psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:S1	10.56	Yes	Yes	1	0	0
2	L:L:S1	R:R:Y135	6.36	Yes	Yes	1	0	5
3	L:L:S1	R:R:R286	3.95	Yes	Yes	1	0	6
4	L:L:S1	R:R:N309	4.47	Yes	Yes	1	0	5
5	L:L:?2	R:R:T132	5.18	Yes	No	1	0	5
6	L:L:?2	R:R:Y135	15.67	Yes	Yes	1	0	5
7	L:L:?2	R:R:M189	10.94	Yes	No	0	0	4
8	L:L:?2	R:R:R208	7.69	Yes	Yes	1	0	5
9	L:L:?2	R:R:N220	6.76	Yes	No	1	0	4
10	L:L:?2	R:R:L223	8.76	Yes	No	0	0	5
11	L:L:?2	R:R:M226	4.97	Yes	No	0	0	5
12	R:R:E50	R:R:L53	6.63	No	Yes	0	4	5
13	R:R:E50	R:R:N118	7.89	No	Yes	0	4	4
14	R:R:E50	R:R:H306	6.15	No	Yes	0	4	4
15	R:R:K51	R:R:L52	4.23	No	No	0	4	4
16	R:R:L53	R:R:L57	6.92	Yes	No	0	5	5
17	R:R:E310	R:R:L53	3.98	No	Yes	0	5	5
18	R:R:N118	R:R:S54	5.96	Yes	No	0	4	5
19	R:R:H114	R:R:L57	12.86	Yes	No	0	5	5
20	R:R:H114	R:R:T58	4.11	Yes	No	0	5	5
21	R:R:S60	R:R:V314	4.85	No	No	0	5	5
22	R:R:L107	R:R:Y61	4.69	No	Yes	0	7	8
23	R:R:R110	R:R:Y61	17.49	Yes	Yes	0	7	8
24	R:R:V314	R:R:Y61	7.57	No	Yes	0	5	8
25	R:R:S317	R:R:Y61	5.09	No	Yes	0	7	8
26	R:R:F318	R:R:I64	5.02	No	No	0	5	7
27	R:R:F65	R:R:I104	3.77	Yes	No	0	7	5
28	R:R:F65	R:R:P108	7.22	Yes	No	0	7	9
29	R:R:C321	R:R:V67	6.83	No	No	0	7	6
30	R:R:C321	R:R:G68	3.92	No	No	0	7	8
31	R:R:I73	R:R:L69	4.28	No	No	0	3	6
32	R:R:D100	R:R:N72	5.39	Yes	No	0	9	9
33	R:R:N72	R:R:P324	9.77	No	No	0	9	9
34	R:R:F328	R:R:I74	3.77	No	No	0	6	5
35	R:R:I82	R:R:V78	4.61	Yes	No	0	5	7
36	R:R:F79	R:R:Q90	4.68	Yes	Yes	2	6	7
37	R:R:F79	R:R:L93	4.87	Yes	No	2	6	8
38	R:R:F79	R:R:Y327	7.22	Yes	Yes	2	6	9
39	R:R:L80	R:R:R86	4.86	Yes	No	0	3	7
40	R:R:L80	R:R:L94	4.15	Yes	No	0	3	6
41	R:R:H83	R:R:I82	3.98	No	Yes	0	5	5
42	R:R:I337	R:R:I82	4.42	No	Yes	0	4	5
43	R:R:H83	R:R:Q90	8.65	No	Yes	0	5	7
44	R:R:I91	R:R:R86	3.76	No	No	0	6	7
45	R:R:N87	R:R:Q90	11.88	No	Yes	0	8	7
46	R:R:D151	R:R:S88	8.83	No	No	5	8	6
47	R:R:K155	R:R:S88	4.59	No	No	5	8	6
48	R:R:D151	R:R:I89	8.4	No	No	0	8	7
49	R:R:I89	R:R:R152	6.26	No	No	0	7	9
50	R:R:Q90	R:R:Y327	4.51	Yes	Yes	2	7	9
51	R:R:I91	R:R:S171	7.74	No	No	0	6	7
52	R:R:F147	R:R:Y92	4.13	No	Yes	6	5	7
53	R:R:I148	R:R:Y92	4.84	No	Yes	0	9	7
54	R:R:S171	R:R:Y92	12.72	No	Yes	0	7	7
55	R:R:V174	R:R:Y92	6.31	No	Yes	6	5	7
56	R:R:L93	R:R:Y327	4.69	No	Yes	2	8	9
57	R:R:C175	R:R:N95	6.3	No	No	0	6	9
58	R:R:L144	R:R:V96	4.47	No	No	0	7	9
59	R:R:D323	R:R:V96	4.38	Yes	No	0	9	9
60	R:R:D100	R:R:S141	5.89	Yes	No	0	9	9
61	R:R:D100	R:R:S320	8.83	Yes	No	0	9	8
62	R:R:D100	R:R:D323	6.65	Yes	Yes	0	9	9
63	R:R:L102	R:R:N137	8.24	No	No	0	7	8
64	R:R:F134	R:R:L103	10.96	Yes	No	0	7	7
65	R:R:L103	R:R:S320	7.51	No	No	0	7	8
66	R:R:C106	R:R:L133	4.76	No	No	0	6	5
67	R:R:F109	R:R:V130	15.73	No	No	0	6	5
68	R:R:H114	R:R:R110	7.9	Yes	Yes	0	5	7
69	R:R:F205	R:R:R110	18.17	No	Yes	0	4	7
70	R:R:E310	R:R:R110	8.14	No	Yes	0	5	7
71	R:R:H114	R:R:Y113	7.62	Yes	No	3	5	5
72	R:R:N118	R:R:Y113	16.28	Yes	No	3	4	5
73	R:R:W120	R:R:Y113	7.72	Yes	No	3	9	5
74	R:R:H114	R:R:N118	5.1	Yes	Yes	3	5	4
75	R:R:L122	R:R:W120	10.25	No	Yes	0	7	9
76	R:R:C127	R:R:W120	5.22	No	Yes	3	9	9
77	R:R:C204	R:R:W120	7.84	No	Yes	3	9	9
78	R:R:L122	R:R:L126	6.92	No	No	0	7	5
79	R:R:I125	R:R:L194	4.28	No	No	0	1	4
80	R:R:C127	R:R:C204	7.28	No	No	3	9	9
81	R:R:K128	R:R:T193	6.01	No	No	1	8	5
82	R:R:H199	R:R:K128	11.79	Yes	No	1	3	8
83	R:R:K128	R:R:R208	7.43	No	Yes	1	8	5
84	R:R:F205	R:R:G131	4.52	No	No	0	4	6
85	R:R:F186	R:R:T132	5.19	Yes	No	1	7	5
86	R:R:I190	R:R:T132	4.56	Yes	No	1	5	5
87	R:R:F134	R:R:L313	6.09	Yes	No	0	7	5
88	R:R:F134	R:R:S317	6.61	Yes	No	0	7	7
89	R:R:Y135	R:R:Y282	5.96	Yes	Yes	1	5	6
90	R:R:L313	R:R:Y135	5.86	No	Yes	1	5	5
91	R:R:F186	R:R:M136	4.98	Yes	No	0	7	5
92	R:R:M138	R:R:Y139	4.79	No	No	0	7	7
93	R:R:M138	R:R:S316	6.13	No	No	0	7	7
94	R:R:L223	R:R:Y139	7.03	No	No	0	5	7
95	R:R:H283	R:R:Y139	7.62	No	No	0	8	7
96	R:R:I140	R:R:W179	8.22	No	No	0	7	9
97	R:R:F227	R:R:I142	7.54	Yes	No	0	8	8
98	R:R:F279	R:R:I142	15.07	Yes	No	0	8	8
99	R:R:I143	R:R:V178	4.61	No	No	0	5	7
100	R:R:I143	R:R:M226	5.83	No	No	0	5	5
101	R:R:D323	R:R:L145	5.43	Yes	No	0	9	8
102	R:R:F147	R:R:V174	7.87	No	No	6	5	5
103	R:R:I148	R:R:R152	7.52	No	No	0	9	9
104	R:R:I234	R:R:S149	7.74	Yes	No	0	8	9
105	R:R:S149	R:R:S237	4.89	No	No	0	9	6
106	R:R:S149	R:R:Y238	11.45	No	Yes	0	9	8
107	R:R:D151	R:R:K155	6.91	No	No	5	8	8
108	R:R:R152	R:R:Y238	8.23	No	Yes	0	9	8
109	R:R:N157	R:R:Y153	8.14	No	Yes	0	7	7
110	R:R:S237	R:R:Y153	3.82	No	Yes	0	6	7
111	R:R:K240	R:R:Y153	9.55	No	Yes	0	4	7
112	R:R:I156	R:R:I241	4.42	No	No	0	8	8
113	R:R:N157	R:R:N244	13.62	No	No	0	7	5
114	R:R:K169	R:R:Y173	8.36	No	No	0	4	2
115	R:R:F186	R:R:I190	6.28	Yes	Yes	1	7	5
116	R:R:E216	R:R:M189	5.41	Yes	No	0	3	4
117	R:R:F219	R:R:M189	8.71	No	No	0	5	4
118	R:R:H199	R:R:T193	6.85	Yes	No	1	3	5
119	R:R:E216	R:R:T193	8.47	Yes	No	1	3	5
120	R:R:K196	R:R:N212	4.2	No	No	0	3	2
121	R:R:H206	R:R:M203	18.38	No	No	0	5	4
122	R:R:C204	R:R:F205	11.17	No	No	0	9	4
123	R:R:H206	R:R:R208	7.9	No	Yes	0	5	5
124	R:R:Y207	R:R:Y289	9.93	Yes	Yes	1	3	4
125	R:R:S292	R:R:Y207	5.09	No	Yes	0	3	3
126	R:R:Q293	R:R:Y207	4.51	No	Yes	1	4	3
127	R:R:K302	R:R:Y207	4.78	No	Yes	0	4	3
128	R:R:H306	R:R:Y207	4.36	Yes	Yes	0	4	3
129	R:R:K210	R:R:R208	4.95	Yes	Yes	1	3	5
130	R:R:E216	R:R:R208	5.82	Yes	Yes	1	3	5
131	R:R:D209	R:R:H211	7.56	No	No	0	5	4
132	R:R:D209	R:R:K302	4.15	No	No	0	5	4
133	R:R:E216	R:R:K210	12.15	Yes	Yes	1	3	3
134	R:R:K210	R:R:Q293	13.56	Yes	No	1	3	4
135	R:R:F219	R:R:L223	6.09	No	No	0	5	5
136	R:R:N220	R:R:R286	12.05	No	Yes	1	4	6
137	R:R:I290	R:R:N220	4.25	No	No	1	5	4
138	R:R:F221	R:R:V225	5.24	No	No	0	4	5
139	R:R:F221	R:R:F287	6.43	No	No	0	4	6
140	R:R:R286	R:R:V224	3.92	Yes	No	0	6	4
141	R:R:F287	R:R:V224	7.87	No	No	0	6	4
142	R:R:F227	R:R:W228	7.02	Yes	Yes	4	8	5
143	R:R:F227	R:R:F231	5.36	Yes	Yes	4	8	7
144	R:R:F227	R:R:H283	36.2	Yes	No	0	8	8
145	R:R:F231	R:R:W228	4.01	Yes	Yes	4	7	5
146	R:R:F287	R:R:W228	4.01	No	Yes	0	6	5
147	R:R:F231	R:R:I235	7.54	Yes	No	0	7	4
148	R:R:F231	R:R:F275	6.43	Yes	No	0	7	9
149	R:R:F231	R:R:T276	7.78	Yes	No	4	7	5
150	R:R:F231	R:R:V280	7.87	Yes	No	4	7	5
151	R:R:F275	R:R:I234	8.79	No	Yes	0	9	8
152	R:R:I235	R:R:L272	5.71	No	No	0	4	7
153	R:R:V271	R:R:Y238	8.83	No	Yes	0	7	8
154	R:R:L272	R:R:Y238	4.69	No	Yes	0	7	8
155	R:R:I241	R:R:S268	4.64	No	No	0	8	7
156	R:R:F269	R:R:G242	6.02	No	No	0	4	4
157	R:R:R247	R:R:R251	4.26	No	No	0	5	4
158	R:R:I248	R:R:Y261	7.25	No	Yes	0	6	6
159	R:R:F255	R:R:R252	24.59	No	Yes	0	3	4
160	R:R:R252	R:R:Y261	10.29	Yes	Yes	0	4	6
161	R:R:F255	R:R:P256	5.78	No	No	0	3	3
162	R:R:K260	R:R:Y261	4.78	No	Yes	0	5	6
163	R:R:R266	R:R:T263	3.88	No	No	0	6	7
164	R:R:N267	R:R:R266	4.82	No	No	0	7	6
165	R:R:I270	R:R:R266	3.76	No	No	0	5	6
166	R:R:M330	R:R:N267	15.43	No	No	0	6	7
167	R:R:M326	R:R:V271	10.65	No	No	0	7	7
168	R:R:I274	R:R:L322	4.28	No	No	0	6	6
169	R:R:F275	R:R:F279	9.65	No	Yes	0	9	8
170	R:R:T276	R:R:V280	4.76	No	No	4	5	5
171	R:R:C278	R:R:N319	4.72	No	No	0	7	9
172	R:R:F279	R:R:S316	6.61	Yes	No	0	8	7
173	R:R:F279	R:R:N319	9.67	Yes	No	0	8	9
174	R:R:H283	R:R:Y282	11.98	No	Yes	0	8	6
175	R:R:R286	R:R:Y282	12.35	Yes	Yes	1	6	6
176	R:R:N309	R:R:Y282	6.98	Yes	Yes	1	5	6
177	R:R:L313	R:R:Y282	7.03	No	Yes	1	5	6
178	R:R:F285	R:R:I288	11.3	Yes	No	0	5	5
179	R:R:F285	R:R:V305	6.55	Yes	Yes	0	5	4
180	R:R:F285	R:R:T308	15.56	Yes	No	7	5	5
181	R:R:F285	R:R:M312	4.98	Yes	No	7	5	6
182	R:R:R286	R:R:Y289	17.49	Yes	Yes	1	6	4
183	R:R:I290	R:R:R286	3.76	No	Yes	1	5	6
184	R:R:N309	R:R:R286	7.23	Yes	Yes	1	5	6
185	R:R:Q293	R:R:Y289	10.15	No	Yes	1	4	4
186	R:R:V305	R:R:Y289	5.05	Yes	Yes	0	4	4
187	R:R:N309	R:R:Y289	13.96	Yes	Yes	1	5	4
188	R:R:S292	R:R:V305	4.85	No	Yes	0	3	4
189	R:R:K302	R:R:S297	7.65	No	No	0	4	2
190	R:R:I304	R:R:Y300	9.67	No	No	0	3	2
191	R:R:V305	R:R:W301	8.58	Yes	No	0	4	1
192	R:R:E303	R:R:H306	6.15	No	Yes	0	1	4
193	R:R:E310	R:R:H306	13.54	No	Yes	0	5	4
194	R:R:M312	R:R:T308	4.52	No	No	7	6	5
195	R:R:F318	R:R:L322	8.53	No	No	0	5	6
196	R:R:D323	R:R:N319	13.46	Yes	No	0	9	9
197	R:R:M326	R:R:M330	5.78	No	No	0	7	6
198	R:R:S331	R:R:Y327	10.17	No	Yes	2	8	9
199	R:R:I334	R:R:Y327	4.84	No	Yes	2	8	9
200	R:R:I334	R:R:S331	4.64	No	No	2	8	8
201	R:R:K336	R:R:S332	6.12	No	No	0	5	5
202	R:R:C339	R:R:M338	4.86	No	No	0	4	5
203	R:R:A75	R:R:P324	3.74	No	No	0	8	9
204	R:R:F65	R:R:L69	3.65	Yes	No	0	7	6
205	R:R:F65	R:R:L107	3.65	Yes	No	0	7	7
206	R:R:F105	R:R:L69	3.65	No	No	0	5	6
207	R:R:F79	R:R:L94	3.65	Yes	No	0	6	6
208	R:R:F105	R:R:L101	3.65	No	No	0	5	7
209	R:R:G185	R:R:T188	3.64	No	No	0	4	8
210	R:R:I82	R:R:Y77	3.63	Yes	No	0	5	4
211	R:R:I241	R:R:Y153	3.63	No	Yes	0	8	7
212	R:R:G68	R:R:I104	3.53	No	No	0	8	5
213	R:R:G146	R:R:I234	3.53	No	Yes	0	7	8
214	R:R:P281	R:R:V280	3.53	No	No	0	9	5
215	R:R:G215	R:R:K214	3.49	No	No	0	3	2
216	R:R:N95	R:R:W179	3.39	No	No	0	9	9
217	L:L:?2	R:R:A182	3.33	Yes	No	0	0	7
218	R:R:L315	R:R:P281	3.28	No	No	0	7	9
219	R:R:C321	R:R:I64	3.27	No	No	0	7	7
220	R:R:A99	R:R:I140	3.25	No	No	0	8	7
221	R:R:A182	R:R:I140	3.25	No	No	0	7	7
222	R:R:S201	R:R:V124	3.23	No	No	0	4	4
223	R:R:A213	R:R:K210	3.21	No	Yes	0	1	3
224	R:R:S88	R:R:T167	3.2	No	No	0	6	6
225	R:R:A265	R:R:L245	3.15	No	No	0	5	8
226	R:R:A265	R:R:L246	3.15	No	No	0	5	3
227	R:R:I111	R:R:S62	3.1	No	No	0	7	6
228	R:R:F109	R:R:W120	3.01	No	Yes	0	6	9
229	R:R:K119	R:R:T121	3	No	No	0	4	3
230	R:R:K260	R:R:T264	3	No	No	0	5	7
231	R:R:L329	R:R:V325	2.98	No	No	0	6	6
232	R:R:N333	R:R:S332	2.98	No	No	0	6	5
233	R:R:L192	R:R:T188	2.95	No	No	0	4	8
234	R:R:L245	R:R:T264	2.95	No	No	0	8	7
235	R:R:I111	R:R:I115	2.94	No	No	0	7	4
236	R:R:I142	R:R:I230	2.94	No	No	0	8	9
237	R:R:I143	R:R:I230	2.94	No	No	0	5	9
238	R:R:I230	R:R:I234	2.94	No	Yes	0	9	8
239	R:R:I273	R:R:I277	2.94	No	No	0	4	5
240	R:R:F328	R:R:P324	2.89	No	No	0	6	9
241	R:R:Q170	R:R:V174	2.87	No	No	0	3	5
242	R:R:I311	R:R:L53	2.85	No	Yes	0	5	5
243	R:R:I156	R:R:L245	2.85	No	No	0	8	8
244	R:R:I177	R:R:L181	2.85	No	No	0	3	4
245	R:R:I190	R:R:L194	2.85	Yes	No	0	5	4
246	R:R:I239	R:R:L272	2.85	No	No	0	3	7
247	R:R:L183	R:R:M136	2.83	No	No	0	4	5
248	R:R:K307	R:R:L53	2.82	No	Yes	0	3	5
249	R:R:G123	R:R:W120	2.81	No	Yes	0	7	9
250	R:R:C106	R:R:F134	2.79	No	Yes	0	6	7
251	R:R:L76	R:R:L80	2.77	No	Yes	0	7	3
252	R:R:H199	R:R:V124	2.77	Yes	No	0	3	4
253	R:R:L150	R:R:L233	2.77	No	No	0	5	7
254	R:R:L103	R:R:N137	2.75	No	No	0	7	8
255	R:R:L133	R:R:N137	2.75	No	No	0	5	8
256	R:R:R252	R:R:S258	2.64	Yes	No	0	4	4
257	R:R:S249	R:R:Y261	2.54	No	Yes	0	3	6
258	R:R:F186	R:R:L187	2.44	Yes	No	0	7	4
259	R:R:I111	R:R:Y61	2.42	No	Yes	0	7	8
260	R:R:I98	R:R:W179	2.35	No	No	0	5	9
261	R:R:G184	R:R:G185	2.11	No	No	0	3	4
262	R:R:G197	R:R:G198	2.11	No	No	0	1	1
263	R:R:A265	R:R:G242	1.95	No	No	0	5	4
264	R:R:A262	R:R:G259	1.95	No	No	0	5	4
265	R:R:G71	R:R:V70	1.84	No	No	0	8	4
266	R:R:G197	R:R:K196	1.74	No	No	0	1	3
267	R:R:G81	R:R:L80	1.71	No	Yes	0	4	3
268	R:R:A262	R:R:S249	1.71	No	No	0	5	3
269	R:R:C176	R:R:I172	1.64	No	No	0	4	4
270	R:R:S60	R:R:V56	1.62	No	No	0	5	5
271	R:R:A217	R:R:K210	1.61	No	Yes	0	4	3
272	R:R:V63	R:R:V67	1.6	No	No	0	5	6
273	R:R:G197	R:R:H199	1.59	No	Yes	0	1	3
274	R:R:A97	R:R:L76	1.58	No	No	0	9	7
275	R:R:A217	R:R:L294	1.58	No	No	0	4	1
276	R:R:I74	R:R:V70	1.54	No	No	0	5	4
277	R:R:I125	R:R:V129	1.54	No	No	0	1	5
278	R:R:I190	R:R:V129	1.54	Yes	No	0	5	5
279	R:R:I304	R:R:T308	1.52	No	No	0	3	5
280	R:R:F219	R:R:G185	1.51	No	No	0	5	4
281	R:R:M203	R:R:T202	1.51	No	No	0	4	4
282	R:R:I172	R:R:I91	1.47	No	No	0	4	6
283	R:R:I218	R:R:I222	1.47	No	No	0	5	5
284	R:R:N200	R:R:T202	1.46	No	No	0	5	4
285	R:R:I218	R:R:K214	1.45	No	No	0	5	2
286	R:R:I115	R:R:N116	1.42	No	No	0	4	3
287	R:R:K119	R:R:N116	1.4	No	No	0	4	3
288	R:R:L294	R:R:N295	1.37	No	No	0	1	1
289	R:R:A284	R:R:W228	1.3	No	Yes	0	6	5
290	R:R:S298	R:R:Y300	1.27	No	No	0	5	2
291	R:R:F65	R:R:I66	1.26	Yes	No	0	7	5
292	R:R:I154	R:R:Y153	1.21	No	Yes	0	6	7
293	R:R:N244	R:R:R247	1.21	No	No	0	5	5
294	R:R:N257	R:R:R252	1.21	No	Yes	0	4	4
295	L:L:?2	R:R:I222	1	Yes	No	0	0	5
296	L:L:?2	R:R:L229	0.97	Yes	No	0	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:S1	6.335	4	1	0
2	L:L:?2	6.89364	11	1	0
3	R:R:L53	4.64	5	0	5
4	R:R:Y61	7.452	5	0	8
5	R:R:F65	3.91	5	0	7
6	R:R:F79	5.105	4	2	6
7	R:R:L80	3.3725	4	0	3
8	R:R:I82	4.16	4	0	5
9	R:R:Q90	7.43	4	2	7
10	R:R:Y92	7	4	6	7
11	R:R:D100	6.69	4	0	9
12	R:R:R110	12.925	4	0	7
13	R:R:H114	7.518	5	3	5
14	R:R:N118	8.8075	4	3	4
15	R:R:W120	6.14167	6	3	9
16	R:R:F134	6.6125	4	0	7
17	R:R:Y135	8.4625	4	1	5
18	R:R:Y153	5.27	5	0	7
19	R:R:F186	4.7225	4	1	7
20	R:R:I190	3.8075	4	1	5
21	R:R:H199	5.75	4	1	3
22	R:R:Y207	5.734	5	1	3
23	R:R:R208	6.758	5	1	5
24	R:R:K210	7.096	5	1	3
25	R:R:E216	7.9625	4	1	3
26	R:R:F227	14.03	4	4	8
27	R:R:W228	4.085	4	4	5
28	R:R:F231	6.49833	6	4	7
29	R:R:I234	5.75	4	0	8
30	R:R:Y238	8.3	4	0	8
31	R:R:R252	9.6825	4	0	4
32	R:R:Y261	6.215	4	0	6
33	R:R:F279	10.25	4	0	8
34	R:R:Y282	8.86	5	1	6
35	R:R:F285	9.5975	4	7	5
36	R:R:R286	8.67857	7	1	6
37	R:R:Y289	11.316	5	1	4
38	R:R:V305	6.2575	4	0	4
39	R:R:H306	7.55	4	0	4
40	R:R:N309	8.16	4	1	5
41	R:R:D323	7.48	4	0	9
42	R:R:Y327	6.286	5	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:N220	14.1838	6.76	Yes	No	1	0	4
2	R:R:N220	R:R:R286	13.3425	12.05	No	Yes	1	4	6
3	L:L:?2	L:L:S1	24.4588	10.56	Yes	Yes	1	0	0
4	L:L:S1	R:R:R286	13.1865	3.95	Yes	Yes	1	0	6
5	R:R:R286	R:R:Y289	63.2905	17.49	Yes	Yes	1	6	4
6	R:R:Y207	R:R:Y289	68.773	9.93	Yes	Yes	1	3	4
7	R:R:H306	R:R:Y207	68.6549	4.36	Yes	Yes	0	4	3
8	R:R:E50	R:R:H306	42.3811	6.15	No	Yes	0	4	4
9	R:R:E50	R:R:L53	12.0711	6.63	No	Yes	0	4	5
10	L:L:S1	R:R:N309	11.6504	4.47	Yes	Yes	1	0	5
11	R:R:N309	R:R:Y289	35.7784	13.96	Yes	Yes	1	5	4
12	L:L:?2	R:R:R208	27.4648	7.69	Yes	Yes	1	0	5
13	R:R:K210	R:R:R208	14.9116	4.95	Yes	Yes	1	3	5
14	R:R:K210	R:R:Q293	16.9676	13.56	Yes	No	1	3	4
15	R:R:Q293	R:R:Y207	14.0231	4.51	No	Yes	1	4	3
16	R:R:E50	R:R:N118	28.4148	7.89	No	Yes	0	4	4
17	R:R:E310	R:R:H306	21.3489	13.54	No	Yes	0	5	4
18	R:R:E310	R:R:L53	12.5579	3.98	No	Yes	0	5	5
19	L:L:?2	R:R:Y135	27.6397	15.67	Yes	Yes	1	0	5
20	R:R:L313	R:R:Y135	24.7141	5.86	No	Yes	1	5	5
21	R:R:F134	R:R:L313	60.3838	6.09	Yes	No	0	7	5
22	R:R:F134	R:R:S317	54.0363	6.61	Yes	No	0	7	7
23	R:R:S317	R:R:Y61	53.0154	5.09	No	Yes	0	7	8
24	R:R:R110	R:R:Y61	29.913	17.49	Yes	Yes	0	7	8
25	R:R:H114	R:R:R110	12.7422	7.9	Yes	Yes	0	5	7
26	R:R:L107	R:R:Y61	25.8673	4.69	No	Yes	0	7	8
27	R:R:F65	R:R:L107	24.421	3.65	Yes	No	0	7	7
28	R:R:F65	R:R:I104	14.0325	3.77	Yes	No	0	7	5
29	R:R:G68	R:R:I104	12.5106	3.53	No	No	0	8	5
30	R:R:C321	R:R:G68	10.9793	3.92	No	No	0	7	8
31	R:R:F134	R:R:L103	14.8171	10.96	Yes	No	0	7	7
32	R:R:L103	R:R:S320	13.1203	7.51	No	No	0	7	8
33	R:R:D100	R:R:S320	12.7753	8.83	Yes	No	0	9	8
34	L:L:?2	R:R:M226	56.3617	4.97	Yes	No	0	0	5
35	R:R:I143	R:R:M226	55.7047	5.83	No	No	0	5	5
36	R:R:I143	R:R:I230	54.3671	2.94	No	No	0	5	9
37	R:R:I230	R:R:I234	70.9472	2.94	No	Yes	0	9	8
38	R:R:I234	R:R:S149	100	7.74	Yes	No	0	8	9
39	R:R:S149	R:R:Y238	23.9909	11.45	No	Yes	0	9	8
40	R:R:R152	R:R:Y238	50.6948	8.23	No	Yes	0	9	8
41	R:R:I148	R:R:R152	42.2299	7.52	No	No	0	9	9
42	R:R:I148	R:R:Y92	40.7505	4.84	No	Yes	0	9	7
43	R:R:S171	R:R:Y92	34.9513	12.72	No	Yes	0	7	7
44	R:R:I91	R:R:S171	33.4247	7.74	No	No	0	6	7
45	R:R:I91	R:R:R86	28.7882	3.76	No	No	0	6	7
46	R:R:L80	R:R:R86	27.219	4.86	Yes	No	0	3	7
47	R:R:L80	R:R:L94	21.0748	4.15	Yes	No	0	3	6
48	R:R:F79	R:R:L94	19.4678	3.65	Yes	No	0	6	6
49	R:R:F79	R:R:Q90	11.5559	4.68	Yes	Yes	2	6	7
50	L:L:?2	R:R:A182	13.3614	3.33	Yes	No	0	0	7
51	R:R:A182	R:R:I140	11.4803	3.25	No	No	0	7	7
52	R:R:D100	R:R:D323	10.3176	6.65	Yes	Yes	0	9	9
53	L:L:?2	R:R:L223	11.2345	8.76	Yes	No	0	0	5
54	R:R:F279	R:R:N319	13.6733	9.67	Yes	No	0	8	9
55	R:R:D323	R:R:N319	11.9057	13.46	Yes	No	0	9	9
56	R:R:I142	R:R:I230	22.7952	2.94	No	No	0	8	9
57	R:R:N118	R:R:Y113	21.4907	16.28	Yes	No	3	4	5
58	R:R:W120	R:R:Y113	25.3994	7.72	Yes	No	3	9	5
59	R:R:F109	R:R:W120	10.6106	3.01	No	Yes	0	6	9
60	R:R:F205	R:R:R110	12.4965	18.17	No	Yes	0	4	7
61	R:R:L122	R:R:W120	10.6106	10.25	No	Yes	0	7	9
62	L:L:?2	R:R:T132	18.9479	5.18	Yes	No	1	0	5
63	R:R:K128	R:R:R208	11.2062	7.43	No	Yes	1	8	5
64	R:R:H283	R:R:Y282	80.3809	11.98	No	Yes	0	8	6
65	R:R:F227	R:R:H283	82.7961	36.2	Yes	No	0	8	8
66	R:R:S149	R:R:S237	84.7764	4.89	No	No	0	9	6
67	R:R:S237	R:R:Y153	81.7988	3.82	No	Yes	0	6	7
68	R:R:N157	R:R:Y153	12.4586	8.14	No	Yes	0	7	7
69	R:R:I241	R:R:Y153	61.1022	3.63	No	Yes	0	8	7
70	R:R:I156	R:R:I241	55.3455	4.42	No	No	0	8	8
71	R:R:V305	R:R:Y289	32.5976	5.05	Yes	Yes	0	4	4
72	R:R:K302	R:R:Y207	13.5363	4.78	No	Yes	0	4	3
73	R:R:R286	R:R:V224	20.6872	3.92	Yes	No	0	6	4
74	R:R:F287	R:R:V224	20.12	7.87	No	No	0	6	4
75	R:R:F287	R:R:W228	18.9385	4.01	No	Yes	0	6	5
76	R:R:F227	R:R:F231	58.0301	5.36	Yes	Yes	4	8	7
77	R:R:F231	R:R:I235	42.7592	7.54	Yes	No	0	7	4
78	R:R:F275	R:R:I234	34.871	8.79	No	Yes	0	9	8
79	R:R:I235	R:R:L272	41.4453	5.71	No	No	0	4	7
80	R:R:L272	R:R:Y238	39.3846	4.69	No	Yes	0	7	8
81	R:R:V271	R:R:Y238	11.6457	8.83	No	Yes	0	7	8
82	R:R:I156	R:R:L245	52.2592	2.85	No	No	0	8	8
83	R:R:A265	R:R:L245	12.4397	3.15	No	No	0	5	8
84	R:R:L245	R:R:T264	37.5886	2.95	No	No	0	8	7
85	R:R:K260	R:R:T264	34.8852	3	No	No	0	5	7
86	R:R:K260	R:R:Y261	31.7469	4.78	No	Yes	0	5	6
87	R:R:R252	R:R:Y261	15.9041	10.29	Yes	Yes	0	4	6
88	R:R:F285	R:R:V305	25.3946	6.55	Yes	Yes	0	5	4
89	R:R:F285	R:R:T308	14.5713	15.56	Yes	No	7	5	5
90	R:R:I304	R:R:T308	10.9557	1.52	No	No	0	3	5
91	R:R:F219	R:R:G185	10.4736	1.51	No	No	0	5	4
92	R:R:R286	R:R:Y282	26.7936	12.35	Yes	Yes	1	6	6
93	R:R:N309	R:R:Y282	25.1205	6.98	Yes	Yes	1	5	6
94	R:R:F227	R:R:I142	23.5561	7.54	Yes	No	0	8	8
95	R:R:F231	R:R:W228	17.9837	4.01	Yes	Yes	4	7	5
96	R:R:F231	R:R:F275	28.6795	6.43	Yes	No	0	7	9
97	R:R:L313	R:R:Y282	36.5157	7.03	No	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S1	R:R:Y135	6.36	1	Yes	Yes	0	5	0	1
L:L:S1	R:R:R286	3.95	1	Yes	Yes	0	6	0	1
L:L:S1	R:R:N309	4.47	1	Yes	Yes	0	5	0	1
L:L:?2	R:R:T132	5.18	1	Yes	No	0	5	0	1
L:L:?2	R:R:Y135	15.67	1	Yes	Yes	0	5	0	1
L:L:?2	R:R:M189	10.94	1	Yes	No	0	4	0	1
L:L:?2	R:R:R208	7.69	1	Yes	Yes	0	5	0	1
L:L:?2	R:R:N220	6.76	1	Yes	No	0	4	0	1
L:L:?2	R:R:L223	8.76	1	Yes	No	0	5	0	1
L:L:?2	R:R:M226	4.97	1	Yes	No	0	5	0	1
R:R:K128	R:R:R208	7.43	1	No	Yes	8	5	2	1
R:R:F186	R:R:T132	5.19	1	Yes	No	7	5	2	1
R:R:I190	R:R:T132	4.56	1	Yes	No	5	5	2	1
R:R:Y135	R:R:Y282	5.96	1	Yes	Yes	5	6	1	2
R:R:L313	R:R:Y135	5.86	1	No	Yes	5	5	2	1
R:R:L223	R:R:Y139	7.03	0	No	No	5	7	1	2
R:R:I143	R:R:M226	5.83	0	No	No	5	5	2	1
R:R:F186	R:R:I190	6.28	1	Yes	Yes	7	5	2	2
R:R:E216	R:R:M189	5.41	1	Yes	No	3	4	2	1
R:R:F219	R:R:M189	8.71	0	No	No	5	4	2	1
R:R:H206	R:R:R208	7.9	0	No	Yes	5	5	2	1
R:R:K210	R:R:R208	4.95	1	Yes	Yes	3	5	2	1
R:R:E216	R:R:R208	5.82	1	Yes	Yes	3	5	2	1
R:R:E216	R:R:K210	12.15	1	Yes	Yes	3	3	2	2
R:R:F219	R:R:L223	6.09	0	No	No	5	5	2	1
R:R:N220	R:R:R286	12.05	1	No	Yes	4	6	1	1
R:R:I290	R:R:N220	4.25	1	No	No	5	4	2	1
R:R:R286	R:R:V224	3.92	1	Yes	No	6	4	1	2
R:R:R286	R:R:Y282	12.35	1	Yes	Yes	6	6	1	2
R:R:N309	R:R:Y282	6.98	1	Yes	Yes	5	6	1	2
R:R:L313	R:R:Y282	7.03	1	No	Yes	5	6	2	2
R:R:R286	R:R:Y289	17.49	1	Yes	Yes	6	4	1	2
R:R:I290	R:R:R286	3.76	1	No	Yes	5	6	2	1
R:R:N309	R:R:R286	7.23	1	Yes	Yes	5	6	1	1
R:R:N309	R:R:Y289	13.96	1	Yes	Yes	5	4	1	2
L:L:?2	R:R:A182	3.33	1	Yes	No	0	7	0	1
R:R:A182	R:R:I140	3.25	0	No	No	7	7	1	2
R:R:I218	R:R:I222	1.47	0	No	No	5	5	2	1
L:L:?2	R:R:I222	1	1	Yes	No	0	5	0	1
L:L:?2	R:R:L229	0.97	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WRB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.76
Number of Linked Nodes	263
Number of Links	296
Number of Hubs	42
Number of Links mediated by Hubs	162
Number of Communities	7
Number of Nodes involved in Communities	47
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	58401
Length Of Smallest Path	3
Average Path Length	14.2752
Length of Longest Path	33
Minimum Path Strength	1.14667
Average Path Strength	7.45513
Maximum Path Strength	24.09
Minimum Path Correlation	0.7
Average Path Correlation	0.919189
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	41.7428
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.7865
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UBL
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	UBL
Name	[(2R)-2-oxidanyl-3-phosphonooxy-propyl] (Z)-octadec-9-enoate
Synonyms
Identifier
Formula	C21 H41 O7 P
Molecular Weight	436.52
SMILES
PubChem	5311263
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	1
Total Bonds	69
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UPC5
Sequence	>8WRB_nogp_Chain_R E K L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H R K R N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q N K W T L G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N T T K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G G H N S T M C F H Y R D K H N A K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K R R S K F P N S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S Q L N V S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N I R K I M C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XBG	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.43	2024-05-15	10.1038/s41467-024-45046-z
	8XBE	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ1	3.4	2024-05-15	10.1038/s41467-024-45046-z
	8XBE (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		3.4	2024-05-15	10.1038/s41467-024-45046-z
	8IZ4	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.94	2024-04-10	To be published
	8IZ4 (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.94	2024-04-10	To be published
	8IYX	A	Orphan	Orphan	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	10.1073/pnas.2308435120
	8XBI	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.06	2023-12-27	To be published
	8XBH	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ2	2.83	2023-12-27	To be published
	8XBH (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		2.83	2023-12-27	To be published
	8WRB	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.91	2023-11-08	10.1371/journal.pbio.3002387
	8WRB (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.91	2023-11-08	10.1371/journal.pbio.3002387
	8K4N	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-	Gi1/β1/γ2	2.83	2023-10-25	To be published
	8K4N (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-		2.83	2023-10-25	To be published
	8SAI	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-	Gi1/β1/γ2	3.27	2023-10-04	10.1073/pnas.2308435120
	8SAI (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-		3.27	2023-10-04	10.1073/pnas.2308435120

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