psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L137	6.26	Yes	No	0	0	6
2	L:L:?1	R:R:E275	8.98	Yes	Yes	0	0	6
3	L:L:?1	R:R:H282	3.63	Yes	No	0	0	4
4	L:L:?1	R:R:H300	5.81	Yes	No	0	0	4
5	R:R:E51	R:R:H52	13.54	No	No	0	2	4
6	R:R:L59	R:R:Y55	12.89	No	No	0	5	1
7	R:R:F60	R:R:L64	12.18	No	No	0	5	6
8	R:R:S62	R:R:V116	6.46	No	No	0	6	7
9	R:R:F68	R:R:L64	4.87	No	No	0	5	6
10	R:R:L69	R:R:Y65	8.21	Yes	Yes	2	7	7
11	R:R:F70	R:R:Y65	3.09	Yes	Yes	0	7	7
12	R:R:S112	R:R:Y65	10.17	No	Yes	2	8	7
13	R:R:F314	R:R:Y65	4.13	No	Yes	2	6	7
14	R:R:C318	R:R:Y65	4.03	Yes	Yes	2	8	7
15	R:R:F68	R:R:I67	10.05	No	No	0	5	4
16	R:R:L69	R:R:S315	4.5	Yes	No	0	7	5
17	R:R:C318	R:R:L69	3.17	Yes	Yes	2	8	7
18	R:R:L319	R:R:L69	4.15	No	Yes	0	6	7
19	R:R:F70	R:R:P71	4.33	Yes	No	0	7	5
20	R:R:F70	R:R:F74	7.5	Yes	No	0	7	6
21	R:R:F70	R:R:V109	3.93	Yes	No	0	7	6
22	R:R:F70	R:R:L113	12.18	Yes	No	0	7	9
23	R:R:I72	R:R:L322	4.28	No	No	0	5	6
24	R:R:C318	R:R:G73	3.92	Yes	No	0	8	8
25	R:R:F74	R:R:I78	7.54	No	No	0	6	4
26	R:R:L79	R:R:V75	2.98	No	No	0	6	4
27	R:R:F326	R:R:G76	4.52	No	No	0	7	7
28	R:R:D105	R:R:N77	6.73	Yes	No	0	9	9
29	R:R:L106	R:R:N77	4.12	No	No	0	7	9
30	R:R:N77	R:R:P321	13.03	No	No	0	9	9
31	R:R:A102	R:R:I80	3.25	No	Yes	0	9	9
32	R:R:I80	R:R:S325	7.74	Yes	No	5	9	7
33	R:R:F331	R:R:I80	6.28	No	Yes	5	9	9
34	R:R:I99	R:R:L81	4.28	No	No	0	6	7
35	R:R:L81	R:R:V103	4.47	No	No	0	7	5
36	R:R:N84	R:R:V83	2.96	No	Yes	0	7	8
37	R:R:K334	R:R:V83	4.55	No	Yes	0	5	8
38	R:R:V83	R:R:Y338	3.79	Yes	Yes	0	8	5
39	R:R:I99	R:R:N84	8.5	No	No	0	6	7
40	R:R:S86	R:R:Y338	5.09	No	Yes	0	4	5
41	R:R:F87	R:R:K90	8.69	Yes	No	0	5	6
42	R:R:F87	R:R:K334	3.72	Yes	No	0	5	5
43	R:R:F87	R:R:Y338	5.16	Yes	Yes	0	5	5
44	R:R:R175	R:R:R88	5.33	No	No	0	4	4
45	R:R:D95	R:R:M91	8.32	No	No	0	7	6
46	R:R:L96	R:R:M91	4.24	No	No	0	6	6
47	R:R:P94	R:R:T92	3.5	No	No	0	8	7
48	R:R:D95	R:R:T92	10.12	No	No	0	7	7
49	R:R:I93	R:R:P94	3.39	Yes	No	0	6	8
50	R:R:I93	R:R:Y97	4.84	Yes	Yes	0	6	7
51	R:R:I93	R:R:R169	11.27	Yes	No	0	6	7
52	R:R:A174	R:R:I93	4.87	No	Yes	0	7	6
53	R:R:D95	R:R:K334	4.15	No	No	0	7	5
54	R:R:L96	R:R:R175	3.64	No	No	0	6	4
55	R:R:W150	R:R:Y97	13.5	Yes	Yes	6	7	7
56	R:R:D154	R:R:Y97	9.2	No	Yes	0	8	7
57	R:R:S177	R:R:Y97	3.82	No	Yes	6	5	7
58	R:R:F98	R:R:M151	6.22	No	No	0	8	9
59	R:R:F98	R:R:Y324	4.13	No	Yes	0	8	9
60	R:R:F147	R:R:N100	15.71	Yes	No	3	8	9
61	R:R:C178	R:R:N100	6.3	No	No	3	7	9
62	R:R:N100	R:R:W182	4.52	No	No	3	9	9
63	R:R:D105	R:R:L101	8.14	Yes	No	1	9	9
64	R:R:L101	R:R:S144	3	No	No	1	9	9
65	R:R:L101	R:R:L148	6.92	No	No	1	9	8
66	R:R:D105	R:R:S144	4.42	Yes	No	1	9	9
67	R:R:D105	R:R:S317	10.31	Yes	No	0	9	8
68	R:R:D105	R:R:N320	9.42	Yes	Yes	1	9	9
69	R:R:F136	R:R:I107	5.02	No	No	7	4	7
70	R:R:I107	R:R:N140	14.16	No	Yes	7	7	8
71	R:R:L108	R:R:S317	6.01	No	No	0	7	8
72	R:R:C318	R:R:V109	3.42	Yes	No	0	8	6
73	R:R:D111	R:R:L137	13.57	No	No	0	7	6
74	R:R:F314	R:R:S112	15.85	No	No	2	6	8
75	R:R:E115	R:R:H120	17.23	No	No	0	6	3
76	R:R:E115	R:R:F314	4.66	No	No	0	6	6
77	R:R:F117	R:R:V116	9.18	No	No	0	3	7
78	R:R:E121	R:R:H120	9.85	No	No	0	4	3
79	R:R:E121	R:R:Y124	5.61	No	No	0	4	3
80	R:R:R122	R:R:Y123	8.23	No	No	0	4	8
81	R:R:L129	R:R:Y123	3.52	No	No	0	6	8
82	R:R:D125	R:R:V128	4.38	No	No	0	7	3
83	R:R:D125	R:R:L129	4.07	No	No	0	7	6
84	R:R:C130	R:R:I126	3.27	No	No	0	9	8
85	R:R:F193	R:R:L135	4.87	Yes	No	0	4	6
86	R:R:F136	R:R:N140	12.08	No	Yes	7	4	8
87	R:R:Q138	R:R:T189	5.67	No	Yes	0	5	7
88	R:R:E218	R:R:Q138	15.29	No	No	0	5	5
89	R:R:N140	R:R:V139	2.96	Yes	No	0	8	5
90	R:R:T189	R:R:V139	6.35	Yes	No	0	7	5
91	R:R:M141	R:R:W272	5.82	No	Yes	0	7	9
92	R:R:F146	R:R:Y142	9.28	No	No	0	6	7
93	R:R:T189	R:R:Y142	3.75	Yes	No	0	7	7
94	R:R:L217	R:R:Y142	3.52	No	No	0	4	7
95	R:R:S143	R:R:W182	14.83	No	No	0	7	9
96	R:R:S143	R:R:S185	6.52	No	No	0	7	7
97	R:R:P226	R:R:V145	3.53	Yes	No	0	9	8
98	R:R:V145	R:R:W272	3.68	No	Yes	0	8	9
99	R:R:F146	R:R:L221	6.09	No	No	0	6	4
100	R:R:C178	R:R:F147	4.19	No	Yes	3	7	8
101	R:R:F147	R:R:I181	11.3	Yes	No	0	8	7
102	R:R:F147	R:R:W182	9.02	Yes	No	3	8	9
103	R:R:L148	R:R:N320	6.87	No	Yes	1	8	9
104	R:R:L148	R:R:Y324	7.03	No	Yes	1	8	9
105	R:R:P226	R:R:T149	3.5	Yes	No	0	9	8
106	R:R:I229	R:R:T149	6.08	No	No	0	7	8
107	R:R:I230	R:R:T149	6.08	Yes	No	0	8	8
108	R:R:F153	R:R:W150	5.01	No	Yes	0	6	7
109	R:R:S177	R:R:W150	8.65	No	Yes	6	5	7
110	R:R:I181	R:R:W150	4.7	No	Yes	0	7	7
111	R:R:I230	R:R:S152	4.64	Yes	No	0	8	9
112	R:R:C233	R:R:S152	5.16	No	No	0	8	9
113	R:R:S152	R:R:Y234	5.09	No	Yes	0	9	8
114	R:R:F153	R:R:I157	7.54	No	No	0	6	5
115	R:R:D154	R:R:R169	13.1	No	No	0	8	7
116	R:R:R155	R:R:Y234	8.23	No	Yes	0	9	8
117	R:R:R155	R:R:Y324	6.17	No	Yes	0	9	9
118	R:R:I157	R:R:Y156	3.63	No	Yes	0	5	8
119	R:R:A160	R:R:Y156	4	No	Yes	0	7	8
120	R:R:R161	R:R:Y156	5.14	No	Yes	0	6	8
121	R:R:L236	R:R:Y156	9.38	No	Yes	0	3	8
122	R:R:I237	R:R:Y156	3.63	No	Yes	0	8	8
123	R:R:C165	R:R:I157	3.27	No	No	0	6	5
124	R:R:A158	R:R:R169	6.91	No	No	0	8	7
125	R:R:I237	R:R:L159	4.28	No	No	0	8	8
126	R:R:C165	R:R:R161	4.18	No	No	0	6	6
127	R:R:H173	R:R:T170	9.58	No	No	0	3	6
128	R:R:K171	R:R:R175	4.95	No	No	0	4	4
129	R:R:H172	R:R:H173	7.17	No	No	0	3	3
130	R:R:L190	R:R:V186	2.98	No	No	0	4	4
131	R:R:P192	R:R:V191	3.53	No	No	0	4	7
132	R:R:L217	R:R:P192	4.93	No	No	0	4	4
133	R:R:V196	R:R:V211	12.83	No	No	8	5	4
134	R:R:V196	R:R:V214	3.21	No	No	8	5	4
135	R:R:V211	R:R:V214	4.81	No	No	8	4	4
136	R:R:E218	R:R:V214	5.7	No	No	0	5	4
137	R:R:L283	R:R:Q215	6.65	No	No	0	5	4
138	R:R:L283	R:R:W216	9.11	No	No	0	5	4
139	R:R:L217	R:R:L221	4.15	No	No	0	4	4
140	R:R:N276	R:R:V219	4.43	No	Yes	0	8	5
141	R:R:I279	R:R:V219	4.61	No	Yes	0	5	5
142	R:R:S280	R:R:V219	4.85	No	Yes	0	5	5
143	R:R:G222	R:R:P226	4.06	No	Yes	0	5	9
144	R:R:F223	R:R:L273	3.65	No	No	0	9	5
145	R:R:F223	R:R:N276	16.92	No	No	0	9	8
146	R:R:P226	R:R:V225	3.53	Yes	No	0	9	5
147	R:R:I229	R:R:V225	3.07	No	No	0	7	5
148	R:R:F227	R:R:F268	4.29	No	No	0	6	9
149	R:R:F227	R:R:F269	11.79	No	No	0	6	5
150	R:R:G231	R:R:I230	3.53	No	Yes	0	4	8
151	R:R:F268	R:R:I230	7.54	No	Yes	0	9	8
152	R:R:L232	R:R:L236	4.15	No	No	0	4	3
153	R:R:I261	R:R:Y234	9.67	No	Yes	0	7	8
154	R:R:V265	R:R:Y234	5.05	No	Yes	0	7	8
155	R:R:I237	R:R:I261	2.94	No	No	0	8	7
156	R:R:L258	R:R:V238	4.47	No	No	0	6	5
157	R:R:I261	R:R:V238	4.61	No	No	0	7	5
158	R:R:R239	R:R:R243	13.86	No	No	0	3	3
159	R:R:L241	R:R:L258	5.54	No	No	0	8	6
160	R:R:L258	R:R:V242	2.98	No	No	0	6	4
161	R:R:H245	R:R:R251	14.67	No	No	0	4	3
162	R:R:H245	R:R:Q255	7.42	No	No	0	4	5
163	R:R:G249	R:R:R254	6	No	No	0	3	6
164	R:R:L250	R:R:P252	4.93	No	No	0	3	3
165	R:R:L250	R:R:R253	3.64	No	No	0	3	5
166	R:R:E329	R:R:R253	5.82	No	No	0	4	5
167	R:R:K256	R:R:R259	3.71	No	No	0	7	5
168	R:R:G328	R:R:M260	3.49	No	No	0	8	8
169	R:R:I323	R:R:V264	6.14	No	No	1	7	8
170	R:R:V264	R:R:Y324	12.62	No	Yes	1	8	9
171	R:R:L319	R:R:V267	4.47	No	No	0	6	7
172	R:R:F268	R:R:W272	9.02	No	Yes	0	9	9
173	R:R:F269	R:R:L273	7.31	No	No	0	5	5
174	R:R:C271	R:R:S315	5.16	No	No	0	9	5
175	R:R:C271	R:R:N316	6.3	No	No	0	9	9
176	R:R:E275	R:R:W272	3.27	Yes	Yes	4	6	9
177	R:R:A313	R:R:W272	3.89	No	Yes	4	8	9
178	R:R:N316	R:R:W272	15.82	No	Yes	0	9	9
179	R:R:L273	R:R:V277	2.98	No	No	0	5	5
180	R:R:P274	R:R:V309	3.53	No	Yes	0	9	7
181	R:R:A313	R:R:E275	3.02	No	Yes	4	8	6
182	R:R:F278	R:R:H282	7.92	No	No	0	5	4
183	R:R:F278	R:R:T305	3.89	No	No	0	5	5
184	R:R:H282	R:R:H302	4.78	No	No	0	4	4
185	R:R:A301	R:R:H302	7.32	No	No	0	5	4
186	R:R:H307	R:R:L311	11.57	No	No	0	4	5
187	R:R:N310	R:R:V309	2.96	No	Yes	0	5	7
188	R:R:N316	R:R:N320	9.54	No	Yes	0	9	9
189	R:R:N320	R:R:Y324	5.81	Yes	Yes	1	9	9
190	R:R:L322	R:R:L327	4.15	No	No	0	6	6
191	R:R:I323	R:R:Y324	7.25	No	Yes	1	7	9
192	R:R:F331	R:R:S325	14.53	No	No	5	9	7
193	R:R:F326	R:R:F331	5.36	No	No	0	7	9
194	R:R:D333	R:R:E329	6.5	No	No	0	4	4
195	R:R:I339	R:R:L335	4.28	No	No	0	5	6
196	R:R:K342	R:R:Y338	15.53	No	Yes	0	5	5
197	R:R:K342	R:R:Q341	4.07	No	No	0	5	2
198	R:R:P252	R:R:R251	2.88	No	No	0	3	3
199	R:R:K256	R:R:M260	2.88	No	No	0	7	8
200	R:R:I57	R:R:L61	2.85	No	No	0	4	5
201	R:R:I57	R:R:L304	2.85	No	No	0	4	2
202	R:R:E213	R:R:V196	2.85	No	No	0	3	5
203	R:R:E275	R:R:V309	2.85	Yes	Yes	0	6	7
204	R:R:I279	R:R:L283	2.85	No	No	0	5	5
205	R:R:I308	R:R:L304	2.85	No	No	0	5	2
206	R:R:I80	R:R:N84	2.83	Yes	No	0	9	7
207	R:R:L137	R:R:M133	2.83	No	No	0	6	5
208	R:R:D111	R:R:I114	2.8	No	No	0	7	6
209	R:R:H307	R:R:S62	2.79	No	No	0	4	6
210	R:R:A244	R:R:R254	2.77	No	No	0	5	6
211	R:R:L108	R:R:N140	2.75	No	Yes	0	7	8
212	R:R:E89	R:R:K90	2.7	No	No	0	5	6
213	R:R:L304	R:R:Q54	2.66	No	No	0	2	4
214	R:R:F193	R:R:T131	2.59	Yes	No	0	4	7
215	R:R:E51	R:R:Q54	2.55	No	No	0	2	4
216	R:R:H120	R:R:N118	2.55	No	No	0	3	5
217	R:R:V116	R:R:Y65	2.52	No	Yes	0	7	7
218	R:R:K256	R:R:R332	2.48	No	No	0	7	8
219	R:R:F87	R:R:L337	2.44	Yes	No	0	5	4
220	R:R:F117	R:R:L119	2.44	No	No	0	3	5
221	R:R:T220	R:R:W216	2.43	No	No	0	5	4
222	R:R:E329	R:R:R332	2.33	No	No	0	4	8
223	R:R:F193	R:R:H197	2.26	Yes	No	0	4	5
224	R:R:H247	R:R:R246	2.26	No	No	0	3	4
225	R:R:H247	R:R:R248	2.26	No	No	0	3	2
226	R:R:E51	R:R:Y55	2.24	No	No	0	2	1
227	R:R:F168	R:R:W150	2	No	Yes	0	1	7
228	R:R:C178	R:R:G179	1.96	No	No	0	7	4
229	R:R:A312	R:R:P274	1.87	No	No	0	7	9
230	R:R:G231	R:R:S235	1.86	No	No	0	4	3
231	R:R:G76	R:R:V75	1.84	No	No	0	7	4
232	R:R:G306	R:R:V309	1.84	No	Yes	0	4	7
233	R:R:G73	R:R:I72	1.76	No	No	0	8	5
234	R:R:A104	R:R:S143	1.71	No	No	0	8	7
235	R:R:A104	R:R:S144	1.71	No	No	0	8	9
236	R:R:C271	R:R:V270	1.71	No	No	0	9	6
237	R:R:A127	R:R:V128	1.7	No	No	0	3	3
238	R:R:A160	R:R:V240	1.7	No	No	0	7	5
239	R:R:C63	R:R:I67	1.64	No	No	0	4	4
240	R:R:S185	R:R:V186	1.62	No	No	0	7	4
241	R:R:A162	R:R:M163	1.61	No	No	0	8	5
242	R:R:V82	R:R:V83	1.6	No	Yes	0	3	8
243	R:R:V277	R:R:V281	1.6	No	No	0	5	4
244	R:R:G58	R:R:H307	1.59	No	No	0	3	4
245	R:R:P303	R:R:Q54	1.58	No	No	0	3	4
246	R:R:A188	R:R:L221	1.58	No	No	0	4	4
247	R:R:A257	R:R:L241	1.58	No	No	0	8	8
248	R:R:I224	R:R:V219	1.54	No	Yes	0	4	5
249	R:R:I308	R:R:V309	1.54	No	Yes	0	5	7
250	R:R:I67	R:R:T66	1.52	No	No	0	4	5
251	R:R:I126	R:R:T131	1.52	No	No	0	8	7
252	R:R:L335	R:R:V83	1.49	No	Yes	0	6	8
253	R:R:L113	R:R:T66	1.47	No	No	0	9	5
254	R:R:I85	R:R:I99	1.47	No	No	0	3	6
255	R:R:L135	R:R:T189	1.47	No	Yes	0	6	7
256	R:R:Q53	R:R:S50	1.44	No	No	0	3	5
257	R:R:Q138	R:R:S134	1.44	No	No	0	5	5
258	R:R:L129	R:R:M133	1.41	No	No	0	6	5
259	R:R:L327	R:R:M260	1.41	No	No	0	6	8
260	R:R:L262	R:R:L266	1.38	No	No	0	4	5
261	R:R:F193	R:R:T194	1.3	Yes	No	0	4	4
262	R:R:H52	R:R:Q53	1.24	No	No	0	4	3
263	R:R:L241	R:R:R254	1.21	No	No	0	8	6
264	R:R:H245	R:R:R246	1.13	No	No	0	4	4
265	R:R:F132	R:R:F136	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.17	4	0	0
2	R:R:Y65	5.35833	6	2	7
3	R:R:L69	5.0075	4	2	7
4	R:R:F70	6.206	5	0	7
5	R:R:I80	5.025	4	5	9
6	R:R:V83	2.878	5	0	8
7	R:R:F87	5.0025	4	0	5
8	R:R:I93	6.0925	4	0	6
9	R:R:Y97	7.84	4	6	7
10	R:R:D105	7.804	5	1	9
11	R:R:N140	7.9875	4	7	8
12	R:R:F147	10.055	4	3	8
13	R:R:W150	6.772	5	6	7
14	R:R:Y156	5.156	5	0	8
15	R:R:T189	4.31	4	0	7
16	R:R:F193	2.755	4	0	4
17	R:R:V219	3.8575	4	0	5
18	R:R:P226	3.655	4	0	9
19	R:R:I230	5.4475	4	0	8
20	R:R:Y234	7.01	4	0	8
21	R:R:W272	6.91667	6	4	9
22	R:R:E275	4.53	4	4	6
23	R:R:V309	2.544	5	0	7
24	R:R:C318	3.635	4	2	8
25	R:R:N320	7.91	4	1	9
26	R:R:Y324	7.16833	6	1	9
27	R:R:Y338	7.3925	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E275	37.1397	8.98	Yes	Yes	0	0	6
2	R:R:E275	R:R:V309	37.5928	2.85	Yes	Yes	0	6	7
3	R:R:I308	R:R:V309	26.8921	1.54	No	Yes	0	5	7
4	R:R:I308	R:R:L304	24.7051	2.85	No	No	0	5	2
5	R:R:L304	R:R:Q54	18.2223	2.66	No	No	0	2	4
6	R:R:E51	R:R:Q54	13.9108	2.55	No	No	0	2	4
7	R:R:E275	R:R:W272	71.9363	3.27	Yes	Yes	4	6	9
8	R:R:N316	R:R:W272	73.225	15.82	No	Yes	0	9	9
9	R:R:C271	R:R:N316	83.5429	6.3	No	No	0	9	9
10	R:R:C271	R:R:S315	81.231	5.16	No	No	0	9	5
11	R:R:L69	R:R:S315	80.0516	4.5	Yes	No	0	7	5
12	R:R:L69	R:R:Y65	41.2872	8.21	Yes	Yes	2	7	7
13	R:R:F70	R:R:Y65	20.9014	3.09	Yes	Yes	0	7	7
14	R:R:F70	R:R:L113	14.645	12.18	Yes	No	0	7	9
15	R:R:L113	R:R:T66	12.5986	1.47	No	No	0	9	5
16	R:R:I67	R:R:T66	10.5366	1.52	No	No	0	4	5
17	R:R:V116	R:R:Y65	13.0829	2.52	No	Yes	0	7	7
18	R:R:F314	R:R:Y65	11.4426	4.13	No	Yes	2	6	7
19	R:R:C318	R:R:L69	35.1246	3.17	Yes	Yes	2	8	7
20	R:R:C318	R:R:G73	37.9364	3.92	Yes	No	0	8	8
21	R:R:G73	R:R:I72	36.1712	1.76	No	No	0	8	5
22	R:R:I72	R:R:L322	34.3904	4.28	No	No	0	5	6
23	R:R:F268	R:R:W272	48.1372	9.02	No	Yes	0	9	9
24	R:R:F268	R:R:I230	39.3892	7.54	No	Yes	0	9	8
25	R:R:I230	R:R:S152	38.8893	4.64	Yes	No	0	8	9
26	R:R:S152	R:R:Y234	39.1549	5.09	No	Yes	0	9	8
27	R:R:I261	R:R:Y234	56.9945	9.67	No	Yes	0	7	8
28	R:R:I237	R:R:I261	49.1838	2.94	No	No	0	8	7
29	R:R:I237	R:R:Y156	47.5201	3.63	No	Yes	0	8	8
30	R:R:I157	R:R:Y156	40.5608	3.63	No	Yes	0	5	8
31	R:R:F153	R:R:I157	39.0846	7.54	No	No	0	6	5
32	R:R:F153	R:R:W150	38.655	5.01	No	Yes	0	6	7
33	R:R:W150	R:R:Y97	86.1283	13.5	Yes	Yes	6	7	7
34	R:R:I93	R:R:Y97	79.7469	4.84	Yes	Yes	0	6	7
35	R:R:I93	R:R:P94	73.7015	3.39	Yes	No	0	6	8
36	R:R:P94	R:R:T92	72.0378	3.5	No	No	0	8	7
37	R:R:D95	R:R:T92	70.3585	10.12	No	No	0	7	7
38	R:R:D95	R:R:K334	59.9391	4.15	No	No	0	7	5
39	R:R:K334	R:R:V83	42.7166	4.55	No	Yes	0	5	8
40	R:R:N84	R:R:V83	27.8685	2.96	No	Yes	0	7	8
41	R:R:I80	R:R:N84	17.4647	2.83	Yes	No	0	9	7
42	R:R:F331	R:R:I80	10.974	6.28	No	Yes	5	9	9
43	R:R:N316	R:R:N320	100	9.54	No	Yes	0	9	9
44	R:R:D105	R:R:N320	92.9079	9.42	Yes	Yes	1	9	9
45	R:R:D105	R:R:S144	67.8279	4.42	Yes	No	1	9	9
46	R:R:A104	R:R:S144	69.0619	1.71	No	No	0	8	9
47	R:R:A104	R:R:S143	68.0387	1.71	No	No	0	8	7
48	R:R:S143	R:R:W182	63.9772	14.83	No	No	0	7	9
49	R:R:F147	R:R:W182	58.9003	9.02	Yes	No	3	8	9
50	R:R:F147	R:R:I181	57.1897	11.3	Yes	No	0	8	7
51	R:R:I181	R:R:W150	56.6273	4.7	No	Yes	0	7	7
52	R:R:F87	R:R:K334	16.6758	3.72	Yes	No	0	5	5
53	R:R:D95	R:R:M91	11.0443	8.32	No	No	0	7	6
54	R:R:N320	R:R:Y324	24.5958	5.81	Yes	Yes	1	9	9
55	R:R:D105	R:R:S317	53.5031	10.31	Yes	No	0	9	8
56	R:R:L108	R:R:S317	51.9956	6.01	No	No	0	7	8
57	R:R:L108	R:R:N140	50.4725	2.75	No	Yes	0	7	8
58	L:L:?1	R:R:L137	22.4401	6.26	Yes	No	0	0	6
59	R:R:L137	R:R:M133	15.965	2.83	No	No	0	6	5
60	R:R:L129	R:R:M133	13.9108	1.41	No	No	0	6	5
61	R:R:N140	R:R:V139	44.3646	2.96	Yes	No	0	8	5
62	R:R:T189	R:R:V139	42.7634	6.35	Yes	No	0	7	5
63	R:R:L135	R:R:T189	13.3094	1.47	No	Yes	0	6	7
64	R:R:F193	R:R:L135	11.5988	4.87	Yes	No	0	4	6
65	R:R:Q138	R:R:T189	13.3172	5.67	No	Yes	0	5	7
66	R:R:T189	R:R:Y142	17.2147	3.75	Yes	No	0	7	7
67	R:R:F227	R:R:F268	28.2278	4.29	No	No	0	6	9
68	R:R:F227	R:R:F269	26.4547	11.79	No	No	0	6	5
69	R:R:F269	R:R:L273	24.6661	7.31	No	No	0	5	5
70	R:R:F223	R:R:L273	19.2064	3.65	No	No	0	9	5
71	R:R:F223	R:R:N276	17.3553	16.92	No	No	0	9	8
72	R:R:N276	R:R:V219	15.4886	4.43	No	Yes	0	8	5
73	R:R:I261	R:R:V238	15.4651	4.61	No	No	0	7	5
74	R:R:L258	R:R:V238	13.5828	4.47	No	No	0	6	5
75	R:R:L322	R:R:L327	32.5939	4.15	No	No	0	6	6
76	R:R:L327	R:R:M260	30.7662	1.41	No	No	0	6	8
77	R:R:K256	R:R:M260	27.267	2.88	No	No	0	7	8
78	R:R:K256	R:R:R332	23.5257	2.48	No	No	0	7	8
79	R:R:E329	R:R:R332	21.8074	2.33	No	No	0	4	8
80	R:R:E329	R:R:R253	17.9802	5.82	No	No	0	4	5
81	R:R:L250	R:R:R253	16.0509	3.64	No	No	0	3	5
82	R:R:L250	R:R:P252	14.0983	4.93	No	No	0	3	3
83	R:R:P252	R:R:R251	12.13	2.88	No	No	0	3	3
84	R:R:H245	R:R:R251	10.1461	14.67	No	No	0	4	3
85	L:L:?1	R:R:H282	11.2396	3.63	Yes	No	0	0	4
86	R:R:R155	R:R:Y324	22.5885	6.17	No	Yes	0	9	9
87	R:R:R155	R:R:Y234	22.2292	8.23	No	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L137	6.26	0	Yes	No	0	6	0	1
L:L:?1	R:R:E275	8.98	0	Yes	Yes	0	6	0	1
L:L:?1	R:R:H282	3.63	0	Yes	No	0	4	0	1
L:L:?1	R:R:H300	5.81	0	Yes	No	0	4	0	1
R:R:D111	R:R:L137	13.57	0	No	No	7	6	2	1
R:R:E275	R:R:W272	3.27	4	Yes	Yes	6	9	1	2
R:R:A313	R:R:W272	3.89	4	No	Yes	8	9	2	2
R:R:A313	R:R:E275	3.02	4	No	Yes	8	6	2	1
R:R:F278	R:R:H282	7.92	0	No	No	5	4	2	1
R:R:H282	R:R:H302	4.78	0	No	No	4	4	1	2
R:R:E275	R:R:V309	2.85	4	Yes	Yes	6	7	1	2
R:R:L137	R:R:M133	2.83	0	No	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XOF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	248
Number of Links	265
Number of Hubs	27
Number of Links mediated by Hubs	107
Number of Communities	8
Number of Nodes involved in Communities	32
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	33443
Length Of Smallest Path	3
Average Path Length	15.8316
Length of Longest Path	44
Minimum Path Strength	1.34
Average Path Strength	5.98541
Maximum Path Strength	13.54
Minimum Path Correlation	0.7
Average Path Correlation	0.924047
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	45.8726
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.4379
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99527
Sequence	>8XOF_nogp_Chain_R S E H Q Q Y V I G L F L S C L Y T I F L F P I G F V G N I L I L V V N I S F R E K M T I P D L Y F I N L A V A D L I L V A D S L I E V F N L H E R Y Y D I A V L C T F M S L F L Q V N M Y S S V F F L T W M S F D R Y I A L A R A M R C S L F R T K H H A R L S C G L I W M A S V S A T L V P F T A V H L V R E V Q W L E V T L G F I V P F A I I G L C Y S L I V R V L V R A H R H R G L R P R R Q K A L R M I L A V V L V F F V C W L P E N V F I S V H L H A H P L T G H I V N L A A F S N S C L N P L I Y S F L G E T F R D K L R L Y I E Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XOG	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-04-10	To be published
	8XOG (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		2.9	2024-04-10	To be published
	8XOJ	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2024-04-10	To be published
	8XOJ (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.1	2024-04-10	To be published
	8XOI	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	To be published
	8XOI (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	To be published
	8XOH	A	Orphan	Orphan	GPR30	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2024-04-10	To be published
	8XOH (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	-	-		3.2	2024-04-10	To be published
	8XOF	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y
	8XOF (No Gprot)	A	Orphan	Orphan	GPR30	Homo sapiens	Lys05	-		2.6	2024-04-10	doi.org/10.1038/s41422-024-00963-y

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XOF_nogp.zip

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