psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K128	6.43	Yes	No	1	0	8
2	L:L:?1	R:R:Y135	12.21	Yes	Yes	1	0	5
3	L:L:?1	R:R:M136	9.2	Yes	No	0	0	5
4	L:L:?1	R:R:T193	4.8	Yes	No	1	0	5
5	L:L:?1	R:R:F205	4.76	Yes	Yes	0	0	4
6	L:L:?1	R:R:F219	7.14	Yes	No	0	0	5
7	L:L:?1	R:R:N220	10.73	Yes	No	0	0	4
8	L:L:?1	R:R:L223	6.31	Yes	No	0	0	5
9	L:L:?1	R:R:R286	6.33	Yes	Yes	1	0	6
10	L:L:?1	R:R:Y289	5.34	Yes	Yes	1	0	4
11	L:L:?1	R:R:N309	6.26	Yes	Yes	1	0	5
12	R:R:P47	R:R:T45	5.25	No	No	0	2	5
13	R:R:C299	R:R:C46	7.28	No	No	0	7	6
14	R:R:E303	R:R:M48	13.53	Yes	No	0	1	2
15	R:R:D49	R:R:K51	15.21	No	No	0	4	4
16	R:R:E50	R:R:N118	3.94	Yes	No	0	4	4
17	R:R:E303	R:R:E50	6.34	Yes	Yes	1	1	4
18	R:R:E50	R:R:H306	6.15	Yes	Yes	1	4	4
19	R:R:L52	R:R:L53	4.15	No	Yes	0	4	5
20	R:R:K307	R:R:L53	11.28	No	Yes	0	3	5
21	R:R:E310	R:R:L57	7.95	Yes	No	0	5	5
22	R:R:I115	R:R:T58	9.12	No	Yes	0	4	5
23	R:R:S60	R:R:V314	4.85	No	No	0	5	5
24	R:R:L107	R:R:Y61	4.69	No	Yes	0	7	8
25	R:R:R110	R:R:Y61	15.43	Yes	Yes	0	7	8
26	R:R:L313	R:R:Y61	4.69	Yes	Yes	0	5	8
27	R:R:S317	R:R:Y61	6.36	No	Yes	0	7	8
28	R:R:C321	R:R:I64	6.55	No	No	0	7	7
29	R:R:F65	R:R:I104	5.02	No	No	0	7	5
30	R:R:G68	R:R:V67	3.68	No	No	0	8	6
31	R:R:G68	R:R:I104	3.53	No	No	0	8	5
32	R:R:I73	R:R:L69	4.28	No	No	0	3	6
33	R:R:G71	R:R:P324	4.06	No	Yes	0	8	9
34	R:R:L101	R:R:N72	6.87	No	No	0	7	9
35	R:R:I104	R:R:N72	4.25	No	No	0	5	9
36	R:R:N72	R:R:P324	8.15	No	Yes	0	9	9
37	R:R:F328	R:R:I74	6.28	No	No	0	6	5
38	R:R:A75	R:R:P324	3.74	No	Yes	0	8	9
39	R:R:I98	R:R:L76	5.71	No	No	0	5	7
40	R:R:I82	R:R:V78	4.61	No	No	0	5	7
41	R:R:F79	R:R:Q90	9.37	Yes	No	0	6	7
42	R:R:F79	R:R:L93	7.31	Yes	No	0	6	8
43	R:R:F79	R:R:L94	3.65	Yes	No	0	6	6
44	R:R:F79	R:R:Y327	13.41	Yes	Yes	0	6	9
45	R:R:L80	R:R:L94	4.15	No	No	0	3	6
46	R:R:H83	R:R:I82	6.63	No	No	0	5	5
47	R:R:H83	R:R:Q90	21.02	No	No	0	5	7
48	R:R:H83	R:R:Y327	4.36	No	Yes	0	5	9
49	R:R:I91	R:R:R86	6.26	No	No	0	6	7
50	R:R:N87	R:R:S88	4.47	No	No	2	8	6
51	R:R:K155	R:R:N87	5.6	No	No	2	8	8
52	R:R:K155	R:R:S88	4.59	No	No	2	8	6
53	R:R:S88	R:R:T167	6.4	No	No	0	6	6
54	R:R:D151	R:R:I89	11.2	No	No	2	8	7
55	R:R:I89	R:R:R152	3.76	No	Yes	2	7	9
56	R:R:I89	R:R:K155	5.82	No	No	2	7	8
57	R:R:I91	R:R:S171	7.74	No	No	0	6	7
58	R:R:I172	R:R:I91	5.89	No	No	0	4	6
59	R:R:F147	R:R:Y92	13.41	No	Yes	4	5	7
60	R:R:I148	R:R:Y92	3.63	No	Yes	0	9	7
61	R:R:S171	R:R:Y92	8.9	No	Yes	0	7	7
62	R:R:V174	R:R:Y92	7.57	No	Yes	4	5	7
63	R:R:C175	R:R:Y92	4.03	No	Yes	0	6	7
64	R:R:I148	R:R:L93	4.28	No	No	0	9	8
65	R:R:C175	R:R:N95	7.87	No	No	0	6	9
66	R:R:N95	R:R:W179	7.91	No	No	0	9	9
67	R:R:D100	R:R:V96	4.38	No	No	0	9	9
68	R:R:L144	R:R:V96	4.47	No	No	0	7	9
69	R:R:D100	R:R:S141	8.83	No	No	0	9	9
70	R:R:D100	R:R:S320	11.78	No	No	0	9	8
71	R:R:F105	R:R:L101	7.31	No	No	0	5	7
72	R:R:L102	R:R:N137	8.24	No	No	0	7	8
73	R:R:F134	R:R:L103	7.31	No	No	0	7	7
74	R:R:L103	R:R:N137	6.87	No	No	0	7	8
75	R:R:C106	R:R:L133	4.76	No	No	0	6	5
76	R:R:F109	R:R:V130	6.55	No	No	0	6	5
77	R:R:H114	R:R:R110	7.9	Yes	Yes	1	5	7
78	R:R:F205	R:R:R110	17.1	Yes	Yes	0	4	7
79	R:R:E310	R:R:R110	5.82	Yes	Yes	1	5	7
80	R:R:H114	R:R:Y113	13.07	Yes	No	0	5	5
81	R:R:N118	R:R:Y113	10.47	No	No	0	4	5
82	R:R:F205	R:R:Y113	6.19	Yes	No	0	4	5
83	R:R:E310	R:R:H114	3.69	Yes	Yes	1	5	5
84	R:R:L122	R:R:W120	9.11	No	No	0	7	9
85	R:R:C127	R:R:W120	7.84	No	No	5	9	9
86	R:R:C204	R:R:W120	14.37	No	No	5	9	9
87	R:R:N200	R:R:V124	8.87	No	No	0	5	4
88	R:R:I125	R:R:L194	4.28	No	No	0	1	4
89	R:R:C127	R:R:C204	7.28	No	No	5	9	9
90	R:R:K128	R:R:T193	4.5	No	No	1	8	5
91	R:R:K128	R:R:L194	5.64	No	No	0	8	4
92	R:R:F205	R:R:G131	4.52	Yes	No	0	4	6
93	R:R:F186	R:R:T132	5.19	Yes	No	0	7	5
94	R:R:F134	R:R:Y135	6.19	No	Yes	1	7	5
95	R:R:F134	R:R:L313	3.65	No	Yes	1	7	5
96	R:R:Y135	R:R:Y282	5.96	Yes	Yes	1	5	6
97	R:R:R286	R:R:Y135	4.12	Yes	Yes	1	6	5
98	R:R:L313	R:R:Y135	4.69	Yes	Yes	1	5	5
99	R:R:F186	R:R:M136	4.98	Yes	No	0	7	5
100	R:R:M138	R:R:Y139	8.38	Yes	No	1	7	7
101	R:R:F279	R:R:M138	3.73	Yes	Yes	1	8	7
102	R:R:M138	R:R:Y282	4.79	Yes	Yes	1	7	6
103	R:R:H283	R:R:M138	3.94	Yes	Yes	1	8	7
104	R:R:M138	R:R:S316	4.6	Yes	No	1	7	7
105	R:R:L223	R:R:Y139	17.58	No	No	0	5	7
106	R:R:H283	R:R:Y139	7.62	Yes	No	1	8	7
107	R:R:F227	R:R:I142	8.79	Yes	No	1	8	8
108	R:R:F279	R:R:I142	12.56	Yes	No	1	8	8
109	R:R:D323	R:R:L145	5.43	No	No	0	9	8
110	R:R:G146	R:R:I234	3.53	No	No	0	7	8
111	R:R:F147	R:R:V174	7.87	No	No	4	5	5
112	R:R:I148	R:R:R152	7.52	No	Yes	0	9	9
113	R:R:I234	R:R:S149	10.84	No	No	0	8	9
114	R:R:S149	R:R:Y238	12.72	No	Yes	0	9	8
115	R:R:D151	R:R:R152	3.57	No	Yes	2	8	9
116	R:R:R152	R:R:Y238	8.23	Yes	Yes	0	9	8
117	R:R:N157	R:R:Y153	9.3	No	No	0	7	7
118	R:R:K240	R:R:Y153	10.75	No	No	0	4	7
119	R:R:I154	R:R:R158	3.76	No	No	0	6	5
120	R:R:N157	R:R:N244	16.35	No	No	0	7	5
121	R:R:Q161	R:R:Q162	6.4	No	No	0	4	5
122	R:R:I166	R:R:K164	5.82	No	No	0	7	3
123	R:R:Q170	R:R:T167	4.25	No	No	0	3	6
124	R:R:K169	R:R:Y173	4.78	No	No	0	4	2
125	R:R:F186	R:R:L183	3.65	Yes	No	0	7	4
126	R:R:F186	R:R:L187	4.87	Yes	No	0	7	4
127	R:R:E216	R:R:M189	4.06	Yes	No	0	3	4
128	R:R:F219	R:R:M189	8.71	No	No	0	5	4
129	R:R:E216	R:R:T193	4.23	Yes	No	0	3	5
130	R:R:H199	R:R:N212	17.86	No	No	0	3	2
131	R:R:M203	R:R:S201	4.6	No	No	0	4	4
132	R:R:C204	R:R:F205	6.98	No	Yes	0	9	4
133	R:R:H206	R:R:R208	4.51	No	No	0	5	5
134	R:R:Y207	R:R:Y289	5.96	Yes	Yes	1	3	4
135	R:R:S292	R:R:Y207	5.09	No	Yes	1	3	3
136	R:R:Q293	R:R:Y207	12.4	Yes	Yes	1	4	3
137	R:R:K302	R:R:Y207	15.53	No	Yes	0	4	3
138	R:R:H306	R:R:Y207	5.44	Yes	Yes	1	4	3
139	R:R:K210	R:R:Q293	6.78	No	Yes	0	3	4
140	R:R:K214	R:R:L294	5.64	No	No	0	2	1
141	R:R:A217	R:R:L294	4.73	No	No	0	4	1
142	R:R:F221	R:R:V225	3.93	No	No	0	4	5
143	R:R:R286	R:R:V224	3.92	Yes	No	0	6	4
144	R:R:F287	R:R:V224	5.24	No	No	0	6	4
145	R:R:F227	R:R:W228	4.01	Yes	No	0	8	5
146	R:R:F227	R:R:F279	5.36	Yes	Yes	1	8	8
147	R:R:F227	R:R:H283	37.33	Yes	Yes	1	8	8
148	R:R:F231	R:R:W228	4.01	Yes	No	0	7	5
149	R:R:F231	R:R:F275	6.43	Yes	No	0	7	9
150	R:R:F231	R:R:T276	5.19	Yes	No	0	7	5
151	R:R:F231	R:R:V280	5.24	Yes	No	0	7	5
152	R:R:F275	R:R:I234	8.79	No	No	0	9	8
153	R:R:I235	R:R:L272	4.28	No	No	0	4	7
154	R:R:S237	R:R:Y238	3.82	No	Yes	0	6	8
155	R:R:S268	R:R:Y238	3.82	No	Yes	0	7	8
156	R:R:V271	R:R:Y238	7.57	No	Yes	0	7	8
157	R:R:L272	R:R:Y238	8.21	No	Yes	0	7	8
158	R:R:I241	R:R:S268	6.19	No	No	0	8	7
159	R:R:G242	R:R:S268	3.71	No	No	0	4	7
160	R:R:F269	R:R:G242	4.52	No	No	0	4	4
161	R:R:N244	R:R:R247	4.82	No	No	0	5	5
162	R:R:I248	R:R:Y261	4.84	No	No	0	6	6
163	R:R:F255	R:R:R252	20.31	No	No	0	3	4
164	R:R:K254	R:R:P256	11.71	No	No	0	4	3
165	R:R:K260	R:R:N257	8.39	No	No	0	5	4
166	R:R:K260	R:R:Y261	13.14	No	No	0	5	6
167	R:R:N267	R:R:T263	4.39	No	No	0	7	7
168	R:R:I270	R:R:R266	6.26	No	No	0	5	6
169	R:R:M330	R:R:N267	8.41	No	No	0	6	7
170	R:R:M326	R:R:V271	9.13	No	No	0	7	7
171	R:R:I274	R:R:M326	7.29	No	No	0	6	7
172	R:R:F275	R:R:F279	9.65	No	Yes	0	9	8
173	R:R:C278	R:R:F318	5.59	No	No	0	7	5
174	R:R:F279	R:R:S316	5.28	Yes	No	1	8	7
175	R:R:F279	R:R:N319	8.46	Yes	No	0	8	9
176	R:R:P281	R:R:V280	3.53	No	No	0	9	5
177	R:R:H283	R:R:Y282	11.98	Yes	Yes	1	8	6
178	R:R:R286	R:R:Y282	12.35	Yes	Yes	1	6	6
179	R:R:N309	R:R:Y282	5.81	Yes	Yes	1	5	6
180	R:R:M312	R:R:Y282	5.99	No	Yes	0	6	6
181	R:R:L313	R:R:Y282	7.03	Yes	Yes	1	5	6
182	R:R:S316	R:R:Y282	5.09	No	Yes	1	7	6
183	R:R:F285	R:R:I288	6.28	No	No	0	5	5
184	R:R:F285	R:R:V305	6.55	No	No	0	5	4
185	R:R:F285	R:R:T308	3.89	No	No	0	5	5
186	R:R:R286	R:R:Y289	17.49	Yes	Yes	1	6	4
187	R:R:N309	R:R:R286	7.23	Yes	Yes	1	5	6
188	R:R:Q293	R:R:Y289	4.51	Yes	Yes	1	4	4
189	R:R:V305	R:R:Y289	3.79	No	Yes	0	4	4
190	R:R:N309	R:R:Y289	13.96	Yes	Yes	1	5	4
191	R:R:Q293	R:R:S292	5.78	Yes	No	1	4	3
192	R:R:K302	R:R:S297	9.18	No	No	0	4	2
193	R:R:I304	R:R:W301	4.7	No	No	0	3	1
194	R:R:V305	R:R:W301	6.13	No	No	0	4	1
195	R:R:E303	R:R:H306	3.69	Yes	Yes	1	1	4
196	R:R:E310	R:R:H306	8.62	Yes	Yes	1	5	4
197	R:R:F318	R:R:L322	6.09	No	No	0	5	6
198	R:R:D323	R:R:P324	4.83	No	Yes	0	9	9
199	R:R:M326	R:R:M330	4.33	No	No	0	7	6
200	R:R:S331	R:R:Y327	7.63	No	Yes	3	8	9
201	R:R:I334	R:R:Y327	8.46	Yes	Yes	3	8	9
202	R:R:F328	R:R:I334	5.02	No	Yes	0	6	8
203	R:R:N333	R:R:S331	8.94	No	No	3	6	8
204	R:R:I334	R:R:S331	6.19	Yes	No	3	8	8
205	R:R:I334	R:R:N333	7.08	Yes	No	3	8	6
206	R:R:L341	R:R:Q340	3.99	No	No	0	4	4
207	R:R:I98	R:R:W179	3.52	No	No	0	5	9
208	R:R:C321	R:R:V67	3.42	No	No	0	7	6
209	R:R:N257	R:R:P256	3.26	No	No	0	4	3
210	R:R:A99	R:R:I140	3.25	No	No	0	8	7
211	R:R:A182	R:R:I140	3.25	No	No	0	7	7
212	R:R:A217	R:R:K210	3.21	No	No	0	4	3
213	R:R:C278	R:R:N319	3.15	No	No	0	7	9
214	R:R:I111	R:R:S62	3.1	No	No	0	7	6
215	R:R:I64	R:R:S317	3.1	No	No	0	7	7
216	R:R:I125	R:R:V124	3.07	No	No	0	1	4
217	R:R:I190	R:R:V129	3.07	No	No	0	5	5
218	R:R:I143	R:R:V178	3.07	No	No	0	5	7
219	R:R:A213	R:R:E216	3.02	No	Yes	0	1	3
220	R:R:M189	R:R:T188	3.01	No	No	0	4	8
221	R:R:L103	R:R:S320	3	No	No	0	7	8
222	R:R:L145	R:R:S141	3	No	No	0	8	9
223	R:R:L322	R:R:V325	2.98	No	No	0	6	6
224	R:R:L122	R:R:T121	2.95	No	No	0	7	3
225	R:R:L245	R:R:T264	2.95	Yes	No	0	8	7
226	R:R:I142	R:R:I230	2.94	No	No	0	8	9
227	R:R:I143	R:R:I230	2.94	No	No	0	5	9
228	R:R:I230	R:R:M226	2.92	No	No	0	9	5
229	R:R:I270	R:R:M330	2.92	No	No	0	5	6
230	R:R:I218	R:R:K214	2.91	No	No	0	5	2
231	R:R:I125	R:R:L126	2.85	No	No	0	1	5
232	R:R:I140	R:R:L144	2.85	No	No	0	7	7
233	R:R:I191	R:R:L192	2.85	No	No	0	4	4
234	R:R:I239	R:R:L272	2.85	No	No	0	3	7
235	R:R:I290	R:R:N220	2.83	No	No	0	5	4
236	R:R:L150	R:R:L233	2.77	No	No	0	5	7
237	R:R:H114	R:R:T58	2.74	Yes	Yes	0	5	5
238	R:R:I337	R:R:Q340	2.74	No	No	0	4	4
239	R:R:K119	R:R:Q117	2.71	No	No	0	4	3
240	R:R:K169	R:R:Q170	2.71	No	No	0	4	3
241	R:R:E50	R:R:K307	2.7	Yes	No	1	4	3
242	R:R:E303	R:R:K307	2.7	Yes	No	1	1	3
243	R:R:H206	R:R:M203	2.63	No	No	0	5	4
244	R:R:F287	R:R:V225	2.62	No	No	0	6	5
245	R:R:R163	R:R:T167	2.59	No	No	0	5	6
246	R:R:S237	R:R:Y153	2.54	No	No	0	6	7
247	R:R:D209	R:R:H211	2.52	No	No	0	5	4
248	R:R:I154	R:R:R163	2.51	No	No	0	6	5
249	R:R:F186	R:R:I190	2.51	Yes	No	0	7	5
250	R:R:F65	R:R:L69	2.44	No	No	0	7	6
251	R:R:I304	R:R:Y300	2.42	No	No	0	3	2
252	L:L:?1	R:R:G185	2.23	Yes	No	0	0	4
253	R:R:H206	R:R:Y207	2.18	No	Yes	0	5	3
254	R:R:G184	R:R:G185	2.11	No	No	0	3	4
255	R:R:G197	R:R:G198	2.11	No	No	0	1	1
256	R:R:C46	R:R:P47	1.88	No	No	0	6	2
257	R:R:G71	R:R:V70	1.84	No	No	0	8	4
258	R:R:A75	R:R:A97	1.79	No	No	0	8	9
259	R:R:G197	R:R:K196	1.74	No	No	0	1	3
260	R:R:C106	R:R:V130	1.71	No	No	0	6	5
261	R:R:G123	R:R:L122	1.71	No	No	0	7	7
262	R:R:L107	R:R:P108	1.64	No	No	0	7	9
263	R:R:C176	R:R:I172	1.64	No	No	0	4	4
264	R:R:E216	R:R:G215	1.64	Yes	No	0	3	3
265	R:R:C278	R:R:I277	1.64	No	No	0	7	5
266	R:R:L315	R:R:P281	1.64	No	No	0	7	9
267	R:R:C176	R:R:M180	1.62	No	No	0	4	4
268	R:R:S54	R:R:T58	1.6	No	Yes	0	5	5
269	R:R:S62	R:R:T58	1.6	No	Yes	0	6	5
270	R:R:T55	R:R:V56	1.59	No	No	0	5	5
271	R:R:T59	R:R:V63	1.59	No	No	0	5	5
272	R:R:A265	R:R:L245	1.58	No	Yes	0	5	8
273	R:R:A265	R:R:L246	1.58	No	No	0	5	3
274	R:R:C106	R:R:N137	1.57	No	No	0	6	8
275	R:R:I66	R:R:V67	1.54	No	No	0	5	6
276	R:R:I66	R:R:V70	1.54	No	No	0	5	4
277	R:R:K254	R:R:S253	1.53	No	No	0	4	3
278	R:R:M203	R:R:T202	1.51	No	No	0	4	4
279	R:R:L53	R:R:V56	1.49	Yes	No	0	5	5
280	R:R:L57	R:R:V314	1.49	No	No	0	5	5
281	R:R:N295	R:R:S292	1.49	No	No	0	1	3
282	R:R:N333	R:R:S332	1.49	No	No	0	6	5
283	R:R:L192	R:R:T188	1.47	No	No	0	4	8
284	R:R:I190	R:R:I191	1.47	No	No	0	5	4
285	R:R:I218	R:R:I222	1.47	No	No	0	5	5
286	R:R:I273	R:R:I277	1.47	No	No	0	4	5
287	R:R:N87	R:R:T168	1.46	No	No	0	8	4
288	R:R:N116	R:R:T121	1.46	No	No	0	3	3
289	R:R:I239	R:R:K243	1.45	No	No	0	3	4
290	R:R:F255	R:R:P256	1.44	No	No	0	3	3
291	R:R:I311	R:R:L53	1.43	No	Yes	0	5	5
292	R:R:I311	R:R:L57	1.43	No	No	0	5	5
293	R:R:I156	R:R:L245	1.43	No	Yes	0	8	8
294	R:R:I177	R:R:L181	1.43	No	No	0	3	4
295	R:R:I241	R:R:L245	1.43	No	Yes	0	8	8
296	R:R:K195	R:R:L194	1.41	No	No	0	4	4
297	R:R:K240	R:R:L236	1.41	No	No	0	4	4
298	R:R:L232	R:R:L236	1.38	No	No	0	2	4
299	R:R:L341	R:R:L342	1.38	No	No	0	4	5
300	R:R:D49	R:R:L52	1.36	No	No	0	4	4
301	R:R:D209	R:R:N212	1.35	No	No	0	5	2
302	R:R:R252	R:R:S258	1.32	No	No	0	4	4
303	R:R:R335	R:R:S332	1.32	No	No	0	8	5
304	R:R:A284	R:R:W228	1.3	No	No	0	6	5
305	R:R:S249	R:R:Y261	1.27	No	No	0	3	6
306	R:R:S298	R:R:W301	1.24	No	No	0	5	1
307	R:R:L329	R:R:R335	1.21	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.81167	12	1	0
2	R:R:E50	4.7825	4	1	4
3	R:R:L53	4.5875	4	0	5
4	R:R:T58	3.765	4	0	5
5	R:R:Y61	7.7925	4	0	8
6	R:R:F79	8.435	4	0	6
7	R:R:Y92	7.508	5	4	7
8	R:R:R110	11.5625	4	1	7
9	R:R:H114	6.85	4	1	5
10	R:R:Y135	6.634	5	1	5
11	R:R:M138	5.088	5	1	7
12	R:R:R152	5.77	4	2	9
13	R:R:F186	4.24	5	0	7
14	R:R:F205	7.91	5	0	4
15	R:R:Y207	7.76667	6	1	3
16	R:R:E216	3.2375	4	0	3
17	R:R:F227	13.8725	4	1	8
18	R:R:F231	5.2175	4	0	7
19	R:R:Y238	7.395	6	0	8
20	R:R:L245	1.8475	4	0	8
21	R:R:F279	7.50667	6	1	8
22	R:R:Y282	7.375	8	1	6
23	R:R:H283	15.2175	4	1	8
24	R:R:R286	8.57333	6	1	6
25	R:R:Y289	8.50833	6	1	4
26	R:R:Q293	7.3675	4	1	4
27	R:R:E303	6.565	4	1	1
28	R:R:H306	5.975	4	1	4
29	R:R:N309	8.315	4	1	5
30	R:R:E310	6.52	4	1	5
31	R:R:L313	5.015	4	1	5
32	R:R:P324	5.195	4	0	9
33	R:R:Y327	8.465	4	3	9
34	R:R:I334	6.6875	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y207	R:R:Y289	25.0343	5.96	Yes	Yes	1	3	4
2	R:R:H306	R:R:Y207	17.1382	5.44	Yes	Yes	1	4	3
3	L:L:?1	R:R:F205	19.593	4.76	Yes	Yes	0	0	4
4	R:R:K307	R:R:L53	10.9277	11.28	No	Yes	0	3	5
5	L:L:?1	R:R:Y135	19.3873	12.21	Yes	Yes	1	0	5
6	R:R:L313	R:R:Y61	17.9894	4.69	Yes	Yes	0	5	8
7	R:R:R110	R:R:Y61	11.0063	15.43	Yes	Yes	0	7	8
8	R:R:S317	R:R:Y61	11.5163	6.36	No	Yes	0	7	8
9	R:R:I64	R:R:S317	10.7923	3.1	No	No	0	7	7
10	R:R:C321	R:R:I64	10.0699	6.55	No	No	0	7	7
11	R:R:F134	R:R:Y135	12.6668	6.19	No	Yes	1	7	5
12	R:R:F134	R:R:L103	20.7602	7.31	No	No	0	7	7
13	R:R:L103	R:R:S320	13.8072	3	No	No	0	7	8
14	R:R:D100	R:R:S320	12.8073	11.78	No	No	0	9	8
15	R:R:Y135	R:R:Y282	23.2384	5.96	Yes	Yes	1	5	6
16	R:R:M138	R:R:Y282	52.5819	4.79	Yes	Yes	1	7	6
17	R:R:F279	R:R:M138	59.4529	3.73	Yes	Yes	1	8	7
18	R:R:F275	R:R:F279	100	9.65	No	Yes	0	9	8
19	R:R:F275	R:R:I234	94.6239	8.79	No	No	0	9	8
20	R:R:I234	R:R:S149	92.6942	10.84	No	No	0	8	9
21	R:R:S149	R:R:Y238	91.7244	12.72	No	Yes	0	9	8
22	R:R:R152	R:R:Y238	61.3491	8.23	Yes	Yes	0	9	8
23	R:R:I148	R:R:R152	46.0954	7.52	No	Yes	0	9	9
24	R:R:I148	R:R:L93	28.9388	4.28	No	No	0	9	8
25	R:R:F79	R:R:L93	27.7683	7.31	Yes	No	0	6	8
26	R:R:F79	R:R:Y327	19.3923	13.41	Yes	Yes	0	6	9
27	L:L:?1	R:R:R286	15.2286	6.33	Yes	Yes	1	0	6
28	R:R:R286	R:R:Y282	34.8885	12.35	Yes	Yes	1	6	6
29	L:L:?1	R:R:N309	14.8891	6.26	Yes	Yes	1	0	5
30	R:R:N309	R:R:Y282	33.3149	5.81	Yes	Yes	1	5	6
31	R:R:S316	R:R:Y282	52.4431	5.09	No	Yes	1	7	6
32	R:R:F279	R:R:S316	52.1253	5.28	Yes	No	1	8	7
33	R:R:I148	R:R:Y92	17.1583	3.63	No	Yes	0	9	7
34	R:R:I89	R:R:R152	14.6467	3.76	No	Yes	2	7	9
35	R:R:I89	R:R:K155	13.5296	5.82	No	No	2	7	8
36	R:R:C204	R:R:F205	11.2003	6.98	No	Yes	0	9	4
37	L:L:?1	R:R:K128	11.4093	6.43	Yes	No	1	0	8
38	L:L:?1	R:R:M136	13.0999	9.2	Yes	No	0	0	5
39	R:R:F186	R:R:M136	11.4929	4.98	Yes	No	0	7	5
40	R:R:S268	R:R:Y238	10.9545	3.82	No	Yes	0	7	8
41	R:R:R286	R:R:Y289	20.3555	17.49	Yes	Yes	1	6	4
42	R:R:L313	R:R:Y282	23.5076	7.03	Yes	Yes	1	5	6
43	R:R:N309	R:R:Y289	18.1399	13.96	Yes	Yes	1	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K128	6.43	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y135	12.21	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M136	9.2	1	Yes	No	0	5	0	1
L:L:?1	R:R:T193	4.8	1	Yes	No	0	5	0	1
L:L:?1	R:R:F205	4.76	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F219	7.14	1	Yes	No	0	5	0	1
L:L:?1	R:R:N220	10.73	1	Yes	No	0	4	0	1
L:L:?1	R:R:L223	6.31	1	Yes	No	0	5	0	1
L:L:?1	R:R:R286	6.33	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y289	5.34	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:N309	6.26	1	Yes	Yes	0	5	0	1
R:R:F205	R:R:R110	17.1	0	Yes	Yes	4	7	1	2
R:R:F205	R:R:Y113	6.19	0	Yes	No	4	5	1	2
R:R:K128	R:R:T193	4.5	1	No	No	8	5	1	1
R:R:K128	R:R:L194	5.64	1	No	No	8	4	1	2
R:R:F205	R:R:G131	4.52	0	Yes	No	4	6	1	2
R:R:F134	R:R:Y135	6.19	1	No	Yes	7	5	2	1
R:R:F134	R:R:L313	3.65	1	No	Yes	7	5	2	2
R:R:Y135	R:R:Y282	5.96	1	Yes	Yes	5	6	1	2
R:R:R286	R:R:Y135	4.12	1	Yes	Yes	6	5	1	1
R:R:L313	R:R:Y135	4.69	1	Yes	Yes	5	5	2	1
R:R:F186	R:R:M136	4.98	0	Yes	No	7	5	2	1
R:R:L223	R:R:Y139	17.58	0	No	No	5	7	1	2
R:R:E216	R:R:M189	4.06	0	Yes	No	3	4	2	2
R:R:F219	R:R:M189	8.71	0	No	No	5	4	1	2
R:R:E216	R:R:T193	4.23	0	Yes	No	3	5	2	1
R:R:C204	R:R:F205	6.98	5	No	Yes	9	4	2	1
R:R:Y207	R:R:Y289	5.96	1	Yes	Yes	3	4	2	1
R:R:Q293	R:R:Y207	12.4	1	Yes	Yes	4	3	2	2
R:R:R286	R:R:V224	3.92	1	Yes	No	6	4	1	2
R:R:R286	R:R:Y282	12.35	1	Yes	Yes	6	6	1	2
R:R:N309	R:R:Y282	5.81	1	Yes	Yes	5	6	1	2
R:R:L313	R:R:Y282	7.03	1	Yes	Yes	5	6	2	2
R:R:R286	R:R:Y289	17.49	1	Yes	Yes	6	4	1	1
R:R:N309	R:R:R286	7.23	1	Yes	Yes	5	6	1	1
R:R:Q293	R:R:Y289	4.51	1	Yes	Yes	4	4	2	1
R:R:V305	R:R:Y289	3.79	0	No	Yes	4	4	2	1
R:R:N309	R:R:Y289	13.96	1	Yes	Yes	5	4	1	1
R:R:I290	R:R:N220	2.83	0	No	No	5	4	2	1
L:L:?1	R:R:G185	2.23	1	Yes	No	0	4	0	1
R:R:G184	R:R:G185	2.11	0	No	No	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XBE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	281
Number of Links	307
Number of Hubs	34
Number of Links mediated by Hubs	125
Number of Communities	5
Number of Nodes involved in Communities	43
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	44
Number Of Links MetaPath	43
Number of Shortest Paths	92715
Length Of Smallest Path	3
Average Path Length	14.2244
Length of Longest Path	28
Minimum Path Strength	1.265
Average Path Strength	7.15827
Maximum Path Strength	24.655
Minimum Path Correlation	0.7
Average Path Correlation	0.937869
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.7614
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3805
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KW0
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KW0
Name	(2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[(~{Z})-octadec-9-enoyl]oxy-propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid
Synonyms
Identifier
Formula	C26 H50 N O9 P
Molecular Weight	551.65
SMILES
PubChem	118584207
Formal Charge	0
Total Atoms	87
Total Chiral Atoms	2
Total Bonds	86
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UPC5
Sequence	>8XBE_nogp_Chain_R T C P M D E K L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H R K R N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q N K W T L G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S I Q Q R K A I T T K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G G H N S T M C F H Y R D K H N A K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K R R S K F P N S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S Q L N V S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N I R K I M C Q L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XBG	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.43	2024-05-15	10.1038/s41467-024-45046-z
	8XBE	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ1	3.4	2024-05-15	10.1038/s41467-024-45046-z
	8XBE (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		3.4	2024-05-15	10.1038/s41467-024-45046-z
	8IZ4	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.94	2024-04-10	To be published
	8IZ4 (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.94	2024-04-10	To be published
	8IYX	A	Orphan	Orphan	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	10.1073/pnas.2308435120
	8XBI	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	-	3.06	2023-12-27	To be published
	8XBH	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-	Gi1/β1/γ2	2.83	2023-12-27	To be published
	8XBH (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-LysoPS	-		2.83	2023-12-27	To be published
	8WRB	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-	Gi1/β1/γ2	2.91	2023-11-08	10.1371/journal.pbio.3002387
	8WRB (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine	-		2.91	2023-11-08	10.1371/journal.pbio.3002387
	8K4N	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-	Gi1/β1/γ2	2.83	2023-10-25	To be published
	8K4N (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	VF0	-		2.83	2023-10-25	To be published
	8SAI	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-	Gi1/β1/γ2	3.27	2023-10-04	10.1073/pnas.2308435120
	8SAI (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	-		3.27	2023-10-04	10.1073/pnas.2308435120

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XBE_nogp.zip

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