psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T132	4.94	Yes	No	0	0	5
2	L:L:?1	R:R:Y135	20.28	Yes	Yes	1	0	5
3	L:L:?1	R:R:M136	7.1	Yes	Yes	1	0	5
4	L:L:?1	R:R:M189	4.73	Yes	No	1	0	4
5	L:L:?1	R:R:R208	18.98	Yes	No	0	0	5
6	L:L:?1	R:R:F219	7.48	Yes	No	1	0	5
7	L:L:?1	R:R:N220	6.13	Yes	No	1	0	4
8	L:L:?1	R:R:L223	8.5	Yes	No	1	0	5
9	L:L:?1	R:R:R286	4.75	Yes	Yes	1	0	6
10	L:L:?1	R:R:Y289	5.89	Yes	Yes	1	0	4
11	L:L:?1	R:R:N309	7.66	Yes	Yes	1	0	5
12	R:R:C299	R:R:C46	7.28	No	No	0	7	6
13	R:R:E50	R:R:M48	9.47	No	No	0	4	2
14	R:R:E303	R:R:M48	4.06	No	No	0	1	2
15	R:R:D49	R:R:K51	13.83	No	No	0	4	4
16	R:R:E50	R:R:N118	5.26	No	No	0	4	4
17	R:R:L52	R:R:L53	4.15	No	No	0	4	5
18	R:R:K307	R:R:L53	14.1	No	No	0	3	5
19	R:R:L57	R:R:Y61	4.69	Yes	Yes	0	5	8
20	R:R:H114	R:R:L57	5.14	Yes	Yes	2	5	5
21	R:R:E310	R:R:L57	7.95	No	Yes	2	5	5
22	R:R:H114	R:R:T58	4.11	Yes	No	0	5	5
23	R:R:I115	R:R:T58	9.12	No	No	0	4	5
24	R:R:S60	R:R:V314	6.46	No	No	0	5	5
25	R:R:R110	R:R:Y61	9.26	No	Yes	0	7	8
26	R:R:L313	R:R:Y61	3.52	Yes	Yes	0	5	8
27	R:R:V314	R:R:Y61	5.05	No	Yes	0	5	8
28	R:R:S317	R:R:Y61	3.82	No	Yes	0	7	8
29	R:R:I111	R:R:S62	7.74	No	No	0	7	6
30	R:R:I64	R:R:S317	4.64	No	No	0	7	7
31	R:R:F318	R:R:I64	6.28	No	No	0	5	7
32	R:R:F65	R:R:I104	3.77	No	No	0	7	5
33	R:R:F65	R:R:L107	3.65	No	No	0	7	7
34	R:R:F65	R:R:P108	5.78	No	No	0	7	9
35	R:R:C321	R:R:V67	6.83	No	No	0	7	6
36	R:R:G68	R:R:I104	3.53	No	No	0	8	5
37	R:R:I73	R:R:L69	4.28	No	No	0	3	6
38	R:R:I104	R:R:L69	4.28	No	No	0	5	6
39	R:R:G71	R:R:P324	4.06	No	Yes	0	8	9
40	R:R:D100	R:R:N72	6.73	Yes	No	0	9	9
41	R:R:N72	R:R:P324	6.52	No	Yes	0	9	9
42	R:R:F328	R:R:I74	6.28	Yes	No	0	6	5
43	R:R:A75	R:R:P324	3.74	No	Yes	0	8	9
44	R:R:L76	R:R:L80	4.15	No	No	0	7	3
45	R:R:F79	R:R:L93	4.87	No	No	3	6	8
46	R:R:F79	R:R:L94	3.65	No	No	0	6	6
47	R:R:F79	R:R:Y327	7.22	No	No	3	6	9
48	R:R:L80	R:R:R86	3.64	No	No	0	3	7
49	R:R:H83	R:R:I82	5.3	No	No	0	5	5
50	R:R:H83	R:R:Q90	8.65	No	No	0	5	7
51	R:R:I91	R:R:R86	5.01	No	No	0	6	7
52	R:R:L94	R:R:R86	3.64	No	No	0	6	7
53	R:R:N87	R:R:Q90	9.24	No	No	0	8	7
54	R:R:K155	R:R:N87	4.2	No	No	0	8	8
55	R:R:D151	R:R:S88	4.42	Yes	No	0	8	6
56	R:R:S88	R:R:T167	6.4	No	No	0	6	6
57	R:R:D151	R:R:I89	11.2	Yes	No	0	8	7
58	R:R:I89	R:R:R152	5.01	No	No	0	7	9
59	R:R:I89	R:R:K155	5.82	No	No	0	7	8
60	R:R:I91	R:R:S171	4.64	No	No	0	6	7
61	R:R:I172	R:R:I91	4.42	No	No	0	4	6
62	R:R:F147	R:R:Y92	13.41	No	Yes	4	5	7
63	R:R:I148	R:R:Y92	4.84	No	Yes	0	9	7
64	R:R:D151	R:R:Y92	4.6	Yes	Yes	0	8	7
65	R:R:S171	R:R:Y92	7.63	No	Yes	0	7	7
66	R:R:V174	R:R:Y92	6.31	No	Yes	4	5	7
67	R:R:I148	R:R:L93	4.28	No	No	0	9	8
68	R:R:L93	R:R:Y327	4.69	No	No	3	8	9
69	R:R:C175	R:R:N95	7.87	No	No	0	6	9
70	R:R:D100	R:R:V96	4.38	Yes	No	0	9	9
71	R:R:L144	R:R:V96	4.47	No	No	0	7	9
72	R:R:D100	R:R:S141	4.42	Yes	No	0	9	9
73	R:R:D100	R:R:S320	11.78	Yes	No	0	9	8
74	R:R:D100	R:R:D323	3.99	Yes	No	0	9	9
75	R:R:F105	R:R:L101	3.65	No	No	0	5	7
76	R:R:L102	R:R:N137	10.98	No	No	0	7	8
77	R:R:L103	R:R:L107	4.15	No	No	0	7	7
78	R:R:F134	R:R:L103	7.31	No	No	0	7	7
79	R:R:L103	R:R:S320	4.5	No	No	0	7	8
80	R:R:C106	R:R:L133	4.76	No	Yes	0	6	5
81	R:R:F109	R:R:V130	7.87	No	No	0	6	5
82	R:R:H114	R:R:R110	4.51	Yes	No	0	5	7
83	R:R:F205	R:R:R110	28.86	Yes	No	0	4	7
84	R:R:H114	R:R:Y113	10.89	Yes	No	0	5	5
85	R:R:W120	R:R:Y113	3.86	Yes	No	0	9	5
86	R:R:F205	R:R:Y113	8.25	Yes	No	0	4	5
87	R:R:H114	R:R:N118	5.1	Yes	No	0	5	4
88	R:R:E310	R:R:H114	4.92	No	Yes	2	5	5
89	R:R:K119	R:R:Q117	9.49	No	No	0	4	3
90	R:R:L122	R:R:W120	5.69	Yes	Yes	0	7	9
91	R:R:C127	R:R:W120	5.22	No	Yes	5	9	9
92	R:R:C204	R:R:W120	5.22	No	Yes	5	9	9
93	R:R:L122	R:R:T121	4.42	Yes	No	0	7	3
94	R:R:I125	R:R:L194	5.71	No	Yes	0	1	4
95	R:R:C127	R:R:C204	7.28	No	No	5	9	9
96	R:R:K128	R:R:T193	6.01	No	No	0	8	5
97	R:R:F205	R:R:V130	3.93	Yes	No	0	4	5
98	R:R:F186	R:R:T132	6.49	Yes	No	0	7	5
99	R:R:L133	R:R:M136	4.24	Yes	Yes	1	5	5
100	R:R:L133	R:R:N137	4.12	Yes	No	1	5	8
101	R:R:F186	R:R:L133	4.87	Yes	Yes	0	7	5
102	R:R:F134	R:R:Y135	11.35	No	Yes	0	7	5
103	R:R:Y135	R:R:Y282	5.96	Yes	Yes	1	5	6
104	R:R:R286	R:R:Y135	4.12	Yes	Yes	1	6	5
105	R:R:L313	R:R:Y135	5.86	Yes	Yes	1	5	5
106	R:R:M136	R:R:N137	7.01	Yes	No	1	5	8
107	R:R:M138	R:R:Y139	4.79	No	Yes	0	7	7
108	R:R:I142	R:R:Y139	3.63	Yes	Yes	0	8	7
109	R:R:L223	R:R:Y139	19.93	No	Yes	0	5	7
110	R:R:H283	R:R:Y139	6.53	Yes	Yes	0	8	7
111	R:R:I140	R:R:W179	8.22	Yes	No	0	7	9
112	R:R:F227	R:R:I142	8.79	Yes	Yes	1	8	8
113	R:R:F279	R:R:I142	8.79	Yes	Yes	1	8	8
114	R:R:F275	R:R:L145	3.65	Yes	No	0	9	8
115	R:R:D323	R:R:L145	6.79	No	No	0	9	8
116	R:R:G146	R:R:I234	3.53	No	Yes	0	7	8
117	R:R:F147	R:R:V174	6.55	No	No	4	5	5
118	R:R:I148	R:R:R152	7.52	No	No	0	9	9
119	R:R:I234	R:R:S149	10.84	Yes	No	0	8	9
120	R:R:S149	R:R:S237	6.52	No	No	0	9	6
121	R:R:S149	R:R:Y238	5.09	No	Yes	0	9	8
122	R:R:L150	R:R:L233	4.15	No	No	0	5	7
123	R:R:R152	R:R:Y238	8.23	No	Yes	0	9	8
124	R:R:N157	R:R:Y153	11.63	No	Yes	0	7	7
125	R:R:S237	R:R:Y153	3.82	No	Yes	0	6	7
126	R:R:K240	R:R:Y153	9.55	No	Yes	0	4	7
127	R:R:I241	R:R:Y153	3.63	Yes	Yes	0	8	7
128	R:R:I156	R:R:I241	4.42	No	Yes	0	8	8
129	R:R:N157	R:R:N244	13.62	No	No	0	7	5
130	R:R:Q170	R:R:T167	4.25	No	No	0	3	6
131	R:R:K169	R:R:Y173	15.53	No	No	0	4	2
132	R:R:F186	R:R:L187	3.65	Yes	No	0	7	4
133	R:R:F186	R:R:I190	5.02	Yes	No	0	7	5
134	R:R:F219	R:R:M189	8.71	No	No	1	5	4
135	R:R:I191	R:R:K195	5.82	No	No	0	4	4
136	R:R:K196	R:R:L192	5.64	No	No	0	3	4
137	R:R:K195	R:R:L194	4.23	No	Yes	0	4	4
138	R:R:H199	R:R:N212	6.38	No	No	0	3	2
139	R:R:H206	R:R:M203	3.94	No	No	0	5	4
140	R:R:C204	R:R:F205	9.78	No	Yes	0	9	4
141	R:R:H206	R:R:R208	7.9	No	No	0	5	5
142	R:R:Y207	R:R:Y289	7.94	No	Yes	1	3	4
143	R:R:Q293	R:R:Y207	9.02	No	No	1	4	3
144	R:R:K302	R:R:Y207	14.33	Yes	No	0	4	3
145	R:R:K210	R:R:R208	4.95	No	No	0	3	5
146	R:R:D209	R:R:H211	8.82	No	No	0	5	4
147	R:R:K210	R:R:Q293	13.56	No	No	0	3	4
148	R:R:G215	R:R:I218	3.53	No	No	0	3	5
149	R:R:A217	R:R:L294	4.73	No	No	0	4	1
150	R:R:F219	R:R:L223	3.65	No	No	1	5	5
151	R:R:N220	R:R:R286	16.87	No	Yes	1	4	6
152	R:R:I290	R:R:N220	7.08	No	No	1	5	4
153	R:R:F221	R:R:V225	3.93	No	No	0	4	5
154	R:R:F221	R:R:F287	5.36	No	No	0	4	6
155	R:R:H283	R:R:V224	4.15	Yes	No	0	8	4
156	R:R:F287	R:R:V224	7.87	No	No	0	6	4
157	R:R:F227	R:R:W228	5.01	Yes	No	1	8	5
158	R:R:F227	R:R:F279	5.36	Yes	Yes	1	8	8
159	R:R:F227	R:R:H283	37.33	Yes	Yes	1	8	8
160	R:R:H283	R:R:W228	4.23	Yes	No	1	8	5
161	R:R:F231	R:R:F275	6.43	No	Yes	0	7	9
162	R:R:F231	R:R:T276	7.78	No	No	7	7	5
163	R:R:F231	R:R:V280	7.87	No	No	7	7	5
164	R:R:F275	R:R:I234	7.54	Yes	Yes	0	9	8
165	R:R:I235	R:R:L272	5.71	No	Yes	0	4	7
166	R:R:S268	R:R:Y238	6.36	No	Yes	0	7	8
167	R:R:V271	R:R:Y238	10.09	No	Yes	0	7	8
168	R:R:L272	R:R:Y238	4.69	Yes	Yes	0	7	8
169	R:R:I239	R:R:K243	4.36	No	No	0	3	4
170	R:R:G242	R:R:I241	3.53	No	Yes	6	4	8
171	R:R:I241	R:R:S268	4.64	Yes	No	6	8	7
172	R:R:G242	R:R:S268	3.71	No	No	6	4	7
173	R:R:F269	R:R:G242	4.52	No	No	0	4	4
174	R:R:N244	R:R:R247	3.62	No	No	0	5	5
175	R:R:I248	R:R:N244	5.66	No	No	0	6	5
176	R:R:F269	R:R:L246	3.65	No	No	0	4	3
177	R:R:R247	R:R:R251	4.26	No	No	0	5	4
178	R:R:I248	R:R:Y261	3.63	No	No	0	6	6
179	R:R:K254	R:R:P256	6.69	No	No	0	4	3
180	R:R:F255	R:R:P256	4.33	No	No	0	3	3
181	R:R:K260	R:R:N257	5.6	No	No	0	5	4
182	R:R:N257	R:R:Y261	8.14	No	No	0	4	6
183	R:R:N267	R:R:T263	4.39	No	No	0	7	7
184	R:R:N267	R:R:R266	3.62	No	No	0	7	6
185	R:R:I270	R:R:R266	5.01	No	No	0	5	6
186	R:R:M330	R:R:N267	14.02	No	No	0	6	7
187	R:R:M326	R:R:V271	6.09	No	No	0	7	7
188	R:R:I274	R:R:M326	7.29	No	No	0	6	7
189	R:R:F275	R:R:F279	12.86	Yes	Yes	0	9	8
190	R:R:T276	R:R:V280	6.35	No	No	7	5	5
191	R:R:C278	R:R:N319	9.45	No	No	0	7	9
192	R:R:F279	R:R:S316	5.28	Yes	No	0	8	7
193	R:R:F279	R:R:N319	12.08	Yes	No	0	8	9
194	R:R:P281	R:R:V280	5.3	No	No	0	9	5
195	R:R:H283	R:R:Y282	14.16	Yes	Yes	1	8	6
196	R:R:R286	R:R:Y282	12.35	Yes	Yes	1	6	6
197	R:R:M312	R:R:Y282	5.99	No	Yes	0	6	6
198	R:R:L313	R:R:Y282	7.03	Yes	Yes	1	5	6
199	R:R:S316	R:R:Y282	5.09	No	Yes	0	7	6
200	R:R:F285	R:R:I288	6.28	No	No	0	5	5
201	R:R:F285	R:R:V305	6.55	No	No	0	5	4
202	R:R:F285	R:R:T308	20.75	No	No	0	5	5
203	R:R:R286	R:R:Y289	10.29	Yes	Yes	1	6	4
204	R:R:I290	R:R:R286	5.01	No	Yes	1	5	6
205	R:R:N309	R:R:R286	4.82	Yes	Yes	1	5	6
206	R:R:Q293	R:R:Y289	6.76	No	Yes	1	4	4
207	R:R:V305	R:R:Y289	3.79	No	Yes	0	4	4
208	R:R:N309	R:R:Y289	18.61	Yes	Yes	1	5	4
209	R:R:S292	R:R:W301	3.71	No	No	0	3	1
210	R:R:K302	R:R:S297	4.59	Yes	No	0	4	2
211	R:R:E303	R:R:Y300	6.73	No	No	0	1	2
212	R:R:I304	R:R:W301	5.87	No	No	0	3	1
213	R:R:V305	R:R:W301	6.13	No	No	0	4	1
214	R:R:E310	R:R:H306	8.62	No	No	0	5	4
215	R:R:L313	R:R:N309	5.49	Yes	Yes	1	5	5
216	R:R:C321	R:R:F318	5.59	No	No	0	7	5
217	R:R:F318	R:R:L322	13.4	No	No	0	5	6
218	R:R:D323	R:R:N319	4.04	No	No	0	9	9
219	R:R:F328	R:R:P324	4.33	Yes	Yes	0	6	9
220	R:R:N333	R:R:S331	5.96	No	No	8	6	8
221	R:R:I334	R:R:S331	6.19	Yes	No	8	8	8
222	R:R:R335	R:R:S332	5.27	No	No	0	8	5
223	R:R:I334	R:R:N333	5.66	Yes	No	8	8	6
224	R:R:I337	R:R:Q340	4.12	No	No	0	4	4
225	R:R:L342	R:R:M338	4.24	No	No	0	5	5
226	R:R:L341	R:R:Q340	3.99	No	No	0	4	4
227	R:R:M112	R:R:W120	3.49	No	Yes	0	4	9
228	R:R:N95	R:R:W179	3.39	No	No	0	9	9
229	R:R:I111	R:R:P108	3.39	No	No	0	7	9
230	R:R:L315	R:R:P281	3.28	No	No	0	7	9
231	R:R:A99	R:R:I140	3.25	No	Yes	0	8	7
232	R:R:A182	R:R:I140	3.25	No	Yes	0	7	7
233	R:R:C299	R:R:K302	3.23	No	Yes	0	7	4
234	R:R:A217	R:R:K210	3.21	No	No	0	4	3
235	R:R:A265	R:R:L245	3.15	No	No	0	5	8
236	R:R:A265	R:R:L246	3.15	No	No	0	5	3
237	R:R:I82	R:R:V78	3.07	No	No	0	5	7
238	R:R:I190	R:R:V129	3.07	No	No	0	5	5
239	R:R:K128	R:R:V124	3.04	No	No	0	8	4
240	R:R:A213	R:R:E216	3.02	No	Yes	0	1	3
241	R:R:N118	R:R:S54	2.98	No	No	0	4	5
242	R:R:L245	R:R:T264	2.95	No	No	0	8	7
243	R:R:I142	R:R:I230	2.94	Yes	Yes	1	8	9
244	R:R:I143	R:R:I230	2.94	No	Yes	1	5	9
245	R:R:I230	R:R:I234	2.94	Yes	Yes	0	9	8
246	R:R:I140	R:R:M136	2.92	Yes	Yes	0	7	5
247	R:R:I143	R:R:M226	2.92	No	No	1	5	5
248	R:R:I230	R:R:M226	2.92	Yes	No	1	9	5
249	R:R:I166	R:R:K164	2.91	No	No	0	7	3
250	R:R:M326	R:R:M330	2.89	No	No	0	7	6
251	R:R:K307	R:R:M48	2.88	No	No	0	3	2
252	L:L:?1	R:R:G131	2.86	Yes	No	0	0	6
253	R:R:I190	R:R:L194	2.85	No	Yes	0	5	4
254	R:R:I239	R:R:L272	2.85	No	Yes	0	3	7
255	R:R:I273	R:R:L272	2.85	No	Yes	0	4	7
256	R:R:L183	R:R:M136	2.83	No	Yes	0	4	5
257	R:R:K128	R:R:L194	2.82	No	Yes	0	8	4
258	R:R:K214	R:R:L294	2.82	No	No	0	2	1
259	R:R:D151	R:R:I154	2.8	Yes	No	0	8	6
260	R:R:D209	R:R:K302	2.77	No	Yes	0	5	4
261	R:R:H211	R:R:V296	2.77	No	No	0	4	1
262	R:R:L232	R:R:L236	2.77	No	No	0	2	4
263	R:R:R252	R:R:S258	2.64	No	No	0	4	4
264	R:R:R163	R:R:T167	2.59	No	No	0	5	6
265	R:R:Q161	R:R:Q162	2.56	No	No	0	4	5
266	R:R:S249	R:R:Y261	2.54	No	No	0	3	6
267	R:R:I98	R:R:W179	2.35	No	No	0	5	9
268	L:L:?1	R:R:L181	2.32	Yes	No	0	0	4
269	R:R:G184	R:R:G185	2.11	No	No	0	3	4
270	R:R:G197	R:R:G198	2.11	No	No	0	1	1
271	R:R:R158	R:R:Y153	2.06	No	Yes	0	5	7
272	L:L:?1	R:R:G185	1.91	Yes	No	0	0	4
273	R:R:C46	R:R:P47	1.88	No	No	0	6	2
274	R:R:G71	R:R:V70	1.84	No	No	0	8	4
275	R:R:G185	R:R:T188	1.82	No	No	0	4	8
276	R:R:A75	R:R:A97	1.79	No	No	0	8	9
277	R:R:G81	R:R:I82	1.76	No	No	0	4	5
278	R:R:G123	R:R:L122	1.71	No	Yes	0	7	7
279	R:R:A262	R:R:S249	1.71	No	No	0	5	3
280	R:R:C176	R:R:I172	1.64	No	No	0	4	4
281	R:R:E216	R:R:G215	1.64	Yes	No	0	3	3
282	R:R:C278	R:R:I277	1.64	No	No	0	7	5
283	R:R:S249	R:R:S258	1.63	No	No	0	3	4
284	R:R:N257	R:R:P256	1.63	No	No	0	4	3
285	R:R:C176	R:R:M180	1.62	No	No	0	4	4
286	R:R:A165	R:R:K85	1.61	No	No	0	3	6
287	R:R:V63	R:R:V67	1.6	No	No	0	5	6
288	R:R:V174	R:R:V178	1.6	No	No	0	5	7
289	R:R:T55	R:R:V56	1.59	No	No	0	5	5
290	R:R:I66	R:R:V67	1.54	No	No	0	5	6
291	R:R:I222	R:R:V225	1.54	No	No	0	5	5
292	R:R:M203	R:R:S201	1.53	No	No	0	4	4
293	R:R:K254	R:R:S253	1.53	No	No	0	4	3
294	R:R:I172	R:R:T168	1.52	No	No	0	4	4
295	R:R:M203	R:R:T202	1.51	No	No	0	4	4
296	R:R:L53	R:R:V56	1.49	No	No	0	5	5
297	R:R:L57	R:R:V56	1.49	Yes	No	0	5	5
298	R:R:L329	R:R:V325	1.49	No	No	0	6	6
299	R:R:N200	R:R:V124	1.48	No	No	0	5	4
300	R:R:I334	R:R:I337	1.47	Yes	No	0	8	4
301	R:R:N116	R:R:T121	1.46	No	No	0	3	3
302	R:R:I311	R:R:L57	1.43	No	Yes	0	5	5
303	R:R:I73	R:R:L101	1.43	No	No	0	3	7
304	R:R:I235	R:R:L236	1.43	No	No	0	4	4
305	R:R:E216	R:R:T193	1.41	Yes	No	0	3	5
306	R:R:K85	R:R:N87	1.4	No	No	0	6	8
307	R:R:L122	R:R:L126	1.38	Yes	No	0	7	5
308	R:R:L341	R:R:L342	1.38	No	No	0	4	5
309	R:R:D49	R:R:L52	1.36	No	No	0	4	4
310	R:R:E216	R:R:L192	1.33	Yes	No	0	3	4
311	R:R:N116	R:R:Q117	1.32	No	No	0	3	3
312	R:R:A284	R:R:W228	1.3	No	No	0	6	5
313	R:R:S298	R:R:Y300	1.27	No	No	0	5	2
314	R:R:V78	R:R:Y77	1.26	No	No	0	7	4
315	R:R:F328	R:R:I334	1.26	Yes	Yes	0	6	8
316	R:R:F328	R:R:L329	1.22	Yes	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.395	14	1	0
2	R:R:L57	4.14	5	2	5
3	R:R:Y61	5.268	5	0	8
4	R:R:Y92	7.358	5	4	7
5	R:R:D100	6.26	5	0	9
6	R:R:H114	5.77833	6	2	5
7	R:R:W120	4.696	5	5	9
8	R:R:L122	3.3	4	0	7
9	R:R:L133	4.4975	4	1	5
10	R:R:Y135	9.514	5	1	5
11	R:R:M136	4.82	5	1	5
12	R:R:Y139	8.72	4	0	7
13	R:R:I140	4.41	4	0	7
14	R:R:I142	6.0375	4	1	8
15	R:R:D151	5.755	4	0	8
16	R:R:Y153	6.138	5	0	7
17	R:R:F186	5.0075	4	0	7
18	R:R:L194	3.9025	4	0	4
19	R:R:F205	12.705	4	0	4
20	R:R:E216	1.85	4	0	3
21	R:R:F227	14.1225	4	1	8
22	R:R:I230	2.935	4	1	9
23	R:R:I234	6.2125	4	0	8
24	R:R:Y238	6.892	5	0	8
25	R:R:I241	4.055	4	6	8
26	R:R:L272	4.025	4	0	7
27	R:R:F275	7.62	4	0	9
28	R:R:F279	8.874	5	1	8
29	R:R:Y282	8.43	6	1	6
30	R:R:H283	13.28	5	1	8
31	R:R:R286	8.31571	7	1	6
32	R:R:Y289	8.88	6	1	4
33	R:R:K302	6.23	4	0	4
34	R:R:N309	9.145	4	1	5
35	R:R:L313	5.475	4	1	5
36	R:R:P324	4.6625	4	0	9
37	R:R:F328	3.2725	4	0	6
38	R:R:I334	3.645	4	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y289	11.7532	5.89	Yes	Yes	1	0	4
2	R:R:Y207	R:R:Y289	14.2831	7.94	No	Yes	1	3	4
3	R:R:K302	R:R:Y207	13.0956	14.33	Yes	No	0	4	3
4	L:L:?1	R:R:Y135	31.4869	20.28	Yes	Yes	1	0	5
5	R:R:L313	R:R:Y135	30.9006	5.86	Yes	Yes	1	5	5
6	R:R:L313	R:R:Y61	100	3.52	Yes	Yes	0	5	8
7	R:R:L57	R:R:Y61	40.0649	4.69	Yes	Yes	0	5	8
8	R:R:H114	R:R:L57	23.7609	5.14	Yes	Yes	2	5	5
9	R:R:H114	R:R:N118	16.8646	5.1	Yes	No	0	5	4
10	R:R:E50	R:R:N118	12.1146	5.26	No	No	0	4	4
11	L:L:?1	R:R:N309	17.7681	7.66	Yes	Yes	1	0	5
12	R:R:L313	R:R:N309	26.512	5.49	Yes	Yes	1	5	5
13	R:R:R110	R:R:Y61	51.4862	9.26	No	Yes	0	7	8
14	R:R:H114	R:R:R110	23.3036	4.51	Yes	No	0	5	7
15	R:R:L57	R:R:V56	13.5049	1.49	Yes	No	0	5	5
16	R:R:L53	R:R:V56	11.0267	1.49	No	No	0	5	5
17	R:R:E303	R:R:M48	10.739	4.06	No	No	0	1	2
18	R:R:S317	R:R:Y61	11.2664	3.82	No	Yes	0	7	8
19	R:R:F134	R:R:Y135	26.9214	11.35	No	Yes	0	7	5
20	R:R:F134	R:R:L103	25.8998	7.31	No	No	0	7	7
21	R:R:L103	R:R:L107	14.2757	4.15	No	No	0	7	7
22	R:R:F65	R:R:L107	13.0145	3.65	No	No	0	7	7
23	R:R:L103	R:R:S320	21.9612	4.5	No	No	0	7	8
24	R:R:D100	R:R:S320	21.6736	11.78	Yes	No	0	9	8
25	R:R:D100	R:R:N72	21.6256	6.73	Yes	No	0	9	9
26	R:R:N72	R:R:P324	20.475	6.52	No	Yes	0	9	9
27	R:R:F328	R:R:P324	14.6002	4.33	Yes	Yes	0	6	9
28	L:L:?1	R:R:L223	28.994	8.5	Yes	No	1	0	5
29	R:R:L223	R:R:Y139	29.2005	19.93	No	Yes	0	5	7
30	R:R:I142	R:R:Y139	31.4833	3.63	Yes	Yes	0	8	7
31	R:R:I142	R:R:I230	34.2012	2.94	Yes	Yes	1	8	9
32	R:R:I230	R:R:I234	30.3843	2.94	Yes	Yes	0	9	8
33	R:R:I234	R:R:S149	86.0783	10.84	Yes	No	0	8	9
34	R:R:S149	R:R:Y238	67.5173	5.09	No	Yes	0	9	8
35	R:R:R152	R:R:Y238	47.7062	8.23	No	Yes	0	9	8
36	R:R:I148	R:R:R152	26.0179	7.52	No	No	0	9	9
37	R:R:I148	R:R:Y92	16.2782	4.84	No	Yes	0	9	7
38	R:R:S171	R:R:Y92	11.8675	7.63	No	Yes	0	7	7
39	R:R:I91	R:R:S171	10.5731	4.64	No	No	0	6	7
40	R:R:I89	R:R:R152	20.9618	5.01	No	No	0	7	9
41	R:R:I89	R:R:K155	13.1325	5.82	No	No	0	7	8
42	R:R:K155	R:R:N87	11.8343	4.2	No	No	0	8	8
43	L:L:?1	R:R:M136	20.5561	7.1	Yes	Yes	1	0	5
44	R:R:I140	R:R:M136	11.6905	2.92	Yes	Yes	0	7	5
45	R:R:D100	R:R:D323	15.2751	3.99	Yes	No	0	9	9
46	R:R:S316	R:R:Y282	51.3166	5.09	No	Yes	0	7	6
47	R:R:F279	R:R:S316	50.8998	5.28	Yes	No	0	8	7
48	R:R:R286	R:R:Y282	14.8694	12.35	Yes	Yes	1	6	6
49	R:R:F205	R:R:R110	27.8544	28.86	Yes	No	0	4	7
50	R:R:H114	R:R:Y113	24.1887	10.89	Yes	No	0	5	5
51	R:R:F205	R:R:Y113	11.897	8.25	Yes	No	0	4	5
52	R:R:W120	R:R:Y113	31.9627	3.86	Yes	No	0	9	5
53	R:R:C204	R:R:F205	12.9333	9.78	No	Yes	0	9	4
54	R:R:C204	R:R:W120	10.5362	5.22	No	Yes	5	9	9
55	R:R:L122	R:R:W120	32.9363	5.69	Yes	Yes	0	7	9
56	R:R:L122	R:R:T121	18.8634	4.42	Yes	No	0	7	3
57	R:R:N116	R:R:T121	14.1577	1.46	No	No	0	3	3
58	L:L:?1	R:R:T132	29.9344	4.94	Yes	No	0	0	5
59	R:R:F186	R:R:T132	28.3965	6.49	Yes	No	0	7	5
60	R:R:F186	R:R:I190	26.1027	5.02	Yes	No	0	7	5
61	R:R:I190	R:R:L194	22.9311	2.85	No	Yes	0	5	4
62	R:R:K128	R:R:L194	16.4995	2.82	No	Yes	0	8	4
63	R:R:K128	R:R:T193	11.5983	6.01	No	No	0	8	5
64	R:R:H283	R:R:Y282	11.8048	14.16	Yes	Yes	1	8	6
65	R:R:F275	R:R:F279	50.8814	12.86	Yes	Yes	0	9	8
66	R:R:F275	R:R:L145	14.3126	3.65	Yes	No	0	9	8
67	R:R:S149	R:R:S237	25.8814	6.52	No	No	0	9	6
68	R:R:S237	R:R:Y153	24.7787	3.82	No	Yes	0	6	7
69	R:R:N157	R:R:Y153	23.0491	11.63	No	Yes	0	7	7
70	R:R:S268	R:R:Y238	14.5892	6.36	No	Yes	0	7	8
71	R:R:N157	R:R:N244	21.6477	13.62	No	No	0	7	5
72	L:L:?1	R:R:R208	14.567	18.98	Yes	No	0	0	5
73	R:R:H283	R:R:V224	11.0415	4.15	Yes	No	0	8	4
74	R:R:V271	R:R:Y238	10.7095	10.09	No	Yes	0	7	8
75	R:R:I248	R:R:N244	17.4915	5.66	No	No	0	6	5
76	R:R:I248	R:R:Y261	16.0643	3.63	No	No	0	6	6
77	R:R:V305	R:R:Y289	11.3549	3.79	No	Yes	0	4	4
78	R:R:R286	R:R:Y289	10.492	10.29	Yes	Yes	1	6	4
79	R:R:F275	R:R:I234	57.9768	7.54	Yes	Yes	0	9	8
80	R:R:L313	R:R:Y282	44.3981	7.03	Yes	Yes	1	5	6
81	R:R:D323	R:R:L145	13.055	6.79	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T132	4.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y135	20.28	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M136	7.1	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M189	4.73	1	Yes	No	0	4	0	1
L:L:?1	R:R:R208	18.98	1	Yes	No	0	5	0	1
L:L:?1	R:R:F219	7.48	1	Yes	No	0	5	0	1
L:L:?1	R:R:N220	6.13	1	Yes	No	0	4	0	1
L:L:?1	R:R:L223	8.5	1	Yes	No	0	5	0	1
L:L:?1	R:R:R286	4.75	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y289	5.89	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:N309	7.66	1	Yes	Yes	0	5	0	1
R:R:F186	R:R:T132	6.49	0	Yes	No	7	5	2	1
R:R:L133	R:R:M136	4.24	1	Yes	Yes	5	5	2	1
R:R:L133	R:R:N137	4.12	1	Yes	No	5	8	2	2
R:R:F186	R:R:L133	4.87	0	Yes	Yes	7	5	2	2
R:R:F134	R:R:Y135	11.35	0	No	Yes	7	5	2	1
R:R:Y135	R:R:Y282	5.96	1	Yes	Yes	5	6	1	2
R:R:R286	R:R:Y135	4.12	1	Yes	Yes	6	5	1	1
R:R:L313	R:R:Y135	5.86	1	Yes	Yes	5	5	2	1
R:R:M136	R:R:N137	7.01	1	Yes	No	5	8	1	2
R:R:L223	R:R:Y139	19.93	1	No	Yes	5	7	1	2
R:R:F219	R:R:M189	8.71	1	No	No	5	4	1	1
R:R:H206	R:R:R208	7.9	0	No	No	5	5	2	1
R:R:Y207	R:R:Y289	7.94	1	No	Yes	3	4	2	1
R:R:Q293	R:R:Y207	9.02	1	No	No	4	3	2	2
R:R:K210	R:R:R208	4.95	0	No	No	3	5	2	1
R:R:K210	R:R:Q293	13.56	0	No	No	3	4	2	2
R:R:F219	R:R:L223	3.65	1	No	No	5	5	1	1
R:R:N220	R:R:R286	16.87	1	No	Yes	4	6	1	1
R:R:I290	R:R:N220	7.08	1	No	No	5	4	2	1
R:R:R286	R:R:Y282	12.35	1	Yes	Yes	6	6	1	2
R:R:L313	R:R:Y282	7.03	1	Yes	Yes	5	6	2	2
R:R:R286	R:R:Y289	10.29	1	Yes	Yes	6	4	1	1
R:R:I290	R:R:R286	5.01	1	No	Yes	5	6	2	1
R:R:N309	R:R:R286	4.82	1	Yes	Yes	5	6	1	1
R:R:Q293	R:R:Y289	6.76	1	No	Yes	4	4	2	1
R:R:V305	R:R:Y289	3.79	0	No	Yes	4	4	2	1
R:R:N309	R:R:Y289	18.61	1	Yes	Yes	5	4	1	1
R:R:L313	R:R:N309	5.49	1	Yes	Yes	5	5	2	1
R:R:I140	R:R:M136	2.92	0	Yes	Yes	7	5	2	1
L:L:?1	R:R:G131	2.86	1	Yes	No	0	6	0	1
R:R:L183	R:R:M136	2.83	0	No	Yes	4	5	2	1
L:L:?1	R:R:L181	2.32	1	Yes	No	0	4	0	1
R:R:G184	R:R:G185	2.11	0	No	No	3	4	2	1
L:L:?1	R:R:G185	1.91	1	Yes	No	0	4	0	1
R:R:G185	R:R:T188	1.82	0	No	No	4	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XBH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	286
Number of Links	316
Number of Hubs	38
Number of Links mediated by Hubs	145
Number of Communities	8
Number of Nodes involved in Communities	46
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	62466
Length Of Smallest Path	3
Average Path Length	12.8125
Length of Longest Path	27
Minimum Path Strength	1.24
Average Path Strength	6.86381
Maximum Path Strength	25.745
Minimum Path Correlation	0.7
Average Path Correlation	0.939639
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	54.4669
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.2716
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KW3
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KW3
Name	(2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid
Synonyms
Identifier
Formula	C30 H36 N O11 P
Molecular Weight	617.581
SMILES
PubChem	162656636
Formal Charge	0
Total Atoms	79
Total Chiral Atoms	2
Total Bonds	81
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UPC5
Sequence	>8XBH_nogp_Chain_R T C P M D E K L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H R K R N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q N K W T L G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S I Q Q R K A I T T K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G G H N S T M C F H Y R D K H N A K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K R R S K F P N S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S Q L N V S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N I R K I M C Q L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8SAI	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (S12)	-	Gi1/β1/γ2	3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8SAI (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (S12)	-		3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8K4N	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 168719765	-	Gi1/β1/γ2	2.83	2023-10-25	To be published
	8K4N (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 168719765	-		2.83	2023-10-25	To be published
	8WRB	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (UBL)	-	Gi1/β1/γ2	2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8WRB (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (UBL)	-		2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8XBE	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-Lysophosphatidylserine	-	Gi1/β1/γ1	3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBE (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-Lysophosphatidylserine	-		3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBG	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-Lysophosphatidylserine	-	-	3.43	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBH	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 162656636	-	Gi1/β1/γ2	2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBH (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 162656636	-		2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBI	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 162656636	-	-	3.06	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8IYX	A	Orphan	Orphan	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	doi.org/10.1073/pnas.2308435120
	8IZ4	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (TJR)	-	Gi1/β1/γ2	2.94	2024-04-10	To be published
	8IZ4 (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (TJR)	-		2.94	2024-04-10	To be published

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