psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C2	R:R:C282	7.28	No	No	0	6	2
2	R:R:N15	R:R:T4	8.77	No	No	1	7	6
3	R:R:T4	R:R:V20	12.69	No	Yes	1	6	6
4	R:R:G6	R:R:P7	4.06	No	No	1	6	6
5	R:R:F9	R:R:G6	9.03	Yes	No	1	7	6
6	R:R:G6	R:R:Y10	2.9	No	Yes	1	6	7
7	R:R:N8	R:R:P7	4.89	Yes	No	1	4	6
8	R:R:F9	R:R:P7	2.89	Yes	No	1	7	6
9	R:R:F9	R:R:N8	7.25	Yes	Yes	1	7	4
10	R:R:F24	R:R:N8	6.04	Yes	Yes	1	5	4
11	R:R:N8	R:R:P107	4.89	Yes	No	1	4	3
12	R:R:F9	R:R:P23	13	Yes	Yes	1	7	5
13	R:R:I179	R:R:Y10	3.63	Yes	Yes	1	1	7
14	R:R:D190	R:R:Y10	5.75	Yes	Yes	1	4	7
15	R:R:Y10	R:R:Y192	2.98	Yes	Yes	1	7	5
16	R:R:T193	R:R:Y10	19.97	Yes	Yes	1	5	7
17	R:R:P12	R:R:V11	3.53	Yes	Yes	1	8	8
18	R:R:V11	R:R:V20	3.21	Yes	Yes	1	8	6
19	R:R:P23	R:R:V11	3.53	Yes	Yes	1	5	8
20	R:R:Q184	R:R:V11	14.33	Yes	Yes	1	3	8
21	R:R:P12	R:R:Q184	4.74	Yes	Yes	1	8	3
22	R:R:P12	R:R:Y192	5.56	Yes	Yes	1	8	5
23	R:R:M288	R:R:P12	6.71	No	Yes	0	4	8
24	R:R:F13	R:R:L31	4.87	No	No	0	4	4
25	R:R:K16	R:R:S14	13.77	No	No	0	7	4
26	R:R:G18	R:R:N15	3.39	No	No	0	3	7
27	R:R:N15	R:R:V20	7.39	No	Yes	1	7	6
28	R:R:T17	R:R:V19	4.76	No	No	0	6	3
29	R:R:V19	R:R:Y30	8.83	No	Yes	0	3	4
30	R:R:V20	R:R:Y30	7.57	Yes	Yes	1	6	4
31	R:R:A26	R:R:R21	2.77	No	No	0	2	4
32	R:R:Q28	R:R:R21	4.67	No	No	1	5	4
33	R:R:R21	R:R:Y30	16.46	No	Yes	1	4	4
34	R:R:P23	R:R:S22	5.34	Yes	No	0	5	5
35	R:R:F24	R:R:S22	3.96	Yes	No	0	5	5
36	R:R:E25	R:R:S22	4.31	No	No	0	7	5
37	R:R:P180	R:R:P23	5.84	Yes	Yes	1	3	5
38	R:R:P23	R:R:Q184	6.32	Yes	Yes	1	5	3
39	R:R:F103	R:R:F24	8.57	Yes	Yes	1	8	5
40	R:R:F24	R:R:G106	3.01	Yes	No	1	5	8
41	R:R:F24	R:R:P107	13	Yes	No	1	5	3
42	R:R:C110	R:R:F24	2.79	Yes	Yes	1	9	5
43	R:R:P27	R:R:Y29	9.74	No	No	0	8	4
44	R:R:P27	R:R:Y102	9.74	No	No	0	8	4
45	R:R:Q28	R:R:Y30	15.78	No	Yes	1	5	4
46	R:R:F37	R:R:Y29	4.13	No	No	0	5	4
47	R:R:G101	R:R:Y29	2.9	No	No	0	4	4
48	R:R:L31	R:R:M183	7.07	No	Yes	0	4	2
49	R:R:A32	R:R:Q36	4.55	No	No	0	3	2
50	R:R:A32	R:R:F37	4.16	No	No	0	3	5
51	R:R:E33	R:R:P34	7.86	No	No	0	3	3
52	R:R:E33	R:R:W35	6.54	No	No	8	3	3
53	R:R:E33	R:R:Q36	7.65	No	No	8	3	2
54	R:R:Q36	R:R:W35	21.9	No	No	8	2	3
55	R:R:F37	R:R:M183	4.98	No	Yes	0	5	2
56	R:R:L40	R:R:M39	2.83	No	No	0	5	4
57	R:R:L40	R:R:M183	2.83	No	Yes	7	5	2
58	R:R:F293	R:R:L40	7.31	No	No	7	5	5
59	R:R:A41	R:R:S98	3.42	No	No	0	5	5
60	R:R:L47	R:R:Y43	12.89	No	No	5	7	4
61	R:R:T297	R:R:Y43	4.99	No	No	5	6	4
62	R:R:I48	R:R:M44	5.83	No	No	0	6	7
63	R:R:M44	R:R:T94	6.02	No	No	0	7	7
64	R:R:L95	R:R:M44	4.24	No	No	0	6	7
65	R:R:F45	R:R:M49	7.46	No	No	0	3	5
66	R:R:L47	R:R:T297	7.37	No	No	5	7	6
67	R:R:L47	R:R:V300	8.94	No	No	5	7	7
68	R:R:F91	R:R:I48	5.02	No	No	0	7	6
69	R:R:F52	R:R:P53	4.33	Yes	No	0	6	4
70	R:R:F52	R:R:F56	6.43	Yes	No	0	6	4
71	R:R:F52	R:R:V87	5.24	Yes	Yes	9	6	6
72	R:R:F52	R:R:F88	6.43	Yes	No	9	6	4
73	R:R:I54	R:R:N55	2.83	Yes	Yes	3	8	9
74	R:R:I54	R:R:T58	3.04	Yes	Yes	3	8	9
75	R:R:I54	R:R:P303	3.39	Yes	No	3	8	9
76	R:R:I307	R:R:I54	5.89	Yes	Yes	3	7	8
77	R:R:I54	R:R:M308	5.83	Yes	Yes	3	8	6
78	R:R:D83	R:R:N55	13.46	No	Yes	3	9	9
79	R:R:L84	R:R:N55	2.75	No	Yes	0	7	9
80	R:R:N55	R:R:P303	6.52	Yes	No	3	9	9
81	R:R:L57	R:R:V61	2.98	No	Yes	0	6	7
82	R:R:A80	R:R:T58	3.36	No	Yes	0	9	9
83	R:R:I307	R:R:T58	3.04	Yes	Yes	3	7	9
84	R:R:A80	R:R:L59	3.15	No	No	0	9	7
85	R:R:Q64	R:R:Y60	12.4	No	No	0	5	3
86	R:R:H65	R:R:V61	2.77	No	Yes	0	5	7
87	R:R:L68	R:R:T62	2.95	No	Yes	0	7	7
88	R:R:R69	R:R:T62	5.17	No	Yes	0	6	7
89	R:R:L77	R:R:T62	5.9	No	Yes	0	5	7
90	R:R:R69	R:R:V63	3.92	No	No	0	6	2
91	R:R:H65	R:R:Q64	3.71	No	No	0	5	5
92	R:R:K66	R:R:R69	14.85	No	No	0	6	6
93	R:R:P71	R:R:T70	3.5	No	No	0	6	7
94	R:R:N73	R:R:T70	7.31	No	No	0	8	7
95	R:R:E150	R:R:P71	9.43	No	No	0	2	6
96	R:R:L76	R:R:N73	4.12	No	No	0	8	8
97	R:R:I75	R:R:L76	2.85	Yes	No	0	7	8
98	R:R:I75	R:R:N78	2.83	Yes	Yes	4	7	9
99	R:R:I75	R:R:S127	6.19	Yes	No	4	7	8
100	R:R:I75	R:R:V130	7.68	Yes	No	0	7	7
101	R:R:I75	R:R:L131	2.85	Yes	No	0	7	9
102	R:R:I123	R:R:N78	5.66	Yes	Yes	4	7	9
103	R:R:N78	R:R:S127	4.47	Yes	No	4	9	8
104	R:R:N78	R:R:V157	2.96	Yes	No	4	9	7
105	R:R:N78	R:R:T160	5.85	Yes	No	4	9	7
106	R:R:N78	R:R:W161	10.17	Yes	No	4	9	9
107	R:R:D83	R:R:L79	6.79	No	No	0	9	9
108	R:R:L79	R:R:S127	3	No	No	0	9	8
109	R:R:F85	R:R:V81	3.93	No	No	0	6	6
110	R:R:A82	R:R:I123	4.87	No	Yes	0	8	7
111	R:R:D83	R:R:P303	6.44	No	No	3	9	9
112	R:R:L84	R:R:V87	2.98	No	Yes	0	7	6
113	R:R:F116	R:R:F85	7.5	No	No	0	4	6
114	R:R:F91	R:R:M86	11.2	No	No	0	7	7
115	R:R:K296	R:R:M86	4.32	No	No	0	7	7
116	R:R:A299	R:R:M86	6.44	No	No	0	9	7
117	R:R:F88	R:R:V87	3.93	No	Yes	9	4	6
118	R:R:F91	R:R:V87	7.87	No	Yes	0	7	6
119	R:R:F88	R:R:T92	5.19	No	No	0	4	8
120	R:R:E113	R:R:G89	3.27	No	No	0	5	4
121	R:R:T92	R:R:T93	3.14	No	Yes	0	8	5
122	R:R:F103	R:R:T93	3.89	Yes	Yes	1	8	5
123	R:R:F105	R:R:T93	5.19	Yes	Yes	1	7	5
124	R:R:E113	R:R:T93	16.93	No	Yes	0	5	5
125	R:R:C185	R:R:T94	6.76	No	No	0	5	7
126	R:R:L95	R:R:L99	5.54	No	No	0	6	4
127	R:R:F103	R:R:T97	6.49	Yes	No	0	8	5
128	R:R:H100	R:R:Y102	7.62	No	No	0	4	4
129	R:R:H100	R:R:V104	4.15	No	No	0	4	4
130	R:R:G101	R:R:Y102	4.35	No	No	0	4	4
131	R:R:F103	R:R:F105	4.29	Yes	Yes	1	8	7
132	R:R:F103	R:R:G109	3.01	Yes	No	0	8	5
133	R:R:C110	R:R:F103	4.19	Yes	Yes	1	9	8
134	R:R:F105	R:R:V104	5.24	Yes	No	0	7	4
135	R:R:G106	R:R:P107	4.06	No	No	1	8	3
136	R:R:G109	R:R:L112	3.42	No	No	0	5	4
137	R:R:C110	R:R:P180	3.77	Yes	Yes	1	9	3
138	R:R:C110	R:R:C187	7.28	Yes	No	1	9	9
139	R:R:L172	R:R:N111	4.12	No	No	2	5	7
140	R:R:N111	R:R:Y178	3.49	No	Yes	2	7	3
141	R:R:G114	R:R:Y178	8.69	No	Yes	0	5	3
142	R:R:F115	R:R:F116	9.65	Yes	No	0	6	4
143	R:R:A168	R:R:F115	2.77	No	Yes	0	7	6
144	R:R:F115	R:R:L172	7.31	Yes	No	2	6	5
145	R:R:F115	R:R:Y178	4.13	Yes	Yes	2	6	3
146	R:R:A168	R:R:T118	3.36	No	No	0	7	4
147	R:R:T118	R:R:Y178	9.99	No	Yes	0	4	3
148	R:R:I123	R:R:L119	7.14	Yes	No	0	7	5
149	R:R:L119	R:R:L165	2.77	No	No	0	5	3
150	R:R:A168	R:R:L119	3.15	No	No	0	7	5
151	R:R:E122	R:R:W126	8.72	Yes	Yes	2	6	5
152	R:R:A164	R:R:E122	3.02	No	Yes	0	8	6
153	R:R:C167	R:R:E122	7.6	No	Yes	2	5	6
154	R:R:E122	R:R:H211	18.46	Yes	Yes	2	6	6
155	R:R:I123	R:R:W161	7.05	Yes	No	4	7	9
156	R:R:L125	R:R:W126	6.83	No	Yes	0	7	5
157	R:R:L125	R:R:W265	6.83	No	No	0	7	8
158	R:R:V129	R:R:W126	9.81	No	Yes	0	7	5
159	R:R:F159	R:R:W126	3.01	Yes	Yes	2	3	5
160	R:R:M163	R:R:W126	4.65	Yes	Yes	2	4	5
161	R:R:H211	R:R:W126	12.7	Yes	Yes	2	6	5
162	R:R:F261	R:R:L128	7.31	No	No	0	9	8
163	R:R:L128	R:R:Y306	8.21	No	No	0	8	9
164	R:R:I133	R:R:V129	3.07	No	No	0	6	7
165	R:R:E134	R:R:L131	3.98	No	No	0	8	9
166	R:R:E134	R:R:F148	8.16	No	No	0	8	7
167	R:R:R135	R:R:Y257	8.23	No	Yes	0	9	8
168	R:R:C140	R:R:Y136	5.38	No	Yes	0	7	7
169	R:R:P142	R:R:Y136	19.47	No	Yes	0	8	7
170	R:R:F221	R:R:Y136	6.19	No	Yes	0	4	7
171	R:R:C222	R:R:Y136	12.1	No	Yes	0	8	7
172	R:R:P142	R:R:V137	3.53	No	No	0	8	4
173	R:R:L226	R:R:V139	4.47	No	No	0	8	8
174	R:R:C140	R:R:L226	4.76	No	No	0	7	8
175	R:R:F146	R:R:M143	6.22	No	No	0	5	6
176	R:R:F146	R:R:H152	10.18	No	No	0	5	5
177	R:R:H152	R:R:N151	19.13	No	No	0	5	4
178	R:R:T160	R:R:V157	3.17	No	No	4	7	7
179	R:R:F159	R:R:V162	5.24	Yes	No	0	3	4
180	R:R:F159	R:R:M163	3.73	Yes	Yes	2	3	4
181	R:R:T160	R:R:W161	3.64	No	No	4	7	9
182	R:R:M163	R:R:Y206	3.59	Yes	No	0	4	4
183	R:R:H211	R:R:M163	10.51	Yes	Yes	2	6	4
184	R:R:C167	R:R:M207	3.24	No	No	2	5	5
185	R:R:C167	R:R:H211	4.42	No	Yes	2	5	6
186	R:R:P170	R:R:P171	5.84	Yes	Yes	2	7	5
187	R:R:P170	R:R:W175	4.05	Yes	Yes	2	7	5
188	R:R:F203	R:R:P170	2.89	Yes	Yes	2	6	7
189	R:R:P171	R:R:S176	7.13	Yes	No	2	5	5
190	R:R:P171	R:R:Y178	9.74	Yes	Yes	2	5	3
191	R:R:F203	R:R:P171	5.78	Yes	Yes	2	6	5
192	R:R:L172	R:R:Y178	3.52	No	Yes	2	5	3
193	R:R:N199	R:R:W175	5.65	No	Yes	2	3	5
194	R:R:S202	R:R:W175	8.65	No	Yes	2	4	5
195	R:R:F203	R:R:W175	22.05	Yes	Yes	2	6	5
196	R:R:W175	R:R:Y206	10.61	Yes	No	0	5	4
197	R:R:F203	R:R:S176	18.5	Yes	No	2	6	5
198	R:R:I179	R:R:R177	7.52	Yes	No	1	1	5
199	R:R:D190	R:R:R177	4.76	Yes	No	1	4	5
200	R:R:D190	R:R:I179	8.4	Yes	Yes	1	4	1
201	R:R:I179	R:R:Y192	6.04	Yes	Yes	1	1	5
202	R:R:P180	R:R:Q184	6.32	Yes	Yes	1	3	3
203	R:R:C187	R:R:P180	5.65	No	Yes	1	9	3
204	R:R:E181	R:R:G182	3.27	Yes	No	0	4	3
205	R:R:E181	R:R:S186	8.62	Yes	No	0	4	5
206	R:R:A292	R:R:E181	4.53	No	Yes	0	5	4
207	R:R:F293	R:R:M183	4.98	No	Yes	7	5	2
208	R:R:C185	R:R:S186	3.44	No	No	0	5	5
209	R:R:I189	R:R:Y191	3.63	No	No	0	4	6
210	R:R:D190	R:R:Y192	6.9	Yes	Yes	1	4	5
211	R:R:D190	R:R:T193	5.78	Yes	Yes	1	4	5
212	R:R:D190	R:R:N200	4.04	Yes	No	1	4	4
213	R:R:Y191	R:R:Y192	10.92	No	Yes	0	6	5
214	R:R:Y191	R:R:Y268	5.96	No	No	0	6	6
215	R:R:T193	R:R:Y192	3.75	Yes	Yes	1	5	5
216	R:R:P194	R:R:T193	5.25	No	Yes	0	1	5
217	R:R:E197	R:R:H195	16	No	No	0	3	4
218	R:R:H195	R:R:T198	10.95	No	No	1	4	1
219	R:R:H195	R:R:N200	3.83	No	No	1	4	4
220	R:R:E196	R:R:E197	7.61	No	No	0	1	3
221	R:R:N200	R:R:T198	5.85	No	No	1	4	1
222	R:R:N199	R:R:S202	4.47	No	No	2	3	4
223	R:R:F203	R:R:M207	7.46	Yes	No	2	6	5
224	R:R:V210	R:R:Y206	3.79	No	No	0	4	4
225	R:R:H211	R:R:M207	6.57	Yes	No	2	6	5
226	R:R:F208	R:R:F212	7.5	Yes	No	0	5	8
227	R:R:F208	R:R:F273	12.86	Yes	No	6	5	6
228	R:R:F208	R:R:F276	3.22	Yes	No	6	5	4
229	R:R:I213	R:R:V209	6.14	No	No	0	4	5
230	R:R:H211	R:R:V210	17.99	Yes	No	0	6	4
231	R:R:F212	R:R:L216	9.74	No	No	0	8	7
232	R:R:A269	R:R:F212	4.16	No	No	0	7	8
233	R:R:I214	R:R:P215	3.39	No	No	0	5	9
234	R:R:I219	R:R:Y223	3.63	No	Yes	0	8	9
235	R:R:F261	R:R:I219	7.54	No	No	0	9	8
236	R:R:F221	R:R:Q225	12.88	No	No	0	4	4
237	R:R:C222	R:R:Y223	5.38	No	Yes	0	8	9
238	R:R:V254	R:R:Y223	6.31	No	Yes	0	8	9
239	R:R:Y223	R:R:Y257	10.92	Yes	Yes	0	9	8
240	R:R:V258	R:R:Y223	5.05	No	Yes	0	8	9
241	R:R:K231	R:R:V227	4.55	No	No	0	5	5
242	R:R:V227	R:R:V254	3.21	No	No	0	5	8
243	R:R:E247	R:R:V230	2.85	Yes	No	0	7	8
244	R:R:V230	R:R:V250	6.41	No	No	0	8	8
245	R:R:A234	R:R:Q244	4.55	No	No	0	5	4
246	R:R:A234	R:R:E247	6.03	No	Yes	0	5	7
247	R:R:Q236	R:R:Q237	5.12	No	No	0	2	5
248	R:R:Q237	R:R:S240	10.11	No	No	0	5	4
249	R:R:E239	R:R:Q238	11.47	No	No	0	2	5
250	R:R:S240	R:R:T243	7.99	No	No	0	4	5
251	R:R:E247	R:R:T251	4.23	Yes	No	0	7	6
252	R:R:E249	R:R:R252	15.12	No	No	0	7	7
253	R:R:I255	R:R:T251	3.04	No	No	0	5	6
254	R:R:M253	R:R:Y257	4.79	No	Yes	0	8	8
255	R:R:I256	R:R:I305	2.94	No	No	0	5	8
256	R:R:Y257	R:R:Y306	8.94	Yes	No	0	8	9
257	R:R:A260	R:R:I305	6.5	No	No	0	7	8
258	R:R:F261	R:R:W265	8.02	No	No	0	9	8
259	R:R:L262	R:R:L266	9.69	No	No	0	6	6
260	R:R:C264	R:R:W265	6.53	Yes	No	0	8	8
261	R:R:C264	R:R:S298	6.89	Yes	No	10	8	9
262	R:R:C264	R:R:N302	7.87	Yes	No	10	8	9
263	R:R:P291	R:R:Y268	2.78	No	No	0	6	6
264	R:R:A295	R:R:Y268	5.34	No	No	0	8	6
265	R:R:I275	R:R:V271	3.07	No	No	0	4	5
266	R:R:P291	R:R:V271	8.84	No	No	0	6	5
267	R:R:F273	R:R:F276	5.36	No	No	6	6	4
268	R:R:F273	R:R:T277	3.89	No	No	6	6	5
269	R:R:H278	R:R:Y274	35.93	No	No	0	3	4
270	R:R:S281	R:R:Y274	3.82	No	No	11	4	4
271	R:R:F283	R:R:Y274	6.19	Yes	No	11	4	4
272	R:R:F276	R:R:T277	6.49	No	No	6	4	5
273	R:R:H278	R:R:T277	6.85	No	No	0	3	5
274	R:R:G280	R:R:S281	3.71	No	No	0	1	4
275	R:R:F283	R:R:S281	5.28	Yes	No	11	4	4
276	R:R:F283	R:R:F287	11.79	Yes	No	0	4	4
277	R:R:G284	R:R:P285	4.06	No	No	0	4	3
278	R:R:F287	R:R:I286	8.79	No	No	0	4	1
279	R:R:F293	R:R:T289	5.19	No	No	0	5	4
280	R:R:I290	R:R:P291	6.77	No	No	0	5	6
281	R:R:F294	R:R:I290	3.77	No	No	0	7	5
282	R:R:T297	R:R:V300	4.76	No	No	5	6	7
283	R:R:N302	R:R:S298	2.98	No	No	10	9	9
284	R:R:V300	R:R:Y301	5.05	No	No	0	7	5
285	R:R:M308	R:R:V304	4.56	Yes	No	0	6	7
286	R:R:I305	R:R:Y306	6.04	No	No	0	8	9
287	R:R:I307	R:R:M308	4.37	Yes	Yes	3	7	6
288	R:R:F313	R:R:I307	10.05	No	Yes	0	8	7
289	R:R:M308	R:R:M317	2.89	Yes	No	0	6	6
290	R:R:N310	R:R:Q312	3.96	No	No	0	8	6
291	R:R:F313	R:R:N310	8.46	No	No	0	8	8
292	R:R:K311	R:R:R314	3.71	No	No	0	4	8
293	R:R:K311	R:R:N315	2.8	No	No	0	4	5
294	R:R:K311	R:R:Q312	2.71	No	No	0	4	6
295	R:R:A132	R:R:Y223	2.67	No	Yes	0	9	9
296	R:R:F283	R:R:M288	2.49	Yes	No	0	4	4
297	R:R:F148	R:R:L72	2.44	No	No	0	7	8
298	R:R:F148	R:R:H152	2.26	No	No	0	7	5
299	R:R:E5	R:R:Y10	2.24	No	Yes	0	6	7
300	R:R:E150	R:R:Y74	2.24	No	No	0	2	5
301	R:R:G89	R:R:G90	2.11	No	No	0	4	6
302	R:R:G120	R:R:G121	2.11	No	No	0	8	7
303	R:R:F105	R:R:Y96	2.06	Yes	No	0	7	4
304	R:R:G51	R:R:P53	2.03	No	No	0	8	4
305	R:R:C2	R:R:G3	1.96	No	No	0	6	6
306	R:R:A82	R:R:G120	1.95	No	No	0	8	8
307	R:R:A124	R:R:G121	1.95	No	No	0	9	7
308	R:R:A269	R:R:G270	1.95	No	No	0	7	5
309	R:R:A153	R:R:P71	1.87	No	No	0	7	6
310	R:R:A169	R:R:P170	1.87	No	Yes	0	3	7
311	R:R:G109	R:R:T108	1.82	No	No	0	5	1
312	R:R:P215	R:R:V129	1.77	No	No	0	9	7
313	R:R:G284	R:R:M288	1.75	No	No	0	4	4
314	R:R:G51	R:R:L50	1.71	No	No	0	8	5
315	R:R:C316	R:R:V61	1.71	No	Yes	0	5	7
316	R:R:G149	R:R:N151	1.7	No	No	0	6	4
317	R:R:E181	R:R:G188	1.64	Yes	No	0	4	5
318	R:R:C264	R:R:I263	1.64	Yes	No	0	8	5
319	R:R:L266	R:R:P267	1.64	No	No	0	6	9
320	R:R:C2	R:R:M1	1.62	No	No	0	6	6
321	R:R:A117	R:R:K296	1.61	No	No	0	5	7
322	R:R:A166	R:R:M163	1.61	No	Yes	0	4	4
323	R:R:S98	R:R:T94	1.6	No	No	0	5	7
324	R:R:V137	R:R:V138	1.6	No	No	0	4	8
325	R:R:V138	R:R:V139	1.6	No	No	0	8	8
326	R:R:S240	R:R:T242	1.6	No	No	0	4	4
327	R:R:V250	R:R:V254	1.6	No	No	0	8	8
328	R:R:A269	R:R:L266	1.58	No	No	0	7	6
329	R:R:T58	R:R:T62	1.57	Yes	Yes	0	9	7
330	R:R:I133	R:R:V218	1.54	No	No	0	6	6
331	R:R:I154	R:R:V157	1.54	No	No	0	3	7
332	R:R:F159	R:R:G156	1.51	Yes	No	0	3	6
333	R:R:K16	R:R:T17	1.5	No	No	0	7	6
334	R:R:L68	R:R:V61	1.49	No	Yes	0	7	7
335	R:R:I213	R:R:I214	1.47	No	No	0	4	5
336	R:R:I214	R:R:I217	1.47	No	No	0	5	4
337	R:R:I255	R:R:I259	1.47	No	No	0	5	5
338	R:R:I256	R:R:I259	1.47	No	No	0	5	5
339	R:R:I48	R:R:M49	1.46	No	No	0	6	5
340	R:R:K16	R:R:M1	1.44	No	No	0	7	6
341	R:R:A272	R:R:F208	1.39	No	Yes	0	5	5
342	R:R:L46	R:R:L50	1.38	No	No	0	5	5
343	R:R:I275	R:R:Q279	1.37	No	No	0	4	1
344	R:R:E247	R:R:K248	1.35	Yes	No	0	7	4
345	R:R:E201	R:R:Q279	1.27	No	No	0	3	1
346	R:R:E239	R:R:Q237	1.27	No	No	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N8	5.7675	4	1	4
2	R:R:F9	8.0425	4	1	7
3	R:R:Y10	6.245	6	1	7
4	R:R:V11	6.15	4	1	8
5	R:R:P12	5.135	4	1	8
6	R:R:V20	7.715	4	1	6
7	R:R:P23	6.806	5	1	5
8	R:R:F24	6.22833	6	1	5
9	R:R:Y30	12.16	4	1	4
10	R:R:F52	5.6075	4	9	6
11	R:R:I54	4.196	5	3	8
12	R:R:N55	6.39	4	3	9
13	R:R:T58	2.7525	4	3	9
14	R:R:V61	2.2375	4	0	7
15	R:R:T62	3.8975	4	0	7
16	R:R:I75	4.48	5	4	7
17	R:R:N78	5.32333	6	4	9
18	R:R:V87	5.005	4	9	6
19	R:R:T93	7.2875	4	1	5
20	R:R:F103	5.07333	6	1	8
21	R:R:F105	4.195	4	1	7
22	R:R:C110	4.5075	4	1	9
23	R:R:F115	5.965	4	2	6
24	R:R:E122	9.45	4	2	6
25	R:R:I123	6.18	4	4	7
26	R:R:W126	7.62	6	2	5
27	R:R:Y136	10.785	4	0	7
28	R:R:F159	3.3725	4	2	3
29	R:R:M163	4.818	5	2	4
30	R:R:P170	3.6625	4	2	7
31	R:R:P171	7.1225	4	2	5
32	R:R:W175	10.202	5	2	5
33	R:R:Y178	6.59333	6	2	3
34	R:R:I179	6.3975	4	1	1
35	R:R:P180	5.395	4	1	3
36	R:R:E181	4.515	4	0	4
37	R:R:M183	4.965	4	7	2
38	R:R:Q184	7.9275	4	1	3
39	R:R:D190	5.93833	6	1	4
40	R:R:Y192	6.025	6	1	5
41	R:R:T193	8.6875	4	1	5
42	R:R:F203	11.336	5	2	6
43	R:R:F208	6.2425	4	6	5
44	R:R:H211	11.775	6	2	6
45	R:R:Y223	5.66	6	0	9
46	R:R:E247	3.615	4	0	7
47	R:R:Y257	8.22	4	0	8
48	R:R:C264	5.7325	4	10	8
49	R:R:F283	6.4375	4	11	4
50	R:R:I307	5.8375	4	3	7
51	R:R:M308	4.4125	4	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K16	R:R:T17	10.1399	1.5	No	No	0	7	6
2	R:R:T17	R:R:V19	11.8194	4.76	No	No	0	6	3
3	R:R:V19	R:R:Y30	13.4959	8.83	No	Yes	0	3	4
4	R:R:V20	R:R:Y30	20.171	7.57	Yes	Yes	1	6	4
5	R:R:V11	R:R:V20	26.7971	3.21	Yes	Yes	1	8	6
6	R:R:P23	R:R:V11	18.6524	3.53	Yes	Yes	1	5	8
7	R:R:P12	R:R:Y192	14.3418	5.56	Yes	Yes	1	8	5
8	R:R:P23	R:R:S22	10.2548	5.34	Yes	No	0	5	5
9	R:R:F24	R:R:S22	10.8647	3.96	Yes	No	0	5	5
10	R:R:M288	R:R:P12	19.4952	6.71	No	Yes	0	4	8
11	R:R:F103	R:R:F24	27.9648	8.57	Yes	Yes	1	8	5
12	R:R:F105	R:R:V104	22.911	5.24	Yes	No	0	7	4
13	R:R:H100	R:R:V104	22.2643	4.15	No	No	0	4	4
14	R:R:H100	R:R:Y102	21.6145	7.62	No	No	0	4	4
15	R:R:P27	R:R:Y102	10.4816	9.74	No	No	0	8	4
16	R:R:F37	R:R:Y29	18.2203	4.13	No	No	0	5	4
17	R:R:C110	R:R:P180	48.0224	3.77	Yes	Yes	1	9	3
18	R:R:C110	R:R:F103	48.7227	4.19	Yes	Yes	1	9	8
19	R:R:P180	R:R:Q184	38.3668	6.32	Yes	Yes	1	3	3
20	R:R:G101	R:R:Y102	10.4816	4.35	No	No	0	4	4
21	R:R:F91	R:R:I48	10.7743	5.02	No	No	0	7	6
22	R:R:F91	R:R:V87	14.2376	7.87	No	Yes	0	7	6
23	R:R:F88	R:R:V87	85.1296	3.93	No	Yes	9	4	6
24	R:R:F88	R:R:T92	86.76	5.19	No	No	0	4	8
25	R:R:T92	R:R:T93	86.6037	3.14	No	Yes	0	8	5
26	R:R:F103	R:R:T93	69.9327	3.89	Yes	Yes	1	8	5
27	R:R:L84	R:R:V87	89.8984	2.98	No	Yes	0	7	6
28	R:R:L84	R:R:N55	89.9658	2.75	No	Yes	0	7	9
29	R:R:I54	R:R:N55	18.2218	2.83	Yes	Yes	3	8	9
30	R:R:I54	R:R:T58	16.081	3.04	Yes	Yes	3	8	9
31	R:R:D83	R:R:N55	90.2708	13.46	No	Yes	3	9	9
32	R:R:T58	R:R:T62	13.0928	1.57	Yes	Yes	0	9	7
33	R:R:D83	R:R:L79	100	6.79	No	No	0	9	9
34	R:R:L79	R:R:S127	99.9356	3	No	No	0	9	8
35	R:R:N78	R:R:S127	92.2001	4.47	Yes	No	4	9	8
36	R:R:I123	R:R:N78	97.1681	5.66	Yes	Yes	4	7	9
37	R:R:I123	R:R:L119	97.0716	7.14	Yes	No	0	7	5
38	R:R:A168	R:R:L119	96.7528	3.15	No	No	0	7	5
39	R:R:A168	R:R:F115	49.5012	2.77	No	Yes	0	7	6
40	R:R:F115	R:R:Y178	47.2424	4.13	Yes	Yes	2	6	3
41	R:R:A168	R:R:T118	47.0984	3.36	No	No	0	7	4
42	R:R:T118	R:R:Y178	46.7705	9.99	No	Yes	0	4	3
43	R:R:P171	R:R:Y178	91.7204	9.74	Yes	Yes	2	5	3
44	R:R:F203	R:R:P171	78.3088	5.78	Yes	Yes	2	6	5
45	R:R:F203	R:R:M207	68.0923	7.46	Yes	No	2	6	5
46	R:R:H211	R:R:M207	64.2782	6.57	Yes	No	2	6	5
47	R:R:H211	R:R:W126	55.7565	12.7	Yes	Yes	2	6	5
48	R:R:L125	R:R:W126	45.5767	6.83	No	Yes	0	7	5
49	R:R:L125	R:R:W265	44.6282	6.83	No	No	0	7	8
50	R:R:P170	R:R:P171	11.6217	5.84	Yes	Yes	2	7	5
51	R:R:W175	R:R:Y206	14.0812	10.61	Yes	No	0	5	4
52	R:R:M163	R:R:Y206	10.2732	3.59	Yes	No	0	4	4
53	R:R:F261	R:R:W265	39.8394	8.02	No	No	0	9	8
54	R:R:F261	R:R:L128	11.3076	7.31	No	No	0	9	8
55	R:R:L128	R:R:Y306	10.2931	8.21	No	No	0	8	9
56	R:R:F261	R:R:I219	27.6522	7.54	No	No	0	9	8
57	R:R:I219	R:R:Y223	26.6653	3.63	No	Yes	0	8	9
58	R:R:C222	R:R:Y223	10.664	5.38	No	Yes	0	8	9
59	R:R:F283	R:R:M288	17.7345	2.49	Yes	No	0	4	4
60	R:R:F283	R:R:Y274	14.6682	6.19	Yes	No	11	4	4
61	R:R:H278	R:R:Y274	14.1579	35.93	No	No	0	3	4
62	R:R:H278	R:R:T277	13.5464	6.85	No	No	0	3	5
63	R:R:V254	R:R:Y223	10.5291	6.31	No	Yes	0	8	9
64	R:R:F24	R:R:N8	16.2098	6.04	Yes	Yes	1	5	4
65	R:R:G6	R:R:Y10	14.0904	2.9	No	Yes	1	6	7
66	R:R:P12	R:R:Q184	29.6428	4.74	Yes	Yes	1	8	3
67	R:R:F105	R:R:T93	16.0136	5.19	Yes	Yes	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8P12_nogp

PDB Summary
PDB	8P12_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	293
Number of Links	346
Number of Hubs	51
Number of Links mediated by Hubs	176
Number of Communities	11
Number of Nodes involved in Communities	87
Number of Links involved in Communities	125

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	100886
Length Of Smallest Path	3
Average Path Length	22.5617
Length of Longest Path	47
Minimum Path Strength	1.32
Average Path Strength	5.84471
Maximum Path Strength	21.39
Minimum Path Correlation	0.7
Average Path Correlation	0.940323
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	42.4175
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.9104
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • G-protein beta-subunit binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • localization • macromolecule localization • intracellular protein localization • multicellular organismal process • cellular developmental process • sensory organ development • photoreceptor cell differentiation • visual system development • cell development • eye morphogenesis • multicellular organism development • neurogenesis • neuron differentiation • cell differentiation • eye photoreceptor cell differentiation • anatomical structure development • animal organ morphogenesis • sensory system development • system development • photoreceptor cell development • developmental process • eye photoreceptor cell development • eye development • animal organ development • nervous system development • generation of neurons • anatomical structure morphogenesis • sensory organ morphogenesis • neuron development • phototransduction • detection of light stimulus • response to light stimulus • detection of external stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • protein-containing complex binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • retina development in camera-type eye • camera-type eye development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • opsin binding • arrestin family protein binding • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • vitamin binding • retinal binding • isoprenoid binding • retinoid binding • lipid binding • 11-cis retinal binding • small molecule binding • G-protein alpha-subunit binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • cation binding • transition metal ion binding • zinc ion binding • ion binding • metal ion binding • identical protein binding • rod bipolar cell differentiation • neural retina development • camera-type eye morphogenesis • retinal bipolar neuron differentiation • glutamatergic neuron differentiation • retina morphogenesis in camera-type eye • cellular response to light stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • detection of visible light • G protein-coupled opsin signaling pathway • phototransduction, visible light • response to light intensity • podosome assembly • organelle assembly • protein-containing complex organization • membraneless organelle assembly • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • protein-containing complex assembly • cellular component organization or biogenesis • biosynthetic process • metabolic process • macromolecule metabolic process • gene expression • macromolecule biosynthetic process • multicellular organismal-level homeostasis • homeostatic process • anatomical structure homeostasis • tissue homeostasis • retina homeostasis • photoreceptor cell maintenance • absorption of visible light • light absorption • microtubule cytoskeleton organization • microtubule-based process • cytoskeleton organization • sensory perception of light stimulus • visual perception • thermoception • sensory perception of temperature stimulus • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of temperature stimulus involved in thermoception • detection of temperature stimulus • detection of stimulus involved in sensory perception • taxis • thermotaxis • locomotion • cell-cell junction • anchoring junction • plasma membrane signaling receptor complex • G protein-coupled receptor complex • receptor complex • sperm midpiece • 9+2 motile cilium • sperm flagellum • motile cilium • photoreceptor inner segment membrane • plasma membrane region • photoreceptor inner segment • ciliary membrane • photoreceptor outer segment membrane • cell projection membrane • Golgi membrane • outer membrane • sperm head • sperm head plasma membrane • sperm plasma membrane • rod photoreceptor outer segment
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P02699
Sequence	>8P12_nogp_Chain_R M G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H K K L R T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G Y F V F G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K P M S N F R F G E N H A I M G V A F T W V M A L A C A A P P L V G W S R Y I P E G M Q C S C G I D Y Y T P H E E T N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q Q E S A T T Q K A E K E V T R M V I I V I A F L I C W L P Y A G V A F Y I F T H Q G S F G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q F R N C M C Y C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8P13	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.2	2024-11-20	To be published
	8P13 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.2	2024-11-20	To be published
	8P15	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.9	2024-11-20	To be published
	8P15 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.9	2024-11-20	To be published
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	doi.org/10.1073/pnas.1718084115
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol		2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol		2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PEL (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol		3.19	2020-06-24	To be published
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.6	2006-09-02	doi.org/10.1002/anie.200600595
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4J4Q (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-		2.65	2013-10-30	doi.org/10.1002/anie.201302374
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	doi.org/10.1016/j.bpj.2010.08.003
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	doi.org/10.1016/j.cell.2017.07.002
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	doi.org/10.1016/j.jmb.2004.07.044
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	doi.org/10.1016/j.jmb.2004.08.090
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	doi.org/10.1016/j.jmb.2007.03.007
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OY9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4X1H (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-		2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	doi.org/10.1021/bi0155091
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	doi.org/10.1038/embor.2013.44
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	4BEY (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	doi.org/10.1038/nature06925
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	doi.org/10.1038/nature07063
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3DQB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	3PQR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.85	2011-03-09	doi.org/10.1038/nature09789
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	3	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	2X72 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3	2011-03-16	doi.org/10.1038/nature09795
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	doi.org/10.1038/nature14656
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Arrestin1 Finger Loop	2.75	2014-09-17	doi.org/10.1038/ncomms5801
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	5WKT (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	9EPP	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPP (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/β1/γ2	4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	6CMO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-		4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	5.8	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	7	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4.1	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	doi.org/10.1038/sdata.2016.21
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.8	2006-08-22	doi.org/10.1073/pnas.0601765103
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	doi.org/10.1073/pnas.0608022103
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	doi.org/10.1073/pnas.082666399
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	4A4M (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	-	2.7	2017-03-15	doi.org/10.1073/pnas.1617446114
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	doi.org/10.1073/pnas.1617446114
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	doi.org/10.1073/pnas.1902192116
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	doi.org/10.1074/jbc.C800040200
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	doi.org/10.1074/jbc.RA119.010089
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	doi.org/10.1107/S0907444908017162
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	doi.org/10.1107/S0907444908017162
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Go	3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	6FUF (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	doi.org/10.1126/science.289.5480.739
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2015-06-17	doi.org/10.1371/journal.pone.0126970
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.3	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.81	2016-08-10	doi.org/10.15252/embr.201642671
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	doi.org/10.1529/biophysj.107.108225
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gi1/β1/γ1	4.38	2019-07-10	doi.org/10.7554/eLife.46041
	6QNO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.38	2019-07-10	doi.org/10.7554/eLife.46041
	9EPR	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-	Gi1/β1/γ2	4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-		4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6NWE (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		2.71	2020-02-12	To be published
	8P12	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	3.21	2024-11-20	To be published
	8P12 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.21	2024-11-20	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8P12_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.