Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 3.612586
2A:A:K53 5.095409
3A:A:M60 4.6275429
4A:A:V214 4.37486
5A:A:V217 3.338585
6A:A:F219 5.942588
7A:A:H220 8.645417
8A:A:M221 3.955408
9A:A:F222 9.0925417
10A:A:K233 4.026519
11A:A:W234 5.732519
12A:A:F238 5.078509
13A:A:F246 4.3075409
14A:A:V248 2.282507
15A:A:F273 5.1625409
16A:A:W277 7.89406
17A:A:W281 9.3125105
18A:A:I288 4.462529
19A:A:L289 4.5975409
20A:A:F290 4.382529
21A:A:I308 6.0025447
22A:A:Y311 8.42446
23A:A:F312 2.72548
24A:A:F315 9.176546
25A:A:Y318 4.252546
26A:A:P321 3.942545
27A:A:E330 5.435403
28A:A:Y339 5.49543
29A:A:F340 7.13833647
30A:A:R342 4.27667644
31A:A:F345 7.06408
32A:A:D354 2.78403
33A:A:Y358 7.625424
34A:A:Y360 4.69628
35A:A:H362 6.7875429
36A:A:F363 4.92545
37A:A:N371 6.8525429
38A:A:F376 4.07667688
39A:A:R385 7.814525
40A:A:H387 4.236158
41A:A:Y391 7.1565154
42B:B:V40 3.403336163
43B:B:M45 2.9054204
44B:B:R48 3.766597
45B:B:R49 2.655497
46B:B:H54 7.85667679
47B:B:W63 5.105607
48B:B:D76 5.09579
49B:B:K78 4.248578
50B:B:W82 8.325679
51B:B:Y85 9.835494
52B:B:N88 4.4425407
53B:B:K89 4.745609
54B:B:H91 3.9525405
55B:B:I93 3.31754117
56B:B:L95 3.1285118
57B:B:W99 7.07619
58B:B:M101 6.125419
59B:B:C114 2.814118
60B:B:L117 4.15419
61B:B:Y124 3.581437116
62B:B:R137 2.97754235
63B:B:H142 6.348519
64B:B:Y145 5.58143718
65B:B:F151 4.3045229
66B:B:S161 7.0875419
67B:B:D163 6.0425419
68B:B:W169 7.09143718
69B:B:D170 4.84459
70B:B:F180 6.802557
71B:B:H183 7.288559
72B:B:D186 5.606519
73B:B:F199 5.94459
74B:B:V200 4.52436
75B:B:C204 6.3325417
76B:B:D205 5.2825459
77B:B:K209 9.4725456
78B:B:W211 7.894558
79B:B:Q220 6.07437
80B:B:F222 5.396538
81B:B:H225 8.73639
82B:B:D228 6.596519
83B:B:I232 4.3225438
84B:B:F235 6.224297126
85B:B:P236 5.6554127
86B:B:F241 4.50143736
87B:B:T243 3.926538
88B:B:S245 6.2175439
89B:B:D247 6.44439
90B:B:R251 8.692538
91B:B:L252 2.675467
92B:B:F253 4.63636
93B:B:D258 5.486537
94B:B:M262 4.644564
95B:B:Y264 4.93667665
96B:B:I269 2.575404
97B:B:F278 4.015127
98B:B:R283 7.1085169
99B:B:L284 3.65254165
100B:B:Y289 5.10286767
101B:B:D290 5.444106
102B:B:N295 7.585466
103B:B:W297 4.24468
104B:B:H311 8.8825139
105B:B:R314 12.8854108
106B:B:V327 3.05254206
107B:B:W332 8.836676109
108B:B:D333 6.22254139
109B:B:L336 4.7625477
110B:B:K337 5.1045136
111B:B:W339 8.244139
112G:G:R27 4.46438
113G:G:Y40 7.20254126
114G:G:D48 5.5025409
115G:G:L51 3.2625166
116G:G:N59 5.825499
117G:G:P60 5.65499
118G:G:F61 4.1025898
119R:R:P40 5.2654183
120R:R:D44 4.795184
121R:R:V54 3.295407
122R:R:N58 6.1175409
123R:R:V61 2.275409
124R:R:F71 7.064508
125R:R:L78 3.155408
126R:R:D86 5.515409
127R:R:L93 2.2825406
128R:R:F97 5.57254185
129R:R:F101 5.1265184
130R:R:Y135 4.17408
131R:R:Y144 5.5145158
132R:R:W175 11.8154274
133R:R:P189 4.0075403
134R:R:H194 5.835277
135R:R:F202 5.0725148
136R:R:Y213 4.401676269
137R:R:H223 6.13833627
138R:R:I227 7.2975427
139R:R:F256 4.2145149
140R:R:W260 5.338336148
141R:R:Y266 5.618336173
142R:R:Y297 4.9225409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:W82 15.21474.56NoYes059
2B:B:L70 B:B:W63 15.54883.42NoYes057
3B:B:M61 B:B:W63 19.26184.65NoYes067
4B:B:C317 B:B:M61 19.57774.86NoNo076
5B:B:C317 B:B:S316 20.22653.44NoNo079
6B:B:S316 B:B:W332 20.5683.71NoYes099
7A:A:W281 B:B:W332 32.15563.75YesYes1059
8A:A:W281 B:B:D290 32.60733.35YesYes1056
9B:B:D290 B:B:T274 75.38654.34YesNo068
10B:B:S275 B:B:T274 75.37133.2NoNo088
11B:B:L318 B:B:S275 75.37556.01NoNo068
12B:B:L318 B:B:T329 75.3942.95NoNo068
13B:B:H311 B:B:T329 49.62265.48YesNo098
14B:B:D333 B:B:H311 24.77087.56YesYes1399
15B:B:D333 B:B:F335 24.62027.17YesNo094
16B:B:F335 B:B:R52 24.52915.34NoNo047
17B:B:R52 R:R:P69 79.71695.76NoNo075
18R:R:P69 R:R:T68 79.43.5NoNo057
19R:R:F71 R:R:T68 78.76436.49YesNo087
20R:R:F71 R:R:F76 76.399720.36YesNo089
21R:R:A73 R:R:F76 75.19012.77NoNo079
22R:R:A73 R:R:P74 74.89521.87NoNo075
23R:R:P74 R:R:T149 36.32813.5NoNo058
24R:R:T149 R:R:Y144 36.193.75NoYes088
25A:A:H387 R:R:Y144 22.24524.36YesYes1588
26A:A:H387 A:A:Y391 21.03682.18YesYes1584
27A:A:Y391 R:R:R134 31.93121.61YesNo049
28R:R:R134 R:R:Y213 10.86312.06NoYes099
29B:B:R314 B:B:W332 32.058417.99YesYes1089
30B:B:D290 B:B:R314 32.285510.72YesYes1068
31B:B:H311 B:B:K337 24.721110.48YesYes1396
32B:B:K337 B:B:T50 55.72663YesNo063
33B:B:R52 B:B:T50 55.52437.76NoNo073
34B:B:T329 B:B:W339 25.887.28NoYes089
35B:B:K337 B:B:W339 31.44285.8YesYes1369
36R:R:S137 R:R:Y144 14.99648.9NoYes1588
37A:A:Y391 R:R:S137 14.82365.09YesNo1548
38B:B:K57 B:B:W332 44.55417.4NoYes1099
39B:B:K57 B:B:Q75 44.30826.78NoNo099
40B:B:Q75 B:B:W99 44.06146.57NoYes099
41B:B:G162 B:B:Y145 24.61168.69NoYes198
42B:B:G162 B:B:S161 24.99983.71NoYes199
43B:B:G144 B:B:S161 21.14881.86NoYes089
44B:B:G144 B:B:N119 21.03983.39NoNo089
45A:A:G206 B:B:N119 20.82623.39NoNo089
46A:A:G206 A:A:S205 20.72041.86NoNo087
47A:A:F208 A:A:S205 20.6155.28NoNo057
48A:A:D223 A:A:F208 20.40523.58NoNo095
49A:A:D223 A:A:K53 20.30096.91NoYes099
50A:A:K53 A:A:L45 19.99848.46YesNo098
51A:A:L45 A:A:M221 11.75415.65NoYes088
52A:A:M221 A:A:M60 11.33414.33YesYes089
53A:A:F219 A:A:H41 10.05323.39YesYes886
54A:A:H41 A:A:I383 12.9682.65YesNo068
55A:A:H387 A:A:I383 13.27152.65YesNo088
56A:A:F238 B:B:W99 22.04357.02YesYes099
57A:A:R231 A:A:W234 28.99329NoYes099
58A:A:L272 A:A:R231 28.83537.29NoNo089
59A:A:F246 A:A:L272 28.34626.09YesNo098
60A:A:F246 A:A:V248 12.19372.62YesYes097
61A:A:F246 A:A:L289 15.85163.65YesYes099
62B:B:D290 B:B:G272 1003.35YesNo064
63B:B:C271 B:B:G272 99.83721.96NoNo054
64B:B:C271 B:B:Y289 99.46454.03NoYes657
65B:B:I273 B:B:Y289 94.04496.04NoYes067
66B:B:G244 B:B:I273 93.8651.76NoNo056
67B:B:G244 B:B:S245 93.6851.86NoYes059
68B:B:H225 B:B:S245 57.999412.55YesYes399
69B:B:H225 B:B:T243 34.44876.85YesYes398
70B:B:I232 B:B:T243 34.00054.56YesYes388
71B:B:I232 B:B:V200 33.12954.61YesYes386
72B:B:F234 B:B:V200 73.10587.87NoYes056
73B:B:A193 B:B:F234 70.90182.77NoNo045
74B:B:A193 B:B:D195 67.59614.63NoNo045
75B:B:D195 B:B:R197 66.49414.76NoNo055
76B:B:R197 B:B:T196 64.40973.88NoNo051
77B:B:L192 B:B:T196 63.30462.95NoNo051
78B:B:L152 B:B:L192 46.66224.15NoNo035
79B:B:L152 B:B:V158 43.34322.98NoNo035
80B:B:F199 B:B:V158 33.34882.62YesNo095
81B:B:F199 B:B:W211 27.798711.02YesYes598
82B:B:C218 B:B:W211 21.14477.84NoYes558
83B:B:C218 G:G:Q18 20.05763.05NoNo059
84G:G:K14 G:G:Q18 17.8358.14NoNo049
85G:G:E17 G:G:K14 16.72172.7NoNo064
86G:G:E17 G:G:K20 15.60832.7NoNo066
87B:B:I229 B:B:S245 34.62353.1NoYes379
88B:B:I229 B:B:T243 34.42023.04NoYes378
89B:B:F241 B:B:T243 34.44222.59YesYes368
90B:B:F241 B:B:V200 49.81592.62YesYes366
91B:B:F253 B:B:H225 22.74533.39YesYes369
92B:B:F241 B:B:F253 17.27658.57YesYes366
93B:B:L192 B:B:R150 15.56182.43NoNo056
94B:B:L190 B:B:R150 13.34062.43NoNo056
95B:B:L190 B:B:S160 11.12343NoNo056
96B:B:W297 B:B:Y289 10.19242.89YesYes687
97R:R:P74 R:R:T153 38.36146.99NoNo056
98R:R:L78 R:R:T153 38.03942.95YesNo086
99R:R:L157 R:R:L78 39.01992.77NoYes078
100R:R:L157 R:R:S81 38.77953NoNo079
101R:R:S126 R:R:S81 28.60914.89NoNo089
102R:R:L82 R:R:S126 27.81576.01NoNo098
103R:R:D86 R:R:L82 24.18762.71YesNo099
104R:R:D86 R:R:N58 14.412710.77YesYes099
105R:R:G51 R:R:V54 15.37591.84NoYes057
106R:R:G51 R:R:L93 13.81733.42NoYes056
107R:R:S81 R:R:W161 11.65486.18NoNo099
108R:R:R134 R:R:Y297 23.42374.12NoYes099
109R:R:L127 R:R:Y297 21.06684.69NoYes089
110R:R:L127 R:R:L82 11.83122.77NoNo089
111R:R:F256 R:R:L127 23.14452.44YesNo098
112R:R:A122 R:R:W161 11.12055.19NoNo079
113R:R:A122 R:R:A164 10.8531.79NoNo078
114R:R:A164 R:R:M118 10.31761.61NoNo084
115R:R:F202 R:R:F256 13.27948.57YesYes1489
116B:B:L117 B:B:W99 20.51984.56YesYes199
117A:A:F238 A:A:W234 20.96872YesYes099
118B:B:L117 B:B:Y145 15.83733.52YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8WW2
Class A
SubFamily Orphan
Type Orphan
SubType GPR3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.79
Date 2024-02-14
D.O.I. doi.org/10.1038/s41422-024-00932-5
Net Summary
Imin 1.87
Number of Linked Nodes 838
Number of Links 1003
Number of Hubs 142
Number of Links mediated by Hubs 534
Number of Communities 27
Number of Nodes involved in Communities 207
Number of Links involved in Communities 294
Path Summary
Number Of Nodes in MetaPath 119
Number Of Links MetaPath 118
Number of Shortest Paths 1730795
Length Of Smallest Path 3
Average Path Length 33.8331
Length of Longest Path 69
Minimum Path Strength 1.275
Average Path Strength 5.12368
Maximum Path Strength 18.975
Minimum Path Correlation 0.7
Average Path Correlation 0.982549
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 39.0317
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.511
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • metabolic process   • regulation of metabolic process   • multicellular organismal process   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of cellular process   • regulation of cellular component organization   • sexual reproduction   • regulation of reproductive process   • reproductive process   • meiotic cell cycle process   • cellular component organization   • meiotic nuclear division   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • cell cycle process   • regulation of meiotic cell cycle   • regulation of cell cycle process   • meiotic cell cycle   • organelle fission   • regulation of organelle organization   • regulation of meiotic nuclear division   • organelle organization   • nuclear division   • regulation of nuclear division   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • intracellular anatomical structure   • cytoplasm   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • mu-type opioid receptor binding   • opioid receptor binding   • beta-2 adrenergic receptor binding   • adrenergic receptor binding   • ionotropic glutamate receptor binding   • glutamate receptor binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • D1 dopamine receptor binding   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase activator activity   • insulin-like growth factor receptor binding   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • regulation of microtubule-based process   • regulation of spindle organization   • mitotic spindle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • response to wounding   • platelet activation   • developmental growth   • growth   • serotonin receptor signaling pathway   • adenylate cyclase-activating serotonin receptor signaling pathway   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • apical part of cell   • plasma membrane region   • apical plasma membrane
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8WW2_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAA THRLLLLGA GESGKSTIV 
KQMRTSGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSTN RLQEALNLF KSIWNNRWL RTISVILFL NKQDLLAEK 
VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF 
LRISTASGD GRHYCYPHF TCSVDTENI RRVFNDCRD IIQRMHLRQ 
YELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8WW2_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8WW2_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46089
Sequence
>8WW2_Chain_R
LPSPKAWDV VLCISGTLV SCENALVVA IIVGTPAFR APMFLLVGS 
LAVADLLAG LGLVLHFAA VFCIGSAEM SLVLVGVLA MAFTASIGS 
LLAITVDRY LSLYNALTY YSETTVTRT YVMLALVWG GALGLGLLP 
VLAWNCLDG LTTCGVVYP LSKNHLVVL AIAFFMVFG IMLQLYAQI 
CRIVCRHAQ QIALQRHTR KGIATLAVV LGAFAACWL PFTVYCLLG 
DAHSPPLYT YLTLLPATY NSMINPIIY AFRNQDVQK VLWAVCC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8H8JAOrphanOrphanGPR35Homo sapiensLodoxamideCachim(NtGi1L-G13)/β1/γ23.22023-02-08doi.org/10.1038/s41421-022-00499-8
8H8J (No Gprot) AOrphanOrphanGPR35Homo sapiensLodoxamideCa3.22023-02-08doi.org/10.1038/s41421-022-00499-8
8U8FAOrphanOrphanGPR3Homo sapiensPalmitic Acid-Gs/β1/γ23.492024-03-06doi.org/10.1021/acs.biochem.3c00647
8U8F (No Gprot) AOrphanOrphanGPR3Homo sapiensPalmitic Acid-3.492024-03-06doi.org/10.1021/acs.biochem.3c00647
8WW2AOrphanOrphanGPR3Homo sapiens--chim(NtGi1-Gs)/β1/γ22.792024-02-14doi.org/10.1038/s41422-024-00932-5
8WW2 (No Gprot) AOrphanOrphanGPR3Homo sapiens--2.792024-02-14doi.org/10.1038/s41422-024-00932-5
9LYBAOrphanOrphanGPR3Homo sapiens--Gs/β1/γ23.162025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYB (No Gprot) AOrphanOrphanGPR3Homo sapiens--3.162025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYCAOrphanOrphanGPR3Homo sapiens--Gs/β1/γ23.062025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYC (No Gprot) AOrphanOrphanGPR3Homo sapiens--3.062025-04-09doi.org/10.1016/j.celrep.2025.115478
9LYDAOrphanOrphanGPR3Homo sapiens---3.662025-04-09doi.org/10.1016/j.celrep.2025.115478
8X2KAOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-chim(NtGi1-Gs)/β1/γ23.032024-04-03doi.org/10.1038/s41422-023-00919-8
8X2K (No Gprot) AOrphanOrphanGPR3Homo sapiensOleic monoethanolamide-3.032024-04-03doi.org/10.1038/s41422-023-00919-8
8XOFAOrphanOrphanGPR30Homo sapiensLys05-chim(NtGi1-Gs-CtGq)/β1/γ22.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOF (No Gprot) AOrphanOrphanGPR30Homo sapiensLys05-2.62024-04-10doi.org/10.1038/s41422-024-00963-y
8XOGAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ22.92024-04-10doi.org/10.1038/s41422-024-00963-y
8XOG (No Gprot) AOrphanOrphanGPR30Homo sapiens--2.92024-04-10doi.org/10.1038/s41422-024-00963-y
8XOHAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOH (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOIAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOI (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.22024-04-10doi.org/10.1038/s41422-024-00963-y
8XOJAOrphanOrphanGPR30Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ23.12024-04-10doi.org/10.1038/s41422-024-00963-y
8XOJ (No Gprot) AOrphanOrphanGPR30Homo sapiens--3.12024-04-10doi.org/10.1038/s41422-024-00963-y
8XBEAOrphanOrphanGPR34Homo sapiensS3E-LysoPS-Gi1/β1/γ13.42024-05-15doi.org/10.1038/s41467-024-45046-z
8XBE (No Gprot) AOrphanOrphanGPR34Homo sapiensS3E-LysoPS-3.42024-05-15doi.org/10.1038/s41467-024-45046-z
8XBGAOrphanOrphanGPR34Homo sapiensS3E-LysoPS--3.432024-05-15doi.org/10.1038/s41467-024-45046-z
8SAIAOrphanOrphanGPR34Homo sapiens1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ23.272023-10-04doi.org/10.1073/pnas.2308435120
8SAI (No Gprot) AOrphanOrphanGPR34Homo sapiens1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-3.272023-10-04doi.org/10.1073/pnas.2308435120
8IYXAOrphanOrphanGPR34Homo sapiensYL-365--3.342024-03-20doi.org/10.1073/pnas.2308435120
8WRBAOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-Gi1/β1/γ22.912023-11-08doi.org/10.1371/journal.pbio.3002387
8WRB (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-2.912023-11-08doi.org/10.1371/journal.pbio.3002387
8XBHAOrphanOrphanGPR34Homo sapiensS3E-LysoPS-Gi1/β1/γ22.832023-12-27doi.org/10.1038/s41467-024-45046-z
8XBH (No Gprot) AOrphanOrphanGPR34Homo sapiensS3E-LysoPS-2.832023-12-27doi.org/10.1038/s41467-024-45046-z
8XBIAOrphanOrphanGPR34Homo sapiensS3E-LysoPS--3.062023-12-27doi.org/10.1038/s41467-024-45046-z
8K4NAOrphanOrphanGPR34Homo sapiensVF0-Gi1/β1/γ22.832023-10-25To be published
8K4N (No Gprot) AOrphanOrphanGPR34Homo sapiensVF0-2.832023-10-25To be published
8IZ4AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-Gi1/β1/γ22.942024-04-10To be published
8IZ4 (No Gprot) AOrphanOrphanGPR34Homo sapiensLysophosphatidylserine-2.942024-04-10To be published




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