psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L37	R:R:P38	1.64	No	No	0	1	4
2	R:R:F101	R:R:P38	2.89	Yes	No	0	4	4
3	R:R:P40	R:R:S39	1.78	Yes	No	0	3	2
4	R:R:D44	R:R:P40	4.83	Yes	Yes	3	4	3
5	R:R:F97	R:R:P40	5.78	Yes	Yes	3	5	3
6	R:R:F101	R:R:P40	8.67	Yes	Yes	3	4	3
7	R:R:W43	R:R:Y280	16.4	No	No	0	3	4
8	R:R:D44	R:R:F97	8.36	Yes	Yes	3	4	5
9	R:R:D44	R:R:F101	4.78	Yes	Yes	3	4	4
10	R:R:D44	R:R:Y280	4.6	Yes	No	0	4	4
11	R:R:I49	R:R:V45	3.07	No	No	0	4	5
12	R:R:L47	R:R:Y280	2.34	No	No	0	4	4
13	R:R:C48	R:R:T52	1.69	No	No	0	3	4
14	R:R:C48	R:R:V94	1.71	No	No	0	3	6
15	R:R:C48	R:R:F97	2.79	No	Yes	0	3	5
16	R:R:G51	R:R:S50	1.86	No	No	0	5	5
17	R:R:G51	R:R:V54	1.84	No	Yes	0	5	7
18	R:R:G51	R:R:L93	3.42	No	Yes	0	5	6
19	R:R:L53	R:R:M291	7.07	No	No	0	4	5
20	R:R:N58	R:R:V54	4.43	Yes	Yes	0	9	7
21	R:R:G90	R:R:V54	3.68	No	Yes	0	7	7
22	R:R:S290	R:R:V54	3.23	No	Yes	0	9	7
23	R:R:L91	R:R:S55	6.01	No	No	0	4	6
24	R:R:E57	R:R:M291	2.71	No	No	0	8	5
25	R:R:D86	R:R:N58	10.77	Yes	Yes	0	9	9
26	R:R:L87	R:R:N58	2.75	No	Yes	0	7	9
27	R:R:N58	R:R:P294	6.52	Yes	No	0	9	9
28	R:R:I64	R:R:L60	4.28	No	No	0	8	7
29	R:R:A83	R:R:V61	1.7	No	Yes	0	9	9
30	R:R:P294	R:R:V61	1.77	No	Yes	0	9	9
31	R:R:A298	R:R:V61	1.7	No	Yes	0	7	9
32	R:R:F299	R:R:V61	3.93	No	Yes	0	5	9
33	R:R:A83	R:R:V62	1.7	No	No	0	9	7
34	R:R:V62	R:R:V84	3.21	No	No	0	7	6
35	R:R:G80	R:R:I65	1.76	No	No	0	6	7
36	R:R:G67	R:R:V66	1.84	No	No	0	5	4
37	R:R:P69	R:R:T68	3.5	No	No	0	5	7
38	R:R:A70	R:R:T68	1.68	No	No	0	6	7
39	R:R:F71	R:R:T68	6.49	Yes	No	0	8	7
40	R:R:F71	R:R:F76	20.36	Yes	No	0	8	9
41	R:R:D303	R:R:F71	4.78	No	Yes	0	7	8
42	R:R:F71	R:R:V304	2.62	Yes	No	0	8	8
43	R:R:A73	R:R:P74	1.87	No	No	0	7	5
44	R:R:A73	R:R:F76	2.77	No	No	0	7	9
45	R:R:P74	R:R:T149	3.5	No	No	0	5	8
46	R:R:P74	R:R:T153	6.99	No	No	0	5	6
47	R:R:D133	R:R:M75	6.93	No	No	0	9	8
48	R:R:F76	R:R:N301	2.42	No	No	0	9	8
49	R:R:D133	R:R:L78	4.07	No	Yes	0	9	8
50	R:R:L78	R:R:T153	2.95	Yes	No	0	8	6
51	R:R:L78	R:R:M156	2.83	Yes	No	0	8	5
52	R:R:L157	R:R:L78	2.77	No	Yes	0	7	8
53	R:R:A298	R:R:V79	1.7	No	No	0	7	7
54	R:R:A83	R:R:G80	1.95	No	No	0	9	6
55	R:R:S126	R:R:S81	4.89	No	No	0	8	9
56	R:R:L157	R:R:S81	3	No	No	0	7	9
57	R:R:S81	R:R:W161	6.18	No	No	0	9	9
58	R:R:D86	R:R:L82	2.71	Yes	No	0	9	9
59	R:R:L82	R:R:S126	6.01	No	No	0	9	8
60	R:R:L127	R:R:L82	2.77	No	No	0	8	9
61	R:R:A122	R:R:A85	1.79	No	No	5	7	8
62	R:R:A85	R:R:W161	2.59	No	No	5	8	9
63	R:R:D86	R:R:S290	5.89	Yes	No	0	9	9
64	R:R:D86	R:R:N293	2.69	Yes	No	0	9	9
65	R:R:L87	R:R:L91	2.77	No	No	0	7	4
66	R:R:L88	R:R:V115	4.47	No	No	0	7	4
67	R:R:A119	R:R:L88	4.73	No	No	0	6	7
68	R:R:A119	R:R:A89	1.79	No	No	0	6	8
69	R:R:A89	R:R:F120	2.77	No	No	0	8	4
70	R:R:G92	R:R:L112	1.71	No	No	0	4	5
71	R:R:G92	R:R:L116	1.71	No	No	0	4	5
72	R:R:L93	R:R:T287	2.95	Yes	No	0	6	6
73	R:R:L112	R:R:L95	9.69	No	No	0	5	7
74	R:R:H96	R:R:S109	6.97	No	No	0	5	8
75	R:R:H96	R:R:V113	4.15	No	No	0	5	4
76	R:R:F101	R:R:F97	5.36	Yes	Yes	3	4	5
77	R:R:A98	R:R:C102	1.81	No	No	0	5	5
78	R:R:A99	R:R:M108	3.22	No	No	0	4	4
79	R:R:F101	R:R:V100	3.93	Yes	No	0	4	4
80	R:R:G104	R:R:I103	1.76	No	No	0	3	5
81	R:R:I103	R:R:S105	3.1	No	No	0	5	7
82	R:R:E107	R:R:S105	5.75	No	No	0	1	7
83	R:R:M108	R:R:S105	3.07	No	No	0	4	7
84	R:R:L110	R:R:N176	5.49	No	No	0	5	5
85	R:R:L110	R:R:P189	3.28	No	Yes	0	5	3
86	R:R:G114	R:R:V113	1.84	No	No	0	5	4
87	R:R:P189	R:R:V113	5.3	Yes	No	0	3	4
88	R:R:G114	R:R:P171	4.06	No	No	0	5	5
89	R:R:L165	R:R:M118	2.83	No	No	0	4	4
90	R:R:G168	R:R:M118	1.75	No	No	0	6	4
91	R:R:F120	R:R:S123	2.64	No	No	0	4	9
92	R:R:F120	R:R:W260	6.01	No	Yes	0	4	8
93	R:R:A164	R:R:T121	1.68	No	No	0	8	6
94	R:R:A122	R:R:W161	5.19	No	No	5	7	9
95	R:R:A122	R:R:A164	1.79	No	No	0	7	8
96	R:R:F256	R:R:I124	3.77	Yes	No	1	9	8
97	R:R:I124	R:R:W260	4.7	No	Yes	1	8	8
98	R:R:G125	R:R:V160	3.68	No	No	0	5	6
99	R:R:F256	R:R:L127	2.44	Yes	No	0	9	8
100	R:R:L127	R:R:Y297	4.69	No	Yes	0	8	9
101	R:R:L128	R:R:V132	2.98	No	No	0	7	6
102	R:R:L128	R:R:V205	4.47	No	No	0	7	8
103	R:R:I208	R:R:L128	2.85	No	No	0	5	7
104	R:R:A129	R:R:V160	1.7	No	No	0	6	6
105	R:R:I130	R:R:Y297	6.04	No	Yes	0	9	9
106	R:R:M209	R:R:T131	4.52	No	No	0	8	8
107	R:R:L212	R:R:T131	4.42	No	No	0	6	8
108	R:R:T131	R:R:Y213	9.99	No	Yes	0	8	9
109	R:R:D133	R:R:Y144	4.6	No	Yes	0	9	8
110	R:R:R134	R:R:Y213	2.06	No	Yes	0	9	9
111	R:R:R134	R:R:Y297	4.12	No	Yes	0	9	9
112	R:R:L136	R:R:Y135	2.34	No	Yes	0	5	8
113	R:R:Y135	R:R:Y139	3.97	Yes	No	0	8	6
114	R:R:L212	R:R:Y135	5.86	No	Yes	0	6	8
115	R:R:Q215	R:R:Y135	4.51	No	Yes	0	6	8
116	R:R:L136	R:R:R152	3.64	No	No	0	5	7
117	R:R:S137	R:R:Y144	8.9	No	Yes	0	8	8
118	R:R:I216	R:R:L138	2.85	No	No	0	9	8
119	R:R:N140	R:R:Y139	12.79	No	No	0	5	6
120	R:R:Y144	R:R:Y145	5.96	Yes	No	0	8	4
121	R:R:T149	R:R:Y144	3.75	No	Yes	0	8	8
122	R:R:E147	R:R:S146	2.87	No	No	8	5	4
123	R:R:S146	R:R:T148	3.2	No	No	8	4	6
124	R:R:E147	R:R:T148	4.23	No	No	8	5	6
125	R:R:R152	R:R:T148	6.47	No	No	0	7	6
126	R:R:V150	R:R:Y154	6.31	No	No	0	3	1
127	R:R:G162	R:R:G163	2.11	No	No	0	3	3
128	R:R:G166	R:R:L165	1.71	No	No	0	2	4
129	R:R:G166	R:R:L169	1.71	No	No	0	2	3
130	R:R:L167	R:R:L198	2.77	No	No	0	6	6
131	R:R:L170	R:R:P171	1.64	No	No	4	4	5
132	R:R:L170	R:R:W175	9.11	No	Yes	4	4	4
133	R:R:H194	R:R:L170	11.57	Yes	No	4	7	4
134	R:R:H194	R:R:P171	3.05	Yes	No	4	7	5
135	R:R:L173	R:R:V172	2.98	No	No	0	4	5
136	R:R:S191	R:R:W175	18.53	No	Yes	0	6	4
137	R:R:N193	R:R:W175	9.04	No	Yes	0	3	4
138	R:R:H194	R:R:W175	10.58	Yes	Yes	4	7	4
139	R:R:C177	R:R:T182	1.69	No	No	0	5	4
140	R:R:C177	R:R:C184	5.46	No	No	0	5	9
141	R:R:D179	R:R:G180	3.35	No	No	0	1	3
142	R:R:D179	R:R:L181	4.07	No	No	0	1	2
143	R:R:D179	R:R:T182	5.78	No	No	0	1	4
144	R:R:S191	R:R:T182	4.8	No	No	0	6	4
145	R:R:K192	R:R:T183	3	No	No	0	4	3
146	R:R:G185	R:R:L195	1.71	No	No	0	5	5
147	R:R:V186	R:R:Y266	7.57	No	Yes	2	4	3
148	R:R:G270	R:R:V186	1.84	No	No	2	3	4
149	R:R:T279	R:R:V186	6.35	No	No	2	4	4
150	R:R:P189	R:R:V187	1.77	Yes	No	6	3	5
151	R:R:L190	R:R:V187	2.98	No	No	6	3	5
152	R:R:P189	R:R:Y188	4.17	Yes	No	0	3	5
153	R:R:L190	R:R:P189	3.28	No	Yes	6	3	3
154	R:R:H194	R:R:L198	2.57	Yes	No	0	7	6
155	R:R:C267	R:R:L195	6.35	No	No	0	6	5
156	R:R:A199	R:R:T264	1.68	No	No	0	4	5
157	R:R:F202	R:R:F203	2.14	Yes	No	1	8	4
158	R:R:F202	R:R:F256	8.57	Yes	Yes	1	8	9
159	R:R:F202	R:R:W260	7.02	Yes	Yes	1	8	8
160	R:R:F202	R:R:L261	2.44	Yes	No	0	8	4
161	R:R:F202	R:R:T264	5.19	Yes	No	1	8	5
162	R:R:F203	R:R:T264	6.49	No	No	1	4	5
163	R:R:M209	R:R:V205	3.04	No	No	0	8	8
164	R:R:F206	R:R:L210	2.44	No	No	0	6	4
165	R:R:F206	R:R:F256	4.29	No	Yes	0	6	9
166	R:R:A257	R:R:F206	4.16	No	No	0	5	6
167	R:R:G207	R:R:L210	1.71	No	No	0	4	4
168	R:R:Q211	R:R:Q215	5.12	No	No	0	2	6
169	R:R:I216	R:R:Y213	3.63	No	Yes	0	9	9
170	R:R:L249	R:R:Y213	3.52	No	Yes	0	7	9
171	R:R:V252	R:R:Y213	2.52	No	Yes	7	7	9
172	R:R:L253	R:R:Y213	4.69	No	Yes	7	7	9
173	R:R:H223	R:R:I219	2.65	No	No	0	7	6
174	R:R:H223	R:R:R222	7.9	No	No	0	7	5
175	R:R:A224	R:R:T242	1.68	No	No	0	5	7
176	R:R:H232	R:R:I227	9.28	No	No	0	3	7
177	R:R:I246	R:R:R243	7.52	No	No	0	7	5
178	R:R:G245	R:R:K244	1.74	No	No	0	8	8
179	R:R:R300	R:R:T248	2.59	No	No	0	7	8
180	R:R:I296	R:R:V251	3.07	No	No	0	8	6
181	R:R:L253	R:R:V252	2.98	No	No	7	7	7
182	R:R:F256	R:R:W260	2	Yes	Yes	1	9	8
183	R:R:C259	R:R:P285	3.77	No	No	0	8	7
184	R:R:C259	R:R:N289	6.3	No	No	0	8	9
185	R:R:A286	R:R:W260	7.78	No	Yes	0	6	8
186	R:R:N289	R:R:W260	4.52	No	Yes	0	9	8
187	R:R:L261	R:R:P262	1.64	No	No	0	4	9
188	R:R:P262	R:R:T282	1.75	No	No	0	9	8
189	R:R:C267	R:R:F263	6.98	No	No	0	6	6
190	R:R:F263	R:R:L283	3.65	No	No	0	6	4
191	R:R:G270	R:R:Y266	4.35	No	Yes	2	3	3
192	R:R:S274	R:R:Y266	6.36	No	Yes	2	3	3
193	R:R:Y266	R:R:Y278	7.94	Yes	No	2	3	3
194	R:R:T279	R:R:Y266	4.99	No	Yes	2	4	3
195	R:R:T282	R:R:Y266	2.5	No	Yes	0	8	3
196	R:R:D271	R:R:H273	3.78	No	No	0	4	3
197	R:R:P275	R:R:S274	5.34	No	No	0	3	3
198	R:R:S274	R:R:Y278	6.36	No	No	2	3	3
199	R:R:P275	R:R:P276	1.95	No	No	0	3	2
200	R:R:L284	R:R:P285	1.64	No	No	0	4	7
201	R:R:L284	R:R:Y288	4.69	No	No	0	4	4
202	R:R:N289	R:R:N293	10.9	No	No	0	9	9
203	R:R:I292	R:R:I296	2.94	No	No	0	5	8
204	R:R:I296	R:R:Y297	4.84	No	Yes	0	8	9
205	R:R:N301	R:R:V304	2.96	No	No	0	8	8
206	R:R:Q302	R:R:Q305	6.4	No	No	0	5	8
207	R:R:A310	R:R:K306	3.21	No	No	0	4	5
208	R:R:C312	R:R:W309	2.61	No	No	0	5	4
209	R:R:C312	R:R:C313	1.82	No	No	0	5	4
210	R:R:S50	R:R:V46	1.62	No	No	0	5	4
211	R:R:S126	R:R:V160	1.62	No	No	0	8	6
212	R:R:A255	R:R:I292	1.62	No	No	0	6	5
213	R:R:A164	R:R:M118	1.61	No	No	0	8	4
214	R:R:V111	R:R:V115	1.6	No	No	0	4	4
215	R:R:V307	R:R:V311	1.6	No	No	0	8	5
216	R:R:T151	R:R:V155	1.59	No	No	0	4	3
217	R:R:C217	R:R:L249	1.59	No	No	0	6	7
218	R:R:T248	R:R:V252	1.59	No	No	0	8	7
219	R:R:A59	R:R:L87	1.58	No	No	0	5	7
220	R:R:A174	R:R:L173	1.58	No	No	0	4	4
221	R:R:A199	R:R:L268	1.58	No	No	0	4	5
222	R:R:E57	R:R:P294	1.57	No	No	0	8	9
223	R:R:I200	R:R:V196	1.54	No	No	0	4	3
224	R:R:I216	R:R:V220	1.54	No	No	0	9	8
225	R:R:A272	R:R:D271	1.54	No	No	0	3	4
226	R:R:L95	R:R:V94	1.49	No	No	0	7	6
227	R:R:L110	R:R:V172	1.49	No	No	0	5	5
228	R:R:L159	R:R:V155	1.49	No	No	0	2	3
229	R:R:L169	R:R:V172	1.49	No	No	0	3	5
230	R:R:L269	R:R:V265	1.49	No	No	0	4	6
231	R:R:N140	R:R:T143	1.46	No	No	0	5	5
232	R:R:I49	R:R:L53	1.43	No	No	0	4	4
233	R:R:I64	R:R:L308	1.43	No	No	0	8	5
234	R:R:I219	R:R:L138	1.43	No	No	0	6	8
235	R:R:L112	R:R:M108	1.41	No	No	0	5	4
236	R:R:D44	R:R:K41	1.38	Yes	No	0	4	3
237	R:R:L47	R:R:L93	1.38	No	Yes	0	4	6
238	R:R:L284	R:R:L47	1.38	No	No	0	4	4
239	R:R:L116	R:R:L93	1.38	No	Yes	0	5	6
240	R:R:L190	R:R:L195	1.38	No	No	0	3	5
241	R:R:H194	R:R:V197	1.38	Yes	No	0	7	5
242	R:R:A247	R:R:R243	1.38	No	No	0	8	5
243	R:R:L268	R:R:L269	1.38	No	No	0	5	4
244	R:R:L277	R:R:L281	1.38	No	No	0	4	4
245	R:R:E57	R:R:I295	1.37	No	No	0	8	5
246	R:R:N301	R:R:Q302	1.32	No	No	0	8	5
247	R:R:F203	R:R:I200	1.26	No	No	0	4	4
248	R:R:H223	R:R:Q226	1.24	No	No	0	7	5
249	R:R:F299	R:R:L60	1.22	No	No	0	5	7
250	R:R:Q215	R:R:R218	1.17	No	No	0	6	4
251	R:R:L277	R:R:Y278	1.17	No	No	0	4	3
252	R:R:F71	R:R:R72	1.07	Yes	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P40	5.265	4	3	3
2	R:R:D44	4.79	5	3	4
3	R:R:V54	3.295	4	0	7
4	R:R:N58	6.1175	4	0	9
5	R:R:V61	2.275	4	0	9
6	R:R:F71	7.064	5	0	8
7	R:R:L78	3.155	4	0	8
8	R:R:D86	5.515	4	0	9
9	R:R:L93	2.2825	4	0	6
10	R:R:F97	5.5725	4	3	5
11	R:R:F101	5.126	5	3	4
12	R:R:Y135	4.17	4	0	8
13	R:R:Y144	5.8025	4	0	8
14	R:R:W175	11.815	4	4	4
15	R:R:P189	3.56	5	6	3
16	R:R:H194	5.83	5	4	7
17	R:R:F202	5.072	5	1	8
18	R:R:Y213	4.40167	6	7	9
19	R:R:F256	4.214	5	1	9
20	R:R:W260	5.33833	6	1	8
21	R:R:Y266	5.61833	6	2	3
22	R:R:Y297	4.9225	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D44	R:R:F101	10.2338	4.78	Yes	Yes	3	4	4
2	R:R:D44	R:R:Y280	28.6434	4.6	Yes	No	0	4	4
3	R:R:E57	R:R:P294	10.1988	1.57	No	No	0	8	9
4	R:R:N58	R:R:P294	30.4984	6.52	Yes	No	0	9	9
5	R:R:N58	R:R:V54	36.3433	4.43	Yes	Yes	0	9	7
6	R:R:G51	R:R:V54	61.7528	1.84	No	Yes	0	5	7
7	R:R:G51	R:R:L93	53.9829	3.42	No	Yes	0	5	6
8	R:R:L47	R:R:L93	31.5694	1.38	No	Yes	0	4	6
9	R:R:L47	R:R:Y280	33.5433	2.34	No	No	0	4	4
10	R:R:S290	R:R:V54	30.8904	3.23	No	Yes	0	9	7
11	R:R:D86	R:R:N58	62.3408	10.77	Yes	Yes	0	9	9
12	R:R:D86	R:R:S290	31.9754	5.89	Yes	No	0	9	9
13	R:R:P294	R:R:V61	19.8166	1.77	No	Yes	0	9	9
14	R:R:D86	R:R:L82	89.3112	2.71	Yes	No	0	9	9
15	R:R:L82	R:R:S126	100	6.01	No	No	0	9	8
16	R:R:S126	R:R:S81	97.2841	4.89	No	No	0	8	9
17	R:R:L157	R:R:S81	40.2632	3	No	No	0	7	9
18	R:R:L157	R:R:L78	38.8072	2.77	No	Yes	0	7	8
19	R:R:L78	R:R:T153	26.2775	2.95	Yes	No	0	8	6
20	R:R:P74	R:R:T153	24.7235	6.99	No	No	0	5	6
21	R:R:A73	R:R:P74	21.9796	1.87	No	No	0	7	5
22	R:R:A73	R:R:F76	20.3486	2.77	No	No	0	7	9
23	R:R:F71	R:R:F76	11.9978	20.36	Yes	No	0	8	9
24	R:R:S81	R:R:W161	74.2755	6.18	No	No	0	9	9
25	R:R:L127	R:R:L82	79.0564	2.77	No	No	0	8	9
26	R:R:F256	R:R:L127	45.4151	2.44	Yes	No	0	9	8
27	R:R:F256	R:R:W260	14.6857	2	Yes	Yes	1	9	8
28	R:R:N289	R:R:W260	22.0146	4.52	No	Yes	0	9	8
29	R:R:C259	R:R:N289	16.2257	6.3	No	No	0	8	9
30	R:R:C259	R:R:P285	15.1057	3.77	No	No	0	8	7
31	R:R:L284	R:R:P285	14.0137	1.64	No	No	0	4	7
32	R:R:L284	R:R:L47	12.4598	1.38	No	No	0	4	4
33	R:R:A122	R:R:W161	71.7556	5.19	No	No	5	7	9
34	R:R:N289	R:R:N293	12.0188	10.9	No	No	0	9	9
35	R:R:F120	R:R:W260	10.9198	6.01	No	Yes	0	4	8
36	R:R:G92	R:R:L112	21.0276	1.71	No	No	0	4	5
37	R:R:G92	R:R:L116	23.3375	1.71	No	No	0	4	5
38	R:R:L116	R:R:L93	25.6615	1.38	No	Yes	0	5	6
39	R:R:P189	R:R:V113	44.6591	5.3	Yes	No	0	3	4
40	R:R:L110	R:R:P189	56.6149	3.28	No	Yes	0	5	3
41	R:R:L110	R:R:V172	59.1698	1.49	No	No	0	5	5
42	R:R:L169	R:R:V172	62.8657	1.49	No	No	0	3	5
43	R:R:G166	R:R:L169	64.0697	1.71	No	No	0	2	3
44	R:R:G166	R:R:L165	65.2597	1.71	No	No	0	2	4
45	R:R:L165	R:R:M118	66.4357	2.83	No	No	0	4	4
46	R:R:A164	R:R:M118	68.7456	1.61	No	No	0	8	4
47	R:R:A122	R:R:A164	70.9996	1.79	No	No	0	7	8
48	R:R:L112	R:R:M108	14.9027	1.41	No	No	0	5	4
49	R:R:G114	R:R:V113	40.4732	1.84	No	No	0	5	4
50	R:R:G114	R:R:P171	39.0172	4.06	No	No	0	5	5
51	R:R:L127	R:R:Y297	64.3637	4.69	No	Yes	0	8	9
52	R:R:T131	R:R:Y213	33.3823	9.99	No	Yes	0	8	9
53	R:R:R134	R:R:Y213	54.6829	2.06	No	Yes	0	9	9
54	R:R:R134	R:R:Y297	56.0129	4.12	No	Yes	0	9	9
55	R:R:L212	R:R:T131	23.3445	4.42	No	No	0	6	8
56	R:R:L212	R:R:Y135	21.6086	5.86	No	Yes	0	6	8
57	R:R:I216	R:R:Y213	12.9007	3.63	No	Yes	0	9	9
58	R:R:H194	R:R:P171	21.1606	3.05	Yes	No	4	7	5
59	R:R:L170	R:R:P171	16.3727	1.64	No	No	4	4	5
60	R:R:L170	R:R:W175	14.7977	9.11	No	Yes	4	4	4
61	R:R:H194	R:R:W175	14.9867	10.58	Yes	Yes	4	7	4
62	R:R:S191	R:R:W175	23.2675	18.53	No	Yes	0	6	4
63	R:R:S191	R:R:T182	19.9846	4.8	No	No	0	6	4
64	R:R:D179	R:R:T182	10.0518	5.78	No	No	0	1	4
65	R:R:L190	R:R:P189	10.3808	3.28	No	Yes	6	3	3
66	R:R:F202	R:R:W260	12.1588	7.02	Yes	Yes	1	8	8
67	R:R:F202	R:R:L261	23.1065	2.44	Yes	No	0	8	4
68	R:R:L261	R:R:P262	21.4126	1.64	No	No	0	4	9
69	R:R:P262	R:R:T282	19.7046	1.75	No	No	0	9	8
70	R:R:T282	R:R:Y266	17.9826	2.5	No	Yes	0	8	3
71	R:R:D86	R:R:N293	12.9217	2.69	Yes	No	0	9	9
72	R:R:F202	R:R:F256	25.5565	8.57	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8WW2_nogp

PDB Summary
PDB	8WW2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.64
Number of Linked Nodes	246
Number of Links	252
Number of Hubs	22
Number of Links mediated by Hubs	89
Number of Communities	8
Number of Nodes involved in Communities	32
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	30433
Length Of Smallest Path	3
Average Path Length	15.5427
Length of Longest Path	34
Minimum Path Strength	1.275
Average Path Strength	3.94621
Maximum Path Strength	14.555
Minimum Path Correlation	0.7
Average Path Correlation	0.9291
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	46.5754
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	26.316
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process • multicellular organismal process • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of cellular component organization • sexual reproduction • regulation of reproductive process • reproductive process • meiotic cell cycle process • cellular component organization • meiotic nuclear division • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • cell cycle process • regulation of meiotic cell cycle • regulation of cell cycle process • meiotic cell cycle • organelle fission • regulation of organelle organization • regulation of meiotic nuclear division • organelle organization • nuclear division • regulation of nuclear division • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • ionotropic glutamate receptor binding • glutamate receptor binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • D1 dopamine receptor binding • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase activator activity • insulin-like growth factor receptor binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • regulation of microtubule-based process • regulation of spindle organization • mitotic spindle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • developmental growth • growth • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • apical part of cell • plasma membrane region • apical plasma membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46089
Sequence	>8WW2_nogp_Chain_R L P S P K A W D V V L C I S G T L V S C E N A L V V A I I V G T P A F R A P M F L L V G S L A V A D L L A G L G L V L H F A A V F C I G S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N A L T Y Y S E T T V T R T Y V M L A L V W G G A L G L G L L P V L A W N C L D G L T T C G V V Y P L S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A Q Q I A L Q R H T R K G I A T L A V V L G A F A A C W L P F T V Y C L L G D A H S P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D V Q K V L W A V C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8H8J	A	Orphan	Orphan	GPR35	Homo sapiens	Lodoxamide	Ca	chim(NtGi1L-G13)/β1/γ2	3.2	2023-02-08	doi.org/10.1038/s41421-022-00499-8
	8H8J (No Gprot)	A	Orphan	Orphan	GPR35	Homo sapiens	Lodoxamide	Ca		3.2	2023-02-08	doi.org/10.1038/s41421-022-00499-8
	8U8F	A	Orphan	Orphan	GPR3	Homo sapiens	Palmitic Acid	-	Gs/β1/γ2	3.49	2024-03-06	doi.org/10.1021/acs.biochem.3c00647
	8U8F (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	Palmitic Acid	-		3.49	2024-03-06	doi.org/10.1021/acs.biochem.3c00647
	8WW2	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.79	2024-02-14	doi.org/10.1038/s41422-024-00932-5
	8WW2 (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	-	-		2.79	2024-02-14	doi.org/10.1038/s41422-024-00932-5
	9LYB	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYB (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	-	-		3.16	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYC	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	Gs/β1/γ2	3.06	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYC (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	-	-		3.06	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	9LYD	A	Orphan	Orphan	GPR3	Homo sapiens	-	-	-	3.66	2025-04-09	doi.org/10.1016/j.celrep.2025.115478
	8X2K	A	Orphan	Orphan	GPR3	Homo sapiens	Oleic monoethanolamide	-	chim(NtGi1-Gs)/β1/γ2	3.03	2024-04-03	doi.org/10.1038/s41422-023-00919-8
	8X2K (No Gprot)	A	Orphan	Orphan	GPR3	Homo sapiens	Oleic monoethanolamide	-		3.03	2024-04-03	doi.org/10.1038/s41422-023-00919-8
	8XOF	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOF (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-		2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOG	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOG (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		2.9	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOH	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOH (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOI	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOI (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOJ	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOJ (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.1	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XBE	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ1	3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBE (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBG	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.43	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8SAI	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-	Gi1/β1/γ2	3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8SAI (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-		3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8IYX	A	Orphan	Orphan	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	doi.org/10.1073/pnas.2308435120
	8WRB	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8WRB (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8XBH	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ2	2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBH (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBI	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.06	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8K4N	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-	Gi1/β1/γ2	2.83	2023-10-25	To be published
	8K4N (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-		2.83	2023-10-25	To be published
	8IZ4	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.94	2024-04-10	To be published
	8IZ4 (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.94	2024-04-10	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8WW2_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.