psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N2	R:R:Y10	4.65	No	Yes	0	6	7
2	R:R:G3	R:R:Y10	4.35	No	Yes	0	6	7
3	R:R:E5	R:R:Y10	6.73	No	Yes	0	6	7
4	R:R:G6	R:R:P7	4.06	No	No	2	6	6
5	R:R:F9	R:R:G6	9.03	Yes	No	2	7	6
6	R:R:N8	R:R:P7	8.15	No	No	0	4	6
7	R:R:F9	R:R:P7	5.78	Yes	No	2	7	6
8	R:R:F24	R:R:N8	4.83	No	No	0	5	4
9	R:R:N8	R:R:P107	3.26	No	No	0	4	3
10	R:R:F9	R:R:S22	9.25	Yes	No	0	7	5
11	R:R:F9	R:R:P23	14.45	Yes	Yes	2	7	5
12	R:R:T193	R:R:Y10	7.49	Yes	Yes	0	5	7
13	R:R:P194	R:R:Y10	9.74	No	Yes	0	1	7
14	R:R:V11	R:R:V20	3.21	Yes	Yes	2	8	6
15	R:R:P23	R:R:V11	3.53	Yes	Yes	2	5	8
16	R:R:Q184	R:R:V11	5.73	Yes	Yes	2	3	8
17	R:R:F13	R:R:L31	3.65	No	No	0	4	4
18	R:R:K16	R:R:S14	9.18	No	No	0	7	4
19	R:R:G18	R:R:N15	3.39	No	No	0	3	7
20	R:R:N15	R:R:V20	7.39	No	Yes	0	7	6
21	R:R:T17	R:R:V19	4.76	No	No	0	6	3
22	R:R:V19	R:R:Y30	3.79	No	Yes	0	3	4
23	R:R:V20	R:R:Y30	6.31	Yes	Yes	0	6	4
24	R:R:R21	R:R:Y30	5.14	No	Yes	0	4	4
25	R:R:E25	R:R:S22	4.31	No	No	0	7	5
26	R:R:P180	R:R:P23	3.9	No	Yes	2	3	5
27	R:R:P23	R:R:Q184	7.9	Yes	Yes	2	5	3
28	R:R:F103	R:R:F24	3.22	Yes	No	0	8	5
29	R:R:F24	R:R:P180	5.78	No	No	0	5	3
30	R:R:P27	R:R:Y29	4.17	No	No	0	8	4
31	R:R:P27	R:R:Y102	8.34	No	No	0	8	4
32	R:R:Q28	R:R:Y30	10.15	No	Yes	0	5	4
33	R:R:L31	R:R:Q28	5.32	No	No	0	4	5
34	R:R:Q184	R:R:Q28	6.4	Yes	No	0	3	5
35	R:R:P34	R:R:Y29	5.56	No	No	0	3	4
36	R:R:F37	R:R:Y29	4.13	No	No	0	5	4
37	R:R:L31	R:R:P285	11.49	No	No	0	4	3
38	R:R:A32	R:R:Q36	3.03	No	No	0	3	2
39	R:R:A32	R:R:M183	3.22	No	Yes	0	3	2
40	R:R:E33	R:R:P34	4.72	No	No	0	3	3
41	R:R:E33	R:R:W35	8.72	No	No	5	3	3
42	R:R:E33	R:R:Q36	6.37	No	No	5	3	2
43	R:R:Q36	R:R:W35	13.14	No	No	5	2	3
44	R:R:F37	R:R:M183	6.22	No	Yes	0	5	2
45	R:R:A41	R:R:S98	3.42	No	No	0	5	5
46	R:R:A41	R:R:L99	3.15	No	No	0	5	4
47	R:R:L47	R:R:Y43	14.07	No	No	0	7	4
48	R:R:F293	R:R:Y43	21.66	No	No	0	5	4
49	R:R:T297	R:R:Y43	6.24	No	No	0	6	4
50	R:R:F91	R:R:M44	4.98	Yes	No	1	7	7
51	R:R:M44	R:R:T94	3.01	No	No	0	7	7
52	R:R:K296	R:R:M44	4.32	No	No	1	7	7
53	R:R:F45	R:R:M49	6.22	No	No	0	3	5
54	R:R:F91	R:R:L47	10.96	Yes	No	0	7	7
55	R:R:L47	R:R:V300	2.98	No	No	0	7	7
56	R:R:I48	R:R:V87	4.61	No	No	0	6	6
57	R:R:L50	R:R:V300	4.47	No	No	0	5	7
58	R:R:G51	R:R:V300	3.68	No	No	0	8	7
59	R:R:F52	R:R:P53	5.78	No	No	0	6	4
60	R:R:F52	R:R:F88	5.36	No	No	0	6	4
61	R:R:I54	R:R:P303	5.08	No	No	0	8	9
62	R:R:I54	R:R:M308	2.92	No	No	0	8	6
63	R:R:D83	R:R:N55	6.73	No	No	0	9	9
64	R:R:L84	R:R:N55	4.12	No	No	0	7	9
65	R:R:N55	R:R:P303	6.52	No	No	0	9	9
66	R:R:L57	R:R:Y60	3.52	No	Yes	0	6	3
67	R:R:I307	R:R:T58	4.56	Yes	No	6	7	9
68	R:R:F313	R:R:T58	5.19	Yes	No	6	8	9
69	R:R:Q64	R:R:Y60	21.42	No	Yes	0	5	3
70	R:R:L68	R:R:V61	2.98	Yes	No	0	7	7
71	R:R:M317	R:R:V61	3.04	No	No	0	6	7
72	R:R:T320	R:R:V61	4.76	No	No	0	5	7
73	R:R:L68	R:R:T62	7.37	Yes	No	0	7	7
74	R:R:L77	R:R:T62	10.32	No	No	0	5	7
75	R:R:H65	R:R:K67	6.55	No	No	7	5	5
76	R:R:C316	R:R:H65	8.85	No	No	7	5	5
77	R:R:C316	R:R:K67	3.23	No	No	7	5	5
78	R:R:F313	R:R:L68	12.18	Yes	Yes	0	8	7
79	R:R:P71	R:R:T70	5.25	No	No	0	6	7
80	R:R:N73	R:R:T70	8.77	No	No	0	8	7
81	R:R:F313	R:R:N73	9.67	Yes	No	0	8	8
82	R:R:E150	R:R:Y74	13.47	No	No	0	2	5
83	R:R:I75	R:R:V130	3.07	Yes	No	0	7	7
84	R:R:I75	R:R:L131	4.28	Yes	No	0	7	9
85	R:R:E134	R:R:I75	10.93	No	Yes	0	8	7
86	R:R:I123	R:R:N78	4.25	Yes	Yes	3	7	9
87	R:R:N78	R:R:V157	11.82	Yes	No	0	9	7
88	R:R:N78	R:R:T160	7.31	Yes	No	3	9	7
89	R:R:N78	R:R:W161	4.52	Yes	No	3	9	9
90	R:R:D83	R:R:L79	5.43	No	No	0	9	9
91	R:R:L79	R:R:S127	6.01	No	No	0	9	8
92	R:R:L128	R:R:L79	4.15	No	No	0	8	9
93	R:R:A82	R:R:I123	3.25	No	Yes	0	8	7
94	R:R:A299	R:R:D83	4.63	No	No	0	9	9
95	R:R:F85	R:R:W161	4.01	No	No	0	6	9
96	R:R:G121	R:R:M86	3.49	No	No	0	7	7
97	R:R:A299	R:R:M86	4.83	No	No	0	9	7
98	R:R:F91	R:R:V87	6.55	Yes	No	0	7	6
99	R:R:E113	R:R:G90	4.91	No	No	0	5	6
100	R:R:F91	R:R:K296	9.93	Yes	No	1	7	7
101	R:R:T92	R:R:T93	3.14	No	No	0	8	5
102	R:R:E113	R:R:T93	11.29	No	No	0	5	5
103	R:R:S186	R:R:T94	3.2	No	No	0	5	7
104	R:R:H100	R:R:Y96	3.27	No	No	0	4	4
105	R:R:F103	R:R:T97	10.38	Yes	No	0	8	5
106	R:R:C185	R:R:T97	5.07	No	No	0	5	5
107	R:R:C185	R:R:S98	3.44	No	No	0	5	5
108	R:R:V104	R:R:Y102	7.57	No	No	0	4	4
109	R:R:F103	R:R:F105	8.57	Yes	No	0	8	7
110	R:R:C110	R:R:F103	8.38	No	Yes	4	9	8
111	R:R:C187	R:R:F103	4.19	Yes	Yes	4	9	8
112	R:R:F105	R:R:G109	3.01	No	No	0	7	5
113	R:R:G106	R:R:P107	4.06	No	No	0	8	3
114	R:R:C110	R:R:C187	7.28	No	Yes	4	9	9
115	R:R:N111	R:R:Y178	8.14	No	Yes	0	7	3
116	R:R:F116	R:R:L112	4.87	No	No	0	4	4
117	R:R:C187	R:R:E113	6.08	Yes	No	0	9	5
118	R:R:G114	R:R:Y178	8.69	No	Yes	0	5	3
119	R:R:F115	R:R:F116	4.29	Yes	No	0	6	4
120	R:R:F115	R:R:L119	3.65	Yes	No	0	6	5
121	R:R:F115	R:R:L172	6.09	Yes	No	1	6	5
122	R:R:F115	R:R:Y178	4.13	Yes	Yes	1	6	3
123	L:L:?1	R:R:A117	3.14	Yes	No	0	0	5
124	R:R:A168	R:R:T118	3.36	No	No	0	7	4
125	R:R:T118	R:R:Y178	4.99	No	Yes	1	4	3
126	R:R:I189	R:R:T118	4.56	Yes	No	1	4	4
127	R:R:I123	R:R:L119	4.28	Yes	No	0	7	5
128	R:R:E122	R:R:W126	7.63	Yes	Yes	1	6	5
129	R:R:C167	R:R:E122	12.15	No	Yes	1	5	6
130	R:R:E122	R:R:H211	11.08	Yes	Yes	1	6	6
131	L:L:?1	R:R:E122	3.52	Yes	Yes	1	0	6
132	R:R:I123	R:R:T160	3.04	Yes	No	3	7	7
133	R:R:I123	R:R:W161	9.4	Yes	No	3	7	9
134	R:R:L125	R:R:P215	3.28	No	No	0	7	9
135	R:R:F261	R:R:L125	4.87	Yes	No	1	9	7
136	R:R:L125	R:R:W265	20.5	No	Yes	1	7	8
137	R:R:V129	R:R:W126	4.9	No	Yes	0	7	5
138	R:R:F159	R:R:W126	4.01	No	Yes	1	3	5
139	R:R:M163	R:R:W126	19.78	No	Yes	1	4	5
140	R:R:H211	R:R:W126	8.46	Yes	Yes	1	6	5
141	R:R:L128	R:R:N302	4.12	No	No	1	8	9
142	R:R:L128	R:R:Y306	16.41	No	Yes	1	8	9
143	R:R:I219	R:R:V129	3.07	No	No	0	8	7
144	R:R:T160	R:R:V130	3.17	No	No	0	7	7
145	R:R:L131	R:R:R135	6.07	No	No	0	9	9
146	R:R:L131	R:R:Y306	5.86	No	Yes	0	9	9
147	R:R:I133	R:R:V218	3.07	No	No	0	6	6
148	R:R:C222	R:R:I133	3.27	No	No	0	8	6
149	R:R:E134	R:R:F148	11.66	No	No	0	8	7
150	R:R:M257	R:R:R135	3.72	Yes	No	0	8	9
151	R:R:C140	R:R:Y136	6.72	No	Yes	0	7	7
152	R:R:P142	R:R:Y136	9.74	No	Yes	0	8	7
153	R:R:F221	R:R:Y136	4.13	No	Yes	8	4	7
154	R:R:C222	R:R:Y136	6.72	No	Yes	0	8	7
155	R:R:Q225	R:R:Y136	3.38	No	Yes	8	4	7
156	R:R:P142	R:R:V137	7.07	No	No	0	8	4
157	R:R:M143	R:R:V137	4.56	No	No	0	6	4
158	R:R:L226	R:R:V139	4.47	No	No	0	8	8
159	R:R:C140	R:R:L226	3.17	No	No	0	7	8
160	R:R:C140	R:R:T229	3.38	No	No	0	7	6
161	R:R:F146	R:R:M143	13.68	No	No	0	5	6
162	R:R:F146	R:R:H152	6.79	No	No	0	5	5
163	R:R:F148	R:R:H152	5.66	No	No	0	7	5
164	R:R:F159	R:R:M163	7.46	No	No	1	3	4
165	R:R:C167	R:R:M207	3.24	No	Yes	1	5	5
166	R:R:C167	R:R:H211	7.37	No	Yes	1	5	6
167	R:R:P170	R:R:P171	5.84	No	Yes	0	7	5
168	R:R:P170	R:R:W175	5.4	No	Yes	0	7	5
169	R:R:P171	R:R:S176	3.56	Yes	No	0	5	5
170	R:R:P171	R:R:Y178	18.08	Yes	Yes	1	5	3
171	R:R:I189	R:R:P171	5.08	Yes	Yes	1	4	5
172	R:R:L172	R:R:Y178	3.52	No	Yes	1	5	3
173	R:R:F203	R:R:W175	12.03	Yes	Yes	1	6	5
174	R:R:W175	R:R:Y206	8.68	Yes	Yes	1	5	4
175	R:R:N200	R:R:S176	2.98	Yes	No	0	4	5
176	R:R:F203	R:R:S176	13.21	Yes	No	0	6	5
177	R:R:I179	R:R:R177	3.76	No	Yes	1	1	5
178	R:R:D190	R:R:R177	5.96	Yes	Yes	1	4	5
179	R:R:R177	R:R:T193	3.88	Yes	Yes	1	5	5
180	R:R:H195	R:R:R177	22.57	No	Yes	0	4	5
181	R:R:I189	R:R:Y178	4.84	Yes	Yes	1	4	3
182	R:R:D190	R:R:I179	4.2	Yes	No	1	4	1
183	R:R:I179	R:R:Y192	6.04	No	Yes	1	1	5
184	R:R:P180	R:R:Q184	3.16	No	Yes	2	3	3
185	R:R:E181	R:R:G182	3.27	Yes	No	0	4	3
186	R:R:E181	R:R:G188	6.55	Yes	No	0	4	5
187	R:R:E181	R:R:Y191	10.1	Yes	Yes	1	4	6
188	R:R:E181	R:R:Y192	4.49	Yes	Yes	1	4	5
189	R:R:M183	R:R:T289	4.52	Yes	No	0	2	4
190	R:R:F203	R:R:I189	5.02	Yes	Yes	1	6	4
191	R:R:I189	R:R:M207	2.92	Yes	Yes	1	4	5
192	L:L:?1	R:R:I189	3.8	Yes	Yes	1	0	4
193	R:R:D190	R:R:T193	13.01	Yes	Yes	1	4	5
194	R:R:D190	R:R:N200	12.12	Yes	Yes	1	4	4
195	R:R:Y191	R:R:Y192	10.92	Yes	Yes	1	6	5
196	R:R:Y191	R:R:Y268	3.97	Yes	Yes	1	6	6
197	R:R:V271	R:R:Y191	5.05	No	Yes	0	5	6
198	R:R:N200	R:R:T193	4.39	Yes	Yes	1	4	5
199	R:R:E197	R:R:H195	6.15	No	No	0	3	4
200	R:R:H195	R:R:T198	6.85	No	No	0	4	1
201	R:R:E201	R:R:F276	4.66	No	No	0	3	4
202	R:R:F203	R:R:Y206	4.13	Yes	Yes	1	6	4
203	R:R:F203	R:R:M207	12.44	Yes	Yes	1	6	5
204	R:R:F276	R:R:I205	5.02	No	No	0	4	5
205	R:R:M207	R:R:Y206	3.59	Yes	Yes	1	5	4
206	R:R:V210	R:R:Y206	6.31	No	Yes	1	4	4
207	R:R:H211	R:R:Y206	4.36	Yes	Yes	1	6	4
208	R:R:H211	R:R:M207	3.94	Yes	Yes	1	6	5
209	L:L:?1	R:R:M207	8.46	Yes	Yes	1	0	5
210	R:R:F208	R:R:F212	4.29	No	Yes	1	5	8
211	R:R:F208	R:R:I213	3.77	No	No	1	5	4
212	R:R:H211	R:R:V210	4.15	Yes	No	1	6	4
213	R:R:F212	R:R:I213	3.77	Yes	No	1	8	4
214	R:R:A269	R:R:F212	8.32	No	Yes	0	7	8
215	R:R:I214	R:R:P215	3.39	No	No	0	5	9
216	R:R:F220	R:R:L216	10.96	No	Yes	1	5	7
217	R:R:L216	R:R:L262	4.15	Yes	No	1	7	6
218	R:R:F261	R:R:I219	7.54	Yes	No	0	9	8
219	R:R:F220	R:R:L262	3.65	No	No	1	5	6
220	R:R:F221	R:R:Q225	4.68	No	No	8	4	4
221	R:R:V254	R:R:Y223	7.57	No	No	0	8	9
222	R:R:M257	R:R:Y223	10.78	Yes	No	0	8	9
223	R:R:V227	R:R:V254	4.81	No	No	0	5	8
224	R:R:V230	R:R:V250	4.81	No	No	0	8	8
225	R:R:E232	R:R:Q236	3.82	No	No	0	4	2
226	R:R:A234	R:R:E247	3.02	No	No	0	5	7
227	R:R:S240	R:R:T243	7.99	No	No	0	4	5
228	R:R:E247	R:R:K248	10.8	No	No	0	7	4
229	R:R:E249	R:R:R252	8.14	No	No	0	7	7
230	R:R:I256	R:R:R252	5.01	No	No	0	5	7
231	R:R:M253	R:R:M309	7.22	No	No	0	8	7
232	R:R:I256	R:R:I305	4.42	No	No	0	5	8
233	R:R:I305	R:R:M257	2.92	No	Yes	1	8	8
234	R:R:M257	R:R:Y306	15.57	Yes	Yes	1	8	9
235	R:R:A260	R:R:Y301	5.34	No	Yes	0	7	5
236	R:R:F261	R:R:W265	9.02	Yes	Yes	1	9	8
237	R:R:L262	R:R:L266	5.54	No	No	0	6	6
238	R:R:C264	R:R:W265	6.53	No	Yes	1	8	8
239	R:R:C264	R:R:S298	5.16	No	No	1	8	9
240	R:R:C264	R:R:Y301	6.72	No	Yes	1	8	5
241	R:R:W265	R:R:Y268	3.86	Yes	Yes	1	8	6
242	L:L:?1	R:R:W265	3.79	Yes	Yes	1	0	8
243	R:R:F294	R:R:P267	4.33	No	No	0	7	9
244	R:R:P291	R:R:Y268	8.34	No	Yes	0	6	6
245	R:R:A295	R:R:Y268	5.34	No	Yes	0	8	6
246	L:L:?1	R:R:Y268	20.27	Yes	Yes	1	0	6
247	R:R:F273	R:R:T277	6.49	No	No	0	6	5
248	R:R:H278	R:R:Y274	29.4	No	No	0	3	4
249	R:R:F283	R:R:Y274	4.13	Yes	No	0	4	4
250	R:R:F283	R:R:I275	5.02	Yes	No	1	4	4
251	R:R:I275	R:R:M288	2.92	No	No	1	4	4
252	R:R:F283	R:R:S281	7.93	Yes	No	0	4	4
253	R:R:F283	R:R:F287	16.08	Yes	No	0	4	4
254	R:R:F283	R:R:M288	3.73	Yes	No	1	4	4
255	R:R:G284	R:R:P285	4.06	No	No	0	4	3
256	R:R:I290	R:R:P291	3.39	No	No	0	5	6
257	R:R:F293	R:R:F294	4.29	No	No	0	5	7
258	L:L:?1	R:R:K296	10.31	Yes	No	1	0	7
259	R:R:T297	R:R:Y301	4.99	No	Yes	0	6	5
260	R:R:S298	R:R:Y301	3.82	No	Yes	1	9	5
261	R:R:N302	R:R:S298	7.45	No	No	1	9	9
262	R:R:N302	R:R:Y306	5.81	No	Yes	1	9	9
263	R:R:I307	R:R:P303	5.08	Yes	No	0	7	9
264	R:R:I305	R:R:Y306	3.63	No	Yes	1	8	9
265	R:R:F313	R:R:I307	7.54	Yes	Yes	6	8	7
266	R:R:F313	R:R:N310	6.04	Yes	No	0	8	8
267	R:R:N315	R:R:R314	3.62	No	No	0	5	8
268	R:R:N326	R:R:R314	3.62	No	No	0	3	8
269	R:R:I307	R:R:L76	2.85	Yes	No	0	7	8
270	R:R:L40	R:R:M183	2.83	No	Yes	0	5	2
271	R:R:C185	R:R:F37	2.79	No	No	0	5	5
272	R:R:A26	R:R:R21	2.77	No	No	0	2	4
273	R:R:L95	R:R:L99	2.77	No	No	0	6	4
274	R:R:H278	R:R:T277	2.74	No	No	0	3	5
275	R:R:A153	R:R:Y74	2.67	No	No	0	7	5
276	R:R:A132	R:R:Y223	2.67	No	No	0	9	9
277	R:R:E134	R:R:L72	2.65	No	No	0	8	8
278	R:R:F220	R:R:V258	2.62	No	No	0	5	8
279	R:R:H65	R:R:L68	2.57	No	Yes	0	5	7
280	R:R:H152	R:R:N151	2.55	No	No	0	5	4
281	R:R:T320	R:R:Y60	2.5	No	Yes	0	5	3
282	R:R:K66	R:R:R69	2.48	No	No	0	6	6
283	R:R:F88	R:R:L84	2.44	No	No	0	4	7
284	R:R:F115	R:R:L165	2.44	Yes	No	0	6	3
285	R:R:F212	R:R:L216	2.44	Yes	Yes	1	8	7
286	R:R:F261	R:R:L216	2.44	Yes	Yes	1	9	7
287	R:R:I275	R:R:Y192	2.42	No	Yes	1	4	5
288	R:R:I263	R:R:Y301	2.42	No	Yes	0	5	5
289	R:R:F228	R:R:Q225	2.34	No	No	0	3	4
290	R:R:N199	R:R:W175	2.26	No	Yes	0	3	5
291	R:R:G89	R:R:G90	2.11	No	No	0	4	6
292	R:R:G120	R:R:G121	2.11	No	No	0	8	7
293	R:R:F56	R:R:Y60	2.06	No	Yes	0	4	3
294	R:R:G149	R:R:P71	2.03	No	No	0	6	6
295	R:R:C187	R:R:G114	1.96	Yes	No	0	9	5
296	R:R:A124	R:R:G121	1.95	No	No	0	9	7
297	R:R:A169	R:R:P170	1.87	No	No	0	3	7
298	R:R:G109	R:R:T108	1.82	No	No	0	5	1
299	R:R:P12	R:R:V11	1.77	No	Yes	0	8	8
300	R:R:G156	R:R:I75	1.76	No	Yes	0	6	7
301	R:R:A80	R:R:T58	1.68	No	No	0	9	9
302	R:R:A234	R:R:T243	1.68	No	No	0	5	5
303	R:R:A292	R:R:T289	1.68	No	No	0	5	4
304	R:R:K141	R:R:P142	1.67	No	No	0	6	8
305	R:R:A164	R:R:I123	1.62	No	Yes	0	8	7
306	R:R:V138	R:R:V139	1.6	No	No	0	8	8
307	R:R:V209	R:R:V210	1.6	No	No	0	5	4
308	R:R:V250	R:R:V254	1.6	No	No	0	8	8
309	R:R:T4	R:R:V11	1.59	No	Yes	2	6	8
310	R:R:T4	R:R:V20	1.59	No	Yes	2	6	6
311	R:R:T251	R:R:V250	1.59	No	No	0	6	8
312	R:R:A80	R:R:L59	1.58	No	No	0	9	7
313	R:R:E150	R:R:P71	1.57	No	No	0	2	6
314	R:R:T319	R:R:T320	1.57	No	No	0	4	5
315	R:R:A234	R:R:Q244	1.52	No	No	0	5	4
316	R:R:I286	R:R:T289	1.52	No	No	0	1	4
317	R:R:N78	R:R:V81	1.48	Yes	No	0	9	6
318	R:R:N200	R:R:V204	1.48	Yes	No	0	4	4
319	R:R:Q237	R:R:S240	1.44	No	No	0	5	4
320	R:R:M253	R:R:M257	1.44	No	Yes	0	8	8
321	R:R:Q64	R:R:V63	1.43	No	No	0	5	2
322	R:R:E247	R:R:V230	1.43	No	No	0	7	8
323	R:R:L46	R:R:L50	1.38	No	No	0	5	5
324	R:R:E150	R:R:I154	1.37	No	No	0	2	3
325	R:R:A166	R:R:Y206	1.33	No	Yes	0	4	4
326	R:R:A272	R:R:Y191	1.33	No	Yes	0	5	6
327	R:R:N73	R:R:Q312	1.32	No	No	0	8	6
328	R:R:F159	R:R:V162	1.31	No	No	0	3	4
329	R:R:R69	R:R:T62	1.29	No	No	0	6	7
330	R:R:F45	R:R:I48	1.26	No	No	0	3	6
331	R:R:E232	R:R:F228	1.17	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F9	9.6275	4	2	7
2	R:R:Y10	6.592	5	0	7
3	R:R:V11	3.166	5	2	8
4	R:R:V20	4.625	4	2	6
5	R:R:P23	7.445	4	2	5
6	R:R:Y30	6.3475	4	0	4
7	R:R:Y60	7.375	4	0	3
8	R:R:L68	6.275	4	0	7
9	R:R:I75	5.01	4	0	7
10	R:R:N78	5.876	5	3	9
11	R:R:F91	8.105	4	1	7
12	R:R:F103	6.948	5	4	8
13	R:R:F115	4.12	5	1	6
14	R:R:E122	8.595	4	1	6
15	R:R:I123	4.30667	6	3	7
16	R:R:W126	8.956	5	1	5
17	R:R:Y136	6.138	5	8	7
18	R:R:P171	8.14	4	1	5
19	R:R:W175	7.0925	4	1	5
20	R:R:R177	9.0425	4	1	5
21	R:R:Y178	7.48429	7	1	3
22	R:R:E181	6.1025	4	1	4
23	R:R:M183	4.1975	4	0	2
24	R:R:Q184	5.7975	4	2	3
25	R:R:C187	4.8775	4	4	9
26	R:R:I189	4.37	6	1	4
27	R:R:D190	8.8225	4	1	4
28	R:R:Y191	6.274	5	1	6
29	R:R:Y192	5.9675	4	1	5
30	R:R:T193	7.1925	4	1	5
31	R:R:N200	5.2425	4	1	4
32	R:R:F203	9.366	5	1	6
33	R:R:Y206	4.73333	6	1	4
34	R:R:M207	5.765	6	1	5
35	R:R:H211	6.56	6	1	6
36	R:R:F212	4.705	4	1	8
37	R:R:L216	4.9975	4	1	7
38	R:R:M257	6.886	5	1	8
39	R:R:F261	5.9675	4	1	9
40	R:R:W265	8.74	5	1	8
41	R:R:Y268	8.356	5	1	6
42	R:R:F283	7.378	5	1	4
43	R:R:Y301	4.658	5	1	5
44	R:R:Y306	9.456	5	1	9
45	R:R:I307	5.0075	4	6	7
46	R:R:F313	8.124	5	6	8
47	L:L:?1	7.61286	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F24	R:R:N8	11.7458	4.83	No	No	0	5	4
2	R:R:F103	R:R:F24	52.2679	3.22	Yes	No	0	8	5
3	R:R:C187	R:R:F103	80.0475	4.19	Yes	Yes	4	9	8
4	R:R:C187	R:R:G114	86.73	1.96	Yes	No	0	9	5
5	R:R:G114	R:R:Y178	87.5949	8.69	No	Yes	0	5	3
6	R:R:P171	R:R:Y178	14.7574	18.08	Yes	Yes	1	5	3
7	R:R:P171	R:R:S176	18.2384	3.56	Yes	No	0	5	5
8	R:R:N200	R:R:S176	29.9473	2.98	Yes	No	0	4	5
9	R:R:N200	R:R:T193	19.3143	4.39	Yes	Yes	1	4	5
10	R:R:T193	R:R:Y10	19.7838	7.49	Yes	Yes	0	5	7
11	R:R:P180	R:R:P23	14.3407	3.9	No	Yes	2	3	5
12	R:R:F24	R:R:P180	40.0949	5.78	No	No	0	5	3
13	R:R:P180	R:R:Q184	24.462	3.16	No	Yes	2	3	3
14	R:R:Q184	R:R:Q28	14.8418	6.4	Yes	No	0	3	5
15	R:R:F103	R:R:T97	32.8323	10.38	Yes	No	0	8	5
16	R:R:C185	R:R:T97	31.4504	5.07	No	No	0	5	5
17	R:R:C185	R:R:F37	24.3829	2.79	No	No	0	5	5
18	R:R:F37	R:R:Y29	10.8544	4.13	No	No	0	5	4
19	R:R:F37	R:R:M183	12.384	6.22	No	Yes	0	5	2
20	R:R:F91	R:R:L47	12.1835	10.96	Yes	No	0	7	7
21	R:R:F91	R:R:K296	16.8302	9.93	Yes	No	1	7	7
22	L:L:?1	R:R:K296	23.1224	10.31	Yes	No	1	0	7
23	L:L:?1	R:R:I189	78.9135	3.8	Yes	Yes	1	0	4
24	R:R:F203	R:R:I189	12.6319	5.02	Yes	Yes	1	6	4
25	R:R:F203	R:R:S176	14.3671	13.21	Yes	No	0	6	5
26	L:L:?1	R:R:M207	17.0992	8.46	Yes	Yes	1	0	5
27	R:R:I179	R:R:Y192	13.2648	6.04	No	Yes	1	1	5
28	R:R:Y191	R:R:Y192	26.1498	10.92	Yes	Yes	1	6	5
29	R:R:Y191	R:R:Y268	34.2194	3.97	Yes	Yes	1	6	6
30	R:R:W265	R:R:Y268	23.3597	3.86	Yes	Yes	1	8	6
31	R:R:C264	R:R:W265	96.097	6.53	No	Yes	1	8	8
32	R:R:T297	R:R:Y301	10.6118	4.99	No	Yes	0	6	5
33	L:L:?1	R:R:W265	78.8977	3.79	Yes	Yes	1	0	8
34	R:R:D83	R:R:N55	64.7521	6.73	No	No	0	9	9
35	R:R:D83	R:R:L79	72.7584	5.43	No	No	0	9	9
36	R:R:L128	R:R:L79	75.3428	4.15	No	No	0	8	9
37	R:R:L128	R:R:N302	58.75	4.12	No	No	1	8	9
38	R:R:N302	R:R:S298	100	7.45	No	No	1	9	9
39	R:R:C264	R:R:S298	90.4061	5.16	No	No	1	8	9
40	R:R:N55	R:R:P303	57.7901	6.52	No	No	0	9	9
41	R:R:T320	R:R:V61	12.2468	4.76	No	No	0	5	7
42	R:R:L68	R:R:V61	15.6804	2.98	Yes	No	0	7	7
43	R:R:F313	R:R:L68	28.9768	12.18	Yes	Yes	0	8	7
44	R:R:F313	R:R:I307	45.6593	7.54	Yes	Yes	6	8	7
45	R:R:I307	R:R:P303	53.4863	5.08	Yes	No	0	7	9
46	R:R:F313	R:R:N73	15.6857	9.67	Yes	No	0	8	8
47	R:R:N73	R:R:T70	12.3259	8.77	No	No	0	8	7
48	R:R:P71	R:R:T70	10.596	5.25	No	No	0	6	7
49	R:R:I75	R:R:V130	28.2595	3.07	Yes	No	0	7	7
50	R:R:T160	R:R:V130	28.2911	3.17	No	No	0	7	7
51	R:R:I123	R:R:T160	25.2584	3.04	Yes	No	3	7	7
52	R:R:I123	R:R:L119	30.0422	4.28	Yes	No	0	7	5
53	R:R:F115	R:R:L119	30.385	3.65	Yes	No	0	6	5
54	R:R:F115	R:R:Y178	32.3154	4.13	Yes	Yes	1	6	3
55	R:R:I75	R:R:L131	34.8523	4.28	Yes	No	0	7	9
56	R:R:L131	R:R:Y306	31.693	5.86	No	Yes	0	9	9
57	R:R:N302	R:R:Y306	40.6751	5.81	No	Yes	1	9	9
58	R:R:E134	R:R:I75	39.9789	10.93	No	Yes	0	8	7
59	L:L:?1	R:R:E122	10.9863	3.52	Yes	Yes	1	0	6
60	R:R:F261	R:R:W265	18.6709	9.02	Yes	Yes	1	9	8
61	R:R:M257	R:R:Y306	29.0401	15.57	Yes	Yes	1	8	9
62	R:R:P142	R:R:Y136	24.0665	9.74	No	Yes	0	8	7
63	R:R:P142	R:R:V137	27.347	7.07	No	No	0	8	4
64	R:R:M143	R:R:V137	28.9715	4.56	No	No	0	6	4
65	R:R:F146	R:R:M143	30.5854	13.68	No	No	0	5	6
66	R:R:F146	R:R:H152	32.1203	6.79	No	No	0	5	5
67	R:R:F148	R:R:H152	35.3006	5.66	No	No	0	7	5
68	R:R:E134	R:R:F148	36.8724	11.66	No	No	0	8	7
69	R:R:F261	R:R:L216	15.3745	2.44	Yes	Yes	1	9	7
70	R:R:M257	R:R:Y223	26.9673	10.78	Yes	No	0	8	9
71	R:R:V254	R:R:Y223	23.27	7.57	No	No	0	8	9
72	R:R:V250	R:R:V254	19.4568	1.6	No	No	0	8	8
73	R:R:V230	R:R:V250	15.6857	4.81	No	No	0	8	8
74	R:R:E247	R:R:V230	13.8291	1.43	No	No	0	7	8
75	R:R:F283	R:R:I275	11.4399	5.02	Yes	No	1	4	4
76	R:R:I275	R:R:Y192	14.5675	2.42	No	Yes	1	4	5
77	R:R:I189	R:R:Y178	73.3386	4.84	Yes	Yes	1	4	3
78	L:L:?1	R:R:Y268	16.0338	20.27	Yes	Yes	1	0	6
79	R:R:S298	R:R:Y301	10.1582	3.82	No	Yes	1	9	5
80	R:R:L128	R:R:Y306	17.8534	16.41	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F91	R:R:M44	4.98	1	Yes	No	7	7	2	2
R:R:K296	R:R:M44	4.32	1	No	No	7	7	1	2
R:R:F91	R:R:K296	9.93	1	Yes	No	7	7	2	1
L:L:?1	R:R:A117	3.14	1	Yes	No	0	5	0	1
R:R:T118	R:R:Y178	4.99	1	No	Yes	4	3	2	2
R:R:I189	R:R:T118	4.56	1	Yes	No	4	4	1	2
R:R:E122	R:R:W126	7.63	1	Yes	Yes	6	5	1	2
R:R:C167	R:R:E122	12.15	1	No	Yes	5	6	2	1
R:R:E122	R:R:H211	11.08	1	Yes	Yes	6	6	1	2
L:L:?1	R:R:E122	3.52	1	Yes	Yes	0	6	0	1
R:R:F261	R:R:L125	4.87	1	Yes	No	9	7	2	2
R:R:L125	R:R:W265	20.5	1	No	Yes	7	8	2	1
R:R:H211	R:R:W126	8.46	1	Yes	Yes	6	5	2	2
R:R:C167	R:R:M207	3.24	1	No	Yes	5	5	2	1
R:R:C167	R:R:H211	7.37	1	No	Yes	5	6	2	2
R:R:P171	R:R:Y178	18.08	1	Yes	Yes	5	3	2	2
R:R:I189	R:R:P171	5.08	1	Yes	Yes	4	5	1	2
R:R:I189	R:R:Y178	4.84	1	Yes	Yes	4	3	1	2
R:R:F203	R:R:I189	5.02	1	Yes	Yes	6	4	2	1
R:R:I189	R:R:M207	2.92	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:I189	3.8	1	Yes	Yes	0	4	0	1
R:R:Y191	R:R:Y268	3.97	1	Yes	Yes	6	6	2	1
R:R:F203	R:R:Y206	4.13	1	Yes	Yes	6	4	2	2
R:R:F203	R:R:M207	12.44	1	Yes	Yes	6	5	2	1
R:R:M207	R:R:Y206	3.59	1	Yes	Yes	5	4	1	2
R:R:H211	R:R:Y206	4.36	1	Yes	Yes	6	4	2	2
R:R:H211	R:R:M207	3.94	1	Yes	Yes	6	5	2	1
L:L:?1	R:R:M207	8.46	1	Yes	Yes	0	5	0	1
R:R:F261	R:R:W265	9.02	1	Yes	Yes	9	8	2	1
R:R:C264	R:R:W265	6.53	1	No	Yes	8	8	2	1
R:R:W265	R:R:Y268	3.86	1	Yes	Yes	8	6	1	1
L:L:?1	R:R:W265	3.79	1	Yes	Yes	0	8	0	1
R:R:P291	R:R:Y268	8.34	0	No	Yes	6	6	2	1
R:R:A295	R:R:Y268	5.34	0	No	Yes	8	6	2	1
L:L:?1	R:R:Y268	20.27	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K296	10.31	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6OYA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	288
Number of Links	331
Number of Hubs	47
Number of Links mediated by Hubs	174
Number of Communities	8
Number of Nodes involved in Communities	78
Number of Links involved in Communities	108

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	50607
Length Of Smallest Path	3
Average Path Length	13.9603
Length of Longest Path	30
Minimum Path Strength	1.47
Average Path Strength	6.10385
Maximum Path Strength	17.865
Minimum Path Correlation	0.7
Average Path Correlation	0.936247
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	55.9717
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6517
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• guanyl nucleotide binding • binding • nucleotide binding • GDP binding • guanyl ribonucleotide binding • purine ribonucleotide binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • kinase binding • enzyme binding • protein kinase binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • acyl binding • GTP binding • purine ribonucleoside triphosphate binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • detection of light stimulus involved in visual perception • detection of light stimulus • response to light stimulus • multicellular organismal process • detection of external stimulus • sensory perception of light stimulus • system process • nervous system process • response to stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of light stimulus involved in sensory perception
Gene Ontology	Biological Process	• detection of light stimulus involved in visual perception • detection of light stimulus • response to light stimulus • multicellular organismal process • detection of external stimulus • sensory perception of light stimulus • system process • nervous system process • response to stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of light stimulus involved in sensory perception • response to abiotic stimulus • response to radiation • visual perception • detection of stimulus involved in sensory perception • phototransduction • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • detection of visible light • cell communication • cellular process • signal transduction • phototransduction, visible light • negative regulation of hydrolase activity • regulation of molecular function • regulation of catalytic activity • regulation of hydrolase activity • negative regulation of cyclic-nucleotide phosphodiesterase activity • negative regulation of molecular function • negative regulation of catalytic activity • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • membrane-bounded organelle • non-motile cilium • membrane • plasma membrane • cilium • 9+0 non-motile cilium • neuron projection • ciliary membrane • photoreceptor outer segment membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell periphery • cell projection • bounding membrane of organelle
Gene Ontology	Cellular Component	• membrane-bounded organelle • non-motile cilium • membrane • plasma membrane • cilium • 9+0 non-motile cilium • neuron projection • ciliary membrane • photoreceptor outer segment membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell periphery • cell projection • bounding membrane of organelle • cellular anatomical structure • photoreceptor cell cilium • organelle • plasma membrane region • organelle membrane • cell projection membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • photoreceptor disc membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • receptor complex • intracellular anatomical structure • cytoplasm • protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • G-protein beta-subunit binding • protein localization • localization • cellular localization • cellular macromolecule localization • macromolecule localization • cellular developmental process • photoreceptor cell differentiation • cell development • eye morphogenesis • neurogenesis • neuron differentiation • cell differentiation • eye photoreceptor cell differentiation • animal organ morphogenesis • photoreceptor cell development • eye photoreceptor cell development • nervous system development • generation of neurons • anatomical structure morphogenesis • sensory organ morphogenesis • neuron development • phototransduction • detection of light stimulus • response to light stimulus • detection of external stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • opsin binding • arrestin family protein binding • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • vitamin binding • retinal binding • isoprenoid binding • retinoid binding • lipid binding • 11-cis retinal binding • small molecule binding • G-protein alpha-subunit binding • enzyme regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • GDP binding • purine ribonucleotide binding • ion binding • anion binding • molecular function regulator activity • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • nucleoside-triphosphatase regulator activity • GTPase regulator activity • purine ribonucleoside triphosphate binding • guanyl-nucleotide exchange factor activity • nucleoside phosphate binding • purine nucleotide binding • cation binding • transition metal ion binding • zinc ion binding • metal ion binding • identical protein binding • rod bipolar cell differentiation • neural retina development • camera-type eye morphogenesis • retinal bipolar neuron differentiation • glutamatergic neuron differentiation • retina morphogenesis in camera-type eye • cellular response to light stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • detection of visible light • G protein-coupled opsin signaling pathway • phototransduction, visible light • response to light intensity • podosome assembly • organelle assembly • protein-containing complex organization • membraneless organelle assembly • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • protein-containing complex assembly • cellular component organization or biogenesis • biosynthetic process • metabolic process • macromolecule metabolic process • gene expression • macromolecule biosynthetic process • multicellular organismal-level homeostasis • homeostatic process • anatomical structure homeostasis • tissue homeostasis • retina homeostasis • photoreceptor cell maintenance • absorption of visible light • light absorption • microtubule cytoskeleton organization • microtubule-based process • cytoskeleton organization • sensory perception of light stimulus • visual perception • thermoception • sensory perception of temperature stimulus • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of temperature stimulus involved in thermoception • detection of temperature stimulus • detection of stimulus involved in sensory perception • taxis • thermotaxis • locomotion • cell-cell junction • anchoring junction • sperm midpiece • 9+2 motile cilium • sperm flagellum • motile cilium • photoreceptor inner segment membrane • Golgi membrane • Golgi apparatus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • outer membrane • sperm head • sperm head plasma membrane • sperm plasma membrane • rod photoreceptor outer segment
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	RET
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	RET
Name	RETINAL
Synonyms
Identifier
Formula	C20 H28 O
Molecular Weight	284.436
SMILES
PubChem	638015
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P02699
Sequence	>6OYA_nogp_Chain_R M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H K K L R T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G Y F V F G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K P M S N F R F G E N H A I M G V A F T W V M A L A C A A P P L V G W S R Y I P E G M Q C S C G I D Y Y T P H E E T N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q Q E S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H Q G S D F G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q F R N C M V T T L C C G K N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8P15	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.9	2024-11-20	To be published
	8P15 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.9	2024-11-20	To be published
	8P13	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.2	2024-11-20	To be published
	8P13 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.2	2024-11-20	To be published
	8P12	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	3.21	2024-11-20	To be published
	8P12 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.21	2024-11-20	To be published
	9EPR	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-	Gi1/β1/γ2	4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-		4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPQ	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.15	2024-10-23	10.1038/s41467-024-53208-2
	9EPQ (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.15	2024-10-23	10.1038/s41467-024-53208-2
	9EPP	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.06	2024-10-23	10.1038/s41467-024-53208-2
	9EPP (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.06	2024-10-23	10.1038/s41467-024-53208-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	10.1038/s41467-023-40911-9
	8FD1 (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		4.25	2023-08-30	10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	10.1038/s41467-023-40911-9
	8FD0 (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.71	2023-08-30	10.1038/s41467-023-40911-9
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	10.1038/s41467-023-40911-9
	8FCZ (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-		3.7	2023-08-30	10.1038/s41467-023-40911-9
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4	2021-07-07	10.1038/s41586-021-03721-x
	7MTB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4	2021-07-07	10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4.1	2021-07-07	10.1038/s41586-021-03721-x
	7MTA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.1	2021-07-07	10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	7	2021-07-07	10.1038/s41586-021-03721-x
	7MT9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		7	2021-07-07	10.1038/s41586-021-03721-x
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	5.8	2021-07-07	10.1038/s41586-021-03721-x
	7MT8 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		5.8	2021-07-07	10.1038/s41586-021-03721-x
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol		2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol		2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PEL (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol		3.19	2020-06-24	To be published
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6NWE (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		2.71	2020-02-12	To be published
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	10.1074/jbc.RA119.010089
	6OFJ (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		4.5	2019-08-21	10.1074/jbc.RA119.010089
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.3	2019-07-24	10.1016/j.molcel.2019.06.007
	6OYA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2019-07-24	10.1016/j.molcel.2019.06.007
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.9	2019-07-24	10.1016/j.molcel.2019.06.007
	6OY9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.9	2019-07-24	10.1016/j.molcel.2019.06.007
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gi1/β1/γ1	4.38	2019-07-10	10.7554/eLife.46041
	6QNO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.38	2019-07-10	10.7554/eLife.46041
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	10.1073/pnas.1902192116
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Go	3.12	2018-10-03	10.1126/sciadv.aat7052
	6FUF (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.12	2018-10-03	10.1126/sciadv.aat7052
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/β1/γ2	4.5	2018-06-20	10.1038/s41586-018-0215-y
	6CMO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-		4.5	2018-06-20	10.1038/s41586-018-0215-y
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	10.1073/pnas.1718084115
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	10.1073/pnas.1718084115
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	10.1038/nprot.2017.135
	5WKT (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		3.2	2017-12-13	10.1038/nprot.2017.135
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	10.1016/j.cell.2017.07.002
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	10.1073/pnas.1617446114
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	-	2.7	2017-03-15	10.1073/pnas.1617446114
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.3	2016-08-10	10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	10.15252/embr.201642671
	5EN0 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.81	2016-08-10	10.15252/embr.201642671
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	10.1038/sdata.2016.21
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	10.1016/j.str.2015.09.015
	4X1H (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-		2.29	2015-11-04	10.1016/j.str.2015.09.015
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	10.1038/nature14656
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2015-06-17	10.1371/journal.pone.0126970
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Arrestin1 Finger Loop	2.75	2014-09-17	10.1038/ncomms5801
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	10.1002/anie.201302374
	4J4Q (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-		2.65	2013-10-30	10.1002/anie.201302374
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	10.1038/embor.2013.44
	4BEY (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2013-05-08	10.1038/embor.2013.44
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	10.1038/embor.2013.44
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	10.1073/pnas.1114089108
	4A4M (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2012-01-25	10.1073/pnas.1114089108
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	10.1016/j.jmb.2011.08.044
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2011-08-17	10.1016/j.jmb.2011.08.044
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	10.1038/nature09795
	2X72 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3	2011-03-16	10.1038/nature09795
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	3	2011-03-09	10.1038/nature09789
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	10.1038/nature09789
	3PQR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.85	2011-03-09	10.1038/nature09789
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	10.1016/j.bpj.2010.08.003
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	10.1038/nature07330
	3DQB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.2	2008-09-23	10.1038/nature07330
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	10.1107/S0907444908017162
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	10.1107/S0907444908017162
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	10.1038/nature07063
	3CAP (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2008-06-24	10.1038/nature07063
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	10.1038/nature06925
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	10.1074/jbc.C800040200
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	10.1529/biophysj.107.108225
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	10.1016/j.jmb.2007.03.007
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	10.1073/pnas.0608022103
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	10.1073/pnas.0608022103
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.6	2006-09-02	10.1002/anie.200600595
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.8	2006-08-22	10.1073/pnas.0601765103
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	10.1016/j.jmb.2004.07.044
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	10.1016/j.jmb.2004.08.090
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	10.1073/pnas.082666399
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	10.1021/bi0155091
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	10.1126/science.289.5480.739

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6OYA_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.