psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L137	6.26	Yes	No	0	0	6
2	L:L:?1	R:R:E275	8.98	Yes	Yes	0	0	6
3	L:L:?1	R:R:H282	3.63	Yes	No	0	0	4
4	L:L:?1	R:R:H300	5.81	Yes	No	0	0	4
5	R:R:E51	R:R:H52	13.54	No	No	0	2	4
6	R:R:L59	R:R:Y55	12.89	No	No	0	5	1
7	R:R:F60	R:R:L64	12.18	No	No	0	5	6
8	R:R:S62	R:R:V116	6.46	No	No	0	6	7
9	R:R:F68	R:R:L64	4.87	No	No	0	5	6
10	R:R:L69	R:R:Y65	8.21	Yes	Yes	2	7	7
11	R:R:F70	R:R:Y65	3.09	Yes	Yes	0	7	7
12	R:R:S112	R:R:Y65	10.17	No	Yes	2	8	7
13	R:R:F314	R:R:Y65	4.13	No	Yes	2	6	7
14	R:R:C318	R:R:Y65	4.03	Yes	Yes	2	8	7
15	R:R:F68	R:R:I67	10.05	No	No	0	5	4
16	R:R:L69	R:R:S315	4.5	Yes	No	0	7	5
17	R:R:C318	R:R:L69	3.17	Yes	Yes	2	8	7
18	R:R:L319	R:R:L69	4.15	No	Yes	0	6	7
19	R:R:F70	R:R:P71	4.33	Yes	No	0	7	5
20	R:R:F70	R:R:F74	7.5	Yes	No	0	7	6
21	R:R:F70	R:R:V109	3.93	Yes	No	0	7	6
22	R:R:F70	R:R:L113	12.18	Yes	No	0	7	9
23	R:R:I72	R:R:L322	4.28	No	No	0	5	6
24	R:R:C318	R:R:G73	3.92	Yes	No	0	8	8
25	R:R:F74	R:R:I78	7.54	No	No	0	6	4
26	R:R:L79	R:R:V75	2.98	No	No	0	6	4
27	R:R:F326	R:R:G76	4.52	No	No	0	7	7
28	R:R:D105	R:R:N77	6.73	Yes	No	0	9	9
29	R:R:L106	R:R:N77	4.12	No	No	0	7	9
30	R:R:N77	R:R:P321	13.03	No	No	0	9	9
31	R:R:A102	R:R:I80	3.25	No	Yes	0	9	9
32	R:R:I80	R:R:S325	7.74	Yes	No	5	9	7
33	R:R:F331	R:R:I80	6.28	No	Yes	5	9	9
34	R:R:I99	R:R:L81	4.28	No	No	0	6	7
35	R:R:L81	R:R:V103	4.47	No	No	0	7	5
36	R:R:N84	R:R:V83	2.96	No	Yes	0	7	8
37	R:R:K334	R:R:V83	4.55	No	Yes	0	5	8
38	R:R:V83	R:R:Y338	3.79	Yes	Yes	0	8	5
39	R:R:I99	R:R:N84	8.5	No	No	0	6	7
40	R:R:S86	R:R:Y338	5.09	No	Yes	0	4	5
41	R:R:F87	R:R:K90	8.69	Yes	No	0	5	6
42	R:R:F87	R:R:K334	3.72	Yes	No	0	5	5
43	R:R:F87	R:R:Y338	5.16	Yes	Yes	0	5	5
44	R:R:R175	R:R:R88	5.33	No	No	0	4	4
45	R:R:D95	R:R:M91	8.32	No	No	0	7	6
46	R:R:L96	R:R:M91	4.24	No	No	0	6	6
47	R:R:P94	R:R:T92	3.5	No	No	0	8	7
48	R:R:D95	R:R:T92	10.12	No	No	0	7	7
49	R:R:I93	R:R:P94	3.39	Yes	No	0	6	8
50	R:R:I93	R:R:Y97	4.84	Yes	Yes	0	6	7
51	R:R:I93	R:R:R169	11.27	Yes	No	0	6	7
52	R:R:A174	R:R:I93	4.87	No	Yes	0	7	6
53	R:R:D95	R:R:K334	4.15	No	No	0	7	5
54	R:R:L96	R:R:R175	3.64	No	No	0	6	4
55	R:R:W150	R:R:Y97	13.5	Yes	Yes	6	7	7
56	R:R:D154	R:R:Y97	9.2	No	Yes	0	8	7
57	R:R:S177	R:R:Y97	3.82	No	Yes	6	5	7
58	R:R:F98	R:R:M151	6.22	No	No	0	8	9
59	R:R:F98	R:R:Y324	4.13	No	Yes	0	8	9
60	R:R:F147	R:R:N100	15.71	Yes	No	3	8	9
61	R:R:C178	R:R:N100	6.3	No	No	3	7	9
62	R:R:N100	R:R:W182	4.52	No	No	3	9	9
63	R:R:D105	R:R:L101	8.14	Yes	No	1	9	9
64	R:R:L101	R:R:S144	3	No	No	1	9	9
65	R:R:L101	R:R:L148	6.92	No	No	1	9	8
66	R:R:D105	R:R:S144	4.42	Yes	No	1	9	9
67	R:R:D105	R:R:S317	10.31	Yes	No	0	9	8
68	R:R:D105	R:R:N320	9.42	Yes	Yes	1	9	9
69	R:R:F136	R:R:I107	5.02	No	No	7	4	7
70	R:R:I107	R:R:N140	14.16	No	Yes	7	7	8
71	R:R:L108	R:R:S317	6.01	No	No	0	7	8
72	R:R:C318	R:R:V109	3.42	Yes	No	0	8	6
73	R:R:D111	R:R:L137	13.57	No	No	0	7	6
74	R:R:F314	R:R:S112	15.85	No	No	2	6	8
75	R:R:E115	R:R:H120	17.23	No	No	0	6	3
76	R:R:E115	R:R:F314	4.66	No	No	0	6	6
77	R:R:F117	R:R:V116	9.18	No	No	0	3	7
78	R:R:E121	R:R:H120	9.85	No	No	0	4	3
79	R:R:E121	R:R:Y124	5.61	No	No	0	4	3
80	R:R:R122	R:R:Y123	8.23	No	No	0	4	8
81	R:R:L129	R:R:Y123	3.52	No	No	0	6	8
82	R:R:D125	R:R:V128	4.38	No	No	0	7	3
83	R:R:D125	R:R:L129	4.07	No	No	0	7	6
84	R:R:C130	R:R:I126	3.27	No	No	0	9	8
85	R:R:F193	R:R:L135	4.87	Yes	No	0	4	6
86	R:R:F136	R:R:N140	12.08	No	Yes	7	4	8
87	R:R:Q138	R:R:T189	5.67	No	Yes	0	5	7
88	R:R:E218	R:R:Q138	15.29	No	No	0	5	5
89	R:R:N140	R:R:V139	2.96	Yes	No	0	8	5
90	R:R:T189	R:R:V139	6.35	Yes	No	0	7	5
91	R:R:M141	R:R:W272	5.82	No	Yes	0	7	9
92	R:R:F146	R:R:Y142	9.28	No	No	0	6	7
93	R:R:T189	R:R:Y142	3.75	Yes	No	0	7	7
94	R:R:L217	R:R:Y142	3.52	No	No	0	4	7
95	R:R:S143	R:R:W182	14.83	No	No	0	7	9
96	R:R:S143	R:R:S185	6.52	No	No	0	7	7
97	R:R:P226	R:R:V145	3.53	Yes	No	0	9	8
98	R:R:V145	R:R:W272	3.68	No	Yes	0	8	9
99	R:R:F146	R:R:L221	6.09	No	No	0	6	4
100	R:R:C178	R:R:F147	4.19	No	Yes	3	7	8
101	R:R:F147	R:R:I181	11.3	Yes	No	0	8	7
102	R:R:F147	R:R:W182	9.02	Yes	No	3	8	9
103	R:R:L148	R:R:N320	6.87	No	Yes	1	8	9
104	R:R:L148	R:R:Y324	7.03	No	Yes	1	8	9
105	R:R:P226	R:R:T149	3.5	Yes	No	0	9	8
106	R:R:I229	R:R:T149	6.08	No	No	0	7	8
107	R:R:I230	R:R:T149	6.08	Yes	No	0	8	8
108	R:R:F153	R:R:W150	5.01	No	Yes	0	6	7
109	R:R:S177	R:R:W150	8.65	No	Yes	6	5	7
110	R:R:I181	R:R:W150	4.7	No	Yes	0	7	7
111	R:R:I230	R:R:S152	4.64	Yes	No	0	8	9
112	R:R:C233	R:R:S152	5.16	No	No	0	8	9
113	R:R:S152	R:R:Y234	5.09	No	Yes	0	9	8
114	R:R:F153	R:R:I157	7.54	No	No	0	6	5
115	R:R:D154	R:R:R169	13.1	No	No	0	8	7
116	R:R:R155	R:R:Y234	8.23	No	Yes	0	9	8
117	R:R:R155	R:R:Y324	6.17	No	Yes	0	9	9
118	R:R:I157	R:R:Y156	3.63	No	Yes	0	5	8
119	R:R:A160	R:R:Y156	4	No	Yes	0	7	8
120	R:R:R161	R:R:Y156	5.14	No	Yes	0	6	8
121	R:R:L236	R:R:Y156	9.38	No	Yes	0	3	8
122	R:R:I237	R:R:Y156	3.63	No	Yes	0	8	8
123	R:R:C165	R:R:I157	3.27	No	No	0	6	5
124	R:R:A158	R:R:R169	6.91	No	No	0	8	7
125	R:R:I237	R:R:L159	4.28	No	No	0	8	8
126	R:R:C165	R:R:R161	4.18	No	No	0	6	6
127	R:R:H173	R:R:T170	9.58	No	No	0	3	6
128	R:R:K171	R:R:R175	4.95	No	No	0	4	4
129	R:R:H172	R:R:H173	7.17	No	No	0	3	3
130	R:R:L190	R:R:V186	2.98	No	No	0	4	4
131	R:R:P192	R:R:V191	3.53	No	No	0	4	7
132	R:R:L217	R:R:P192	4.93	No	No	0	4	4
133	R:R:V196	R:R:V211	12.83	No	No	8	5	4
134	R:R:V196	R:R:V214	3.21	No	No	8	5	4
135	R:R:V211	R:R:V214	4.81	No	No	8	4	4
136	R:R:E218	R:R:V214	5.7	No	No	0	5	4
137	R:R:L283	R:R:Q215	6.65	No	No	0	5	4
138	R:R:L283	R:R:W216	9.11	No	No	0	5	4
139	R:R:L217	R:R:L221	4.15	No	No	0	4	4
140	R:R:N276	R:R:V219	4.43	No	Yes	0	8	5
141	R:R:I279	R:R:V219	4.61	No	Yes	0	5	5
142	R:R:S280	R:R:V219	4.85	No	Yes	0	5	5
143	R:R:G222	R:R:P226	4.06	No	Yes	0	5	9
144	R:R:F223	R:R:L273	3.65	No	No	0	9	5
145	R:R:F223	R:R:N276	16.92	No	No	0	9	8
146	R:R:P226	R:R:V225	3.53	Yes	No	0	9	5
147	R:R:I229	R:R:V225	3.07	No	No	0	7	5
148	R:R:F227	R:R:F268	4.29	No	No	0	6	9
149	R:R:F227	R:R:F269	11.79	No	No	0	6	5
150	R:R:G231	R:R:I230	3.53	No	Yes	0	4	8
151	R:R:F268	R:R:I230	7.54	No	Yes	0	9	8
152	R:R:L232	R:R:L236	4.15	No	No	0	4	3
153	R:R:I261	R:R:Y234	9.67	No	Yes	0	7	8
154	R:R:V265	R:R:Y234	5.05	No	Yes	0	7	8
155	R:R:I237	R:R:I261	2.94	No	No	0	8	7
156	R:R:L258	R:R:V238	4.47	No	No	0	6	5
157	R:R:I261	R:R:V238	4.61	No	No	0	7	5
158	R:R:R239	R:R:R243	13.86	No	No	0	3	3
159	R:R:L241	R:R:L258	5.54	No	No	0	8	6
160	R:R:L258	R:R:V242	2.98	No	No	0	6	4
161	R:R:H245	R:R:R251	14.67	No	No	0	4	3
162	R:R:H245	R:R:Q255	7.42	No	No	0	4	5
163	R:R:G249	R:R:R254	6	No	No	0	3	6
164	R:R:L250	R:R:P252	4.93	No	No	0	3	3
165	R:R:L250	R:R:R253	3.64	No	No	0	3	5
166	R:R:E329	R:R:R253	5.82	No	No	0	4	5
167	R:R:K256	R:R:R259	3.71	No	No	0	7	5
168	R:R:G328	R:R:M260	3.49	No	No	0	8	8
169	R:R:I323	R:R:V264	6.14	No	No	1	7	8
170	R:R:V264	R:R:Y324	12.62	No	Yes	1	8	9
171	R:R:L319	R:R:V267	4.47	No	No	0	6	7
172	R:R:F268	R:R:W272	9.02	No	Yes	0	9	9
173	R:R:F269	R:R:L273	7.31	No	No	0	5	5
174	R:R:C271	R:R:S315	5.16	No	No	0	9	5
175	R:R:C271	R:R:N316	6.3	No	No	0	9	9
176	R:R:E275	R:R:W272	3.27	Yes	Yes	4	6	9
177	R:R:A313	R:R:W272	3.89	No	Yes	4	8	9
178	R:R:N316	R:R:W272	15.82	No	Yes	0	9	9
179	R:R:L273	R:R:V277	2.98	No	No	0	5	5
180	R:R:P274	R:R:V309	3.53	No	Yes	0	9	7
181	R:R:A313	R:R:E275	3.02	No	Yes	4	8	6
182	R:R:F278	R:R:H282	7.92	No	No	0	5	4
183	R:R:F278	R:R:T305	3.89	No	No	0	5	5
184	R:R:H282	R:R:H302	4.78	No	No	0	4	4
185	R:R:A301	R:R:H302	7.32	No	No	0	5	4
186	R:R:H307	R:R:L311	11.57	No	No	0	4	5
187	R:R:N310	R:R:V309	2.96	No	Yes	0	5	7
188	R:R:N316	R:R:N320	9.54	No	Yes	0	9	9
189	R:R:N320	R:R:Y324	5.81	Yes	Yes	1	9	9
190	R:R:L322	R:R:L327	4.15	No	No	0	6	6
191	R:R:I323	R:R:Y324	7.25	No	Yes	1	7	9
192	R:R:F331	R:R:S325	14.53	No	No	5	9	7
193	R:R:F326	R:R:F331	5.36	No	No	0	7	9
194	R:R:D333	R:R:E329	6.5	No	No	0	4	4
195	R:R:I339	R:R:L335	4.28	No	No	0	5	6
196	R:R:K342	R:R:Y338	15.53	No	Yes	0	5	5
197	R:R:K342	R:R:Q341	4.07	No	No	0	5	2
198	R:R:P252	R:R:R251	2.88	No	No	0	3	3
199	R:R:K256	R:R:M260	2.88	No	No	0	7	8
200	R:R:I57	R:R:L61	2.85	No	No	0	4	5
201	R:R:I57	R:R:L304	2.85	No	No	0	4	2
202	R:R:E213	R:R:V196	2.85	No	No	0	3	5
203	R:R:E275	R:R:V309	2.85	Yes	Yes	0	6	7
204	R:R:I279	R:R:L283	2.85	No	No	0	5	5
205	R:R:I308	R:R:L304	2.85	No	No	0	5	2
206	R:R:I80	R:R:N84	2.83	Yes	No	0	9	7
207	R:R:L137	R:R:M133	2.83	No	No	0	6	5
208	R:R:D111	R:R:I114	2.8	No	No	0	7	6
209	R:R:H307	R:R:S62	2.79	No	No	0	4	6
210	R:R:A244	R:R:R254	2.77	No	No	0	5	6
211	R:R:L108	R:R:N140	2.75	No	Yes	0	7	8
212	R:R:E89	R:R:K90	2.7	No	No	0	5	6
213	R:R:L304	R:R:Q54	2.66	No	No	0	2	4
214	R:R:F193	R:R:T131	2.59	Yes	No	0	4	7
215	R:R:E51	R:R:Q54	2.55	No	No	0	2	4
216	R:R:H120	R:R:N118	2.55	No	No	0	3	5
217	R:R:V116	R:R:Y65	2.52	No	Yes	0	7	7
218	R:R:K256	R:R:R332	2.48	No	No	0	7	8
219	R:R:F87	R:R:L337	2.44	Yes	No	0	5	4
220	R:R:F117	R:R:L119	2.44	No	No	0	3	5
221	R:R:T220	R:R:W216	2.43	No	No	0	5	4
222	R:R:E329	R:R:R332	2.33	No	No	0	4	8
223	R:R:F193	R:R:H197	2.26	Yes	No	0	4	5
224	R:R:H247	R:R:R246	2.26	No	No	0	3	4
225	R:R:H247	R:R:R248	2.26	No	No	0	3	2
226	R:R:E51	R:R:Y55	2.24	No	No	0	2	1
227	R:R:F168	R:R:W150	2	No	Yes	0	1	7
228	R:R:C178	R:R:G179	1.96	No	No	0	7	4
229	R:R:A312	R:R:P274	1.87	No	No	0	7	9
230	R:R:G231	R:R:S235	1.86	No	No	0	4	3
231	R:R:G76	R:R:V75	1.84	No	No	0	7	4
232	R:R:G306	R:R:V309	1.84	No	Yes	0	4	7
233	R:R:G73	R:R:I72	1.76	No	No	0	8	5
234	R:R:A104	R:R:S143	1.71	No	No	0	8	7
235	R:R:A104	R:R:S144	1.71	No	No	0	8	9
236	R:R:C271	R:R:V270	1.71	No	No	0	9	6
237	R:R:A127	R:R:V128	1.7	No	No	0	3	3
238	R:R:A160	R:R:V240	1.7	No	No	0	7	5
239	R:R:C63	R:R:I67	1.64	No	No	0	4	4
240	R:R:S185	R:R:V186	1.62	No	No	0	7	4
241	R:R:A162	R:R:M163	1.61	No	No	0	8	5
242	R:R:V82	R:R:V83	1.6	No	Yes	0	3	8
243	R:R:V277	R:R:V281	1.6	No	No	0	5	4
244	R:R:G58	R:R:H307	1.59	No	No	0	3	4
245	R:R:P303	R:R:Q54	1.58	No	No	0	3	4
246	R:R:A188	R:R:L221	1.58	No	No	0	4	4
247	R:R:A257	R:R:L241	1.58	No	No	0	8	8
248	R:R:I224	R:R:V219	1.54	No	Yes	0	4	5
249	R:R:I308	R:R:V309	1.54	No	Yes	0	5	7
250	R:R:I67	R:R:T66	1.52	No	No	0	4	5
251	R:R:I126	R:R:T131	1.52	No	No	0	8	7
252	R:R:L335	R:R:V83	1.49	No	Yes	0	6	8
253	R:R:L113	R:R:T66	1.47	No	No	0	9	5
254	R:R:I85	R:R:I99	1.47	No	No	0	3	6
255	R:R:L135	R:R:T189	1.47	No	Yes	0	6	7
256	R:R:Q53	R:R:S50	1.44	No	No	0	3	5
257	R:R:Q138	R:R:S134	1.44	No	No	0	5	5
258	R:R:L129	R:R:M133	1.41	No	No	0	6	5
259	R:R:L327	R:R:M260	1.41	No	No	0	6	8
260	R:R:L262	R:R:L266	1.38	No	No	0	4	5
261	R:R:F193	R:R:T194	1.3	Yes	No	0	4	4
262	R:R:H52	R:R:Q53	1.24	No	No	0	4	3
263	R:R:L241	R:R:R254	1.21	No	No	0	8	6
264	R:R:H245	R:R:R246	1.13	No	No	0	4	4
265	R:R:F132	R:R:F136	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.17	4	0	0
2	R:R:Y65	5.35833	6	2	7
3	R:R:L69	5.0075	4	2	7
4	R:R:F70	6.206	5	0	7
5	R:R:I80	5.025	4	5	9
6	R:R:V83	2.878	5	0	8
7	R:R:F87	5.0025	4	0	5
8	R:R:I93	6.0925	4	0	6
9	R:R:Y97	7.84	4	6	7
10	R:R:D105	7.804	5	1	9
11	R:R:N140	7.9875	4	7	8
12	R:R:F147	10.055	4	3	8
13	R:R:W150	6.772	5	6	7
14	R:R:Y156	5.156	5	0	8
15	R:R:T189	4.31	4	0	7
16	R:R:F193	2.755	4	0	4
17	R:R:V219	3.8575	4	0	5
18	R:R:P226	3.655	4	0	9
19	R:R:I230	5.4475	4	0	8
20	R:R:Y234	7.01	4	0	8
21	R:R:W272	6.91667	6	4	9
22	R:R:E275	4.53	4	4	6
23	R:R:V309	2.544	5	0	7
24	R:R:C318	3.635	4	2	8
25	R:R:N320	7.91	4	1	9
26	R:R:Y324	7.16833	6	1	9
27	R:R:Y338	7.3925	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E275	37.1397	8.98	Yes	Yes	0	0	6
2	R:R:E275	R:R:V309	37.5928	2.85	Yes	Yes	0	6	7
3	R:R:I308	R:R:V309	26.8921	1.54	No	Yes	0	5	7
4	R:R:I308	R:R:L304	24.7051	2.85	No	No	0	5	2
5	R:R:L304	R:R:Q54	18.2223	2.66	No	No	0	2	4
6	R:R:E51	R:R:Q54	13.9108	2.55	No	No	0	2	4
7	R:R:E275	R:R:W272	71.9363	3.27	Yes	Yes	4	6	9
8	R:R:N316	R:R:W272	73.225	15.82	No	Yes	0	9	9
9	R:R:C271	R:R:N316	83.5429	6.3	No	No	0	9	9
10	R:R:C271	R:R:S315	81.231	5.16	No	No	0	9	5
11	R:R:L69	R:R:S315	80.0516	4.5	Yes	No	0	7	5
12	R:R:L69	R:R:Y65	41.2872	8.21	Yes	Yes	2	7	7
13	R:R:F70	R:R:Y65	20.9014	3.09	Yes	Yes	0	7	7
14	R:R:F70	R:R:L113	14.645	12.18	Yes	No	0	7	9
15	R:R:L113	R:R:T66	12.5986	1.47	No	No	0	9	5
16	R:R:I67	R:R:T66	10.5366	1.52	No	No	0	4	5
17	R:R:V116	R:R:Y65	13.0829	2.52	No	Yes	0	7	7
18	R:R:F314	R:R:Y65	11.4426	4.13	No	Yes	2	6	7
19	R:R:C318	R:R:L69	35.1246	3.17	Yes	Yes	2	8	7
20	R:R:C318	R:R:G73	37.9364	3.92	Yes	No	0	8	8
21	R:R:G73	R:R:I72	36.1712	1.76	No	No	0	8	5
22	R:R:I72	R:R:L322	34.3904	4.28	No	No	0	5	6
23	R:R:F268	R:R:W272	48.1372	9.02	No	Yes	0	9	9
24	R:R:F268	R:R:I230	39.3892	7.54	No	Yes	0	9	8
25	R:R:I230	R:R:S152	38.8893	4.64	Yes	No	0	8	9
26	R:R:S152	R:R:Y234	39.1549	5.09	No	Yes	0	9	8
27	R:R:I261	R:R:Y234	56.9945	9.67	No	Yes	0	7	8
28	R:R:I237	R:R:I261	49.1838	2.94	No	No	0	8	7
29	R:R:I237	R:R:Y156	47.5201	3.63	No	Yes	0	8	8
30	R:R:I157	R:R:Y156	40.5608	3.63	No	Yes	0	5	8
31	R:R:F153	R:R:I157	39.0846	7.54	No	No	0	6	5
32	R:R:F153	R:R:W150	38.655	5.01	No	Yes	0	6	7
33	R:R:W150	R:R:Y97	86.1283	13.5	Yes	Yes	6	7	7
34	R:R:I93	R:R:Y97	79.7469	4.84	Yes	Yes	0	6	7
35	R:R:I93	R:R:P94	73.7015	3.39	Yes	No	0	6	8
36	R:R:P94	R:R:T92	72.0378	3.5	No	No	0	8	7
37	R:R:D95	R:R:T92	70.3585	10.12	No	No	0	7	7
38	R:R:D95	R:R:K334	59.9391	4.15	No	No	0	7	5
39	R:R:K334	R:R:V83	42.7166	4.55	No	Yes	0	5	8
40	R:R:N84	R:R:V83	27.8685	2.96	No	Yes	0	7	8
41	R:R:I80	R:R:N84	17.4647	2.83	Yes	No	0	9	7
42	R:R:F331	R:R:I80	10.974	6.28	No	Yes	5	9	9
43	R:R:N316	R:R:N320	100	9.54	No	Yes	0	9	9
44	R:R:D105	R:R:N320	92.9079	9.42	Yes	Yes	1	9	9
45	R:R:D105	R:R:S144	67.8279	4.42	Yes	No	1	9	9
46	R:R:A104	R:R:S144	69.0619	1.71	No	No	0	8	9
47	R:R:A104	R:R:S143	68.0387	1.71	No	No	0	8	7
48	R:R:S143	R:R:W182	63.9772	14.83	No	No	0	7	9
49	R:R:F147	R:R:W182	58.9003	9.02	Yes	No	3	8	9
50	R:R:F147	R:R:I181	57.1897	11.3	Yes	No	0	8	7
51	R:R:I181	R:R:W150	56.6273	4.7	No	Yes	0	7	7
52	R:R:F87	R:R:K334	16.6758	3.72	Yes	No	0	5	5
53	R:R:D95	R:R:M91	11.0443	8.32	No	No	0	7	6
54	R:R:N320	R:R:Y324	24.5958	5.81	Yes	Yes	1	9	9
55	R:R:D105	R:R:S317	53.5031	10.31	Yes	No	0	9	8
56	R:R:L108	R:R:S317	51.9956	6.01	No	No	0	7	8
57	R:R:L108	R:R:N140	50.4725	2.75	No	Yes	0	7	8
58	L:L:?1	R:R:L137	22.4401	6.26	Yes	No	0	0	6
59	R:R:L137	R:R:M133	15.965	2.83	No	No	0	6	5
60	R:R:L129	R:R:M133	13.9108	1.41	No	No	0	6	5
61	R:R:N140	R:R:V139	44.3646	2.96	Yes	No	0	8	5
62	R:R:T189	R:R:V139	42.7634	6.35	Yes	No	0	7	5
63	R:R:L135	R:R:T189	13.3094	1.47	No	Yes	0	6	7
64	R:R:F193	R:R:L135	11.5988	4.87	Yes	No	0	4	6
65	R:R:Q138	R:R:T189	13.3172	5.67	No	Yes	0	5	7
66	R:R:T189	R:R:Y142	17.2147	3.75	Yes	No	0	7	7
67	R:R:F227	R:R:F268	28.2278	4.29	No	No	0	6	9
68	R:R:F227	R:R:F269	26.4547	11.79	No	No	0	6	5
69	R:R:F269	R:R:L273	24.6661	7.31	No	No	0	5	5
70	R:R:F223	R:R:L273	19.2064	3.65	No	No	0	9	5
71	R:R:F223	R:R:N276	17.3553	16.92	No	No	0	9	8
72	R:R:N276	R:R:V219	15.4886	4.43	No	Yes	0	8	5
73	R:R:I261	R:R:V238	15.4651	4.61	No	No	0	7	5
74	R:R:L258	R:R:V238	13.5828	4.47	No	No	0	6	5
75	R:R:L322	R:R:L327	32.5939	4.15	No	No	0	6	6
76	R:R:L327	R:R:M260	30.7662	1.41	No	No	0	6	8
77	R:R:K256	R:R:M260	27.267	2.88	No	No	0	7	8
78	R:R:K256	R:R:R332	23.5257	2.48	No	No	0	7	8
79	R:R:E329	R:R:R332	21.8074	2.33	No	No	0	4	8
80	R:R:E329	R:R:R253	17.9802	5.82	No	No	0	4	5
81	R:R:L250	R:R:R253	16.0509	3.64	No	No	0	3	5
82	R:R:L250	R:R:P252	14.0983	4.93	No	No	0	3	3
83	R:R:P252	R:R:R251	12.13	2.88	No	No	0	3	3
84	R:R:H245	R:R:R251	10.1461	14.67	No	No	0	4	3
85	L:L:?1	R:R:H282	11.2396	3.63	Yes	No	0	0	4
86	R:R:R155	R:R:Y324	22.5885	6.17	No	Yes	0	9	9
87	R:R:R155	R:R:Y234	22.2292	8.23	No	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L137	6.26	0	Yes	No	0	6	0	1
L:L:?1	R:R:E275	8.98	0	Yes	Yes	0	6	0	1
L:L:?1	R:R:H282	3.63	0	Yes	No	0	4	0	1
L:L:?1	R:R:H300	5.81	0	Yes	No	0	4	0	1
R:R:D111	R:R:L137	13.57	0	No	No	7	6	2	1
R:R:E275	R:R:W272	3.27	4	Yes	Yes	6	9	1	2
R:R:A313	R:R:W272	3.89	4	No	Yes	8	9	2	2
R:R:A313	R:R:E275	3.02	4	No	Yes	8	6	2	1
R:R:F278	R:R:H282	7.92	0	No	No	5	4	2	1
R:R:H282	R:R:H302	4.78	0	No	No	4	4	1	2
R:R:E275	R:R:V309	2.85	4	Yes	Yes	6	7	1	2
R:R:L137	R:R:M133	2.83	0	No	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XOF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	248
Number of Links	265
Number of Hubs	27
Number of Links mediated by Hubs	107
Number of Communities	8
Number of Nodes involved in Communities	32
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	33443
Length Of Smallest Path	3
Average Path Length	15.8316
Length of Longest Path	44
Minimum Path Strength	1.34
Average Path Strength	5.98541
Maximum Path Strength	13.54
Minimum Path Correlation	0.7
Average Path Correlation	0.924045
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	45.8645
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.4379
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• steroid hormone binding • binding • steroid binding • lipid binding • hormone binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • chromatin binding • nuclear receptor activity • nuclear steroid receptor activity • DNA-binding transcription factor activity, RNA polymerase II-specific • transcription regulator activity • DNA-binding transcription factor activity • nuclear estrogen receptor activity • ligand-modulated transcription factor activity • G protein-coupled estrogen receptor activity • cellular response to stimulus • positive regulation of cell communication • regulation of biological process • regulation of signaling • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • biological regulation • positive regulation of biological process • regulation of signal transduction • positive regulation of G protein-coupled receptor signaling pathway • cell communication • positive regulation of response to stimulus • regulation of response to stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of biological process • regulation of signaling • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • biological regulation • positive regulation of biological process • regulation of signal transduction • positive regulation of G protein-coupled receptor signaling pathway • cell communication • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of signaling • regulation of cell cycle process • negative regulation of biological process • negative regulation of cell cycle • negative regulation of cell cycle process • negative regulation of cellular process • cell cycle • regulation of cell cycle • cell cycle process • regulation of biosynthetic process • regulation of lipid metabolic process • negative regulation of metabolic process • lipid biosynthetic process • primary metabolic process • negative regulation of lipid biosynthetic process • regulation of primary metabolic process • biosynthetic process • negative regulation of biosynthetic process • metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • negative regulation of lipid metabolic process • lipid metabolic process • positive regulation of organelle organization • regulation of cellular component organization • positive regulation of cellular component organization • apoptotic mitochondrial changes • regulation of release of cytochrome c from mitochondria • cellular component organization • positive regulation of release of cytochrome c from mitochondria • cellular component organization or biogenesis • mitochondrion organization • cell death • regulation of organelle organization • apoptotic signaling pathway • release of cytochrome c from mitochondria • organelle organization • regulation of mitochondrion organization • apoptotic process • programmed cell death • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • positive regulation of protein localization to plasma membrane • regulation of localization • cellular localization • regulation of protein localization • localization • intracellular protein localization • regulation of protein localization to membrane • positive regulation of protein localization to cell periphery • protein localization to cell periphery • protein localization to plasma membrane • positive regulation of protein localization to membrane • regulation of protein localization to cell periphery • localization within membrane • protein localization to membrane • regulation of cellular localization • macromolecule localization • positive regulation of protein localization • regulation of protein localization to plasma membrane • response to lipid • hormone-mediated signaling pathway • response to steroid hormone • cellular response to lipid • cellular response to steroid hormone stimulus • steroid hormone receptor signaling pathway • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • biological process involved in interspecies interaction between organisms • immune response • response to other organism • defense response • defense response to symbiont • response to external stimulus • response to biotic stimulus • immune system process • defense response to other organism • response to stress • innate immune response • response to external biotic stimulus • negative regulation of signaling • negative regulation of intracellular signal transduction • intracellular signal transduction • negative regulation of cell communication • regulation of intracellular signal transduction • intracellular signaling cassette • negative regulation of response to stimulus • regulation of MAPK cascade • negative regulation of signal transduction • negative regulation of ERK1 and ERK2 cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • negative regulation of MAPK cascade • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of ERBB signaling pathway • regulation of epidermal growth factor receptor signaling pathway • epidermal growth factor receptor signaling pathway • enzyme-linked receptor protein signaling pathway • positive regulation of epidermal growth factor receptor signaling pathway • regulation of ERBB signaling pathway • cell surface receptor signaling pathway • ERBB signaling pathway • multicellular organismal process • regulation of leukocyte activation • cell activation • regulation of cell activation • leukocyte activation • negative regulation of cell activation • negative regulation of immune system process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • developmental process • multicellular organism development • anatomical structure development • nervous system development • system development • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • neurogenesis • positive regulation of cell differentiation • cell differentiation • positive regulation of neurogenesis • regulation of multicellular organismal development • positive regulation of cell development • positive regulation of multicellular organismal process • regulation of inositol phosphate biosynthetic process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • positive regulation of phosphate metabolic process • positive regulation of inositol trisphosphate biosynthetic process • regulation of small molecule metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • positive regulation of phosphorus metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of carbohydrate metabolic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cellular response to mineralocorticoid stimulus • response to mineralocorticoid • cellular response to corticosteroid stimulus • response to corticosteroid • fat cell differentiation • negative regulation of developmental process • negative regulation of fat cell differentiation • negative regulation of cell differentiation • regulation of fat cell differentiation • smooth muscle cell differentiation • positive regulation of smooth muscle cell differentiation • regulation of smooth muscle cell differentiation • muscle cell differentiation • regulation of cardiac vascular smooth muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • positive regulation of cardiocyte differentiation • blood vessel development • heart development • positive regulation of cardiac vascular smooth muscle cell differentiation • cardiac vascular smooth muscle cell differentiation • positive regulation of vascular associated smooth muscle cell differentiation • animal organ development • coronary vasculature development • regulation of vascular associated smooth muscle cell differentiation • positive regulation of muscle cell differentiation • vasculature development • cardiocyte differentiation • circulatory system development • regulation of muscle cell differentiation • regulation of cardiocyte differentiation • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • cellular response to glucose stimulus • intracellular glucose homeostasis • response to hexose • cellular response to carbohydrate stimulus • response to monosaccharide • response to carbohydrate • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • cellular component disassembly • membrane organization • nuclear fragmentation involved in apoptotic nuclear change • nuclear membrane organization • execution phase of apoptosis • nucleus organization • cellular component disassembly involved in execution phase of apoptosis • nuclear envelope organization • apoptotic nuclear changes • endomembrane system organization • system process • positive regulation of smooth muscle contraction • positive regulation of uterine smooth muscle contraction • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • uterine smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • regulation of uterine smooth muscle contraction • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • regulation of inflammatory response • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • intracellular receptor signaling pathway • nuclear receptor-mediated steroid hormone signaling pathway • nuclear receptor-mediated signaling pathway • extrinsic apoptotic signaling pathway • positive regulation of apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway • regulation of extrinsic apoptotic signaling pathway • regulation of apoptotic signaling pathway • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • nervous system process • action potential • transmission of nerve impulse • neuronal action potential • regulation of membrane potential • positive regulation of cell population proliferation • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • response to peptide • cellular response to tumor necrosis factor • response to cytokine • cellular response to cytokine stimulus • response to tumor necrosis factor • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • chromosome organization • apoptotic chromosome condensation • chromosome condensation • positive regulation of endothelial cell apoptotic process • endothelial cell apoptotic process • regulation of endothelial cell apoptotic process • transport • modulation of chemical synaptic transmission • positive regulation of neurotransmitter secretion • positive regulation of secretion by cell • synaptic signaling • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • establishment of localization in cell • trans-synaptic signaling • positive regulation of neurotransmitter transport • neurotransmitter secretion • regulation of transport • secretion • regulation of neurotransmitter transport • export from cell • cell-cell signaling • positive regulation of synaptic transmission • neurotransmitter transport • establishment of localization • regulation of secretion • chemical synaptic transmission • signal release from synapse • regulation of trans-synaptic signaling • positive regulation of transport • regulation of neurotransmitter secretion • anterograde trans-synaptic signaling • response to estradiol • cellular response to estradiol stimulus • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of protein modification process • protein metabolic process • positive regulation of protein phosphorylation • protein modification process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • macromolecule modification • regulation of phosphorylation • negative regulation of gene expression • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • positive regulation of hormone secretion • amide transport • positive regulation of peptide secretion • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • positive regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • presynapse • cellular anatomical structure • synapse • cell junction • presynaptic active zone • membrane-bounded organelle • intracellular organelle • organelle envelope • intracellular anatomical structure • organelle • nuclear envelope • nucleus • intracellular membrane-bounded organelle • endomembrane system
Gene Ontology	Cellular Component	• presynapse • cellular anatomical structure • synapse • cell junction • presynaptic active zone • membrane-bounded organelle • intracellular organelle • organelle envelope • intracellular anatomical structure • organelle • nuclear envelope • nucleus • intracellular membrane-bounded organelle • endomembrane system • mitochondrial membrane • mitochondrion • membrane • mitochondrial envelope • cytoplasm • organelle membrane • cytosol • cell periphery • plasma membrane • presynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network • Golgi membrane • bounding membrane of organelle • endosome • intracellular vesicle • recycling endosome • cytoplasmic vesicle • vesicle • dendritic shaft • perinuclear region of cytoplasm • dendritic spine • neuron projection membrane • dendrite membrane • cell leading edge • neuron spine • leading edge membrane • dendritic spine membrane • postsynapse • cell projection membrane • axon • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • dendritic spine head • nucleoplasm • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • cytoplasmic vesicle membrane • vesicle membrane • early endosome • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • postsynaptic density • postsynaptic specialization • asymmetric synapse • keratin filament • polymeric cytoskeletal fiber • intermediate filament cytoskeleton • cytoskeleton • intermediate filament • supramolecular fiber • supramolecular polymer • supramolecular complex • axon terminus • distal axon • neuron projection terminus • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99527
Sequence	>8XOF_nogp_Chain_R S E H Q Q Y V I G L F L S C L Y T I F L F P I G F V G N I L I L V V N I S F R E K M T I P D L Y F I N L A V A D L I L V A D S L I E V F N L H E R Y Y D I A V L C T F M S L F L Q V N M Y S S V F F L T W M S F D R Y I A L A R A M R C S L F R T K H H A R L S C G L I W M A S V S A T L V P F T A V H L V R E V Q W L E V T L G F I V P F A I I G L C Y S L I V R V L V R A H R H R G L R P R R Q K A L R M I L A V V L V F F V C W L P E N V F I S V H L H A H P L T G H I V N L A A F S N S C L N P L I Y S F L G E T F R D K L R L Y I E Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XOF	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOF (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-		2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOG	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOG (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		2.9	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOH	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOH (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOI	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOI (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOJ	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOJ (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.1	2024-04-10	doi.org/10.1038/s41422-024-00963-y

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