psnGPCR

Code	PLM
Name	Palmitic Acid
Synonyms	Hexadecylic acid
Identifier	hexadecanoic acid
Formula	C16 H32 O2
Molecular Weight	256.424
SMILES	CCCCCCCCCCCCCCCC(=O)O
PubChem	135369651
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0
Networks	53

This ligand is also present in the following 53 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

1GZM

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.65

2003-11-20

10.1016/j.jmb.2004.08.090

A 2D representation of the interactions of PLM in 1GZM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F52	R:R:P53	4.33	0	No	No	6	4	2	1
H:H:?13	R:R:P53	5.7	0	Yes	No	0	4	0	1
R:R:I54	R:R:N55	4.25	6	Yes	Yes	8	9	1	2
R:R:I54	R:R:V300	4.61	6	Yes	No	8	7	1	2
R:R:I54	R:R:P303	6.77	6	Yes	No	8	9	1	2
H:H:?13	R:R:I54	4.95	0	Yes	Yes	0	8	0	1
R:R:N55	R:R:P303	6.52	6	Yes	No	9	9	2	2
R:R:L321	R:R:M317	4.24	0	No	No	6	6	1	2
H:H:?13	R:R:L321	6	0	Yes	No	0	6	0	1
H:H:?13	R:R:C322	11.01	0	Yes	No	0	4	0	1
R:R:G51	R:R:I54	3.53	0	No	Yes	8	8	2	1
H:H:?13	R:R:L50	2.4	0	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	6.01
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 1GZM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F52	R:R:P53	4.33	0	No	No	6	4	1	2
R:R:F52	R:R:F88	6.43	0	No	No	6	4	1	2
H:H:?14	R:R:F52	8.45	3	Yes	No	0	6	0	1
R:R:F56	R:R:Y60	6.19	3	No	No	4	3	1	1
H:H:?14	R:R:F56	9.51	3	Yes	No	0	4	0	1
R:R:L57	R:R:V61	4.47	0	No	No	6	7	1	2
H:H:?14	R:R:L57	6	3	Yes	No	0	6	0	1
R:R:Q64	R:R:Y60	5.64	3	No	No	5	3	2	1
H:H:?14	R:R:Y60	11.18	3	Yes	No	0	3	0	1
H:H:?14	R:R:C323	9.63	3	Yes	No	0	9	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.95
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

1HZX

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.8

2001-07-04

10.1021/bi0155091

A 2D representation of the interactions of PLM in 1HZX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F52	R:R:P53	4.33	No	No	6	4	2	1
H:H:?11	R:R:P53	4.27	Yes	No	0	4	0	1
R:R:L57	R:R:M317	5.65	No	No	6	6	1	2
H:H:?11	R:R:L57	3.6	Yes	No	0	6	0	1
R:R:L321	R:R:M317	4.24	No	No	6	6	1	2
H:H:?11	R:R:L321	7.2	Yes	No	0	6	0	1
H:H:?11	R:R:C322	11.01	Yes	No	0	4	0	1
H:H:?12	R:R:C323	9.63	No	No	0	9	1	2
H:H:?11	H:H:?12	4.16	Yes	No	0	0	0	1
R:R:L57	R:R:V61	2.98	No	No	6	7	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.05
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 1HZX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?11	R:R:P53	4.27	Yes	No	4	1	2
H:H:?11	R:R:L57	3.6	Yes	No	6	1	2
H:H:?11	R:R:L321	7.2	Yes	No	6	1	2
H:H:?11	R:R:C322	11.01	Yes	No	4	1	2
H:H:?12	R:R:C323	9.63	No	No	9	0	1
H:H:?11	H:H:?12	4.16	Yes	No	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	6.90
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

1L9H

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.6

2002-05-15

10.1073/pnas.082666399

A 2D representation of the interactions of PLM in 1L9H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F52	R:R:P53	7.22	No	No	6	4	2	1
H:H:?11	R:R:P53	4.27	Yes	No	0	4	0	1
H:H:?11	R:R:F56	4.22	Yes	No	0	4	0	1
R:R:L57	R:R:V61	4.47	No	No	6	7	1	2
R:R:L57	R:R:M317	5.65	No	No	6	6	1	2
H:H:?11	R:R:L57	4.8	Yes	No	0	6	0	1
R:R:L321	R:R:M317	5.65	No	No	6	6	1	2
H:H:?11	R:R:L321	9.6	Yes	No	0	6	0	1
H:H:?11	R:R:C322	9.63	Yes	No	0	4	0	1
H:H:?12	R:R:C323	9.63	No	No	0	9	1	2
H:H:?11	H:H:?12	6.25	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.46
Average Nodes In Shell	11.00
Average Hubs In Shell	1.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 1L9H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	R:R:P53	4.27	Yes	No	0	4	1	2
H:H:?11	R:R:F56	4.22	Yes	No	0	4	1	2
H:H:?11	R:R:L57	4.8	Yes	No	0	6	1	2
H:H:?11	R:R:L321	9.6	Yes	No	0	6	1	2
H:H:?11	R:R:C322	9.63	Yes	No	0	4	1	2
H:H:?12	R:R:C323	9.63	No	No	0	9	0	1
H:H:?11	H:H:?12	6.25	Yes	No	0	0	1	0
R:R:C323	R:R:G324	1.96	No	No	9	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	7.94
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

1U19

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.2

2004-10-12

10.1016/j.jmb.2004.07.044

A 2D representation of the interactions of PLM in 1U19
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F52	R:R:P53	4.33	No	No	6	4	2	1
H:H:?11	R:R:P53	4.27	Yes	No	0	4	0	1
R:R:L321	R:R:M317	4.24	No	No	6	6	1	2
H:H:?11	R:R:L321	14.4	Yes	No	0	6	0	1
H:H:?11	R:R:C322	9.63	Yes	No	0	4	0	1
H:H:?12	R:R:C323	11.01	No	No	0	9	1	2
H:H:?11	H:H:?12	7.29	Yes	No	0	0	0	1
H:H:?11	R:R:V318	2.58	Yes	No	0	3	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	7.63
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 1U19
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	R:R:P53	4.27	Yes	No	0	4	1	2
H:H:?11	R:R:L321	14.4	Yes	No	0	6	1	2
H:H:?11	R:R:C322	9.63	Yes	No	0	4	1	2
H:H:?12	R:R:C323	11.01	No	No	0	9	0	1
H:H:?11	H:H:?12	7.29	Yes	No	0	0	1	0
H:H:?11	R:R:V318	2.58	Yes	No	0	3	1	2
R:R:C323	R:R:G324	1.96	No	No	9	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.15
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2G87

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

2.6

2006-09-02

10.1002/anie.200600595

A 2D representation of the interactions of PLM in 2G87
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F52	R:R:F56	4.29	No	No	6	4	2	1
H:H:?11	R:R:F56	5.28	Yes	No	0	4	0	1
R:R:L321	R:R:M317	4.24	No	No	6	6	1	2
H:H:?11	R:R:L321	12	Yes	No	0	6	0	1
H:H:?11	R:R:C322	9.63	Yes	No	0	4	0	1
H:H:?12	R:R:C323	9.63	No	No	0	9	1	2
H:H:?11	H:H:?12	6.25	Yes	No	0	0	0	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.29
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 2G87
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	R:R:F56	5.28	Yes	No	0	4	1	2
H:H:?11	R:R:L321	12	Yes	No	0	6	1	2
H:H:?11	R:R:C322	9.63	Yes	No	0	4	1	2
H:H:?12	R:R:C323	9.63	No	No	0	9	0	1
H:H:?11	H:H:?12	6.25	Yes	No	0	0	1	0
R:R:C323	R:R:G324	1.96	No	No	9	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	7.94
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2HPY

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

2.8

2006-08-22

10.1073/pnas.0601765103

A 2D representation of the interactions of PLM in 2HPY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	R:R:L57	4.8	No	No	0	6	0	1
H:H:?13	R:R:C322	11.01	No	No	0	4	0	1
H:H:?14	R:R:C323	9.63	No	No	0	9	1	2
H:H:?13	H:H:?14	15.61	No	No	0	0	0	1
R:R:L57	R:R:M317	2.83	No	No	6	6	1	2
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2
R:R:C322	R:R:N326	1.57	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.47
Average Nodes In Shell	8.00
Average Hubs In Shell	0.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 2HPY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	R:R:L57	4.8	No	No	0	6	1	2
H:H:?13	R:R:C322	11.01	No	No	0	4	1	2
H:H:?14	R:R:C323	9.63	No	No	0	9	0	1
H:H:?13	H:H:?14	15.61	No	No	0	0	1	0
R:R:C323	R:R:G324	1.96	No	No	9	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.62
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2I36

Sensory

Opsins

Rhodopsin

Bos taurus

4.1

2006-10-17

10.1073/pnas.0608022103

A 2D representation of the interactions of PLM in 2I36
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q64	R:R:T320	8.5	No	No	5	5	2	1
H:H:?16	R:R:T320	5.11	No	No	0	5	0	1
H:H:?16	R:R:C323	8.26	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.69
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2PED

Sensory

Opsins

Rhodopsin

Bos taurus

9-cis-Retinal

2.95

2007-10-30

10.1529/biophysj.107.108225

A 2D representation of the interactions of PLM in 2PED
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:M317	5.65	No	No	6	6	1	2
H:H:?13	R:R:C322	11.01	No	No	0	4	0	1
H:H:?14	R:R:C323	9.63	No	No	0	9	1	2
H:H:?13	H:H:?14	16.65	No	No	0	0	0	1
H:H:?13	R:R:L321	2.4	No	No	0	6	0	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.02
Average Nodes In Shell	7.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 2PED
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	R:R:C322	11.01	No	No	0	4	1	2
H:H:?14	R:R:C323	9.63	No	No	0	9	0	1
H:H:?13	H:H:?14	16.65	No	No	0	0	1	0
H:H:?13	R:R:L321	2.4	No	No	0	6	1	2
R:R:C323	R:R:G324	1.96	No	No	9	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.14
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2RH1

Amine

Adrenergic

Beta2

Homo sapiens

(S)-Carazolol

2.4

2007-10-30

10.1126/science.1150577

A 2D representation of the interactions of PLM in 2RH1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:C341	9.63	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.63
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2X72

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Gt(CT)

2011-03-16

10.1038/nature09795

A 2D representation of the interactions of PLM in 2X72
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:L321	4.8	No	No	6	1	2
H:H:?7	R:R:C322	9.63	No	No	4	1	2
H:H:?6	R:R:C323	9.63	No	No	9	0	1
H:H:?6	H:H:?7	19.78	No	No	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.71
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 2X72
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	4.15	No	No	6	6	1	2
H:H:?7	R:R:L321	4.8	No	No	0	6	0	1
H:H:?7	R:R:C322	9.63	No	No	0	4	0	1
H:H:?6	R:R:C323	9.63	No	No	0	9	1	2
H:H:?6	H:H:?7	19.78	No	No	0	0	1	0
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.40
Average Nodes In Shell	7.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2Z73

Sensory

Opsins

Rhodopsin

Todarodes pacificus

11-cis-Retinal

2.5

2008-05-13

10.1038/nature06925

A 2D representation of the interactions of PLM in 2Z73
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I309	R:R:I47	5.89	9	Yes	No	7	6	2	2
H:H:?1	R:R:M313	7.36	0	Yes	No	0	6	0	1
H:H:?1	R:R:S316	6.51	0	Yes	No	0	7	0	1
H:H:?1	R:R:V317	5.17	0	Yes	No	0	5	0	1
H:H:?1	R:R:C337	8.26	0	Yes	No	0	9	0	1
R:R:I47	R:R:M313	2.92	9	No	No	6	6	2	1
R:R:I309	R:R:M313	2.92	9	Yes	No	7	6	2	1
R:R:C336	R:R:C337	1.82	0	No	No	4	9	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.82
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2ZIY

Sensory

Opsins

Rhodopsin

Todarodes pacificus

11-cis-Retinal

3.7

2008-05-06

10.1074/jbc.C800040200

A 2D representation of the interactions of PLM in 2ZIY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I43	R:R:I47	4.42	No	Yes	4	6	1	2
H:H:?1	R:R:I43	3.71	No	No	0	4	0	1
H:H:?2	R:R:V317	3.88	No	No	0	5	1	2
H:H:?1	R:R:C336	9.63	No	No	0	4	0	1
H:H:?2	R:R:C337	9.63	No	No	0	9	1	2
H:H:?1	H:H:?2	7.29	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.88
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 2ZIY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:I43	3.71	No	No	0	4	1	2
H:H:?2	R:R:V317	3.88	No	No	0	5	0	1
R:R:C337	R:R:L334	6.35	No	No	9	1	1	2
H:H:?1	R:R:C336	9.63	No	No	0	4	1	2
H:H:?2	R:R:C337	9.63	No	No	0	9	0	1
H:H:?1	H:H:?2	7.29	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.93
Average Nodes In Shell	7.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3C9L

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.65

2008-08-05

10.1107/S0907444908017162

A 2D representation of the interactions of PLM in 3C9L
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F52	R:R:P53	4.33	0	No	No	6	4	2	1
H:H:?7	R:R:P53	5.7	0	Yes	No	0	4	0	1
R:R:I54	R:R:N55	4.25	6	Yes	Yes	8	9	1	2
R:R:I54	R:R:V300	4.61	6	Yes	No	8	7	1	2
R:R:I54	R:R:P303	8.47	6	Yes	No	8	9	1	2
H:H:?7	R:R:I54	4.95	0	Yes	Yes	0	8	0	1
R:R:N55	R:R:P303	6.52	6	Yes	No	9	9	2	2
H:H:?7	R:R:L321	6	0	Yes	No	0	6	0	1
H:H:?7	R:R:C322	11.01	0	Yes	No	0	4	0	1
R:R:G51	R:R:I54	3.53	0	No	Yes	8	8	2	1
H:H:?7	R:R:L50	2.4	0	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	6.01
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 3C9L
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F52	R:R:P53	4.33	0	No	No	6	4	1	2
R:R:F52	R:R:F88	7.5	0	No	No	6	4	1	2
H:H:?8	R:R:F52	7.39	3	Yes	No	0	6	0	1
R:R:F56	R:R:Y60	6.19	3	No	No	4	3	1	1
H:H:?8	R:R:F56	7.39	3	Yes	No	0	4	0	1
R:R:L57	R:R:V61	4.47	0	No	Yes	6	7	1	2
H:H:?8	R:R:L57	6	3	Yes	No	0	6	0	1
R:R:Q64	R:R:Y60	5.64	3	No	No	5	3	2	1
H:H:?8	R:R:Y60	11.18	3	Yes	No	0	3	0	1
H:H:?8	R:R:C323	9.63	3	Yes	No	0	9	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.32
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3CAP

Sensory

Opsins

Rhodopsin

Bos taurus

2.9

2008-06-24

10.1038/nature07063

A 2D representation of the interactions of PLM in 3CAP
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	R:R:C322	9.63	No	No	0	4	0	1
R:R:C322	R:R:N326	3.15	No	No	4	3	1	2
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.63
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3CAP_poly

Sensory

Opsins

Rhodopsin

Bos taurus

2.9

2008-06-24

10.1038/nature07063

A 2D representation of the interactions of PLM in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C322	R:R:N326	3.15	0	No	No	4	3	1	2
H:H:?13	R:R:C322	9.63	4	Yes	No	0	4	0	1
S:S:F293	S:S:Y43	11.35	4	No	No	5	4	2	2
S:S:T297	S:S:Y43	4.99	4	Yes	No	6	4	1	2
S:S:I256	S:S:I305	4.42	4	No	Yes	5	8	1	1
H:H:?13	S:S:I256	4.95	4	Yes	No	0	5	0	1
S:S:C264	S:S:S298	3.44	4	No	No	8	9	2	2
S:S:C264	S:S:Y301	4.03	4	No	Yes	8	5	2	1
S:S:F293	S:S:T297	3.89	4	No	Yes	5	6	2	1
S:S:T297	S:S:Y301	3.75	4	Yes	Yes	6	5	1	1
H:H:?13	S:S:T297	7.67	4	Yes	Yes	0	6	0	1
S:S:S298	S:S:Y301	6.36	4	No	Yes	9	5	2	1
S:S:N302	S:S:S298	5.96	4	Yes	No	9	9	2	2
S:S:N302	S:S:Y301	4.65	4	Yes	Yes	9	5	2	1
H:H:?13	S:S:Y301	8.13	4	Yes	Yes	0	5	0	1
S:S:M308	S:S:V304	7.61	0	No	No	6	7	2	1
H:H:?13	S:S:V304	5.17	4	Yes	No	0	7	0	1
S:S:I305	S:S:Y306	4.84	4	Yes	Yes	8	9	1	2
H:H:?13	S:S:I305	3.71	4	Yes	Yes	0	8	0	1
H:H:?13	S:S:M309	9.81	4	Yes	No	0	7	0	1
R:R:C322	R:R:V318	1.71	0	No	No	4	3	1	2
S:S:A260	S:S:I305	1.62	0	No	Yes	7	8	2	1
S:S:I256	S:S:M253	1.46	4	No	No	5	8	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	7.01
Average Nodes In Shell	19.00
Average Hubs In Shell	6.00
Average Links In Shell	23.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F293	R:R:Y43	10.32	5	No	Yes	5	4	2	2
R:R:T297	R:R:Y43	4.99	5	Yes	Yes	6	4	1	2
R:R:I256	R:R:I305	4.42	0	No	Yes	5	8	1	2
H:H:?14	R:R:I256	8.66	5	Yes	No	0	5	0	1
R:R:C264	R:R:S298	5.16	5	No	No	8	9	2	2
R:R:C264	R:R:Y301	4.03	5	No	Yes	8	5	2	1
R:R:F293	R:R:T297	3.89	5	No	Yes	5	6	2	1
R:R:T297	R:R:Y301	3.75	5	Yes	Yes	6	5	1	1
H:H:?14	R:R:T297	3.83	5	Yes	Yes	0	6	0	1
R:R:S298	R:R:Y301	8.9	5	No	Yes	9	5	2	1
R:R:N302	R:R:S298	5.96	5	Yes	No	9	9	2	2
R:R:N302	R:R:Y301	4.65	5	Yes	Yes	9	5	2	1
H:H:?14	R:R:Y301	8.13	5	Yes	Yes	0	5	0	1
R:R:I305	R:R:M309	4.37	0	Yes	No	8	7	2	1
H:H:?14	R:R:M309	7.36	5	Yes	No	0	7	0	1
S:S:C322	S:S:N326	7.87	0	No	No	4	3	1	2
H:H:?14	S:S:C322	9.63	5	Yes	No	0	4	0	1
R:R:M309	R:R:R314	1.24	0	No	No	7	8	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	7.52
Average Nodes In Shell	14.00
Average Hubs In Shell	6.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3DQB

Sensory

Opsins

Rhodopsin

Bos taurus

Gt(CT)

3.2

2008-09-23

10.1038/nature07330

A 2D representation of the interactions of PLM in 3DQB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:L321	3.6	No	No	0	6	1	2
H:H:?7	R:R:C322	8.26	No	No	0	4	1	2
H:H:?6	R:R:C323	8.26	No	No	0	9	0	1
H:H:?6	H:H:?7	14.57	No	No	0	0	0	1
R:R:C323	R:R:G324	1.96	No	No	9	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.41
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 3DQB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?7	R:R:L321	3.6	No	No	0	6	0	1
H:H:?7	R:R:C322	8.26	No	No	0	4	0	1
H:H:?6	R:R:C323	8.26	No	No	0	9	1	2
H:H:?6	H:H:?7	14.57	No	No	0	0	1	0
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.81
Average Nodes In Shell	7.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3OAX

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.6

2011-01-19

10.1016/j.bpj.2010.08.003

A 2D representation of the interactions of PLM in 3OAX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F52	R:R:F56	6.43	0	No	No	6	4	2	1
R:R:L57	R:R:M317	5.65	10	No	No	6	6	1	2
R:R:L321	R:R:L57	5.54	10	No	No	6	6	1	1
H:H:?11	R:R:L57	4.8	10	Yes	No	0	6	0	1
H:H:?11	R:R:L321	9.6	10	Yes	No	0	6	0	1
H:H:?11	R:R:C322	9.63	10	Yes	No	0	4	0	1
H:H:?12	R:R:C323	9.63	0	No	No	0	9	1	2
H:H:?11	H:H:?12	5.2	10	Yes	No	0	0	0	1
H:H:?11	R:R:F56	3.17	10	Yes	No	0	4	0	1
R:R:C322	R:R:V318	1.71	0	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.48
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 3OAX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	10	No	No	6	6	2	2
H:H:?11	R:R:L57	4.8	10	Yes	No	0	6	1	2
H:H:?11	R:R:L321	9.6	10	Yes	No	0	6	1	2
H:H:?11	R:R:C322	9.63	10	Yes	No	0	4	1	2
H:H:?12	R:R:C323	9.63	0	No	No	0	9	0	1
H:H:?11	H:H:?12	5.2	10	Yes	No	0	0	1	0
H:H:?11	R:R:F56	3.17	10	Yes	No	0	4	1	2
R:R:C323	R:R:G324	1.96	0	No	No	9	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	7.42
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3PQR

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Gt(CT)

2.85

2011-03-09

10.1038/nature09789

A 2D representation of the interactions of PLM in 3PQR
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	R:R:C323	9.63	No	No	0	9	0	1
R:R:C323	R:R:G324	1.96	No	No	9	3	1	2
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2
R:R:C322	R:R:N326	1.57	No	No	4	3	1	2
H:H:?5	R:R:C322	1.38	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	5.51
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3PXO

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

2011-03-09

10.1038/nature09789

A 2D representation of the interactions of PLM in 3PXO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?6	R:R:C323	8.26	No	No	0	9	0	1
R:R:C323	R:R:G324	1.96	No	No	9	3	1	2
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2
H:H:?6	R:R:C322	1.38	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	4.82
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4A4M

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Gt(CT)

3.3

2012-01-25

10.1073/pnas.1114089108

A 2D representation of the interactions of PLM in 4A4M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:C323	9.63	No	No	0	9	0	1
H:H:?3	R:R:C322	2.75	No	No	0	4	0	1
R:R:C322	R:R:N326	1.57	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.19
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4BEY

Sensory

Opsins

Rhodopsin

Bos taurus

Gt(CT)

2.9

2013-05-08

10.1038/embor.2013.44

A 2D representation of the interactions of PLM in 4BEY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C323	9.63	0	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.63
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4BEZ

Sensory

Opsins

Rhodopsin

Bos taurus

3.3

2013-04-24

10.1038/embor.2013.44

A 2D representation of the interactions of PLM in 4BEZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C323	9.63	0	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.63
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4IB4

Amine

5-Hydroxytryptamine

5-HT2B

Homo sapiens

Ergotamine

2.7

2013-03-13

10.1126/science.1232808

A 2D representation of the interactions of PLM in 4IB4
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I61	R:R:I66	2.94	0	No	Yes	7	4	2	1
R:R:I66	R:R:L62	2.85	4	Yes	No	4	3	1	1
H:H:?1	R:R:L62	7.2	4	No	No	0	3	0	1
R:R:I66	R:R:P67	3.39	4	Yes	No	4	4	1	2
H:H:?1	R:R:I66	4.95	4	No	Yes	0	4	0	1
R:R:C397	R:R:Y399	8.06	0	No	No	8	4	1	2
H:H:?1	R:R:C397	9.63	4	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	7.26
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4J4Q

Sensory

Opsins

Rhodopsin

Bos taurus

Octyl Beta-D-Glucopyranoside

Gt(CT)

2.65

2013-10-30

10.1002/anie.201302374

A 2D representation of the interactions of PLM in 4J4Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C323	8.26	No	No	0	9	0	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2
H:H:?4	R:R:C322	1.38	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	4.82
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4NC3

Amine

5-Hydroxytryptamine

5-HT2B

Homo sapiens

Ergotamine

2.8

2013-12-18

10.1126/science.1244142

A 2D representation of the interactions of PLM in 4NC3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:L62	6	No	No	0	3	0	1
R:R:C397	R:R:Y399	5.38	No	No	8	4	1	2
H:H:?1	R:R:C397	9.63	No	No	0	8	0	1
R:R:I66	R:R:P67	3.39	No	No	4	4	1	2
H:H:?1	R:R:I66	2.48	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.04
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4PXF

Sensory

Opsins

Rhodopsin

Bos taurus

Octyl Beta-D-Glucopyranoside

Arrestin1_Finger_loop

2.75

2014-09-17

10.1038/ncomms5801

A 2D representation of the interactions of PLM in 4PXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C323	8.26	0	No	No	0	9	0	1
H:H:?4	R:R:C322	1.38	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	4.82
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4X1H

Sensory

Opsins

Rhodopsin

Bos taurus

Nonyl Beta-D-Glucopyranoside

Gt(CT)

2.29

2015-11-04

10.1016/j.str.2015.09.015

A 2D representation of the interactions of PLM in 4X1H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?6	R:R:C322	9.63	No	No	0	4	0	1
H:H:?7	R:R:C323	9.63	No	No	0	9	1	2
H:H:?6	H:H:?7	12.49	No	No	0	0	0	1
R:R:C322	R:R:K325	3.23	No	No	4	3	1	2
H:H:?6	R:R:L321	2.4	No	No	0	6	0	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.17
Average Nodes In Shell	8.00
Average Hubs In Shell	0.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 4X1H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?6	R:R:C322	9.63	No	No	4	1	2
H:H:?7	R:R:C323	9.63	No	No	9	0	1
H:H:?6	H:H:?7	12.49	No	No	0	1	0
H:H:?6	R:R:L321	2.4	No	No	6	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.06
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5D5A

Amine

Adrenergic

Beta2

Homo sapiens

(S)-Carazolol

2.48

2016-01-13

10.1107/S2059798315021683

A 2D representation of the interactions of PLM in 5D5A
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:C341	9.63	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.63
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5D5B

Amine

Adrenergic

Beta2

Homo sapiens

(S)-Carazolol

3.8

2016-01-13

10.1107/S2059798315021683

A 2D representation of the interactions of PLM in 5D5B
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:C341	12.39	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.39
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5D6L

Amine

Adrenergic

Beta2

Homo sapiens

(S)-Carazolol

3.2

2016-08-17

10.1038/nprot.2017.057

A 2D representation of the interactions of PLM in 5D6L
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:C341	9.63	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.63
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5DYS

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

2.3

2016-08-10

10.15252/embr.201642671

A 2D representation of the interactions of PLM in 5DYS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C322	9.63	No	No	0	4	0	1
H:H:?5	R:R:C323	9.63	No	No	0	9	1	2
H:H:?4	H:H:?5	10.41	No	No	0	0	0	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.02
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 5DYS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C322	9.63	No	No	4	1	2
H:H:?5	R:R:C323	9.63	No	No	9	0	1
H:H:?4	H:H:?5	10.41	No	No	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.02
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5EN0

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Gt(CT)

2.81

2016-08-10

10.15252/embr.201642671

A 2D representation of the interactions of PLM in 5EN0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?4	R:R:L321	4.8	No	No	0	6	0	1
H:H:?4	R:R:C322	9.63	No	No	0	4	0	1
H:H:?5	R:R:C323	9.63	No	No	0	9	1	2
H:H:?4	H:H:?5	8.33	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	7.59
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 5EN0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:L321	4.8	No	No	6	1	2
H:H:?4	R:R:C322	9.63	No	No	4	1	2
H:H:?5	R:R:C323	9.63	No	No	9	0	1
H:H:?4	H:H:?5	8.33	No	No	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.98
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5TE3

Sensory

Opsins

Rhodopsin

Bos taurus

Octyl Beta-D-Glucopyranoside

2.7

2017-03-15

10.1073/pnas.1617446114

A 2D representation of the interactions of PLM in 5TE3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C322	R:R:N326	6.3	No	No	4	3	1	2
H:H:?4	R:R:C322	9.63	No	No	0	4	0	1
H:H:?5	R:R:C323	11.01	No	No	0	9	1	2
H:H:?4	H:H:?5	11.45	No	No	0	0	0	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.54
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 5TE3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C322	9.63	No	No	4	1	2
H:H:?5	R:R:C323	11.01	No	No	9	0	1
H:H:?4	H:H:?5	11.45	No	No	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.23
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FK6

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473033

2.36

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of PLM in 6FK6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?4	R:R:C322	11.01	No	No	0	4	0	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2
H:H:?4	R:R:L321	1.2	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.10
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FK7

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473034

2.62

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of PLM in 6FK7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?6	R:R:C322	12.39	No	No	0	4	0	1
H:H:?6	R:R:V318	2.58	No	No	0	3	0	1
H:H:?6	R:R:L321	1.2	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	5.39
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FK8

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473035

2.87

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of PLM in 6FK8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?4	R:R:C322	12.39	No	No	0	4	0	1
H:H:?4	R:R:V318	1.29	No	No	0	3	0	1
H:H:?4	R:R:L321	1.2	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	4.96
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FK9

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473036

2.63

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of PLM in 6FK9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?6	R:R:C322	12.39	No	No	0	4	0	1
H:H:?6	R:R:V318	2.58	No	No	0	3	0	1
R:R:N326	R:R:V318	1.48	No	No	3	3	2	1
H:H:?6	R:R:L321	1.2	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	5.39
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FKA

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473037

2.7

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of PLM in 6FKA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?6	R:R:C322	12.39	0	No	No	0	4	0	1
R:R:C322	R:R:N326	3.15	0	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.39
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FKB

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473038

3.03

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of PLM in 6FKB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?1	R:R:C322	9.63	No	No	0	4	0	1
R:R:C322	R:R:K325	1.62	No	No	4	3	1	2
H:H:?1	R:R:L321	1.2	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	5.42
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FKC

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473039

2.46

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of PLM in 6FKC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?6	R:R:C322	11.01	No	No	0	4	0	1
R:R:C322	R:R:N326	3.15	No	No	4	3	1	2
H:H:?6	R:R:L321	1.2	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.10
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FKD

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 137349183

2.49

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of PLM in 6FKD
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?6	R:R:C322	12.39	0	No	No	0	4	0	1
H:H:?6	R:R:V318	1.29	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.84
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6NWE

Sensory

Opsins

Rhodopsin

Bos taurus

Octyl Beta-D-Glucopyranoside

Gt(CT)

2.71

2020-02-12

To be published

A 2D representation of the interactions of PLM in 6NWE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C323	8.26	0	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.26
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6PEL

Sensory

Opsins

Rhodopsin

Bos taurus

Citronellol

Gt(CT)

3.19

2020-06-24

To be published

A 2D representation of the interactions of PLM in 6PEL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C323	9.63	0	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.63
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6PGS

Sensory

Opsins

Rhodopsin

Bos taurus

Geraniol

Gt(CT)

2.9

2020-07-01

To be published

A 2D representation of the interactions of PLM in 6PGS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:C323	9.63	0	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.63
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7D76

Adhesion

ADGRG3

Homo sapiens

Beclomethasone

Go/Beta1/Gamma2

3.1

2021-02-03

10.1038/s41586-020-03083-w

A 2D representation of the interactions of PLM in 7D76
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:A305	R:R:H309	2.93	0	No	No	7	8	2	2
R:R:A305	R:R:H362	2.93	0	No	Yes	7	7	2	1
R:R:H362	R:R:I308	6.63	0	Yes	Yes	7	8	1	2
R:R:H309	R:R:W520	12.7	0	No	Yes	8	7	2	1
R:R:L312	R:R:M356	2.83	0	Yes	No	8	9	2	1
R:R:F353	R:R:Y438	3.09	1	Yes	Yes	8	8	2	2
R:R:F353	R:R:F439	6.43	1	Yes	Yes	8	6	2	1
R:R:F353	R:R:W490	8.02	1	Yes	Yes	8	9	2	2
R:R:F353	R:R:I494	5.02	1	Yes	Yes	8	5	2	2
R:R:M356	R:R:W490	8.14	0	No	Yes	9	9	1	2
H:H:?1	R:R:M356	6.13	1	Yes	No	0	9	0	1
R:R:A360	R:R:F445	2.77	0	No	No	8	5	1	2
H:H:?1	R:R:A360	5.47	1	Yes	No	0	8	0	1
R:R:H362	R:R:L366	9	0	Yes	No	7	6	1	2
R:R:H362	R:R:Y378	7.62	0	Yes	Yes	7	6	1	2
H:H:?1	R:R:H362	4.46	1	Yes	Yes	0	7	0	1
R:R:L363	R:R:L479	4.15	1	No	Yes	8	6	1	1
H:H:?1	R:R:L363	7.2	1	Yes	No	0	8	0	1
R:R:T442	R:R:Y438	2.5	0	No	Yes	7	8	1	2
R:R:F439	R:R:G491	4.52	1	Yes	No	6	6	1	2
R:R:F439	R:R:I494	3.77	1	Yes	Yes	6	5	1	2
H:H:?1	R:R:F439	3.17	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:T442	3.83	1	Yes	No	0	7	0	1
R:R:F443	R:R:M447	8.71	1	No	No	7	3	1	2
R:R:F443	R:R:G487	4.52	1	No	No	7	9	1	1
H:H:?1	R:R:F443	4.22	1	Yes	No	0	7	0	1
H:H:?1	R:R:G446	2.97	1	Yes	No	0	9	0	1
R:R:L450	R:R:L479	2.77	0	No	Yes	7	6	2	1
R:R:L450	R:R:S483	4.5	0	No	No	7	6	2	1
A:A:L353	R:R:L479	5.54	1	Yes	Yes	6	6	2	1
H:H:?1	R:R:L479	3.6	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:S483	11.72	1	Yes	No	0	6	0	1
H:H:?1	R:R:G487	2.97	1	Yes	No	0	9	0	1
R:R:F516	R:R:W520	4.01	0	No	Yes	6	7	2	1
R:R:L524	R:R:W520	6.83	0	No	Yes	6	7	2	1
H:H:?1	R:R:W520	3.95	1	Yes	Yes	0	7	0	1
A:A:C351	H:H:?1	11.01	0	No	Yes	4	0	1	0
R:R:A360	R:R:G357	1.95	0	No	No	8	6	1	2

Statistics	Value
Average Number Of Links	13.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	5.44
Average Nodes In Shell	32.00
Average Hubs In Shell	13.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	32.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7D77

Adhesion

ADGRG3

Homo sapiens

Hydrocortisone

Go/Beta1/Gamma2

2.9

2021-02-03

10.1038/s41586-020-03083-w

A 2D representation of the interactions of PLM in 7D77
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H362	R:R:I308	5.3	0	Yes	No	7	8	1	2
R:R:E359	R:R:H309	9.85	0	No	Yes	9	8	2	1
R:R:H309	R:R:W520	7.41	0	Yes	No	8	7	1	2
R:R:H309	R:R:Y525	5.44	0	Yes	Yes	8	6	1	2
H:H:?1	R:R:H309	5.57	0	Yes	Yes	0	8	0	1
R:R:F353	R:R:Y438	4.13	15	Yes	Yes	8	8	2	2
R:R:F353	R:R:F439	8.57	15	Yes	Yes	8	6	2	1
R:R:F353	R:R:W490	6.01	15	Yes	Yes	8	9	2	2
R:R:F353	R:R:I494	5.02	15	Yes	Yes	8	5	2	2
R:R:M356	R:R:W490	5.82	0	No	Yes	9	9	1	2
H:H:?1	R:R:M356	4.9	0	Yes	No	0	9	0	1
R:R:A360	R:R:V449	3.39	0	No	No	8	7	1	2
H:H:?1	R:R:A360	4.1	0	Yes	No	0	8	0	1
R:R:H362	R:R:L366	9	0	Yes	No	7	6	1	2
R:R:H362	R:R:Y378	7.62	0	Yes	Yes	7	6	1	2
H:H:?1	R:R:H362	4.46	0	Yes	Yes	0	7	0	1
R:R:L363	R:R:L479	5.54	0	No	No	8	6	1	2
H:H:?1	R:R:L363	8.4	0	Yes	No	0	8	0	1
R:R:T442	R:R:Y438	3.75	0	No	Yes	7	8	1	2
R:R:F439	R:R:G491	4.52	15	Yes	No	6	6	1	2
R:R:F439	R:R:I494	6.28	15	Yes	Yes	6	5	1	2
H:H:?1	R:R:F439	6.34	0	Yes	Yes	0	6	0	1
H:H:?1	R:R:T442	3.83	0	Yes	No	0	7	0	1
R:R:F443	R:R:M447	8.71	0	No	No	7	3	1	2
R:R:F443	R:R:G487	4.52	0	No	No	7	9	1	2
H:H:?1	R:R:F443	3.17	0	Yes	No	0	7	0	1
R:R:L450	R:R:S483	6.01	0	No	No	7	6	2	1
H:H:?1	R:R:S483	7.81	0	Yes	No	0	6	0	1
A:A:C351	H:H:?1	11.01	0	No	Yes	4	0	1	0
R:R:L363	R:R:V453	2.98	0	No	No	8	7	1	2
R:R:A305	R:R:H309	2.93	0	No	Yes	7	8	2	1
R:R:A305	R:R:H362	2.93	0	No	Yes	7	7	2	1
R:R:G357	R:R:T442	1.82	0	No	No	6	7	2	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	5.96
Average Nodes In Shell	30.00
Average Hubs In Shell	10.00
Average Links In Shell	33.00
Average Links Mediated by Hubs In Shell	26.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7ZBC

Sensory

Opsins

Rhodopsin

Bos Taurus

11-cis-Retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of PLM in 7ZBC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L46	R:R:L50	8.3	No	No	5	5	2	1
H:H:?410	R:R:L50	3.6	No	No	0	5	0	1
H:H:?410	R:R:C322	9.63	No	No	0	4	0	1
R:R:L321	R:R:L57	2.77	No	No	6	6	1	2
H:H:?410	R:R:L321	2.4	No	No	0	6	0	1
R:R:G51	R:R:L50	1.71	No	No	8	5	2	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	5.21
Average Nodes In Shell	8.00
Average Hubs In Shell	0.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7ZBE

Sensory

Opsins

Rhodopsin

Bos Taurus

11-cis-Retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of PLM in 7ZBE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?410	R:R:C322	8.26	No	No	0	4	0	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2
R:R:C322	R:R:L321	1.59	No	No	4	6	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.26
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8A6C

Sensory

Opsins

Rhodopsin

Bos Taurus

All-trans-retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of PLM in 8A6C
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?410	R:R:C322	8.26	0	No	No	0	4	0	1
R:R:C322	R:R:V318	1.71	0	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.26
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8A6D

Sensory

Opsins

Rhodopsin

Bos Taurus

All-trans-retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of PLM in 8A6D
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?410	R:R:C322	8.26	0	No	No	0	4	0	1
R:R:C322	R:R:L321	1.59	0	No	No	4	6	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.26
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8A6E

Sensory

Opsins

Rhodopsin

Bos Taurus

All-trans-retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of PLM in 8A6E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L321	R:R:L57	5.54	No	No	6	6	1	2
H:H:?406	R:R:L321	4.8	No	No	0	6	0	1
H:H:?406	R:R:C322	8.26	No	No	0	4	0	1
R:R:C322	R:R:V318	1.71	No	No	4	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.53
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8U8F

Orphan

A orphans

GPR3

Homo sapiens

PML

Gs/Beta1/Gamma2

3.49

2024-03-06

10.1021/acs.biochem.3c00647

A 2D representation of the interactions of PLM in 8U8F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P189	R:R:V113	10.6	1	Yes	No	2	5	2	2
R:R:L190	R:R:V113	4.47	1	Yes	No	3	5	1	2
R:R:A164	R:R:T121	3.36	0	No	No	8	6	2	1
R:R:L167	R:R:T121	5.9	0	No	No	4	6	2	1
L:L:?1	R:R:T121	5.11	1	Yes	No	0	6	0	1
R:R:I124	R:R:V205	4.61	1	No	No	7	7	1	1
R:R:I124	R:R:W260	9.4	1	No	Yes	7	8	1	2
L:L:?1	R:R:I124	11.14	1	Yes	No	0	7	0	1
R:R:G125	R:R:V160	3.68	0	No	No	4	6	1	2
L:L:?1	R:R:G125	2.97	1	Yes	No	0	4	0	1
R:R:L128	R:R:V205	5.96	0	No	No	7	7	2	1
R:R:L167	R:R:L198	5.54	0	No	No	4	6	2	1
R:R:P189	R:R:V187	3.53	1	Yes	Yes	2	4	2	1
R:R:L190	R:R:V187	2.98	1	Yes	Yes	3	4	1	1
R:R:L195	R:R:V187	2.98	0	No	Yes	4	4	2	1
L:L:?1	R:R:V187	5.17	1	Yes	Yes	0	4	0	1
R:R:L190	R:R:P189	4.93	1	Yes	Yes	3	2	1	2
L:L:?1	R:R:L190	6	1	Yes	Yes	0	3	0	1
R:R:H194	R:R:L198	12.86	0	Yes	No	6	6	2	1
R:R:C267	R:R:L195	7.94	0	No	No	5	4	2	2
L:L:?1	R:R:L198	10.8	1	Yes	No	0	6	0	1
R:R:F202	R:R:F203	5.36	1	Yes	No	7	5	1	2
R:R:F202	R:R:F256	6.43	1	Yes	Yes	7	8	1	2
R:R:F202	R:R:W260	9.02	1	Yes	Yes	7	8	1	2
R:R:F202	R:R:T264	15.56	1	Yes	No	7	6	1	2
L:L:?1	R:R:F202	6.34	1	Yes	Yes	0	7	0	1
R:R:F203	R:R:T264	7.78	1	No	No	5	6	2	2
L:L:?1	R:R:V205	3.88	1	Yes	No	0	7	0	1
R:R:F256	R:R:W260	6.01	1	Yes	Yes	8	8	2	2
R:R:C267	R:R:F263	8.38	0	No	No	5	5	2	1
L:L:?1	R:R:F263	4.22	1	Yes	No	0	5	0	1
L:L:?1	R:R:A201	2.73	1	Yes	No	0	4	0	1
R:R:F202	R:R:L261	2.44	1	Yes	No	7	4	1	2
R:R:F203	R:R:L261	2.44	1	No	No	5	4	2	2

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	5.84
Average Nodes In Shell	25.00
Average Hubs In Shell	8.00
Average Links In Shell	34.00
Average Links Mediated by Hubs In Shell	24.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9AUC

Peptide

Calcitonin

Homo Sapiens

Calcitonin gene-related peptide-1

Gs/Beta1/Gamma2; RAMP1

2.4

2024-04-24

10.1021/acs.biochem.4c00114

A 2D representation of the interactions of PLM in 9AUC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:G21	L:L:K24	3.49	0	No	No	0	0	2	1
L:L:V23	R:R:Y146	10.09	0	No	No	0	2	2	1
L:L:?101	L:L:K24	12.23	20	Yes	No	0	0	0	1
H:H:?1	L:L:K24	3.67	20	Yes	No	0	0	1	1
R:R:Y146	R:R:Y150	3.97	20	No	Yes	2	4	1	1
L:L:?101	R:R:Y146	11.18	20	Yes	No	0	2	0	1
R:R:Y149	R:R:Y150	11.91	0	Yes	Yes	5	4	2	1
R:R:I153	R:R:Y149	8.46	0	No	Yes	7	5	2	2
L:L:?101	R:R:Y150	10.17	20	Yes	Yes	0	4	0	1
H:H:?1	R:R:Y150	7.12	20	Yes	Yes	0	4	1	1
R:R:L151	R:R:S378	6.01	0	No	No	5	5	1	2
R:R:F382	R:R:L151	3.65	0	No	No	7	5	2	1
L:L:?101	R:R:L151	3.6	20	Yes	No	0	5	0	1
H:H:?1	R:R:I153	4.95	20	Yes	No	0	7	1	2
L:L:?101	R:R:V154	3.88	20	Yes	No	0	6	0	1
H:H:?1	R:R:S157	9.11	20	Yes	No	0	7	1	2
H:H:?1	L:L:?101	5.2	20	Yes	Yes	0	0	1	0

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	7.71
Average Nodes In Shell	14.00
Average Hubs In Shell	4.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of PLM in 9AUC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:G21	L:L:K24	3.49	0	No	No	0	0	2	1
L:L:?101	L:L:K24	12.23	20	Yes	No	0	0	1	1
H:H:?1	L:L:K24	3.67	20	Yes	No	0	0	0	1
R:R:Y146	R:R:Y150	3.97	20	No	Yes	2	4	2	1
L:L:?101	R:R:Y146	11.18	20	Yes	No	0	2	1	2
R:R:Y149	R:R:Y150	11.91	0	Yes	Yes	5	4	2	1
R:R:I153	R:R:Y149	8.46	0	No	Yes	7	5	1	2
L:L:?101	R:R:Y150	10.17	20	Yes	Yes	0	4	1	1
H:H:?1	R:R:Y150	7.12	20	Yes	Yes	0	4	0	1
L:L:?101	R:R:L151	3.6	20	Yes	No	0	5	1	2
H:H:?1	R:R:I153	4.95	20	Yes	No	0	7	0	1
L:L:?101	R:R:V154	3.88	20	Yes	No	0	6	1	2
H:H:?1	R:R:S157	9.11	20	Yes	No	0	7	0	1
H:H:?1	L:L:?101	5.2	20	Yes	Yes	0	0	0	1
R:R:I199	R:R:S157	3.1	0	No	No	7	7	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	6.01
Average Nodes In Shell	12.00
Average Hubs In Shell	4.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.38
Average Interaction Strength	8.07
Average Nodes In Shell	7.25
Average Hubs In Shell	1.04
Average Links In Shell	6.94
Average Links Mediated by Hubs In Shell	3.27

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)