Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N23 6.1275427
2A:A:E209 5.0125459
3A:A:F219 6.3025408
4A:A:F222 11.626557
5A:A:R232 7.395498
6A:A:K233 7.32599
7A:A:W234 9.1475409
8A:A:F238 8.36459
9A:A:I244 5.9375458
10A:A:F246 4.025409
11A:A:S251 5.2975409
12A:A:Y253 5.325408
13A:A:L270 3.9225406
14A:A:F273 8.6125469
15A:A:W277 10.8875466
16A:A:W281 12.8554155
17A:A:L282 5.28409
18A:A:L289 5.444569
19A:A:L297 3.125408
20A:A:Y311 8.0925406
21A:A:F312 4.45168
22A:A:F315 7.7406
23A:A:F340 8.385167
24A:A:R342 5.614564
25A:A:F345 6.22568
26A:A:L346 3.966564
27A:A:S349 5.545467
28A:A:R356 8.5454172
29A:A:Y358 7.53434
30A:A:C359 4.215465
31A:A:Y360 7.83667638
32A:A:F363 7.445465
33A:A:F376 4.83638
34A:A:R380 6.2075437
35A:A:R385 10.076535
36A:A:L388 4.706538
37B:B:I18 3.675407
38B:B:I37 4.00754142
39B:B:V40 4.4585143
40B:B:L51 8.8825429
41B:B:R52 6.175407
42B:B:H54 5.57167629
43B:B:W63 5.3525407
44B:B:R68 9.2325425
45B:B:L70 5.8625425
46B:B:S72 4.82529
47B:B:Q75 10.275459
48B:B:D76 7.1475409
49B:B:K78 6.785408
50B:B:L79 4.0175407
51B:B:I80 7.055428
52B:B:W82 9.37629
53B:B:T86 7.5425426
54B:B:N88 9.445427
55B:B:K89 7.35529
56B:B:I93 5.4325407
57B:B:L95 4.088508
58B:B:W99 8.7659
59B:B:Y105 4.38626
60B:B:Y124 4.46506
61B:B:L126 4.185425
62B:B:T128 3.7025403
63B:B:L139 4.1775409
64B:B:Y145 5.328598
65B:B:F151 8.2425409
66B:B:N155 4.744193
67B:B:V158 3.35254185
68B:B:T159 5.625129
69B:B:C166 4.076588
70B:B:W169 8.7485128
71B:B:F180 6.396587
72B:B:H183 9.204589
73B:B:D186 4.745499
74B:B:L190 4.8675405
75B:B:F199 7.0225489
76B:B:S201 5.0125489
77B:B:C204 6.4675497
78B:B:D205 6.785409
79B:B:K209 10.754586
80B:B:L210 5.14405
81B:B:W211 7.09833688
82B:B:E215 6.42754203
83B:B:F222 7.005478
84B:B:H225 6.82857779
85B:B:D228 7.062599
86B:B:I232 3.76408
87B:B:F234 6.09405
88B:B:F235 8.625717116
89B:B:N237 7.6385115
90B:B:F241 7.86576
91B:B:D247 8.715479
92B:B:R251 11.18578
93B:B:F253 6.21143776
94B:B:D254 5.6275409
95B:B:R256 9.625409
96B:B:Q259 4.705406
97B:B:M262 7.61404
98B:B:Y264 6.8425405
99B:B:F278 6.533336117
100B:B:K280 7.97441
101B:B:R283 8.39754149
102B:B:L285 6.284116
103B:B:Y289 8.376676137
104B:B:D290 5.6654156
105B:B:N293 5.254135
106B:B:N295 9.82254136
107B:B:V307 5.1354133
108B:B:L308 7.25407
109B:B:H311 7.633336109
110B:B:R314 16.48754158
111B:B:T321 6.484547
112B:B:G324 3.08449
113B:B:M325 5.24545
114B:B:T329 5.394108
115B:B:W332 13.1409
116B:B:L336 6.6825427
117B:B:K337 10.8754106
118B:B:W339 7.6665109
119G:G:I9 2.1325402
120G:G:L19 4.19409
121G:G:R27 7.005408
122G:G:Y40 10.17754116
123G:G:D48 6.632549
124G:G:V54 5.64446
125G:G:N59 6.145449
126G:G:P60 7.185449
127G:G:F61 6.742508
128L:L:?1 5.8671010
129R:R:P40 4.9875403
130R:R:V54 3.975407
131R:R:N58 8.6375419
132R:R:F71 6.6825408
133R:R:L82 5.19167619
134R:R:D86 8.386519
135R:R:L112 3.475405
136R:R:L127 7.0225418
137R:R:R134 10.09419
138R:R:L142 4.8325437
139R:R:T153 4.32754216
140R:R:W161 4.232509
141R:R:V187 3.67415
142R:R:P189 4.974513
143R:R:L190 4.6025413
144R:R:H194 9.235407
145R:R:F202 7.53618
146R:R:Y213 6.11714719
147R:R:H223 8.364537
148R:R:R243 3.085405
149R:R:F256 6.2625419
150R:R:W260 8.7618
151R:R:Y266 5.936503
152R:R:Y280 5.705404
153R:R:N289 8.068519
154R:R:M291 4.36405
155R:R:N293 9.555419
156R:R:Y297 6.96519
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I80 B:B:K78 41.74228.72YesYes088
2A:A:D33 B:B:K78 20.81311.06NoYes058
3A:A:D33 B:B:L55 20.80479.5NoNo056
4A:A:K34 B:B:L55 1008.46NoNo046
5B:B:D76 B:B:K78 20.93974.15YesYes098
6B:B:D76 B:B:L55 79.28429.5YesNo096
7A:A:K34 A:A:R38 99.55663.71NoNo044
8A:A:R38 R:R:E147 99.37913.96NoNo045
9R:R:E147 R:R:V150 99.29058.56NoNo053
10R:R:V150 R:R:Y154 99.02396.31NoNo031
11R:R:L77 R:R:Y154 98.9354.69NoNo041
12R:R:L77 R:R:T153 98.75714.42NoYes046
13R:R:L157 R:R:T153 98.12092.95NoYes2176
14R:R:L157 R:R:S81 98.04443NoNo079
15R:R:S126 R:R:S81 97.50884.89NoNo089
16R:R:L82 R:R:S126 97.41946.01YesNo098
17R:R:L127 R:R:L82 41.11926.92YesYes189
18R:R:L127 R:R:Y297 16.45824.69YesYes189
19R:R:R134 R:R:Y297 25.60778.23YesYes199
20A:A:Y391 R:R:R134 25.021718.52NoYes049
21A:A:H387 A:A:Y391 24.38313.27NoNo084
22A:A:H387 A:A:I383 23.95983.98NoNo088
23A:A:I383 A:A:T242 23.53483.04NoNo088
24A:A:H41 A:A:T242 22.89564.11NoNo068
25R:R:I130 R:R:L82 15.81764.28NoYes099
26R:R:I130 R:R:Y297 15.71247.25NoYes099
27A:A:H41 R:R:L142 18.84975.14NoYes067
28B:B:G324 B:B:T321 97.82343.64YesYes497
29B:B:G324 B:B:K280 90.62153.49YesYes491
30B:B:K280 G:G:H44 90.65915.24YesNo016
31G:G:H44 G:G:Y40 90.557120.69NoYes066
32B:B:N237 G:G:Y40 86.1889.3YesYes1156
33B:B:G238 B:B:N237 86.77733.39NoYes075
34B:B:F234 B:B:G238 86.67573.01YesNo057
35B:B:F234 B:B:V200 85.99337.87YesNo056
36B:B:F241 B:B:V200 75.406220.97YesNo066
37B:B:F241 B:B:F253 71.86676.43YesYes766
38B:B:F253 B:B:H225 72.17573.39YesYes769
39B:B:H225 B:B:S245 73.27748.37YesNo799
40B:B:S227 B:B:S245 73.25623.26NoNo069
41B:B:D228 B:B:S227 73.2485.89YesNo096
42B:B:C204 B:B:D228 72.47546.22YesYes979
43B:B:C204 B:B:D186 72.49226.22YesYes979
44B:B:D186 B:B:Y145 72.26093.45YesYes998
45B:B:M101 B:B:Y145 36.22495.99NoYes098
46B:B:M101 B:B:Y59 36.02155.99NoNo098
47B:B:Q75 B:B:Y59 35.060216.91YesNo098
48B:B:Q75 B:B:W99 34.84618.76YesYes599
49A:A:F238 B:B:W99 69.39776.01YesYes599
50B:B:L117 B:B:Y145 35.92863.52NoYes098
51A:A:I207 B:B:L117 35.86075.71NoNo099
52A:A:F222 A:A:I207 34.97775.02YesNo579
53A:A:F222 B:B:W99 34.761617.04YesYes579
54A:A:F238 A:A:L44 34.115219.49YesNo599
55A:A:F238 A:A:V241 34.11523.93YesNo599
56A:A:I244 A:A:L44 33.96939.99YesNo589
57A:A:I244 A:A:V241 33.96933.07YesNo589
58A:A:I244 A:A:V287 67.36064.61YesNo086
59A:A:L289 A:A:V287 58.72012.98YesNo096
60A:A:A249 A:A:K293 11.95783.21NoNo089
61A:A:K293 A:A:S251 13.15346.12NoYes099
62A:A:L297 A:A:Y253 17.33483.52YesYes088
63A:A:Y253 A:A:Y311 35.26586.95YesYes086
64A:A:F312 A:A:Y311 38.25023.09YesYes086
65A:A:F312 A:A:L266 19.71356.09YesNo088
66A:A:I341 A:A:L266 20.30897.14NoNo088
67A:A:F345 A:A:I341 20.60696.28YesNo088
68A:A:F345 A:A:L289 47.42183.65YesYes689
69A:A:E344 A:A:F312 19.71558.16NoYes1658
70A:A:E344 A:A:L270 22.99883.98NoYes056
71A:A:F345 A:A:L270 25.08523.65YesYes086
72A:A:R380 R:R:L142 17.37166.07YesYes377
73A:A:Q384 A:A:R380 16.9663.5NoYes367
74A:A:Q384 R:R:H223 16.53757.42NoYes367
75A:A:D378 A:A:Y360 12.037711.49NoYes078
76A:A:V301 A:A:V334 13.15343.21NoNo074
77A:A:E330 A:A:V334 10.76214.28NoNo034
78B:B:L210 B:B:V200 13.86344.47YesNo056
79B:B:L70 B:B:W82 58.42686.83YesYes259
80B:B:H54 B:B:W82 19.79246.35YesYes299
81B:B:H54 B:B:S74 58.86616.97YesNo099
82B:B:M61 B:B:S72 19.60623.07NoYes069
83B:B:L70 B:B:W63 78.11617.97YesYes057
84R:R:L127 R:R:N289 25.75894.12YesYes189
85R:R:F256 R:R:N289 17.46817.25YesYes199
86R:R:F202 R:R:F256 16.45846.43YesYes189
87L:L:?1 R:R:F202 30.40716.37YesYes108
88R:R:L82 R:R:N293 25.41026.87YesYes199
89R:R:N289 R:R:N293 25.815312.26YesYes199
90R:R:N289 R:R:W260 33.286813.56YesYes198
91R:R:F202 R:R:W260 16.44069.02YesYes188
92R:R:I124 R:R:W260 15.81719.4NoYes188
93L:L:?1 R:R:I124 15.192911.2YesNo108
94L:L:?1 R:R:L190 11.8856.03YesYes103
95L:L:?1 R:R:L198 15.640110.86YesNo006
96R:R:D86 R:R:L82 16.11074.07YesYes199
97R:R:D86 R:R:N58 11.353613.46YesYes199
98R:R:M291 R:R:Y288 13.70175.99YesNo054
99R:R:L284 R:R:Y288 13.36817.03NoNo044
100R:R:L284 R:R:P285 12.03324.93NoNo047
101R:R:P262 R:R:P285 11.69943.9NoNo097
102R:R:P262 R:R:T282 11.36553.5NoNo098
103R:R:T282 R:R:Y266 11.03177.49NoYes083
104R:R:H194 R:R:L198 13.764812.86YesNo076
105B:B:T321 B:B:W63 97.63626.06YesYes077
106B:B:M61 B:B:W63 19.61273.49NoYes067
107B:B:H54 B:B:S72 39.02915.58YesYes299
108B:B:D76 B:B:S74 58.816710.31YesNo099
109B:B:L70 B:B:S72 19.60694.5YesYes259
110B:B:I80 B:B:W82 39.29449.4YesYes289
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:T121 5.14 1 Yes No 0 6 0 1
L:L:?1 R:R:I124 11.2 1 Yes No 0 8 0 1
L:L:?1 R:R:G125 2.98 1 Yes No 0 5 0 1
L:L:?1 R:R:V187 5.19 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L190 6.03 1 Yes Yes 0 3 0 1
L:L:?1 R:R:L198 10.86 1 Yes No 0 6 0 1
L:L:?1 R:R:F202 6.37 1 Yes Yes 0 8 0 1
L:L:?1 R:R:V205 3.9 1 Yes No 0 8 0 1
L:L:?1 R:R:F263 4.25 1 Yes No 0 6 0 1
R:R:P189 R:R:V113 10.6 1 Yes No 3 4 2 2
R:R:L190 R:R:V113 4.47 1 Yes No 3 4 1 2
R:R:A164 R:R:T121 3.36 0 No No 8 6 2 1
R:R:L167 R:R:T121 5.9 0 No No 6 6 2 1
R:R:I124 R:R:V205 4.61 1 No No 8 8 1 1
R:R:I124 R:R:W260 9.4 1 No Yes 8 8 1 2
R:R:G125 R:R:V160 3.68 0 No No 5 6 1 2
R:R:L128 R:R:V205 5.96 0 No No 7 8 2 1
R:R:L167 R:R:L198 5.54 0 No No 6 6 2 1
R:R:P189 R:R:V187 3.53 1 Yes Yes 3 5 2 1
R:R:L190 R:R:V187 2.98 1 Yes Yes 3 5 1 1
R:R:L195 R:R:V187 2.98 0 No Yes 5 5 2 1
R:R:L190 R:R:P189 4.93 1 Yes Yes 3 3 1 2
R:R:H194 R:R:L198 12.86 0 Yes No 7 6 2 1
R:R:C267 R:R:L195 7.94 0 No No 6 5 2 2
R:R:F202 R:R:F203 5.36 1 Yes No 8 4 1 2
R:R:F202 R:R:F256 6.43 1 Yes Yes 8 9 1 2
R:R:F202 R:R:W260 9.02 1 Yes Yes 8 8 1 2
R:R:F202 R:R:T264 15.56 1 Yes No 8 5 1 2
R:R:F203 R:R:T264 7.78 1 No No 4 5 2 2
R:R:F256 R:R:W260 6.01 1 Yes Yes 9 8 2 2
R:R:C267 R:R:F263 8.38 0 No No 6 6 2 1
L:L:?1 R:R:A201 2.75 1 Yes No 0 4 0 1
R:R:F202 R:R:L261 2.44 1 Yes No 8 4 1 2
R:R:F203 R:R:L261 2.44 1 No No 4 4 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
54.55Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
50.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
46.15Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
46.15Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
45.45Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
42.86Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
42.86Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
41.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
41.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
41.67Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
41.18Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
37.50Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
37.50Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
35.71Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.71Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
35.29Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
35.29Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
33.33Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
33.33Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
33.33Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
31.58Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
31.58Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
30.77Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
30.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
29.41Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
29.41Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.41Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
29.41Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
29.41Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
29.41Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
29.41Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.41Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
28.57Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
28.57Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
28.57Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
28.57Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
28.57Single6ME9Ramelteon6ME9-MT2-Ramelteon
28.57Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
28.57Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
28.57Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
28.57Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
28.57Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
28.57Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
28.57Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
27.78Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
27.78Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
27.78Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
26.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
26.67Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
26.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
26.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
26.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
26.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
26.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
26.67Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
26.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
26.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
26.67Consensussensory_offOrthosteric Ligandopsins_off
26.32Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
26.32Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
26.32Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
25.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
25.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
25.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
25.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
23.81Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
23.53Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
23.53Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
23.53Single8TF5Oleic acid8TF5-GPR6-Oleic acid
23.53Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
23.53Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.53Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.08Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.08Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
23.08Single6ME5Agomelatine6ME5-MT1-Agomelatine
23.08Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
23.08Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
23.08Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
23.08Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
23.08Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
22.73Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
22.73Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.22Single5V54Methiothepin5V54-5-HT1B-Methiothepin
22.22Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.22Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.22Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.22Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
22.22Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.22Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
22.22Consensus5ht1_offOrthosteric Ligand5ht1b_off
22.22Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
22.22Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
22.22Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.22Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.22Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
21.43Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
21.43Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
21.43Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
21.43Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
21.43Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
21.43Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.43Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
21.43Single8K9LVV98K9L-μ-Damgo-VV9-Gi3/β1/γ1
21.43Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.43Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
21.43Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
21.43Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.43Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.05Single4N4WSANT-14N4W-SMO-SANT-1
21.05Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
21.05Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
21.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.05Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.05Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
21.05Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
21.05Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
21.05Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
21.05Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.05Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
21.05Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
21.05Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.05Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.83Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
20.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
20.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
20.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
20.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
20.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
20.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
20.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
20.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
20.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
20.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
20.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
20.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
20.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
20.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
20.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
19.05Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
19.05Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
19.05Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
19.05Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
18.75Single5O9HNDT95137275O9H-C5a1-NDT9513727
18.75Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
18.75Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
18.75Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
18.75Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
18.75Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
18.75Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
18.75Single7UL3Famotidine7UL3-H2-Famotidine
18.75Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.75Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
18.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
18.75Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
18.75Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
18.75Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
18.75Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
18.75Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
18.75Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
18.52Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
18.18Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
18.18Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
18.18Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
18.18Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
18.18Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
18.18Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensuslpl_onOrthosteric Ligands1p_on lpa_on
18.18Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
17.65Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
17.65Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
17.65Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
17.65Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
17.65Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
17.65Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
17.65Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
17.65Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
17.65Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
17.65Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
17.65Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
17.65Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
17.65Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
17.65Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
17.65Single8T1WCVN4248T1W-GPR6-CVN424
17.65Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
17.65Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
17.65Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
17.65Single8X64Desloratadine8X64-H1-Desloratadine
17.65Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
17.65Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.65Single9CHXS-Carazolol9CHX-β2-S-Carazolol
17.65Single9IYAONO-97105319IYA-GPR55-ONO-9710531
17.65Consensus5ht5_onOrthosteric Ligand5ht5a_on
17.65Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
17.65Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
17.65Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
17.65Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
17.65Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
17.39Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
17.39Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
17.39Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.39Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
16.67Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
16.67Single4NTJAZD12834NTJ-P2Y12-AZD1283
16.67Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
16.67Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
16.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
16.67Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
16.67Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
16.67Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
16.67Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
16.67Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
16.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
16.67Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
16.67Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.67Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
16.67Single8JXSPF-61428JXS-D1-PF-6142
16.67Single8PWNTheophylline8PWN-A2A-Theophylline
16.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
16.67Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
16.67Single8ZMFA1L108ZMF-5-HT2C-A1L10
16.67Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
16.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
16.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
16.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
16.67Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.67Consensusa3_on_gpOrthosteric Liganda3a_on_gp
16.67Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
16.67Consensusangiotensin_onOrthosteric Ligandat1_on
16.67Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.67Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
16.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
16.67Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
16.67Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
16.67Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
16.67Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensustrace-amine_onOrthosteric Ligandta1_on
16.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
16.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
16.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
15.79Single2YDVNECA2YDV-A2A-NECA
15.79Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
15.79Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
15.79Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.79Single4U15Tiotropium4U15-M3-Tiotropium
15.79Single4UHRCGS216804UHR-A2A-CGS21680
15.79Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
15.79Single5G53NECA5G53-A2A-NECA-Gs
15.79Single5TZRMK86665TZR-FFA1-MK8666
15.79Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
15.79Single6J21Aprepitant6J21-NK1-Aprepitant
15.79Single6OL9Tiotropium6OL9-M5-Tiotropium
15.79Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
15.79Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
15.79Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
15.79Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.79Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
15.79Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
15.79Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
15.79Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
15.79Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
15.79Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
15.79Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
15.79Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
15.79Single8EA0Iperoxo8EA0-M3-Iperoxo
15.79Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
15.79Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.79Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
15.79Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
15.79Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
15.79Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
15.79Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
15.79Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
15.79Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
15.79Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
15.79Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
15.79Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
15.79Consensusa2_onOrthosteric Liganda2b_on
15.79Consensusa2_on_gpOrthosteric Liganda2b_on_gp
15.79Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.79Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.79Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
15.79Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
15.79Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
15.79Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
15.79Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
15.79Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.79Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.79Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
15.79Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
15.79Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
15.79Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
15.38Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
15.38Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.38Single8A2OTheophylline8A2O-A2A-Theophylline-Na
15.38Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
15.38Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
15.38Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
15.38Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
15.38Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.38Consensussensory_onOrthosteric Ligandopsins_on
15.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
15.00Single3D4STimolol3D4S-β2-Timolol
15.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
15.00Single5CXVTiotropium5CXV-M1-Tiotropium
15.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
15.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
15.00Single7DFPSpiperone7DFP-D2-Spiperone
15.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
15.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
15.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
15.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
15.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
15.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
15.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
15.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
15.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
15.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
15.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
15.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
15.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
15.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
15.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
15.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
15.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
15.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
15.00Consensuslpa_offOrthosteric Ligandlpa1_off
15.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
15.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
14.29Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
14.29Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
14.29Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
14.29Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
14.29Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
14.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.29Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
14.29Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
14.29Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
14.29Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
14.29Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
14.29Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
14.29Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
14.29Single7UM4AS26747237UM4-5-HT5A-AS2674723
14.29Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
14.29Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
14.29Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
14.29Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
14.29Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
14.29Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
14.29Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
14.29Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
14.29Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
14.29Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
14.29Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
14.29Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
14.29Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
14.29Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
14.29Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
14.29Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
14.29Consensuschemerin_onOrthosteric Ligandcml1_on
14.29Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
14.29Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusgi_sensoryOrthosteric Ligandgi_opsins
14.29Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
14.29Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
14.29Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.79Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
13.79Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.64Single3NY9ICI118-5513NY9-β2-ICI118-551
13.64Single4UG2CGS216804UG2-A2A-CGS21680
13.64Single5EE7MK08935EE7-Glucagon-MK0893
13.64Single5WF6UK-4320975WF6-A2A-UK-432097
13.64Single5ZTYAM102575ZTY-CB2-AM10257
13.64Single7SK9CCX6627SK9-ACKR3-CCX662
13.64Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
13.64Single8IEIA1LYA8IEI-GPR156-A1LYA
13.64Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
13.64Single8X5YAstemizole8X5Y-H1-Astemizole
13.64Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
13.64Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
13.64Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
13.64Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
13.64Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.64Consensuskisspeptin_onOrthosteric Ligandkiss1_on
13.64Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
13.33Single3PBLEticlopride3PBL-D3-Eticlopride
13.33Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
13.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
13.33Single6HLLCP999946HLL-NK1-CP99994
13.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
13.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
13.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
13.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.33Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
13.33Single7SRQLSD7SRQ-5-HT2B-LSD
13.33Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
13.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
13.33Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
13.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
13.33Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
13.33Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
13.33Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
13.33Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
13.33Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.33Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.33Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
13.33Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
13.33Single9B9Y7DY9B9Y-CB1-7DY
13.33Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
13.33Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
13.33Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
13.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.04Single4IARErgotamine4IAR-5-HT1B-Ergotamine
13.04Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
13.04Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
13.04Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
13.04Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
13.04Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
13.04Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
13.04Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
13.04Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.04Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.04Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
13.04Single8IEBA1LYA8IEB-GPR156-A1LYA
13.04Single8IEIA1LYA8IEI-GPR156-A1LYA
13.04Single8IEPA1LYA8IEP-GPR156-A1LYA
13.04Single8IEPA1LYA8IEP-GPR156-A1LYA
13.04Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
13.04Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
13.04Single8WDTphotoNECA8WDT-A2A-photoNECA
13.04Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
13.04Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
13.04Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
13.04Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.04Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.04Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
13.04Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
13.04Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
13.04Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
13.04Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.04Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.50Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.50Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.50Single3PWHZM-2413853PWH-A2A-ZM-241385
12.50Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
12.50Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
12.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
12.50Single5WS3EMPA5WS3-OX2-EMPA
12.50Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
12.50Single6AKXA4R6AKX-CCR5-A4R
12.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
12.50Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
12.50Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
12.50Single6HLOAprepitant6HLO-NK1-Aprepitant
12.50Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
12.50Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
12.50Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
12.50Single6TODEMPA6TOD-OX1-EMPA-Na
12.50Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
12.50Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.50Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
12.50Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7SHEPI; PE7SHE-GPR158-PI; PE
12.50Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
12.50Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
12.50Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
12.50Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
12.50Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
12.50Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
12.50Single7XRRLemborexant7XRR-OX2-Lemborexant
12.50Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
12.50Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
12.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
12.50Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
12.50Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
12.50Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
12.50Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
12.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
12.50Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
12.50Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
12.50Single8IEBA1LYA8IEB-GPR156-A1LYA
12.50Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
12.50Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
12.50Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
12.50Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
12.50Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
12.50Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
12.50Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.50Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
12.50Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
12.50Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.50Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
12.50Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
12.50Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
12.50Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.50Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
12.50Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.50Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
12.50Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
12.50Consensusorexin_offOrthosteric Ligandox2_off ox1_off
12.50Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
12.50Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
12.00Single5WF5UK-4320975WF5-A2A-UK-432097
12.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
12.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
12.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
12.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
12.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
12.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
12.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
12.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
12.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
12.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
11.76Single2YDOAdenosine2YDO-A2A-Adenosine
11.76Single3RZECidoxepin3RZE-H1-Cidoxepin
11.76Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
11.76Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
11.76Single4MBSMaraviroc4MBS-CCR5-Maraviroc
11.76Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
11.76Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
11.76Single4ZJCSB-6740424ZJC-OX1-SB-674042
11.76Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
11.76Single5IU7Q274563465IU7-A2A-Q27456346-Na
11.76Single5IUBQ274563445IUB-A2A-Q27456344-Na
11.76Single5JTBZM-2413855JTB-A2A-ZM-241385
11.76Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
11.76Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
11.76Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
11.76Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
11.76Single5UVIZM-2413855UVI-A2A-ZM-241385
11.76Single6A94Zotepine6A94-5-HT2A-Zotepine
11.76Single6AQFZM-2413856AQF-A2A-ZM-241385
11.76Single6FFIMMPEP6FFI-mGlu5-MMPEP
11.76Single6KUXRS-799486KUX-α2a-RS-79948
11.76Single6MH8ZM-2413856MH8-A2A-ZM-241385
11.76Single6PS0S-Carazolol6PS0-β2-S-Carazolol
11.76Single6PS4ICI118-5516PS4-β2-ICI118-551
11.76Single6PS5S-Propranolol6PS5-β2-S-Propranolol
11.76Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
11.76Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
11.76Single6TPGEMPA6TPG-OX2-EMPA
11.76Single6TPNHTL66416TPN-OX2-HTL6641
11.76Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
11.76Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
11.76Single7AROLUF58337ARO-A2A-LUF5833-Na
11.76Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
11.76Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
11.76Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
11.76Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
11.76Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
11.76Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
11.76Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
11.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.76Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single7T32ZM-2413857T32-A2A-ZM-241385
11.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
11.76Single7VODCariprazine7VOD-5-HT2A-Cariprazine
11.76Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
11.76Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
11.76Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.76Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
11.76Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
11.76Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
11.76Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
11.76Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
11.76Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
11.76Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
11.76Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
11.76Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
11.76Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
11.76Single8IYXYL-3658IYX-GPR34-YL-365
11.76Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
11.76Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
11.76Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
11.76Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
11.76Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
11.76Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
11.76Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
11.76Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
11.76Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
11.76Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
11.76Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.76Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
11.76Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
11.76Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
11.76Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
11.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9BJKNaloxone9BJK-μ-Naloxone-NAM
11.76Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.76Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
11.76Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
11.76Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
11.76Consensusa2_offOrthosteric Liganda2a_off
11.76Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
11.76Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
11.76Consensusalpha1_onOrthosteric Ligandalpha1a_on
11.76Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
11.76Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.76Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.76Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
11.76Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.76Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.76Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
11.76Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
11.54Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
11.54Single6JODAngiotensin II6JOD-AT2-Angiotensin II
11.54Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
11.54Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.54Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
11.54Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
11.54Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
11.54Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
11.54Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
11.54Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
11.54Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.54Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
11.54Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
11.54Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
11.54Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
11.54Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
11.54Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
11.11Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
11.11Single2Y01Dobutamine2Y01-β1-Dobutamine
11.11Single2Y02Carmoterol2Y02-β1-Carmoterol
11.11Single2Y04Salbutamol2Y04-β1-Salbutamol
11.11Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
11.11Single3EMLZM-2413853EML-A2A-ZM-241385
11.11Single3NY8ICI118-5513NY8-β2-ICI118-551
11.11Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
11.11Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
11.11Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
11.11Single4EJ4Naltrindole4EJ4-δ-Naltrindole
11.11Single4GBRS-Carazolol4GBR-β2-S-Carazolol
11.11Single4MQSIperoxo4MQS-M2-Iperoxo
11.11Single4QKX35V4QKX-β2-35V
11.11Single4U14Tiotropium4U14-M3-Tiotropium
11.11Single5IU8Q274563475IU8-A2A-Q27456347-Na
11.11Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
11.11Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
11.11Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
11.11Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
11.11Single5TGZAM65385TGZ-CB1-AM6538
11.11Single5UENDU1725UEN-A1-DU172
11.11Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
11.11Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
11.11Single6DRXLisuride6DRX-5-HT2B-Lisuride
11.11Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
11.11Single6FFHFenobam6FFH-mGlu5-Fenobam
11.11Single6H7MSalbutamol6H7M-β1-Salbutamol
11.11Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.11Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
11.11Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
11.11Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
11.11Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
11.11Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
11.11Single6S0LZM-2413856S0L-A2A-ZM-241385
11.11Single6TOTLemborexant6TOT-OX1-Lemborexant
11.11Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
11.11Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
11.11Single7BU7BI1671077BU7-β1-BI167107
11.11Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
11.11Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
11.11Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
11.11Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
11.11Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.11Single7PYRPSB-21157PYR-A2A-PSB-2115
11.11Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
11.11Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
11.11Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
11.11Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.11Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.11Single7UL4Alvimopan7UL4-μ-Alvimopan
11.11Single7V3ZCP559407V3Z-CB1-CP55940
11.11Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
11.11Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
11.11Single7WC7Lisuride7WC7-5-HT2A-Lisuride
11.11Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
11.11Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
11.11Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
11.11Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.11Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
11.11Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.11Single8CU6LJ-45178CU6-A2A-LJ-4517
11.11Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
11.11Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
11.11Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
11.11Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
11.11Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
11.11Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
11.11Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
11.11Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
11.11Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
11.11Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
11.11Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
11.11Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
11.11Single8JXRLSD8JXR-D1-LSD
11.11Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
11.11Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
11.11Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
11.11Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
11.11Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.11Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
11.11Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
11.11Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
11.11Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
11.11Single8X63Mepyramine8X63-H1-Mepyramine
11.11Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
11.11Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
11.11Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
11.11Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
11.11Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
11.11Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
11.11Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
11.11Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
11.11Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
11.11Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
11.11Consensusa3_onOrthosteric Liganda3a_on
11.11Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
11.11Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
11.11Consensusalpha2_onOrthosteric Ligandalpha2b_on
11.11Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
11.11Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.11Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.11Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
11.11Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
11.11Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
11.11Consensusblt_onOrthosteric Ligandblt1_on
11.11Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
11.11Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.11Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
11.11Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
11.11Consensusdopamine_offOrthosteric Ligandd2_off d3_off
11.11Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
11.11Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
11.11Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
11.11Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
11.11Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
11.11Consensushistamine_offOrthosteric Ligandh1_off
11.11Consensusleukotriene_onOrthosteric Ligandblt_on
11.11Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
11.11Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
11.11Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
11.11Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
11.11Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
11.11Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
11.11Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.71Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.71Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
10.71Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.71Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.71Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.71Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
10.71Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
10.71Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
10.71Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
10.71Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
10.71Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
10.53Single2RH1S-Carazolol2RH1-β2-S-Carazolol
10.53Single2Y00Dobutamine2Y00-β1-Dobutamine
10.53Single2Y03Isoprenaline2Y03-β1-Isoprenaline
10.53Single2YCWS-Carazolol2YCW-β1-S-Carazolol
10.53Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
10.53Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
10.53Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
10.53Single5C1MBU725C1M-μ-BU72
10.53Single5D6LS-Carazolol5D6L-β2-S-Carazolol
10.53Single5IUAQ274563485IUA-A2A-Q27456348-Na
10.53Single5JQHS-Carazolol5JQH-β2-S-Carazolol
10.53Single5N2RPSB-365N2R-A2A-PSB-36-Na
10.53Single5N2SPSB365N2S-A1-PSB36
10.53Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
10.53Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
10.53Single5TVNLSD5TVN-5-HT2B-LSD
10.53Single5WIUNemonapride5WIU-D4-Nemonapride
10.53Single5WIVNemonapride5WIV-D4-Nemonapride-Na
10.53Single5WQCEMPA5WQC-OX2-EMPA
10.53Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
10.53Single5XPRBosentan5XPR-ETB-Bosentan
10.53Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
10.53Single6D26Fevipiprant6D26-DP2-Fevipiprant
10.53Single6E67BI1671076E67-β2-BI167107-Gs (fused)
10.53Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
10.53Single6HLPNetupitant6HLP-NK1-Netupitant
10.53Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
10.53Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.53Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
10.53Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.53Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
10.53Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
10.53Single6S0QZM-2413856S0Q-A2A-ZM-241385
10.53Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
10.53Single6TP6Filorexant6TP6-OX1-Filorexant
10.53Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
10.53Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
10.53Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.53Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
10.53Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
10.53Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
10.53Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
10.53Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
10.53Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
10.53Single7W41PD1762527W41-BB2-PD176252
10.53Single7WC6LSD7WC6-5-HT2A-LSD
10.53Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
10.53Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
10.53Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
10.53Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
10.53Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
10.53Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
10.53Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GNEKW-63568GNE-A2A-KW-6356-Na
10.53Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
10.53Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
10.53Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
10.53Single8S4DCMF-0198S4D-Apelin-CMF-019
10.53Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.53Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.53Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.53Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
10.53Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.53Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
10.53Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
10.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
10.53Consensusadenosine_offOrthosteric Liganda1_off a2_off
10.53Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
10.53Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
10.53Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
10.53Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
10.53Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
10.53Consensusamine_offonOrthosteric Ligandamine_off amine_on
10.53Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
10.53Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
10.53Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
10.53Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
10.53Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
10.53Consensusbombesin_offOrthosteric Ligandbb2_off
10.53Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
10.53Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
10.53Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.53Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
10.53Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.53Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
10.53Consensusdp_offOrthosteric Liganddp2_off
10.53Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
10.53Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
10.53Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
10.53Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.53Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.34Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.34Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.34Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.34Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
10.34Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
10.34Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.34Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
10.34Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
10.34Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
10.34Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
10.34Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
10.34Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
10.34Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
10.34Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
10.00Single3P0GBI1671073P0G-β2-BI167107
10.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
10.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
10.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
10.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
10.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
10.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
10.00Single5XR8AM8415XR8-CB1-AM841
10.00Single5XRAAM115425XRA-CB1-AM11542
10.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
10.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
10.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
10.00Single6IGLIRL16206IGL-ETB-IRL1620
10.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
10.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
10.00Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.00Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.00Single6WGTLSD6WGT-5-HT2A-LSD
10.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
10.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
10.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
10.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
10.00Single7PX4PSB-21137PX4-A2A-PSB-2113
10.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
10.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
10.00Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
10.00Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
10.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
10.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
10.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
10.00Single8E0GBU728E0G-μ-BU72
10.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
10.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
10.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
10.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
10.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
10.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
10.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
10.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
10.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
10.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
10.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8XVLZibotentan8XVL-ETA-Zibotentan
10.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
10.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
10.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
10.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
10.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
10.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
10.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
10.00Consensusbradykinin_onOrthosteric Ligandbk2_on
10.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
10.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
10.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
10.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
10.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
10.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
10.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
10.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
10.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
10.00Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
10.00Consensuslpa_onOrthosteric Ligandlpa1_on
10.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
10.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
10.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
10.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
10.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
10.00Consensustachykinin_offOrthosteric Ligandnk1_off
9.68Single5GLHEndothelin-15GLH-ETB-Endothelin-1
9.68Single6IGKEndothelin-36IGK-ETB-Endothelin-3
9.68Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.68Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
9.68Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
9.52Single4AMIBucindolol4AMI-β1-Bucindolol
9.52Single4LDEBI1671074LDE-β2-BI167107
9.52Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.52Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.52Single4RWADIPP-NH24RWA-δ-DIPP-NH2
9.52Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
9.52Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
9.52Single6A93Risperidone6A93-5-HT2A-Risperidone
9.52Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
9.52Single6CM4Risperidone6CM4-D2-Risperidone
9.52Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
9.52Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
9.52Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
9.52Single6KQICP559406KQI-CB1-CP55940-Org27569
9.52Single6MXTSalmeterol6MXT-β2-Salmeterol
9.52Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
9.52Single6ZG4HTL00099366ZG4-M1-HTL0009936
9.52Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
9.52Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
9.52Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
9.52Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single7SHEPI; PE7SHE-GPR158-PI; PE
9.52Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
9.52Single7YITNalfurafine7YIT-κ-Nalfurafine
9.52Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
9.52Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
9.52Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
9.52Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
9.52Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
9.52Single8JJ8Formoterol8JJ8-β2-Formoterol
9.52Single8JJLOlodaterol8JJL-β2-Olodaterol
9.52Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
9.52Single8JWY2-1188JWY-A2A-2-118
9.52Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
9.52Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
9.52Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.52Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.52Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
9.52Single8XYIVUF106618XYI-CXCR3-VUF10661
9.52Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
9.52Consensusalpha1_offOrthosteric Ligandalpha1a_off
9.52Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
9.52Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
9.52Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
9.52Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
9.52Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
9.52Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
9.52Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
9.52Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
9.52Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
9.52Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
9.52Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
9.52Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
9.52Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
9.52Consensuslpl_offOrthosteric Ligands1p_off lpa_off
9.52Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
9.52Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
9.52Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
9.52Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
9.52Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
9.52Consensusorexin_onOrthosteric Ligandox2_on
9.52Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
9.38Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
9.38Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.38Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.38Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
9.38Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
9.38Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
9.38Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
9.38Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
9.38Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
9.38Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
9.09Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
9.09Single5CGDHTL142425CGD-mGlu5-HTL14242
9.09Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
9.09Single5X93K-87945X93-ETB-K-8794
9.09Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
9.09Single6H7LDobutamine6H7L-β1-Dobutamine
9.09Single6IBLArformoterol6IBL-β1-Arformoterol
9.09Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
9.09Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
9.09Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
9.09Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.09Single7EZCUKA7EZC-A2A-UKA
9.09Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
9.09Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
9.09Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
9.09Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
9.09Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
9.09Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
9.09Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
9.09Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
9.09Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
9.09Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8XVJMacitentan8XVJ-ETA-Macitentan
9.09Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
9.09Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.09Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.09Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
9.09Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
9.09Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
9.09Consensusendothelin_offOrthosteric Ligandetb_off
9.09Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
9.09Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
9.09Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
9.09Consensusprostanoid_offOrthosteric Ligandep_off dp_off
8.82Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
8.82Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
8.82Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
8.70Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
8.70Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.70Single6KNMJN241-96KNM-Apelin-JN241-9
8.70Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.70Single6PT3DPI-2876PT3-δ-DPI-287
8.70Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
8.70Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.70Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
8.70Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.70Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
8.70Single7XN9L-054,5227XN9-SST2-L-054,522
8.70Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
8.70Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
8.70Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
8.70Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
8.70Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
8.70Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
8.70Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8QJ2pN1628QJ2-MC4-pN162-Gs
8.70Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
8.70Single8XQJJN2418XQJ-Apelin-JN241
8.70Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.70Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.70Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
8.70Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.70Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.70Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
8.70Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.70Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.33Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
8.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
8.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
8.33Single7F8XNN90567F8X-CCKA-NN9056
8.33Single7QA8Peptide7QA8-STE2-Peptide
8.33Single7QA8Peptide7QA8-STE2-Peptide
8.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
8.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
8.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
8.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
8.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
8.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
8.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
8.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
8.33Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
8.33Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
8.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
8.33Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
8.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.33Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
8.33Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.00Single3QAKUK-4320973QAK-A2A-UK-432097
8.00Single5KW2PubChem 1330539535KW2-FFA1-PubChem 133053953
8.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
8.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
8.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
8.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
8.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
8.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
8.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
8.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
8.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
8.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
8.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
8.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
8.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
8.00Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
8.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
8.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
7.89Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.69Single5XSZGlyceryl-mono-oleate5XSZ-LPA6-Glyceryl-mono-oleate
7.69Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.69Single6PT2KGCHM076PT2-δ-KGCHM07
7.69Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
7.69Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
7.69Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
7.69Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.69Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.69Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
7.69Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
7.69Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.69Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
7.69Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
7.69Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.69Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
7.69Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
7.69Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.69Single9K1DCholesterol9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
7.69Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
7.69Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
7.69Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
7.69Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.41Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.41Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.41Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
7.41Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
7.41Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
7.41Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
7.41Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
7.41Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
7.41Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
7.41Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
7.41Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
7.41Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
7.41Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.41Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
7.41Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
7.41Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.41Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.41Consensusvasop-oxy_onOrthosteric Ligandv2_on
7.41Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
7.14Single3RFMCaffeine3RFM-A2A-Caffeine
7.14Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.14Single6TQ9SB-4081246TQ9-OX1-SB-408124
7.14Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
7.14Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
7.14Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
7.14Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.14Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
7.14Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
7.14Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.14Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
7.14Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
7.14Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
7.14Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.14Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
7.14Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
7.14Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
7.14Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
7.14Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
7.14Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
7.14Single8ZRTET-18ZRT-ETB-ET-1
7.14Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9CHUNoradrenaline9CHU-β2-Noradrenaline
7.14Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
7.14Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
7.14Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
7.14Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.14Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.14Consensusp2y_offOrthosteric Ligandp2y1_off
6.90Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
6.90Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
6.90Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
6.90Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
6.90Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.90Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
6.90Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.90Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
6.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.90Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
6.90Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
6.90Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
6.90Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
6.67Single3OE6IT1t3OE6-CXCR4-IT1t
6.67Single3UZAGTPL92363UZA-A2A-GTPL9236
6.67Single4XNWMRS25004XNW-P2Y1-MRS2500
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
6.67Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
6.67Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
6.67Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
6.67Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.67Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.67Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
6.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.67Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
6.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.67Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.67Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
6.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
6.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
6.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
6.67Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
6.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.67Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
6.67Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
6.67Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
6.67Single8ZPLCholesterol8ZPL-CXCR4-HF51116-Cholesterol
6.67Single8ZPMCholesterol8ZPM-CXCR4-AMD070-Cholesterol
6.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.67Consensus5ht2_onOrthosteric Ligand5ht2b_on
6.67Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
6.67Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
6.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
6.45Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
6.45Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.45Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
6.45Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.45Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.45Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.45Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
6.45Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
6.25Single3OE9IT1t3OE9-CXCR4-IT1t
6.25Single4O9RCyclopamine4O9R-SMO-Cyclopamine
6.25Single5L7IVismodegib5L7I-SMO-Vismodegib
6.25Single6LI0C176LI0-GPR52-C17
6.25Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.25Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
6.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
6.25Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
6.25Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.25Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
6.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
6.25Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
6.25Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
6.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.25Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
6.25Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
6.25Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
6.25Single8HNNSCH5467388HNN-CXCR3-SCH546738
6.25Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
6.25Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
6.25Single8K5BNiacin8K5B-HCA2-Niacin
6.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
6.25Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
6.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
6.25Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
6.25Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
6.25Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
6.25Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
6.25Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
6.25Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
6.25Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
6.25Single9K1CDHA9K1C-FFA1-DHA-Gi1/β1/γ2
6.25Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.25Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.25Consensusbombesin_onOrthosteric Ligandbb2_on
6.25Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
6.25Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
6.25Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
6.25Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.25Consensusgq_nucleotideOrthosteric Ligandgq_p2y
6.25Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.25Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
6.25Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
6.25Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
6.06Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
6.06Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88Single3ODUIT1t3ODU-CXCR4-IT1t
5.88Single4BWBNeurotensin4BWB-NTS1-Neurotensin
5.88Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.88Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.88Single4QINSAG1.54QIN-SMO-SAG1.5
5.88Single4S0VSuvorexant4S0V-OX2-Suvorexant
5.88Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
5.88Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
5.88Single5U09Taranabant5U09-CB1-Taranabant
5.88Single5ZKQABT-4915ZKQ-PAF-ABT-491
5.88Single6B73MP11046B73-κ-MP1104
5.88Single6DS0Ly2660976DS0-5-HT2B-Ly266097
5.88Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
5.88Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
5.88Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.88Single6TPJSuvorexant6TPJ-OX2-Suvorexant
5.88Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.88Single7BR3Elagolix7BR3-GnRH1-Elagolix
5.88Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
5.88Single7F8ULintitript7F8U-CCKA-Lintitript
5.88Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.88Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.88Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.88Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.88Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.88Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.88Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.88Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
5.88Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
5.88Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.88Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
5.88Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
5.88Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
5.88Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
5.88Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
5.88Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
5.88Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
5.88Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
5.88Single8IWESpermidine8IWE-TA9-Spermidine
5.88Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
5.88Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
5.88Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.88Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
5.88Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.88Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
5.88Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
5.88Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
5.88Single8Y0HVUF114188Y0H-CXCR3-VUF11418
5.88Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88Single9BA0A1AKN9BA0-CB1-A1AKN
5.88Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
5.88Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
5.88Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Consensusalpha2_offOrthosteric Ligandalpha2c_off
5.88Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.88Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.88Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
5.88Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.88Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.88Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.88Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
5.71Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
5.71Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
5.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
5.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.56Single3REYXAC3REY-A2A-XAC
5.56Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
5.56Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.56Single6IQLL7458706IQL-D4-L745870
5.56Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
5.56Single6TP3Nemorexant6TP3-OX1-Nemorexant
5.56Single6TPKRetosiban6TPK-OT-Retosiban
5.56Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.56Single6V9SGTPL114036V9S-OX1-GTPL11403
5.56Single6VI4JDTic6VI4-κ-JDTic
5.56Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
5.56Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.56Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.56Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
5.56Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
5.56Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
5.56Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
5.56Single7VV6C48/807VV6-MRGPRX2-C48/80
5.56Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.56Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
5.56Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
5.56Single8IHKAcifran8IHK-HCA3-Acifran
5.56Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
5.56Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
5.56Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
5.56Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
5.56Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
5.56Single8K5CAcipimox8K5C-HCA2-Acipimox
5.56Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
5.56Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.56Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
5.56Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
5.56Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
5.56Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.56Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
5.56Consensusgrh_offOrthosteric Ligandgnrh1_off
5.56Consensushca_onOrthosteric Ligandhca2_on
5.56Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
5.56Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.56Consensusvasop-oxy_offOrthosteric Ligandot_off
5.26Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
5.26Single4DAJTiotropium4DAJ-M3-Tiotropium
5.26Single4QIMANTA XV4QIM-SMO-ANTA XV
5.26Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
5.26Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.26Single5DSGTiotropium5DSG-M4-Tiotropium
5.26Single5T04Neurotensin5T04-NTS1-Neurotensin
5.26Single5UIGCmpd-15UIG-A2A-Cmpd-1
5.26Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
5.26Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
5.26Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
5.26Single6D27CAY104716D27-DP2-CAY10471
5.26Single6IIVDaltroban6IIV-TP-Daltroban
5.26Single6PS1Timolol6PS1-β2-Timolol
5.26Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
5.26Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.26Single7F83PF-051904577F83-Ghrelin-PF-05190457
5.26Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.26Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.26Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
5.26Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
5.26Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
5.26Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
5.26Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
5.26Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
5.26Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
5.26Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
5.26Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
5.26Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.26Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.26Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
5.26Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
5.26Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JJOAlprenolol8JJO-β2-Alprenolol
5.26Single8RLNLUF58348RLN-A2A-LUF5834
5.26Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
5.26Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.26Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.26Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
5.26Single9B9ZA1AKO9B9Z-CB1-A1AKO
5.26Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
5.26Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
5.26Consensuscck_offOrthosteric Ligandccka_off
5.26Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
5.26Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.26Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
5.26Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
5.26Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
5.26Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
5.26Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
5.26Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
5.26Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
5.26Consensushca_on_gpOrthosteric Ligandhca2_on_gp
5.26Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
5.26Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
5.00Single4JKVTaladegib4JKV-SMO-Taladegib
5.00Single5CGCHTL142425CGC-mGlu5-HTL14242
5.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
5.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
5.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
5.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
5.00Single6PS6Timolol6PS6-β2-Timolol
5.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
5.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
5.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
5.00Single7SINNPS-21437SIN-CaS-NPS-2143
5.00Single7SINNPS-21437SIN-CaS-NPS-2143
5.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
5.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
5.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
5.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
5.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
5.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
5.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
5.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
5.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
5.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
5.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
5.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
5.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
5.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
5.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
5.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
5.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
5.00Consensusep_offOrthosteric Ligandep4_off
5.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
5.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
5.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
4.76Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.76Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.76Single4DJHJDTic4DJH-κ-JDTic
4.76Single5V56TC1145V56-SMO-TC114
4.76Single5V57TC1145V57-SMO-TC114
4.76Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.76Single6E59L-7607356E59-NK1-L-760735
4.76Single6J20Aprepitant6J20-NK1-Aprepitant
4.76Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
4.76Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single6TQ7SB-3348676TQ7-OX1-SB-334867
4.76Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.76Single7B6WCyclazosin7B6W-α1b-Cyclazosin
4.76Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
4.76Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.76Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
4.76Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
4.76Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
4.76Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
4.76Single7P2L4YI7P2L-mGlu5-4YI
4.76Single7R0CAVP7R0C-V2-AVP-Arrestin2
4.76Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
4.76Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.76Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
4.76Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
4.76Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
4.76Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
4.76Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
4.76Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
4.76Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
4.76Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
4.76Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
4.76Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
4.76Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
4.76Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
4.76Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
4.76Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
4.76Single8XXVA1D5Q8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
4.76Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
4.76Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
4.76Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
4.76Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
4.76Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusneurotensin_onOrthosteric Ligandnts1_on
4.76Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.76Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.55Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.55Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
4.55Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.55Single4XESNeurotensin4XES-NTS1-Neurotensin
4.55Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.55Single6IIURamatroban6IIU-TP-Ramatroban
4.55Single6OS2TRV0266OS2-AT1-TRV026
4.55Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
4.55Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.55Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
4.55Single7K15MKD0467K15-BLT1-MKD046-Na
4.55Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.55Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
4.55Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.55Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.55Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.55Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
4.55Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.55Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
4.55Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Single8JWZAB9288JWZ-A2A-AB928-Na
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.55Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8XQJJN2418XQJ-Apelin-JN241
4.55Single8XWACXCL18XWA-CXCR2-CXCL1
4.55Single8XWMCXCL68XWM-CXCR2-CXCL6
4.55Single8XWSCXCL58XWS-CXCR2-CXCL5
4.55Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
4.55Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
4.55Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.55Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
4.55Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.55Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.55Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.55Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
4.55Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.55Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.55Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.35Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.35Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
4.35Single6K1QIRL25006K1Q-ETB-IRL2500
4.35Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.35Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.35Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
4.35Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
4.35Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
4.35Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
4.35Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
4.35Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
4.35Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
4.35Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
4.35Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
4.35Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
4.35Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.35Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
4.35Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
4.35Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8XVUCXCL28XVU-CXCR2-CXCL2
4.35Single8XWFCXCL38XWF-CXCR2-CXCL3
4.35Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
4.35Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
4.35Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
4.35Consensuscck_onOrthosteric Ligandccka_on cckb_on
4.35Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
4.35Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
4.35Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
4.35Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.35Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
4.35Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
4.35Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
4.35Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
4.17Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.17Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
4.17Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
4.17Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
4.17Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
4.17Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
4.17Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
4.17Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
4.17Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.17Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single4XT1Fractalkine4XT1-US28-Fractalkine
4.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
4.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
4.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
4.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
4.00Single8WKYPG-9348WKY-MC4-PG-934
4.00Single8XWNCXCL88XWN-CXCR2-CXCL8
4.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
4.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
3.85Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
3.85Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
3.85Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.85Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
3.85Single7XNACYN1548067XNA-SST2-CYN154806
3.85Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.85Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
3.85Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
3.85Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.85Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
3.85Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
3.85Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
3.85Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
3.85Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
3.85Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
3.85Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
3.85Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
3.70Single3OE0CVX153OE0-CXCR4-CVX15
3.70Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
3.70Single6W25SHU91196W25-MC4-SHU9119-Ca
3.70Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
3.70Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
3.70Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
3.70Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
3.70Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.70Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
3.70Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
3.70Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
3.70Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
3.70Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
3.70Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.70Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.70Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
3.57Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.57Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.57Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
3.57Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.57Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
3.57Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
3.57Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
3.57Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
3.57Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
3.57Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
3.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.45Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
3.45Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
3.45Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
3.45Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
3.45Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.45Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
3.45Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
3.45Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
3.45Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
3.45Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
3.33Single4XT3Fractalkine4XT3-US28-Fractalkine
3.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
3.33Single6FJ3PTH6FJ3-PTH1-PTH
3.33Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
3.33Single7SK3CXCL127SK3-ACKR3-CXCL12
3.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
3.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
3.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.33Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
3.23Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
3.23Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
3.23Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
3.23Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
3.23Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.23Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.23Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.23Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.12Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
3.12Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
2.94Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
2.86Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
2.86Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.86Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.78Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2

PDB Summary
PDB 8U8F
Class A
SubFamily Orphan
Type Orphan
SubType GPR3
Species Homo Sapiens
Ligand Palmitic Acid
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.49
Date 2024-03-06
D.O.I. 10.1021/acs.biochem.3c00647
Net Summary
Imin 2.95
Number of Linked Nodes 836
Number of Links 996
Number of Hubs 156
Number of Links mediated by Hubs 557
Number of Communities 22
Number of Nodes involved in Communities 195
Number of Links involved in Communities 278
Path Summary
Number Of Nodes in MetaPath 111
Number Of Links MetaPath 110
Number of Shortest Paths 8639174
Length Of Smallest Path 3
Average Path Length 51.5469
Length of Longest Path 83
Minimum Path Strength 1.165
Average Path Strength 6.95399
Maximum Path Strength 21.14
Minimum Path Correlation 0.7
Average Path Correlation 0.993899
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 24.6906
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.4476
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • bioactive lipid receptor activity   • sphingosine-1-phosphate receptor activity   • metabolic process   • regulation of metabolic process   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of cellular process   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of cAMP/PKA signal transduction   • positive regulation of response to stimulus   • cAMP/PKA signal transduction   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of cAMP/PKA signal transduction   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • calcium ion homeostasis   • regulation of cytosolic calcium ion concentration   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • regulation of cellular component organization   • sexual reproduction   • regulation of reproductive process   • reproductive process   • meiotic cell cycle process   • cellular component organization   • meiotic nuclear division   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • cell cycle process   • regulation of meiotic cell cycle   • regulation of cell cycle process   • meiotic cell cycle   • organelle fission   • regulation of organelle organization   • regulation of meiotic nuclear division   • organelle organization   • nuclear division   • regulation of nuclear division
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodePLM
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodePLM
NamePalmitic Acid
SynonymsHexadecylic acid
Identifier
FormulaC16 H32 O2
Molecular Weight256.424
SMILES
PubChem985
Formal Charge0
Total Atoms50
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8U8F_Chain_A
NEEKAQREA NKKIEKQLQ KDKQVYRAT HRLLLLGAG ESGKNTIVK 
QMRISGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ CFNDVTAII 
FVVASSSYQ TNRLQAALK LFDSIWNNK WLRDTSVIL FLNKQDLLA 
EKVLAGKSK IEDYFPEFA RYTTPEDAT PEPGEDPRV TRAKYFIRD 
EFLRISTAS GDGRHYCYP HFTCSVDTE NIRRVFNDC RDIIQRMHL 
RQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8U8F_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8U8F_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46089
Sequence
>8U8F_Chain_R
SPKAWDVVL CISGTLVSC ENALVVAII VGTPAFRAP MFLLVGSLA 
VADLLAGLG LVLHFAAVF CIGSAEMSL VLVGVLAMA FTASIGSLL 
AITVDRYLS LYNALTYYS ETTVTRTYV MLALVWGGA LGLGLLPVL 
AWNCLDGLT TCGVVYPLS KNHLVVLAI AFFMVFGIM LQLYAQICR 
IVCRHAQQI ALQRHRKGI ATLAVVLGA FAACWLPFT VYCLLGDAH 
SPPLYTYLT LLPATYNSM INPIIYAFR NQDVQKVLW AVCC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XBGAOrphanOrphanGPR34Homo sapiensS3E-LysoPS--3.432024-05-1510.1038/s41467-024-45046-z
8XBEAOrphanOrphanGPR34Homo sapiensS3E-LysoPS-Gi1/β1/γ13.42024-05-1510.1038/s41467-024-45046-z
8XBE (No Gprot) AOrphanOrphanGPR34Homo sapiensS3E-LysoPS-3.42024-05-1510.1038/s41467-024-45046-z
8XOGAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92024-04-10To be published
8XOG (No Gprot) AOrphanOrphanGPR30Homo sapiens--2.92024-04-10To be published
8XOJAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.12024-04-10To be published
8XOJ (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.12024-04-10To be published
8XOIAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10To be published
8XOI (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10To be published
8XOHAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10To be published
8XOH (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10To be published
8XOFAOrphanOrphanGPR30Homo sapiensLys05-chim(NtGi1-Gs-CtGq)/β1/γ22.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOF (No Gprot) AOrphanOrphanGPR30Homo sapiensLys05-2.62024-04-10doi.org/10.1038/s41422-024-00963-y
8IZ4AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-Gi1/β1/γ22.942024-04-10To be published
8IZ4 (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-2.942024-04-10To be published
8X2KAOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-chim(NtGi1-Gs)/β1/γ23.032024-04-03To be published
8X2K (No Gprot) AOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-3.032024-04-03To be published
8IYXAOrphanOrphanGPR34Homo sapiensYL-365--3.342024-03-2010.1073/pnas.2308435120
8U8FAOrphanOrphanGPR3Homo sapiensPalmitic Acid-Gs/β1/γ23.492024-03-0610.1021/acs.biochem.3c00647
8U8F (No Gprot) AOrphanOrphanGPR3Homo sapiensPalmitic Acid-3.492024-03-0610.1021/acs.biochem.3c00647
8WW2AOrphanOrphanGPR3Homo sapiens--chim(NtGi1-Gs)/β1/γ22.792024-02-1410.1038/s41422-024-00932-5
8WW2 (No Gprot) AOrphanOrphanGPR3Homo sapiens--2.792024-02-1410.1038/s41422-024-00932-5
8XBIAOrphanOrphanGPR34Homo sapiensS3E-LysoPS--3.062023-12-27To be published
8XBHAOrphanOrphanGPR34Homo sapiensS3E-LysoPS-Gi1/β1/γ22.832023-12-27To be published
8XBH (No Gprot) AOrphanOrphanGPR34Homo sapiensS3E-LysoPS-2.832023-12-27To be published
8WRBAOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-Gi1/β1/γ22.912023-11-0810.1371/journal.pbio.3002387
8WRB (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-2.912023-11-0810.1371/journal.pbio.3002387
8K4NAOrphanOrphanGPR34Homo sapiensVF0-Gi1/β1/γ22.832023-10-25To be published
8K4N (No Gprot) AOrphanOrphanGPR34Homo sapiensVF0-2.832023-10-25To be published
8H8JAOrphanOrphanGPR35Homo sapiensLodoxamideCachim(NtGi1L-G13)/β1/γ23.22023-02-0810.1038/s41421-022-00499-8
8H8J (No Gprot) AOrphanOrphanGPR35Homo sapiensLodoxamideCa3.22023-02-0810.1038/s41421-022-00499-8
8SAIAOrphanOrphanGPR34Homo sapiens1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ23.272023-10-0410.1073/pnas.2308435120
8SAI (No Gprot) AOrphanOrphanGPR34Homo sapiens1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-3.272023-10-0410.1073/pnas.2308435120




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Download 8U8F.zip



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