psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D282	R:R:N2	12.12	No	No	0	2	6
2	R:R:G3	R:R:Y10	4.35	No	No	0	6	7
3	R:R:N15	R:R:T4	7.31	Yes	No	1	7	6
4	R:R:T4	R:R:V20	11.11	No	Yes	1	6	6
5	H:H:?1	R:R:T4	5.29	Yes	No	1	0	6
6	R:R:G6	R:R:P7	4.06	No	No	0	6	6
7	R:R:F9	R:R:G6	9.03	No	No	0	7	6
8	R:R:F9	R:R:S22	6.61	No	Yes	1	7	5
9	R:R:F9	R:R:P23	15.89	No	Yes	1	7	5
10	R:R:T193	R:R:Y10	7.49	No	No	0	5	7
11	R:R:P12	R:R:V11	3.53	No	Yes	1	8	8
12	R:R:V11	R:R:V20	4.81	Yes	Yes	1	8	6
13	R:R:P23	R:R:V11	3.53	Yes	Yes	1	5	8
14	R:R:Q28	R:R:V11	4.3	Yes	Yes	1	5	8
15	R:R:V11	R:R:Y30	5.05	Yes	Yes	1	8	4
16	R:R:Q184	R:R:V11	4.3	Yes	Yes	1	3	8
17	R:R:P12	R:R:Q184	4.74	No	Yes	1	8	3
18	R:R:F13	R:R:V20	5.24	No	Yes	1	4	6
19	R:R:F13	R:R:Y30	8.25	No	Yes	1	4	4
20	R:R:K16	R:R:S14	6.12	No	No	0	7	4
21	R:R:G18	R:R:N15	3.39	No	Yes	1	3	7
22	R:R:N15	R:R:V20	10.35	Yes	Yes	1	7	6
23	H:H:?1	R:R:N15	25.87	Yes	Yes	1	0	7
24	R:R:T17	R:R:V19	6.35	No	No	0	6	3
25	H:H:?1	R:R:G18	6.14	Yes	No	1	0	3
26	R:R:V19	R:R:Y30	3.79	No	Yes	0	3	4
27	R:R:V20	R:R:Y30	11.36	Yes	Yes	1	6	4
28	H:H:?1	R:R:V20	6.68	Yes	Yes	1	0	6
29	H:H:?1	R:R:R21	5.45	Yes	No	1	0	4
30	H:H:?2	R:R:R21	9.81	No	No	1	0	4
31	R:R:P23	R:R:S22	5.34	Yes	Yes	1	5	5
32	R:R:F24	R:R:S22	3.96	Yes	Yes	1	5	5
33	R:R:E25	R:R:S22	4.31	No	Yes	0	7	5
34	R:R:P23	R:R:Q28	4.74	Yes	Yes	1	5	5
35	R:R:P180	R:R:P23	5.84	Yes	Yes	1	3	5
36	R:R:P23	R:R:Q184	7.9	Yes	Yes	1	5	3
37	R:R:F103	R:R:F24	5.36	Yes	Yes	1	8	5
38	R:R:F24	R:R:G106	6.02	Yes	No	1	5	8
39	R:R:F24	R:R:P107	10.11	Yes	No	1	5	3
40	R:R:C110	R:R:F24	4.19	Yes	Yes	1	9	5
41	R:R:F24	R:R:P180	7.22	Yes	Yes	1	5	3
42	R:R:P27	R:R:Y29	6.95	No	Yes	0	8	4
43	R:R:P27	R:R:Y102	6.95	No	No	0	8	4
44	R:R:Q28	R:R:Y30	12.4	Yes	Yes	1	5	4
45	R:R:L31	R:R:Q28	6.65	No	Yes	1	4	5
46	R:R:Q184	R:R:Q28	5.12	Yes	Yes	1	3	5
47	R:R:P34	R:R:Y29	11.13	No	Yes	0	3	4
48	R:R:F37	R:R:Y29	5.16	No	Yes	0	5	4
49	R:R:G101	R:R:Y29	4.35	No	Yes	0	4	4
50	R:R:L31	R:R:Y30	4.69	No	Yes	1	4	4
51	R:R:L31	R:R:P285	4.93	No	No	0	4	3
52	R:R:A32	R:R:Q36	4.55	No	Yes	0	3	2
53	R:R:A32	R:R:F37	4.16	No	No	0	3	5
54	R:R:E33	R:R:W35	13.08	No	No	4	3	3
55	R:R:E33	R:R:Q36	5.1	No	Yes	4	3	2
56	R:R:Q36	R:R:W35	12.05	Yes	No	4	2	3
57	R:R:I286	R:R:Q36	4.12	No	Yes	0	1	2
58	R:R:F37	R:R:M183	6.22	No	No	0	5	2
59	R:R:L40	R:R:T94	4.42	No	No	0	5	7
60	R:R:L40	R:R:M183	7.07	No	No	0	5	2
61	R:R:A41	R:R:S98	3.42	No	No	0	5	5
62	R:R:L47	R:R:Y43	10.55	No	Yes	2	7	4
63	R:R:F293	R:R:Y43	10.32	No	Yes	0	5	4
64	R:R:T297	R:R:Y43	6.24	No	Yes	2	6	4
65	R:R:M44	R:R:T94	6.02	No	No	0	7	7
66	R:R:F45	R:R:M49	14.93	No	No	0	3	5
67	R:R:L46	R:R:L50	4.15	No	No	0	5	5
68	R:R:F91	R:R:L47	12.18	Yes	No	0	7	7
69	R:R:L47	R:R:T297	4.42	No	No	2	7	6
70	R:R:I48	R:R:T92	4.56	No	No	0	6	8
71	R:R:F52	R:R:P53	4.33	No	No	0	6	4
72	R:R:F52	R:R:F56	7.5	No	No	0	6	4
73	R:R:F52	R:R:F88	5.36	No	No	0	6	4
74	R:R:I54	R:R:P303	3.39	No	No	0	8	9
75	R:R:D83	R:R:N55	12.12	No	Yes	0	9	9
76	R:R:N55	R:R:P303	8.15	Yes	No	0	9	9
77	R:R:L57	R:R:M317	11.31	No	No	0	6	6
78	R:R:L321	R:R:L57	5.54	No	No	0	6	6
79	R:R:I307	R:R:T58	10.64	No	No	0	7	9
80	R:R:L59	R:R:L77	4.15	No	No	0	7	5
81	R:R:Q64	R:R:Y60	16.91	No	No	0	5	3
82	R:R:M317	R:R:V61	4.56	No	No	0	6	7
83	R:R:T320	R:R:V61	6.35	No	No	0	5	7
84	R:R:L77	R:R:T62	11.79	No	No	0	5	7
85	R:R:Q64	R:R:T320	4.25	No	No	0	5	5
86	R:R:H65	R:R:L68	5.14	Yes	No	5	5	7
87	R:R:C316	R:R:H65	17.69	No	Yes	5	5	5
88	R:R:H65	R:R:T320	4.11	Yes	No	0	5	5
89	R:R:K66	R:R:K67	7.18	No	No	0	6	5
90	R:R:K66	R:R:R69	3.71	No	No	0	6	6
91	R:R:F313	R:R:L68	9.74	Yes	No	0	8	7
92	R:R:C316	R:R:L68	6.35	No	No	5	5	7
93	R:R:N73	R:R:T70	5.85	No	No	0	8	7
94	R:R:F148	R:R:L72	6.09	Yes	No	0	7	8
95	R:R:F313	R:R:N73	6.04	Yes	No	0	8	8
96	R:R:E150	R:R:Y74	7.86	No	No	0	2	5
97	R:R:A153	R:R:Y74	5.34	No	No	0	7	5
98	R:R:I75	R:R:S127	6.19	Yes	No	3	7	8
99	R:R:I75	R:R:V130	6.14	Yes	No	3	7	7
100	R:R:I75	R:R:L131	4.28	Yes	No	0	7	9
101	R:R:E134	R:R:I75	4.1	No	Yes	3	8	7
102	R:R:I307	R:R:L76	5.71	No	No	0	7	8
103	R:R:I123	R:R:N78	4.25	Yes	Yes	3	7	9
104	R:R:N78	R:R:S127	5.96	Yes	No	3	9	8
105	R:R:N78	R:R:V157	7.39	Yes	No	3	9	7
106	R:R:N78	R:R:T160	7.31	Yes	No	3	9	7
107	R:R:N78	R:R:W161	7.91	Yes	Yes	3	9	9
108	R:R:D83	R:R:L79	4.07	No	No	0	9	9
109	R:R:L79	R:R:Y306	3.52	No	Yes	0	9	9
110	R:R:A299	R:R:D83	4.63	No	No	0	9	9
111	R:R:F91	R:R:M86	3.73	Yes	No	0	7	7
112	R:R:G121	R:R:M86	3.49	No	No	0	7	7
113	R:R:F88	R:R:V87	6.55	No	No	0	4	6
114	R:R:F91	R:R:V87	3.93	Yes	No	0	7	6
115	R:R:E113	R:R:G90	4.91	No	No	0	5	6
116	R:R:F91	R:R:K296	9.93	Yes	No	0	7	7
117	R:R:E113	R:R:T93	5.64	No	No	0	5	5
118	R:R:H100	R:R:Y96	15.24	No	No	0	4	4
119	R:R:F105	R:R:Y96	5.16	No	No	0	7	4
120	R:R:C185	R:R:T97	5.07	No	No	0	5	5
121	R:R:C185	R:R:S98	3.44	No	No	0	5	5
122	R:R:H100	R:R:V104	6.92	No	No	0	4	4
123	R:R:V104	R:R:Y102	11.36	No	No	0	4	4
124	R:R:F103	R:R:F105	6.43	Yes	No	0	8	7
125	R:R:C110	R:R:F103	4.19	Yes	Yes	1	9	8
126	R:R:E113	R:R:F103	5.83	No	Yes	0	5	8
127	R:R:C187	R:R:F103	6.98	No	Yes	1	9	8
128	R:R:F105	R:R:V104	7.87	No	No	0	7	4
129	R:R:G106	R:R:P107	4.06	No	No	1	8	3
130	R:R:G109	R:R:T108	3.64	No	No	0	5	1
131	R:R:G109	R:R:L112	3.42	No	No	0	5	4
132	R:R:C110	R:R:P180	3.77	Yes	Yes	1	9	3
133	R:R:C110	R:R:C187	7.28	Yes	No	1	9	9
134	R:R:L172	R:R:N111	4.12	No	No	0	5	7
135	R:R:G114	R:R:Y178	5.79	No	Yes	0	5	3
136	R:R:F115	R:R:F116	6.43	No	No	0	6	4
137	R:R:F115	R:R:L172	6.09	No	No	0	6	5
138	R:R:T118	R:R:Y178	7.49	No	Yes	0	4	3
139	R:R:I123	R:R:L119	7.14	Yes	No	0	7	5
140	R:R:C167	R:R:E122	9.12	No	No	1	5	6
141	R:R:E122	R:R:H211	3.69	No	Yes	1	6	6
142	R:R:E122	W:W:?3	5.1	No	Yes	1	6	0
143	R:R:I123	R:R:W161	5.87	Yes	Yes	3	7	9
144	R:R:L125	R:R:W126	5.69	No	Yes	0	7	5
145	R:R:F261	R:R:L125	4.87	Yes	No	2	9	7
146	R:R:L125	R:R:W265	14.81	No	No	2	7	8
147	R:R:V129	R:R:W126	6.13	No	Yes	0	7	5
148	R:R:M163	R:R:W126	16.29	No	Yes	0	4	5
149	R:R:H211	R:R:W126	9.52	Yes	Yes	0	6	5
150	R:R:P215	R:R:W126	8.11	No	Yes	0	9	5
151	R:R:S127	R:R:T160	6.4	No	No	3	8	7
152	R:R:F261	R:R:L128	3.65	Yes	No	0	9	8
153	R:R:L128	R:R:Y306	14.07	No	Yes	0	8	9
154	R:R:E134	R:R:V130	4.28	No	No	3	8	7
155	R:R:L131	R:R:R135	17.01	No	No	0	9	9
156	R:R:A132	R:R:Y223	8.01	No	Yes	0	9	9
157	R:R:E134	R:R:F148	12.83	No	Yes	0	8	7
158	R:R:R135	R:R:Y223	6.17	No	Yes	0	9	9
159	R:R:C140	R:R:Y136	5.38	No	Yes	0	7	7
160	R:R:P142	R:R:Y136	12.52	No	Yes	0	8	7
161	R:R:F221	R:R:Y136	6.19	No	Yes	6	4	7
162	R:R:C222	R:R:Y136	6.72	No	Yes	0	8	7
163	R:R:Q225	R:R:Y136	4.51	No	Yes	6	4	7
164	R:R:F146	R:R:V137	3.93	No	No	0	5	4
165	R:R:F148	R:R:V138	3.93	Yes	No	0	7	8
166	R:R:L226	R:R:V139	7.45	No	No	0	8	8
167	R:R:C140	R:R:T229	5.07	No	No	0	7	6
168	R:R:F146	R:R:M143	9.95	No	No	0	5	6
169	R:R:F146	R:R:H152	7.92	No	No	0	5	5
170	R:R:G149	R:R:R147	7.51	No	No	0	6	4
171	R:R:H152	R:R:R147	3.39	No	No	0	5	4
172	R:R:F148	R:R:H152	4.53	Yes	No	0	7	5
173	R:R:V157	R:R:W161	4.9	No	Yes	3	7	9
174	R:R:F159	R:R:M163	11.2	No	No	0	3	4
175	R:R:T160	R:R:W161	4.85	No	Yes	3	7	9
176	R:R:C167	R:R:M207	4.86	No	Yes	1	5	5
177	R:R:C167	R:R:H211	8.85	No	Yes	1	5	6
178	R:R:P170	R:R:P171	5.84	Yes	No	1	7	5
179	R:R:P170	R:R:W175	6.76	Yes	Yes	1	7	5
180	R:R:F203	R:R:P170	4.33	Yes	Yes	1	6	7
181	R:R:P171	R:R:Y178	15.3	No	Yes	0	5	3
182	R:R:F203	R:R:P171	7.22	Yes	No	1	6	5
183	R:R:L172	R:R:Y178	3.52	No	Yes	0	5	3
184	R:R:S202	R:R:W175	8.65	No	Yes	0	4	5
185	R:R:F203	R:R:W175	23.05	Yes	Yes	1	6	5
186	R:R:W175	R:R:Y206	10.61	Yes	Yes	1	5	4
187	R:R:N200	R:R:S176	7.45	Yes	No	0	4	5
188	R:R:F203	R:R:S176	9.25	Yes	No	0	6	5
189	R:R:I179	R:R:R177	10.02	Yes	Yes	1	1	5
190	R:R:D190	R:R:R177	11.91	Yes	Yes	1	4	5
191	R:R:R177	R:R:T193	6.47	Yes	No	1	5	5
192	R:R:H195	R:R:R177	27.08	Yes	Yes	1	4	5
193	R:R:I179	R:R:P180	3.39	Yes	Yes	1	1	3
194	R:R:D190	R:R:I179	9.8	Yes	Yes	1	4	1
195	R:R:I179	R:R:Y192	4.84	Yes	Yes	1	1	5
196	R:R:P180	R:R:Q184	6.32	Yes	Yes	1	3	3
197	R:R:C187	R:R:P180	5.65	No	Yes	1	9	3
198	R:R:E181	R:R:S186	5.75	No	No	0	4	5
199	R:R:E181	R:R:G188	4.91	No	No	0	4	5
200	R:R:E181	R:R:Y192	7.86	No	Yes	0	4	5
201	R:R:G182	R:R:M288	5.24	No	No	0	3	4
202	R:R:F203	R:R:I189	6.28	Yes	No	0	6	4
203	R:R:D190	R:R:Y192	8.05	Yes	Yes	1	4	5
204	R:R:D190	R:R:T193	11.56	Yes	No	1	4	5
205	R:R:D190	R:R:N200	5.39	Yes	Yes	1	4	4
206	R:R:Y191	R:R:Y192	16.88	Yes	Yes	1	6	5
207	R:R:Y191	R:R:Y268	5.96	Yes	Yes	1	6	6
208	R:R:A272	R:R:Y191	5.34	No	Yes	1	5	6
209	R:R:I275	R:R:Y191	6.04	No	Yes	1	4	6
210	R:R:Y191	W:W:?3	5.64	Yes	Yes	1	6	0
211	R:R:M288	R:R:Y192	7.18	No	Yes	0	4	5
212	R:R:E196	R:R:P194	4.72	No	No	0	1	1
213	R:R:P194	R:R:Q279	14.21	No	No	0	1	1
214	R:R:E197	R:R:H195	20.92	No	Yes	0	3	4
215	R:R:H195	R:R:T198	10.95	Yes	No	1	4	1
216	R:R:H195	R:R:N200	5.1	Yes	Yes	1	4	4
217	R:R:N200	R:R:T198	5.85	Yes	No	1	4	1
218	R:R:E201	R:R:F276	4.66	No	No	0	3	4
219	R:R:F203	R:R:M207	8.71	Yes	Yes	1	6	5
220	R:R:F276	R:R:V204	14.42	No	No	0	4	4
221	R:R:V210	R:R:Y206	7.57	No	Yes	1	4	4
222	R:R:H211	R:R:Y206	9.8	Yes	Yes	1	6	4
223	R:R:H211	R:R:M207	3.94	Yes	Yes	1	6	5
224	R:R:M207	W:W:?3	6.8	Yes	Yes	1	5	0
225	R:R:F208	R:R:F212	5.36	No	Yes	1	5	8
226	R:R:F208	R:R:I213	7.54	No	No	1	5	4
227	R:R:F208	W:W:?3	3.52	No	Yes	1	5	0
228	R:R:H211	R:R:V210	9.69	Yes	No	1	6	4
229	R:R:F212	R:R:I213	3.77	Yes	No	1	8	4
230	R:R:A269	R:R:F212	8.32	No	Yes	1	7	8
231	R:R:F212	W:W:?3	14.07	Yes	Yes	1	8	0
232	R:R:I214	R:R:P215	3.39	No	No	0	5	9
233	R:R:F220	R:R:L216	4.87	No	No	0	5	7
234	R:R:F261	R:R:I219	7.54	Yes	No	0	9	8
235	R:R:F220	R:R:V258	3.93	No	No	0	5	8
236	R:R:F221	R:R:Q225	10.54	No	No	6	4	4
237	R:R:V254	R:R:Y223	3.79	No	Yes	0	8	9
238	R:R:M257	R:R:Y223	11.97	No	Yes	0	8	9
239	R:R:K231	R:R:V227	4.55	No	No	0	5	5
240	R:R:V227	R:R:V254	4.81	No	No	0	5	8
241	R:R:E232	R:R:F228	9.33	No	No	0	4	3
242	R:R:V230	R:R:V250	4.81	No	No	0	8	8
243	R:R:E247	R:R:K231	10.8	Yes	No	7	7	5
244	R:R:K231	R:R:T251	10.51	No	No	7	5	6
245	R:R:A234	R:R:Q244	4.55	No	No	0	5	4
246	R:R:E239	R:R:Q237	6.37	No	No	0	2	5
247	R:R:Q237	R:R:T243	4.25	No	No	0	5	5
248	R:R:S240	R:R:T243	6.4	No	No	0	4	5
249	R:R:E247	R:R:K248	4.05	Yes	No	0	7	4
250	R:R:E247	R:R:T251	4.23	Yes	No	7	7	6
251	R:R:E249	R:R:R252	5.82	No	No	0	7	7
252	R:R:I256	R:R:I305	4.42	No	No	0	5	8
253	R:R:M257	R:R:Y306	11.97	No	Yes	0	8	9
254	R:R:F261	R:R:W265	9.02	Yes	No	2	9	8
255	R:R:F294	R:R:I263	3.77	No	No	0	7	5
256	R:R:C264	R:R:W265	11.75	No	No	2	8	8
257	R:R:C264	R:R:S298	3.44	No	No	2	8	9
258	R:R:C264	R:R:Y301	4.03	No	Yes	2	8	5
259	R:R:F294	R:R:P267	4.33	No	No	0	7	9
260	R:R:P291	R:R:Y268	6.95	No	Yes	0	6	6
261	R:R:Y268	W:W:?3	9.03	Yes	Yes	1	6	0
262	R:R:A269	W:W:?3	4.55	No	Yes	1	7	0
263	R:R:F287	R:R:V271	3.93	No	No	0	4	5
264	R:R:P291	R:R:V271	10.6	No	No	0	6	5
265	R:R:A272	W:W:?3	4.55	No	Yes	1	5	0
266	R:R:F273	R:R:T277	7.78	No	No	0	6	5
267	R:R:H278	R:R:Y274	17.42	No	No	0	3	4
268	R:R:F283	R:R:I275	15.07	Yes	No	1	4	4
269	R:R:F287	R:R:I275	6.28	No	No	1	4	4
270	R:R:H278	R:R:T277	4.11	No	No	0	3	5
271	R:R:F283	R:R:S281	7.93	Yes	No	0	4	4
272	R:R:F283	R:R:F287	8.57	Yes	No	1	4	4
273	R:R:G284	R:R:P285	4.06	No	No	0	4	3
274	R:R:I290	R:R:P291	3.39	No	No	0	5	6
275	R:R:F293	R:R:F294	9.65	No	No	0	5	7
276	R:R:T297	R:R:Y301	4.99	No	Yes	2	6	5
277	R:R:S298	R:R:Y301	5.09	No	Yes	2	9	5
278	R:R:N302	R:R:S298	5.96	No	No	2	9	9
279	R:R:N302	R:R:Y301	4.65	No	Yes	2	9	5
280	R:R:N302	R:R:Y306	4.65	No	Yes	0	9	9
281	R:R:I305	R:R:Y306	6.04	No	Yes	0	8	9
282	R:R:F313	R:R:I307	11.3	Yes	No	0	8	7
283	R:R:F313	R:R:N310	7.25	Yes	No	0	8	8
284	R:R:N326	R:R:V318	4.43	No	No	0	3	3
285	R:R:C322	R:R:N326	4.72	No	No	0	4	3
286	H:H:?4	R:R:C323	9.74	No	No	0	0	9
287	H:H:?1	H:H:?2	41.23	Yes	No	1	0	0
288	H:H:?2	H:H:?3	29.87	No	No	0	0	0
289	R:R:A80	R:R:T58	3.36	No	No	0	9	9
290	R:R:A168	R:R:T118	3.36	No	No	0	7	4
291	R:R:L266	R:R:P267	3.28	No	No	0	6	9
292	R:R:N8	R:R:P107	3.26	No	No	0	4	3
293	R:R:A82	R:R:I123	3.25	No	Yes	0	8	7
294	R:R:V129	R:R:V218	3.21	No	No	0	7	6
295	R:R:A292	R:R:K296	3.21	No	No	0	5	7
296	R:R:S240	R:R:T242	3.2	No	No	0	4	4
297	R:R:C185	R:R:L40	3.17	No	No	0	5	5
298	R:R:A41	R:R:L99	3.15	No	No	0	5	4
299	R:R:A80	R:R:L59	3.15	No	No	0	9	7
300	R:R:A80	R:R:N55	3.13	No	Yes	0	9	9
301	R:R:I48	R:R:V87	3.07	No	No	0	6	6
302	R:R:I133	R:R:V218	3.07	No	No	0	6	6
303	R:R:A234	R:R:E247	3.02	No	Yes	0	5	7
304	R:R:F103	R:R:G109	3.01	Yes	No	0	8	5
305	R:R:L50	R:R:V300	2.98	No	No	0	5	7
306	R:R:L59	R:R:V81	2.98	No	No	0	7	6
307	R:R:I213	R:R:I217	2.94	No	No	0	4	4
308	R:R:I255	R:R:I259	2.94	No	No	0	5	5
309	R:R:I259	R:R:I263	2.94	No	No	0	5	5
310	R:R:I48	R:R:M49	2.92	No	No	0	6	5
311	R:R:M253	R:R:M257	2.89	No	No	0	8	8
312	R:R:E247	R:R:V230	2.85	Yes	No	0	7	8
313	R:R:Q244	R:R:T243	2.83	No	No	0	4	5
314	R:R:A26	R:R:R21	2.77	No	No	0	2	4
315	R:R:L119	R:R:L165	2.77	No	No	0	5	3
316	R:R:A153	R:R:F148	2.77	No	Yes	0	7	7
317	R:R:L216	R:R:L262	2.77	No	No	0	7	6
318	R:R:L84	R:R:N55	2.75	No	Yes	0	7	9
319	R:R:H65	R:R:T319	2.74	Yes	No	0	5	4
320	R:R:K67	R:R:Q312	2.71	No	No	0	5	6
321	R:R:E249	R:R:M253	2.71	No	No	0	7	8
322	R:R:N310	R:R:Q312	2.64	No	No	0	8	6
323	R:R:F85	R:R:V81	2.62	No	No	0	6	6
324	R:R:Q238	R:R:Q244	2.56	No	No	0	5	4
325	R:R:E196	R:R:E197	2.54	No	No	0	1	3
326	R:R:K311	R:R:R314	2.48	No	No	0	4	8
327	R:R:F261	R:R:L216	2.44	Yes	No	0	9	7
328	R:R:I154	R:R:Y74	2.42	No	No	0	3	5
329	R:R:L46	R:R:Y43	2.34	No	Yes	0	5	4
330	R:R:F276	R:R:Q279	2.34	No	No	0	4	1
331	R:R:M39	R:R:W35	2.33	No	No	0	4	3
332	R:R:N199	R:R:W175	2.26	No	Yes	0	3	5
333	R:R:E5	R:R:Y10	2.24	No	No	0	6	7
334	R:R:G89	R:R:G90	2.11	No	No	0	4	6
335	R:R:G120	R:R:G121	2.11	No	No	0	8	7
336	R:R:F283	R:R:Y274	2.06	Yes	No	0	4	4
337	R:R:A269	R:R:G270	1.95	No	No	0	7	5
338	R:R:A153	R:R:P71	1.87	No	No	0	7	6
339	R:R:A169	R:R:P170	1.87	No	Yes	0	3	7
340	R:R:G51	R:R:V300	1.84	No	No	0	8	7
341	R:R:G156	R:R:V130	1.84	No	No	0	6	7
342	R:R:G174	R:R:T198	1.82	No	No	0	5	1
343	R:R:G324	R:R:T319	1.82	No	No	0	3	4
344	R:R:A132	R:R:C222	1.81	No	No	0	9	8
345	R:R:A124	R:R:A82	1.79	No	No	0	9	8
346	R:R:A292	R:R:T289	1.68	No	No	0	5	4
347	R:R:K141	R:R:P142	1.67	No	No	0	6	8
348	R:R:G280	R:R:Q279	1.64	No	No	0	1	1
349	R:R:A164	R:R:I123	1.62	No	Yes	0	8	7
350	R:R:A260	R:R:I305	1.62	No	No	0	7	8
351	R:R:A42	R:R:M39	1.61	No	No	0	5	4
352	R:R:V139	R:R:V230	1.6	No	No	0	8	8
353	R:R:A41	R:R:L95	1.58	No	No	0	5	6
354	R:R:I205	R:R:V209	1.54	No	No	0	5	5
355	R:R:M163	R:R:V162	1.52	No	No	0	4	4
356	R:R:A235	R:R:Q238	1.52	No	No	0	4	5
357	R:R:M308	R:R:V304	1.52	No	No	0	6	7
358	R:R:K16	R:R:T17	1.5	No	No	0	7	6
359	R:R:N145	R:R:S144	1.49	No	No	0	5	4
360	R:R:I54	R:R:M308	1.46	No	No	0	8	6
361	R:R:M253	R:R:M309	1.44	No	No	0	8	7
362	R:R:K311	R:R:N315	1.4	No	No	0	4	5
363	R:R:E201	R:R:I205	1.37	No	No	0	3	5
364	R:R:A166	R:R:Y206	1.33	No	Yes	0	4	4
365	R:R:A295	R:R:Y268	1.33	No	Yes	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V11	4.25333	6	1	8
2	R:R:N15	11.73	4	1	7
3	R:R:V20	8.25833	6	1	6
4	R:R:S22	5.055	4	1	5
5	R:R:P23	7.20667	6	1	5
6	R:R:F24	6.14333	6	1	5
7	R:R:Q28	6.642	5	1	5
8	R:R:Y29	6.8975	4	0	4
9	R:R:Y30	7.59	6	1	4
10	R:R:Q36	6.455	4	4	2
11	R:R:Y43	7.3625	4	2	4
12	R:R:N55	6.5375	4	0	9
13	R:R:H65	7.42	4	5	5
14	R:R:I75	5.1775	4	3	7
15	R:R:N78	6.564	5	3	9
16	R:R:F91	7.4425	4	0	7
17	R:R:F103	5.3	6	1	8
18	R:R:C110	4.8575	4	1	9
19	R:R:I123	4.426	5	3	7
20	R:R:W126	9.148	5	0	5
21	R:R:Y136	7.064	5	6	7
22	R:R:F148	6.03	5	0	7
23	R:R:W161	5.8825	4	3	9
24	R:R:P170	4.7	4	1	7
25	R:R:W175	10.266	5	1	5
26	R:R:R177	13.87	4	1	5
27	R:R:Y178	8.025	4	0	3
28	R:R:I179	7.0125	4	1	1
29	R:R:P180	5.365	6	1	3
30	R:R:Q184	5.676	5	1	3
31	R:R:D190	9.342	5	1	4
32	R:R:Y191	7.972	5	1	6
33	R:R:Y192	8.962	5	1	5
34	R:R:H195	16.0125	4	1	4
35	R:R:N200	5.9475	4	1	4
36	R:R:F203	9.80667	6	1	6
37	R:R:Y206	7.3275	4	1	4
38	R:R:M207	6.0775	4	1	5
39	R:R:H211	7.58167	6	1	6
40	R:R:F212	7.88	4	1	8
41	R:R:Y223	7.485	4	0	9
42	R:R:E247	4.99	5	7	7
43	R:R:F261	5.504	5	2	9
44	R:R:Y268	5.8175	4	1	6
45	R:R:F283	8.4075	4	1	4
46	R:R:Y301	4.69	4	2	5
47	R:R:Y306	8.05	5	0	9
48	R:R:F313	8.5825	4	0	8
49	W:W:?3	6.6575	8	1	0
50	H:H:?1	15.11	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I179	R:R:P180	95.2198	3.39	Yes	Yes	1	1	3
2	R:R:P180	R:R:P23	22.149	5.84	Yes	Yes	1	3	5
3	R:R:P23	R:R:V11	13.156	3.53	Yes	Yes	1	5	8
4	R:R:V11	R:R:V20	15.4626	4.81	Yes	Yes	1	8	6
5	R:R:P180	R:R:Q184	20.1459	6.32	Yes	Yes	1	3	3
6	R:R:Q184	R:R:V11	12.1168	4.3	Yes	Yes	1	3	8
7	R:R:F24	R:R:P180	25.1581	7.22	Yes	Yes	1	5	3
8	R:R:V19	R:R:Y30	11.3416	3.79	No	Yes	0	3	4
9	R:R:F103	R:R:F24	23.433	5.36	Yes	Yes	1	8	5
10	R:R:C110	R:R:F103	21.7563	4.19	Yes	Yes	1	9	8
11	R:R:C110	R:R:P180	22.3173	3.77	Yes	Yes	1	9	3
12	R:R:C187	R:R:F103	21.7639	6.98	No	Yes	1	9	8
13	R:R:C187	R:R:P180	22.3275	5.65	No	Yes	1	9	3
14	R:R:F103	R:R:F105	52.3729	6.43	Yes	No	0	8	7
15	R:R:F105	R:R:V104	46.8238	7.87	No	No	0	7	4
16	R:R:V104	R:R:Y102	43.167	11.36	No	No	0	4	4
17	R:R:P27	R:R:Y102	41.3181	6.95	No	No	0	8	4
18	R:R:P27	R:R:Y29	39.4668	6.95	No	Yes	0	8	4
19	R:R:F37	R:R:Y29	33.8973	5.16	No	Yes	0	5	4
20	R:R:A32	R:R:F37	13.2797	4.16	No	No	0	3	5
21	R:R:A32	R:R:Q36	11.3901	4.55	No	Yes	0	3	2
22	R:R:F37	R:R:M183	18.9333	6.22	No	No	0	5	2
23	R:R:L40	R:R:M183	17.0513	7.07	No	No	0	5	2
24	R:R:C185	R:R:L40	11.3901	3.17	No	No	0	5	5
25	R:R:Y191	R:R:Y192	90.8668	16.88	Yes	Yes	1	6	5
26	R:R:Y191	W:W:?3	90.293	5.64	Yes	Yes	1	6	0
27	R:R:E122	W:W:?3	46.885	5.1	No	Yes	1	6	0
28	R:R:E122	R:R:H211	46.4987	3.69	No	Yes	1	6	6
29	R:R:H211	R:R:W126	100	9.52	Yes	Yes	0	6	5
30	R:R:L125	R:R:W126	96.1901	5.69	No	Yes	0	7	5
31	R:R:L125	R:R:W265	22.7202	14.81	No	No	2	7	8
32	R:R:C264	R:R:W265	22.3874	11.75	No	No	2	8	8
33	R:R:C264	R:R:Y301	20.6521	4.03	No	Yes	2	8	5
34	R:R:T297	R:R:Y301	23.5235	4.99	No	Yes	2	6	5
35	R:R:L47	R:R:T297	13.3511	4.42	No	No	2	7	6
36	R:R:M207	W:W:?3	47.6501	6.8	Yes	Yes	1	5	0
37	R:R:H211	R:R:M207	53.8099	3.94	Yes	Yes	1	6	5
38	R:R:F91	R:R:L47	12.8309	12.18	Yes	No	0	7	7
39	R:R:F261	R:R:L125	73.0326	4.87	Yes	No	2	9	7
40	R:R:F261	R:R:L128	70.2275	3.65	Yes	No	0	9	8
41	R:R:L128	R:R:Y306	69.7659	14.07	No	Yes	0	8	9
42	R:R:L79	R:R:Y306	29.4232	3.52	No	Yes	0	9	9
43	R:R:D83	R:R:L79	28.6951	4.07	No	No	0	9	9
44	R:R:D83	R:R:N55	27.2313	12.12	No	Yes	0	9	9
45	R:R:A80	R:R:N55	22.7789	3.13	No	Yes	0	9	9
46	R:R:A80	R:R:T58	18.2346	3.36	No	No	0	9	9
47	R:R:I307	R:R:T58	17.4683	10.64	No	No	0	7	9
48	R:R:F313	R:R:I307	15.928	11.3	Yes	No	0	8	7
49	R:R:E134	R:R:F148	11.209	12.83	No	Yes	0	8	7
50	R:R:E134	R:R:I75	11.9575	4.1	No	Yes	3	8	7
51	R:R:I75	R:R:L131	23.4929	4.28	Yes	No	0	7	9
52	R:R:L131	R:R:R135	24.2388	17.01	No	No	0	9	9
53	R:R:R135	R:R:Y223	24.9821	6.17	No	Yes	0	9	9
54	R:R:M257	R:R:Y223	45.3333	11.97	No	Yes	0	8	9
55	R:R:M257	R:R:Y306	48.6484	11.97	No	Yes	0	8	9
56	R:R:V254	R:R:Y223	15.1196	3.79	No	Yes	0	8	9
57	R:R:V227	R:R:V254	14.3393	4.81	No	No	0	5	8
58	R:R:K231	R:R:V227	13.5602	4.55	No	No	0	5	5
59	R:R:E247	R:R:K231	11.9766	10.8	Yes	No	7	7	5
60	R:R:I179	R:R:Y192	85.9718	4.84	Yes	Yes	1	1	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C167	R:R:E122	9.12	1	No	No	5	6	2	1
R:R:E122	R:R:H211	3.69	1	No	Yes	6	6	1	2
R:R:E122	W:W:?3	5.1	1	No	Yes	6	0	1	0
R:R:C167	R:R:M207	4.86	1	No	Yes	5	5	2	1
R:R:C167	R:R:H211	8.85	1	No	Yes	5	6	2	2
R:R:Y191	R:R:Y192	16.88	1	Yes	Yes	6	5	1	2
R:R:Y191	R:R:Y268	5.96	1	Yes	Yes	6	6	1	1
R:R:A272	R:R:Y191	5.34	1	No	Yes	5	6	1	1
R:R:I275	R:R:Y191	6.04	1	No	Yes	4	6	2	1
R:R:Y191	W:W:?3	5.64	1	Yes	Yes	6	0	1	0
R:R:F203	R:R:M207	8.71	1	Yes	Yes	6	5	2	1
R:R:H211	R:R:M207	3.94	1	Yes	Yes	6	5	2	1
R:R:M207	W:W:?3	6.8	1	Yes	Yes	5	0	1	0
R:R:F208	R:R:F212	5.36	1	No	Yes	5	8	1	1
R:R:F208	R:R:I213	7.54	1	No	No	5	4	1	2
R:R:F208	W:W:?3	3.52	1	No	Yes	5	0	1	0
R:R:F212	R:R:I213	3.77	1	Yes	No	8	4	1	2
R:R:A269	R:R:F212	8.32	1	No	Yes	7	8	1	1
R:R:F212	W:W:?3	14.07	1	Yes	Yes	8	0	1	0
R:R:P291	R:R:Y268	6.95	0	No	Yes	6	6	2	1
R:R:Y268	W:W:?3	9.03	1	Yes	Yes	6	0	1	0
R:R:A269	W:W:?3	4.55	1	No	Yes	7	0	1	0
R:R:A272	W:W:?3	4.55	1	No	Yes	5	0	1	0
R:R:A269	R:R:G270	1.95	1	No	No	7	5	1	2
R:R:A295	R:R:Y268	1.33	0	No	Yes	8	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6PGS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	316
Number of Links	365
Number of Hubs	50
Number of Links mediated by Hubs	190
Number of Communities	7
Number of Nodes involved in Communities	84
Number of Links involved in Communities	129

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	120763
Length Of Smallest Path	3
Average Path Length	18.5136
Length of Longest Path	40
Minimum Path Strength	1.455
Average Path Strength	7.05195
Maximum Path Strength	35.55
Minimum Path Correlation	0.7
Average Path Correlation	0.947788
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	52.6992
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.537
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • multicellular organismal process • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • retina homeostasis • homeostasis of number of retina cells • detection of light stimulus involved in visual perception • detection of light stimulus • response to light stimulus • detection of external stimulus • sensory perception of light stimulus
Gene Ontology	Biological Process	• multicellular organismal process • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • retina homeostasis • homeostasis of number of retina cells • detection of light stimulus involved in visual perception • detection of light stimulus • response to light stimulus • detection of external stimulus • sensory perception of light stimulus • system process • nervous system process • response to stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of light stimulus involved in sensory perception • response to abiotic stimulus • response to radiation • visual perception • detection of stimulus involved in sensory perception • localization • macromolecule localization • intracellular protein localization • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • visual behavior • tissue remodeling • developmental process • tissue regeneration • developmental growth • neural tissue regeneration • anatomical structure development • growth • regeneration • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • sensory perception of chemical stimulus • sensory perception of taste • response to chemical • detection of chemical stimulus • sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • dopamine metabolic process • metabolic process • catechol-containing compound metabolic process • biogenic amine metabolic process • pigmentation • response to light intensity • background adaptation • regulation of pigmentation • biosynthetic process • macromolecule metabolic process • gene expression • macromolecule biosynthetic process • anatomical structure morphogenesis • cell morphogenesis • response to UV • cellular developmental process • sensory organ development • photoreceptor cell differentiation • visual system development • retina development in camera-type eye • neural retina development • eye morphogenesis • multicellular organism development • neurogenesis • neuron differentiation • cell differentiation • eye photoreceptor cell differentiation • animal organ morphogenesis • sensory system development • system development • camera-type eye morphogenesis • eye development • animal organ development • nervous system development • camera-type eye photoreceptor cell differentiation • generation of neurons • retina morphogenesis in camera-type eye • sensory organ morphogenesis • camera-type eye development • retinal rod cell differentiation • cone retinal bipolar cell differentiation • retinal bipolar neuron differentiation • glutamatergic neuron differentiation • phototransduction • organic anion transport • nitrogen compound transport • carboxylic acid transport • transport • L-amino acid transport • establishment of localization • L-glutamate import • organic acid transport • amino acid transport • acidic amino acid transport • dicarboxylic acid transport • cell development • retinal cone cell differentiation • photoreceptor cell development • eye photoreceptor cell development • retinal cone cell development • neuron development • defense response • response to stress • reactive gliosis • inflammatory response • neuroinflammatory response • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • opsin binding • protein binding • binding • arrestin family protein binding • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • vitamin binding • retinal binding • isoprenoid binding • retinoid binding • lipid binding • 11-cis retinal binding • small molecule binding • G-protein alpha-subunit binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • cation binding • transition metal ion binding • zinc ion binding • ion binding • metal ion binding • identical protein binding • multicellular organismal process • rod bipolar cell differentiation • cellular developmental process • sensory organ development • retina development in camera-type eye • visual system development • neural retina development • neurogenesis • multicellular organism development • eye morphogenesis • neuron differentiation • cell differentiation • anatomical structure development • animal organ morphogenesis • sensory system development • system development • developmental process • camera-type eye morphogenesis • eye development • animal organ development • nervous system development • retinal bipolar neuron differentiation • glutamatergic neuron differentiation • generation of neurons • retina morphogenesis in camera-type eye • anatomical structure morphogenesis • sensory organ morphogenesis • camera-type eye development • cellular process • cellular response to stimulus • response to light stimulus • response to stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of cellular process • signaling • detection of abiotic stimulus • cell communication • signal transduction • detection of light stimulus • phototransduction • detection of external stimulus • regulation of biological process • biological regulation • detection of visible light • response to external stimulus • detection of stimulus • G protein-coupled receptor signaling pathway • G protein-coupled opsin signaling pathway • phototransduction, visible light • response to light intensity • podosome assembly • organelle assembly • protein-containing complex organization • membraneless organelle assembly • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • protein-containing complex assembly • cellular component organization or biogenesis • biosynthetic process • metabolic process • macromolecule metabolic process • gene expression • macromolecule biosynthetic process • multicellular organismal-level homeostasis • homeostatic process • anatomical structure homeostasis • tissue homeostasis • retina homeostasis • photoreceptor cell maintenance • absorption of visible light • light absorption • microtubule cytoskeleton organization • microtubule-based process • cytoskeleton organization • sensory perception of light stimulus • system process • sensory perception • nervous system process • visual perception • thermoception • sensory perception of temperature stimulus • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of temperature stimulus involved in thermoception • detection of temperature stimulus • detection of stimulus involved in sensory perception • taxis • thermotaxis • locomotion • cell-cell junction • anchoring junction • photoreceptor disc membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • receptor complex • sperm midpiece • 9+2 motile cilium • sperm flagellum • motile cilium • photoreceptor inner segment membrane • Golgi membrane • Golgi apparatus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • outer membrane • sperm head • sperm head plasma membrane • sperm plasma membrane • rod photoreceptor outer segment
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	64Z
PDB Residues	W:W:?3
Environment Details	Open EMBL-EBI Page
Code	64Z
Name	Geraniol
Synonyms	(2E)-3,7-dimethylocta-2,6-dien-1-ol
Identifier
Formula	C10 H18 O
Molecular Weight	154.249
SMILES
PubChem	637566
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	0
Total Bonds	28
Total Aromatic Bonds	0


Code	NAG
PDB Residues	H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	BMA
PDB Residues	H:H:?3
Environment Details	Open EMBL-EBI Page
Code	BMA
Name	beta-D-mannopyranose
Synonyms	beta-D-mannose; D-mannose; mannose
Identifier
Formula	C6 H12 O6
Molecular Weight	180.156
SMILES
PubChem	439680
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	5
Total Bonds	24
Total Aromatic Bonds	0


Code	PLM
PDB Residues	H:H:?4
Environment Details	Open EMBL-EBI Page
Code	PLM
Name	Palmitic Acid
Synonyms	Palmitinsäure
Identifier
Formula	C16 H32 O2
Molecular Weight	256.424
SMILES
PubChem	985
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P02699
Sequence	>6PGS_nogp_Chain_R M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H K K L R T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G Y F V F G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K P M S N F R F G E N H A I M G V A F T W V M A L A C A A P P L V G W S R Y I P E G M Q C S C G I D Y Y T P H E E T N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q Q E S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H Q G S D F G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q F R N C M V T T L C C G K N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8P13	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.2	2024-11-20	To be published
	8P13 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.2	2024-11-20	To be published
	8P15	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.9	2024-11-20	To be published
	8P15 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.9	2024-11-20	To be published
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	doi.org/10.1073/pnas.1718084115
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol		2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol		2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PEL (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol		3.19	2020-06-24	To be published
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.6	2006-09-02	doi.org/10.1002/anie.200600595
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4J4Q (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-		2.65	2013-10-30	doi.org/10.1002/anie.201302374
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	doi.org/10.1016/j.bpj.2010.08.003
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	doi.org/10.1016/j.cell.2017.07.002
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	doi.org/10.1016/j.jmb.2004.07.044
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	doi.org/10.1016/j.jmb.2004.08.090
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	doi.org/10.1016/j.jmb.2007.03.007
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OY9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4X1H (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-		2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	doi.org/10.1021/bi0155091
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	doi.org/10.1038/embor.2013.44
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	4BEY (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	doi.org/10.1038/nature06925
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	doi.org/10.1038/nature07063
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3DQB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	3PQR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.85	2011-03-09	doi.org/10.1038/nature09789
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	3	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	2X72 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3	2011-03-16	doi.org/10.1038/nature09795
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	doi.org/10.1038/nature14656
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Arrestin1 Finger Loop	2.75	2014-09-17	doi.org/10.1038/ncomms5801
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	5WKT (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	9EPP	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPP (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/β1/γ2	4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	6CMO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-		4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	5.8	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	7	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4.1	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	doi.org/10.1038/sdata.2016.21
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.8	2006-08-22	doi.org/10.1073/pnas.0601765103
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	doi.org/10.1073/pnas.0608022103
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	doi.org/10.1073/pnas.082666399
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	4A4M (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	-	2.7	2017-03-15	doi.org/10.1073/pnas.1617446114
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	doi.org/10.1073/pnas.1617446114
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	doi.org/10.1073/pnas.1902192116
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	doi.org/10.1074/jbc.C800040200
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	doi.org/10.1074/jbc.RA119.010089
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	doi.org/10.1107/S0907444908017162
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	doi.org/10.1107/S0907444908017162
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Go	3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	6FUF (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	doi.org/10.1126/science.289.5480.739
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2015-06-17	doi.org/10.1371/journal.pone.0126970
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.3	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.81	2016-08-10	doi.org/10.15252/embr.201642671
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	doi.org/10.1529/biophysj.107.108225
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gi1/β1/γ1	4.38	2019-07-10	doi.org/10.7554/eLife.46041
	6QNO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.38	2019-07-10	doi.org/10.7554/eLife.46041
	9EPR	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-	Gi1/β1/γ2	4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-		4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6NWE (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		2.71	2020-02-12	To be published
	8P12	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	3.21	2024-11-20	To be published
	8P12 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.21	2024-11-20	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6PGS_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.