psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C299	R:R:M48	4.86	No	No	0	7	2
2	R:R:E50	R:R:H206	8.62	No	No	0	4	5
3	R:R:E303	R:R:E50	6.34	No	No	0	1	4
4	R:R:E50	R:R:H306	4.92	No	No	0	4	4
5	R:R:K51	R:R:L52	4.23	No	No	0	4	4
6	R:R:K307	R:R:L53	5.64	No	No	0	3	5
7	R:R:T59	R:R:V56	3.17	No	No	0	5	5
8	R:R:H114	R:R:L57	3.86	No	Yes	0	5	5
9	R:R:E310	R:R:L57	6.63	No	Yes	0	5	5
10	R:R:I64	R:R:S60	3.1	Yes	No	0	7	5
11	R:R:S60	R:R:V314	3.23	No	No	0	5	5
12	R:R:L107	R:R:Y61	4.69	No	Yes	0	7	8
13	R:R:R110	R:R:Y61	8.23	Yes	Yes	0	7	8
14	R:R:V314	R:R:Y61	3.79	No	Yes	0	5	8
15	R:R:I111	R:R:S62	3.1	No	No	0	7	6
16	R:R:I64	R:R:S317	3.1	Yes	No	0	7	7
17	R:R:C321	R:R:I64	3.27	No	Yes	0	7	7
18	R:R:F65	R:R:P108	11.56	No	No	0	7	9
19	R:R:C321	R:R:V67	3.42	No	No	0	7	6
20	R:R:I73	R:R:L69	7.14	No	No	0	3	6
21	R:R:N72	R:R:P324	4.89	No	No	0	9	9
22	R:R:F79	R:R:L93	4.87	No	Yes	2	6	8
23	R:R:F79	R:R:L94	10.96	No	No	0	6	6
24	R:R:F79	R:R:Y327	5.16	No	Yes	2	6	9
25	R:R:L80	R:R:L94	4.15	No	No	0	3	6
26	R:R:H83	R:R:Q90	13.6	No	No	0	5	7
27	R:R:Q90	R:R:R86	4.67	No	No	0	7	7
28	R:R:N87	R:R:S88	2.98	No	No	4	8	6
29	R:R:K155	R:R:N87	5.6	No	No	0	8	8
30	R:R:N87	R:R:T168	4.39	No	No	4	8	4
31	R:R:S88	R:R:T168	4.8	No	No	4	6	4
32	R:R:S171	R:R:S88	4.89	Yes	No	0	7	6
33	R:R:I89	R:R:L93	2.85	No	Yes	0	7	8
34	R:R:D151	R:R:I89	4.2	No	No	0	8	7
35	R:R:I89	R:R:R152	5.01	No	No	0	7	9
36	R:R:I91	R:R:S171	4.64	No	Yes	0	6	7
37	R:R:F147	R:R:Y92	7.22	No	Yes	0	5	7
38	R:R:I148	R:R:Y92	4.84	No	Yes	0	9	7
39	R:R:S171	R:R:Y92	5.09	Yes	Yes	0	7	7
40	R:R:V174	R:R:Y92	3.79	No	Yes	0	5	7
41	R:R:I148	R:R:L93	2.85	No	Yes	0	9	8
42	R:R:L93	R:R:Y327	3.52	Yes	Yes	2	8	9
43	R:R:I98	R:R:L94	4.28	No	No	0	5	6
44	R:R:C175	R:R:N95	6.3	No	No	0	6	9
45	R:R:L144	R:R:V96	4.47	No	No	0	7	9
46	R:R:D100	R:R:S141	4.42	No	No	0	9	9
47	R:R:D100	R:R:S320	7.36	No	No	0	9	8
48	R:R:L102	R:R:N137	4.12	No	No	0	7	8
49	R:R:F134	R:R:L103	6.09	No	No	0	7	7
50	R:R:L103	R:R:N137	6.87	No	No	0	7	8
51	R:R:C106	R:R:F134	4.19	No	No	0	6	7
52	R:R:L107	R:R:S317	3	No	No	0	7	7
53	R:R:F109	R:R:V130	5.24	No	No	0	6	5
54	R:R:H114	R:R:R110	4.51	No	Yes	0	5	7
55	R:R:F205	R:R:R110	19.24	Yes	Yes	0	4	7
56	R:R:E310	R:R:R110	9.3	No	Yes	0	5	7
57	R:R:H114	R:R:Y113	9.8	No	No	0	5	5
58	R:R:W120	R:R:Y113	3.86	Yes	No	0	9	5
59	R:R:F205	R:R:Y113	3.09	Yes	No	0	4	5
60	R:R:N118	R:R:Q117	3.96	No	No	0	4	3
61	R:R:K119	R:R:N118	6.99	No	No	0	4	4
62	R:R:L122	R:R:W120	9.11	No	Yes	0	7	9
63	R:R:C204	R:R:W120	18.28	No	Yes	0	9	9
64	R:R:L122	R:R:T121	2.95	No	No	0	7	3
65	R:R:G123	R:R:S201	3.71	No	No	0	7	4
66	R:R:I125	R:R:V124	3.07	No	No	0	1	4
67	R:R:H199	R:R:V124	4.15	No	No	0	3	4
68	R:R:S201	R:R:V124	3.23	No	No	0	4	4
69	R:R:C127	R:R:C204	7.28	No	No	5	9	9
70	R:R:C127	R:R:F205	5.59	No	Yes	5	9	4
71	R:R:K128	R:R:T193	7.51	No	No	0	8	5
72	R:R:K128	R:R:R208	4.95	No	No	1	8	5
73	L:L:?1	R:R:K128	4.96	Yes	No	1	0	8
74	R:R:I190	R:R:V129	3.07	No	No	0	5	5
75	R:R:F205	R:R:V130	3.93	Yes	No	0	4	5
76	R:R:F186	R:R:T132	6.49	Yes	Yes	1	7	5
77	R:R:M189	R:R:T132	3.01	No	Yes	1	4	5
78	R:R:I190	R:R:T132	4.56	No	Yes	1	5	5
79	L:L:?1	R:R:T132	9.07	Yes	Yes	1	0	5
80	R:R:F186	R:R:L133	4.87	Yes	No	0	7	5
81	R:R:Y135	R:R:Y282	4.96	No	Yes	1	5	6
82	R:R:R286	R:R:Y135	5.14	Yes	No	1	6	5
83	L:L:?1	R:R:Y135	22.67	Yes	No	1	0	5
84	R:R:A182	R:R:M136	3.22	No	No	0	7	5
85	L:L:?1	R:R:M136	4.97	Yes	No	0	0	5
86	R:R:M138	R:R:Y282	7.18	No	Yes	0	7	6
87	R:R:L223	R:R:Y139	12.89	No	No	0	5	7
88	R:R:H283	R:R:Y139	4.36	No	No	0	8	7
89	R:R:I140	R:R:L144	2.85	Yes	No	0	7	7
90	R:R:A182	R:R:I140	3.25	No	Yes	0	7	7
91	R:R:F227	R:R:I142	6.28	Yes	No	3	8	8
92	R:R:F279	R:R:I142	6.28	Yes	No	3	8	8
93	R:R:F147	R:R:I143	3.77	No	Yes	0	5	5
94	R:R:I143	R:R:M226	5.83	Yes	No	0	5	5
95	R:R:I143	R:R:I230	2.94	Yes	No	0	5	9
96	L:L:?1	R:R:I143	3.76	Yes	Yes	0	0	5
97	R:R:D323	R:R:L145	5.43	No	No	0	9	8
98	R:R:G146	R:R:I234	3.53	No	Yes	0	7	8
99	R:R:I148	R:R:R152	5.01	No	No	0	9	9
100	R:R:I234	R:R:S149	9.29	Yes	No	0	8	9
101	R:R:S149	R:R:S237	3.26	No	No	0	9	6
102	R:R:S149	R:R:Y238	7.63	No	Yes	0	9	8
103	R:R:L150	R:R:L233	6.92	No	No	0	5	7
104	R:R:R152	R:R:Y238	4.12	No	Yes	0	9	8
105	R:R:N157	R:R:Y153	6.98	No	No	0	7	7
106	R:R:S237	R:R:Y153	7.63	No	No	0	6	7
107	R:R:K240	R:R:Y153	3.58	No	No	0	4	7
108	R:R:I156	R:R:I241	5.89	No	No	0	8	8
109	R:R:N157	R:R:N244	8.17	No	No	0	7	5
110	R:R:K164	R:R:R158	4.95	No	No	0	3	5
111	R:R:K164	R:R:T167	9.01	No	No	0	3	6
112	R:R:I172	R:R:K169	2.91	No	No	0	4	4
113	L:L:?1	R:R:L181	3.65	Yes	No	0	0	4
114	R:R:F186	R:R:L187	3.65	Yes	No	0	7	4
115	R:R:F186	R:R:I190	6.28	Yes	No	1	7	5
116	R:R:F219	R:R:M189	3.73	No	No	1	5	4
117	L:L:?1	R:R:M189	8.7	Yes	No	1	0	4
118	R:R:A213	R:R:K196	4.82	No	No	0	1	3
119	R:R:G197	R:R:H199	3.18	No	No	0	1	3
120	R:R:N200	R:R:T202	8.77	No	No	0	5	4
121	R:R:M203	R:R:N200	4.21	No	No	0	4	5
122	R:R:M203	R:R:R208	4.96	No	No	0	4	5
123	R:R:C204	R:R:F205	5.59	No	Yes	5	9	4
124	R:R:Y207	R:R:Y289	6.95	Yes	Yes	1	3	4
125	R:R:S292	R:R:Y207	3.82	No	Yes	1	3	3
126	R:R:Q293	R:R:Y207	9.02	No	Yes	1	4	3
127	R:R:K302	R:R:Y207	5.97	Yes	Yes	1	4	3
128	R:R:H306	R:R:Y207	7.62	No	Yes	0	4	3
129	L:L:?1	R:R:R208	8.54	Yes	No	1	0	5
130	R:R:D209	R:R:K210	8.3	No	No	0	5	3
131	R:R:K210	R:R:N212	15.39	No	No	0	3	2
132	R:R:E216	R:R:H211	3.69	No	No	0	3	4
133	R:R:A217	R:R:H211	8.78	No	No	0	4	4
134	R:R:H211	R:R:Q293	11.13	No	No	0	4	4
135	L:L:?1	R:R:F219	9.64	Yes	No	1	0	5
136	R:R:N220	R:R:R286	4.82	No	Yes	1	4	6
137	R:R:I290	R:R:N220	4.25	No	No	0	5	4
138	L:L:?1	R:R:N220	10.86	Yes	No	1	0	4
139	R:R:F221	R:R:F287	3.22	No	No	0	4	6
140	L:L:?1	R:R:L223	8.52	Yes	No	0	0	5
141	R:R:F287	R:R:V224	3.93	No	No	0	6	4
142	R:R:F227	R:R:F275	4.29	Yes	Yes	3	8	9
143	R:R:F227	R:R:F279	6.43	Yes	Yes	3	8	8
144	R:R:F227	R:R:H283	30.55	Yes	No	0	8	8
145	R:R:F287	R:R:W228	5.01	No	No	0	6	5
146	R:R:I230	R:R:I234	2.94	No	Yes	0	9	8
147	R:R:F231	R:R:I235	8.79	Yes	No	0	7	4
148	R:R:F231	R:R:F275	5.36	Yes	Yes	0	7	9
149	R:R:F231	R:R:T276	7.78	Yes	No	0	7	5
150	R:R:F231	R:R:V280	5.24	Yes	No	0	7	5
151	R:R:F275	R:R:I234	3.77	Yes	Yes	0	9	8
152	R:R:I235	R:R:L272	5.71	No	Yes	0	4	7
153	R:R:I241	R:R:S237	3.1	No	No	0	8	6
154	R:R:S268	R:R:Y238	6.36	No	Yes	0	7	8
155	R:R:V271	R:R:Y238	3.79	No	Yes	0	7	8
156	R:R:L272	R:R:Y238	7.03	Yes	Yes	0	7	8
157	R:R:G242	R:R:I241	3.53	No	No	0	4	8
158	R:R:F269	R:R:G242	3.01	No	No	0	4	4
159	R:R:N244	R:R:R247	6.03	No	Yes	0	5	5
160	R:R:L245	R:R:T263	5.9	No	No	0	8	7
161	R:R:L245	R:R:T264	8.84	No	Yes	0	8	7
162	R:R:L246	R:R:T264	4.42	No	Yes	0	3	7
163	R:R:I248	R:R:R247	8.77	No	Yes	0	6	5
164	R:R:I248	R:R:R252	3.76	No	No	0	6	4
165	R:R:N257	R:R:R252	3.62	No	No	0	4	4
166	R:R:K260	R:R:R252	3.71	No	No	0	5	4
167	R:R:F255	R:R:P256	2.89	No	No	0	3	3
168	R:R:F255	R:R:N257	4.83	No	No	0	3	4
169	R:R:N267	R:R:T263	4.39	No	No	0	7	7
170	R:R:M330	R:R:N267	9.82	No	No	0	6	7
171	R:R:L272	R:R:T276	2.95	Yes	No	0	7	5
172	R:R:I273	R:R:I277	2.94	No	No	0	4	5
173	R:R:F275	R:R:F279	11.79	Yes	Yes	3	9	8
174	R:R:C278	R:R:L315	6.35	No	No	0	7	7
175	R:R:C278	R:R:N319	9.45	No	No	0	7	9
176	R:R:F279	R:R:N319	14.5	Yes	No	0	8	9
177	R:R:P281	R:R:V280	3.53	No	No	0	9	5
178	R:R:M312	R:R:P281	3.35	No	No	0	6	9
179	R:R:H283	R:R:Y282	5.44	No	Yes	0	8	6
180	R:R:R286	R:R:Y282	9.26	Yes	Yes	1	6	6
181	R:R:M312	R:R:Y282	3.59	No	Yes	0	6	6
182	R:R:L313	R:R:Y282	11.72	No	Yes	0	5	6
183	R:R:S316	R:R:Y282	6.36	No	Yes	0	7	6
184	R:R:F285	R:R:V305	5.24	No	No	0	5	4
185	R:R:F285	R:R:T308	15.56	No	No	0	5	5
186	R:R:F285	R:R:M312	3.73	No	No	0	5	6
187	R:R:R286	R:R:Y289	5.14	Yes	Yes	1	6	4
188	R:R:N309	R:R:R286	6.03	Yes	Yes	1	5	6
189	L:L:?1	R:R:R286	5.34	Yes	Yes	1	0	6
190	R:R:I288	R:R:S291	3.1	No	No	0	5	4
191	R:R:Q293	R:R:Y289	11.27	No	Yes	1	4	4
192	R:R:N309	R:R:Y289	13.96	Yes	Yes	1	5	4
193	L:L:?1	R:R:Y289	12.37	Yes	Yes	1	0	4
194	R:R:K302	R:R:S292	6.12	Yes	No	1	4	3
195	R:R:S297	R:R:S298	3.26	No	No	0	2	5
196	R:R:S297	R:R:W301	3.71	No	Yes	1	2	1
197	R:R:K302	R:R:S297	4.59	Yes	No	1	4	2
198	R:R:I304	R:R:Y300	4.84	No	No	0	3	2
199	R:R:K302	R:R:W301	5.8	Yes	Yes	1	4	1
200	R:R:I304	R:R:W301	3.52	No	Yes	0	3	1
201	R:R:E303	R:R:K307	6.75	No	No	0	1	3
202	R:R:L313	R:R:N309	4.12	No	Yes	0	5	5
203	L:L:?1	R:R:N309	7.24	Yes	Yes	1	0	5
204	R:R:F318	R:R:L322	10.96	No	No	0	5	6
205	R:R:D323	R:R:P324	3.22	No	No	0	9	9
206	R:R:D323	R:R:M326	4.16	No	No	0	9	7
207	R:R:F328	R:R:V325	5.24	Yes	No	0	6	6
208	R:R:S331	R:R:Y327	3.82	No	Yes	2	8	9
209	R:R:I334	R:R:Y327	7.25	Yes	Yes	2	8	9
210	R:R:N333	R:R:S331	5.96	No	No	2	6	8
211	R:R:I334	R:R:S331	6.19	Yes	No	2	8	8
212	R:R:K336	R:R:S332	6.12	No	No	0	5	5
213	R:R:I334	R:R:N333	8.5	Yes	No	2	8	6
214	R:R:G123	R:R:W120	2.81	No	Yes	0	7	9
215	R:R:M136	R:R:N137	2.8	No	No	0	5	8
216	R:R:L53	R:R:L57	2.77	No	Yes	0	5	5
217	R:R:A75	R:R:F328	2.77	No	Yes	0	8	6
218	R:R:H83	R:R:V78	2.77	No	No	0	5	7
219	R:R:D100	R:R:N72	2.69	No	No	0	9	9
220	R:R:H83	R:R:I334	2.65	No	Yes	0	5	8
221	R:R:E216	R:R:L192	2.65	No	No	0	3	4
222	R:R:R335	R:R:S332	2.64	No	No	0	8	5
223	R:R:R286	R:R:V224	2.62	Yes	No	0	6	4
224	R:R:F65	R:R:I104	2.51	No	No	0	7	5
225	R:R:F105	R:R:L101	2.44	No	No	0	5	7
226	R:R:F275	R:R:L145	2.44	Yes	No	0	9	8
227	R:R:I111	R:R:Y61	2.42	No	Yes	0	7	8
228	R:R:L183	R:R:W179	2.28	No	No	0	4	9
229	R:R:R247	R:R:R251	2.13	Yes	No	0	5	4
230	R:R:G184	R:R:G185	2.11	No	No	0	3	4
231	R:R:G197	R:R:G198	2.11	No	No	0	1	1
232	R:R:C321	R:R:G68	1.96	No	No	0	7	8
233	R:R:G259	R:R:S258	1.86	No	No	0	4	4
234	R:R:G71	R:R:V70	1.84	No	No	0	8	4
235	R:R:G185	R:R:T188	1.82	No	No	0	4	8
236	R:R:G242	R:R:T264	1.82	No	Yes	0	4	7
237	R:R:G68	R:R:I104	1.76	No	No	0	8	5
238	R:R:G215	R:R:I218	1.76	No	No	0	3	5
239	R:R:G197	R:R:K196	1.74	No	No	0	1	3
240	R:R:G215	R:R:K214	1.74	No	No	0	3	2
241	R:R:A284	R:R:V280	1.7	No	No	0	6	5
242	R:R:A265	R:R:T264	1.68	No	Yes	0	5	7
243	R:R:C175	R:R:I91	1.64	No	No	0	6	6
244	R:R:E216	R:R:G215	1.64	No	No	0	3	3
245	R:R:C278	R:R:I277	1.64	No	No	0	7	5
246	R:R:A99	R:R:I140	1.62	No	Yes	0	8	7
247	R:R:C176	R:R:M180	1.62	No	No	0	4	4
248	R:R:A217	R:R:L294	1.58	No	No	0	4	1
249	R:R:T55	R:R:T58	1.57	No	No	0	5	5
250	R:R:T58	R:R:T59	1.57	No	No	0	5	5
251	R:R:A97	R:R:N72	1.56	No	No	0	9	9
252	R:R:I172	R:R:S171	1.55	No	Yes	0	4	7
253	R:R:I74	R:R:V70	1.54	No	No	0	5	4
254	R:R:I140	R:R:V178	1.54	Yes	No	0	7	7
255	R:R:I143	R:R:V178	1.54	Yes	No	0	5	7
256	R:R:I270	R:R:V271	1.54	No	No	0	5	7
257	R:R:K260	R:R:S249	1.53	No	No	0	5	3
258	R:R:I115	R:R:T58	1.52	No	No	0	4	5
259	R:R:F134	R:R:G131	1.51	No	No	0	7	6
260	R:R:L57	R:R:V56	1.49	Yes	No	0	5	5
261	R:R:L322	R:R:V325	1.49	No	No	0	6	6
262	R:R:L194	R:R:T193	1.47	No	No	0	4	5
263	R:R:I270	R:R:I274	1.47	No	No	0	5	6
264	R:R:I274	R:R:I277	1.47	No	No	0	6	5
265	R:R:I154	R:R:K164	1.45	No	No	0	6	3
266	R:R:I98	R:R:L76	1.43	No	No	0	5	7
267	R:R:Q170	R:R:V174	1.43	No	No	0	3	5
268	R:R:I177	R:R:L181	1.43	No	No	0	3	4
269	R:R:I235	R:R:L232	1.43	No	No	0	4	2
270	R:R:I239	R:R:L272	1.43	No	Yes	0	3	7
271	R:R:K240	R:R:L236	1.41	No	No	0	4	4
272	R:R:L101	R:R:L76	1.38	No	No	0	7	7
273	R:R:K51	R:R:Q117	1.36	No	No	0	4	3
274	R:R:A99	R:R:W179	1.3	No	No	0	8	9
275	R:R:Q161	R:R:Q162	1.28	No	No	0	4	5
276	R:R:S249	R:R:Y261	1.27	No	No	0	3	6
277	R:R:F318	R:R:I64	1.26	No	Yes	0	5	7
278	R:R:F328	R:R:I334	1.26	Yes	Yes	0	6	8
279	R:R:I160	R:R:R247	1.25	No	Yes	0	5	5
280	R:R:F65	R:R:L69	1.22	No	No	0	7	6
281	R:R:F328	R:R:L329	1.22	Yes	No	0	6	6
282	R:R:I288	R:R:W301	1.17	No	Yes	0	5	1
283	R:R:L126	R:R:W120	1.14	No	Yes	0	5	9
284	R:R:Q170	R:R:Y173	1.13	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L57	3.6875	4	0	5
2	R:R:Y61	4.7825	4	0	8
3	R:R:I64	2.6825	4	0	7
4	R:R:Y92	5.235	4	0	7
5	R:R:L93	3.5225	4	2	8
6	R:R:R110	10.32	4	0	7
7	R:R:W120	7.04	5	0	9
8	R:R:T132	5.7825	4	1	5
9	R:R:I140	2.315	4	0	7
10	R:R:I143	3.568	5	0	5
11	R:R:S171	4.0425	4	0	7
12	R:R:F186	5.3225	4	1	7
13	R:R:F205	7.488	5	5	4
14	R:R:Y207	6.676	5	1	3
15	R:R:F227	11.8875	4	3	8
16	R:R:F231	6.7925	4	0	7
17	R:R:I234	4.8825	4	0	8
18	R:R:Y238	5.786	5	0	8
19	R:R:R247	4.545	4	0	5
20	R:R:T264	4.19	4	0	7
21	R:R:L272	4.28	4	0	7
22	R:R:F275	5.53	5	3	9
23	R:R:F279	9.75	4	3	8
24	R:R:Y282	6.93	7	1	6
25	R:R:R286	5.47857	7	1	6
26	R:R:Y289	9.938	5	1	4
27	R:R:W301	3.55	4	1	1
28	R:R:K302	5.62	4	1	4
29	R:R:N309	7.8375	4	1	5
30	R:R:Y327	4.9375	4	2	9
31	R:R:F328	2.6225	4	0	6
32	R:R:I334	5.17	5	2	8
33	L:L:?1	8.59214	14	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E303	R:R:E50	90.6682	6.34	No	No	0	1	4
2	R:R:E303	R:R:K307	89.8385	6.75	No	No	0	1	3
3	R:R:K307	R:R:L53	89.1337	5.64	No	No	0	3	5
4	R:R:L53	R:R:L57	88.6431	2.77	No	Yes	0	5	5
5	R:R:L57	R:R:V56	16.7633	1.49	Yes	No	0	5	5
6	R:R:T59	R:R:V56	13.4446	3.17	No	No	0	5	5
7	R:R:H114	R:R:L57	61.3168	3.86	No	Yes	0	5	5
8	R:R:E310	R:R:L57	26.7285	6.63	No	Yes	0	5	5
9	R:R:H114	R:R:R110	35.9711	4.51	No	Yes	0	5	7
10	R:R:R110	R:R:Y61	68.1149	8.23	Yes	Yes	0	7	8
11	R:R:L107	R:R:Y61	33.5088	4.69	No	Yes	0	7	8
12	R:R:L107	R:R:S317	32.8575	3	No	No	0	7	7
13	R:R:I64	R:R:S317	33.2501	3.1	Yes	No	0	7	7
14	R:R:E310	R:R:R110	25.8899	9.3	No	Yes	0	5	7
15	R:R:V314	R:R:Y61	33.7764	3.79	No	Yes	0	5	8
16	R:R:S60	R:R:V314	33.1252	3.23	No	No	0	5	5
17	R:R:I64	R:R:S60	33.2411	3.1	Yes	No	0	7	5
18	R:R:I111	R:R:Y61	10.554	2.42	No	Yes	0	7	8
19	R:R:C321	R:R:I64	34.5347	3.27	No	Yes	0	7	7
20	R:R:C321	R:R:G68	26.0059	1.96	No	No	0	7	8
21	R:R:G68	R:R:I104	21.7147	1.76	No	No	0	8	5
22	R:R:F65	R:R:I104	17.4057	2.51	No	No	0	7	5
23	R:R:E50	R:R:H306	92.39	4.92	No	No	0	4	4
24	R:R:H306	R:R:Y207	93.1662	7.62	No	Yes	0	4	3
25	R:R:Y207	R:R:Y289	93.5587	6.95	Yes	Yes	1	3	4
26	R:R:R286	R:R:Y289	30.2346	5.14	Yes	Yes	1	6	4
27	R:R:R286	R:R:Y282	37.1576	9.26	Yes	Yes	1	6	6
28	R:R:H283	R:R:Y282	27.2192	5.44	No	Yes	0	8	6
29	R:R:F227	R:R:H283	28.4057	30.55	Yes	No	0	8	8
30	R:R:F227	R:R:F275	18.1997	4.29	Yes	Yes	3	8	9
31	R:R:F275	R:R:L145	28.6555	2.44	Yes	No	0	9	8
32	R:R:D323	R:R:L145	25.542	5.43	No	No	0	9	8
33	R:R:D323	R:R:P324	19.2613	3.22	No	No	0	9	9
34	R:R:N72	R:R:P324	16.0942	4.89	No	No	0	9	9
35	L:L:?1	R:R:Y289	77.9374	12.37	Yes	Yes	1	0	4
36	L:L:?1	R:R:I143	100	3.76	Yes	Yes	0	0	5
37	R:R:I143	R:R:I230	57.3646	2.94	Yes	No	0	5	9
38	R:R:I230	R:R:I234	56.2762	2.94	No	Yes	0	9	8
39	R:R:F275	R:R:I234	40.1463	3.77	Yes	Yes	0	9	8
40	R:R:F147	R:R:I143	50.7182	3.77	No	Yes	0	5	5
41	R:R:F147	R:R:Y92	49.6298	7.22	No	Yes	0	5	7
42	R:R:I148	R:R:Y92	43.7684	4.84	No	Yes	0	9	7
43	R:R:I148	R:R:L93	61.4417	2.85	No	Yes	0	9	8
44	R:R:F79	R:R:L93	15.666	4.87	No	Yes	2	6	8
45	R:R:F79	R:R:L94	21.8307	10.96	No	No	0	6	6
46	R:R:L93	R:R:Y327	72.415	3.52	Yes	Yes	2	8	9
47	R:R:I334	R:R:Y327	76.7687	7.25	Yes	Yes	2	8	9
48	R:R:H83	R:R:I334	14.4884	2.65	No	Yes	0	5	8
49	R:R:S171	R:R:Y92	23.838	5.09	Yes	Yes	0	7	7
50	R:R:I89	R:R:L93	31.1179	2.85	No	Yes	0	7	8
51	R:R:I148	R:R:R152	36.3369	5.01	No	No	0	9	9
52	R:R:I89	R:R:R152	29.735	5.01	No	No	0	7	9
53	R:R:I98	R:R:L94	14.6222	4.28	No	No	0	5	6
54	L:L:?1	R:R:M136	26.2289	4.97	Yes	No	0	0	5
55	R:R:I143	R:R:V178	16.576	1.54	Yes	No	0	5	7
56	R:R:I140	R:R:V178	14.4259	1.54	Yes	No	0	7	7
57	R:R:M136	R:R:N137	15.1396	2.8	No	No	0	5	8
58	R:R:L103	R:R:N137	10.1615	6.87	No	No	0	7	8
59	R:R:F205	R:R:R110	42.0287	19.24	Yes	Yes	0	4	7
60	R:R:F205	R:R:V130	12.9093	3.93	Yes	No	0	4	5
61	R:R:H114	R:R:Y113	44.5446	9.8	No	No	0	5	5
62	R:R:F205	R:R:Y113	18.6903	3.09	Yes	No	0	4	5
63	R:R:W120	R:R:Y113	43.5008	3.86	Yes	No	0	9	5
64	R:R:C204	R:R:W120	11.5175	18.28	No	Yes	0	9	9
65	R:R:C204	R:R:F205	15.9693	5.59	No	Yes	5	9	4
66	R:R:G123	R:R:W120	35.9354	2.81	No	Yes	0	7	9
67	R:R:G123	R:R:S201	31.9565	3.71	No	No	0	7	4
68	R:R:S201	R:R:V124	27.9597	3.23	No	No	0	4	4
69	R:R:H199	R:R:V124	19.9126	4.15	No	No	0	3	4
70	L:L:?1	R:R:T132	15.3537	9.07	Yes	Yes	1	0	5
71	L:L:?1	R:R:Y135	11.2856	22.67	Yes	No	1	0	5
72	R:R:I234	R:R:S149	57.32	9.29	Yes	No	0	8	9
73	R:R:S149	R:R:S237	65.7061	3.26	No	No	0	9	6
74	R:R:S149	R:R:Y238	48.2916	7.63	No	Yes	0	9	8
75	R:R:S237	R:R:Y153	39.2096	7.63	No	No	0	6	7
76	R:R:N157	R:R:Y153	32.0903	6.98	No	No	0	7	7
77	R:R:I241	R:R:S237	27.469	3.1	No	No	0	8	6
78	R:R:G197	R:R:H199	15.8623	3.18	No	No	0	1	3
79	R:R:K302	R:R:Y207	21.2775	5.97	Yes	Yes	1	4	3
80	R:R:E216	R:R:H211	13.2126	3.69	No	No	0	3	4
81	R:R:H211	R:R:Q293	21.0813	11.13	No	No	0	4	4
82	R:R:F231	R:R:F275	12.3829	5.36	Yes	Yes	0	7	9
83	R:R:M312	R:R:Y282	19.3238	3.59	No	Yes	0	6	6
84	R:R:M312	R:R:P281	10.0723	3.35	No	No	0	6	9
85	R:R:P281	R:R:V280	10.0633	3.53	No	No	0	9	5
86	R:R:F231	R:R:V280	12.2937	5.24	Yes	No	0	7	5
87	R:R:L272	R:R:Y238	16.1834	7.03	Yes	Yes	0	7	8
88	R:R:V271	R:R:Y238	11.7495	3.79	No	Yes	0	7	8
89	R:R:G242	R:R:I241	22.7317	3.53	No	No	0	4	8
90	R:R:N157	R:R:N244	29.6547	8.17	No	No	0	7	5
91	R:R:N244	R:R:R247	27.4512	6.03	No	Yes	0	5	5
92	R:R:G242	R:R:T264	17.7536	1.82	No	Yes	0	4	7
93	R:R:L245	R:R:T264	10.1526	8.84	No	Yes	0	8	7
94	R:R:I248	R:R:R247	20.0553	8.77	No	Yes	0	6	5
95	R:R:I248	R:R:R252	17.5573	3.76	No	No	0	6	4
96	R:R:F279	R:R:N319	13.0252	14.5	Yes	No	0	8	9
97	R:R:F285	R:R:M312	10.331	3.73	No	No	0	5	6
98	R:R:K302	R:R:W301	13.4713	5.8	Yes	Yes	1	4	1
99	R:R:F318	R:R:I64	67.3298	1.26	No	Yes	0	5	7
100	R:R:F318	R:R:L322	67.8651	10.96	No	No	0	5	6
101	R:R:F328	R:R:I334	72.6648	1.26	Yes	Yes	0	6	8
102	R:R:L322	R:R:V325	68.7483	1.49	No	No	0	6	6
103	R:R:F328	R:R:V325	69.6494	5.24	Yes	No	0	6	6
104	R:R:I98	R:R:L76	10.9912	1.43	No	No	0	5	7
105	R:R:A99	R:R:I140	10.2953	1.62	No	Yes	0	8	7
106	R:R:T58	R:R:T59	10.1079	1.57	No	No	0	5	5
107	R:R:R152	R:R:Y238	59.7377	4.12	No	Yes	0	9	8
108	L:L:?1	R:R:R286	15.2021	5.34	Yes	Yes	1	0	6
109	R:R:Q293	R:R:Y289	15.2556	11.27	No	Yes	1	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K128	R:R:T193	7.51	1	No	No	8	5	1	2
R:R:K128	R:R:R208	4.95	1	No	No	8	5	1	1
L:L:?1	R:R:K128	4.96	1	Yes	No	0	8	0	1
R:R:F186	R:R:T132	6.49	1	Yes	Yes	7	5	2	1
R:R:M189	R:R:T132	3.01	1	No	Yes	4	5	1	1
R:R:I190	R:R:T132	4.56	1	No	Yes	5	5	2	1
L:L:?1	R:R:T132	9.07	1	Yes	Yes	0	5	0	1
R:R:Y135	R:R:Y282	4.96	1	No	Yes	5	6	1	2
R:R:R286	R:R:Y135	5.14	1	Yes	No	6	5	1	1
L:L:?1	R:R:Y135	22.67	1	Yes	No	0	5	0	1
R:R:A182	R:R:M136	3.22	0	No	No	7	5	2	1
L:L:?1	R:R:M136	4.97	1	Yes	No	0	5	0	1
R:R:L223	R:R:Y139	12.89	0	No	No	5	7	1	2
R:R:F147	R:R:I143	3.77	0	No	Yes	5	5	2	1
R:R:I143	R:R:M226	5.83	0	Yes	No	5	5	1	2
R:R:I143	R:R:I230	2.94	0	Yes	No	5	9	1	2
L:L:?1	R:R:I143	3.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L181	3.65	1	Yes	No	0	4	0	1
R:R:F186	R:R:I190	6.28	1	Yes	No	7	5	2	2
R:R:F219	R:R:M189	3.73	1	No	No	5	4	1	1
L:L:?1	R:R:M189	8.7	1	Yes	No	0	4	0	1
R:R:M203	R:R:R208	4.96	0	No	No	4	5	2	1
R:R:Y207	R:R:Y289	6.95	1	Yes	Yes	3	4	2	1
R:R:Q293	R:R:Y207	9.02	1	No	Yes	4	3	2	2
L:L:?1	R:R:R208	8.54	1	Yes	No	0	5	0	1
L:L:?1	R:R:F219	9.64	1	Yes	No	0	5	0	1
R:R:N220	R:R:R286	4.82	1	No	Yes	4	6	1	1
R:R:I290	R:R:N220	4.25	0	No	No	5	4	2	1
L:L:?1	R:R:N220	10.86	1	Yes	No	0	4	0	1
L:L:?1	R:R:L223	8.52	1	Yes	No	0	5	0	1
R:R:R286	R:R:Y282	9.26	1	Yes	Yes	6	6	1	2
R:R:L313	R:R:Y282	11.72	0	No	Yes	5	6	2	2
R:R:R286	R:R:Y289	5.14	1	Yes	Yes	6	4	1	1
R:R:N309	R:R:R286	6.03	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:R286	5.34	1	Yes	Yes	0	6	0	1
R:R:Q293	R:R:Y289	11.27	1	No	Yes	4	4	2	1
R:R:N309	R:R:Y289	13.96	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:Y289	12.37	1	Yes	Yes	0	4	0	1
R:R:L313	R:R:N309	4.12	0	No	Yes	5	5	2	1
L:L:?1	R:R:N309	7.24	1	Yes	Yes	0	5	0	1
R:R:M136	R:R:N137	2.8	0	No	No	5	8	1	2
R:R:R286	R:R:V224	2.62	1	Yes	No	6	4	1	2
R:R:I143	R:R:V178	1.54	0	Yes	No	5	7	1	2
R:R:I177	R:R:L181	1.43	0	No	No	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8SAI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	261
Number of Links	284
Number of Hubs	33
Number of Links mediated by Hubs	131
Number of Communities	5
Number of Nodes involved in Communities	36
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	110
Number Of Links MetaPath	109
Number of Shortest Paths	41540
Length Of Smallest Path	3
Average Path Length	13.0728
Length of Longest Path	33
Minimum Path Strength	1.24
Average Path Strength	5.53659
Maximum Path Strength	18.49
Minimum Path Correlation	0.7
Average Path Correlation	0.92845
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	47.8877
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.8814
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	S12
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	S12
Name	O-[(S)-hydroxy{[(2S)-2-hydroxy-3-(octadec-9-enoyloxy)propyl]oxy}phosphoryl]-L-serine
Synonyms	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine
Identifier
Formula	C24 H46 N O9 P
Molecular Weight	523.597
SMILES
PubChem	137349977
Formal Charge	0
Total Atoms	81
Total Chiral Atoms	2
Total Bonds	80
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UPC5
Sequence	>8SAI_nogp_Chain_R M D E K L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H R K R N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q N K W T L G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S I Q Q R K A I T T K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G G H N S T M C F H Y R D K H N A K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K R R S K F P N S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S Q L N V S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N I R K I M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XBE	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ1	3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBE (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBG	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.43	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8SAI	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-	Gi1/β1/γ2	3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8SAI (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-		3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8IYX	A	Orphan	Orphan	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	doi.org/10.1073/pnas.2308435120
	8WRB	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8WRB (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8XBH	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ2	2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBH (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBI	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.06	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8K4N	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-	Gi1/β1/γ2	2.83	2023-10-25	To be published
	8K4N (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-		2.83	2023-10-25	To be published
	8IZ4	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.94	2024-04-10	To be published
	8IZ4 (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.94	2024-04-10	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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