psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D282	R:R:N2	13.46	No	No	0	2	6
2	R:R:G3	R:R:Y10	4.35	No	No	0	6	7
3	R:R:N15	R:R:T4	8.77	Yes	No	4	7	6
4	R:R:T4	R:R:V20	9.52	No	Yes	4	6	6
5	H:H:?1	R:R:T4	5.29	Yes	No	4	0	6
6	R:R:G6	R:R:P7	4.06	No	No	0	6	6
7	R:R:F9	R:R:G6	9.03	No	No	0	7	6
8	R:R:N8	R:R:P107	4.89	No	No	0	4	3
9	R:R:F9	R:R:S22	6.61	No	No	0	7	5
10	R:R:F9	R:R:P23	15.89	No	Yes	0	7	5
11	R:R:T193	R:R:Y10	6.24	Yes	No	0	5	7
12	R:R:V11	R:R:V20	4.81	No	Yes	0	8	6
13	R:R:P12	R:R:Q184	4.74	No	Yes	0	8	3
14	R:R:P12	R:R:P285	5.84	No	Yes	0	8	3
15	R:R:F13	R:R:Y30	7.22	No	Yes	0	4	4
16	R:R:K16	R:R:S14	9.18	No	No	0	7	4
17	R:R:G18	R:R:N15	5.09	No	Yes	4	3	7
18	R:R:N15	R:R:V20	10.35	Yes	Yes	4	7	6
19	H:H:?1	R:R:N15	24.64	Yes	Yes	4	0	7
20	R:R:T17	R:R:V19	6.35	No	No	0	6	3
21	H:H:?1	R:R:G18	6.14	Yes	No	4	0	3
22	R:R:V19	R:R:Y30	5.05	No	Yes	0	3	4
23	R:R:V20	R:R:Y30	12.62	Yes	Yes	0	6	4
24	H:H:?1	R:R:V20	5.35	Yes	Yes	4	0	6
25	H:H:?2	R:R:R21	6.54	No	No	0	0	4
26	R:R:F24	R:R:S22	3.96	Yes	No	0	5	5
27	R:R:E25	R:R:S22	5.75	No	No	0	7	5
28	R:R:P23	R:R:Q28	4.74	Yes	Yes	2	5	5
29	R:R:P180	R:R:P23	7.79	Yes	Yes	2	3	5
30	R:R:P23	R:R:Q184	7.9	Yes	Yes	2	5	3
31	R:R:F24	R:R:G106	6.02	Yes	No	2	5	8
32	R:R:F24	R:R:P107	13	Yes	No	2	5	3
33	R:R:C110	R:R:F24	5.59	Yes	Yes	2	9	5
34	R:R:F24	R:R:P180	8.67	Yes	Yes	2	5	3
35	R:R:P27	R:R:Y29	11.13	No	Yes	0	8	4
36	R:R:P27	R:R:Y102	6.95	No	No	0	8	4
37	R:R:Q28	R:R:Y30	10.15	Yes	Yes	0	5	4
38	R:R:L31	R:R:Q28	5.32	No	Yes	0	4	5
39	R:R:Q184	R:R:Q28	6.4	Yes	Yes	2	3	5
40	R:R:P34	R:R:Y29	13.91	No	Yes	0	3	4
41	R:R:F37	R:R:Y29	7.22	Yes	Yes	5	5	4
42	R:R:G101	R:R:Y29	4.35	No	Yes	5	4	4
43	R:R:L31	R:R:P285	9.85	No	Yes	0	4	3
44	R:R:A32	R:R:Q36	4.55	No	Yes	0	3	2
45	R:R:A32	R:R:F37	4.16	No	Yes	0	3	5
46	R:R:E33	R:R:W35	5.45	No	No	6	3	3
47	R:R:E33	R:R:Q36	6.37	No	Yes	6	3	2
48	R:R:Q36	R:R:W35	16.43	Yes	No	6	2	3
49	R:R:I286	R:R:Q36	4.12	No	Yes	0	1	2
50	R:R:F37	R:R:G101	4.52	Yes	No	5	5	4
51	R:R:F37	R:R:M183	9.95	Yes	No	0	5	2
52	R:R:L40	R:R:S98	4.5	No	No	0	5	5
53	R:R:L47	R:R:Y43	9.38	No	No	1	7	4
54	R:R:F293	R:R:Y43	9.28	No	No	0	5	4
55	R:R:T297	R:R:Y43	6.24	No	No	1	6	4
56	R:R:F91	R:R:M44	3.73	Yes	No	0	7	7
57	R:R:M44	R:R:T94	6.02	No	No	0	7	7
58	R:R:F45	R:R:M49	12.44	No	No	0	3	5
59	R:R:L46	R:R:L50	4.15	No	No	0	5	5
60	R:R:F91	R:R:L47	13.4	Yes	No	0	7	7
61	R:R:L47	R:R:T297	4.42	No	No	1	7	6
62	R:R:I48	R:R:T92	4.56	No	No	0	6	8
63	R:R:L50	R:R:V300	4.47	No	No	0	5	7
64	R:R:F52	R:R:P53	5.78	No	No	0	6	4
65	R:R:F52	R:R:F56	8.57	No	No	0	6	4
66	R:R:F52	R:R:F88	5.36	No	No	0	6	4
67	R:R:D83	R:R:N55	13.46	Yes	Yes	7	9	9
68	R:R:L84	R:R:N55	4.12	No	Yes	0	7	9
69	R:R:N55	R:R:P303	8.15	Yes	No	7	9	9
70	R:R:L57	R:R:M317	11.31	No	No	0	6	6
71	R:R:I307	R:R:T58	12.16	No	No	0	7	9
72	R:R:Q64	R:R:Y60	10.15	No	No	0	5	3
73	R:R:M317	R:R:V61	4.56	No	No	0	6	7
74	R:R:T320	R:R:V61	6.35	No	No	0	5	7
75	R:R:L68	R:R:T62	4.42	Yes	No	0	7	7
76	R:R:L77	R:R:T62	11.79	No	No	0	5	7
77	R:R:H65	R:R:L68	3.86	Yes	Yes	8	5	7
78	R:R:C316	R:R:H65	17.69	No	Yes	8	5	5
79	R:R:H65	R:R:T320	5.48	Yes	No	0	5	5
80	R:R:L68	R:R:Q312	3.99	Yes	No	0	7	6
81	R:R:F313	R:R:L68	14.61	Yes	Yes	0	8	7
82	R:R:C316	R:R:L68	7.94	No	Yes	8	5	7
83	R:R:N73	R:R:T70	5.85	No	No	0	8	7
84	R:R:F148	R:R:L72	8.53	Yes	No	0	7	8
85	R:R:F313	R:R:N73	8.46	Yes	No	0	8	8
86	R:R:E150	R:R:Y74	6.73	No	No	0	2	5
87	R:R:A153	R:R:Y74	5.34	No	No	0	7	5
88	R:R:I75	R:R:N78	4.25	Yes	Yes	3	7	9
89	R:R:I75	R:R:S127	6.19	Yes	No	3	7	8
90	R:R:I75	R:R:V130	6.14	Yes	No	0	7	7
91	R:R:I75	R:R:L131	4.28	Yes	No	0	7	9
92	R:R:I307	R:R:L76	5.71	No	No	0	7	8
93	R:R:I123	R:R:N78	4.25	Yes	Yes	0	7	9
94	R:R:N78	R:R:S127	5.96	Yes	No	3	9	8
95	R:R:N78	R:R:V157	5.91	Yes	No	3	9	7
96	R:R:N78	R:R:T160	7.31	Yes	No	3	9	7
97	R:R:N78	R:R:W161	4.52	Yes	No	3	9	9
98	R:R:D83	R:R:L79	5.43	Yes	No	0	9	9
99	R:R:A299	R:R:D83	4.63	No	Yes	0	9	9
100	R:R:D83	R:R:P303	6.44	Yes	No	7	9	9
101	R:R:F116	R:R:F85	5.36	No	No	0	4	6
102	R:R:F91	R:R:M86	3.73	Yes	No	0	7	7
103	R:R:G121	R:R:M86	5.24	No	No	0	7	7
104	R:R:A299	R:R:M86	4.83	No	No	0	9	7
105	R:R:F91	R:R:V87	5.24	Yes	No	0	7	6
106	R:R:F88	R:R:T92	5.19	No	No	0	4	8
107	R:R:F91	R:R:K296	8.69	Yes	No	0	7	7
108	R:R:S186	R:R:T94	6.4	No	No	0	5	7
109	R:R:H100	R:R:Y96	14.16	No	No	0	4	4
110	R:R:F105	R:R:Y96	7.22	Yes	No	0	7	4
111	R:R:C185	R:R:T97	5.07	No	No	0	5	5
112	R:R:H100	R:R:V104	8.3	No	No	0	4	4
113	R:R:V104	R:R:Y102	11.36	No	No	0	4	4
114	R:R:F103	R:R:F105	4.29	Yes	Yes	0	8	7
115	R:R:C110	R:R:F103	4.19	Yes	Yes	2	9	8
116	R:R:E113	R:R:F103	7	No	Yes	2	5	8
117	R:R:C187	R:R:F103	8.38	Yes	Yes	2	9	8
118	R:R:F105	R:R:V104	7.87	Yes	No	0	7	4
119	R:R:G106	R:R:P107	4.06	No	No	2	8	3
120	R:R:C110	R:R:P180	3.77	Yes	Yes	2	9	3
121	R:R:C110	R:R:C187	7.28	Yes	Yes	2	9	9
122	R:R:L172	R:R:N111	4.12	No	No	0	5	7
123	R:R:E113	R:R:S186	4.31	No	No	0	5	5
124	R:R:C187	R:R:E113	4.56	Yes	No	2	9	5
125	R:R:G114	R:R:Y178	5.79	No	No	0	5	3
126	R:R:F115	R:R:F116	9.65	No	No	0	6	4
127	R:R:F115	R:R:L172	6.09	No	No	0	6	5
128	R:R:T118	R:R:Y178	9.99	No	No	0	4	3
129	L:L:?405	R:R:T118	10.06	Yes	No	0	0	4
130	R:R:I123	R:R:L119	5.71	Yes	No	0	7	5
131	R:R:E122	R:R:L125	3.98	No	No	1	6	7
132	R:R:C167	R:R:E122	10.64	No	No	1	5	6
133	R:R:E122	R:R:H211	7.39	No	Yes	1	6	6
134	R:R:A164	R:R:I123	4.87	No	Yes	0	8	7
135	R:R:F261	R:R:L125	4.87	Yes	No	1	9	7
136	R:R:L125	R:R:W265	14.81	No	No	1	7	8
137	R:R:V129	R:R:W126	6.13	No	Yes	0	7	5
138	R:R:M163	R:R:W126	19.78	No	Yes	0	4	5
139	R:R:H211	R:R:W126	9.52	Yes	Yes	0	6	5
140	R:R:P215	R:R:W126	8.11	No	Yes	0	9	5
141	R:R:S127	R:R:T160	4.8	No	No	3	8	7
142	R:R:L128	R:R:N302	4.12	No	No	0	8	9
143	R:R:L128	R:R:Y306	16.41	No	No	0	8	9
144	R:R:E134	R:R:V130	5.7	No	No	0	8	7
145	R:R:L131	R:R:R135	17.01	No	No	0	9	9
146	R:R:A132	R:R:Y223	8.01	No	Yes	0	9	9
147	R:R:E134	R:R:F148	12.83	No	Yes	0	8	7
148	R:R:R135	R:R:Y223	9.26	No	Yes	0	9	9
149	R:R:C140	R:R:Y136	5.38	No	Yes	0	7	7
150	R:R:P142	R:R:Y136	9.74	No	Yes	0	8	7
151	R:R:F221	R:R:Y136	6.19	No	Yes	9	4	7
152	R:R:C222	R:R:Y136	6.72	No	Yes	0	8	7
153	R:R:Q225	R:R:Y136	5.64	No	Yes	9	4	7
154	R:R:F148	R:R:V138	3.93	Yes	No	0	7	8
155	R:R:L226	R:R:V139	7.45	No	No	0	8	8
156	R:R:C140	R:R:T229	5.07	No	No	0	7	6
157	R:R:F146	R:R:M143	8.71	No	No	0	5	6
158	R:R:F146	R:R:H152	11.31	No	No	0	5	5
159	R:R:V157	R:R:W161	7.36	No	No	3	7	9
160	R:R:F159	R:R:M163	9.95	No	No	0	3	4
161	R:R:C167	R:R:M207	4.86	No	Yes	1	5	5
162	R:R:C167	R:R:H211	11.79	No	Yes	1	5	6
163	R:R:P170	R:R:P171	7.79	Yes	No	1	7	5
164	R:R:P170	R:R:W175	4.05	Yes	Yes	1	7	5
165	R:R:F203	R:R:P170	4.33	Yes	Yes	1	6	7
166	R:R:P171	R:R:Y178	11.13	No	No	0	5	3
167	R:R:F203	R:R:P171	5.78	Yes	No	1	6	5
168	R:R:S202	R:R:W175	6.18	No	Yes	0	4	5
169	R:R:F203	R:R:W175	20.04	Yes	Yes	1	6	5
170	R:R:W175	R:R:Y206	9.65	Yes	Yes	1	5	4
171	R:R:N200	R:R:S176	4.47	Yes	No	0	4	5
172	R:R:F203	R:R:S176	10.57	Yes	No	0	6	5
173	R:R:I179	R:R:R177	8.77	No	Yes	1	1	5
174	R:R:D190	R:R:R177	14.29	Yes	Yes	1	4	5
175	R:R:H195	R:R:R177	27.08	Yes	Yes	1	4	5
176	R:R:R177	R:R:T198	5.17	Yes	Yes	1	5	1
177	R:R:D190	R:R:I179	9.8	Yes	No	1	4	1
178	R:R:I179	R:R:Y192	6.04	No	Yes	1	1	5
179	R:R:P180	R:R:Q184	6.32	Yes	Yes	2	3	3
180	R:R:C187	R:R:P180	5.65	Yes	Yes	2	9	3
181	R:R:E181	R:R:Y268	4.49	No	Yes	0	4	6
182	L:L:?405	R:R:G188	5.84	Yes	No	0	0	5
183	R:R:F203	R:R:I189	6.28	Yes	No	0	6	4
184	L:L:?405	R:R:I189	4.87	Yes	No	0	0	4
185	R:R:D190	R:R:Y192	6.9	Yes	Yes	1	4	5
186	R:R:D190	R:R:T193	13.01	Yes	Yes	1	4	5
187	R:R:D190	R:R:N200	8.08	Yes	Yes	1	4	4
188	R:R:Y191	R:R:Y192	10.92	Yes	Yes	1	6	5
189	R:R:Y191	R:R:Y268	5.96	Yes	Yes	1	6	6
190	R:R:V271	R:R:Y191	3.79	No	Yes	0	5	6
191	R:R:M288	R:R:Y191	5.99	No	Yes	1	4	6
192	L:L:?405	R:R:Y191	10	Yes	Yes	1	0	6
193	R:R:T193	R:R:Y192	3.75	Yes	Yes	1	5	5
194	R:R:M288	R:R:Y192	8.38	No	Yes	1	4	5
195	R:R:E196	R:R:P194	4.72	No	No	0	1	1
196	R:R:P194	R:R:Q279	7.9	No	No	0	1	1
197	R:R:E197	R:R:H195	20.92	No	Yes	0	3	4
198	R:R:H195	R:R:T198	9.58	Yes	Yes	1	4	1
199	R:R:H195	R:R:N200	5.1	Yes	Yes	1	4	4
200	R:R:N200	R:R:T198	5.85	Yes	Yes	1	4	1
201	R:R:E201	R:R:F276	9.33	No	No	0	3	4
202	R:R:F203	R:R:M207	6.22	Yes	Yes	1	6	5
203	R:R:F276	R:R:I205	5.02	No	No	0	4	5
204	R:R:V210	R:R:Y206	6.31	No	Yes	1	4	4
205	R:R:H211	R:R:Y206	9.8	Yes	Yes	1	6	4
206	R:R:H211	R:R:M207	3.94	Yes	Yes	1	6	5
207	L:L:?405	R:R:M207	7.24	Yes	Yes	1	0	5
208	R:R:F208	R:R:F212	5.36	No	Yes	1	5	8
209	R:R:F208	R:R:I213	6.28	No	No	1	5	4
210	R:R:H211	R:R:V210	11.07	Yes	No	1	6	4
211	R:R:F212	R:R:I213	3.77	Yes	No	1	8	4
212	R:R:A269	R:R:F212	8.32	No	Yes	0	7	8
213	L:L:?405	R:R:F212	4.16	Yes	Yes	1	0	8
214	R:R:I214	R:R:P215	6.77	No	No	0	5	9
215	R:R:F220	R:R:L216	6.09	No	No	0	5	7
216	R:R:F261	R:R:I219	7.54	Yes	No	0	9	8
217	R:R:F220	R:R:V258	3.93	No	No	0	5	8
218	R:R:F221	R:R:Q225	12.88	No	No	9	4	4
219	R:R:V254	R:R:Y223	7.57	No	Yes	0	8	9
220	R:R:M257	R:R:Y223	13.17	No	Yes	0	8	9
221	R:R:K231	R:R:V227	6.07	No	No	0	5	5
222	R:R:V227	R:R:V254	4.81	No	No	0	5	8
223	R:R:E247	R:R:K231	10.8	Yes	No	0	7	5
224	R:R:K231	R:R:T251	7.51	No	No	0	5	6
225	R:R:A234	R:R:Q244	4.55	No	No	0	5	4
226	R:R:E239	R:R:Q237	8.92	No	No	0	2	5
227	R:R:Q237	R:R:S240	4.33	No	No	10	5	4
228	R:R:Q237	R:R:T243	4.25	No	No	10	5	5
229	R:R:S240	R:R:T243	6.4	No	No	10	4	5
230	R:R:E249	R:R:R252	8.14	No	No	0	7	7
231	R:R:E249	R:R:M253	4.06	No	No	0	7	8
232	R:R:I256	R:R:R252	3.76	No	No	0	5	7
233	R:R:I256	R:R:I305	4.42	No	No	0	5	8
234	R:R:M257	R:R:Y306	11.97	No	No	0	8	9
235	R:R:F261	R:R:W265	4.01	Yes	No	1	9	8
236	R:R:F294	R:R:I263	3.77	No	No	0	7	5
237	R:R:C264	R:R:W265	10.45	No	No	1	8	8
238	R:R:C264	R:R:S298	5.16	No	No	1	8	9
239	R:R:C264	R:R:Y301	5.38	No	No	1	8	5
240	R:R:F294	R:R:P267	7.22	No	No	0	7	9
241	R:R:P291	R:R:Y268	12.52	No	Yes	0	6	6
242	L:L:?405	R:R:Y268	34	Yes	Yes	1	0	6
243	L:L:?405	R:R:A272	4.03	Yes	No	0	0	5
244	R:R:F273	R:R:T277	3.89	No	No	0	6	5
245	R:R:H278	R:R:Y274	26.13	No	No	0	3	4
246	R:R:F283	R:R:Y274	4.13	Yes	No	0	4	4
247	R:R:F283	R:R:I275	16.33	Yes	No	0	4	4
248	R:R:H278	R:R:T277	8.21	No	No	0	3	5
249	R:R:F283	R:R:F287	9.65	Yes	No	0	4	4
250	R:R:G284	R:R:P285	4.06	No	Yes	0	4	3
251	R:R:F287	R:R:M288	3.73	No	No	0	4	4
252	R:R:F293	R:R:F294	13.93	No	No	0	5	7
253	L:L:?405	R:R:K296	6.01	Yes	No	0	0	7
254	R:R:T297	R:R:Y301	4.99	No	No	1	6	5
255	R:R:S298	R:R:Y301	6.36	No	No	1	9	5
256	R:R:N302	R:R:S298	5.96	No	No	0	9	9
257	R:R:I305	R:R:Y306	6.04	No	No	0	8	9
258	R:R:F313	R:R:I307	6.28	Yes	No	0	8	7
259	R:R:F313	R:R:N310	9.67	Yes	No	0	8	8
260	H:H:?4	R:R:C323	8.35	No	No	0	0	9
261	R:R:G324	R:R:K325	5.23	No	No	0	3	3
262	H:H:?1	H:H:?2	33.43	Yes	No	0	0	0
263	H:H:?2	H:H:?3	28.57	No	No	0	0	0
264	H:H:?3	H:H:?5	29.87	No	No	0	0	0
265	R:R:M309	R:R:R252	3.72	No	No	0	7	7
266	R:R:H65	R:R:Q64	3.71	Yes	No	0	5	5
267	R:R:K66	R:R:R69	3.71	No	No	0	6	6
268	R:R:F115	R:R:L119	3.65	No	No	0	6	5
269	R:R:F261	R:R:L216	3.65	Yes	No	0	9	7
270	R:R:P71	R:R:T70	3.5	No	No	0	6	7
271	R:R:P194	R:R:T193	3.5	No	Yes	0	1	5
272	R:R:C185	R:R:S98	3.44	No	No	0	5	5
273	R:R:A41	R:R:S98	3.42	No	No	0	5	5
274	R:R:G109	R:R:L112	3.42	No	No	0	5	4
275	R:R:I54	R:R:P303	3.39	No	No	0	8	9
276	R:R:F148	R:R:H152	3.39	Yes	No	0	7	5
277	R:R:I290	R:R:P291	3.39	No	No	0	5	6
278	R:R:A80	R:R:T58	3.36	No	No	0	9	9
279	R:R:A168	R:R:T118	3.36	No	No	0	7	4
280	R:R:L266	R:R:P267	3.28	No	No	0	6	9
281	R:R:A82	R:R:I123	3.25	No	Yes	0	8	7
282	R:R:A42	R:R:M39	3.22	No	No	0	5	4
283	R:R:V129	R:R:V218	3.21	No	No	0	7	6
284	R:R:V230	R:R:V250	3.21	No	No	0	8	8
285	R:R:A41	R:R:L99	3.15	No	No	0	5	4
286	R:R:T94	R:R:T97	3.14	No	No	0	7	5
287	R:R:A80	R:R:N55	3.13	No	Yes	0	9	9
288	R:R:I48	R:R:V87	3.07	No	No	0	6	6
289	R:R:I133	R:R:V218	3.07	No	No	0	6	6
290	R:R:M143	R:R:V137	3.04	No	No	0	6	4
291	R:R:M163	R:R:V162	3.04	No	No	0	4	4
292	R:R:A234	R:R:E247	3.02	No	Yes	0	5	7
293	R:R:F103	R:R:G109	3.01	Yes	No	0	8	5
294	R:R:M183	R:R:T289	3.01	No	No	0	2	4
295	R:R:G149	R:R:R147	3	No	No	0	6	4
296	R:R:L59	R:R:V81	2.98	No	No	0	7	6
297	R:R:I213	R:R:I217	2.94	No	No	0	4	4
298	R:R:I255	R:R:I259	2.94	No	No	0	5	5
299	R:R:I259	R:R:I263	2.94	No	No	0	5	5
300	R:R:I48	R:R:L95	2.85	No	No	0	6	6
301	R:R:E247	R:R:V230	2.85	Yes	No	0	7	8
302	R:R:K325	R:R:N326	2.8	No	No	0	3	3
303	R:R:A26	R:R:R21	2.77	No	No	0	2	4
304	R:R:L321	R:R:L57	2.77	No	No	0	6	6
305	R:R:L119	R:R:L165	2.77	No	No	0	5	3
306	R:R:A153	R:R:F148	2.77	No	Yes	0	7	7
307	R:R:H65	R:R:T319	2.74	Yes	No	0	5	4
308	R:R:E150	R:R:I154	2.73	No	No	0	2	3
309	R:R:E247	R:R:K248	2.7	Yes	No	0	7	4
310	L:L:?405	R:R:A117	2.69	Yes	No	0	0	5
311	L:L:?405	R:R:A295	2.69	Yes	No	0	0	8
312	R:R:A292	R:R:Y268	2.67	No	Yes	0	5	6
313	R:R:F283	R:R:S281	2.64	Yes	No	0	4	4
314	R:R:F85	R:R:V81	2.62	No	No	0	6	6
315	R:R:R69	R:R:T62	2.59	No	No	0	6	7
316	R:R:F105	R:R:T93	2.59	Yes	No	0	7	5
317	R:R:Q238	R:R:Q244	2.56	No	No	0	5	4
318	R:R:V204	R:R:Y191	2.52	No	Yes	0	4	6
319	R:R:K311	R:R:R314	2.48	No	No	0	4	8
320	R:R:F45	R:R:L95	2.44	No	No	0	3	6
321	R:R:M39	R:R:W35	2.33	No	No	0	4	3
322	R:R:E232	R:R:F228	2.33	No	No	0	4	3
323	R:R:N199	R:R:W175	2.26	No	Yes	0	3	5
324	R:R:E5	R:R:Y10	2.24	No	No	0	6	7
325	R:R:G89	R:R:G90	2.11	No	No	0	4	6
326	R:R:G120	R:R:G121	2.11	No	No	0	8	7
327	R:R:G182	R:R:P285	2.03	No	Yes	0	3	3
328	R:R:A117	R:R:G90	1.95	No	No	0	5	6
329	R:R:A124	R:R:G121	1.95	No	No	0	9	7
330	R:R:A269	R:R:G270	1.95	No	No	0	7	5
331	R:R:A169	R:R:P170	1.87	No	Yes	0	3	7
332	R:R:G51	R:R:V300	1.84	No	No	0	8	7
333	R:R:G156	R:R:V130	1.84	No	No	0	6	7
334	R:R:G109	R:R:T108	1.82	No	No	0	5	1
335	R:R:G174	R:R:T198	1.82	No	Yes	0	5	1
336	R:R:G324	R:R:T319	1.82	No	No	0	3	4
337	R:R:A132	R:R:C222	1.81	No	No	0	9	8
338	R:R:C322	R:R:V318	1.71	No	No	0	4	3
339	R:R:G51	R:R:N55	1.7	No	Yes	0	8	9
340	R:R:A234	R:R:T243	1.68	No	No	0	5	5
341	R:R:D282	R:R:G284	1.68	No	No	0	2	4
342	R:R:K141	R:R:P142	1.67	No	No	0	6	8
343	R:R:G280	R:R:Q279	1.64	No	No	0	1	1
344	R:R:A260	R:R:I305	1.62	No	No	0	7	8
345	R:R:V139	R:R:V230	1.6	No	No	0	8	8
346	R:R:V209	R:R:V210	1.6	No	No	0	5	4
347	R:R:S240	R:R:T242	1.6	No	No	0	4	4
348	R:R:G149	R:R:H152	1.59	No	No	0	6	5
349	R:R:I205	R:R:V209	1.54	No	No	0	5	5
350	R:R:M308	R:R:V304	1.52	No	No	0	6	7
351	R:R:K16	R:R:T17	1.5	No	No	0	7	6
352	R:R:L172	R:R:V173	1.49	No	No	0	5	4
353	R:R:I54	R:R:M308	1.46	No	No	0	8	6
354	R:R:Q64	R:R:V63	1.43	No	No	0	5	2
355	R:R:K311	R:R:N315	1.4	No	No	0	4	5
356	H:H:?4	R:R:C322	1.39	No	No	0	0	4
357	R:R:L216	R:R:L262	1.38	No	No	0	7	6
358	R:R:K67	R:R:Q312	1.36	No	No	0	5	6
359	R:R:A166	R:R:Y206	1.33	No	Yes	0	4	4
360	R:R:R314	R:R:V318	1.31	No	No	0	8	3
361	R:R:F228	R:R:Q225	1.17	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N15	12.2125	4	4	7
2	R:R:V20	8.53	5	4	6
3	R:R:P23	9.08	4	2	5
4	R:R:F24	7.448	5	2	5
5	R:R:Q28	6.6525	4	2	5
6	R:R:Y29	9.1525	4	5	4
7	R:R:Y30	8.76	4	0	4
8	R:R:Q36	7.8675	4	6	2
9	R:R:F37	6.4625	4	5	5
10	R:R:N55	6.112	5	7	9
11	R:R:H65	6.696	5	8	5
12	R:R:L68	6.964	5	8	7
13	R:R:I75	5.215	4	3	7
14	R:R:N78	5.36667	6	3	9
15	R:R:D83	7.49	4	7	9
16	R:R:F91	6.958	5	0	7
17	R:R:F103	5.374	5	2	8
18	R:R:F105	5.4925	4	0	7
19	R:R:C110	5.2075	4	2	9
20	R:R:I123	4.52	4	0	7
21	R:R:W126	10.885	4	0	5
22	R:R:Y136	6.734	5	9	7
23	R:R:F148	6.29	5	0	7
24	R:R:P170	4.51	4	1	7
25	R:R:W175	8.436	5	1	5
26	R:R:R177	13.8275	4	1	5
27	R:R:P180	6.44	5	2	3
28	R:R:Q184	6.34	4	2	3
29	R:R:C187	6.4675	4	2	9
30	R:R:D190	10.416	5	1	4
31	R:R:Y191	6.53	6	1	6
32	R:R:Y192	7.198	5	1	5
33	R:R:T193	6.625	4	1	5
34	R:R:H195	15.67	4	1	4
35	R:R:T198	5.605	4	1	1
36	R:R:N200	5.875	4	1	4
37	R:R:F203	8.87	6	1	6
38	R:R:Y206	6.7725	4	1	4
39	R:R:M207	5.565	4	1	5
40	R:R:H211	8.91833	6	1	6
41	R:R:F212	5.4025	4	1	8
42	R:R:Y223	9.5025	4	0	9
43	R:R:E247	4.8425	4	0	7
44	R:R:F261	5.0175	4	1	9
45	R:R:Y268	11.928	5	1	6
46	R:R:F283	8.1875	4	0	4
47	R:R:P285	5.445	4	0	3
48	R:R:F313	9.755	4	0	8
49	L:L:?405	8.32636	11	1	0
50	H:H:?1	14.97	5	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P180	R:R:Q184	31.2391	6.32	Yes	Yes	2	3	3
2	R:R:C187	R:R:P180	60.3267	5.65	Yes	Yes	2	9	3
3	R:R:C187	R:R:E113	63.3531	4.56	Yes	No	2	9	5
4	R:R:E113	R:R:S186	94.7191	4.31	No	No	0	5	5
5	R:R:S186	R:R:T94	95.3334	6.4	No	No	0	5	7
6	R:R:M44	R:R:T94	99.4407	6.02	No	No	0	7	7
7	R:R:F91	R:R:M44	100	3.73	Yes	No	0	7	7
8	R:R:F91	R:R:K296	81.3369	8.69	Yes	No	0	7	7
9	L:L:?405	R:R:K296	80.8771	6.01	Yes	No	0	0	7
10	L:L:?405	R:R:Y191	36.3278	10	Yes	Yes	1	0	6
11	R:R:Y191	R:R:Y192	23.4293	10.92	Yes	Yes	1	6	5
12	R:R:Q28	R:R:Y30	42.4973	10.15	Yes	Yes	0	5	4
13	R:R:V20	R:R:Y30	28.5592	12.62	Yes	Yes	0	6	4
14	H:H:?1	R:R:V20	16.6833	5.35	Yes	Yes	4	0	6
15	R:R:P23	R:R:Q28	23.6112	4.74	Yes	Yes	2	5	5
16	H:H:?1	H:H:?2	11.9686	33.43	Yes	No	0	0	0
17	R:R:C110	R:R:F103	12.0406	4.19	Yes	Yes	2	9	8
18	R:R:F103	R:R:F105	28.7479	4.29	Yes	Yes	0	8	7
19	R:R:F105	R:R:V104	23.443	7.87	Yes	No	0	7	4
20	R:R:V104	R:R:Y102	20.8421	11.36	No	No	0	4	4
21	R:R:P27	R:R:Y102	19.5004	6.95	No	No	0	8	4
22	R:R:P27	R:R:Y29	18.1519	11.13	No	Yes	0	8	4
23	R:R:F37	R:R:Y29	14.0308	7.22	Yes	Yes	5	5	4
24	R:R:F91	R:R:L47	74.457	13.4	Yes	No	0	7	7
25	R:R:L47	R:R:T297	66.3041	4.42	No	No	1	7	6
26	R:R:F91	R:R:V87	12.624	5.24	Yes	No	0	7	6
27	R:R:I48	R:R:V87	11.3921	3.07	No	No	0	6	6
28	R:R:F91	R:R:M86	53.3404	3.73	Yes	No	0	7	7
29	R:R:A299	R:R:M86	49.3875	4.83	No	No	0	9	7
30	R:R:A299	R:R:D83	48.3821	4.63	No	Yes	0	9	9
31	R:R:D83	R:R:N55	41.7116	13.46	Yes	Yes	7	9	9
32	R:R:A80	R:R:N55	35.7822	3.13	No	Yes	0	9	9
33	R:R:A80	R:R:T58	34.6876	3.36	No	No	0	9	9
34	R:R:I307	R:R:T58	33.5861	12.16	No	No	0	7	9
35	R:R:F313	R:R:I307	31.3626	6.28	Yes	No	0	8	7
36	R:R:F313	R:R:L68	25.6837	14.61	Yes	Yes	0	8	7
37	R:R:H65	R:R:L68	16.1891	3.86	Yes	Yes	8	5	7
38	R:R:T297	R:R:Y301	68.2325	4.99	No	No	1	6	5
39	R:R:S298	R:R:Y301	61.912	6.36	No	No	1	9	5
40	R:R:N302	R:R:S298	76.3168	5.96	No	No	0	9	9
41	R:R:L128	R:R:N302	75.6168	4.12	No	No	0	8	9
42	R:R:L128	R:R:Y306	74.9099	16.41	No	No	0	8	9
43	R:R:M257	R:R:Y306	69.0286	11.97	No	No	0	8	9
44	R:R:M257	R:R:Y223	68.2531	13.17	No	Yes	0	8	9
45	R:R:R135	R:R:Y223	42.0307	9.26	No	Yes	0	9	9
46	R:R:L131	R:R:R135	41.0768	17.01	No	No	0	9	9
47	R:R:I75	R:R:L131	40.0954	4.28	Yes	No	0	7	9
48	R:R:I75	R:R:V130	18.8896	6.14	Yes	No	0	7	7
49	R:R:E134	R:R:V130	16.6181	5.7	No	No	0	8	7
50	R:R:E134	R:R:F148	15.472	12.83	No	Yes	0	8	7
51	R:R:I75	R:R:N78	19.9465	4.25	Yes	Yes	3	7	9
52	R:R:I123	R:R:N78	15.4754	4.25	Yes	Yes	0	7	9
53	R:R:I123	R:R:L119	12.0063	5.71	Yes	No	0	7	5
54	L:L:?405	R:R:M207	29.3072	7.24	Yes	Yes	1	0	5
55	R:R:H211	R:R:M207	20.4749	3.94	Yes	Yes	1	6	5
56	R:R:E122	R:R:H211	13.42	7.39	No	Yes	1	6	6
57	R:R:C264	R:R:W265	20.4989	10.45	No	No	1	8	8
58	R:R:L125	R:R:W265	14.844	14.81	No	No	1	7	8
59	R:R:E122	R:R:L125	18.8896	3.98	No	No	1	6	7
60	R:R:H211	R:R:W126	10.7745	9.52	Yes	Yes	0	6	5
61	R:R:A132	R:R:Y223	13.2073	8.01	No	Yes	0	9	9
62	R:R:C222	R:R:Y136	10.8671	6.72	No	Yes	0	8	7
63	R:R:A132	R:R:C222	12.0406	1.81	No	No	0	9	8
64	R:R:V254	R:R:Y223	21.1577	7.57	No	Yes	0	8	9
65	R:R:V227	R:R:V254	20.0357	4.81	No	No	0	5	8
66	R:R:K231	R:R:V227	18.9102	6.07	No	No	0	5	5
67	R:R:E247	R:R:K231	16.6386	10.8	Yes	No	0	7	5
68	L:L:?405	R:R:I189	10.2117	4.87	Yes	No	0	0	4
69	R:R:F203	R:R:M207	16.7382	6.22	Yes	Yes	1	6	5
70	R:R:F203	R:R:S176	13.5298	10.57	Yes	No	0	6	5
71	R:R:N200	R:R:S176	11.5088	4.47	Yes	No	0	4	5
72	R:R:M288	R:R:Y191	10.4313	5.99	No	Yes	1	4	6
73	R:R:F287	R:R:M288	10.071	3.73	No	No	0	4	4
74	R:R:P180	R:R:P23	27.6807	7.79	Yes	Yes	2	3	5
75	R:R:Q184	R:R:Q28	23.2303	6.4	Yes	Yes	2	3	5
76	R:R:E113	R:R:F103	30.7415	7	No	Yes	2	5	8
77	R:R:C110	R:R:F24	12.3494	5.59	Yes	Yes	2	9	5
78	R:R:C264	R:R:S298	15.0945	5.16	No	No	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F91	R:R:K296	8.69	0	Yes	No	7	7	2	1
R:R:T118	R:R:Y178	9.99	0	No	No	4	3	1	2
L:L:?405	R:R:T118	10.06	1	Yes	No	0	4	0	1
R:R:C167	R:R:M207	4.86	1	No	Yes	5	5	2	1
R:R:C167	R:R:H211	11.79	1	No	Yes	5	6	2	2
R:R:E181	R:R:Y268	4.49	0	No	Yes	4	6	2	1
L:L:?405	R:R:G188	5.84	1	Yes	No	0	5	0	1
R:R:F203	R:R:I189	6.28	1	Yes	No	6	4	2	1
L:L:?405	R:R:I189	4.87	1	Yes	No	0	4	0	1
R:R:Y191	R:R:Y192	10.92	1	Yes	Yes	6	5	1	2
R:R:Y191	R:R:Y268	5.96	1	Yes	Yes	6	6	1	1
R:R:V271	R:R:Y191	3.79	0	No	Yes	5	6	2	1
R:R:M288	R:R:Y191	5.99	1	No	Yes	4	6	2	1
L:L:?405	R:R:Y191	10	1	Yes	Yes	0	6	0	1
R:R:M288	R:R:Y192	8.38	1	No	Yes	4	5	2	2
R:R:F203	R:R:M207	6.22	1	Yes	Yes	6	5	2	1
R:R:H211	R:R:M207	3.94	1	Yes	Yes	6	5	2	1
L:L:?405	R:R:M207	7.24	1	Yes	Yes	0	5	0	1
R:R:F208	R:R:F212	5.36	1	No	Yes	5	8	2	1
R:R:F208	R:R:I213	6.28	1	No	No	5	4	2	2
R:R:F212	R:R:I213	3.77	1	Yes	No	8	4	1	2
R:R:A269	R:R:F212	8.32	0	No	Yes	7	8	2	1
L:L:?405	R:R:F212	4.16	1	Yes	Yes	0	8	0	1
R:R:P291	R:R:Y268	12.52	0	No	Yes	6	6	2	1
L:L:?405	R:R:Y268	34	1	Yes	Yes	0	6	0	1
L:L:?405	R:R:A272	4.03	1	Yes	No	0	5	0	1
L:L:?405	R:R:K296	6.01	1	Yes	No	0	7	0	1
R:R:A168	R:R:T118	3.36	0	No	No	7	4	2	1
L:L:?405	R:R:A117	2.69	1	Yes	No	0	5	0	1
L:L:?405	R:R:A295	2.69	1	Yes	No	0	8	0	1
R:R:A292	R:R:Y268	2.67	0	No	Yes	5	6	2	1
R:R:V204	R:R:Y191	2.52	0	No	Yes	4	6	2	1
R:R:A117	R:R:G90	1.95	0	No	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	4J4Q_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.73
Number of Linked Nodes	318
Number of Links	361
Number of Hubs	50
Number of Links mediated by Hubs	182
Number of Communities	10
Number of Nodes involved in Communities	74
Number of Links involved in Communities	102

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	67585
Length Of Smallest Path	3
Average Path Length	16.102
Length of Longest Path	37
Minimum Path Strength	1.47
Average Path Strength	7.1725
Maximum Path Strength	31
Minimum Path Correlation	0.71
Average Path Correlation	0.954049
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	59.8736
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.6327
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• guanyl nucleotide binding • binding • nucleotide binding • GDP binding • guanyl ribonucleotide binding • purine ribonucleotide binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • kinase binding • enzyme binding • protein kinase binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • acyl binding • GTP binding • purine ribonucleoside triphosphate binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • detection of light stimulus involved in visual perception • detection of light stimulus • response to light stimulus • multicellular organismal process • detection of external stimulus • sensory perception of light stimulus • system process • nervous system process • response to stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of light stimulus involved in sensory perception
Gene Ontology	Biological Process	• detection of light stimulus involved in visual perception • detection of light stimulus • response to light stimulus • multicellular organismal process • detection of external stimulus • sensory perception of light stimulus • system process • nervous system process • response to stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of light stimulus involved in sensory perception • response to abiotic stimulus • response to radiation • visual perception • detection of stimulus involved in sensory perception • phototransduction • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • detection of visible light • cell communication • cellular process • signal transduction • phototransduction, visible light • negative regulation of hydrolase activity • regulation of molecular function • regulation of catalytic activity • regulation of hydrolase activity • negative regulation of cyclic-nucleotide phosphodiesterase activity • negative regulation of molecular function • negative regulation of catalytic activity • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • membrane-bounded organelle • non-motile cilium • membrane • plasma membrane • cilium • 9+0 non-motile cilium • neuron projection • ciliary membrane • photoreceptor outer segment membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell periphery • cell projection • bounding membrane of organelle
Gene Ontology	Cellular Component	• membrane-bounded organelle • non-motile cilium • membrane • plasma membrane • cilium • 9+0 non-motile cilium • neuron projection • ciliary membrane • photoreceptor outer segment membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell periphery • cell projection • bounding membrane of organelle • cellular anatomical structure • photoreceptor cell cilium • organelle • plasma membrane region • organelle membrane • cell projection membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • photoreceptor disc membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • receptor complex • intracellular anatomical structure • cytoplasm • opsin binding • protein binding • binding • arrestin family protein binding • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • vitamin binding • retinal binding • isoprenoid binding • retinoid binding • lipid binding • 11-cis retinal binding • small molecule binding • G-protein alpha-subunit binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • cation binding • transition metal ion binding • zinc ion binding • ion binding • metal ion binding • identical protein binding • multicellular organismal process • rod bipolar cell differentiation • cellular developmental process • sensory organ development • retina development in camera-type eye • visual system development • neural retina development • neurogenesis • multicellular organism development • eye morphogenesis • neuron differentiation • cell differentiation • anatomical structure development • animal organ morphogenesis • sensory system development • system development • developmental process • camera-type eye morphogenesis • eye development • animal organ development • nervous system development • retinal bipolar neuron differentiation • glutamatergic neuron differentiation • generation of neurons • retina morphogenesis in camera-type eye • anatomical structure morphogenesis • sensory organ morphogenesis • camera-type eye development • cellular process • cellular response to stimulus • response to light stimulus • response to stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of cellular process • signaling • detection of abiotic stimulus • cell communication • signal transduction • detection of light stimulus • phototransduction • detection of external stimulus • regulation of biological process • biological regulation • detection of visible light • response to external stimulus • detection of stimulus • G protein-coupled receptor signaling pathway • G protein-coupled opsin signaling pathway • phototransduction, visible light • response to light intensity • podosome assembly • organelle assembly • protein-containing complex organization • membraneless organelle assembly • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • protein-containing complex assembly • cellular component organization or biogenesis • biosynthetic process • metabolic process • macromolecule metabolic process • gene expression • macromolecule biosynthetic process • multicellular organismal-level homeostasis • homeostatic process • anatomical structure homeostasis • tissue homeostasis • retina homeostasis • photoreceptor cell maintenance • absorption of visible light • light absorption • microtubule cytoskeleton organization • microtubule-based process • cytoskeleton organization • sensory perception of light stimulus • system process • sensory perception • nervous system process • visual perception • thermoception • sensory perception of temperature stimulus • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of temperature stimulus involved in thermoception • detection of temperature stimulus • detection of stimulus involved in sensory perception • taxis • thermotaxis • locomotion • cell-cell junction • anchoring junction • cell junction • sperm midpiece • 9+2 motile cilium • sperm flagellum • motile cilium • photoreceptor inner segment membrane • Golgi membrane • Golgi apparatus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • outer membrane • sperm head • sperm head plasma membrane • sperm plasma membrane • rod photoreceptor outer segment
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BOG
PDB Residues	L:L:?405
Environment Details	Open EMBL-EBI Page
Code	BOG
Name	octyl beta-D-glucopyranoside
Synonyms	Beta-Octylglucoside; octyl beta-D-glucoside; octyl D-glucoside; octyl glucoside
Identifier
Formula	C14 H28 O6
Molecular Weight	292.369
SMILES
PubChem	62852
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	5
Total Bonds	48
Total Aromatic Bonds	0


Code	NAG
PDB Residues	H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	BMA
PDB Residues	H:H:?3
Environment Details	Open EMBL-EBI Page
Code	BMA
Name	beta-D-mannopyranose
Synonyms	beta-D-mannose; D-mannose; mannose
Identifier
Formula	C6 H12 O6
Molecular Weight	180.156
SMILES
PubChem	439680
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	5
Total Bonds	24
Total Aromatic Bonds	0


Code	PLM
PDB Residues	H:H:?4
Environment Details	Open EMBL-EBI Page
Code	PLM
Name	Palmitic Acid
Synonyms	Palmitinsäure
Identifier
Formula	C16 H32 O2
Molecular Weight	256.424
SMILES
PubChem	985
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


Code	MAN
PDB Residues	H:H:?5
Environment Details	Open EMBL-EBI Page
Code	MAN
Name	alpha-D-mannopyranose
Synonyms	alpha-D-mannose; D-mannose; mannose
Identifier
Formula	C6 H12 O6
Molecular Weight	180.156
SMILES
PubChem	185698
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	5
Total Bonds	24
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P02699
Sequence	>4J4Q_nogp_Chain_R M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H K K L R T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G Y F V F G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K P M S N F R F G E N H A I M G V A F T W V M A L A C A A P P L V G W S R Y I P E G M Q C S C G I D Y Y T P H E E T N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q Q E S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H Q G S D F G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q F R N C M V T T L C C G K N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8P13	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.2	2024-11-20	To be published
	8P13 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.2	2024-11-20	To be published
	8P15	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.9	2024-11-20	To be published
	8P15 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.9	2024-11-20	To be published
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	doi.org/10.1073/pnas.1718084115
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol		2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol		2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PEL (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol		3.19	2020-06-24	To be published
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.6	2006-09-02	doi.org/10.1002/anie.200600595
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4J4Q (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-		2.65	2013-10-30	doi.org/10.1002/anie.201302374
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	doi.org/10.1016/j.bpj.2010.08.003
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	doi.org/10.1016/j.cell.2017.07.002
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	doi.org/10.1016/j.jmb.2004.07.044
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	doi.org/10.1016/j.jmb.2004.08.090
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	doi.org/10.1016/j.jmb.2007.03.007
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OY9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4X1H (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-		2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	doi.org/10.1021/bi0155091
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	doi.org/10.1038/embor.2013.44
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	4BEY (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	doi.org/10.1038/nature06925
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	doi.org/10.1038/nature07063
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3DQB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	3PQR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.85	2011-03-09	doi.org/10.1038/nature09789
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	3	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	2X72 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3	2011-03-16	doi.org/10.1038/nature09795
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	doi.org/10.1038/nature14656
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Arrestin1 Finger Loop	2.75	2014-09-17	doi.org/10.1038/ncomms5801
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	5WKT (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	9EPP	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPP (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/β1/γ2	4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	6CMO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-		4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	5.8	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	7	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4.1	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	doi.org/10.1038/sdata.2016.21
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.8	2006-08-22	doi.org/10.1073/pnas.0601765103
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	doi.org/10.1073/pnas.0608022103
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	doi.org/10.1073/pnas.082666399
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	4A4M (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	-	2.7	2017-03-15	doi.org/10.1073/pnas.1617446114
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	doi.org/10.1073/pnas.1617446114
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	doi.org/10.1073/pnas.1902192116
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	doi.org/10.1074/jbc.C800040200
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	doi.org/10.1074/jbc.RA119.010089
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	doi.org/10.1107/S0907444908017162
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	doi.org/10.1107/S0907444908017162
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Go	3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	6FUF (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	doi.org/10.1126/science.289.5480.739
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2015-06-17	doi.org/10.1371/journal.pone.0126970
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.3	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.81	2016-08-10	doi.org/10.15252/embr.201642671
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	doi.org/10.1529/biophysj.107.108225
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gi1/β1/γ1	4.38	2019-07-10	doi.org/10.7554/eLife.46041
	6QNO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.38	2019-07-10	doi.org/10.7554/eLife.46041
	9EPR	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-	Gi1/β1/γ2	4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-		4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6NWE (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		2.71	2020-02-12	To be published
	8P12	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	3.21	2024-11-20	To be published
	8P12 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.21	2024-11-20	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4J4Q_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.