Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F9 7.72527
2R:R:V20 6.075446
3R:R:S22 8.3575425
4R:R:F24 6.03143725
5R:R:Y29 5.93484
6R:R:Y30 9.1175444
7R:R:F37 3.862585
8R:R:F52 3.2775406
9R:R:V61 4.0025457
10R:R:T62 3.37407
11R:R:H65 5.902555
12R:R:I75 3.735407
13R:R:N78 4.57333639
14R:R:F91 5.985407
15R:R:F103 4.62628
16R:R:V104 4.6175424
17R:R:F105 5.09527
18R:R:F115 2.655436
19R:R:E122 8.5775416
20R:R:I123 3.51637
21R:R:L125 5.518517
22R:R:W126 7.98571715
23R:R:V129 4.244517
24R:R:L131 8.3154129
25R:R:Y136 6.545147
26R:R:F148 3.52833607
27R:R:W161 3.45333639
28R:R:P170 6.2525417
29R:R:W175 7.1775415
30R:R:Y178 8.7175403
31R:R:P180 5.775423
32R:R:M183 4.8675402
33R:R:C187 4.42429
34R:R:D190 5.4525414
35R:R:Y191 8.2375406
36R:R:Y192 7.045415
37R:R:T193 6.215415
38R:R:N200 4.6414
39R:R:F203 6.185616
40R:R:Y206 4.725414
41R:R:M207 7.084515
42R:R:H211 6.8675816
43R:R:F212 3.118518
44R:R:P215 4.3125419
45R:R:L216 4.3675417
46R:R:Y223 4.2625409
47R:R:E247 6.0475407
48R:R:V250 1.5725468
49R:R:Y257 7.3975408
50R:R:F261 3.638509
51R:R:W265 4.984518
52R:R:Y268 6.252516
53R:R:F283 6.284574
54R:R:F293 4.13754105
55R:R:Y306 9.44509
56R:R:F313 5.225458
57R:R:C316 4.9175455
58R:R:N326 6.755653
59L:L:?1 5.61778910
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:Q28 R:R:Y30 15.808314.65NoYes454
2R:R:P23 R:R:Q28 19.704812.63NoNo055
3R:R:P23 R:R:Q184 18.12364.74NoNo053
4R:R:P180 R:R:Q184 22.60757.9YesNo033
5R:R:C187 R:R:P180 31.66555.65YesYes293
6R:R:C187 R:R:G188 86.28121.96YesNo095
7R:R:E181 R:R:G188 87.04544.91NoNo045
8R:R:E181 R:R:Y192 88.5893.37NoYes045
9R:R:P27 R:R:Y102 26.42511.13NoNo084
10R:R:V104 R:R:Y102 27.50923.79YesNo244
11R:R:F105 R:R:V104 29.95635.24YesYes274
12R:R:F103 R:R:F105 41.84179.65YesYes287
13R:R:F103 R:R:F24 12.91694.29YesYes285
14R:R:P27 R:R:Y29 22.65272.78NoYes084
15R:R:F37 R:R:Y29 13.42528.25YesYes854
16R:R:Y191 R:R:Y192 95.384418.86YesYes065
17L:L:?1 R:R:Y191 1005.46YesYes006
18L:L:?1 R:R:K296 68.24417.5YesNo007
19R:R:F91 R:R:K296 67.23892.48YesNo077
20R:R:F91 R:R:L47 11.35087.31YesNo077
21R:R:F91 R:R:V87 51.90127.87YesNo076
22R:R:F52 R:R:V87 50.74925.24YesNo066
23R:R:F52 R:R:F88 47.24795.36YesNo064
24R:R:F88 R:R:L84 46.06582.44NoNo047
25R:R:L84 R:R:N55 44.87616.87NoNo079
26R:R:D83 R:R:N55 36.33768.08NoNo099
27R:R:D83 R:R:P303 33.83038.05NoNo099
28R:R:I307 R:R:P303 31.29281.69NoNo079
29R:R:F313 R:R:I307 28.72526.28YesNo087
30R:R:F313 R:R:V61 17.9092.62YesYes587
31R:R:H65 R:R:V61 12.45015.54YesYes557
32L:L:?1 R:R:W265 72.90112.27YesYes108
33R:R:F261 R:R:W265 58.13196.01YesYes098
34R:R:F261 R:R:L128 40.58053.65YesNo098
35R:R:L128 R:R:Y306 39.582914.07NoYes089
36R:R:L131 R:R:Y306 30.20868.21YesYes099
37R:R:E134 R:R:L131 28.08153.98NoYes1289
38R:R:E134 R:R:L72 28.22082.65NoNo088
39R:R:F148 R:R:L72 26.71494.87YesNo078
40R:R:I189 R:R:Y191 26.34214.84NoYes046
41R:R:I189 R:R:Y178 24.92282.42NoYes043
42R:R:F115 R:R:Y178 23.01412.06YesYes063
43R:R:F115 R:R:L119 18.23663.65YesNo365
44R:R:I123 R:R:L119 18.05594.28YesNo375
45R:R:I123 R:R:N78 10.73344.25YesYes379
46R:R:I75 R:R:N78 13.06382.83YesYes079
47L:L:?1 R:R:M207 39.533910.34YesYes105
48R:R:H211 R:R:M207 33.13387.88YesYes165
49R:R:H211 R:R:W126 25.70974.23YesYes165
50R:R:V129 R:R:W126 18.98589.81YesYes175
51R:R:I75 R:R:V130 11.143.07YesNo077
52R:R:I75 R:R:L131 16.4222.85YesYes079
53R:R:H211 R:R:L125 14.1332.57YesYes167
54R:R:F261 R:R:L125 21.0152.44YesYes097
55R:R:L125 R:R:P215 14.98764.93YesYes179
56R:R:I133 R:R:V129 11.45623.07NoYes167
57R:R:I219 R:R:Y223 23.56372.42NoYes089
58R:R:I219 R:R:L216 25.61182.85NoYes187
59R:R:F212 R:R:L216 21.63992.44YesYes187
60R:R:F208 R:R:F212 10.87273.22NoYes158
61L:L:?1 R:R:F208 13.36123.24YesNo105
62R:R:F212 R:R:W265 14.54332YesYes188
63R:R:F261 R:R:L216 15.69543.65YesYes097
64R:R:C222 R:R:Y136 11.06099.41NoYes087
65R:R:C222 R:R:I133 12.61581.64NoNo086
66R:R:V271 R:R:Y191 22.20093.79NoYes056
67R:R:I214 R:R:P215 17.50243.39NoYes059
68R:R:I214 R:R:V209 14.60361.54NoNo055
69R:R:I205 R:R:V209 11.69721.54NoNo055
70R:R:V254 R:R:Y223 19.05736.31NoYes089
71R:R:C264 R:R:W265 35.136711.75NoYes088
72R:R:C264 R:R:S298 33.87926.89NoNo089
73R:R:S298 R:R:Y301 32.61437.63NoNo095
74R:R:I263 R:R:Y301 24.86644.84NoNo055
75R:R:I259 R:R:I263 23.54872.94NoNo055
76R:R:I255 R:R:I259 22.22351.47NoNo055
77R:R:I255 R:R:T251 20.89071.52NoNo056
78R:R:E247 R:R:T251 19.55052.82YesNo076
79R:R:A234 R:R:Q244 14.11414.55NoNo054
80R:R:E247 R:R:Q244 15.48453.82YesNo074
81R:R:A234 R:R:T243 12.73621.68NoNo055
82R:R:S240 R:R:T243 11.35086.4NoNo045
83R:R:I275 R:R:V271 25.74731.54NoNo045
84R:R:F283 R:R:I275 20.64233.77YesNo744
85R:R:H278 R:R:T277 10.42099.58NoNo035
86R:R:C187 R:R:F103 53.87772.79YesYes298
87R:R:F203 R:R:S176 15.40552.64YesNo165
88R:R:F203 R:R:M207 18.89549.95YesYes165
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 2.48 0 Yes No 7 7 2 1
L:L:?1 R:R:T118 4.9 1 Yes No 0 4 0 1
R:R:C167 R:R:M207 4.86 1 No Yes 5 5 2 1
R:R:C167 R:R:H211 5.9 1 No Yes 5 6 2 2
R:R:I189 R:R:Y191 4.84 0 No Yes 4 6 2 1
R:R:F203 R:R:I189 3.77 1 Yes No 6 4 2 2
R:R:Y191 R:R:Y192 18.86 0 Yes Yes 6 5 1 2
R:R:V271 R:R:Y191 3.79 0 No Yes 5 6 2 1
L:L:?1 R:R:Y191 5.46 1 Yes Yes 0 6 0 1
R:R:F203 R:R:Y206 2.06 1 Yes Yes 6 4 2 2
R:R:F203 R:R:M207 9.95 1 Yes Yes 6 5 2 1
R:R:M207 R:R:Y206 2.39 1 Yes Yes 5 4 1 2
R:R:H211 R:R:Y206 4.36 1 Yes Yes 6 4 2 2
R:R:H211 R:R:M207 7.88 1 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 10.34 1 Yes Yes 0 5 0 1
R:R:F208 R:R:F212 3.22 1 No Yes 5 8 1 2
R:R:F208 R:R:I213 8.79 1 No No 5 4 1 2
L:L:?1 R:R:F208 3.24 1 Yes No 0 5 0 1
R:R:F212 R:R:I213 3.77 1 Yes No 8 4 2 2
R:R:F212 R:R:W265 2 1 Yes Yes 8 8 2 1
R:R:F261 R:R:W265 6.01 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 11.75 0 No Yes 8 8 2 1
R:R:W265 R:R:Y268 2.89 1 Yes Yes 8 6 1 1
L:L:?1 R:R:W265 2.27 1 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 5.56 0 No Yes 6 6 2 1
R:R:A292 R:R:Y268 4 0 No Yes 5 6 2 1
R:R:A295 R:R:Y268 4 0 No Yes 8 6 2 1
L:L:?1 R:R:Y268 14.81 1 Yes Yes 0 6 0 1
R:R:P291 R:R:V271 3.53 0 No No 6 5 2 2
L:L:?1 R:R:K296 7.5 1 Yes No 0 7 0 1
L:L:?1 R:R:A272 1.05 1 Yes No 0 5 0 1
L:L:?1 R:R:V204 0.99 1 Yes No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6QNO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 1.96
Number of Linked Nodes 314
Number of Links 380
Number of Hubs 59
Number of Links mediated by Hubs 218
Number of Communities 14
Number of Nodes involved in Communities 101
Number of Links involved in Communities 144
Path Summary
Number Of Nodes in MetaPath 89
Number Of Links MetaPath 88
Number of Shortest Paths 70095
Length Of Smallest Path 3
Average Path Length 14.101
Length of Longest Path 35
Minimum Path Strength 1.02
Average Path Strength 5.49062
Maximum Path Strength 16.555
Minimum Path Correlation 0.71
Average Path Correlation 0.949511
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 59.7899
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.8674
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein-containing complex binding   • binding   • protein binding   • enzyme binding   • GTPase binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • protein localization   • localization   • cellular localization   • cellular macromolecule localization   • macromolecule localization   • cellular developmental process   • photoreceptor cell differentiation   • cell development   • eye morphogenesis   • neurogenesis   • neuron differentiation   • cell differentiation   • eye photoreceptor cell differentiation   • animal organ morphogenesis   • photoreceptor cell development   • eye photoreceptor cell development   • nervous system development   • generation of neurons   • anatomical structure morphogenesis   • sensory organ morphogenesis   • neuron development   • phototransduction   • detection of light stimulus   • response to light stimulus   • detection of external stimulus   • response to external stimulus   • detection of abiotic stimulus   • detection of stimulus   • response to abiotic stimulus   • response to radiation   • opsin binding   • arrestin family protein binding   • G protein-coupled photoreceptor activity   • molecular transducer activity   • photoreceptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • vitamin binding   • retinal binding   • isoprenoid binding   • retinoid binding   • lipid binding   • 11-cis retinal binding   • small molecule binding   • G-protein alpha-subunit binding   • enzyme regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • GDP binding   • purine ribonucleotide binding   • ion binding   • anion binding   • molecular function regulator activity   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • nucleoside-triphosphatase regulator activity   • GTPase regulator activity   • purine ribonucleoside triphosphate binding   • guanyl-nucleotide exchange factor activity   • nucleoside phosphate binding   • purine nucleotide binding   • cation binding   • transition metal ion binding   • zinc ion binding   • metal ion binding   • identical protein binding   • rod bipolar cell differentiation   • neural retina development   • camera-type eye morphogenesis   • retinal bipolar neuron differentiation   • glutamatergic neuron differentiation   • retina morphogenesis in camera-type eye   • cellular response to light stimulus   • cellular response to radiation   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • detection of visible light   • G protein-coupled opsin signaling pathway   • phototransduction, visible light   • response to light intensity   • podosome assembly   • organelle assembly   • protein-containing complex organization   • membraneless organelle assembly   • cellular component organization   • cellular component biogenesis   • organelle organization   • cellular component assembly   • protein-containing complex assembly   • cellular component organization or biogenesis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • multicellular organismal-level homeostasis   • homeostatic process   • anatomical structure homeostasis   • tissue homeostasis   • retina homeostasis   • photoreceptor cell maintenance   • absorption of visible light   • light absorption   • microtubule cytoskeleton organization   • microtubule-based process   • cytoskeleton organization   • sensory perception of light stimulus   • visual perception   • thermoception   • sensory perception of temperature stimulus   • detection of temperature stimulus involved in sensory perception   • response to temperature stimulus   • detection of temperature stimulus involved in thermoception   • detection of temperature stimulus   • detection of stimulus involved in sensory perception   • taxis   • thermotaxis   • locomotion   • cell-cell junction   • anchoring junction   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • receptor complex   • sperm midpiece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • photoreceptor inner segment membrane   • plasma membrane region   • photoreceptor inner segment   • ciliary membrane   • photoreceptor outer segment membrane   • cell projection membrane   • Golgi membrane   • outer membrane   • sperm head   • sperm head plasma membrane   • sperm plasma membrane   • rod photoreceptor outer segment
SCOP2Domain Identifier• Ras-like P-loop GTPases   • WD40 repeat-like   • G protein-coupled receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • WD40 repeat-like   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeRET
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeRET
NameRETINAL
Synonyms
Identifier
FormulaC20 H28 O
Molecular Weight284.436
SMILES
PubChem638015
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP02699
Sequence
>6QNO_nogp_Chain_R
CGTEGPNFY VPFSNKTGV VRSPFEAPQ YYLAEPWQF SMLAAYMFL 
LIMLGFPIN FLTLYVTVQ HKKLRTPLN YILLNLAVA DLFMVFGGF 
TTTLYTSLH GYFVFGPTG CNLEGFFAT LGGEIALWS LVVLAIERY 
VVVCKPMSN FRFGENHAI MGVAFTWVM ALACAAPPL VGWSRYIPE 
GMQCSCGID YYTPHEETN NESFVIYMF VVHFIIPLI VIFFCYGQL 
VFTVKEAAA QQQESATTQ KAEKEVTRM VIIYVIAFL ICWLPYAGV 
AFYIFTHQG SCFGPIFMT IPAFFAKTS AVYNPVIYI MMNKQFRNC 
MVTTLCCGK NPLGDDEAS T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8P15ASensoryOpsinRhodopsinBos taurus--Gi1/β1/γT15.92024-11-20To be published
8P15 (No Gprot) ASensoryOpsinRhodopsinBos taurus--5.92024-11-20To be published
8P13ASensoryOpsinRhodopsinBos taurus--Gi1/β1/γT15.22024-11-20To be published
8P13 (No Gprot) ASensoryOpsinRhodopsinBos taurus--5.22024-11-20To be published
8P12ASensoryOpsinsRhodopsinBos taurus--Gi1/β1/γT13.212024-11-20To be published
8P12 (No Gprot) ASensoryOpsinsRhodopsinBos taurus--3.212024-11-20To be published
9EPRASensoryOpsinsRhodopsinHasarius adansoniRetinal-Gi1/β1/γ24.92024-10-30doi.org/10.1038/s41467-024-53208-2
9EPR (No Gprot) ASensoryOpsinsRhodopsinHasarius adansoniRetinal-4.92024-10-30doi.org/10.1038/s41467-024-53208-2
9EPQASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ24.152024-10-2310.1038/s41467-024-53208-2
9EPQ (No Gprot) ASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-4.152024-10-2310.1038/s41467-024-53208-2
9EPPASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ24.062024-10-2310.1038/s41467-024-53208-2
9EPP (No Gprot) ASensoryOpsinsRhodopsinHasarius adansoni11,20-Ethanoretinal-4.062024-10-2310.1038/s41467-024-53208-2
8FD1ASensoryOpsinsRhodopsinBos taurus---4.252023-08-3010.1038/s41467-023-40911-9
8FD1 (Multimeric) ASensoryOpsinsRhodopsinBos taurus--4.252023-08-3010.1038/s41467-023-40911-9
8FD0ASensoryOpsinsRhodopsinBos taurus---3.712023-08-3010.1038/s41467-023-40911-9
8FD0 (Multimeric) ASensoryOpsinsRhodopsinBos taurus--3.712023-08-3010.1038/s41467-023-40911-9
8FCZASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-3010.1038/s41467-023-40911-9
8FCZ (Multimeric) ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal-3.72023-08-3010.1038/s41467-023-40911-9
8A6EASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6DASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6CASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7ZBEASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7ZBCASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7MTBASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK142021-07-0710.1038/s41586-021-03721-x
7MTB (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-42021-07-0710.1038/s41586-021-03721-x
7MTAASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK14.12021-07-0710.1038/s41586-021-03721-x
7MTA (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-4.12021-07-0710.1038/s41586-021-03721-x
7MT9ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK172021-07-0710.1038/s41586-021-03721-x
7MT9 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-72021-07-0710.1038/s41586-021-03721-x
7MT8ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-GRK15.82021-07-0710.1038/s41586-021-03721-x
7MT8 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-5.82021-07-0710.1038/s41586-021-03721-x
6PH7ASensoryOpsinsRhodopsinBos taurus-NerolGt(CT)2.92020-07-01To be published
6PH7 (No Gprot) ASensoryOpsinsRhodopsinBos taurus-Nerol2.92020-07-01To be published
6PGSASensoryOpsinsRhodopsinBos taurus-GeraniolGt(CT)2.92020-07-01To be published
6PGS (No Gprot) ASensoryOpsinsRhodopsinBos taurus-Geraniol2.92020-07-01To be published
6PELASensoryOpsinsRhodopsinBos taurus-CitronellolGt(CT)3.192020-06-24To be published
6PEL (No Gprot) ASensoryOpsinsRhodopsinBos taurus-Citronellol3.192020-06-24To be published
6NWEASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)2.712020-02-12To be published
6NWE (No Gprot) ASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-2.712020-02-12To be published
6OFJASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
6OFJ (Multimeric) ASensoryOpsinsRhodopsinBos taurus--4.52019-08-2110.1074/jbc.RA119.010089
6OYAASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt/β1/γ13.32019-07-2410.1016/j.molcel.2019.06.007
6OYA (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.32019-07-2410.1016/j.molcel.2019.06.007
6OY9ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt/β1/γ13.92019-07-2410.1016/j.molcel.2019.06.007
6OY9 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.92019-07-2410.1016/j.molcel.2019.06.007
6QNOASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gi1/β1/γ14.382019-07-1010.7554/eLife.46041
6QNO (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-4.382019-07-1010.7554/eLife.46041
6I9KASensoryOpsinsRhodopsinHasarius adansoni9-cis-Retinal--2.152019-07-0310.1073/pnas.1902192116
6FUFASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Go3.122018-10-0310.1126/sciadv.aat7052
6FUF (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.122018-10-0310.1126/sciadv.aat7052
6CMOASensoryOpsinsRhodopsinHomo sapiens--Gi1/β1/γ24.52018-06-2010.1038/s41586-018-0215-y
6CMO (No Gprot) ASensoryOpsinsRhodopsinHomo sapiens--4.52018-06-2010.1038/s41586-018-0215-y
6FKDASensoryOpsinsRhodopsinBos taurus-PubChem 137349183-2.492018-04-0410.1073/pnas.1718084115
6FKCASensoryOpsinsRhodopsinBos taurus-PubChem 132473039-2.462018-04-0410.1073/pnas.1718084115
6FKBASensoryOpsinsRhodopsinBos taurus-PubChem 132473038-3.032018-04-0410.1073/pnas.1718084115
6FKAASensoryOpsinsRhodopsinBos taurus-PubChem 132473037-2.72018-04-0410.1073/pnas.1718084115
6FK9ASensoryOpsinsRhodopsinBos taurus-PubChem 132473036-2.632018-04-0410.1073/pnas.1718084115
6FK8ASensoryOpsinsRhodopsinBos taurus-PubChem 132473035-2.872018-04-0410.1073/pnas.1718084115
6FK7ASensoryOpsinsRhodopsinBos taurus-PubChem 132473034-2.622018-04-0410.1073/pnas.1718084115
6FK6ASensoryOpsinsRhodopsinBos taurus-PubChem 132473033-2.362018-04-0410.1073/pnas.1718084115
5WKTASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)3.22017-12-1310.1038/nprot.2017.135
5WKT (No Gprot) ASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-3.22017-12-1310.1038/nprot.2017.135
5W0PASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.012017-08-0910.1016/j.cell.2017.07.002
5TE5ASensoryOpsinsRhodopsinBos taurus20-Methanoretinal--4.012017-03-1510.1073/pnas.1617446114
5TE3ASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside--2.72017-03-1510.1073/pnas.1617446114
5DYSASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--2.32016-08-1010.15252/embr.201642671
5EN0ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.812016-08-1010.15252/embr.201642671
5EN0 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-2.812016-08-1010.15252/embr.201642671
5DGYASensoryOpsinsRhodopsinHomo sapiens--Arrestin17.72016-03-2310.1038/sdata.2016.21
4X1HASensoryOpsinsRhodopsinBos taurusNonyl-β-D-Glucopyranoside-Gt(CT)2.292015-11-0410.1016/j.str.2015.09.015
4X1H (No Gprot) ASensoryOpsinsRhodopsinBos taurusNonyl-β-D-Glucopyranoside-2.292015-11-0410.1016/j.str.2015.09.015
4ZWJASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.32015-07-2910.1038/nature14656
4WW3ASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-Retinal--2.82015-06-1710.1371/journal.pone.0126970
4PXFASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Arrestin1 Finger Loop2.752014-09-1710.1038/ncomms5801
4J4QASensoryOpsinsRhodopsinBos taurusOctyl β-D-Glucopyranoside-Gt(CT)2.652013-10-3010.1002/anie.201302374
4J4Q (No Gprot) ASensoryOpsinsRhodopsinBos taurusOctyl β-D-Glucopyranoside-2.652013-10-3010.1002/anie.201302374
4BEYASensoryOpsinsRhodopsinBos taurus--Gt(CT)2.92013-05-0810.1038/embor.2013.44
4BEY (No Gprot) ASensoryOpsinsRhodopsinBos taurus--2.92013-05-0810.1038/embor.2013.44
4BEZASensoryOpsinsRhodopsinBos taurus---3.32013-04-2410.1038/embor.2013.44
4A4MASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)3.32012-01-2510.1073/pnas.1114089108
4A4M (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-3.32012-01-2510.1073/pnas.1114089108
3AYNASensoryOpsinsRhodopsinTodarodes pacificus9-cis-Retinal--2.72011-08-1710.1016/j.jmb.2011.08.044
3AYMASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-Retinal--2.82011-08-1710.1016/j.jmb.2011.08.044
2X72ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)32011-03-1610.1038/nature09795
2X72 (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-32011-03-1610.1038/nature09795
3PXOASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--32011-03-0910.1038/nature09789
3PQRASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.852011-03-0910.1038/nature09789
3PQR (No Gprot) ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-2.852011-03-0910.1038/nature09789
3OAXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62011-01-1910.1016/j.bpj.2010.08.003
3DQBASensoryOpsinsRhodopsinBos taurus--Gt(CT)3.22008-09-2310.1038/nature07330
3DQB (No Gprot) ASensoryOpsinsRhodopsinBos taurus--3.22008-09-2310.1038/nature07330
3C9MASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42008-08-0510.1107/S0907444908017162
3C9LASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652008-08-0510.1107/S0907444908017162
3CAPASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
3CAP (Multimeric) ASensoryOpsinsRhodopsinBos taurus--2.92008-06-2410.1038/nature07063
2Z73ASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--2.52008-05-1310.1038/nature06925
2ZIYASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--3.72008-05-0610.1074/jbc.C800040200
2PEDASensoryOpsinsRhodopsinBos taurus9-cis-Retinal--2.952007-10-3010.1529/biophysj.107.108225
2J4YASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42007-09-2510.1016/j.jmb.2007.03.007
2I37ASensoryOpsinsRhodopsinBos taurus---4.152006-10-1710.1073/pnas.0608022103
2I36ASensoryOpsinsRhodopsinBos taurus---4.12006-10-1710.1073/pnas.0608022103
2I35ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.82006-10-1710.1073/pnas.0608022103
2G87ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--2.62006-09-0210.1002/anie.200600595
2HPYASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal--2.82006-08-2210.1073/pnas.0601765103
1U19ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.22004-10-1210.1016/j.jmb.2004.07.044
1GZMASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652003-11-2010.1016/j.jmb.2004.08.090
1L9HASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62002-05-1510.1073/pnas.082666399
1HZXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82001-07-0410.1021/bi0155091
1F88ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82000-08-0410.1126/science.289.5480.739




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Download 6QNO_nogp.zip



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