht5_onOrthosteric Ligand5ht5a_on
38.46Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
38.46Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
38.46Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
38.46Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
37.50Single4AMIBucindolol4AMI-β1-Bucindolol
37.50Single6A93Risperidone6A93-5-HT2A-Risperidone
37.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
37.50Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
37.50Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
37.50Single6HLPNetupitant6HLP-NK1-Netupitant
37.50Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
37.50Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
37.50Single6ZG4HTL00099366ZG4-M1-HTL0009936
37.50Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
37.50Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
37.50Single7YITNalfurafine7YIT-κ-Nalfurafine
37.50Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
37.50Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
37.50Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
36.84Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
36.36Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
36.36Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
36.36Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
35.71Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
35.71Single2Y01Dobutamine2Y01-β1-Dobutamine
35.71Single2Y04Salbutamol2Y04-β1-Salbutamol
35.71Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
35.71Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
35.71Single4DAJTiotropium4DAJ-M3-Tiotropium
35.71Single4EJ4Naltrindole4EJ4-δ-Naltrindole
35.71Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single5DSGTiotropium5DSG-M4-Tiotropium
35.71Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
35.71Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
35.71Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
35.71Single6DRXLisuride6DRX-5-HT2B-Lisuride
35.71Single6H7MSalbutamol6H7M-β1-Salbutamol
35.71Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
35.71Single6PS1Timolol6PS1-β2-Timolol
35.71Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
35.71Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
35.71Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
35.71Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
35.71Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
35.71Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
35.71Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
35.71Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.71Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
35.71Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
35.71Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
35.71Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.71Single7WC7Lisuride7WC7-5-HT2A-Lisuride
35.71Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
35.71Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
35.71Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
35.71Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
35.71Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
35.71Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
35.71Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GGJEpinephrine8GGJ-β2-Epinephrine
35.71Single8GGNEpinephrine8GGN-β2-Epinephrine
35.71Single8GGOEpinephrine8GGO-β2-Epinephrine
35.71Single8GGUEpinephrine8GGU-β2-Epinephrine
35.71Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
35.71Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
35.71Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
35.71Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
35.71Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
35.71Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
35.71Single8X63Mepyramine8X63-H1-Mepyramine
35.71Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
35.71Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
35.71Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
35.71Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
35.71Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
35.71Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
35.71Consensustachykinin_offOrthosteric Ligandnk1_off
35.29Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
35.29Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
35.29Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
35.29Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
35.29Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
35.29Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
35.29Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
35.29Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
35.29Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
35.29Consensusendothelin_offOrthosteric Ligandetb_off
35.29Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
35.29Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.00Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single2Y00Dobutamine2Y00-β1-Dobutamine
33.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
33.33Single3NY9PubChem 9131033NY9-β2-PubChem 913103
33.33Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single4UG2CGS216804UG2-A2A-CGS21680
33.33Single5C1MBU725C1M-μ-BU72
33.33Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
33.33Single5WIUNemonapride5WIU-D4-Nemonapride
33.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
33.33Single5XPRBosentan5XPR-ETB-Bosentan
33.33Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
33.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
33.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
33.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
33.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
33.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
33.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
33.33Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
33.33Single6PT3DPI-2876PT3-δ-DPI-287
33.33Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
33.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
33.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
33.33Single7SRQLSD7SRQ-5-HT2B-LSD
33.33Single7WC6LSD7WC6-5-HT2A-LSD
33.33Single7XKAEpinephrine7XKA-β2-Epinephrine
33.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
33.33Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
33.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
33.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
33.33Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GGSEpinephrine8GGS-β2-Epinephrine
33.33Single8GGYEpinephrine8GGY-β2-Epinephrine
33.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
33.33Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
33.33Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
33.33Single8X5YAstemizole8X5Y-H1-Astemizole
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
33.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
33.33Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
33.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
33.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
33.33Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
33.33Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
33.33Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
33.33Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
33.33Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.82Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
31.58Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
31.58Single4IARErgotamine4IAR-5-HT1B-Ergotamine
31.58Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
31.58Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
31.25Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
31.25Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
31.25Single4RWADIPP-NH24RWA-δ-DIPP-NH2
31.25Single6E59L-7607356E59-NK1-L-760735
31.25Single6H7JIsoprenaline6H7J-β1-Isoprenaline
31.25Single6J20Aprepitant6J20-NK1-Aprepitant
31.25Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
31.25Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.25Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
31.25Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.25Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
31.25Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
31.25Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
31.25Single8E0GBU728E0G-μ-BU72
31.25Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
31.25Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
31.25Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
31.25Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
31.25Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
31.25Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
31.25Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
31.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.25Consensusa2_onOrthosteric Liganda2a_on a2b_on
31.25Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
31.25Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.25Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
31.25Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
31.25Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
31.25Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
30.77Single5DHHSB-6121115DHH-NOP-SB-612111
30.77Single6B73PubChem 1319551386B73-κ-PubChem 131955138
30.77Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
30.77Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
30.77Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
30.77Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
30.77Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
30.77Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
30.77Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
30.77Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
30.77Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
30.77Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8GGWEpinephrine8GGW-β2-Epinephrine
30.77Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8IWESpermidine8IWE-TAAR9-Spermidine
30.77Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
30.77Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
30.77Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
30.77Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
30.77Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
30.77Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
30.77Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
30.77Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single3QAKUK-4320973QAK-A2A-UK-432097
30.00Single6HLOAprepitant6HLO-NK1-Aprepitant
30.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
30.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
30.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.41Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
29.41Single4LDEBI1671074LDE-β2-BI167107
29.41Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
29.41Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
29.41Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.41Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.41Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
29.41Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
29.41Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.41Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
29.41Single8JJ8Formoterol8JJ8-β2-Formoterol
29.41Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
29.41Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
29.41Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
29.41Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
29.41Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
29.17Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
28.57Single2YDOAdenosine2YDO-A2A-Adenosine
28.57Single6DS0Ly2660976DS0-5-HT2B-Ly266097
28.57Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
28.57Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
28.57Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
28.57Single6PT2KGCHM076PT2-δ-KGCHM07
28.57Single6TPGEMPA6TPG-OX2-EMPA
28.57Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
28.57Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
28.57Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
28.57Single7T32ZM2413857T32-A2A-ZM241385
28.57Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
28.57Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
28.57Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
28.57Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GGKEpinephrine8GGK-β2-Epinephrine
28.57Single8GGLEpinephrine8GGL-β2-Epinephrine
28.57Single8GGMEpinephrine8GGM-β2-Epinephrine
28.57Single8GGPEpinephrine8GGP-β2-Epinephrine
28.57Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
28.57Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
28.57Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
27.78Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
27.78Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.78Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
27.78Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
27.78Single6H7LDobutamine6H7L-β1-Dobutamine
27.78Single6IBLArformoterol6IBL-β1-Arformoterol
27.78Single7EZCUKA7EZC-A2A-UKA
27.78Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
27.78Single7UM4AS26747237UM4-5-HT5A-AS2674723
27.78Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
27.78Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
27.78Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
27.78Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
27.78Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
27.78Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single2Y02Carmoterol2Y02-β1-Carmoterol
26.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
26.67Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
26.67Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
26.67Single5TGZAM65385TGZ-CB1-AM6538
26.67Single7BU7BI1671077BU7-β1-BI167107
26.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
26.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
26.67Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
26.67Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
26.67Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
26.67Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
26.67Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
26.67Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.67Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
26.67Single8CU6LJ-45178CU6-A2A-LJ-4517
26.67Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.67Consensusadenosine_onOrthosteric Liganda1_on a2_on
26.67Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.67Consensusblt_onOrthosteric Ligandblt1_on
26.67Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.67Consensusleuko_onOrthosteric Ligandblt_on
26.67Consensusnucleotide_onOrthosteric Ligandadenosine_on
25.00Single3UZAGTPL92363UZA-A2A-GTPL9236
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single5WQCEMPA5WQC-OX2-EMPA
25.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
25.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
25.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single8GGREpinephrine8GGR-β2-Epinephrine
25.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
25.00Single8QOTNanobody E8QOT-μ-Nanobody E
25.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
25.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
25.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
25.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
23.81Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
23.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.53Single3P0GBI1671073P0G-β2-BI167107
23.53Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
23.53Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
23.53Single4DJHJDTic4DJH-κ-JDTic
23.53Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
23.53Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
23.53Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.53Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
23.53Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
23.53Single6WGTLSD6WGT-5-HT2A-LSD
23.53Single7B6WCyclazosin7B6W-α1b-Cyclazosin
23.53Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
23.53Single7EPENAM5637EPE-mGlu-NAM563
23.53Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
23.53Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
23.53Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.53Single7W41PD1762527W41-BB2-PD176252
23.53Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
23.53Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
23.53Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
23.53Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
23.53Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
23.53Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
23.53Consensus5ht5_offOrthosteric Ligand5ht5a_off
23.53Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusadenosine_offOrthosteric Liganda1_off a2_off
23.53Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
23.53Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.53Consensusbombesin_offOrthosteric Ligandbb2_off
23.53Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
23.53Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.53Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
23.53Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
23.53Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
23.53Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
23.08Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.08Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
23.08Single6HLLCP999946HLL-NK1-CP99994
23.08Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
23.08Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.08Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
23.08Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.08Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
23.08Consensusgo_class-b2Orthosteric Ligandgo_adhesion
23.08Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
22.73Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.22Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.22Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
22.22Single6MXTSalmeterol6MXT-β2-Salmeterol
22.22Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.22Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.22Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
22.22Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
22.22Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
22.22Single7K15MKD0467K15-BLT1-MKD046-Na
22.22Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
22.22Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
22.22Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
22.22Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Single8JJLOlodaterol8JJL-β2-Olodaterol
22.22Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
22.22Single8JWZAB9288JWZ-A2A-AB928-Na
22.22Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
22.22Consensusblt_offOrthosteric Ligandblt1_off
22.22Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
22.22Consensusgi_class-fOther Ligandgi_frizzled
22.22Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.22Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.22Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
22.22Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
22.22Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.74Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.74Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
21.43Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
21.43Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
21.43Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.43Single5WS3EMPA5WS3-OX2-EMPA
21.43Single6AKXA4R6AKX-CCR5-A4R
21.43Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.43Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
21.43Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
21.43Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.43Single6TODEMPA6TOD-OX1-EMPA-Na
21.43Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.43Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.43Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
21.43Single7F8ULintitript7F8U-CCKA-Lintitript
21.43Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.43Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.43Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.43Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
21.43Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.43Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
21.43Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.43Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.43Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
21.43Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
21.43Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.43Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
21.43Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
21.43Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
21.43Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.43Consensusmglu_onOther Ligandmglu2_on mglu4_on
21.05Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.05Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
21.05Single5CGDHTL142425CGD-mGlu5-HTL14242
21.05Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.05Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
21.05Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
21.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.05Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
21.05Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
21.05Consensussteroid_onOrthosteric Ligandbileacid_on
20.83Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
20.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5JTBZM2413855JTB-A2A-ZM241385
20.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
20.00Single5UVIZM2413855UVI-A2A-ZM241385
20.00Single5WF6UK-4320975WF6-A2A-UK-432097
20.00Single5ZTYAM102575ZTY-CB2-AM10257
20.00Single6AQFZM2413856AQF-A2A-ZM241385
20.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
20.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6TPKRetosiban6TPK-OT-Retosiban
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6VI4JDTic6VI4-κ-JDTic
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
20.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
20.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
20.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
20.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
20.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
20.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
20.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
20.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
20.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
19.23Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.23Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.23Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.05Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.05Single7F8XNN90567F8X-CCKA-NN9056
19.05Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
19.05Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
19.05Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
19.05Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
19.05Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
19.05Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
19.05Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
19.05Consensussst_onOrthosteric Ligandsst2_on sst4_on
18.75Single3EMLZM2413853EML-A2A-ZM241385
18.75Single4EIYZM2413854EIY-A2A-ZM241385-Na
18.75Single4YAYZD-71554YAY-AT1-ZD-7155
18.75Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.75Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.75Single5K2AZM2413855K2A-A2A-ZM241385-Na
18.75Single5OLGZM2413855OLG-A2A-ZM241385-Na
18.75Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
18.75Single5VRAZM2413855VRA-A2A-ZM241385-Na
18.75Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.75Single6FFHFenobam6FFH-mGlu5-Fenobam
18.75Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
18.75Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.75Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
18.75Single6GPSMK08126GPS-CCR2-MK0812
18.75Single6IIVDaltroban6IIV-TP-Daltroban
18.75Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
18.75Single6S0LZM2413856S0L-A2A-ZM241385
18.75Single6TOTLemborexant6TOT-OX1-Lemborexant
18.75Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.75Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
18.75Single7F83PF-051904577F83-Ghrelin-PF-05190457
18.75Single7PYRPSB-21157PYR-A2A-PSB-2115
18.75Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
18.75Single7UL4Alvimopan7UL4-μ-Alvimopan
18.75Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.75Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
18.75Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
18.75Consensusa2_offOrthosteric Liganda2a_off
18.75Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
18.75Consensuscck_offOrthosteric Ligandccka_off
18.75Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
18.75Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
18.75Consensusgi_hcarOrthosteric Ligandgi_hca
18.75Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.75Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
18.75Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
18.52Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
18.18Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
18.18Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.18Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
17.86Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.65Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.65Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
17.65Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
17.65Single5IUAQ274563485IUA-A2A-Q27456348-Na
17.65Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
17.65Single5N2SPSB365N2S-A1-PSB36
17.65Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
17.65Single6D26Fevipiprant6D26-DP2-Fevipiprant
17.65Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
17.65Single6GPXMK08126GPX-CCR2-MK0812
17.65Single6LPLZM2413856LPL-A2A-ZM241385-Na
17.65Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.65Single6S0QZM2413856S0Q-A2A-ZM241385
17.65Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
17.65Single6TP6Filorexant6TP6-OX1-Filorexant
17.65Single6WQAZM2413856WQA-A2A-ZM241385-Na
17.65Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
17.65Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
17.65Single7C4SS1P7C4S-S1P3-S1P
17.65Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
17.65Single7RM5ZM2413857RM5-A2A-ZM241385-Na
17.65Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
17.65Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
17.65Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
17.65Single8FYNZM2413858FYN-A2A-ZM241385-Na
17.65Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.65Single8GNEKW-63568GNE-A2A-KW-6356-Na
17.65Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
17.65Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
17.65Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
17.65Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
17.65Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.39Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.39Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
17.39Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
17.39Consensusangiotensin_onOrthosteric Ligandat1_on
17.39Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
17.39Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
17.39Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
17.24Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.24Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Single5TZR-5TZR-FFA1 (GPR40)-MK8666
16.67Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single7TUYGSK682753A7TUY-GPR183-GSK682753A
16.67Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
16.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
16.67Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
16.67Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.67Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
16.67Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusgi_class-dOrthosteric Ligandgi_ste
16.67Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
16.67Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
16.67Consensuslpa_offOrthosteric Ligandlpa1_off
16.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
15.79Single4N4WSANT-14N4W-SMO-SANT-1
15.79Single5X33BIIL2605X33-BLT1-BIIL260
15.79Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.79Single6IIURamatroban6IIU-TP-Ramatroban
15.79Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.79Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.79Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.79Single8WU1KCA8WU1-CB1-KCA-Arrestin1
15.79Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
15.79Consensusclass-b2_onOrthosteric Ligandadgrg_on
15.79Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
15.79Consensusdp_offOrthosteric Liganddp2_off
15.79Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
15.79Consensusgs_steroidOrthosteric Ligandgs_bileacid
15.38Single6ME5Agomelatine6ME5-MT1-Agomelatine
15.38Single6ME9Ramelteon6ME9-MT2-Ramelteon
15.38Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
15.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.38Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
15.38Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.38Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusclass-d_onOrthosteric Ligandste2_on
15.38Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.38Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
15.00Single6K1QIRL25006K1Q-ETB-IRL2500
15.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
15.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
15.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
15.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
15.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
15.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusorexin_onOrthosteric Ligandox2_on
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.81Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.81Consensusgi_class-dOrthosteric Ligandgi_ste
14.81Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Consensusgo_class-b1Orthosteric Ligandgo_crf
14.81Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
14.29Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
14.29Single6IGLIRL16206IGL-ETB-IRL1620
14.29Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
14.29Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
14.29Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
14.29Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.29Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7XN9L-054,5227XN9-SST2-L-054,522
14.29Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
14.29Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
14.29Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
14.29Single8GH1Epinephrine8GH1-β2-Epinephrine
14.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
14.29Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
14.29Single8IY6Endothelin-18IY6-ETB-Endothelin-1
14.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
14.29Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8K5BNiacin8K5B-HCA2-Niacin
14.29Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
14.29Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
14.29Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
14.29Consensuslpl_onOrthosteric Ligands1p_on lpa_on
14.29Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.79Single5GLHEndothelin-15GLH-ETB-Endothelin-1
13.79Single6IGKEndothelin-36IGK-ETB-Endothelin-3
13.79Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.79Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
13.64Single7QA8Peptide7QA8-STE2-Peptide
13.64Single7QA8Peptide7QA8-STE2-Peptide
13.64Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.64Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.64Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
13.64Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
13.64Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
13.64Consensusclass-d_offOrthosteric Ligandste2_off
13.64Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.64Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.64Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
13.33Single5K2DZM2413855K2D-A2A-ZM241385
13.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
13.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
13.33Single6JZHZM2413856JZH-A2A-ZM241385-Na
13.33Single6PS7ZM2413856PS7-A2A-ZM241385-Na
13.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
13.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
13.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
13.33Single7XRRLemborexant7XRR-OX2-Lemborexant
13.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
13.33Single8IHKAcifran8IHK-HCA3-Acifran
13.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
13.33Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
13.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
13.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
13.33Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.04Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
13.04Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
13.04Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.04Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.04Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
12.90Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
12.50Single3REYPubChem 56973REY-A2A-PubChem 5697
12.50Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
12.50Single5IU4ZM2413855IU4-A2A-ZM241385-Na
12.50Single5IUBQ274563445IUB-A2A-Q27456344-Na
12.50Single5K2CZM2413855K2C-A2A-ZM241385-Na
12.50Single5NLXZM2413855NLX-A2A-ZM241385-Na
12.50Single5NM4ZM2413855NM4-A2A-ZM241385-Na
12.50Single6MH8ZM2413856MH8-A2A-ZM241385
12.50Single6W25SHU91196W25-MC4-SHU9119-Ca
12.50Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
12.50Single7AROLUF58337ARO-A2A-LUF5833-Na
12.50Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
12.50Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
12.50Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
12.50Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
12.50Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
12.50Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
12.50Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
12.50Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8IYXYL-3658IYX-GPR34-YL-365
12.50Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
12.50Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
12.50Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
12.50Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
12.50Single8K5CAcipimox8K5C-HCA2-Acipimox
12.50Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
12.50Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.50Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.50Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
12.50Consensusgnrh_offOrthosteric Ligandgnrh1_off
12.50Consensushca_onOrthosteric Ligandhca2_on hca3_on
12.50Consensushcar_onOrthosteric Ligandhca_on
12.50Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
12.50Consensuss1p_offOrthosteric Ligands1p1_off
12.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
12.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
12.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
12.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
12.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
12.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single5UENDU1725UEN-A1-DU172
11.76Single6D27CAY104716D27-DP2-CAY10471
11.76Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
11.76Single6LPJZM2413856LPJ-A2A-ZM241385-Na
11.76Single6LPKZM2413856LPK-A2A-ZM241385-Na
11.76Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.76Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.76Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.76Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
11.76Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
11.76Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
11.76Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
11.76Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
11.76Single8K5DGSK2560738K5D-HCA2-GSK256073
11.76Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
11.76Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
11.76Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
11.76Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
11.76Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
11.76Consensushcar_offOrthosteric Ligandsuccinate_off
11.76Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
11.76Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
11.76Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
11.76Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
11.76Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
11.54Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
11.54Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
11.54Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
11.54Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
11.54Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
11.54Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
11.54Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
11.11Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
11.11Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
11.11Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
11.11Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.11Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
11.11Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.11Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
11.11Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
11.11Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7YXAONO-54306087YXA-S1P5-ONO-5430608
11.11Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
11.11Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
11.11Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
11.11Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
11.11Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
11.11Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
11.11Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.11Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
11.11Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
11.11Consensusep_offOrthosteric Ligandep4_off
11.11Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
11.11Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.71Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single5XR8AM8415XR8-CB1-AM841
10.53Single5XRAAM115425XRA-CB1-AM11542
10.53Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.53Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.53Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
10.53Single7P2L4YI7P2L-mGlu5-4YI
10.53Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
10.53Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
10.53Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
10.53Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
10.53Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
10.53Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
10.53Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
10.53Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
10.53Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
10.53Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
10.53Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.53Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Consensuslpa_onOrthosteric Ligandlpa1_on
10.53Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.53Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.53Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
10.34Single6LMLGlucagon6LML-Glucagon-Glucagon
10.34Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
10.34Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
10.34Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
10.34Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
10.34Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
10.34Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
10.34Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
10.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
10.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
10.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
10.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
10.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
10.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
10.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
10.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
10.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
10.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
10.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
10.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
10.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
10.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
10.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
10.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
10.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
10.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
10.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
9.68Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.68Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.68Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
9.68Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
9.52Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.52Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.52Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
9.52Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
9.52Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
9.52Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.52Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
9.52Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
9.52Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
9.52Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
9.52Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
9.52Consensuscyslt_offOrthosteric Ligandcyslt2_off
9.52Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
9.52Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
9.52Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
9.52Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
9.38Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single5EE7MK08935EE7-Glucagon-MK0893
9.09Single5MZPCaffeine5MZP-A2A-Caffeine-Na
9.09Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
9.09Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
9.09Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
9.09Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
9.09Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
9.09Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
9.09Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
9.09Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
9.09Consensusclass-d_offOrthosteric Ligandste2_off
9.09Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
9.09Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
9.09Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
9.09Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
9.09Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusgs_class-b2Orthosteric Ligandgs_adgr
9.09Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
9.09Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
9.09Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
9.09Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
8.82Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.82Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
8.82Consensuspth_onOrthosteric Ligandpth1_on pth2_on
8.70Single4XT1Fractalkine4XT1-US28-Fractalkine
8.70Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
8.70Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.70Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
8.70Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.70Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
8.70Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
8.70Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
8.70Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
8.70Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
8.70Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
8.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
8.33Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
8.33Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
8.33Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
8.33Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
8.33Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single7SHEPI; PE7SHE-GPR158-PI; PE
8.33Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
8.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
8.33Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
8.33Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8PWNTheophylline8PWN-A2A-Theophylline
8.33Consensusclass-c_onOther Ligandgabab_on mglu_on
8.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
8.33Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.33Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
8.00Single3OE0CVX153OE0-CXCR4-CVX15
8.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
8.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
8.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
8.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
8.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.69Single3RFMCaffeine3RFM-A2A-Caffeine
7.69Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.69Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.69Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.69Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
7.69Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
7.69Single8A2OTheophylline8A2O-A2A-Theophylline-Na
7.69Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
7.69Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
7.69Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.69Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
7.69Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
7.69Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.41Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
7.41Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
7.41Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
7.41Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.41Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
7.41Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
7.41Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
7.41Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
7.41Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
7.41Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
7.41Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.41Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
7.14Single3OE6IT1t3OE6-CXCR4-IT1t
7.14Single3OE8IT1t3OE8-CXCR4-IT1t
7.14Single4XT3Fractalkine4XT3-US28-Fractalkine
7.14Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
7.14Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
7.14Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
7.14Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
7.14Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.14Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
7.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
7.14Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
6.90Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
6.90Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
6.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
6.90Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.90Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
6.90Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.90Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
6.90Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.90Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.90Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
6.67Single3OE9IT1t3OE9-CXCR4-IT1t
6.67Single5L7IVismodegib5L7I-SMO-Vismodegib
6.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.67Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
6.67Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
6.67Consensusclass-t_onOrthosteric Ligandtaste2_on
6.67Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.67Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.67Consensusgs_class-tOrthosteric Ligandgs_taste
6.67Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.67Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.45Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
6.25Single3ODUIT1t3ODU-CXCR4-IT1t
6.25Single3PWHZM2413853PWH-A2A-ZM241385
6.25Single4K5YCP-3763954K5Y-CRF1-CP-376395
6.25Single5U09Taranabant5U09-CB1-Taranabant
6.25Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.25Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
6.25Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
6.25Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.25Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
6.25Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
6.25Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
6.25Single8HNNSCH5467388HNN-CXCR3-SCH546738
6.25Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
6.25Consensusglp_onOrthosteric Ligandglp1_on glp2_on
6.25Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
6.06Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
6.06Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.06Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
6.06Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
5.88Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
5.88Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.88Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
5.88Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.88Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
5.88Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
5.88Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88Single8K2WAMG4878K2W-CXCR3-AMG487
5.88Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.88Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.88Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
5.88Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
5.88Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
5.88Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
5.56Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.56Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
5.56Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
5.56Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
5.56Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.56Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.56Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.26Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
5.26Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.26Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.26Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.26Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.26Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.26Single8GTGBMK-I1528GTG-CRF1-BMK-I152
5.26Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.26Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
5.26Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.26Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.00Single6OS1TRV0266OS1-AT1-TRV026
5.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
5.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
5.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
5.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
5.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
5.00Consensuschemerin_onOrthosteric Ligandcml1_on
5.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
5.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
4.76Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.76Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.76Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
4.76Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
4.76Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.76Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.76Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.76Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.76Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.76Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.55Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.55Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.55Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
4.55Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.55Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
4.55Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
4.55Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
4.55Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.35Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
4.35Single6KNMJN241-96KNM-Apelin-JN241-9
4.35Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
4.35Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
4.35Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.35Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
4.35Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
4.17Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
4.17Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
4.17Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
4.17Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
4.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Single7SK5CXCL127SK5-ACKR3-CXCL12
4.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
4.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
4.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Consensussst_offOrthosteric Ligandsst2_off
3.85Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.85Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
3.85Single7XNACYN1548067XNA-SST2-CYN154806
3.85Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
3.85Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
3.85Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
3.70Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
3.70Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
3.70Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
3.70Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
3.57Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.57Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
3.57Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.57Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
3.45Single6FJ3PTH6FJ3-PTH1-PTH
3.45Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.45Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
3.45Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.45Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Single7SK3CXCL127SK3-ACKR3-CXCL12
3.45Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
3.45Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.45Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
3.45Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.45Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.33Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.33Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.33Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
3.23Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.23Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.23Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
3.12Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.12Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.12Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.03Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.03Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
2.94Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
2.94Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
2.86Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
2.86Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.86Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.86Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.78Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.63Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
2.56Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.50Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
2.50Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

PDB Summary
PDB 1U19
Class A
SubFamily Sensory
Type Opsins
SubType Rhodopsin
Species Bos taurus
Ligand 11-cis-Retinal
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.2
Date 2004-10-12
D.O.I. 10.1016/j.jmb.2004.07.044
Net Summary
Imin 3.92
Number of Linked Nodes 345
Number of Links 414
Number of Hubs 69
Number of Links mediated by Hubs 251
Number of Communities 12
Number of Nodes involved in Communities 102
Number of Links involved in Communities 146
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 88124
Length Of Smallest Path 3
Average Path Length 14.667
Length of Longest Path 34
Minimum Path Strength 1.51
Average Path Strength 6.74798
Maximum Path Strength 36.795
Minimum Path Correlation 0.7
Average Path Correlation 0.941566
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 52.9973
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.9961
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeRET
PDB ResiduesL:L:?9
Environment DetailsOpen EMBL-EBI Page
CodeRET
NameRETINAL
Synonyms
Identifier(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal
FormulaC20 H28 O
Molecular Weight284.436
SMILESCC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=O)/C)/C
PubChem638015
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?4 H:H:?5
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeMAN
PDB ResiduesH:H:?3
Environment DetailsOpen EMBL-EBI Page
CodeMAN
Namealpha-D-mannopyranose
Synonymsalpha-D-mannose; D-mannose; mannose
Identifier(2S,3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
FormulaC6 H12 O6
Molecular Weight180.156
SMILESC([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
PubChem185698
Formal Charge0
Total Atoms24
Total Chiral Atoms5
Total Bonds24
Total Aromatic Bonds0

CodePLM
PDB ResiduesH:H:?11 H:H:?12
Environment DetailsOpen EMBL-EBI Page
CodePLM
NamePalmitic Acid
SynonymsHexadecylic acid
Identifierhexadecanoic acid
FormulaC16 H32 O2
Molecular Weight256.424
SMILESCCCCCCCCCCCCCCCC(=O)O
PubChem135369651
Formal Charge0
Total Atoms50
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP02699
Sequence
>1U19_Chain_R
MNGTEGPNF YVPFSNKTG VVRSPFEAP QYYLAEPWQ FSMLAAYMF 
LLIMLGFPI NFLTLYVTV QHKKLRTPL NYILLNLAV ADLFMVFGG 
FTTTLYTSL HGYFVFGPT GCNLEGFFA TLGGEIALW SLVVLAIER 
YVVVCKPMS NFRFGENHA IMGVAFTWV MALACAAPP LVGWSRYIP 
EGMQCSCGI DYYTPHEET NNESFVIYM FVVHFIIPL IVIFFCYGQ 
LVFTVKEAA AQQQESATT QKAEKEVTR MVIIMVIAF LICWLPYAG 
VAFYIFTHQ GSDFGPIFM TIPAFFAKT SAVYNPVIY IMMNKQFRN 
CMVTTLCCG KNPLGDDEA STTVSKTET SQVAPA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
opsin_off1U19-Rhodopsin-11-cis-Retinal
2PED-Rhodopsin-9-cis-Retinal
5TE5-Rhodopsin-20-Methanoretinal

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
1F88ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82000-08-0410.1126/science.289.5480.739
1GZMASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652003-11-2010.1016/j.jmb.2004.08.090
1HZXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82001-07-0410.1021/bi0155091
1L9HASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62002-05-1510.1073/pnas.082666399
1U19ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.22004-10-1210.1016/j.jmb.2004.07.044
2G87ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--2.62006-09-0210.1002/anie.200600595
2HPYASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--2.82006-08-2210.1073/pnas.0601765103
2I35ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.82006-10-1710.1073/pnas.0608022103
2I36ASensoryOpsinsRhodopsinBos taurus---4.12006-10-1710.1073/pnas.0608022103
2I37ASensoryOpsinsRhodopsinBos taurus---4.152006-10-1710.1073/pnas.0608022103
2J4YASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42007-09-2510.1016/j.jmb.2007.03.007
2PEDASensoryOpsinsRhodopsinBos taurus9-cis-Retinal--2.952007-10-3010.1529/biophysj.107.108225
2X72ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)32011-03-1610.1038/nature09795
2Z73ASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--2.52008-05-1310.1038/nature06925
2ZIYASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--3.72008-05-0610.1074/jbc.C800040200
3AYMASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-retinal--2.82011-08-1710.1016/j.jmb.2011.08.044
3AYNASensoryOpsinsRhodopsinTodarodes pacificus9-cis-Retinal--2.72011-08-1710.1016/j.jmb.2011.08.044
3C9LASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652008-08-0510.1107/S0907444908017162
3C9MASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42008-08-0510.1107/S0907444908017162
3CAPASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
3DQBASensoryOpsinsRhodopsinBos taurus--Gt(CT)3.22008-09-2310.1038/nature07330
3OAXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62011-01-1910.1016/j.bpj.2010.08.003
3PQRASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)2.852011-03-0910.1038/nature09789
3PXOASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--32011-03-0910.1038/nature09789
4A4MASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)3.32012-01-2510.1073/pnas.1114089108
4BEYASensoryOpsinsRhodopsinBos taurus--Gt(CT)2.92013-05-0810.1038/embor.2013.44
4BEZASensoryOpsinsRhodopsinBos taurus---3.32013-04-2410.1038/embor.2013.44
4J4QASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Gt(CT)2.652013-10-3010.1002/anie.201302374
4PXFASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop2.752014-09-1710.1038/ncomms5801
4WW3ASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-retinal--2.82015-06-1710.1371/journal.pone.0126970
4X1HASensoryOpsinsRhodopsinBos taurusNonyl Beta-D-Glucopyranoside-Gt(CT)2.292015-11-0410.1016/j.str.2015.09.015
4ZWJASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.32015-07-2910.1038/nature14656
5DGYASensoryOpsinsRhodopsinHomo sapiens--Arrestin17.72016-03-2310.1038/sdata.2016.21
5DYSASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--2.32016-08-1010.15252/embr.201642671
5EN0ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)2.812016-08-1010.15252/embr.201642671
5TE3ASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside--2.72017-03-1510.1073/pnas.1617446114
5TE5ASensoryOpsinsRhodopsinBos taurus20-Methanoretinal--4.012017-03-1510.1073/pnas.1617446114
5W0PASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.012017-08-0910.1016/j.cell.2017.07.002
5WKTASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Gt(CT)3.22017-12-1310.1038/nprot.2017.135
6CMOASensoryOpsinsRhodopsinHomo sapiens--Gi1/&β;1/&γ;24.52018-06-2010.1038/s41586-018-0215-y
6FK6ASensoryOpsinsRhodopsinBos taurus-PubChem 132473033-2.362018-04-0410.1073/pnas.1718084115
6FK7ASensoryOpsinsRhodopsinBos taurus-PubChem 132473034-2.622018-04-0410.1073/pnas.1718084115
6FK8ASensoryOpsinsRhodopsinBos taurus-PubChem 132473035-2.872018-04-0410.1073/pnas.1718084115
6FK9ASensoryOpsinsRhodopsinBos taurus-PubChem 132473036-2.632018-04-0410.1073/pnas.1718084115
6FKAASensoryOpsinsRhodopsinBos taurus-PubChem 132473037-2.72018-04-0410.1073/pnas.1718084115
6FKBASensoryOpsinsRhodopsinBos taurus-PubChem 132473038-3.032018-04-0410.1073/pnas.1718084115
6FKCASensoryOpsinsRhodopsinBos taurus-PubChem 132473039-2.462018-04-0410.1073/pnas.1718084115
6FKDASensoryOpsinsRhodopsinBos taurus-PubChem 137349183-2.492018-04-0410.1073/pnas.1718084115
6FUFASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Go/&β;1/&γ;23.122018-10-0310.1126/sciadv.aat7052
6I9KASensoryOpsinsRhodopsinHasarius adansoni9-cis-Retinal--2.152019-07-0310.1073/pnas.1902192116
6NWEASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Gt(CT)2.712020-02-12To be published
6OFJASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
6OY9ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt/&β;1/&γ;13.92019-07-2410.1016/j.molcel.2019.06.007
6OYAASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt/&β;1/&γ;13.32019-07-2410.1016/j.molcel.2019.06.007
6PELASensoryOpsinsRhodopsinBos taurus-CitronellolGt(CT)3.192020-06-24To be published
6PGSASensoryOpsinsRhodopsinBos taurus-GeraniolGt(CT)2.92020-07-01To be published
6PH7ASensoryOpsinsRhodopsinBos taurus-NerolGt(CT)2.92020-07-01To be published
6QNOASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gi1/&β;1/&γ;14.382019-07-1010.7554/eLife.46041
7MT8ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK15.82021-07-0710.1038/s41586-021-03721-x
7MT9ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK172021-07-0710.1038/s41586-021-03721-x
7MTAASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK14.12021-07-0710.1038/s41586-021-03721-x
7MTBASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK142021-07-0710.1038/s41586-021-03721-x
7ZBCASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7ZBEASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6CASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6DASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6EASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--1.82023-03-2910.1038/s41586-023-05863-6
8FCZASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-3010.1038/s41467-023-40911-9
8FD0ASensoryOpsinsRhodopsinBos taurus---3.712023-08-3010.1038/s41467-023-40911-9
8FD1ASensoryOpsinsRhodopsinBos taurus---4.252023-08-3010.1038/s41467-023-40911-9
3CAP (Dimer)ASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
6OFJ (Dimer)ASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
8FCZ (Dimer)ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-3010.1038/s41467-023-40911-9
8FD0 (Dimer)ASensoryOpsinsRhodopsinBos taurus---3.712023-08-3010.1038/s41467-023-40911-9
8FD1 (Dimer)ASensoryOpsinsRhodopsinBos taurus---4.252023-08-3010.1038/s41467-023-40911-9




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