Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 3.612596
2A:A:V214 4.37496
3A:A:V217 3.338595
4A:A:F219 5.942598
5A:A:H220 8.645417
6A:A:M221 3.955408
7A:A:F222 9.0925417
8A:A:K233 4.026519
9A:A:W234 5.732519
10A:A:F238 5.078509
11A:A:F246 4.3075409
12A:A:V248 2.282507
13A:A:F273 5.1625409
14A:A:W277 6.806506
15A:A:W281 9.3125115
16A:A:I285 2.24407
17A:A:I288 4.462539
18A:A:L289 4.5975409
19A:A:F290 4.382539
20A:A:Y311 6.0325446
21A:A:F312 2.78448
22A:A:F315 8.01546
23A:A:Y318 4.252546
24A:A:P321 3.942545
25A:A:E330 6.07403
26A:A:Y339 5.49543
27A:A:F340 7.13833647
28A:A:R342 4.27667644
29A:A:F345 7.06408
30A:A:Y358 5.72434
31A:A:Y360 4.69638
32A:A:H362 6.7875439
33A:A:F363 4.92545
34A:A:F376 4.07667698
35A:A:R385 7.814535
36A:A:H387 4.236168
37A:A:Y391 7.1565164
38B:B:I37 3.8554102
39B:B:V40 3.403336103
40B:B:M45 2.9054214
41B:B:R48 5.7725477
42B:B:R49 2.55577
43B:B:H54 7.85667689
44B:B:W63 5.105607
45B:B:D76 5.09589
46B:B:K78 4.248588
47B:B:W82 8.325689
48B:B:Y85 9.835474
49B:B:N88 4.4425407
50B:B:K89 4.745609
51B:B:H91 3.9525405
52B:B:I93 3.31754127
53B:B:L95 3.1285128
54B:B:W99 7.07619
55B:B:M101 6.125419
56B:B:Y111 6.714184
57B:B:C114 2.814128
58B:B:L117 4.15419
59B:B:Y124 3.581437126
60B:B:V133 2.87254124
61B:B:R137 2.97754245
62B:B:H142 6.348519
63B:B:Y145 5.58143718
64B:B:F151 4.3045239
65B:B:S161 7.0875419
66B:B:D163 6.0425419
67B:B:W169 7.09143718
68B:B:D170 4.84459
69B:B:F180 6.802557
70B:B:H183 7.288559
71B:B:D186 5.606519
72B:B:F199 5.94459
73B:B:V200 4.52426
74B:B:C204 6.3325417
75B:B:D205 5.2825459
76B:B:K209 9.4725456
77B:B:W211 7.894558
78B:B:Q220 6.07427
79B:B:F222 5.396528
80B:B:H225 8.73629
81B:B:D228 6.596519
82B:B:I232 4.3225428
83B:B:F235 6.224297136
84B:B:P236 5.6554137
85B:B:F241 4.50143726
86B:B:T243 3.926528
87B:B:S245 6.2175429
88B:B:D247 6.44429
89B:B:R251 8.692528
90B:B:L252 2.675467
91B:B:F253 4.63626
92B:B:D258 5.486527
93B:B:M262 4.644564
94B:B:Y264 4.93667665
95B:B:I269 2.575404
96B:B:F278 4.015137
97B:B:R283 7.1085109
98B:B:L284 3.65254105
99B:B:Y289 5.10286767
100B:B:D290 5.444116
101B:B:N295 7.585466
102B:B:W297 4.24468
103B:B:H311 8.8825149
104B:B:R314 12.8854118
105B:B:V327 3.05254216
106B:B:W332 8.836676119
107B:B:D333 6.22254149
108B:B:L336 4.7625487
109B:B:K337 5.1045146
110B:B:W339 6.7925149
111G:G:R27 4.46428
112G:G:Y40 7.20254136
113G:G:D48 5.5025409
114G:G:L51 3.2625106
115G:G:N59 6.4275479
116G:G:P60 5.65479
117G:G:F61 4.1025878
118R:R:P40 5.2654194
119R:R:D44 4.795198
120R:R:V54 3.295407
121R:R:E57 2.1725407
122R:R:N58 6.1175409
123R:R:V61 2.275409
124R:R:F71 7.064509
125R:R:L78 3.155408
126R:R:D86 5.515409
127R:R:L93 2.2825406
128R:R:F97 5.57254195
129R:R:F101 5.1265195
130R:R:Y135 4.17408
131R:R:Y144 5.5145168
132R:R:W175 12.0854288
133R:R:P189 4.0075402
134R:R:H194 5.835286
135R:R:F202 5.0725157
136R:R:Y213 4.401676279
137R:R:H223 6.13833638
138R:R:I227 6.3025437
139R:R:F256 4.2145158
140R:R:W260 5.338336158
141R:R:Y266 5.618336173
142R:R:S274 4.88254172
143R:R:Y297 4.9225409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:W82 14.85174.56NoYes059
2B:B:L70 B:B:W63 15.17423.42NoYes057
3B:B:M61 B:B:W63 18.74644.65NoYes067
4B:B:C317 B:B:M61 19.05154.86NoNo076
5B:B:C317 B:B:S316 19.67783.44NoNo079
6B:B:S316 B:B:W332 20.00753.71NoYes099
7A:A:W281 B:B:W332 31.6083.75YesYes1159
8A:A:W281 B:B:D290 32.04933.35YesYes1156
9B:B:D290 B:B:T274 74.43754.34YesNo068
10B:B:S275 B:B:T274 74.42023.2NoNo088
11B:B:L318 B:B:S275 74.4216.01NoNo068
12B:B:L318 B:B:T329 74.43192.95NoNo068
13B:B:H311 B:B:T329 48.97265.48YesNo098
14B:B:D333 B:B:H311 24.52267.56YesYes1499
15B:B:D333 B:B:F335 24.27667.17YesNo094
16B:B:F335 B:B:R52 24.18715.34NoNo047
17B:B:R52 R:R:P69 77.71595.76NoNo075
18R:R:P69 R:R:T68 77.4083.5NoNo056
19R:R:F71 R:R:T68 76.79026.49YesNo096
20R:R:F71 R:R:F76 74.494220.36YesNo099
21R:R:A73 R:R:F76 73.31812.77NoNo079
22R:R:A73 R:R:P74 73.03141.87NoNo076
23R:R:P74 R:R:T149 37.04643.5NoNo068
24R:R:T149 R:R:Y144 36.90223.75NoYes088
25A:A:H387 R:R:Y144 22.52464.36YesYes1688
26A:A:H387 A:A:Y391 20.58762.18YesYes1684
27A:A:Y391 R:R:R134 31.834921.61YesNo049
28R:R:R134 R:R:Y213 10.90722.06NoYes099
29B:B:R314 B:B:W332 31.515717.99YesYes1189
30B:B:D290 B:B:R314 31.737610.72YesYes1168
31B:B:H311 B:B:K337 24.339110.48YesYes1496
32B:B:K337 B:B:T50 54.05223YesNo063
33B:B:R52 B:B:T50 53.8567.76NoNo073
34B:B:T329 B:B:W339 25.57927.28NoYes089
35B:B:K337 B:B:W339 30.15445.8YesYes1469
36R:R:S137 R:R:Y144 15.32358.9NoYes1698
37A:A:Y391 R:R:S137 15.15055.09YesNo1649
38B:B:K57 B:B:W332 43.944917.4NoYes1199
39B:B:K57 B:B:Q75 43.7056.78NoNo099
40B:B:Q75 B:B:W99 43.4656.57NoYes099
41B:B:G162 B:B:Y145 23.71188.69NoYes198
42B:B:G162 B:B:S161 24.06893.71NoYes199
43B:B:G144 B:B:S161 20.15721.86NoYes089
44B:B:G144 B:B:N119 20.04643.39NoNo089
45A:A:G206 B:B:N119 19.82913.39NoNo089
46A:A:G206 A:A:S205 19.72141.86NoNo087
47A:A:F208 A:A:S205 19.61415.28NoNo057
48A:A:D223 A:A:F208 19.40053.58NoNo095
49A:A:D223 A:A:K53 19.29446.91NoNo099
50A:A:K53 A:A:L45 19.08978.46NoNo098
51A:A:L45 A:A:M221 11.09985.65NoYes088
52A:A:M221 A:A:M60 10.45124.33YesNo089
53A:A:H41 A:A:I383 12.14092.65YesNo068
54A:A:H387 A:A:I383 12.4442.65YesNo088
55A:A:F238 B:B:W99 21.17247.02YesYes099
56A:A:R231 A:A:W234 26.37059NoYes099
57A:A:L272 A:A:R231 26.21217.29NoNo089
58A:A:F246 A:A:L272 25.72336.09YesNo098
59A:A:F246 A:A:V248 10.89422.62YesYes097
60A:A:F246 A:A:L289 14.52543.65YesYes099
61B:B:D290 B:B:G272 1003.35YesNo064
62B:B:C271 B:B:G272 99.84841.96NoNo054
63B:B:C271 B:B:Y289 99.49754.03NoYes657
64B:B:I273 B:B:Y289 94.6516.04NoYes067
65B:B:G244 B:B:I273 94.48291.76NoNo056
66B:B:G244 B:B:S245 94.31471.86NoYes059
67B:B:H225 B:B:S245 58.29112.55YesYes299
68B:B:H225 B:B:T243 34.85416.85YesYes298
69B:B:I232 B:B:T243 34.42744.56YesYes288
70B:B:I232 B:B:V200 33.60044.61YesYes286
71B:B:F234 B:B:V200 74.78087.87NoYes056
72B:B:A193 B:B:F234 72.68622.77NoNo045
73B:B:A193 B:B:D195 69.54454.63NoNo045
74B:B:D195 B:B:R197 68.49724.76NoNo055
75B:B:R197 B:B:T196 66.52843.88NoNo051
76B:B:L192 B:B:T196 65.47812.95NoNo051
77B:B:L152 B:B:L192 49.65424.15NoNo035
78B:B:L152 B:B:V158 46.49962.98NoNo035
79B:B:F199 B:B:V158 36.99672.62YesNo095
80B:B:F199 B:B:W211 31.7211.02YesYes598
81B:B:C218 B:B:W211 25.39917.84NoYes558
82B:B:C218 G:G:Q18 24.37323.05NoNo059
83G:G:K14 G:G:Q18 22.26092.71NoNo049
84G:G:E17 G:G:K14 21.20274.05NoNo064
85G:G:E17 G:G:K20 20.14432.7NoNo066
86G:G:K20 G:G:V16 13.79013.04NoNo067
87B:B:L7 G:G:V16 11.67051.49NoNo087
88B:B:I229 B:B:S245 35.01683.1NoYes279
89B:B:I229 B:B:T243 34.82483.04NoYes278
90B:B:F241 B:B:T243 34.84742.59YesYes268
91B:B:F241 B:B:V200 50.52672.62YesYes266
92B:B:F253 B:B:H225 22.67653.39YesYes269
93B:B:F241 B:B:F253 17.48078.57YesYes266
94B:B:L192 B:B:R150 14.79922.43NoNo056
95B:B:L190 B:B:R150 12.68692.43NoNo056
96B:B:L190 B:B:S160 10.57963NoNo056
97R:R:P74 R:R:T153 35.78286.99NoNo066
98R:R:L78 R:R:T153 35.46922.95YesNo086
99R:R:L157 R:R:L78 36.34252.77NoYes078
100R:R:L157 R:R:S81 36.10193NoNo079
101R:R:S126 R:R:S81 25.8044.89NoNo089
102R:R:L82 R:R:S126 25.0036.01NoNo098
103R:R:D86 R:R:L82 20.12682.71YesNo099
104R:R:D86 R:R:N58 12.482210.77YesYes099
105R:R:G51 R:R:V54 11.13971.84NoYes067
106R:R:S81 R:R:W161 11.846.18NoNo099
107R:R:R134 R:R:Y297 23.38484.12NoYes099
108R:R:L127 R:R:Y297 21.03654.69NoYes089
109R:R:L127 R:R:L82 11.44112.77NoNo089
110R:R:F256 R:R:L127 24.20572.44YesNo088
111R:R:A122 R:R:W161 11.30955.19NoNo079
112R:R:A122 R:R:A164 11.0441.79NoNo078
113R:R:A164 R:R:M118 10.51241.61NoNo085
114R:R:F202 R:R:F256 14.39788.57YesYes1578
115B:B:L117 B:B:W99 20.8974.56YesYes199
116A:A:F238 A:A:W234 19.63482YesYes099
117B:B:L117 B:B:Y145 15.91023.52YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8WW2
Class A
SubFamily Orphan
Type A orphans
SubType GPR3
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.79
Date 2024-02-14
D.O.I. 10.1038/s41422-024-00932-5
Net Summary
Imin 1.87
Number of Linked Nodes 836
Number of Links 1002
Number of Hubs 143
Number of Links mediated by Hubs 538
Number of Communities 28
Number of Nodes involved in Communities 212
Number of Links involved in Communities 300
Path Summary
Number Of Nodes in MetaPath 118
Number Of Links MetaPath 117
Number of Shortest Paths 1747335
Length Of Smallest Path 3
Average Path Length 34.2437
Length of Longest Path 73
Minimum Path Strength 1.275
Average Path Strength 5.09354
Maximum Path Strength 18.975
Minimum Path Correlation 0.7
Average Path Correlation 0.982528
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 38.8905
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.8379
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8WW2_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAA THRLLLLGA GESGKSTIV 
KQMRTSGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSTN RLQEALNLF KSIWNNRWL RTISVILFL NKQDLLAEK 
VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF 
LRISTASGD GRHYCYPHF TCSVDTENI RRVFNDCRD IIQRMHLRQ 
YELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8WW2_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8WW2_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46089
Sequence
>8WW2_Chain_R
LPSPKAWDV VLCISGTLV SCENALVVA IIVGTPAFR APMFLLVGS 
LAVADLLAG LGLVLHFAA VFCIGSAEM SLVLVGVLA MAFTASIGS 
LLAITVDRY LSLYNALTY YSETTVTRT YVMLALVWG GALGLGLLP 
VLAWNCLDG LTTCGVVYP LSKNHLVVL AIAFFMVFG IMLQLYAQI 
CRIVCRHAQ QIALQRHTR KGIATLAVV LGAFAACWL PFTVYCLLG 
DAHSPPLYT YLTLLPATY NSMINPIIY AFRNQDVQK VLWAVCC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8U8FAOrphanA orphansGPR3Homo sapiensPML-Gs/&β;1/&γ;23.492024-03-0610.1021/acs.biochem.3c00647
8WW2AOrphanA orphansGPR3Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;22.792024-02-1410.1038/s41422-024-00932-5
8X2KAOrphanA orphansGPR3Homo sapiens5YM-chim(NtGi1-Gs)/&β;1/&γ;23.032024-04-03To be published
8IYXAOrphanA orphansGPR34Homo sapiensYL-365--3.342024-03-2010.1073/pnas.2308435120
8IZ4AOrphanA orphansGPR34Homo sapiensLysophosphatidylserine-Gi1/&β;1/&γ;22.942024-04-10To be published
8K4NAOrphanA orphansGPR34Homo sapiensVF0-Gi1/&β;1/&γ;22.832023-10-25To be published
8SAIAOrphanA orphansGPR34Homo sapiens1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;23.272023-10-0410.1073/pnas.2308435120
8WRBAOrphanA orphansGPR34Homo sapiensLysophosphatidylserine-Gi1/&β;1/&γ;22.912023-11-0810.1371/journal.pbio.3002387
8XBHAOrphanA orphansGPR34Homo sapiensS3E-LysoPS-Gi1/&β;1/&γ;22.832023-12-27To be published
8XBIAOrphanA orphansGPR34Homo sapiensS3E-LysoPS--3.062023-12-27To be published
8H8JAOrphanA orphansGPR35Homo sapiensLodoxamideCachim(NtGi1L-G13)/&β;1/&γ;23.22023-02-0810.1038/s41421-022-00499-8




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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