psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D282	R:R:N2	13.46	No	No	4	2	6
2	H:H:?4	R:R:N2	30.7	Yes	No	4	0	6
3	R:R:N15	R:R:T4	2.92	Yes	No	2	7	6
4	R:R:T4	R:R:V20	9.52	No	No	2	6	6
5	R:R:E5	R:R:G6	3.27	No	No	0	6	6
6	R:R:G6	R:R:P7	4.06	No	No	2	6	6
7	R:R:F9	R:R:G6	7.53	Yes	No	2	7	6
8	R:R:F9	R:R:P7	8.67	Yes	No	2	7	6
9	R:R:N8	R:R:P107	4.89	No	No	0	4	3
10	R:R:F9	R:R:S22	7.93	Yes	Yes	2	7	5
11	R:R:F9	R:R:P23	7.22	Yes	Yes	2	7	5
12	R:R:Y10	R:R:Y192	2.98	No	Yes	0	7	5
13	R:R:T193	R:R:Y10	3.75	Yes	No	0	5	7
14	R:R:P12	R:R:V11	3.53	No	Yes	0	8	8
15	R:R:Q28	R:R:V11	2.87	Yes	Yes	2	5	8
16	R:R:L31	R:R:V11	4.47	Yes	Yes	2	4	8
17	R:R:Q184	R:R:V11	4.3	No	Yes	0	3	8
18	R:R:F13	R:R:T17	3.89	No	No	0	4	6
19	R:R:F13	R:R:Y30	6.19	No	Yes	0	4	4
20	R:R:K16	R:R:S14	9.18	No	No	0	7	4
21	R:R:G18	R:R:N15	3.39	No	Yes	2	3	7
22	R:R:N15	R:R:V20	8.87	Yes	No	2	7	6
23	H:H:?1	R:R:N15	29.47	No	Yes	2	0	7
24	H:H:?1	R:R:G18	3.06	No	No	2	0	3
25	R:R:V19	R:R:Y30	5.05	No	Yes	0	3	4
26	R:R:V20	R:R:Y30	11.36	No	Yes	2	6	4
27	R:R:R21	R:R:Y30	4.12	No	Yes	0	4	4
28	R:R:P23	R:R:S22	5.34	Yes	Yes	2	5	5
29	R:R:F24	R:R:S22	3.96	Yes	Yes	2	5	5
30	R:R:E25	R:R:S22	2.87	No	Yes	2	7	5
31	R:R:F24	R:R:P23	8.67	Yes	Yes	2	5	5
32	R:R:P23	R:R:Q28	7.9	Yes	Yes	2	5	5
33	R:R:P23	R:R:Q184	4.74	Yes	No	0	5	3
34	R:R:E25	R:R:F24	3.5	No	Yes	2	7	5
35	R:R:F24	R:R:G106	3.01	Yes	No	2	5	8
36	R:R:F24	R:R:P107	8.67	Yes	No	2	5	3
37	R:R:P27	R:R:Y29	5.56	No	No	0	8	4
38	R:R:Q28	R:R:Y30	12.4	Yes	Yes	2	5	4
39	R:R:L31	R:R:Q28	7.99	Yes	Yes	2	4	5
40	R:R:P34	R:R:Y29	5.56	No	No	0	3	4
41	R:R:F37	R:R:Y29	3.09	No	No	0	5	4
42	R:R:L31	R:R:Y30	4.69	Yes	Yes	2	4	4
43	R:R:L31	R:R:P285	3.28	Yes	Yes	0	4	3
44	R:R:A32	R:R:F37	2.77	No	No	0	3	5
45	R:R:E33	R:R:P34	3.14	No	No	0	3	3
46	R:R:E33	R:R:W35	4.36	No	No	0	3	3
47	R:R:Q36	R:R:W35	4.38	No	No	0	2	3
48	R:R:I286	R:R:Q36	4.12	Yes	No	0	1	2
49	R:R:F37	R:R:M183	6.22	No	Yes	0	5	2
50	R:R:L40	R:R:S98	3	No	No	0	5	5
51	R:R:L40	R:R:M183	5.65	No	Yes	0	5	2
52	R:R:F293	R:R:L40	4.87	Yes	No	0	5	5
53	R:R:A41	R:R:S98	3.42	No	No	0	5	5
54	R:R:A41	R:R:L99	3.15	No	No	0	5	4
55	R:R:L47	R:R:Y43	7.03	Yes	No	3	7	4
56	R:R:F294	R:R:Y43	3.09	No	No	0	7	4
57	R:R:T297	R:R:Y43	3.75	Yes	No	3	6	4
58	R:R:L47	R:R:M44	4.24	Yes	Yes	3	7	7
59	R:R:F91	R:R:M44	6.22	Yes	Yes	3	7	7
60	R:R:M44	R:R:T94	4.52	Yes	No	3	7	7
61	R:R:F293	R:R:M44	4.98	Yes	Yes	3	5	7
62	R:R:F45	R:R:M49	6.22	No	No	0	3	5
63	R:R:F91	R:R:L47	12.18	Yes	Yes	3	7	7
64	R:R:L47	R:R:T297	2.95	Yes	Yes	3	7	6
65	R:R:F91	R:R:I48	5.02	Yes	No	0	7	6
66	R:R:I48	R:R:L95	4.28	No	No	0	6	6
67	R:R:L50	R:R:M49	4.24	No	No	0	5	5
68	R:R:L50	R:R:V300	2.98	No	No	0	5	7
69	R:R:F52	R:R:P53	4.33	Yes	No	0	6	4
70	R:R:F52	R:R:F56	7.5	Yes	No	0	6	4
71	R:R:F52	R:R:L84	3.65	Yes	No	0	6	7
72	R:R:F52	R:R:F88	8.57	Yes	No	0	6	4
73	R:R:I54	R:R:P303	5.08	No	No	0	8	9
74	R:R:A80	R:R:N55	3.13	No	No	0	9	9
75	R:R:D83	R:R:N55	13.46	No	No	0	9	9
76	R:R:L84	R:R:N55	2.75	No	No	0	7	9
77	R:R:L57	R:R:M317	4.24	No	Yes	0	6	6
78	R:R:Q64	R:R:Y60	3.38	No	No	0	5	3
79	R:R:M317	R:R:V61	3.04	Yes	No	0	6	7
80	R:R:T320	R:R:V61	3.17	No	No	0	5	7
81	R:R:L77	R:R:T62	7.37	No	No	0	5	7
82	R:R:H65	R:R:Q64	3.71	Yes	No	5	5	5
83	R:R:Q64	R:R:T320	4.25	No	No	5	5	5
84	R:R:H65	R:R:L68	3.86	Yes	Yes	5	5	7
85	R:R:C316	R:R:H65	5.9	No	Yes	5	5	5
86	R:R:H65	R:R:T320	8.21	Yes	No	5	5	5
87	R:R:K66	R:R:R69	9.9	No	No	0	6	6
88	R:R:L68	R:R:N73	8.24	Yes	Yes	0	7	8
89	R:R:C316	R:R:L68	7.94	No	Yes	5	5	7
90	R:R:N73	R:R:T70	10.24	Yes	No	0	8	7
91	R:R:E134	R:R:P71	4.72	No	Yes	6	8	6
92	R:R:F148	R:R:P71	2.89	No	Yes	6	7	6
93	R:R:L72	R:R:N73	4.12	No	Yes	0	8	8
94	R:R:L72	R:R:V250	2.98	No	Yes	7	8	8
95	R:R:L72	R:R:N310	6.87	No	No	7	8	8
96	R:R:N73	R:R:Y306	8.14	Yes	No	0	8	9
97	R:R:E150	R:R:Y74	10.1	No	Yes	0	2	5
98	R:R:A153	R:R:Y74	5.34	No	Yes	0	7	5
99	R:R:I154	R:R:Y74	8.46	No	Yes	0	3	5
100	R:R:I75	R:R:L76	2.85	No	No	0	7	8
101	R:R:I75	R:R:V130	4.61	No	No	0	7	7
102	R:R:I75	R:R:L131	9.99	No	No	0	7	9
103	R:R:L76	R:R:Y306	17.58	No	No	0	8	9
104	R:R:N78	R:R:V157	10.35	No	No	0	9	7
105	R:R:N78	R:R:T160	5.85	No	No	0	9	7
106	R:R:N78	R:R:W161	7.91	No	No	0	9	9
107	R:R:L79	R:R:S127	3	No	No	0	9	8
108	R:R:L79	R:R:N302	4.12	No	Yes	0	9	9
109	R:R:A82	R:R:I123	4.87	No	Yes	0	8	7
110	R:R:A299	R:R:D83	6.18	No	No	0	9	9
111	R:R:D83	R:R:N302	5.39	No	Yes	0	9	9
112	R:R:G120	R:R:M86	3.49	No	No	0	8	7
113	R:R:K296	R:R:M86	4.32	No	No	0	7	7
114	R:R:M86	R:R:S298	3.07	No	No	0	7	9
115	R:R:F91	R:R:V87	3.93	Yes	No	0	7	6
116	R:R:F116	R:R:G89	3.01	No	No	0	4	4
117	R:R:E113	R:R:T93	5.64	Yes	No	0	5	5
118	R:R:E113	R:R:T94	5.64	Yes	No	0	5	7
119	R:R:F293	R:R:T94	3.89	Yes	No	3	5	7
120	R:R:L95	R:R:L99	4.15	No	No	0	6	4
121	R:R:H100	R:R:Y96	7.62	No	No	0	4	4
122	R:R:V104	R:R:Y96	6.31	No	No	0	4	4
123	R:R:F105	R:R:Y96	4.13	No	No	0	7	4
124	R:R:F103	R:R:T97	5.19	No	No	0	8	5
125	R:R:C185	R:R:T97	6.76	No	No	0	5	5
126	R:R:H100	R:R:Y102	3.27	No	No	0	4	4
127	R:R:V104	R:R:Y102	10.09	No	No	0	4	4
128	R:R:C110	R:R:F103	2.79	No	No	8	9	8
129	R:R:C187	R:R:F103	8.38	Yes	No	8	9	8
130	R:R:G106	R:R:P107	4.06	No	No	2	8	3
131	R:R:C110	R:R:C187	7.28	No	Yes	8	9	9
132	R:R:N111	R:R:Y178	4.65	No	Yes	0	7	3
133	R:R:E113	R:R:S186	2.87	Yes	No	0	5	5
134	R:R:C187	R:R:E113	6.08	Yes	Yes	0	9	5
135	R:R:E113	R:R:K296	5.4	Yes	No	0	5	7
136	R:R:G114	R:R:Y178	10.14	No	Yes	0	5	3
137	R:R:F115	R:R:F116	4.29	Yes	No	0	6	4
138	R:R:F115	R:R:L119	3.65	Yes	No	0	6	5
139	R:R:A168	R:R:F115	2.77	No	Yes	0	7	6
140	R:R:F115	R:R:L172	3.65	Yes	No	0	6	5
141	R:R:A117	R:R:K296	3.21	No	No	0	5	7
142	R:R:E122	R:R:T118	2.82	No	No	0	6	4
143	R:R:T118	R:R:Y178	7.49	No	Yes	0	4	3
144	R:R:I123	R:R:L119	2.85	Yes	No	0	7	5
145	R:R:C167	R:R:E122	9.12	No	No	0	5	6
146	R:R:L125	R:R:P215	9.85	No	Yes	0	7	9
147	R:R:M163	R:R:W126	11.63	No	No	0	4	5
148	R:R:H211	R:R:W126	8.46	No	No	0	6	5
149	R:R:P215	R:R:W126	4.05	Yes	No	0	9	5
150	R:R:S127	R:R:T160	7.99	No	No	0	8	7
151	R:R:L128	R:R:L131	4.15	No	No	0	8	9
152	R:R:A132	R:R:I219	3.25	No	No	0	9	8
153	R:R:C222	R:R:I133	3.27	No	No	0	8	6
154	R:R:E134	R:R:F148	10.49	No	No	6	8	7
155	R:R:R135	R:R:T251	7.76	No	No	0	9	6
156	R:R:C140	R:R:Y136	6.72	No	Yes	0	7	7
157	R:R:C222	R:R:Y136	5.38	No	Yes	0	8	7
158	R:R:Q225	R:R:Y136	14.65	No	Yes	0	4	7
159	R:R:L226	R:R:Y136	3.52	No	Yes	0	8	7
160	R:R:L226	R:R:V139	4.47	No	No	0	8	8
161	R:R:T229	R:R:V139	4.76	No	No	0	6	8
162	R:R:K141	R:R:P142	3.35	No	No	0	6	8
163	R:R:M143	R:R:P142	5.03	No	No	0	6	8
164	R:R:F146	R:R:M143	4.98	No	No	0	5	6
165	R:R:F146	R:R:H152	7.92	No	No	0	5	5
166	R:R:F148	R:R:H152	3.39	No	No	0	7	5
167	R:R:H152	R:R:N151	5.1	No	No	0	5	4
168	R:R:I154	R:R:M155	4.37	No	No	0	3	2
169	R:R:C167	R:R:H211	16.22	No	No	0	5	6
170	R:R:P170	R:R:P171	5.84	No	Yes	1	7	5
171	R:R:F203	R:R:P170	8.67	Yes	No	1	6	7
172	R:R:P171	R:R:Y178	13.91	Yes	Yes	1	5	3
173	R:R:I189	R:R:P171	5.08	Yes	Yes	1	4	5
174	R:R:F203	R:R:P171	2.89	Yes	Yes	1	6	5
175	R:R:S202	R:R:W175	4.94	No	No	0	4	5
176	R:R:F203	R:R:W175	11.02	Yes	No	0	6	5
177	R:R:N200	R:R:S176	7.45	Yes	No	0	4	5
178	R:R:F203	R:R:S176	5.28	Yes	No	0	6	5
179	R:R:D190	R:R:R177	10.72	Yes	No	1	4	5
180	R:R:R177	R:R:T193	5.17	No	Yes	1	5	5
181	R:R:H195	R:R:R177	21.44	Yes	No	1	4	5
182	R:R:I189	R:R:Y178	6.04	Yes	Yes	1	4	3
183	R:R:I179	R:R:P180	5.08	No	No	0	1	3
184	R:R:D190	R:R:I179	2.8	Yes	No	0	4	1
185	R:R:P180	R:R:Q184	12.63	No	No	0	3	3
186	R:R:C187	R:R:P180	3.77	Yes	No	0	9	3
187	R:R:E181	R:R:S186	7.19	Yes	No	0	4	5
188	R:R:E181	R:R:G188	6.55	Yes	No	0	4	5
189	R:R:E181	R:R:Y191	4.49	Yes	Yes	1	4	6
190	R:R:E181	R:R:Y192	4.49	Yes	Yes	1	4	5
191	R:R:E181	R:R:Y268	6.73	Yes	Yes	1	4	6
192	R:R:E181	R:R:M288	4.06	Yes	Yes	1	4	4
193	R:R:I286	R:R:M183	2.92	Yes	Yes	0	1	2
194	R:R:M183	R:R:T289	7.53	Yes	No	0	2	4
195	R:R:F293	R:R:S186	3.96	Yes	No	0	5	5
196	R:R:I189	R:R:Y191	3.63	Yes	Yes	1	4	6
197	R:R:F203	R:R:I189	5.02	Yes	Yes	1	6	4
198	R:R:I189	R:R:M207	5.83	Yes	No	0	4	5
199	R:R:D190	R:R:Y192	4.6	Yes	Yes	1	4	5
200	R:R:D190	R:R:T193	13.01	Yes	Yes	1	4	5
201	R:R:D190	R:R:N200	10.77	Yes	Yes	1	4	4
202	R:R:Y191	R:R:Y192	8.94	Yes	Yes	1	6	5
203	R:R:Y191	R:R:Y268	7.94	Yes	Yes	1	6	6
204	R:R:M288	R:R:Y191	3.59	Yes	Yes	1	4	6
205	R:R:I275	R:R:Y192	3.63	Yes	Yes	1	4	5
206	R:R:F283	R:R:Y192	4.13	Yes	Yes	1	4	5
207	R:R:M288	R:R:Y192	3.59	Yes	Yes	1	4	5
208	R:R:P194	R:R:T193	3.5	No	Yes	0	1	5
209	R:R:E197	R:R:H195	6.15	No	Yes	0	3	4
210	R:R:H195	R:R:T198	10.95	Yes	No	1	4	1
211	R:R:H195	R:R:N200	5.1	Yes	Yes	1	4	4
212	R:R:N200	R:R:T198	2.92	Yes	No	1	4	1
213	R:R:N199	R:R:S202	4.47	No	No	0	3	4
214	R:R:F203	R:R:Y206	4.13	Yes	Yes	0	6	4
215	R:R:F276	R:R:V204	13.11	No	No	0	4	4
216	R:R:V210	R:R:Y206	6.31	No	Yes	0	4	4
217	R:R:H211	R:R:Y206	15.24	No	Yes	0	6	4
218	R:R:F208	R:R:F273	5.36	No	No	0	5	6
219	R:R:A269	R:R:F212	4.16	No	No	0	7	8
220	R:R:I214	R:R:P215	6.77	No	Yes	0	5	9
221	R:R:K248	R:R:T229	3	No	No	0	4	6
222	R:R:E239	R:R:Q244	11.47	No	No	0	2	4
223	R:R:A241	R:R:Q244	7.58	No	No	0	3	4
224	R:R:K248	R:R:Q244	8.14	No	No	0	4	4
225	R:R:E247	R:R:V250	8.56	No	Yes	0	7	8
226	R:R:E249	R:R:V250	5.7	No	Yes	0	7	8
227	R:R:N310	R:R:V250	8.87	No	Yes	7	8	8
228	R:R:M253	R:R:M257	2.89	No	No	0	8	8
229	R:R:M253	R:R:M309	10.11	No	Yes	0	8	7
230	R:R:M253	R:R:N310	8.41	No	No	0	8	8
231	R:R:I256	R:R:I305	5.89	No	No	9	5	8
232	R:R:I256	R:R:M309	2.92	No	Yes	9	5	7
233	R:R:I305	R:R:M257	2.92	No	No	0	8	8
234	R:R:F261	R:R:W265	11.02	No	No	0	9	8
235	R:R:F261	R:R:Y301	3.09	No	Yes	0	9	5
236	R:R:C264	R:R:T297	3.38	No	Yes	3	8	6
237	R:R:C264	R:R:Y301	4.03	No	Yes	3	8	5
238	R:R:A295	R:R:W265	9.08	No	No	0	8	8
239	R:R:S298	R:R:W265	4.94	No	No	0	9	8
240	R:R:M288	R:R:Y268	7.18	Yes	Yes	1	4	6
241	R:R:P291	R:R:Y268	4.17	No	Yes	0	6	6
242	R:R:A292	R:R:Y268	4	No	Yes	0	5	6
243	R:R:F287	R:R:V271	11.8	Yes	No	0	4	5
244	R:R:F273	R:R:T277	7.78	No	No	0	6	5
245	R:R:H278	R:R:Y274	25.04	No	No	0	3	4
246	R:R:F287	R:R:Y274	4.13	Yes	No	0	4	4
247	R:R:F283	R:R:I275	13.82	Yes	Yes	1	4	4
248	R:R:F287	R:R:I275	5.02	Yes	Yes	1	4	4
249	R:R:I275	R:R:M288	4.37	Yes	Yes	1	4	4
250	R:R:H278	R:R:T277	5.48	No	No	0	3	5
251	H:H:?5	R:R:H278	3.45	No	No	0	0	3
252	H:H:?4	R:R:S281	4.03	Yes	No	4	0	4
253	H:H:?5	R:R:S281	4.03	No	No	4	0	4
254	H:H:?4	R:R:D282	4.85	Yes	No	4	0	2
255	R:R:F283	R:R:F287	7.5	Yes	Yes	1	4	4
256	R:R:G284	R:R:P285	4.06	No	Yes	0	4	3
257	R:R:I286	R:R:P285	5.08	Yes	Yes	0	1	3
258	R:R:I286	R:R:I290	2.94	Yes	No	0	1	5
259	R:R:I290	R:R:P291	3.39	No	No	0	5	6
260	R:R:T297	R:R:Y301	3.75	Yes	Yes	3	6	5
261	R:R:N302	R:R:Y301	5.81	Yes	Yes	0	9	5
262	R:R:N302	R:R:P303	3.26	Yes	No	0	9	9
263	R:R:I305	R:R:M309	2.92	No	Yes	9	8	7
264	R:R:I307	R:R:M317	4.37	No	Yes	0	7	6
265	R:R:C323	R:R:G324	3.92	No	No	0	9	3
266	R:R:N326	R:R:P327	4.89	No	No	0	3	5
267	H:H:?1	H:H:?2	34.31	No	No	0	0	0
268	H:H:?2	H:H:?3	30.56	No	No	0	0	0
269	H:H:?4	H:H:?5	30.99	Yes	No	4	0	0
270	R:R:H65	R:R:T319	2.74	Yes	No	0	5	4
271	R:R:A272	R:R:Y191	2.67	No	Yes	0	5	6
272	R:R:A260	R:R:Y301	2.67	No	Yes	0	7	5
273	R:R:F159	R:R:V130	2.62	No	No	0	3	7
274	R:R:R135	R:R:V250	2.62	No	Yes	0	9	8
275	R:R:F208	R:R:V204	2.62	No	No	0	5	4
276	R:R:I307	R:R:R314	2.51	No	No	0	7	8
277	R:R:F159	R:R:M163	2.49	No	No	0	3	4
278	R:R:M309	R:R:R252	2.48	Yes	No	0	7	7
279	R:R:V81	R:R:W161	2.45	No	No	0	6	9
280	R:R:F212	R:R:L216	2.44	No	No	0	8	7
281	R:R:F261	R:R:L262	2.44	No	No	0	9	6
282	R:R:N315	R:R:R314	2.41	No	No	0	5	8
283	R:R:I123	R:R:W161	2.35	Yes	No	0	7	9
284	R:R:E134	R:R:R135	2.33	No	No	0	8	9
285	R:R:G89	R:R:G90	2.11	No	No	0	4	6
286	R:R:G120	R:R:G121	2.11	No	No	0	8	7
287	R:R:R69	R:R:Y74	2.06	No	Yes	0	6	5
288	R:R:G51	R:R:P53	2.03	No	No	0	8	4
289	R:R:G149	R:R:P71	2.03	No	Yes	0	6	6
290	R:R:G182	R:R:P285	2.03	No	Yes	0	3	3
291	R:R:P267	R:R:P291	1.95	No	No	0	9	6
292	R:R:A269	R:R:G270	1.95	No	No	0	7	5
293	R:R:A26	R:R:P27	1.87	No	No	0	2	8
294	R:R:A153	R:R:P71	1.87	No	Yes	0	7	6
295	R:R:A169	R:R:P170	1.87	No	No	0	3	7
296	R:R:G51	R:R:V300	1.84	No	No	0	8	7
297	R:R:G156	R:R:V130	1.84	No	No	0	6	7
298	R:R:G224	R:R:V227	1.84	No	No	0	3	5
299	R:R:G3	R:R:T4	1.82	No	No	0	6	6
300	R:R:G89	R:R:T92	1.82	No	No	0	4	8
301	R:R:G109	R:R:T108	1.82	No	No	0	5	1
302	R:R:C322	R:R:C323	1.82	No	No	0	4	9
303	R:R:A132	R:R:C222	1.81	No	No	0	9	8
304	R:R:P215	R:R:V129	1.77	Yes	No	0	9	7
305	R:R:P142	R:R:V137	1.77	No	No	0	8	4
306	R:R:G109	R:R:L112	1.71	No	No	0	5	4
307	R:R:C264	R:R:I263	1.64	No	No	0	8	5
308	R:R:L266	R:R:P267	1.64	No	No	0	6	9
309	R:R:A164	R:R:I123	1.62	No	Yes	0	8	7
310	R:R:C322	R:R:K325	1.62	No	No	0	4	3
311	R:R:V129	R:R:V218	1.6	No	No	0	7	6
312	R:R:V254	R:R:V258	1.6	No	No	0	8	8
313	R:R:G101	R:R:H100	1.59	No	No	0	4	4
314	R:R:A124	R:R:L79	1.58	No	No	0	9	9
315	R:R:A169	R:R:L165	1.58	No	No	0	3	3
316	R:R:T58	R:R:T62	1.57	No	No	0	9	7
317	R:R:E196	R:R:P194	1.57	No	No	0	1	1
318	R:R:I133	R:R:V129	1.54	No	No	0	6	7
319	R:R:I133	R:R:V137	1.54	No	No	0	6	4
320	R:R:I214	R:R:V209	1.54	No	No	0	5	5
321	R:R:M308	R:R:V304	1.52	No	No	0	6	7
322	R:R:F105	R:R:G109	1.51	No	No	0	7	5
323	R:R:F283	R:R:G280	1.51	Yes	No	0	4	1
324	R:R:K325	R:R:T319	1.5	No	No	0	3	4
325	R:R:L59	R:R:V81	1.49	No	No	0	7	6
326	R:R:L128	R:R:V258	1.49	No	No	0	8	8
327	R:R:L262	R:R:V258	1.49	No	No	0	6	8
328	R:R:L68	R:R:T62	1.47	Yes	No	0	7	7
329	R:R:I213	R:R:I217	1.47	No	No	0	4	4
330	R:R:I255	R:R:I259	1.47	No	No	0	5	5
331	R:R:I259	R:R:I263	1.47	No	No	0	5	5
332	R:R:G224	R:R:Y223	1.45	No	No	0	3	9
333	R:R:L321	R:R:M317	1.41	No	Yes	0	6	6
334	R:R:L216	R:R:L262	1.38	No	No	0	7	6
335	R:R:A166	R:R:Y206	1.33	No	Yes	0	4	4
336	R:R:F85	R:R:V81	1.31	No	No	0	6	6
337	R:R:F221	R:R:I217	1.26	No	No	0	4	4
338	R:R:F45	R:R:L46	1.22	No	No	0	3	5
339	R:R:F116	R:R:L112	1.22	No	No	0	4	4
340	R:R:I255	R:R:Y223	1.21	No	No	0	5	9
341	R:R:E201	R:R:F276	1.17	No	No	0	3	4
342	R:R:M39	R:R:W35	1.16	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F9	7.8375	4	2	7
2	R:R:V11	3.7925	4	2	8
3	R:R:N15	11.1625	4	2	7
4	R:R:S22	5.025	4	2	5
5	R:R:P23	6.774	5	2	5
6	R:R:F24	5.562	5	2	5
7	R:R:Q28	7.79	4	2	5
8	R:R:Y30	7.30167	6	2	4
9	R:R:L31	5.1075	4	2	4
10	R:R:M44	4.99	4	3	7
11	R:R:L47	6.6	4	3	7
12	R:R:F52	6.0125	4	0	6
13	R:R:H65	4.884	5	5	5
14	R:R:L68	5.3775	4	5	7
15	R:R:P71	2.8775	4	6	6
16	R:R:N73	7.685	4	0	8
17	R:R:Y74	6.49	4	0	5
18	R:R:F91	6.8375	4	3	7
19	R:R:E113	5.126	5	0	5
20	R:R:F115	3.59	4	0	6
21	R:R:I123	2.9225	4	0	7
22	R:R:Y136	7.5675	4	0	7
23	R:R:P171	6.93	4	1	5
24	R:R:Y178	8.446	5	1	3
25	R:R:E181	5.585	6	1	4
26	R:R:M183	5.58	4	0	2
27	R:R:C187	6.3775	4	8	9
28	R:R:I189	5.12	5	1	4
29	R:R:D190	8.38	5	1	4
30	R:R:Y191	5.21	6	1	6
31	R:R:Y192	4.62286	7	1	5
32	R:R:T193	6.3575	4	1	5
33	R:R:H195	10.91	4	1	4
34	R:R:N200	6.56	4	1	4
35	R:R:F203	6.16833	6	1	6
36	R:R:Y206	6.7525	4	0	4
37	R:R:P215	5.61	4	0	9
38	R:R:V250	5.746	5	7	8
39	R:R:Y268	6.004	5	1	6
40	R:R:I275	6.71	4	1	4
41	R:R:F283	6.74	4	1	4
42	R:R:P285	3.6125	4	0	3
43	R:R:I286	3.765	4	0	1
44	R:R:F287	7.1125	4	1	4
45	R:R:M288	4.558	5	1	4
46	R:R:F293	4.425	4	3	5
47	R:R:T297	3.4575	4	3	6
48	R:R:Y301	3.87	5	3	5
49	R:R:N302	4.645	4	0	9
50	R:R:M309	4.6075	4	9	7
51	R:R:M317	3.265	4	0	6
52	H:H:?4	17.6425	4	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?4	H:H:?5	15.305	30.99	Yes	No	4	0	0
2	H:H:?5	R:R:H278	25.118	3.45	No	No	0	0	3
3	R:R:H278	R:R:Y274	60.3502	25.04	No	No	0	3	4
4	R:R:F287	R:R:Y274	65.3363	4.13	Yes	No	0	4	4
5	R:R:F287	R:R:I275	48.8828	5.02	Yes	Yes	1	4	4
6	R:R:I275	R:R:Y192	27.9663	3.63	Yes	Yes	1	4	5
7	R:R:D190	R:R:Y192	27.051	4.6	Yes	Yes	1	4	5
8	R:R:D190	R:R:I179	54.0963	2.8	Yes	No	0	4	1
9	R:R:I179	R:R:P180	54.1873	5.08	No	No	0	1	3
10	R:R:P180	R:R:Q184	77.6906	12.63	No	No	0	3	3
11	R:R:Q184	R:R:V11	38.5013	4.3	No	Yes	0	3	8
12	R:R:Q28	R:R:V11	17.5849	2.87	Yes	Yes	2	5	8
13	R:R:Q28	R:R:Y30	32.3554	12.4	Yes	Yes	2	5	4
14	R:R:V20	R:R:Y30	42.1513	11.36	No	Yes	2	6	4
15	R:R:N15	R:R:V20	26.1982	8.87	Yes	No	2	7	6
16	R:R:F283	R:R:F287	26.3858	7.5	Yes	Yes	1	4	4
17	R:R:F283	R:R:Y192	30.0927	4.13	Yes	Yes	1	4	5
18	R:R:P23	R:R:Q184	38.3137	4.74	Yes	No	0	5	3
19	R:R:P23	R:R:Q28	20.3025	7.9	Yes	Yes	2	5	5
20	R:R:L31	R:R:V11	18.2614	4.47	Yes	Yes	2	4	8
21	R:R:L31	R:R:Y30	36.0566	4.69	Yes	Yes	2	4	4
22	R:R:I275	R:R:M288	24.2652	4.37	Yes	Yes	1	4	4
23	R:R:P291	R:R:Y268	29.0864	4.17	No	Yes	0	6	6
24	R:R:I290	R:R:P291	24.8906	3.39	No	No	0	5	6
25	R:R:I286	R:R:I290	24.4414	2.94	Yes	No	0	1	5
26	R:R:I286	R:R:P285	29.7686	5.08	Yes	Yes	0	1	3
27	R:R:L31	R:R:P285	25.5046	3.28	Yes	Yes	0	4	3
28	R:R:T4	R:R:V20	10.6601	9.52	No	No	2	6	6
29	R:R:F24	R:R:P23	10.12	8.67	Yes	Yes	2	5	5
30	R:R:F13	R:R:Y30	10.7169	6.19	No	Yes	0	4	4
31	H:H:?1	R:R:N15	15.5836	29.47	No	Yes	2	0	7
32	R:R:E181	R:R:Y192	34.5273	4.49	Yes	Yes	1	4	5
33	R:R:E181	R:R:S186	72.6818	7.19	Yes	No	0	4	5
34	R:R:F293	R:R:S186	58.2921	3.96	Yes	No	0	5	5
35	R:R:F293	R:R:L40	37.9328	4.87	Yes	No	0	5	5
36	R:R:L40	R:R:M183	33.1116	5.65	No	Yes	0	5	2
37	R:R:F37	R:R:M183	15.9873	6.22	No	Yes	0	5	2
38	R:R:F37	R:R:Y29	11.0183	3.09	No	No	0	5	4
39	R:R:E181	R:R:M288	11.3651	4.06	Yes	Yes	1	4	4
40	R:R:I286	R:R:M183	23.998	2.92	Yes	Yes	0	1	2
41	R:R:F293	R:R:M44	69.9073	4.98	Yes	Yes	3	5	7
42	R:R:L47	R:R:M44	76.1101	4.24	Yes	Yes	3	7	7
43	R:R:L47	R:R:T297	77.7873	2.95	Yes	Yes	3	7	6
44	R:R:E113	R:R:S186	19.0858	2.87	Yes	No	0	5	5
45	R:R:E113	R:R:T94	13.5539	5.64	Yes	No	0	5	7
46	R:R:T297	R:R:Y301	71.9825	3.75	Yes	Yes	3	6	5
47	R:R:N302	R:R:Y301	80.5049	5.81	Yes	Yes	0	9	5
48	R:R:D83	R:R:N302	27.5399	5.39	No	Yes	0	9	9
49	R:R:D83	R:R:N55	24.015	13.46	No	No	0	9	9
50	R:R:L84	R:R:N55	20.4446	2.75	No	No	0	7	9
51	R:R:F52	R:R:L84	18.6423	3.65	Yes	No	0	6	7
52	R:R:F52	R:R:P53	13.1673	4.33	Yes	No	0	6	4
53	R:R:G51	R:R:P53	11.3196	2.03	No	No	0	8	4
54	R:R:Y191	R:R:Y192	24.6802	8.94	Yes	Yes	1	6	5
55	R:R:I189	R:R:Y191	78.8902	3.63	Yes	Yes	1	4	6
56	R:R:F203	R:R:I189	66.8543	5.02	Yes	Yes	1	6	4
57	R:R:F203	R:R:Y206	100	4.13	Yes	Yes	0	6	4
58	R:R:H211	R:R:Y206	96.7764	15.24	No	Yes	0	6	4
59	R:R:H211	R:R:W126	97.6804	8.46	No	No	0	6	5
60	R:R:M163	R:R:W126	62.3628	11.63	No	No	0	4	5
61	R:R:F159	R:R:M163	61.5953	2.49	No	No	0	3	4
62	R:R:F159	R:R:V130	60.9699	2.62	No	No	0	3	7
63	R:R:I75	R:R:V130	60.0375	4.61	No	No	0	7	7
64	R:R:I75	R:R:L76	94.3772	2.85	No	No	0	7	8
65	R:R:L76	R:R:Y306	92.4043	17.58	No	No	0	8	9
66	R:R:N73	R:R:Y306	90.386	8.14	Yes	No	0	8	9
67	R:R:L68	R:R:N73	50.9921	8.24	Yes	Yes	0	7	8
68	R:R:H65	R:R:L68	39.3598	3.86	Yes	Yes	5	5	7
69	R:R:H65	R:R:T320	19.9557	8.21	Yes	No	5	5	5
70	R:R:T320	R:R:V61	17.727	3.17	No	No	0	5	7
71	R:R:M317	R:R:V61	15.2311	3.04	Yes	No	0	6	7
72	R:R:M288	R:R:Y191	10.5179	3.59	Yes	Yes	1	4	6
73	R:R:P215	R:R:W126	62.4765	4.05	Yes	No	0	9	5
74	R:R:P215	R:R:V129	55.4039	1.77	Yes	No	0	9	7
75	R:R:I133	R:R:V129	51.9586	1.54	No	No	0	6	7
76	R:R:I133	R:R:V137	27.5513	1.54	No	No	0	6	4
77	R:R:P142	R:R:V137	25.9708	1.77	No	No	0	8	4
78	R:R:M143	R:R:P142	22.7983	5.03	No	No	0	6	8
79	R:R:F146	R:R:M143	21.2064	4.98	No	No	0	5	6
80	R:R:F146	R:R:H152	20.3991	7.92	No	No	0	5	5
81	R:R:F148	R:R:H152	19.1426	3.39	No	No	0	7	5
82	R:R:F148	R:R:P71	12.4794	2.89	No	Yes	6	7	6
83	R:R:A153	R:R:P71	15.8338	1.87	No	Yes	0	7	6
84	R:R:A153	R:R:Y74	13.6051	5.34	No	Yes	0	7	5
85	R:R:L72	R:R:N73	42.7824	4.12	No	Yes	0	8	8
86	R:R:L72	R:R:V250	22.1388	2.98	No	Yes	7	8	8
87	R:R:L72	R:R:N310	18.5627	6.87	No	No	7	8	8
88	R:R:I75	R:R:L131	65.4841	9.99	No	No	0	7	9
89	R:R:L79	R:R:N302	54.102	4.12	No	Yes	0	9	9
90	R:R:L79	R:R:S127	50.9409	3	No	No	0	9	8
91	R:R:S127	R:R:T160	49.3433	7.99	No	No	0	8	7
92	R:R:N78	R:R:T160	47.7344	5.85	No	No	0	9	7
93	R:R:N78	R:R:W161	44.4823	7.91	No	No	0	9	9
94	R:R:I123	R:R:W161	37.8418	2.35	Yes	No	0	7	9
95	R:R:E113	R:R:K296	35.8065	5.4	Yes	No	0	5	7
96	R:R:K296	R:R:M86	34.1634	4.32	No	No	0	7	7
97	R:R:M86	R:R:S298	31.8438	3.07	No	No	0	7	9
98	R:R:I123	R:R:L119	32.7421	2.85	Yes	No	0	7	5
99	R:R:F115	R:R:L119	31.0194	3.65	Yes	No	0	6	5
100	R:R:F115	R:R:F116	25.7832	4.29	Yes	No	0	6	4
101	R:R:F116	R:R:L112	18.6423	1.22	No	No	0	4	4
102	R:R:G109	R:R:L112	16.8287	1.71	No	No	0	5	4
103	R:R:F105	R:R:G109	13.1673	1.51	No	No	0	7	5
104	R:R:F105	R:R:Y96	11.3196	4.13	No	No	0	7	4
105	R:R:C187	R:R:E113	38.5639	6.08	Yes	Yes	0	9	5
106	R:R:C187	R:R:P180	34.5784	3.77	Yes	No	0	9	3
107	R:R:S298	R:R:W265	31.2582	4.94	No	No	0	9	8
108	R:R:F261	R:R:W265	30.7124	11.02	No	No	0	9	8
109	R:R:F261	R:R:L262	77.3893	2.44	No	No	0	9	6
110	R:R:L262	R:R:V258	69.5094	1.49	No	No	0	6	8
111	R:R:L128	R:R:V258	66.7463	1.49	No	No	0	8	8
112	R:R:F261	R:R:Y301	54.5398	3.09	No	Yes	0	9	5
113	R:R:C222	R:R:I133	27.3466	3.27	No	No	0	8	6
114	R:R:R135	R:R:V250	17.6872	2.62	No	Yes	0	9	8
115	R:R:C222	R:R:Y136	21.1382	5.38	No	Yes	0	8	7
116	R:R:L226	R:R:Y136	14.8274	3.52	No	Yes	0	8	7
117	R:R:L226	R:R:V139	12.7011	4.47	No	No	0	8	8
118	R:R:T229	R:R:V139	10.5634	4.76	No	No	0	6	8
119	R:R:D190	R:R:N200	43.5727	10.77	Yes	Yes	1	4	4
120	R:R:N200	R:R:S176	40.5708	7.45	Yes	No	0	4	5
121	R:R:H278	R:R:T277	30.5589	5.48	No	No	0	3	5
122	R:R:F273	R:R:T277	25.4932	7.78	No	No	0	6	5
123	R:R:F208	R:R:F273	20.4162	5.36	No	No	0	5	6
124	R:R:F208	R:R:V204	15.3278	2.62	No	No	0	5	4
125	R:R:F276	R:R:V204	10.228	13.11	No	No	0	4	4
126	R:R:L216	R:R:L262	10.9387	1.38	No	No	0	7	6
127	R:R:M253	R:R:N310	17.8634	8.41	No	No	0	8	8
128	R:R:M253	R:R:M309	10.2394	10.11	No	Yes	0	8	7
129	R:R:K325	R:R:T319	10.228	1.5	No	No	0	3	4
130	R:R:H65	R:R:T319	12.576	2.74	Yes	No	0	5	4
131	H:H:?1	H:H:?2	10.2564	34.31	No	No	0	0	0
132	R:R:C264	R:R:I263	11.2457	1.64	No	No	0	8	5
133	R:R:F203	R:R:S176	40.6447	5.28	Yes	No	0	6	5
134	R:R:L128	R:R:L131	65.5523	4.15	No	No	0	8	9
135	R:R:Y191	R:R:Y268	22.3151	7.94	Yes	Yes	1	6	6
136	R:R:M44	R:R:T94	11.0467	4.52	Yes	No	3	7	7
137	R:R:E134	R:R:R135	13.4516	2.33	No	No	0	8	9
138	R:R:E181	R:R:Y191	25.5671	4.49	Yes	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 2I37

PDB Summary
PDB	2I37
Class	A
SubFamily	Sensory
Type	Opsins
SubType	Rhodopsin
Species	Bos Taurus
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	4.15
Date	2006-10-17
D.O.I.	10.1073/pnas.0608022103

Net Summary
I_min	2.75
Number of Linked Nodes	297
Number of Links	342
Number of Hubs	52
Number of Links mediated by Hubs	180
Number of Communities	9
Number of Nodes involved in Communities	68
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	139
Number Of Links MetaPath	138
Number of Shortest Paths	65450
Length Of Smallest Path	3
Average Path Length	16.1213
Length of Longest Path	38
Minimum Path Strength	1.33
Average Path Strength	5.85156
Maximum Path Strength	32.435
Minimum Path Correlation	0.7
Average Path Correlation	0.947412
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	56.958
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.6561
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• opsin binding • protein binding • binding • arrestin family protein binding • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • vitamin binding • retinal binding • isoprenoid binding • retinoid binding • lipid binding • 11-cis retinal binding • small molecule binding • G-protein alpha-subunit binding • enzyme regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • hydrolase activity • guanyl ribonucleotide binding • GDP binding • purine ribonucleotide binding • ion binding • ribonucleoside triphosphate phosphatase activity • anion binding • molecular function regulator activity • heterocyclic compound binding • carbohydrate derivative binding • hydrolase activity, acting on acid anhydrides • catalytic activity • ribonucleotide binding • pyrophosphatase activity • GTPase activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • purine ribonucleoside triphosphate binding • guanyl-nucleotide exchange factor activity • nucleoside phosphate binding • purine nucleotide binding • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • cation binding • transition metal ion binding • zinc ion binding • metal ion binding • identical protein binding • multicellular organismal process • rod bipolar cell differentiation • cellular developmental process • sensory organ development • retina development in camera-type eye • visual system development • neural retina development • neurogenesis • multicellular organism development • eye morphogenesis • neuron differentiation • cell differentiation • anatomical structure development • animal organ morphogenesis
Gene Ontology	Biological Process	• multicellular organismal process • rod bipolar cell differentiation • cellular developmental process • sensory organ development • retina development in camera-type eye • visual system development • neural retina development • neurogenesis • multicellular organism development • eye morphogenesis • neuron differentiation • cell differentiation • anatomical structure development • animal organ morphogenesis • sensory system development • system development • developmental process • camera-type eye morphogenesis • eye development • animal organ development • nervous system development • retinal bipolar neuron differentiation • glutamatergic neuron differentiation • generation of neurons • retina morphogenesis in camera-type eye • anatomical structure morphogenesis • sensory organ morphogenesis • camera-type eye development • cellular process • cellular response to stimulus • response to light stimulus • response to stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of cellular process • signaling • detection of abiotic stimulus • cell communication • signal transduction • detection of light stimulus • phototransduction • detection of external stimulus • regulation of biological process • biological regulation • detection of visible light • response to external stimulus • detection of stimulus • G protein-coupled receptor signaling pathway • G protein-coupled opsin signaling pathway • phototransduction, visible light • response to light intensity • podosome assembly • organelle assembly • protein-containing complex organization • membraneless organelle assembly • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • protein-containing complex assembly • cellular component organization or biogenesis • biosynthetic process • metabolic process • macromolecule metabolic process • gene expression • macromolecule biosynthetic process • multicellular organismal-level homeostasis • homeostatic process • anatomical structure homeostasis • tissue homeostasis • retina homeostasis • photoreceptor cell maintenance • absorption of visible light • light absorption • microtubule cytoskeleton organization • microtubule-based process • cytoskeleton organization • sensory perception of light stimulus • system process • sensory perception • nervous system process • visual perception • thermoception • sensory perception of temperature stimulus • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of temperature stimulus involved in thermoception • detection of temperature stimulus • detection of stimulus involved in sensory perception • taxis • thermotaxis • locomotion • cellular anatomical structure • membrane • cell-cell junction • anchoring junction • cell junction • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • cell-cell junction • anchoring junction • cell junction • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • cell periphery • protein-containing complex • plasma membrane protein complex • plasma membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • membrane protein complex • receptor complex • sperm midpiece • 9+2 motile cilium • sperm flagellum • motile cilium • photoreceptor inner segment membrane • plasma membrane region • photoreceptor inner segment • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • cell projection membrane • Golgi membrane • intracellular anatomical structure • Golgi apparatus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasm • outer membrane • sperm head • sperm head plasma membrane • sperm plasma membrane • rod photoreceptor outer segment
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1 H:H:?2 H:H:?4 H:H:?5
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	MAN
PDB Residues	H:H:?3
Environment Details	Open EMBL-EBI Page
Code	MAN
Name	alpha-D-mannopyranose
Synonyms	alpha-D-mannose; D-mannose; mannose
Identifier
Formula	C6 H12 O6
Molecular Weight	180.156
SMILES
PubChem	185698
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	5
Total Bonds	24
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P02699
Sequence	>2I37_Chain_R M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H K K L R T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G Y F V F G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K P M S N F R F G E N H A I M G V A F T W V M A L A C A A P P L V G W S R Y I P E G M Q C S C G I D Y Y T P H E E T N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T E S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H Q G S D F G P I F M T I P A F F A K T S A V Y N P V I Y I M M N R N C M V T T L C C G K N P L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8P15	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.9	2024-11-20	To be published
	8P15 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.9	2024-11-20	To be published
	8P13	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.2	2024-11-20	To be published
	8P13 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.2	2024-11-20	To be published
	8P12	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	3.21	2024-11-20	To be published
	8P12 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.21	2024-11-20	To be published
	9EPR	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-	Gi1/β1/γ2	4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-		4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPQ	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.15	2024-10-23	10.1038/s41467-024-53208-2
	9EPQ (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.15	2024-10-23	10.1038/s41467-024-53208-2
	9EPP	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.06	2024-10-23	10.1038/s41467-024-53208-2
	9EPP (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.06	2024-10-23	10.1038/s41467-024-53208-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	10.1038/s41467-023-40911-9
	8FD1 (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		4.25	2023-08-30	10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	10.1038/s41467-023-40911-9
	8FD0 (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.71	2023-08-30	10.1038/s41467-023-40911-9
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	10.1038/s41467-023-40911-9
	8FCZ (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-		3.7	2023-08-30	10.1038/s41467-023-40911-9
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4	2021-07-07	10.1038/s41586-021-03721-x
	7MTB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4	2021-07-07	10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4.1	2021-07-07	10.1038/s41586-021-03721-x
	7MTA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.1	2021-07-07	10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	7	2021-07-07	10.1038/s41586-021-03721-x
	7MT9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		7	2021-07-07	10.1038/s41586-021-03721-x
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	5.8	2021-07-07	10.1038/s41586-021-03721-x
	7MT8 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		5.8	2021-07-07	10.1038/s41586-021-03721-x
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol		2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol		2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PEL (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol		3.19	2020-06-24	To be published
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6NWE (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		2.71	2020-02-12	To be published
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	10.1074/jbc.RA119.010089
	6OFJ (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		4.5	2019-08-21	10.1074/jbc.RA119.010089
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.3	2019-07-24	10.1016/j.molcel.2019.06.007
	6OYA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2019-07-24	10.1016/j.molcel.2019.06.007
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.9	2019-07-24	10.1016/j.molcel.2019.06.007
	6OY9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.9	2019-07-24	10.1016/j.molcel.2019.06.007
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gi1/β1/γ1	4.38	2019-07-10	10.7554/eLife.46041
	6QNO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.38	2019-07-10	10.7554/eLife.46041
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	10.1073/pnas.1902192116
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Go	3.12	2018-10-03	10.1126/sciadv.aat7052
	6FUF (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.12	2018-10-03	10.1126/sciadv.aat7052
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/β1/γ2	4.5	2018-06-20	10.1038/s41586-018-0215-y
	6CMO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-		4.5	2018-06-20	10.1038/s41586-018-0215-y
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	10.1073/pnas.1718084115
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	10.1073/pnas.1718084115
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	10.1038/nprot.2017.135
	5WKT (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		3.2	2017-12-13	10.1038/nprot.2017.135
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	10.1016/j.cell.2017.07.002
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	10.1073/pnas.1617446114
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	-	2.7	2017-03-15	10.1073/pnas.1617446114
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.3	2016-08-10	10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	10.15252/embr.201642671
	5EN0 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.81	2016-08-10	10.15252/embr.201642671
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	10.1038/sdata.2016.21
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	10.1016/j.str.2015.09.015
	4X1H (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-		2.29	2015-11-04	10.1016/j.str.2015.09.015
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	10.1038/nature14656
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2015-06-17	10.1371/journal.pone.0126970
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Arrestin1 Finger Loop	2.75	2014-09-17	10.1038/ncomms5801
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	10.1002/anie.201302374
	4J4Q (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-		2.65	2013-10-30	10.1002/anie.201302374
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	10.1038/embor.2013.44
	4BEY (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2013-05-08	10.1038/embor.2013.44
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	10.1038/embor.2013.44
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	10.1073/pnas.1114089108
	4A4M (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2012-01-25	10.1073/pnas.1114089108
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	10.1016/j.jmb.2011.08.044
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2011-08-17	10.1016/j.jmb.2011.08.044
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	10.1038/nature09795
	2X72 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3	2011-03-16	10.1038/nature09795
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	3	2011-03-09	10.1038/nature09789
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	10.1038/nature09789
	3PQR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.85	2011-03-09	10.1038/nature09789
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	10.1016/j.bpj.2010.08.003
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	10.1038/nature07330
	3DQB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.2	2008-09-23	10.1038/nature07330
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	10.1107/S0907444908017162
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	10.1107/S0907444908017162
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	10.1038/nature07063
	3CAP (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2008-06-24	10.1038/nature07063
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	10.1038/nature06925
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	10.1074/jbc.C800040200
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	10.1529/biophysj.107.108225
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	10.1016/j.jmb.2007.03.007
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	10.1073/pnas.0608022103
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	10.1073/pnas.0608022103
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.6	2006-09-02	10.1002/anie.200600595
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.8	2006-08-22	10.1073/pnas.0601765103
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	10.1016/j.jmb.2004.07.044
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	10.1016/j.jmb.2004.08.090
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	10.1073/pnas.082666399
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	10.1021/bi0155091
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	10.1126/science.289.5480.739

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