Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N15 13.0375427
2R:R:V20 8.525626
3R:R:P23 9.0525425
4R:R:F24 6.108575
5R:R:Q28 8.315425
6R:R:Y29 7.76404
7R:R:Y30 8.15524
8R:R:L31 6.1025424
9R:R:M44 5.8125497
10R:R:N55 6.1225129
11R:R:Q64 12.67435
12R:R:H65 10.8425435
13R:R:K67 9.172535
14R:R:L68 4.988537
15R:R:N73 8.5438
16R:R:Y74 7.80254135
17R:R:F91 5.2575497
18R:R:F103 7.4478
19R:R:I123 5.454157
20R:R:W126 8.136515
21R:R:V129 5.4375407
22R:R:E134 11.2925488
23R:R:R135 9.394589
24R:R:Y136 9.4925407
25R:R:W161 6.474159
26R:R:P170 6.3775417
27R:R:P171 10.7775415
28R:R:L172 4.1475405
29R:R:W175 11.4575415
30R:R:R177 12.64455
31R:R:Y178 8.926503
32R:R:E181 8.3525444
33R:R:Q184 7.8425423
34R:R:D190 11.9175454
35R:R:Y191 5.0325406
36R:R:Y192 8.22445
37R:R:H195 16.46454
38R:R:N200 8.5325454
39R:R:F203 11.92616
40R:R:Y206 6.862514
41R:R:M207 8.5125415
42R:R:H211 8.044516
43R:R:V230 7.33468
44R:R:Q244 6.244564
45R:R:K245 10.1575464
46R:R:M253 6.095148
47R:R:M257 6.82754148
48R:R:W265 7.995608
49R:R:F283 5.58544
50R:R:F287 6.3875444
51R:R:M288 7.8475444
52R:R:F293 7.125695
53R:R:K296 6.3375497
54R:R:Y301 7.8675405
55R:R:Y306 14.304509
56R:R:N310 5.9925408
57R:R:Q312 8.228536
58R:R:F313 10408
59R:R:E332 5.21535
60R:R:E341 7.085405
61L:L:?8 8.205600
62H:H:?6 21.9875420
63H:H:?9 15.6425100
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M288 R:R:V271 16.70547.61YesNo045
2R:R:M288 R:R:Y268 17.53018.38YesNo446
3R:R:Y191 R:R:Y268 21.63314.96YesNo066
4R:R:I189 R:R:Y191 24.64726.04NoYes046
5R:R:I189 R:R:Y178 25.58857.25NoYes043
6R:R:G114 R:R:Y178 25.41395.79NoYes053
7R:R:E113 R:R:G114 24.96044.91NoNo055
8R:R:C187 R:R:E113 44.20577.6NoNo095
9R:R:C187 R:R:F103 42.45456.98NoYes798
10R:R:F103 R:R:F24 39.95975.36YesYes785
11R:R:F24 R:R:S22 36.48763.96YesNo055
12R:R:F9 R:R:S22 34.74477.93NoNo075
13R:R:F9 R:R:P23 32.121513NoYes075
14R:R:P23 R:R:Q28 16.13316.32YesYes255
15R:R:Q28 R:R:Y30 12.657611.27YesYes254
16R:R:P180 R:R:P23 11.78915.84NoYes235
17R:R:I179 R:R:P180 11.03715.08NoNo013
18R:R:D190 R:R:I179 10.123412.59YesNo041
19R:R:I286 R:R:I290 10.00682.94NoNo015
20R:R:I290 R:R:P291 10.4715.08NoNo056
21R:R:P291 R:R:V271 10.9348.84NoNo065
22R:R:T118 R:R:Y178 51.79839.99NoYes043
23L:L:?8 R:R:T118 52.45578.81YesNo004
24L:L:?8 R:R:K296 25.62068.43YesYes007
25R:R:E113 R:R:T94 20.31617.06NoNo057
26R:R:M44 R:R:T94 20.6447.53YesNo077
27R:R:K296 R:R:M44 20.72225.76YesYes977
28L:L:?8 R:R:W265 88.13214.54YesYes008
29R:R:C264 R:R:W265 50.16710.45NoYes088
30R:R:C264 R:R:Y301 50.22339.41NoYes085
31R:R:N302 R:R:Y301 10011.63NoYes095
32R:R:M257 R:R:N302 99.73754.21YesNo089
33R:R:L76 R:R:M257 39.06075.65NoYes088
34R:R:L76 R:R:Y306 38.842125.79NoYes089
35R:R:N73 R:R:Y306 33.44074.65YesYes089
36R:R:L68 R:R:N73 22.32995.49YesYes378
37R:R:H65 R:R:L68 16.83055.14YesYes357
38R:R:H65 R:R:Q64 10.155516.07YesYes355
39R:R:Q64 R:R:Y60 17.31775.64YesNo053
40R:R:F56 R:R:Y60 15.99235.16NoNo043
41R:R:F52 R:R:F56 14.66584.29NoNo064
42R:R:F52 R:R:F88 12.009313.93NoNo064
43R:R:F88 R:R:V87 10.67946.55NoNo046
44R:R:S298 R:R:W265 50.00824.94NoYes098
45R:R:S298 R:R:Y301 50.03635.09NoYes095
46R:R:M253 R:R:M257 60.28934.33YesYes1488
47R:R:M253 R:R:Y306 40.34665.99YesYes089
48R:R:F313 R:R:Y306 36.858825.79YesYes089
49R:R:F313 R:R:V61 11.38076.55YesNo087
50R:R:T320 R:R:V61 10.71437.93NoNo057
51R:R:F313 R:R:T58 16.71333.89YesNo089
52R:R:K67 R:R:V337 13.954313.66YesNo055
53R:R:S343 R:R:V337 11.63136.46NoNo095
54R:R:K67 R:R:Q312 13.151113.56YesYes356
55R:R:N310 R:R:Y306 12.09619.3YesYes089
56R:R:N310 R:R:Q312 15.70627.92YesYes086
57R:R:L72 R:R:M253 20.71665.65NoYes088
58R:R:L72 R:R:V250 17.22545.96NoNo088
59R:R:R135 R:R:V250 16.49256.54YesNo898
60R:R:H211 R:R:W126 10.07334.23YesYes165
61L:L:?8 R:R:E122 13.103817.6YesNo006
62R:R:E122 R:R:H211 11.44717.39NoYes166
63R:R:F261 R:R:W265 13.905320.04NoYes098
64R:R:R135 R:R:T251 12.048211.64YesNo096
65R:R:T251 R:R:V230 11.66293.17NoYes068
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 4.98 9 Yes Yes 7 7 2 2
R:R:F293 R:R:M44 4.98 9 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 5.76 9 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 4.96 9 Yes Yes 7 7 2 1
L:L:?8 R:R:A117 4.19 0 Yes No 0 5 0 1
R:R:T118 R:R:Y178 9.99 0 No Yes 4 3 1 2
L:L:?8 R:R:T118 8.81 0 Yes No 0 4 0 1
R:R:C167 R:R:E122 12.15 1 No No 5 6 2 1
R:R:E122 R:R:H211 7.39 1 No Yes 6 6 1 2
L:L:?8 R:R:E122 17.6 0 Yes No 0 6 0 1
R:R:C167 R:R:H211 11.79 1 No Yes 5 6 2 2
R:R:F212 R:R:L216 12.18 0 No No 8 7 1 2
L:L:?8 R:R:F212 5.66 0 Yes No 0 8 0 1
R:R:F261 R:R:W265 20.04 0 No Yes 9 8 2 1
R:R:C264 R:R:W265 10.45 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 5.19 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 4.94 0 No Yes 9 8 2 1
L:L:?8 R:R:W265 4.54 0 Yes Yes 0 8 0 1
R:R:F293 R:R:K296 6.2 9 Yes Yes 5 7 2 1
L:L:?8 R:R:K296 8.43 0 Yes Yes 0 7 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
R:R:G121 R:R:W265 2.81 0 No Yes 7 8 2 1
R:R:A269 R:R:F212 2.77 0 No No 7 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
75.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
75.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
75.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
66.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
66.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
66.67Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
66.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
66.67Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
66.67Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
66.67Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
66.67Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
62.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
62.50Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
60.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
60.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
60.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
60.00Consensussensory_offOrthosteric Ligandopsin_off
55.56Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
55.56Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
55.56Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
55.56Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
50.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
50.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
50.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
50.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
46.15Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
44.44Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
44.44Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
44.44Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
44.44Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
44.44Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
44.44Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
44.44Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
41.67Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
41.67Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
41.67Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
41.67Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
41.67Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
41.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
40.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
40.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
40.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
40.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
40.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
40.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
40.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
38.46Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
38.46Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
38.46Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
38.46Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
38.46Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
37.50Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
37.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
36.36Single6B73PubChem 1319551386B73-κ-PubChem 131955138
36.36Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
36.36Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
36.36Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
36.36Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
36.36Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
36.36Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
36.36Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
36.36Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
36.36Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
36.36Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
36.36Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
36.36Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
36.36Consensusalpha1_onOrthosteric Ligandalpha1a_on
36.36Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
36.36Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Consensusgt_class-aOrthosteric Ligandgt_opsin
36.36Consensusgt_opsinOrthosteric Ligandgt_sensory
36.36Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
36.36Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
36.36Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
35.71Single4U15Tiotropium4U15-M3-Tiotropium
35.71Single5V54Methiothepin5V54-5-HT1B-Methiothepin
35.71Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
35.71Single6OL9Tiotropium6OL9-M5-Tiotropium
35.71Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
35.71Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.71Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
35.71Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
35.71Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
35.71Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
35.71Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Consensus5ht1_offOrthosteric Ligand5ht1b_off
35.71Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
35.71Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
35.71Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
35.71Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
33.33Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
33.33Single3RZECidoxepin3RZE-H1-Cidoxepin
33.33Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
33.33Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
33.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
33.33Single5CXVTiotropium5CXV-M1-Tiotropium
33.33Single6CM4Risperidone6CM4-D2-Risperidone
33.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
33.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
33.33Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
33.33Single6ZG4HTL00099366ZG4-M1-HTL0009936
33.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
33.33Single7DFPSpiperone7DFP-D2-Spiperone
33.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
33.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
33.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
33.33Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
33.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
33.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
33.33Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
33.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
33.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
33.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
33.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
33.33Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
33.33Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
33.33Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
33.33Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
33.33Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
33.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
33.33Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
33.33Consensussensory_onOrthosteric Ligandopsin_on
31.25Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
31.25Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
31.25Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
31.25Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
31.25Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
31.25Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
31.25Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
30.77Single3NY8ICI 118-5513NY8-β2-ICI 118-551
30.77Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
30.77Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
30.77Single4EJ4Naltrindole4EJ4-δ-Naltrindole
30.77Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
30.77Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
30.77Single4MQSIperoxo4MQS-M2-Iperoxo
30.77Single4U14Tiotropium4U14-M3-Tiotropium
30.77Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
30.77Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
30.77Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
30.77Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
30.77Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
30.77Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
30.77Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
30.77Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
30.77Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.77Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
30.77Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
30.77Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
30.77Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
30.77Single8JJOAlprenolol8JJO-β2-Alprenolol
30.77Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
30.77Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
30.77Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
30.77Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
30.77Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8X64Desloratadine8X64-H1-Desloratadine
30.77Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
30.77Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
30.77Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
30.77Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
30.77Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
30.77Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
30.77Consensusblt_onOrthosteric Ligandblt1_on
30.77Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
30.77Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
30.77Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
30.77Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
30.77Consensushistamine_onOrthosteric Ligandh1_on h4_on
30.77Consensusleuko_onOrthosteric Ligandblt_on
30.77Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
30.77Consensustar_onOrthosteric Ligandta1_on
30.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
30.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
30.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
30.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
30.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single7SK9CCX6627SK9-ACKR3-CCX662
29.41Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
28.57Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
28.57Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
28.57Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
28.57Single6LUQHaloperidol6LUQ-D2-Haloperidol
28.57Single6PS6Timolol6PS6-β2-Timolol
28.57Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
28.57Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
28.57Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
28.57Single8EA0Iperoxo8EA0-M3-Iperoxo
28.57Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
28.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
28.57Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
28.57Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
28.57Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
28.57Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
28.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
28.57Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
28.57Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
27.27Single3PBLEticlopride3PBL-D3-Eticlopride
27.27Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
27.27Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
27.27Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
27.27Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
27.27Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
27.27Single7SRQLSD7SRQ-5-HT2B-LSD
27.27Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
27.27Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.27Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
27.27Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
27.27Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
27.27Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.67Single2YDVNECA2YDV-A2A-NECA
26.67Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
26.67Single4DJHJDTic4DJH-κ-JDTic
26.67Single4UHRCGS216804UHR-A2A-CGS21680
26.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
26.67Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
26.67Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
26.67Single5G53NECA5G53-A2A-NECA-Gs
26.67Single5X93K-87945X93-ETB-K-8794
26.67Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
26.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.67Single6J21Aprepitant6J21-NK1-Aprepitant
26.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
26.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.67Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
26.67Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
26.67Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
26.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
26.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
26.67Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
26.67Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
26.67Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
26.67Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
26.67Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
26.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.67Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
26.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
26.67Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
26.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
26.67Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
26.67Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
26.67Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
26.67Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.67Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
26.67Consensushistamine_offOrthosteric Ligandh1_off
26.67Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
26.67Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
26.67Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
26.67Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
26.67Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.67Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
26.32Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.32Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single4AMIBucindolol4AMI-β1-Bucindolol
25.00Single5DHHSB-6121115DHH-NOP-SB-612111
25.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single5WF5UK-4320975WF5-A2A-UK-432097
25.00Single6A93Risperidone6A93-5-HT2A-Risperidone
25.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
25.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.00Single6HLPNetupitant6HLP-NK1-Netupitant
25.00Single6KUXRS-799486KUX-α2a-RS-79948
25.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
25.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
25.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
25.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
25.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
25.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00Single7YITNalfurafine7YIT-κ-Nalfurafine
25.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
25.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGVEpinephrine8GGV-β2-Epinephrine
25.00Single8GGWEpinephrine8GGW-β2-Epinephrine
25.00Single8GGXEpinephrine8GGX-β2-Epinephrine
25.00Single8GH0Epinephrine8GH0-β2-Epinephrine
25.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IWESpermidine8IWE-TAAR9-Spermidine
25.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
25.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
25.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
25.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
25.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
25.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
25.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
25.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
23.81Single7C61Ergotamine7C61-5-HT1B-Ergotamine
23.53Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
23.53Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
23.53Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
23.53Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
23.53Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
23.53Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
23.53Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
23.53Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
23.53Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
23.53Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
23.53Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
23.53Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
23.53Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
23.53Consensusendothelin_offOrthosteric Ligandetb_off
23.53Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
23.08Single2YDOAdenosine2YDO-A2A-Adenosine
23.08Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
23.08Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
23.08Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
23.08Single6A94Zotepine6A94-5-HT2A-Zotepine
23.08Single6DS0Ly2660976DS0-5-HT2B-Ly266097
23.08Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
23.08Single6IQLL7458706IQL-D4-L745870
23.08Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
23.08Single6PS4ICI 118-5516PS4-β2-ICI 118-551
23.08Single6TPNHTL66416TPN-OX2-HTL6641
23.08Single6VI4JDTic6VI4-κ-JDTic
23.08Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
23.08Single6ZG9GSK10347026ZG9-M1-GSK1034702
23.08Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.08Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.08Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
23.08Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
23.08Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Single7VODCariprazine7VOD-5-HT2A-Cariprazine
23.08Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
23.08Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
23.08Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.08Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8GGIEpinephrine8GGI-β2-Epinephrine
23.08Single8GGQEpinephrine8GGQ-β2-Epinephrine
23.08Single8GGTEpinephrine8GGT-β2-Epinephrine
23.08Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
23.08Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Consensus5ht5_onOrthosteric Ligand5ht5a_on
23.08Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
23.08Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
23.08Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.08Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.08Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
22.73Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
22.22Single3NY9PubChem 9131033NY9-β2-PubChem 913103
22.22Single4UG2CGS216804UG2-A2A-CGS21680
22.22Single6PT3DPI-2876PT3-δ-DPI-287
22.22Single7WC4Serotonin7WC4-5-HT2A-Serotonin
22.22Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
22.22Single8X5YAstemizole8X5Y-H1-Astemizole
21.43Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
21.43Single2Y01Dobutamine2Y01-β1-Dobutamine
21.43Single2Y04Salbutamol2Y04-β1-Salbutamol
21.43Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
21.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
21.43Single4DAJTiotropium4DAJ-M3-Tiotropium
21.43Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
21.43Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
21.43Single4YAYZD-71554YAY-AT1-ZD-7155
21.43Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
21.43Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
21.43Single5DSGTiotropium5DSG-M4-Tiotropium
21.43Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
21.43Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
21.43Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
21.43Single5TGZAM65385TGZ-CB1-AM6538
21.43Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.43Single6DRXLisuride6DRX-5-HT2B-Lisuride
21.43Single6GPSMK08126GPS-CCR2-MK0812
21.43Single6H7MSalbutamol6H7M-β1-Salbutamol
21.43Single6IIVDaltroban6IIV-TP-Daltroban
21.43Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
21.43Single6PS1Timolol6PS1-β2-Timolol
21.43Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
21.43Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
21.43Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
21.43Single7BU7BI1671077BU7-β1-BI167107
21.43Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
21.43Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
21.43Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
21.43Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
21.43Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
21.43Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
21.43Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
21.43Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
21.43Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
21.43Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
21.43Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
21.43Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
21.43Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
21.43Single7WC7Lisuride7WC7-5-HT2A-Lisuride
21.43Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
21.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
21.43Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
21.43Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
21.43Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
21.43Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GGJEpinephrine8GGJ-β2-Epinephrine
21.43Single8GGNEpinephrine8GGN-β2-Epinephrine
21.43Single8GGOEpinephrine8GGO-β2-Epinephrine
21.43Single8GGUEpinephrine8GGU-β2-Epinephrine
21.43Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
21.43Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
21.43Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
21.43Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
21.43Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8X63Mepyramine8X63-H1-Mepyramine
21.43Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
21.43Consensusadenosine_onOrthosteric Liganda1_on a2_on
21.43Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
21.43Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
21.43Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
21.43Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
21.43Consensusgi_hcarOrthosteric Ligandgi_hca
21.43Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.43Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
21.43Consensusnucleotide_onOrthosteric Ligandadenosine_on
21.43Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
21.43Consensustachykinin_offOrthosteric Ligandnk1_off
21.43Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
21.05Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
21.05Single4IARErgotamine4IAR-5-HT1B-Ergotamine
21.05Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
21.05Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
21.05Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
21.05Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
21.05Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
21.05Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
20.83Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
20.00Single2Y00Dobutamine2Y00-β1-Dobutamine
20.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
20.00Single3QAKUK-4320973QAK-A2A-UK-432097
20.00Single5C1MBU725C1M-μ-BU72
20.00Single5CGCHTL142425CGC-mGlu5-HTL14242
20.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
20.00Single5WIUNemonapride5WIU-D4-Nemonapride
20.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
20.00Single5XPRBosentan5XPR-ETB-Bosentan
20.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6HLOAprepitant6HLO-NK1-Aprepitant
20.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
20.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
20.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
20.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
20.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
20.00Single7C4SS1P7C4S-S1P3-S1P
20.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
20.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
20.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
20.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7WC6LSD7WC6-5-HT2A-LSD
20.00Single7XKAEpinephrine7XKA-β2-Epinephrine
20.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
20.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
20.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
20.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
20.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
20.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Single8QOTNanobody E8QOT-μ-Nanobody E
20.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
20.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
20.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
20.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
20.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
20.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
20.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
20.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
20.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
20.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
20.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
20.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
20.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
19.05Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
19.05Single6PT2KGCHM076PT2-δ-KGCHM07
18.75Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
18.75Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
18.75Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
18.75Single4RWADIPP-NH24RWA-δ-DIPP-NH2
18.75Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
18.75Single6E59L-7607356E59-NK1-L-760735
18.75Single6H7JIsoprenaline6H7J-β1-Isoprenaline
18.75Single6J20Aprepitant6J20-NK1-Aprepitant
18.75Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
18.75Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
18.75Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
18.75Single7EPENAM5637EPE-mGlu-NAM563
18.75Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
18.75Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
18.75Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
18.75Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
18.75Single8E0GBU728E0G-μ-BU72
18.75Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
18.75Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
18.75Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
18.75Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
18.75Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
18.75Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
18.75Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
18.75Consensusa2_onOrthosteric Liganda2a_on a2b_on
18.75Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
18.75Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
18.75Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
18.75Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
18.75Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.18Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
18.18Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
18.18Single7WC5Psilocin7WC5-5-HT2A-Psilocin
18.18Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single8GGREpinephrine8GGR-β2-Epinephrine
18.18Single8GGZEpinephrine8GGZ-β2-Epinephrine
18.18Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
18.18Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
18.18Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
17.65Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
17.65Single4LDEBI1671074LDE-β2-BI167107
17.65Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.65Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
17.65Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
17.65Single5X33BIIL2605X33-BLT1-BIIL260
17.65Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.65Single6IIURamatroban6IIU-TP-Ramatroban
17.65Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
17.65Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.65Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.65Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.65Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
17.65Single7K15MKD0467K15-BLT1-MKD046-Na
17.65Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
17.65Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
17.65Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
17.65Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
17.65Single8JJ8Formoterol8JJ8-β2-Formoterol
17.65Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
17.65Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
17.65Consensusblt_offOrthosteric Ligandblt1_off
17.65Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
17.65Consensusgi_class-fOther Ligandgi_frizzled
17.65Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
17.65Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
17.65Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
17.65Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
17.65Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
17.65Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
16.67Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
16.67Single5CGDHTL142425CGD-mGlu5-HTL14242
16.67Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
16.67Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
16.67Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6H7LDobutamine6H7L-β1-Dobutamine
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single6IBLArformoterol6IBL-β1-Arformoterol
16.67Single6K1QIRL25006K1Q-ETB-IRL2500
16.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
16.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
16.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
16.67Single7EZCUKA7EZC-A2A-UKA
16.67Single7UM4AS26747237UM4-5-HT5A-AS2674723
16.67Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
16.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
16.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
16.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
16.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
16.67Single8GGSEpinephrine8GGS-β2-Epinephrine
16.67Single8GGYEpinephrine8GGY-β2-Epinephrine
16.67Single8GH1Epinephrine8GH1-β2-Epinephrine
16.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
16.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
16.67Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
16.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
16.67Single8K5BNiacin8K5B-HCA2-Niacin
16.67Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
16.67Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
16.67Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
16.67Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
16.67Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Consensusgo_class-b2Orthosteric Ligandgo_adhesion
16.67Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
16.67Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
16.67Consensussteroid_onOrthosteric Ligandbileacid_on
16.00Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.79Single5ZTYAM102575ZTY-CB2-AM10257
15.79Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.79Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
15.79Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
15.79Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
15.79Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
15.79Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.79Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.79Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
15.79Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
15.79Consensuslpl_offOrthosteric Ligands1p_off lpa_off
15.38Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.38Single5WS3EMPA5WS3-OX2-EMPA
15.38Single6AKXA4R6AKX-CCR5-A4R
15.38Single6AKYMaraviroc6AKY-CCR5-Maraviroc
15.38Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
15.38Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.38Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.38Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
15.38Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single6TODEMPA6TOD-OX1-EMPA-Na
15.38Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.38Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.38Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.38Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
15.38Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.38Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
15.38Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
15.38Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.38Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.38Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.38Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
15.38Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
15.38Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.38Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
15.38Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8IHKAcifran8IHK-HCA3-Acifran
15.38Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.38Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.38Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
15.38Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
15.38Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.38Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
15.38Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.38Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.00Single7QA8Peptide7QA8-STE2-Peptide
15.00Single7QA8Peptide7QA8-STE2-Peptide
15.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
15.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
15.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
15.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.00Consensusclass-d_offOrthosteric Ligandste2_off
15.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
15.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
15.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
14.81Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.81Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.81Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
14.29Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
14.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.29Single4ZJCSB-6740424ZJC-OX1-SB-674042
14.29Single6FFIMMPEP6FFI-mGlu5-MMPEP
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
14.29Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
14.29Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
14.29Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
14.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
14.29Single6TPGEMPA6TPG-OX2-EMPA
14.29Single6TPKRetosiban6TPK-OT-Retosiban
14.29Single6V9SGTPL114036V9S-OX1-GTPL11403
14.29Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
14.29Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
14.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
14.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
14.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
14.29Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
14.29Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
14.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single7T32ZM2413857T32-A2A-ZM241385
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGKEpinephrine8GGK-β2-Epinephrine
14.29Single8GGLEpinephrine8GGL-β2-Epinephrine
14.29Single8GGMEpinephrine8GGM-β2-Epinephrine
14.29Single8GGPEpinephrine8GGP-β2-Epinephrine
14.29Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
14.29Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
14.29Single8IYXYL-3658IYX-GPR34-YL-365
14.29Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
14.29Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
14.29Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
14.29Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
14.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
14.29Single8K5CAcipimox8K5C-HCA2-Acipimox
14.29Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
14.29Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
14.29Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
14.29Consensushca_onOrthosteric Ligandhca2_on hca3_on
14.29Consensushcar_onOrthosteric Ligandhca_on
14.29Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
14.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.29Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
14.29Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
14.29Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
14.29Consensuss1p_offOrthosteric Ligands1p1_off
14.29Consensusvasopressin-ot_offOrthosteric Ligandot_off
13.64Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
13.64Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
13.64Consensusangiotensin_onOrthosteric Ligandat1_on
13.64Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
13.64Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.64Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
13.64Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
13.33Single2Y02Carmoterol2Y02-β1-Carmoterol
13.33Single6FFHFenobam6FFH-mGlu5-Fenobam
13.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.33Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.33Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
13.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
13.33Single6TOTLemborexant6TOT-OX1-Lemborexant
13.33Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
13.33Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
13.33Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
13.33Single7UL4Alvimopan7UL4-μ-Alvimopan
13.33Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
13.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
13.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
13.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
13.33Single8CU6LJ-45178CU6-A2A-LJ-4517
13.33Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
13.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
13.33Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
13.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
13.33Single8K5DGSK2560738K5D-HCA2-GSK256073
13.33Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
13.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
13.33Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
13.33Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
13.33Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
13.33Consensushcar_offOrthosteric Ligandsuccinate_off
13.33Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
13.33Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
13.33Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.04Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
13.04Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.04Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
13.04Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensusclass-d_onOrthosteric Ligandste2_on
13.04Consensusgi_class-dOrthosteric Ligandgi_ste
13.04Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
13.04Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.04Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
13.04Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
12.50Single4NTJAZD12834NTJ-P2Y12-AZD1283
12.50Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
12.50Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
12.50Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
12.50Single5N2SPSB365N2S-A1-PSB36
12.50Single5NM2ZM2413855NM2-A2A-ZM241385-Na
12.50Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
12.50Single5TVNLSD5TVN-5-HT2B-LSD
12.50Single5WQCEMPA5WQC-OX2-EMPA
12.50Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
12.50Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
12.50Single6D26Fevipiprant6D26-DP2-Fevipiprant
12.50Single6E67BI1671076E67-β2-BI167107-Gs (fused)
12.50Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
12.50Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
12.50Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
12.50Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
12.50Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
12.50Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
12.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
12.50Single6TP6Filorexant6TP6-OX1-Filorexant
12.50Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
12.50Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
12.50Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
12.50Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
12.50Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
12.50Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
12.50Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
12.50Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.50Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
12.50Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.50Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
12.50Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
12.50Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
12.50Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
12.50Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
12.50Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.50Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
12.50Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
12.50Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
12.50Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
12.50Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
12.50Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
12.50Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
12.50Consensusep_offOrthosteric Ligandep4_off
12.50Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
12.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
12.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusclass-d_onOrthosteric Ligandste2_on
12.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
12.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
11.76Single3P0GBI1671073P0G-β2-BI167107
11.76Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
11.76Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
11.76Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
11.76Single5TZR-5TZR-FFA1 (GPR40)-MK8666
11.76Single5XR8AM8415XR8-CB1-AM841
11.76Single5XRAAM115425XRA-CB1-AM11542
11.76Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
11.76Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
11.76Single6WGTLSD6WGT-5-HT2A-LSD
11.76Single7B6WCyclazosin7B6W-α1b-Cyclazosin
11.76Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
11.76Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
11.76Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
11.76Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
11.76Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
11.76Single7P2L4YI7P2L-mGlu5-4YI
11.76Single7TUYGSK682753A7TUY-GPR183-GSK682753A
11.76Single7W41PD1762527W41-BB2-PD176252
11.76Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
11.76Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
11.76Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
11.76Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
11.76Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
11.76Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
11.76Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
11.76Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
11.76Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
11.76Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
11.76Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
11.76Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
11.76Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.76Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
11.76Consensus5ht5_offOrthosteric Ligand5ht5a_off
11.76Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusadenosine_offOrthosteric Liganda1_off a2_off
11.76Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
11.76Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
11.76Consensusbombesin_offOrthosteric Ligandbb2_off
11.76Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
11.76Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.76Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
11.76Consensuslpa_offOrthosteric Ligandlpa1_off
11.76Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
11.76Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
11.54Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
11.54Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.54Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
11.54Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
11.54Consensusendothelin_onOrthosteric Ligandetb_on eta_on
11.54Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
11.54Consensusgi_class-dOrthosteric Ligandgi_ste
11.54Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.54Consensusgo_class-b1Orthosteric Ligandgo_crf
11.54Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.11Single4N4WSANT-14N4W-SMO-SANT-1
11.11Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
11.11Single6IGLIRL16206IGL-ETB-IRL1620
11.11Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
11.11Single6LMLGlucagon6LML-Glucagon-Glucagon
11.11Single6MXTSalmeterol6MXT-β2-Salmeterol
11.11Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
11.11Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.11Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
11.11Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
11.11Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
11.11Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
11.11Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
11.11Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
11.11Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
11.11Single8IY6Endothelin-18IY6-ETB-Endothelin-1
11.11Single8JJLOlodaterol8JJL-β2-Olodaterol
11.11Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
11.11Single8JWZAB9288JWZ-A2A-AB928-Na
11.11Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.11Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8WU1KCA8WU1-CB1-KCA-Arrestin1
11.11Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
11.11Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
11.11Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
11.11Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
11.11Consensusclass-b2_onOrthosteric Ligandadgrg_on
11.11Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
11.11Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
11.11Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
11.11Consensusdp_offOrthosteric Liganddp2_off
11.11Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
11.11Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
11.11Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.11Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
11.11Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
11.11Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_steroidOrthosteric Ligandgs_bileacid
11.11Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
10.71Single5GLHEndothelin-15GLH-ETB-Endothelin-1
10.71Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.71Single6IGKEndothelin-36IGK-ETB-Endothelin-3
10.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
10.71Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.71Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
10.53Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
10.53Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
10.53Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
10.53Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
10.53Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
10.53Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
10.53Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
10.53Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
10.53Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
10.53Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
10.53Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
10.53Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
10.53Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
10.53Consensuscyslt_offOrthosteric Ligandcyslt2_off
10.53Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.53Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
10.53Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Consensusorexin_onOrthosteric Ligandox2_on
10.34Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.34Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.34Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
10.34Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
10.34Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
10.00Single5WF6UK-4320975WF6-A2A-UK-432097
10.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
10.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
10.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
10.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
10.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7XN9L-054,5227XN9-SST2-L-054,522
10.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
10.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
10.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
10.00Consensusclass-c_onOther Ligandgabab_on mglu_on
10.00Consensusclass-d_offOrthosteric Ligandste2_off
10.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
10.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
10.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
9.68Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
9.68Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
9.68Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
9.52Single4XT1Fractalkine4XT1-US28-Fractalkine
9.52Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
9.52Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
9.52Single7F8XNN90567F8X-CCKA-NN9056
9.52Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
9.52Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
9.52Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
9.52Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
9.52Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
9.52Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
9.52Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
9.52Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
9.38Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
9.38Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
9.38Consensuspth_onOrthosteric Ligandpth1_on pth2_on
9.09Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
9.09Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
9.09Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.09Single7SHEPI; PE7SHE-GPR158-PI; PE
9.09Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
9.09Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
9.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
9.09Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
9.09Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
8.82Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
8.82Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.70Single3OE0CVX153OE0-CXCR4-CVX15
8.70Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
8.70Single6W25SHU91196W25-MC4-SHU9119-Ca
8.70Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
8.70Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
8.70Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
8.70Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
8.70Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
8.70Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
8.70Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
8.33Single3OE6IT1t3OE6-CXCR4-IT1t
8.33Single3OE8IT1t3OE8-CXCR4-IT1t
8.33Single3UZAGTPL92363UZA-A2A-GTPL9236
8.33Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
8.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
8.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
8.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
8.33Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
8.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
8.33Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
8.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
8.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
8.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
8.33Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
8.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
8.33Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.33Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
8.11Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
8.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
8.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
8.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
8.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
8.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
8.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
8.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
8.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
8.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
7.69Single3OE9IT1t3OE9-CXCR4-IT1t
7.69Single4XT3Fractalkine4XT3-US28-Fractalkine
7.69Single5L7IVismodegib5L7I-SMO-Vismodegib
7.69Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.69Single6TP4ACT-4622066TP4-OX1-ACT-462206
7.69Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
7.69Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.69Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
7.69Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
7.69Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
7.69Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
7.69Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
7.69Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
7.69Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
7.69Consensusclass-t_onOrthosteric Ligandtaste2_on
7.69Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.69Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
7.69Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
7.69Consensusgs_class-tOrthosteric Ligandgs_taste
7.69Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
7.69Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
7.69Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
7.41Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
7.41Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
7.41Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
7.41Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
7.41Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
7.41Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
7.41Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
7.41Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
7.41Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
7.41Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.14Single3ODUIT1t3ODU-CXCR4-IT1t
7.14Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
7.14Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
7.14Single4K5YCP-3763954K5Y-CRF1-CP-376395
7.14Single5U09Taranabant5U09-CB1-Taranabant
7.14Single5ZKQABT-4915ZKQ-PAF-ABT-491
7.14Single6ME2Ramelteon6ME2-MT1-Ramelteon
7.14Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
7.14Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
7.14Single7BR3Elagolix7BR3-GnRH1-Elagolix
7.14Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
7.14Single7F8ULintitript7F8U-CCKA-Lintitript
7.14Single7F8YDevazepide7F8Y-CCKA-Devazepide
7.14Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
7.14Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
7.14Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
7.14Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
7.14Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
7.14Single7XRRLemborexant7XRR-OX2-Lemborexant
7.14Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
7.14Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
7.14Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
7.14Single8GNGIstradefylline8GNG-A2A-Istradefylline
7.14Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
7.14Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
7.14Single8HNNSCH5467388HNN-CXCR3-SCH546738
7.14Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
7.14Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
7.14Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
7.14Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
7.14Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
7.14Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
7.14Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
7.14Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
7.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
7.14Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
7.14Consensusorexin_offOrthosteric Ligandox2_off ox1_off
7.14Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
7.14Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
7.14Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
7.14Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.14Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.90Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
6.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
6.67Single5JTBZM2413855JTB-A2A-ZM241385
6.67Single5K2BZM2413855K2B-A2A-ZM241385-Na
6.67Single5UVIZM2413855UVI-A2A-ZM241385
6.67Single6AQFZM2413856AQF-A2A-ZM241385
6.67Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
6.67Single6MH8ZM2413856MH8-A2A-ZM241385
6.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
6.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
6.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
6.67Single7AROLUF58337ARO-A2A-LUF5833-Na
6.67Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
6.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
6.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
6.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
6.67Single8K2WAMG4878K2W-CXCR3-AMG487
6.67Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
6.67Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
6.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
6.67Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
6.67Consensusglp_onOrthosteric Ligandglp1_on glp2_on
6.67Consensusgnrh_offOrthosteric Ligandgnrh1_off
6.67Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
6.45Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.45Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
6.45Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
6.25Single3EMLZM2413853EML-A2A-ZM241385
6.25Single4EIYZM2413854EIY-A2A-ZM241385-Na
6.25Single4Z9GCP-3763954Z9G-CRF1-CP-376395
6.25Single5IU8Q274563475IU8-A2A-Q27456347-Na
6.25Single5K2AZM2413855K2A-A2A-ZM241385-Na
6.25Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
6.25Single5OLGZM2413855OLG-A2A-ZM241385-Na
6.25Single5UENDU1725UEN-A1-DU172
6.25Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
6.25Single5VRAZM2413855VRA-A2A-ZM241385-Na
6.25Single6D27CAY104716D27-DP2-CAY10471
6.25Single6S0LZM2413856S0L-A2A-ZM241385
6.25Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.25Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
6.25Single7PYRPSB-21157PYR-A2A-PSB-2115
6.25Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
6.25Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
6.25Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.25Single8GTIBMK-C2058GTI-CRF1-BMK-C205
6.25Consensusa2_offOrthosteric Liganda2a_off
6.25Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
6.25Consensuscck_offOrthosteric Ligandccka_off
6.25Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
6.25Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
6.25Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
6.25Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
6.25Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
6.25Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
6.25Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
6.25Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
6.25Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
5.88Single5IUAQ274563485IUA-A2A-Q27456348-Na
5.88Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
5.88Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
5.88Single6LPLZM2413856LPL-A2A-ZM241385-Na
5.88Single6S0QZM2413856S0Q-A2A-ZM241385
5.88Single6WQAZM2413856WQA-A2A-ZM241385-Na
5.88Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
5.88Single7RM5ZM2413857RM5-A2A-ZM241385-Na
5.88Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.88Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.88Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.88Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.88Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.88Single8FYNZM2413858FYN-A2A-ZM241385-Na
5.88Single8GNEKW-63568GNE-A2A-KW-6356-Na
5.88Single8GTGBMK-I1528GTG-CRF1-BMK-I152
5.88Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
5.88Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.88Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.88Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.56Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
5.56Single6OS1TRV0266OS1-AT1-TRV026
5.56Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Single7F1TMIP-1a7F1T-CCR5-MIP-1a
5.56Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
5.56Single7PX4PSB-21137PX4-A2A-PSB-2113
5.56Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.56Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
5.56Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.56Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.56Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
5.56Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
5.56Consensuscck_onOrthosteric Ligandccka_on cckb_on
5.56Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
5.56Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
5.56Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.56Consensuslpa_onOrthosteric Ligandlpa1_on
5.56Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
5.56Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
5.56Consensusrelaxin_onOrthosteric Ligandrxfp4_on
5.26Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
5.26Single4PY02MeSATP4PY0-P2Y12-2MeSATP
5.26Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
5.26Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
5.26Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
5.26Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
5.26Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.26Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
5.26Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
5.26Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
5.26Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
5.26Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.26Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
5.26Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
5.26Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
5.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
5.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
5.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
5.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
5.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
5.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
5.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
5.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
5.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
5.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.76Single5EE7MK08935EE7-Glucagon-MK0893
4.76Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
4.76Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.76Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
4.76Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
4.76Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.76Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
4.76Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
4.76Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
4.76Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.76Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
4.76Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
4.76Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
4.55Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
4.55Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
4.55Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
4.55Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
4.55Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
4.55Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
4.55Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
4.55Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
4.55Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
4.55Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
4.55Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
4.55Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
4.35Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
4.35Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
4.35Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
4.35Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
4.35Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.35Single7SK5CXCL127SK5-ACKR3-CXCL12
4.35Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
4.35Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
4.35Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
4.35Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
4.35Consensussst_offOrthosteric Ligandsst2_off
4.35Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
4.17Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
4.17Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
4.17Single7XNACYN1548067XNA-SST2-CYN154806
4.17Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
4.17Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
4.17Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
4.17Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
4.17Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
4.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
4.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
4.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
4.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
4.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
4.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
3.85Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.85Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
3.85Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
3.85Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
3.85Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
3.85Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.85Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
3.85Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
3.70Single6FJ3PTH6FJ3-PTH1-PTH
3.70Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.70Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
3.70Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.70Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single7SK3CXCL127SK3-ACKR3-CXCL12
3.70Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
3.70Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.70Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
3.70Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.70Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.70Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.57Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.57Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.57Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.57Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.57Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
3.57Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
3.45Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.45Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.45Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
3.33Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.33Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.33Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.23Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.12Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.03Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.03Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.03Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.03Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.03Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.94Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.78Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
2.70Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.63Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
2.63Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

PDB Summary
PDB 2HPY
Class A
SubFamily Sensory
Type Opsins
SubType Rhodopsin
Species Bos taurus
Ligand All-trans-retinal
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.8
Date 2006-08-22
D.O.I. 10.1073/pnas.0601765103
Net Summary
Imin 3.96
Number of Linked Nodes 344
Number of Links 399
Number of Hubs 63
Number of Links mediated by Hubs 220
Number of Communities 16
Number of Nodes involved in Communities 92
Number of Links involved in Communities 122
Path Summary
Number Of Nodes in MetaPath 66
Number Of Links MetaPath 65
Number of Shortest Paths 222890
Length Of Smallest Path 3
Average Path Length 20.2147
Length of Longest Path 39
Minimum Path Strength 1.515
Average Path Strength 7.79701
Maximum Path Strength 36.175
Minimum Path Correlation 0.7
Average Path Correlation 0.942083
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 46.9914
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.8644
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeRET
PDB ResiduesL:L:?8
Environment DetailsOpen EMBL-EBI Page
CodeRET
NameRETINAL
Synonyms
Identifier(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal
FormulaC20 H28 O
Molecular Weight284.436
SMILESCC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=O)/C)/C
PubChem638015
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

CodeNAG
PDB ResiduesH:H:?6 H:H:?7 H:H:?9 H:H:?10
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeBMA
PDB ResiduesH:H:?8
Environment DetailsOpen EMBL-EBI Page
CodeBMA
Namebeta-D-mannopyranose
Synonymsbeta-D-mannose; D-mannose; mannose
Identifier(2R,3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
FormulaC6 H12 O6
Molecular Weight180.156
SMILESC([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
PubChem439680
Formal Charge0
Total Atoms24
Total Chiral Atoms5
Total Bonds24
Total Aromatic Bonds0

CodePLM
PDB ResiduesH:H:?13 H:H:?14
Environment DetailsOpen EMBL-EBI Page
CodePLM
NamePalmitic Acid
SynonymsHexadecylic acid
Identifierhexadecanoic acid
FormulaC16 H32 O2
Molecular Weight256.424
SMILESCCCCCCCCCCCCCCCC(=O)O
PubChem135369651
Formal Charge0
Total Atoms50
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP02699
Sequence
>2HPY_Chain_R
MNGTEGPNF YVPFSNKTG VVRSPFEAP QYYLAEPWQ FSMLAAYMF 
LLIMLGFPI NFLTLYVTV QHKKLRTPL NYILLNLAV ADLFMVFGG 
FTTTLYTSL HGYFVFGPT GCNLEGFFA TLGGEIALW SLVVLAIER 
YVVVCKPMS NFRFGENHA IMGVAFTWV MALACAAPP LVGWSRYIP 
EGMQCSCGI DYYTPHEET NNESFVIYM FVVHFIIPL IVIFFCYGQ 
LVFTVKEAA AQQQESATT QKAEKEVTR MVIIMVIAF LICWLPYAG 
VAFYIFTHQ GSDFGPIFM TIPAFFAKT SAVYNPVIY IMMNKQFRN 
CMVTTLCCG KNPLGDDEA STTVSKTET SQVAPA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
1F88ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82000-08-0410.1126/science.289.5480.739
1GZMASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652003-11-2010.1016/j.jmb.2004.08.090
1HZXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82001-07-0410.1021/bi0155091
1L9HASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62002-05-1510.1073/pnas.082666399
1U19ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.22004-10-1210.1016/j.jmb.2004.07.044
2G87ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--2.62006-09-0210.1002/anie.200600595
2HPYASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--2.82006-08-2210.1073/pnas.0601765103
2I35ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.82006-10-1710.1073/pnas.0608022103
2I36ASensoryOpsinsRhodopsinBos taurus---4.12006-10-1710.1073/pnas.0608022103
2I37ASensoryOpsinsRhodopsinBos taurus---4.152006-10-1710.1073/pnas.0608022103
2J4YASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42007-09-2510.1016/j.jmb.2007.03.007
2PEDASensoryOpsinsRhodopsinBos taurus9-cis-Retinal--2.952007-10-3010.1529/biophysj.107.108225
2X72ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)32011-03-1610.1038/nature09795
2Z73ASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--2.52008-05-1310.1038/nature06925
2ZIYASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--3.72008-05-0610.1074/jbc.C800040200
3AYMASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-retinal--2.82011-08-1710.1016/j.jmb.2011.08.044
3AYNASensoryOpsinsRhodopsinTodarodes pacificus9-cis-Retinal--2.72011-08-1710.1016/j.jmb.2011.08.044
3C9LASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652008-08-0510.1107/S0907444908017162
3C9MASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42008-08-0510.1107/S0907444908017162
3CAPASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
3DQBASensoryOpsinsRhodopsinBos taurus--Gt(CT)3.22008-09-2310.1038/nature07330
3OAXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62011-01-1910.1016/j.bpj.2010.08.003
3PQRASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)2.852011-03-0910.1038/nature09789
3PXOASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--32011-03-0910.1038/nature09789
4A4MASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)3.32012-01-2510.1073/pnas.1114089108
4BEYASensoryOpsinsRhodopsinBos taurus--Gt(CT)2.92013-05-0810.1038/embor.2013.44
4BEZASensoryOpsinsRhodopsinBos taurus---3.32013-04-2410.1038/embor.2013.44
4J4QASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Gt(CT)2.652013-10-3010.1002/anie.201302374
4PXFASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop2.752014-09-1710.1038/ncomms5801
4WW3ASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-retinal--2.82015-06-1710.1371/journal.pone.0126970
4X1HASensoryOpsinsRhodopsinBos taurusNonyl Beta-D-Glucopyranoside-Gt(CT)2.292015-11-0410.1016/j.str.2015.09.015
4ZWJASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.32015-07-2910.1038/nature14656
5DGYASensoryOpsinsRhodopsinHomo sapiens--Arrestin17.72016-03-2310.1038/sdata.2016.21
5DYSASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--2.32016-08-1010.15252/embr.201642671
5EN0ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)2.812016-08-1010.15252/embr.201642671
5TE3ASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside--2.72017-03-1510.1073/pnas.1617446114
5TE5ASensoryOpsinsRhodopsinBos taurus20-Methanoretinal--4.012017-03-1510.1073/pnas.1617446114
5W0PASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.012017-08-0910.1016/j.cell.2017.07.002
5WKTASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Gt(CT)3.22017-12-1310.1038/nprot.2017.135
6CMOASensoryOpsinsRhodopsinHomo sapiens--Gi1/&β;1/&γ;24.52018-06-2010.1038/s41586-018-0215-y
6FK6ASensoryOpsinsRhodopsinBos taurus-PubChem 132473033-2.362018-04-0410.1073/pnas.1718084115
6FK7ASensoryOpsinsRhodopsinBos taurus-PubChem 132473034-2.622018-04-0410.1073/pnas.1718084115
6FK8ASensoryOpsinsRhodopsinBos taurus-PubChem 132473035-2.872018-04-0410.1073/pnas.1718084115
6FK9ASensoryOpsinsRhodopsinBos taurus-PubChem 132473036-2.632018-04-0410.1073/pnas.1718084115
6FKAASensoryOpsinsRhodopsinBos taurus-PubChem 132473037-2.72018-04-0410.1073/pnas.1718084115
6FKBASensoryOpsinsRhodopsinBos taurus-PubChem 132473038-3.032018-04-0410.1073/pnas.1718084115
6FKCASensoryOpsinsRhodopsinBos taurus-PubChem 132473039-2.462018-04-0410.1073/pnas.1718084115
6FKDASensoryOpsinsRhodopsinBos taurus-PubChem 137349183-2.492018-04-0410.1073/pnas.1718084115
6FUFASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Go/&β;1/&γ;23.122018-10-0310.1126/sciadv.aat7052
6I9KASensoryOpsinsRhodopsinHasarius adansoni9-cis-Retinal--2.152019-07-0310.1073/pnas.1902192116
6NWEASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Gt(CT)2.712020-02-12To be published
6OFJASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
6OY9ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt/&β;1/&γ;13.92019-07-2410.1016/j.molcel.2019.06.007
6OYAASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt/&β;1/&γ;13.32019-07-2410.1016/j.molcel.2019.06.007
6PELASensoryOpsinsRhodopsinBos taurus-CitronellolGt(CT)3.192020-06-24To be published
6PGSASensoryOpsinsRhodopsinBos taurus-GeraniolGt(CT)2.92020-07-01To be published
6PH7ASensoryOpsinsRhodopsinBos taurus-NerolGt(CT)2.92020-07-01To be published
6QNOASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gi1/&β;1/&γ;14.382019-07-1010.7554/eLife.46041
7MT8ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK15.82021-07-0710.1038/s41586-021-03721-x
7MT9ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK172021-07-0710.1038/s41586-021-03721-x
7MTAASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK14.12021-07-0710.1038/s41586-021-03721-x
7MTBASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK142021-07-0710.1038/s41586-021-03721-x
7ZBCASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7ZBEASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6CASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6DASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6EASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--1.82023-03-2910.1038/s41586-023-05863-6
8FCZASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-3010.1038/s41467-023-40911-9
8FD0ASensoryOpsinsRhodopsinBos taurus---3.712023-08-3010.1038/s41467-023-40911-9
8FD1ASensoryOpsinsRhodopsinBos taurus---4.252023-08-3010.1038/s41467-023-40911-9
3CAP (Dimer)ASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
6OFJ (Dimer)ASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
8FCZ (Dimer)ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-3010.1038/s41467-023-40911-9
8FD0 (Dimer)ASensoryOpsinsRhodopsinBos taurus---3.712023-08-3010.1038/s41467-023-40911-9
8FD1 (Dimer)ASensoryOpsinsRhodopsinBos taurus---4.252023-08-3010.1038/s41467-023-40911-9




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