psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:S2	12.56	Yes	Yes	1	0	0
2	L:L:?1	R:R:T132	5.6	Yes	No	1	0	5
3	L:L:?1	R:R:Y135	8.91	Yes	Yes	1	0	5
4	L:L:?1	R:R:L181	4.21	Yes	No	0	0	4
5	L:L:?1	R:R:M189	6.45	Yes	No	1	0	4
6	L:L:?1	R:R:R208	9.24	Yes	Yes	0	0	5
7	L:L:?1	R:R:N220	11.48	Yes	No	0	0	4
8	L:L:?1	R:R:L223	8.42	Yes	No	0	0	5
9	L:L:?1	R:R:M226	7.52	Yes	No	0	0	5
10	L:L:S2	R:R:Y135	7.63	Yes	Yes	1	0	5
11	L:L:S2	R:R:R286	3.95	Yes	Yes	1	0	6
12	L:L:S2	R:R:Y289	3.82	Yes	Yes	1	0	4
13	R:R:L53	R:R:L57	8.3	No	No	0	5	5
14	R:R:H114	R:R:S54	4.18	Yes	No	0	5	5
15	R:R:N118	R:R:S54	4.47	No	No	0	4	5
16	R:R:H114	R:R:L57	12.86	Yes	No	0	5	5
17	R:R:E310	R:R:L57	6.63	No	No	0	5	5
18	R:R:H114	R:R:T58	4.11	Yes	No	0	5	5
19	R:R:S60	R:R:V314	4.85	No	No	0	5	5
20	R:R:L107	R:R:Y61	4.69	No	Yes	0	7	8
21	R:R:R110	R:R:Y61	12.35	Yes	Yes	0	7	8
22	R:R:V314	R:R:Y61	7.57	No	Yes	0	5	8
23	R:R:S317	R:R:Y61	5.09	No	Yes	0	7	8
24	R:R:F318	R:R:I64	7.54	No	No	0	5	7
25	R:R:F65	R:R:P108	7.22	Yes	No	0	7	9
26	R:R:C321	R:R:V67	5.12	No	No	0	7	6
27	R:R:I73	R:R:L69	4.28	No	No	0	3	6
28	R:R:G71	R:R:P324	4.06	No	No	0	8	9
29	R:R:D100	R:R:N72	6.73	Yes	No	0	9	9
30	R:R:N72	R:R:P324	11.4	No	No	0	9	9
31	R:R:F328	R:R:I74	5.02	No	No	0	6	5
32	R:R:I82	R:R:Y77	4.84	Yes	No	0	5	4
33	R:R:I82	R:R:V78	6.14	Yes	No	0	5	7
34	R:R:F79	R:R:Q90	5.86	No	Yes	0	6	7
35	R:R:F79	R:R:L93	4.87	No	Yes	2	6	8
36	R:R:F79	R:R:Y327	9.28	No	No	2	6	9
37	R:R:L80	R:R:R86	6.07	No	No	0	3	7
38	R:R:L80	R:R:L94	4.15	No	No	0	3	6
39	R:R:H83	R:R:I82	3.98	No	Yes	0	5	5
40	R:R:I337	R:R:I82	4.42	No	Yes	0	4	5
41	R:R:H83	R:R:Q90	12.36	No	Yes	0	5	7
42	R:R:Q90	R:R:R86	5.84	Yes	No	0	7	7
43	R:R:N87	R:R:Q90	9.24	No	Yes	0	8	7
44	R:R:D151	R:R:S88	8.83	No	No	2	8	6
45	R:R:K155	R:R:S88	4.59	No	No	2	8	6
46	R:R:D151	R:R:I89	8.4	No	Yes	2	8	7
47	R:R:I89	R:R:R152	6.26	Yes	No	0	7	9
48	R:R:I89	R:R:K155	4.36	Yes	No	2	7	8
49	R:R:I91	R:R:S171	7.74	No	No	0	6	7
50	R:R:I148	R:R:Y92	4.84	No	Yes	0	9	7
51	R:R:S171	R:R:Y92	12.72	No	Yes	0	7	7
52	R:R:V174	R:R:Y92	6.31	No	Yes	0	5	7
53	R:R:C175	R:R:Y92	4.03	No	Yes	0	6	7
54	R:R:L93	R:R:Y327	4.69	Yes	No	2	8	9
55	R:R:C175	R:R:N95	11.02	No	No	0	6	9
56	R:R:N95	R:R:W179	5.65	No	No	0	9	9
57	R:R:D100	R:R:V96	4.38	Yes	No	0	9	9
58	R:R:L144	R:R:V96	4.47	No	No	0	7	9
59	R:R:D100	R:R:S141	5.89	Yes	No	0	9	9
60	R:R:D100	R:R:S320	8.83	Yes	No	0	9	8
61	R:R:D100	R:R:D323	6.65	Yes	No	0	9	9
62	R:R:F105	R:R:L101	4.87	No	No	0	5	7
63	R:R:L102	R:R:N137	6.87	No	No	0	7	8
64	R:R:F134	R:R:L103	7.31	Yes	No	0	7	7
65	R:R:L103	R:R:N137	5.49	No	No	0	7	8
66	R:R:L103	R:R:S320	7.51	No	No	0	7	8
67	R:R:C106	R:R:L133	4.76	No	No	0	6	5
68	R:R:C106	R:R:F134	4.19	No	Yes	0	6	7
69	R:R:F109	R:R:V130	10.49	No	No	0	6	5
70	R:R:H114	R:R:R110	5.64	Yes	Yes	0	5	7
71	R:R:F205	R:R:R110	13.9	Yes	Yes	0	4	7
72	R:R:E310	R:R:R110	9.3	No	Yes	0	5	7
73	R:R:H114	R:R:Y113	7.62	Yes	Yes	0	5	5
74	R:R:N118	R:R:Y113	11.63	No	Yes	0	4	5
75	R:R:W120	R:R:Y113	5.79	Yes	Yes	0	9	5
76	R:R:M203	R:R:Y113	4.79	No	Yes	0	4	5
77	R:R:K119	R:R:Q117	4.07	No	No	0	4	3
78	R:R:L122	R:R:W120	14.81	Yes	Yes	0	7	9
79	R:R:C127	R:R:W120	16.98	No	Yes	3	9	9
80	R:R:C204	R:R:W120	9.14	No	Yes	3	9	9
81	R:R:L122	R:R:L126	4.15	Yes	No	0	7	5
82	R:R:C127	R:R:C204	7.28	No	No	3	9	9
83	R:R:C127	R:R:F205	4.19	No	Yes	3	9	4
84	R:R:K128	R:R:T193	6.01	No	No	4	8	5
85	R:R:H199	R:R:K128	5.24	No	No	4	3	8
86	R:R:K128	R:R:R208	6.19	No	Yes	0	8	5
87	R:R:F186	R:R:T132	6.49	Yes	No	0	7	5
88	R:R:M189	R:R:T132	7.53	No	No	1	4	5
89	R:R:L133	R:R:N137	5.49	No	No	0	5	8
90	R:R:F134	R:R:Y135	9.28	Yes	Yes	1	7	5
91	R:R:F134	R:R:L313	7.31	Yes	No	1	7	5
92	R:R:F134	R:R:S317	3.96	Yes	No	0	7	7
93	R:R:Y135	R:R:Y282	5.96	Yes	Yes	1	5	6
94	R:R:L313	R:R:Y135	7.03	No	Yes	1	5	5
95	R:R:F186	R:R:M136	7.46	Yes	No	0	7	5
96	R:R:M138	R:R:S316	6.13	No	No	0	7	7
97	R:R:L223	R:R:Y139	4.69	No	No	0	5	7
98	R:R:H283	R:R:Y139	11.98	No	No	0	8	7
99	R:R:I140	R:R:W179	7.05	No	No	0	7	9
100	R:R:F227	R:R:I142	6.28	No	No	0	8	8
101	R:R:F279	R:R:I142	8.79	Yes	No	0	8	8
102	R:R:I143	R:R:M226	4.37	No	No	0	5	5
103	R:R:L144	R:R:V178	5.96	No	No	0	7	7
104	R:R:F275	R:R:L145	4.87	Yes	No	0	9	8
105	R:R:F147	R:R:V174	5.24	No	No	0	5	5
106	R:R:I148	R:R:R152	7.52	No	No	0	9	9
107	R:R:I234	R:R:S149	7.74	No	No	0	8	9
108	R:R:S149	R:R:S237	4.89	No	No	6	9	6
109	R:R:S149	R:R:Y238	12.72	No	Yes	6	9	8
110	R:R:L150	R:R:L233	6.92	No	No	0	5	7
111	R:R:D151	R:R:K155	6.91	No	No	2	8	8
112	R:R:R152	R:R:Y238	8.23	No	Yes	0	9	8
113	R:R:N157	R:R:Y153	10.47	No	Yes	0	7	7
114	R:R:S237	R:R:Y153	3.82	No	Yes	0	6	7
115	R:R:K240	R:R:Y153	9.55	No	Yes	0	4	7
116	R:R:N157	R:R:N244	13.62	No	No	0	7	5
117	R:R:K169	R:R:Y173	10.75	No	No	0	4	2
118	R:R:E216	R:R:M189	9.47	Yes	No	0	3	4
119	R:R:K195	R:R:L192	7.05	No	No	0	4	4
120	R:R:H199	R:R:T193	6.85	No	No	4	3	5
121	R:R:E216	R:R:T193	7.06	Yes	No	0	3	5
122	R:R:K195	R:R:K196	4.31	No	No	0	4	3
123	R:R:N200	R:R:T202	8.77	No	No	0	5	4
124	R:R:M203	R:R:N200	4.21	No	No	0	4	5
125	R:R:H206	R:R:M203	9.19	No	No	0	5	4
126	R:R:C204	R:R:F205	4.19	No	Yes	3	9	4
127	R:R:H206	R:R:R208	7.9	No	Yes	0	5	5
128	R:R:D209	R:R:Y207	5.75	No	Yes	0	5	3
129	R:R:Y207	R:R:Y289	8.94	Yes	Yes	1	3	4
130	R:R:S292	R:R:Y207	7.63	No	Yes	0	3	3
131	R:R:Q293	R:R:Y207	4.51	No	Yes	1	4	3
132	R:R:K210	R:R:R208	4.95	Yes	Yes	0	3	5
133	R:R:D209	R:R:H211	6.3	No	No	0	5	4
134	R:R:E216	R:R:K210	14.85	Yes	Yes	0	3	3
135	R:R:K210	R:R:Q293	16.27	Yes	No	0	3	4
136	R:R:H211	R:R:N212	8.93	No	No	0	4	2
137	R:R:F219	R:R:L223	7.31	No	No	0	5	5
138	R:R:N220	R:R:R286	10.85	No	Yes	0	4	6
139	R:R:I290	R:R:N220	5.66	No	No	0	5	4
140	R:R:F221	R:R:V225	5.24	No	No	0	4	5
141	R:R:F221	R:R:F287	6.43	No	No	0	4	6
142	R:R:R286	R:R:V224	3.92	Yes	No	0	6	4
143	R:R:F287	R:R:V224	5.24	No	No	0	6	4
144	R:R:F227	R:R:W228	7.02	No	Yes	0	8	5
145	R:R:F227	R:R:H283	37.33	No	No	0	8	8
146	R:R:F231	R:R:W228	4.01	Yes	Yes	0	7	5
147	R:R:F287	R:R:W228	4.01	No	Yes	0	6	5
148	R:R:F231	R:R:I235	8.79	Yes	No	0	7	4
149	R:R:F231	R:R:F275	6.43	Yes	Yes	0	7	9
150	R:R:F231	R:R:T276	5.19	Yes	No	7	7	5
151	R:R:F231	R:R:V280	5.24	Yes	No	7	7	5
152	R:R:F275	R:R:I234	8.79	Yes	No	0	9	8
153	R:R:K240	R:R:L236	5.64	No	No	0	4	4
154	R:R:S237	R:R:Y238	3.82	No	Yes	6	6	8
155	R:R:V271	R:R:Y238	10.09	No	Yes	0	7	8
156	R:R:L272	R:R:Y238	5.86	No	Yes	0	7	8
157	R:R:I239	R:R:K243	5.82	No	No	0	3	4
158	R:R:F269	R:R:G242	4.52	No	No	0	4	4
159	R:R:N244	R:R:R247	10.85	No	No	0	5	5
160	R:R:I248	R:R:N244	4.25	No	No	0	6	5
161	R:R:R247	R:R:R251	4.26	No	No	0	5	4
162	R:R:I248	R:R:R252	10.02	No	No	0	6	4
163	R:R:I248	R:R:Y261	6.04	No	No	0	6	6
164	R:R:F255	R:R:R252	7.48	No	No	0	3	4
165	R:R:F255	R:R:P256	4.33	No	No	0	3	3
166	R:R:K260	R:R:Y261	14.33	No	No	0	5	6
167	R:R:K260	R:R:T264	4.5	No	No	0	5	7
168	R:R:R266	R:R:T263	5.17	No	No	0	6	7
169	R:R:I270	R:R:R266	5.01	No	No	0	5	6
170	R:R:M330	R:R:N267	18.23	No	No	0	6	7
171	R:R:F269	R:R:S268	3.96	No	No	0	4	7
172	R:R:M326	R:R:V271	10.65	No	No	0	7	7
173	R:R:F275	R:R:F279	13.93	Yes	Yes	0	9	8
174	R:R:T276	R:R:V280	6.35	No	No	7	5	5
175	R:R:C278	R:R:F279	4.19	No	Yes	5	7	8
176	R:R:C278	R:R:N319	9.45	No	No	5	7	9
177	R:R:F279	R:R:S316	3.96	Yes	No	0	8	7
178	R:R:F279	R:R:N319	12.08	Yes	No	5	8	9
179	R:R:H283	R:R:Y282	10.89	No	Yes	0	8	6
180	R:R:R286	R:R:Y282	12.35	Yes	Yes	1	6	6
181	R:R:N309	R:R:Y282	8.14	No	Yes	1	5	6
182	R:R:L313	R:R:Y282	7.03	No	Yes	1	5	6
183	R:R:F285	R:R:I288	8.79	Yes	No	0	5	5
184	R:R:F285	R:R:V305	5.24	Yes	Yes	0	5	4
185	R:R:F285	R:R:T308	14.27	Yes	No	0	5	5
186	R:R:F285	R:R:M312	4.98	Yes	No	0	5	6
187	R:R:R286	R:R:Y289	14.4	Yes	Yes	1	6	4
188	R:R:N309	R:R:R286	7.23	No	Yes	1	5	6
189	R:R:Q293	R:R:Y289	11.27	No	Yes	1	4	4
190	R:R:V305	R:R:Y289	5.05	Yes	Yes	0	4	4
191	R:R:N309	R:R:Y289	13.96	No	Yes	1	5	4
192	R:R:S292	R:R:V305	8.08	No	Yes	0	3	4
193	R:R:S297	R:R:W301	9.88	No	No	0	2	1
194	R:R:S298	R:R:Y300	5.09	No	No	0	5	2
195	R:R:C299	R:R:K302	8.08	No	No	0	7	4
196	R:R:I304	R:R:Y300	6.04	No	No	0	3	2
197	R:R:V305	R:R:W301	7.36	Yes	No	0	4	1
198	R:R:E303	R:R:K302	4.05	No	No	0	1	4
199	R:R:E310	R:R:H306	7.39	No	No	0	5	4
200	R:R:D323	R:R:N319	10.77	No	No	0	9	9
201	R:R:M326	R:R:M330	4.33	No	No	0	7	6
202	R:R:S331	R:R:Y327	10.17	No	No	0	8	9
203	R:R:I334	R:R:S331	4.64	No	No	0	8	8
204	R:R:F186	R:R:I190	3.77	Yes	No	0	7	5
205	R:R:F328	R:R:I334	3.77	No	No	0	6	8
206	R:R:A75	R:R:P324	3.74	No	No	0	8	9
207	R:R:F65	R:R:L107	3.65	Yes	No	0	7	7
208	R:R:F186	R:R:L183	3.65	Yes	No	0	7	4
209	R:R:G185	R:R:T188	3.64	No	No	0	4	8
210	R:R:I241	R:R:Y153	3.63	No	Yes	0	8	7
211	R:R:N267	R:R:R266	3.62	No	No	0	7	6
212	R:R:G68	R:R:I104	3.53	No	No	0	8	5
213	R:R:G146	R:R:I234	3.53	No	No	0	7	8
214	R:R:P281	R:R:V280	3.53	No	No	0	9	5
215	R:R:M112	R:R:W120	3.49	No	Yes	0	4	9
216	R:R:C321	R:R:I64	3.27	No	No	0	7	7
217	L:L:?1	R:R:I222	3.26	Yes	No	0	0	5
218	R:R:A99	R:R:I140	3.25	No	No	0	8	7
219	R:R:A182	R:R:I140	3.25	No	No	0	7	7
220	R:R:S201	R:R:V124	3.23	No	No	0	4	4
221	R:R:G198	R:R:H199	3.18	No	No	0	1	3
222	R:R:A97	R:R:L76	3.15	No	No	0	9	7
223	R:R:A265	R:R:L246	3.15	No	No	0	5	3
224	R:R:I241	R:R:S268	3.1	No	No	0	8	7
225	R:R:I190	R:R:V129	3.07	No	No	0	5	5
226	R:R:A213	R:R:E216	3.02	No	Yes	0	1	3
227	R:R:F109	R:R:W120	3.01	No	Yes	0	6	9
228	R:R:F205	R:R:G131	3.01	Yes	No	0	4	6
229	R:R:L329	R:R:V325	2.98	No	No	0	6	6
230	R:R:N333	R:R:S332	2.98	No	No	0	6	5
231	R:R:L122	R:R:T121	2.95	Yes	No	0	7	3
232	R:R:L245	R:R:T264	2.95	No	No	0	8	7
233	R:R:I111	R:R:I115	2.94	No	No	0	7	4
234	R:R:I143	R:R:I230	2.94	No	No	0	5	9
235	R:R:I156	R:R:I241	2.94	No	No	0	8	8
236	R:R:I270	R:R:I274	2.94	No	No	0	5	6
237	R:R:I273	R:R:I277	2.94	No	No	0	4	5
238	R:R:I311	R:R:L53	2.85	No	No	0	5	5
239	R:R:I64	R:R:L107	2.85	No	No	0	7	7
240	R:R:I104	R:R:L69	2.85	No	No	0	5	6
241	R:R:I98	R:R:L76	2.85	No	No	0	5	7
242	R:R:I89	R:R:L93	2.85	Yes	Yes	2	7	8
243	R:R:I148	R:R:L93	2.85	No	Yes	0	9	8
244	R:R:I190	R:R:L194	2.85	No	No	0	5	4
245	R:R:I274	R:R:L322	2.85	No	No	0	6	6
246	R:R:I277	R:R:L315	2.85	No	No	0	5	7
247	R:R:K307	R:R:L53	2.82	No	No	0	3	5
248	R:R:M112	R:R:N116	2.8	No	No	0	4	3
249	R:R:A284	R:R:W228	2.59	No	Yes	0	6	5
250	R:R:S249	R:R:Y261	2.54	No	No	0	3	6
251	R:R:F65	R:R:I104	2.51	Yes	No	0	7	5
252	R:R:F105	R:R:L69	2.44	No	No	0	5	6
253	R:R:F186	R:R:L187	2.44	Yes	No	0	7	4
254	R:R:I111	R:R:Y61	2.42	No	Yes	0	7	8
255	R:R:K302	R:R:Y207	2.39	No	Yes	0	4	3
256	R:R:I98	R:R:W179	2.35	No	No	0	5	9
257	R:R:G184	R:R:G185	2.11	No	No	0	3	4
258	R:R:G197	R:R:G198	2.11	No	No	0	1	1
259	R:R:A265	R:R:G242	1.95	No	No	0	5	4
260	R:R:A262	R:R:G259	1.95	No	No	0	5	4
261	R:R:G71	R:R:V70	1.84	No	No	0	8	4
262	R:R:G197	R:R:K196	1.74	No	No	0	1	3
263	R:R:G81	R:R:L80	1.71	No	No	0	4	3
264	R:R:G123	R:R:L122	1.71	No	Yes	0	7	7
265	R:R:A262	R:R:S249	1.71	No	No	0	5	3
266	R:R:C176	R:R:I172	1.64	No	No	0	4	4
267	R:R:L315	R:R:P281	1.64	No	No	0	7	9
268	R:R:N257	R:R:P256	1.63	No	No	0	4	3
269	R:R:S297	R:R:S298	1.63	No	No	0	2	5
270	R:R:S60	R:R:V56	1.62	No	No	0	5	5
271	R:R:C339	R:R:M338	1.62	No	No	0	4	5
272	R:R:A217	R:R:K210	1.61	No	Yes	0	4	3
273	R:R:S62	R:R:T58	1.6	No	No	0	6	5
274	R:R:V63	R:R:V67	1.6	No	No	0	5	6
275	R:R:A217	R:R:L294	1.58	No	No	0	4	1
276	R:R:I125	R:R:V124	1.54	No	No	0	1	4
277	R:R:I125	R:R:V129	1.54	No	No	0	1	5
278	R:R:F219	R:R:G185	1.51	No	No	0	5	4
279	R:R:I218	R:R:I222	1.47	No	No	0	5	5
280	R:R:I235	R:R:I239	1.47	No	No	0	4	3
281	R:R:I191	R:R:K195	1.45	No	No	0	4	4
282	R:R:Q170	R:R:T167	1.42	No	No	0	3	6
283	R:R:K250	R:R:L246	1.41	No	No	0	3	3
284	R:R:K119	R:R:N116	1.4	No	No	0	4	3
285	R:R:L294	R:R:N295	1.37	No	No	0	1	1
286	R:R:K169	R:R:Q170	1.36	No	No	0	4	3
287	R:R:F65	R:R:I66	1.26	Yes	No	0	7	5
288	R:R:K85	R:R:R84	1.24	No	No	0	6	5
289	R:R:F328	R:R:M338	1.24	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.765	10	1	0
2	L:L:S2	6.99	4	1	0
3	R:R:Y61	6.424	5	0	8
4	R:R:F65	3.66	4	0	7
5	R:R:I82	4.845	4	0	5
6	R:R:I89	5.4675	4	2	7
7	R:R:Q90	8.325	4	0	7
8	R:R:Y92	6.975	4	0	7
9	R:R:L93	3.815	4	2	8
10	R:R:D100	6.496	5	0	9
11	R:R:R110	10.2975	4	0	7
12	R:R:Y113	7.4575	4	0	5
13	R:R:H114	6.882	5	0	5
14	R:R:W120	8.87	6	3	9
15	R:R:L122	5.905	4	0	7
16	R:R:F134	6.41	5	1	7
17	R:R:Y135	7.762	5	1	5
18	R:R:Y153	6.8675	4	0	7
19	R:R:F186	4.762	5	0	7
20	R:R:F205	6.3225	4	3	4
21	R:R:Y207	5.844	5	1	3
22	R:R:R208	7.07	4	0	5
23	R:R:K210	9.42	4	0	3
24	R:R:E216	8.6	4	0	3
25	R:R:W228	4.4075	4	0	5
26	R:R:F231	5.932	5	7	7
27	R:R:Y238	8.144	5	6	8
28	R:R:F275	8.505	4	0	9
29	R:R:F279	8.59	5	5	8
30	R:R:Y282	8.874	5	1	6
31	R:R:F285	8.32	4	0	5
32	R:R:R286	8.78333	6	1	6
33	R:R:Y289	9.57333	6	1	4
34	R:R:V305	6.4325	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N220	10.2153	11.48	Yes	No	0	0	4
2	R:R:N220	R:R:R286	10.3662	10.85	No	Yes	0	4	6
3	L:L:?1	R:R:R208	34.6524	9.24	Yes	Yes	0	0	5
4	R:R:H206	R:R:R208	23.4351	7.9	No	Yes	0	5	5
5	R:R:H206	R:R:M203	22.3756	9.19	No	No	0	5	4
6	R:R:M203	R:R:Y113	18.871	4.79	No	Yes	0	4	5
7	L:L:?1	R:R:Y135	21.8033	8.91	Yes	Yes	1	0	5
8	R:R:F134	R:R:Y135	22.0263	9.28	Yes	Yes	1	7	5
9	R:R:F134	R:R:S317	43.9313	3.96	Yes	No	0	7	7
10	R:R:S317	R:R:Y61	42.9424	5.09	No	Yes	0	7	8
11	R:R:R110	R:R:Y61	21.8787	12.35	Yes	Yes	0	7	8
12	R:R:L107	R:R:Y61	18.1773	4.69	No	Yes	0	7	8
13	R:R:F65	R:R:L107	10.9943	3.65	Yes	No	0	7	7
14	R:R:F134	R:R:L103	12.0619	7.31	Yes	No	0	7	7
15	R:R:L103	R:R:S320	11.9258	7.51	No	No	0	7	8
16	R:R:D100	R:R:S320	11.8487	8.83	Yes	No	0	9	8
17	L:L:?1	L:L:S2	11.4633	12.56	Yes	Yes	1	0	0
18	L:L:S2	R:R:R286	10.4252	3.95	Yes	Yes	1	0	6
19	R:R:R286	R:R:V224	26.7806	3.92	Yes	No	0	6	4
20	R:R:F287	R:R:V224	26.4378	5.24	No	No	0	6	4
21	R:R:F287	R:R:W228	25.6539	4.01	No	Yes	0	6	5
22	R:R:F231	R:R:W228	61.7282	4.01	Yes	Yes	0	7	5
23	R:R:F231	R:R:F275	58.1859	6.43	Yes	Yes	0	7	9
24	R:R:F275	R:R:I234	100	8.79	Yes	No	0	9	8
25	R:R:I234	R:R:S149	98.3436	7.74	No	No	0	8	9
26	R:R:S149	R:R:Y238	70.1428	12.72	No	Yes	6	9	8
27	R:R:R152	R:R:Y238	63.1484	8.23	No	Yes	0	9	8
28	R:R:I89	R:R:R152	25.8015	6.26	Yes	No	0	7	9
29	R:R:I89	R:R:L93	20.7898	2.85	Yes	Yes	2	7	8
30	R:R:L93	R:R:Y327	14.2365	4.69	Yes	No	2	8	9
31	R:R:S331	R:R:Y327	12.49	10.17	No	No	0	8	9
32	R:R:I334	R:R:S331	10.3104	4.64	No	No	0	8	8
33	R:R:Y135	R:R:Y282	35.1329	5.96	Yes	Yes	1	5	6
34	R:R:H283	R:R:Y282	52.0475	10.89	No	Yes	0	8	6
35	R:R:F227	R:R:H283	72.1485	37.33	No	No	0	8	8
36	R:R:F227	R:R:W228	37.0894	7.02	No	Yes	0	8	5
37	L:L:?1	R:R:L223	19.5402	8.42	Yes	No	0	0	5
38	R:R:L223	R:R:Y139	20.2306	4.69	No	No	0	5	7
39	R:R:H283	R:R:Y139	20.6488	11.98	No	No	0	8	7
40	R:R:F227	R:R:I142	35.3592	6.28	No	No	0	8	8
41	R:R:F279	R:R:I142	35.1165	8.79	Yes	No	0	8	8
42	R:R:F275	R:R:F279	44.4331	13.93	Yes	Yes	0	9	8
43	R:R:I148	R:R:R152	36.6154	7.52	No	No	0	9	9
44	R:R:I148	R:R:L93	21.1424	2.85	No	Yes	0	9	8
45	R:R:F79	R:R:L93	25.3161	4.87	No	Yes	2	6	8
46	R:R:F79	R:R:Q90	23.6138	5.86	No	Yes	0	6	7
47	R:R:H83	R:R:Q90	10.604	12.36	No	Yes	0	5	7
48	R:R:I148	R:R:Y92	15.6108	4.84	No	Yes	0	9	7
49	R:R:C175	R:R:Y92	10.1087	4.03	No	Yes	0	6	7
50	R:R:D100	R:R:D323	11.2747	6.65	Yes	No	0	9	9
51	R:R:W120	R:R:Y113	15.7715	5.79	Yes	Yes	0	9	5
52	R:R:K128	R:R:R208	12.3374	6.19	No	Yes	0	8	5
53	L:L:?1	R:R:T132	15.0795	5.6	Yes	No	1	0	5
54	R:R:F186	R:R:T132	13.9872	6.49	Yes	No	0	7	5
55	R:R:S149	R:R:S237	27.3661	4.89	No	No	6	9	6
56	R:R:S237	R:R:Y153	29.557	3.82	No	Yes	0	6	7
57	R:R:N157	R:R:Y153	17.8658	10.47	No	Yes	0	7	7
58	R:R:N157	R:R:N244	16.7522	13.62	No	No	0	7	5
59	R:R:V271	R:R:Y238	10.1743	10.09	No	Yes	0	7	8
60	R:R:I248	R:R:N244	13.5691	4.25	No	No	0	6	5
61	R:R:D323	R:R:N319	11.2288	10.77	No	No	0	9	9
62	R:R:F279	R:R:N319	11.3026	12.08	Yes	No	5	8	9
63	R:R:L313	R:R:Y282	16.8818	7.03	No	Yes	1	5	6
64	R:R:F134	R:R:L313	16.5767	7.31	Yes	No	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T132	5.6	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y135	8.91	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L181	4.21	1	Yes	No	0	4	0	1
L:L:?1	R:R:M189	6.45	1	Yes	No	0	4	0	1
L:L:?1	R:R:R208	9.24	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N220	11.48	1	Yes	No	0	4	0	1
L:L:?1	R:R:L223	8.42	1	Yes	No	0	5	0	1
L:L:?1	R:R:M226	7.52	1	Yes	No	0	5	0	1
L:L:S2	R:R:Y135	7.63	1	Yes	Yes	0	5	0	1
L:L:S2	R:R:R286	3.95	1	Yes	Yes	0	6	0	1
L:L:S2	R:R:Y289	3.82	1	Yes	Yes	0	4	0	1
R:R:K128	R:R:R208	6.19	4	No	Yes	8	5	2	1
R:R:F186	R:R:T132	6.49	0	Yes	No	7	5	2	1
R:R:M189	R:R:T132	7.53	1	No	No	4	5	1	1
R:R:F134	R:R:Y135	9.28	1	Yes	Yes	7	5	2	1
R:R:F134	R:R:L313	7.31	1	Yes	No	7	5	2	2
R:R:Y135	R:R:Y282	5.96	1	Yes	Yes	5	6	1	2
R:R:L313	R:R:Y135	7.03	1	No	Yes	5	5	2	1
R:R:L223	R:R:Y139	4.69	0	No	No	5	7	1	2
R:R:I143	R:R:M226	4.37	0	No	No	5	5	2	1
R:R:E216	R:R:M189	9.47	0	Yes	No	3	4	2	1
R:R:H206	R:R:R208	7.9	0	No	Yes	5	5	2	1
R:R:Y207	R:R:Y289	8.94	1	Yes	Yes	3	4	2	1
R:R:Q293	R:R:Y207	4.51	1	No	Yes	4	3	2	2
R:R:K210	R:R:R208	4.95	0	Yes	Yes	3	5	2	1
R:R:E216	R:R:K210	14.85	0	Yes	Yes	3	3	2	2
R:R:K210	R:R:Q293	16.27	0	Yes	No	3	4	2	2
R:R:F219	R:R:L223	7.31	0	No	No	5	5	2	1
R:R:N220	R:R:R286	10.85	0	No	Yes	4	6	1	1
R:R:I290	R:R:N220	5.66	0	No	No	5	4	2	1
R:R:R286	R:R:V224	3.92	1	Yes	No	6	4	1	2
R:R:R286	R:R:Y282	12.35	1	Yes	Yes	6	6	1	2
R:R:N309	R:R:Y282	8.14	1	No	Yes	5	6	2	2
R:R:L313	R:R:Y282	7.03	1	No	Yes	5	6	2	2
R:R:R286	R:R:Y289	14.4	1	Yes	Yes	6	4	1	1
R:R:N309	R:R:R286	7.23	1	No	Yes	5	6	2	1
R:R:Q293	R:R:Y289	11.27	1	No	Yes	4	4	2	1
R:R:V305	R:R:Y289	5.05	0	Yes	Yes	4	4	2	1
R:R:N309	R:R:Y289	13.96	1	No	Yes	5	4	2	1
L:L:?1	R:R:I222	3.26	1	Yes	No	0	5	0	1
R:R:I218	R:R:I222	1.47	0	No	No	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IZ4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.82
Number of Linked Nodes	263
Number of Links	289
Number of Hubs	34
Number of Links mediated by Hubs	134
Number of Communities	7
Number of Nodes involved in Communities	36
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	87363
Length Of Smallest Path	3
Average Path Length	16.9152
Length of Longest Path	29
Minimum Path Strength	1.39
Average Path Strength	7.93213
Maximum Path Strength	24.655
Minimum Path Correlation	0.7
Average Path Correlation	0.928284
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	39.0801
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.0274
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TJR
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	TJR
Name	[(2~{R})-2-oxidanyl-3-phosphonooxy-propyl] octadecanoate
Synonyms
Identifier
Formula	C21 H43 O7 P
Molecular Weight	438.536
SMILES
PubChem	9547179
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	1
Total Bonds	71
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UPC5
Sequence	>8IZ4_nogp_Chain_R K L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H R K R N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q N K W T L G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N T T K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G G H N S T M C F H Y R D K H N A K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K R R S K F P N S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S Q L N V S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N I R K I M C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8SAI	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (S12)	-	Gi1/β1/γ2	3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8SAI (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (S12)	-		3.27	2023-10-04	doi.org/10.1073/pnas.2308435120
	8K4N	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 168719765	-	Gi1/β1/γ2	2.83	2023-10-25	To be published
	8K4N (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 168719765	-		2.83	2023-10-25	To be published
	8WRB	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (UBL)	-	Gi1/β1/γ2	2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8WRB (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (UBL)	-		2.91	2023-11-08	doi.org/10.1371/journal.pbio.3002387
	8XBE	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-Lysophosphatidylserine	-	Gi1/β1/γ1	3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBE (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-Lysophosphatidylserine	-		3.4	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBG	A	Orphan	Orphan	GPR34	Homo sapiens	S3E-Lysophosphatidylserine	-	-	3.43	2024-05-15	doi.org/10.1038/s41467-024-45046-z
	8XBH	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 162656636	-	Gi1/β1/γ2	2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBH (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 162656636	-		2.83	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8XBI	A	Orphan	Orphan	GPR34	Homo sapiens	PubChem 162656636	-	-	3.06	2023-12-27	doi.org/10.1038/s41467-024-45046-z
	8IYX	A	Orphan	Orphan	GPR34	Homo sapiens	YL-365	-	-	3.34	2024-03-20	doi.org/10.1073/pnas.2308435120
	8IZ4	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (TJR)	-	Gi1/β1/γ2	2.94	2024-04-10	To be published
	8IZ4 (No Gprot)	A	Orphan	Orphan	GPR34	Homo sapiens	Lysophosphatidylserine (TJR)	-		2.94	2024-04-10	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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You can also read or download a guide explaining the meaning of all files and numerical data.