psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T132	4.94	Yes	No	0	0	5
2	L:L:?1	R:R:Y135	20.28	Yes	Yes	1	0	5
3	L:L:?1	R:R:M136	7.1	Yes	Yes	1	0	5
4	L:L:?1	R:R:M189	4.73	Yes	No	1	0	4
5	L:L:?1	R:R:R208	18.98	Yes	No	0	0	5
6	L:L:?1	R:R:F219	7.48	Yes	No	1	0	5
7	L:L:?1	R:R:N220	6.13	Yes	No	1	0	4
8	L:L:?1	R:R:L223	8.5	Yes	No	1	0	5
9	L:L:?1	R:R:R286	4.75	Yes	Yes	1	0	6
10	L:L:?1	R:R:Y289	5.89	Yes	Yes	1	0	4
11	L:L:?1	R:R:N309	7.66	Yes	Yes	1	0	5
12	R:R:C299	R:R:C46	7.28	No	No	0	7	6
13	R:R:E50	R:R:M48	9.47	No	No	0	4	2
14	R:R:E303	R:R:M48	4.06	No	No	0	1	2
15	R:R:D49	R:R:K51	13.83	No	No	0	4	4
16	R:R:E50	R:R:N118	5.26	No	No	0	4	4
17	R:R:L52	R:R:L53	4.15	No	No	0	4	5
18	R:R:K307	R:R:L53	14.1	No	No	0	3	5
19	R:R:L57	R:R:Y61	4.69	Yes	Yes	0	5	8
20	R:R:H114	R:R:L57	5.14	Yes	Yes	2	5	5
21	R:R:E310	R:R:L57	7.95	No	Yes	2	5	5
22	R:R:H114	R:R:T58	4.11	Yes	No	0	5	5
23	R:R:I115	R:R:T58	9.12	No	No	0	4	5
24	R:R:S60	R:R:V314	6.46	No	No	0	5	5
25	R:R:R110	R:R:Y61	9.26	No	Yes	0	7	8
26	R:R:L313	R:R:Y61	3.52	Yes	Yes	0	5	8
27	R:R:V314	R:R:Y61	5.05	No	Yes	0	5	8
28	R:R:S317	R:R:Y61	3.82	No	Yes	0	7	8
29	R:R:I111	R:R:S62	7.74	No	No	0	7	6
30	R:R:I64	R:R:S317	4.64	No	No	0	7	7
31	R:R:F318	R:R:I64	6.28	No	No	0	5	7
32	R:R:F65	R:R:I104	3.77	No	No	0	7	5
33	R:R:F65	R:R:L107	3.65	No	No	0	7	7
34	R:R:F65	R:R:P108	5.78	No	No	0	7	9
35	R:R:C321	R:R:V67	6.83	No	No	0	7	6
36	R:R:G68	R:R:I104	3.53	No	No	0	8	5
37	R:R:I73	R:R:L69	4.28	No	No	0	3	6
38	R:R:I104	R:R:L69	4.28	No	No	0	5	6
39	R:R:G71	R:R:P324	4.06	No	Yes	0	8	9
40	R:R:D100	R:R:N72	6.73	Yes	No	0	9	9
41	R:R:N72	R:R:P324	6.52	No	Yes	0	9	9
42	R:R:F328	R:R:I74	6.28	Yes	No	0	6	5
43	R:R:A75	R:R:P324	3.74	No	Yes	0	8	9
44	R:R:L76	R:R:L80	4.15	No	No	0	7	3
45	R:R:F79	R:R:L93	4.87	No	No	3	6	8
46	R:R:F79	R:R:L94	3.65	No	No	0	6	6
47	R:R:F79	R:R:Y327	7.22	No	No	3	6	9
48	R:R:L80	R:R:R86	3.64	No	No	0	3	7
49	R:R:H83	R:R:I82	5.3	No	No	0	5	5
50	R:R:H83	R:R:Q90	8.65	No	No	0	5	7
51	R:R:I91	R:R:R86	5.01	No	No	0	6	7
52	R:R:L94	R:R:R86	3.64	No	No	0	6	7
53	R:R:N87	R:R:Q90	9.24	No	No	0	8	7
54	R:R:K155	R:R:N87	4.2	No	No	0	8	8
55	R:R:D151	R:R:S88	4.42	Yes	No	0	8	6
56	R:R:S88	R:R:T167	6.4	No	No	0	6	6
57	R:R:D151	R:R:I89	11.2	Yes	No	0	8	7
58	R:R:I89	R:R:R152	5.01	No	No	0	7	9
59	R:R:I89	R:R:K155	5.82	No	No	0	7	8
60	R:R:I91	R:R:S171	4.64	No	No	0	6	7
61	R:R:I172	R:R:I91	4.42	No	No	0	4	6
62	R:R:F147	R:R:Y92	13.41	No	Yes	4	5	7
63	R:R:I148	R:R:Y92	4.84	No	Yes	0	9	7
64	R:R:D151	R:R:Y92	4.6	Yes	Yes	0	8	7
65	R:R:S171	R:R:Y92	7.63	No	Yes	0	7	7
66	R:R:V174	R:R:Y92	6.31	No	Yes	4	5	7
67	R:R:I148	R:R:L93	4.28	No	No	0	9	8
68	R:R:L93	R:R:Y327	4.69	No	No	3	8	9
69	R:R:C175	R:R:N95	7.87	No	No	0	6	9
70	R:R:D100	R:R:V96	4.38	Yes	No	0	9	9
71	R:R:L144	R:R:V96	4.47	No	No	0	7	9
72	R:R:D100	R:R:S141	4.42	Yes	No	0	9	9
73	R:R:D100	R:R:S320	11.78	Yes	No	0	9	8
74	R:R:D100	R:R:D323	3.99	Yes	No	0	9	9
75	R:R:F105	R:R:L101	3.65	No	No	0	5	7
76	R:R:L102	R:R:N137	10.98	No	No	0	7	8
77	R:R:L103	R:R:L107	4.15	No	No	0	7	7
78	R:R:F134	R:R:L103	7.31	No	No	0	7	7
79	R:R:L103	R:R:S320	4.5	No	No	0	7	8
80	R:R:C106	R:R:L133	4.76	No	Yes	0	6	5
81	R:R:F109	R:R:V130	7.87	No	No	0	6	5
82	R:R:H114	R:R:R110	4.51	Yes	No	0	5	7
83	R:R:F205	R:R:R110	28.86	Yes	No	0	4	7
84	R:R:H114	R:R:Y113	10.89	Yes	No	0	5	5
85	R:R:W120	R:R:Y113	3.86	Yes	No	0	9	5
86	R:R:F205	R:R:Y113	8.25	Yes	No	0	4	5
87	R:R:H114	R:R:N118	5.1	Yes	No	0	5	4
88	R:R:E310	R:R:H114	4.92	No	Yes	2	5	5
89	R:R:K119	R:R:Q117	9.49	No	No	0	4	3
90	R:R:L122	R:R:W120	5.69	Yes	Yes	0	7	9
91	R:R:C127	R:R:W120	5.22	No	Yes	5	9	9
92	R:R:C204	R:R:W120	5.22	No	Yes	5	9	9
93	R:R:L122	R:R:T121	4.42	Yes	No	0	7	3
94	R:R:I125	R:R:L194	5.71	No	Yes	0	1	4
95	R:R:C127	R:R:C204	7.28	No	No	5	9	9
96	R:R:K128	R:R:T193	6.01	No	No	0	8	5
97	R:R:F205	R:R:V130	3.93	Yes	No	0	4	5
98	R:R:F186	R:R:T132	6.49	Yes	No	0	7	5
99	R:R:L133	R:R:M136	4.24	Yes	Yes	1	5	5
100	R:R:L133	R:R:N137	4.12	Yes	No	1	5	8
101	R:R:F186	R:R:L133	4.87	Yes	Yes	0	7	5
102	R:R:F134	R:R:Y135	11.35	No	Yes	0	7	5
103	R:R:Y135	R:R:Y282	5.96	Yes	Yes	1	5	6
104	R:R:R286	R:R:Y135	4.12	Yes	Yes	1	6	5
105	R:R:L313	R:R:Y135	5.86	Yes	Yes	1	5	5
106	R:R:M136	R:R:N137	7.01	Yes	No	1	5	8
107	R:R:M138	R:R:Y139	4.79	No	Yes	0	7	7
108	R:R:I142	R:R:Y139	3.63	Yes	Yes	0	8	7
109	R:R:L223	R:R:Y139	19.93	No	Yes	0	5	7
110	R:R:H283	R:R:Y139	6.53	Yes	Yes	0	8	7
111	R:R:I140	R:R:W179	8.22	Yes	No	0	7	9
112	R:R:F227	R:R:I142	8.79	Yes	Yes	1	8	8
113	R:R:F279	R:R:I142	8.79	Yes	Yes	1	8	8
114	R:R:F275	R:R:L145	3.65	Yes	No	0	9	8
115	R:R:D323	R:R:L145	6.79	No	No	0	9	8
116	R:R:G146	R:R:I234	3.53	No	Yes	0	7	8
117	R:R:F147	R:R:V174	6.55	No	No	4	5	5
118	R:R:I148	R:R:R152	7.52	No	No	0	9	9
119	R:R:I234	R:R:S149	10.84	Yes	No	0	8	9
120	R:R:S149	R:R:S237	6.52	No	No	0	9	6
121	R:R:S149	R:R:Y238	5.09	No	Yes	0	9	8
122	R:R:L150	R:R:L233	4.15	No	No	0	5	7
123	R:R:R152	R:R:Y238	8.23	No	Yes	0	9	8
124	R:R:N157	R:R:Y153	11.63	No	Yes	0	7	7
125	R:R:S237	R:R:Y153	3.82	No	Yes	0	6	7
126	R:R:K240	R:R:Y153	9.55	No	Yes	0	4	7
127	R:R:I241	R:R:Y153	3.63	Yes	Yes	0	8	7
128	R:R:I156	R:R:I241	4.42	No	Yes	0	8	8
129	R:R:N157	R:R:N244	13.62	No	No	0	7	5
130	R:R:Q170	R:R:T167	4.25	No	No	0	3	6
131	R:R:K169	R:R:Y173	15.53	No	No	0	4	2
132	R:R:F186	R:R:L187	3.65	Yes	No	0	7	4
133	R:R:F186	R:R:I190	5.02	Yes	No	0	7	5
134	R:R:F219	R:R:M189	8.71	No	No	1	5	4
135	R:R:I191	R:R:K195	5.82	No	No	0	4	4
136	R:R:K196	R:R:L192	5.64	No	No	0	3	4
137	R:R:K195	R:R:L194	4.23	No	Yes	0	4	4
138	R:R:H199	R:R:N212	6.38	No	No	0	3	2
139	R:R:H206	R:R:M203	3.94	No	No	0	5	4
140	R:R:C204	R:R:F205	9.78	No	Yes	0	9	4
141	R:R:H206	R:R:R208	7.9	No	No	0	5	5
142	R:R:Y207	R:R:Y289	7.94	No	Yes	1	3	4
143	R:R:Q293	R:R:Y207	9.02	No	No	1	4	3
144	R:R:K302	R:R:Y207	14.33	Yes	No	0	4	3
145	R:R:K210	R:R:R208	4.95	No	No	0	3	5
146	R:R:D209	R:R:H211	8.82	No	No	0	5	4
147	R:R:K210	R:R:Q293	13.56	No	No	0	3	4
148	R:R:G215	R:R:I218	3.53	No	No	0	3	5
149	R:R:A217	R:R:L294	4.73	No	No	0	4	1
150	R:R:F219	R:R:L223	3.65	No	No	1	5	5
151	R:R:N220	R:R:R286	16.87	No	Yes	1	4	6
152	R:R:I290	R:R:N220	7.08	No	No	1	5	4
153	R:R:F221	R:R:V225	3.93	No	No	0	4	5
154	R:R:F221	R:R:F287	5.36	No	No	0	4	6
155	R:R:H283	R:R:V224	4.15	Yes	No	0	8	4
156	R:R:F287	R:R:V224	7.87	No	No	0	6	4
157	R:R:F227	R:R:W228	5.01	Yes	No	1	8	5
158	R:R:F227	R:R:F279	5.36	Yes	Yes	1	8	8
159	R:R:F227	R:R:H283	37.33	Yes	Yes	1	8	8
160	R:R:H283	R:R:W228	4.23	Yes	No	1	8	5
161	R:R:F231	R:R:F275	6.43	No	Yes	0	7	9
162	R:R:F231	R:R:T276	7.78	No	No	7	7	5
163	R:R:F231	R:R:V280	7.87	No	No	7	7	5
164	R:R:F275	R:R:I234	7.54	Yes	Yes	0	9	8
165	R:R:I235	R:R:L272	5.71	No	Yes	0	4	7
166	R:R:S268	R:R:Y238	6.36	No	Yes	0	7	8
167	R:R:V271	R:R:Y238	10.09	No	Yes	0	7	8
168	R:R:L272	R:R:Y238	4.69	Yes	Yes	0	7	8
169	R:R:I239	R:R:K243	4.36	No	No	0	3	4
170	R:R:G242	R:R:I241	3.53	No	Yes	6	4	8
171	R:R:I241	R:R:S268	4.64	Yes	No	6	8	7
172	R:R:G242	R:R:S268	3.71	No	No	6	4	7
173	R:R:F269	R:R:G242	4.52	No	No	0	4	4
174	R:R:N244	R:R:R247	3.62	No	No	0	5	5
175	R:R:I248	R:R:N244	5.66	No	No	0	6	5
176	R:R:F269	R:R:L246	3.65	No	No	0	4	3
177	R:R:R247	R:R:R251	4.26	No	No	0	5	4
178	R:R:I248	R:R:Y261	3.63	No	No	0	6	6
179	R:R:K254	R:R:P256	6.69	No	No	0	4	3
180	R:R:F255	R:R:P256	4.33	No	No	0	3	3
181	R:R:K260	R:R:N257	5.6	No	No	0	5	4
182	R:R:N257	R:R:Y261	8.14	No	No	0	4	6
183	R:R:N267	R:R:T263	4.39	No	No	0	7	7
184	R:R:N267	R:R:R266	3.62	No	No	0	7	6
185	R:R:I270	R:R:R266	5.01	No	No	0	5	6
186	R:R:M330	R:R:N267	14.02	No	No	0	6	7
187	R:R:M326	R:R:V271	6.09	No	No	0	7	7
188	R:R:I274	R:R:M326	7.29	No	No	0	6	7
189	R:R:F275	R:R:F279	12.86	Yes	Yes	0	9	8
190	R:R:T276	R:R:V280	6.35	No	No	7	5	5
191	R:R:C278	R:R:N319	9.45	No	No	0	7	9
192	R:R:F279	R:R:S316	5.28	Yes	No	0	8	7
193	R:R:F279	R:R:N319	12.08	Yes	No	0	8	9
194	R:R:P281	R:R:V280	5.3	No	No	0	9	5
195	R:R:H283	R:R:Y282	14.16	Yes	Yes	1	8	6
196	R:R:R286	R:R:Y282	12.35	Yes	Yes	1	6	6
197	R:R:M312	R:R:Y282	5.99	No	Yes	0	6	6
198	R:R:L313	R:R:Y282	7.03	Yes	Yes	1	5	6
199	R:R:S316	R:R:Y282	5.09	No	Yes	0	7	6
200	R:R:F285	R:R:I288	6.28	No	No	0	5	5
201	R:R:F285	R:R:V305	6.55	No	No	0	5	4
202	R:R:F285	R:R:T308	20.75	No	No	0	5	5
203	R:R:R286	R:R:Y289	10.29	Yes	Yes	1	6	4
204	R:R:I290	R:R:R286	5.01	No	Yes	1	5	6
205	R:R:N309	R:R:R286	4.82	Yes	Yes	1	5	6
206	R:R:Q293	R:R:Y289	6.76	No	Yes	1	4	4
207	R:R:V305	R:R:Y289	3.79	No	Yes	0	4	4
208	R:R:N309	R:R:Y289	18.61	Yes	Yes	1	5	4
209	R:R:S292	R:R:W301	3.71	No	No	0	3	1
210	R:R:K302	R:R:S297	4.59	Yes	No	0	4	2
211	R:R:E303	R:R:Y300	6.73	No	No	0	1	2
212	R:R:I304	R:R:W301	5.87	No	No	0	3	1
213	R:R:V305	R:R:W301	6.13	No	No	0	4	1
214	R:R:E310	R:R:H306	8.62	No	No	0	5	4
215	R:R:L313	R:R:N309	5.49	Yes	Yes	1	5	5
216	R:R:C321	R:R:F318	5.59	No	No	0	7	5
217	R:R:F318	R:R:L322	13.4	No	No	0	5	6
218	R:R:D323	R:R:N319	4.04	No	No	0	9	9
219	R:R:F328	R:R:P324	4.33	Yes	Yes	0	6	9
220	R:R:N333	R:R:S331	5.96	No	No	8	6	8
221	R:R:I334	R:R:S331	6.19	Yes	No	8	8	8
222	R:R:R335	R:R:S332	5.27	No	No	0	8	5
223	R:R:I334	R:R:N333	5.66	Yes	No	8	8	6
224	R:R:I337	R:R:Q340	4.12	No	No	0	4	4
225	R:R:L342	R:R:M338	4.24	No	No	0	5	5
226	R:R:L341	R:R:Q340	3.99	No	No	0	4	4
227	R:R:M112	R:R:W120	3.49	No	Yes	0	4	9
228	R:R:N95	R:R:W179	3.39	No	No	0	9	9
229	R:R:I111	R:R:P108	3.39	No	No	0	7	9
230	R:R:L315	R:R:P281	3.28	No	No	0	7	9
231	R:R:A99	R:R:I140	3.25	No	Yes	0	8	7
232	R:R:A182	R:R:I140	3.25	No	Yes	0	7	7
233	R:R:C299	R:R:K302	3.23	No	Yes	0	7	4
234	R:R:A217	R:R:K210	3.21	No	No	0	4	3
235	R:R:A265	R:R:L245	3.15	No	No	0	5	8
236	R:R:A265	R:R:L246	3.15	No	No	0	5	3
237	R:R:I82	R:R:V78	3.07	No	No	0	5	7
238	R:R:I190	R:R:V129	3.07	No	No	0	5	5
239	R:R:K128	R:R:V124	3.04	No	No	0	8	4
240	R:R:A213	R:R:E216	3.02	No	Yes	0	1	3
241	R:R:N118	R:R:S54	2.98	No	No	0	4	5
242	R:R:L245	R:R:T264	2.95	No	No	0	8	7
243	R:R:I142	R:R:I230	2.94	Yes	Yes	1	8	9
244	R:R:I143	R:R:I230	2.94	No	Yes	1	5	9
245	R:R:I230	R:R:I234	2.94	Yes	Yes	0	9	8
246	R:R:I140	R:R:M136	2.92	Yes	Yes	0	7	5
247	R:R:I143	R:R:M226	2.92	No	No	1	5	5
248	R:R:I230	R:R:M226	2.92	Yes	No	1	9	5
249	R:R:I166	R:R:K164	2.91	No	No	0	7	3
250	R:R:M326	R:R:M330	2.89	No	No	0	7	6
251	R:R:K307	R:R:M48	2.88	No	No	0	3	2
252	L:L:?1	R:R:G131	2.86	Yes	No	0	0	6
253	R:R:I190	R:R:L194	2.85	No	Yes	0	5	4
254	R:R:I239	R:R:L272	2.85	No	Yes	0	3	7
255	R:R:I273	R:R:L272	2.85	No	Yes	0	4	7
256	R:R:L183	R:R:M136	2.83	No	Yes	0	4	5
257	R:R:K128	R:R:L194	2.82	No	Yes	0	8	4
258	R:R:K214	R:R:L294	2.82	No	No	0	2	1
259	R:R:D151	R:R:I154	2.8	Yes	No	0	8	6
260	R:R:D209	R:R:K302	2.77	No	Yes	0	5	4
261	R:R:H211	R:R:V296	2.77	No	No	0	4	1
262	R:R:L232	R:R:L236	2.77	No	No	0	2	4
263	R:R:R252	R:R:S258	2.64	No	No	0	4	4
264	R:R:R163	R:R:T167	2.59	No	No	0	5	6
265	R:R:Q161	R:R:Q162	2.56	No	No	0	4	5
266	R:R:S249	R:R:Y261	2.54	No	No	0	3	6
267	R:R:I98	R:R:W179	2.35	No	No	0	5	9
268	L:L:?1	R:R:L181	2.32	Yes	No	0	0	4
269	R:R:G184	R:R:G185	2.11	No	No	0	3	4
270	R:R:G197	R:R:G198	2.11	No	No	0	1	1
271	R:R:R158	R:R:Y153	2.06	No	Yes	0	5	7
272	L:L:?1	R:R:G185	1.91	Yes	No	0	0	4
273	R:R:C46	R:R:P47	1.88	No	No	0	6	2
274	R:R:G71	R:R:V70	1.84	No	No	0	8	4
275	R:R:G185	R:R:T188	1.82	No	No	0	4	8
276	R:R:A75	R:R:A97	1.79	No	No	0	8	9
277	R:R:G81	R:R:I82	1.76	No	No	0	4	5
278	R:R:G123	R:R:L122	1.71	No	Yes	0	7	7
279	R:R:A262	R:R:S249	1.71	No	No	0	5	3
280	R:R:C176	R:R:I172	1.64	No	No	0	4	4
281	R:R:E216	R:R:G215	1.64	Yes	No	0	3	3
282	R:R:C278	R:R:I277	1.64	No	No	0	7	5
283	R:R:S249	R:R:S258	1.63	No	No	0	3	4
284	R:R:N257	R:R:P256	1.63	No	No	0	4	3
285	R:R:C176	R:R:M180	1.62	No	No	0	4	4
286	R:R:A165	R:R:K85	1.61	No	No	0	3	6
287	R:R:V63	R:R:V67	1.6	No	No	0	5	6
288	R:R:V174	R:R:V178	1.6	No	No	0	5	7
289	R:R:T55	R:R:V56	1.59	No	No	0	5	5
290	R:R:I66	R:R:V67	1.54	No	No	0	5	6
291	R:R:I222	R:R:V225	1.54	No	No	0	5	5
292	R:R:M203	R:R:S201	1.53	No	No	0	4	4
293	R:R:K254	R:R:S253	1.53	No	No	0	4	3
294	R:R:I172	R:R:T168	1.52	No	No	0	4	4
295	R:R:M203	R:R:T202	1.51	No	No	0	4	4
296	R:R:L53	R:R:V56	1.49	No	No	0	5	5
297	R:R:L57	R:R:V56	1.49	Yes	No	0	5	5
298	R:R:L329	R:R:V325	1.49	No	No	0	6	6
299	R:R:N200	R:R:V124	1.48	No	No	0	5	4
300	R:R:I334	R:R:I337	1.47	Yes	No	0	8	4
301	R:R:N116	R:R:T121	1.46	No	No	0	3	3
302	R:R:I311	R:R:L57	1.43	No	Yes	0	5	5
303	R:R:I73	R:R:L101	1.43	No	No	0	3	7
304	R:R:I235	R:R:L236	1.43	No	No	0	4	4
305	R:R:E216	R:R:T193	1.41	Yes	No	0	3	5
306	R:R:K85	R:R:N87	1.4	No	No	0	6	8
307	R:R:L122	R:R:L126	1.38	Yes	No	0	7	5
308	R:R:L341	R:R:L342	1.38	No	No	0	4	5
309	R:R:D49	R:R:L52	1.36	No	No	0	4	4
310	R:R:E216	R:R:L192	1.33	Yes	No	0	3	4
311	R:R:N116	R:R:Q117	1.32	No	No	0	3	3
312	R:R:A284	R:R:W228	1.3	No	No	0	6	5
313	R:R:S298	R:R:Y300	1.27	No	No	0	5	2
314	R:R:V78	R:R:Y77	1.26	No	No	0	7	4
315	R:R:F328	R:R:I334	1.26	Yes	Yes	0	6	8
316	R:R:F328	R:R:L329	1.22	Yes	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.395	14	1	0
2	R:R:L57	4.14	5	2	5
3	R:R:Y61	5.268	5	0	8
4	R:R:Y92	7.358	5	4	7
5	R:R:D100	6.26	5	0	9
6	R:R:H114	5.77833	6	2	5
7	R:R:W120	4.696	5	5	9
8	R:R:L122	3.3	4	0	7
9	R:R:L133	4.4975	4	1	5
10	R:R:Y135	9.514	5	1	5
11	R:R:M136	4.82	5	1	5
12	R:R:Y139	8.72	4	0	7
13	R:R:I140	4.41	4	0	7
14	R:R:I142	6.0375	4	1	8
15	R:R:D151	5.755	4	0	8
16	R:R:Y153	6.138	5	0	7
17	R:R:F186	5.0075	4	0	7
18	R:R:L194	3.9025	4	0	4
19	R:R:F205	12.705	4	0	4
20	R:R:E216	1.85	4	0	3
21	R:R:F227	14.1225	4	1	8
22	R:R:I230	2.935	4	1	9
23	R:R:I234	6.2125	4	0	8
24	R:R:Y238	6.892	5	0	8
25	R:R:I241	4.055	4	6	8
26	R:R:L272	4.025	4	0	7
27	R:R:F275	7.62	4	0	9
28	R:R:F279	8.874	5	1	8
29	R:R:Y282	8.43	6	1	6
30	R:R:H283	13.28	5	1	8
31	R:R:R286	8.31571	7	1	6
32	R:R:Y289	8.88	6	1	4
33	R:R:K302	6.23	4	0	4
34	R:R:N309	9.145	4	1	5
35	R:R:L313	5.475	4	1	5
36	R:R:P324	4.6625	4	0	9
37	R:R:F328	3.2725	4	0	6
38	R:R:I334	3.645	4	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y289	11.7532	5.89	Yes	Yes	1	0	4
2	R:R:Y207	R:R:Y289	14.2831	7.94	No	Yes	1	3	4
3	R:R:K302	R:R:Y207	13.0956	14.33	Yes	No	0	4	3
4	L:L:?1	R:R:Y135	31.4869	20.28	Yes	Yes	1	0	5
5	R:R:L313	R:R:Y135	30.9006	5.86	Yes	Yes	1	5	5
6	R:R:L313	R:R:Y61	100	3.52	Yes	Yes	0	5	8
7	R:R:L57	R:R:Y61	40.0649	4.69	Yes	Yes	0	5	8
8	R:R:H114	R:R:L57	23.7609	5.14	Yes	Yes	2	5	5
9	R:R:H114	R:R:N118	16.8646	5.1	Yes	No	0	5	4
10	R:R:E50	R:R:N118	12.1146	5.26	No	No	0	4	4
11	L:L:?1	R:R:N309	17.7681	7.66	Yes	Yes	1	0	5
12	R:R:L313	R:R:N309	26.512	5.49	Yes	Yes	1	5	5
13	R:R:R110	R:R:Y61	51.4862	9.26	No	Yes	0	7	8
14	R:R:H114	R:R:R110	23.3036	4.51	Yes	No	0	5	7
15	R:R:L57	R:R:V56	13.5049	1.49	Yes	No	0	5	5
16	R:R:L53	R:R:V56	11.0267	1.49	No	No	0	5	5
17	R:R:E303	R:R:M48	10.739	4.06	No	No	0	1	2
18	R:R:S317	R:R:Y61	11.2664	3.82	No	Yes	0	7	8
19	R:R:F134	R:R:Y135	26.9214	11.35	No	Yes	0	7	5
20	R:R:F134	R:R:L103	25.8998	7.31	No	No	0	7	7
21	R:R:L103	R:R:L107	14.2757	4.15	No	No	0	7	7
22	R:R:F65	R:R:L107	13.0145	3.65	No	No	0	7	7
23	R:R:L103	R:R:S320	21.9612	4.5	No	No	0	7	8
24	R:R:D100	R:R:S320	21.6736	11.78	Yes	No	0	9	8
25	R:R:D100	R:R:N72	21.6256	6.73	Yes	No	0	9	9
26	R:R:N72	R:R:P324	20.475	6.52	No	Yes	0	9	9
27	R:R:F328	R:R:P324	14.6002	4.33	Yes	Yes	0	6	9
28	L:L:?1	R:R:L223	28.994	8.5	Yes	No	1	0	5
29	R:R:L223	R:R:Y139	29.2005	19.93	No	Yes	0	5	7
30	R:R:I142	R:R:Y139	31.4833	3.63	Yes	Yes	0	8	7
31	R:R:I142	R:R:I230	34.2012	2.94	Yes	Yes	1	8	9
32	R:R:I230	R:R:I234	30.3843	2.94	Yes	Yes	0	9	8
33	R:R:I234	R:R:S149	86.0783	10.84	Yes	No	0	8	9
34	R:R:S149	R:R:Y238	67.5173	5.09	No	Yes	0	9	8
35	R:R:R152	R:R:Y238	47.7062	8.23	No	Yes	0	9	8
36	R:R:I148	R:R:R152	26.0179	7.52	No	No	0	9	9
37	R:R:I148	R:R:Y92	16.2782	4.84	No	Yes	0	9	7
38	R:R:S171	R:R:Y92	11.8675	7.63	No	Yes	0	7	7
39	R:R:I91	R:R:S171	10.5731	4.64	No	No	0	6	7
40	R:R:I89	R:R:R152	20.9618	5.01	No	No	0	7	9
41	R:R:I89	R:R:K155	13.1325	5.82	No	No	0	7	8
42	R:R:K155	R:R:N87	11.8343	4.2	No	No	0	8	8
43	L:L:?1	R:R:M136	20.5561	7.1	Yes	Yes	1	0	5
44	R:R:I140	R:R:M136	11.6905	2.92	Yes	Yes	0	7	5
45	R:R:D100	R:R:D323	15.2751	3.99	Yes	No	0	9	9
46	R:R:S316	R:R:Y282	51.3166	5.09	No	Yes	0	7	6
47	R:R:F279	R:R:S316	50.8998	5.28	Yes	No	0	8	7
48	R:R:R286	R:R:Y282	14.8694	12.35	Yes	Yes	1	6	6
49	R:R:F205	R:R:R110	27.8544	28.86	Yes	No	0	4	7
50	R:R:H114	R:R:Y113	24.1887	10.89	Yes	No	0	5	5
51	R:R:F205	R:R:Y113	11.897	8.25	Yes	No	0	4	5
52	R:R:W120	R:R:Y113	31.9627	3.86	Yes	No	0	9	5
53	R:R:C204	R:R:F205	12.9333	9.78	No	Yes	0	9	4
54	R:R:C204	R:R:W120	10.5362	5.22	No	Yes	5	9	9
55	R:R:L122	R:R:W120	32.9363	5.69	Yes	Yes	0	7	9
56	R:R:L122	R:R:T121	18.8634	4.42	Yes	No	0	7	3
57	R:R:N116	R:R:T121	14.1577	1.46	No	No	0	3	3
58	L:L:?1	R:R:T132	29.9344	4.94	Yes	No	0	0	5
59	R:R:F186	R:R:T132	28.3965	6.49	Yes	No	0	7	5
60	R:R:F186	R:R:I190	26.1027	5.02	Yes	No	0	7	5
61	R:R:I190	R:R:L194	22.9311	2.85	No	Yes	0	5	4
62	R:R:K128	R:R:L194	16.4995	2.82	No	Yes	0	8	4
63	R:R:K128	R:R:T193	11.5983	6.01	No	No	0	8	5
64	R:R:H283	R:R:Y282	11.8048	14.16	Yes	Yes	1	8	6
65	R:R:F275	R:R:F279	50.8814	12.86	Yes	Yes	0	9	8
66	R:R:F275	R:R:L145	14.3126	3.65	Yes	No	0	9	8
67	R:R:S149	R:R:S237	25.8814	6.52	No	No	0	9	6
68	R:R:S237	R:R:Y153	24.7787	3.82	No	Yes	0	6	7
69	R:R:N157	R:R:Y153	23.0491	11.63	No	Yes	0	7	7
70	R:R:S268	R:R:Y238	14.5892	6.36	No	Yes	0	7	8
71	R:R:N157	R:R:N244	21.6477	13.62	No	No	0	7	5
72	L:L:?1	R:R:R208	14.567	18.98	Yes	No	0	0	5
73	R:R:H283	R:R:V224	11.0415	4.15	Yes	No	0	8	4
74	R:R:V271	R:R:Y238	10.7095	10.09	No	Yes	0	7	8
75	R:R:I248	R:R:N244	17.4915	5.66	No	No	0	6	5
76	R:R:I248	R:R:Y261	16.0643	3.63	No	No	0	6	6
77	R:R:V305	R:R:Y289	11.3549	3.79	No	Yes	0	4	4
78	R:R:R286	R:R:Y289	10.492	10.29	Yes	Yes	1	6	4
79	R:R:F275	R:R:I234	57.9768	7.54	Yes	Yes	0	9	8
80	R:R:L313	R:R:Y282	44.3981	7.03	Yes	Yes	1	5	6
81	R:R:D323	R:R:L145	13.055	6.79	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T132	4.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y135	20.28	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M136	7.1	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M189	4.73	1	Yes	No	0	4	0	1
L:L:?1	R:R:R208	18.98	1	Yes	No	0	5	0	1
L:L:?1	R:R:F219	7.48	1	Yes	No	0	5	0	1
L:L:?1	R:R:N220	6.13	1	Yes	No	0	4	0	1
L:L:?1	R:R:L223	8.5	1	Yes	No	0	5	0	1
L:L:?1	R:R:R286	4.75	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y289	5.89	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:N309	7.66	1	Yes	Yes	0	5	0	1
R:R:F186	R:R:T132	6.49	0	Yes	No	7	5	2	1
R:R:L133	R:R:M136	4.24	1	Yes	Yes	5	5	2	1
R:R:L133	R:R:N137	4.12	1	Yes	No	5	8	2	2
R:R:F186	R:R:L133	4.87	0	Yes	Yes	7	5	2	2
R:R:F134	R:R:Y135	11.35	0	No	Yes	7	5	2	1
R:R:Y135	R:R:Y282	5.96	1	Yes	Yes	5	6	1	2
R:R:R286	R:R:Y135	4.12	1	Yes	Yes	6	5	1	1
R:R:L313	R:R:Y135	5.86	1	Yes	Yes	5	5	2	1
R:R:M136	R:R:N137	7.01	1	Yes	No	5	8	1	2
R:R:L223	R:R:Y139	19.93	1	No	Yes	5	7	1	2
R:R:F219	R:R:M189	8.71	1	No	No	5	4	1	1
R:R:H206	R:R:R208	7.9	0	No	No	5	5	2	1
R:R:Y207	R:R:Y289	7.94	1	No	Yes	3	4	2	1
R:R:Q293	R:R:Y207	9.02	1	No	No	4	3	2	2
R:R:K210	R:R:R208	4.95	0	No	No	3	5	2	1
R:R:K210	R:R:Q293	13.56	0	No	No	3	4	2	2
R:R:F219	R:R:L223	3.65	1	No	No	5	5	1	1
R:R:N220	R:R:R286	16.87	1	No	Yes	4	6	1	1
R:R:I290	R:R:N220	7.08	1	No	No	5	4	2	1
R:R:R286	R:R:Y282	12.35	1	Yes	Yes	6	6	1	2
R:R:L313	R:R:Y282	7.03	1	Yes	Yes	5	6	2	2
R:R:R286	R:R:Y289	10.29	1	Yes	Yes	6	4	1	1
R:R:I290	R:R:R286	5.01	1	No	Yes	5	6	2	1
R:R:N309	R:R:R286	4.82	1	Yes	Yes	5	6	1	1
R:R:Q293	R:R:Y289	6.76	1	No	Yes	4	4	2	1
R:R:V305	R:R:Y289	3.79	0	No	Yes	4	4	2	1
R:R:N309	R:R:Y289	18.61	1	Yes	Yes	5	4	1	1
R:R:L313	R:R:N309	5.49	1	Yes	Yes	5	5	2	1
R:R:I140	R:R:M136	2.92	0	Yes	Yes	7	5	2	1
L:L:?1	R:R:G131	2.86	1	Yes	No	0	6	0	1
R:R:L183	R:R:M136	2.83	0	No	Yes	4	5	2	1
L:L:?1	R:R:L181	2.32	1	Yes	No	0	4	0	1
R:R:G184	R:R:G185	2.11	0	No	No	3	4	2	1
L:L:?1	R:R:G185	1.91	1	Yes	No	0	4	0	1
R:R:G185	R:R:T188	1.82	0	No	No	4	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XBH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	286
Number of Links	316
Number of Hubs	38
Number of Links mediated by Hubs	145
Number of Communities	8
Number of Nodes involved in Communities	46
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	62466
Length Of Smallest Path	3
Average Path Length	12.8125
Length of Longest Path	27
Minimum Path Strength	1.24
Average Path Strength	6.86381
Maximum Path Strength	25.745
Minimum Path Correlation	0.7
Average Path Correlation	0.939639
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	54.4669
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.2716
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KW3
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KW3
Name	(2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid
Synonyms
Identifier
Formula	C30 H36 N O11 P
Molecular Weight	617.581
SMILES
PubChem	162656636
Formal Charge	0
Total Atoms	79
Total Chiral Atoms	2
Total Bonds	81
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UPC5
Sequence	>8XBH_nogp_Chain_R T C P M D E K L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H R K R N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q N K W T L G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S I Q Q R K A I T T K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G G H N S T M C F H Y R D K H N A K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K R R S K F P N S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S Q L N V S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N I R K I M C Q L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XBE	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ1	3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBE (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBG	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.43	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8SAI	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-	Gi1/β1/γ2	3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8SAI (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-		3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8IYX	A	Orphan	Orphan	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	doi.org/10.1073/pnas.2308435120
	8WRB	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8WRB (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8XBH	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ2	2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBH (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBI	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.06	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8K4N	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-	Gi1/β1/γ2	2.83	2023-10-25	To be published
	8K4N (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-		2.83	2023-10-25	To be published
	8IZ4	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.94	2024-04-10	To be published
	8IZ4 (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.94	2024-04-10	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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