Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L41 6.5275436
2A:A:L43 4.445437
3A:A:L44 8.72419
4A:A:L45 5.6438
5A:A:L46 6.08418
6A:A:K53 6.085439
7A:A:F219 8.225638
8A:A:H220 10.67417
9A:A:M221 3.72833638
10A:A:F222 9.8325417
11A:A:Q227 4.72619
12A:A:R228 5.428509
13A:A:R231 7.1375419
14A:A:K233 6.775619
15A:A:W234 6.905619
16A:A:I235 4.672519
17A:A:F238 11.3525419
18A:A:I244 4.325418
19A:A:I245 3.482537
20A:A:F246 6.128519
21A:A:V247 4.502537
22A:A:L270 5.91406
23A:A:D272 6.6075418
24A:A:F273 5.87286719
25A:A:W277 8.79714716
26A:A:W281 8.07715
27A:A:L282 5.6275419
28A:A:I288 3.98509
29A:A:L289 5.914519
30A:A:F290 5.555639
31A:A:L291 4.435618
32A:A:N292 7.115439
33A:A:K293 7639
34A:A:Q294 7.126516
35A:A:L297 3.1775418
36A:A:F312 4.714188
37A:A:F315 11.182506
38A:A:E330 4.155403
39A:A:K338 7.295415
40A:A:F340 7.685187
41A:A:F345 6.736518
42A:A:Y360 8.536676138
43A:A:F363 8.77515
44A:A:T364 7.0925439
45A:A:N371 5.442539
46A:A:R373 5.6675435
47A:A:R374 7.638534
48A:A:F376 6.765438
49A:A:D378 8.35254137
50A:A:I383 3.6925438
51A:A:L388 5.7875428
52A:A:Y391 11.672524
53A:A:L393 6.565428
54B:B:E10 5.28754208
55B:B:Q13 4.514201
56B:B:L14 5.424208
57B:B:R22 7.9475446
58B:B:L30 4.37405
59B:B:I37 4.39472
60B:B:V40 4.234573
61B:B:I43 4.1225473
62B:B:L51 7.094559
63B:B:H54 9.804559
64B:B:M61 4.8875456
65B:B:W63 6.83657
66B:B:L70 6.4375455
67B:B:V71 5.525408
68B:B:S72 6.0825459
69B:B:Q75 6.63409
70B:B:D76 9.5125409
71B:B:K78 4.71508
72B:B:L79 6.6325487
73B:B:I80 8.935458
74B:B:I81 4.898587
75B:B:W82 8.38429759
76B:B:Y85 12.985454
77B:B:N88 5.5475407
78B:B:K89 7.06559
79B:B:H91 6.23485
80B:B:I93 5.834587
81B:B:L95 5.662588
82B:B:W99 10.1417619
83B:B:M101 7.59519
84B:B:N110 6.5375414
85B:B:Y111 6.124514
86B:B:L117 5.216519
87B:B:N119 5.2925419
88B:B:C121 3.7375418
89B:B:I123 3.61833616
90B:B:Y124 5.14333686
91B:B:T128 5.0475403
92B:B:V133 6.15484
93B:B:H142 7.33619
94B:B:Y145 6.47444918
95B:B:C148 5.43466
96B:B:C149 3.84418
97B:B:F151 5.745609
98B:B:I157 5.666517
99B:B:V158 3.9175405
100B:B:T159 4.75619
101B:B:S160 5.5425466
102B:B:D163 9.895419
103B:B:C166 4.235468
104B:B:W169 9.87833618
105B:B:F180 7.698567
106B:B:H183 8.57669
107B:B:D186 8.3275419
108B:B:V187 5.0875469
109B:B:F199 7.65569
110B:B:S201 4.955469
111B:B:C204 3.5775417
112B:B:D205 7.7925469
113B:B:K209 11.61466
114B:B:L210 5.3125405
115B:B:W211 8.135668
116B:B:F222 7.178548
117B:B:H225 9.37333649
118B:B:D228 7.766519
119B:B:I232 5.09448
120B:B:F235 7.895416
121B:B:P236 6.725417
122B:B:F241 8.206546
123B:B:T243 6.62448
124B:B:D247 6.718549
125B:B:T249 6.85446
126B:B:R251 11.288548
127B:B:F253 6.51857746
128B:B:D254 5.7554229
129B:B:D258 12.525447
130B:B:Q259 5.145406
131B:B:L261 5.2025405
132B:B:Y264 6.598515
133B:B:I269 3.882514
134B:B:F278 6.678517
135B:B:R283 8.594579
136B:B:L284 4.7875475
137B:B:L285 5.47416
138B:B:Y289 6.88857717
139B:B:D290 6.15516
140B:B:N295 6.82833616
141B:B:V296 3.8125405
142B:B:W297 5.484518
143B:B:L300 7.238576
144B:B:K301 5.17505
145B:B:L308 8.655407
146B:B:H311 7.94167699
147B:B:R314 11.576518
148B:B:L318 4.516506
149B:B:M325 6.64455
150B:B:V327 4.555406
151B:B:W332 8.515619
152B:B:D333 8.1875499
153B:B:L336 5.076557
154B:B:K337 9.81496
155B:B:I338 5.3325455
156B:B:W339 10.026599
157G:G:R27 6.245648
158G:G:Y40 10.29416
159G:G:D48 6.66579
160G:G:P49 4.315407
161G:G:L51 3.69333676
162G:G:P60 7.4025459
163G:G:F61 5.05333958
164R:R:Y65 4.411437105
165R:R:L69 3.40754107
166R:R:F70 5.504507
167R:R:N77 7.44409
168R:R:I80 6.2754159
169R:R:V83 5.125407
170R:R:M91 5.6475427
171R:R:I93 5.4775426
172R:R:P94 7.255627
173R:R:D95 8.6675428
174R:R:Y97 6.165627
175R:R:L101 5.88429
176R:R:D105 8.592529
177R:R:L108 5.07407
178R:R:H120 6.1654164
179R:R:Y123 6.066676168
180R:R:L135 4.35754115
181R:R:Y142 7.1525117
182R:R:S143 6.05754147
183R:R:S144 3.835429
184R:R:F147 8.8465148
185R:R:W150 7.602527
186R:R:R155 12.085429
187R:R:Y156 5.486508
188R:R:I157 5.805405
189R:R:R169 6.748527
190R:R:T189 4.6354117
191R:R:V219 2.9725406
192R:R:F223 8.4954128
193R:R:P226 3.1475409
194R:R:I230 4.666508
195R:R:Y234 6.36529
196R:R:R248 8.6054134
197R:R:F268 7.24754129
198R:R:F269 5.264125
199R:R:W272 8.5345129
200R:R:L273 44125
201R:R:F278 7.9665305
202R:R:L283 6.16254295
203R:R:L304 5.5875401
204R:R:H307 7.1325403
205R:R:F314 6.0754107
206R:R:N320 8.784529
207R:R:Y324 6.95429729
208R:R:F326 5.1165157
209R:R:F331 7.1045158
210R:R:K334 5.12425
211R:R:Y338 5.27254255
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:K78 20.01538.3YesYes098
2B:B:D76 B:B:L55 10.859816.29YesNo096
3A:A:Y37 B:B:L55 11.47423.52NoNo036
4A:A:R42 A:A:Y37 22.740117.49NoNo093
5A:A:F222 A:A:R42 22.94435.34YesNo079
6B:B:A56 B:B:D76 10.85734.63NoYes079
7A:A:Y37 B:B:A56 11.06215.34NoNo037
8A:A:N279 A:A:W281 45.13344.52NoYes185
9A:A:I235 A:A:N279 45.21774.25YesNo198
10A:A:I235 A:A:R231 45.10133.76YesYes199
11A:A:D272 A:A:R231 85.938410.72YesYes189
12A:A:D272 A:A:F246 86.12637.17YesYes189
13A:A:F246 A:A:L289 1004.87YesYes199
14A:A:L289 A:A:L291 1006.92YesYes198
15A:A:I341 A:A:L291 1002.85NoYes088
16A:A:I341 A:A:L266 1002.85NoNo088
17A:A:D252 A:A:L266 1006.79NoNo1788
18A:A:D252 A:A:R265 1007.15NoNo089
19A:A:N50 A:A:R265 1006.03NoNo099
20A:A:D249 A:A:N50 1006.73NoNo089
21A:A:D249 A:A:K293 10011.06NoYes089
22A:A:K293 A:A:N292 10013.99YesYes399
23A:A:N292 A:A:V247 78.71692.96YesYes397
24A:A:K53 A:A:V247 43.67524.55YesYes397
25A:A:K53 A:A:L45 43.77617.05YesYes398
26A:A:L45 A:A:M221 26.33197.07YesYes388
27A:A:L43 A:A:M221 17.70544.24YesYes378
28A:A:F219 A:A:L43 53.2066.09YesYes387
29A:A:F219 A:A:L41 61.70558.53YesYes386
30A:A:I245 A:A:L45 17.51432.85YesYes378
31A:A:I245 A:A:L43 88.23654.28YesYes377
32A:A:F290 A:A:V247 35.16143.93YesYes397
33A:A:F290 A:A:I288 35.47563.77YesYes099
34A:A:I245 A:A:I288 35.59442.94YesYes079
35A:A:N292 A:A:T364 35.26835.85YesYes399
36A:A:F290 A:A:T364 35.25197.78YesYes399
37A:A:F290 A:A:I375 35.14835.02YesNo099
38A:A:I245 A:A:I375 35.14984.42YesNo079
39A:A:C379 A:A:L43 52.70993.17NoYes387
40A:A:C379 A:A:T242 52.67623.38NoNo388
41A:A:I383 A:A:L41 61.52734.28YesYes386
42A:A:I383 A:A:T242 52.64243.04YesNo388
43A:A:L44 A:A:L46 14.46289.69YesYes198
44A:A:F238 B:B:W99 28.128617.04YesYes199
45A:A:F222 B:B:W99 26.837719.04YesYes179
46A:A:I276 A:A:L46 14.97155.71NoYes188
47A:A:W234 B:B:Y145 25.36225.79YesYes198
48A:A:W281 B:B:D290 27.07584.47YesYes156
49A:A:I383 R:R:A162 1001.62YesNo088
50A:A:N387 R:R:A162 1001.56NoNo088
51A:A:N387 R:R:A158 1004.69NoNo088
52R:R:A158 R:R:R169 1006.91NoYes087
53R:R:P94 R:R:R169 45.68372.88YesYes277
54A:A:Y391 R:R:P94 23.70818.08YesYes247
55A:A:Y391 R:R:R155 47.225120.58YesYes249
56R:R:D154 R:R:R169 41.819210.72NoYes287
57A:A:Y391 R:R:D154 23.693512.64YesNo248
58R:R:I93 R:R:R169 18.217210.02YesYes267
59R:R:I93 R:R:Y97 18.04493.63YesYes267
60R:R:D154 R:R:Y97 18.03899.2NoYes287
61R:R:F98 R:R:P94 17.95324.33NoYes287
62B:B:S147 B:B:Y145 17.30517.63NoYes098
63B:B:S147 B:B:S160 17.20083.26NoYes096
64B:B:I93 B:B:P94 16.31263.39YesNo075
65B:B:S275 B:B:T274 17.40563.2NoNo088
66B:B:L318 B:B:S275 17.20057.51YesNo068
67B:B:L198 B:B:L210 10.57636.92NoYes035
68B:B:D212 B:B:L198 10.88294.07NoNo093
69B:B:R214 B:B:V213 12.1387.85NoNo094
70B:B:E215 B:B:R214 11.50673.49NoNo039
71B:B:C271 B:B:D290 18.20873.11NoYes156
72B:B:C271 B:B:Y289 17.89694.03NoYes157
73B:B:W297 B:B:Y289 13.1245.79YesYes187
74B:B:W297 B:B:Y264 12.92767.72YesYes185
75R:R:M151 R:R:Y97 35.73164.79NoYes087
76R:R:M151 R:R:Y324 53.32854.79NoYes089
77R:R:N320 R:R:Y324 62.87785.81YesYes299
78R:R:N316 R:R:N320 30.11212.26NoYes099
79R:R:C271 R:R:N316 14.38033.15NoNo089
80R:R:C271 R:R:S315 13.93023.44NoNo085
81R:R:L69 R:R:S315 26.95484.5YesNo075
82R:R:L69 R:R:Y65 21.56413.52YesYes1075
83R:R:L311 R:R:Y65 12.58494.69NoYes055
84R:R:H307 R:R:L311 11.685614.14YesNo035
85R:R:G58 R:R:H307 12.13881.59NoYes043
86R:R:F98 R:R:M151 17.86516.22NoNo088
87R:R:R155 R:R:Y324 35.56456.17YesYes299
88R:R:I323 R:R:Y324 15.27256.04NoYes289
89R:R:I323 R:R:V267 14.82636.14NoNo087
90R:R:L319 R:R:V267 14.37555.96NoNo067
91R:R:L319 R:R:S315 13.92684.5NoNo065
92R:R:N316 R:R:W272 15.295819.21NoYes099
93R:R:A313 R:R:W272 13.04483.89NoYes089
94R:R:A313 R:R:E275 12.59464.53NoNo086
95R:R:D105 R:R:N320 22.932812.12YesYes299
96R:R:L101 R:R:S144 17.96713YesYes299
97R:R:L108 R:R:S144 27.31734.5YesYes079
98R:R:L108 R:R:N140 33.97544.12YesNo078
99R:R:F136 R:R:N140 30.20058.46NoNo2658
100R:R:F132 R:R:F136 28.31313.22NoNo055
101R:R:F132 R:R:M133 26.42572.49NoNo054
102R:R:M133 R:R:Y123 24.53827.18NoYes048
103B:B:K78 B:B:P94 16.72035.02YesNo085
104A:A:R231 A:A:W234 40.75078YesYes199
105A:A:F238 A:A:W234 14.37684.01YesYes199
106A:A:F246 A:A:I276 15.06235.02YesNo198
107A:A:F238 A:A:L44 14.369219.49YesYes199
108B:B:D212 B:B:E215 11.192816.89NoNo093
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8XOI
Class A
SubFamily Steroid
Type Estrogen
SubType GPER1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.2
Date 2024-04-10
D.O.I. To be published
Net Summary
Imin 2.85
Number of Linked Nodes 852
Number of Links 1126
Number of Hubs 211
Number of Links mediated by Hubs 745
Number of Communities 30
Number of Nodes involved in Communities 321
Number of Links involved in Communities 487
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 19989149
Length Of Smallest Path 3
Average Path Length 59.9298
Length of Longest Path 66
Minimum Path Strength 1.35
Average Path Strength 8.00356
Maximum Path Strength 22.23
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.04082
Average % Of Corr. Nodes 32.6268
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.5713
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8XOI_Chain_A
EDKAAVERS KMIEKQLQK DKQVYRRTL RLLLLGADN SGKSTIVKQ 
MRITSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ CFNDVTAII 
FVVDSSDNR LQEALNDFD SIWNNRWLR TISVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRKEFV 
DISTASGDG RHICYPHFT CAVDTENAR RIFNDCKDI ILQMNLREY 
NLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8XOI_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8XOI_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99527
Sequence
>8XOI_Chain_R
HQQYVIGLF LSCLYTIFL FPIGFVGNI LILVVNISF REKMTIPDL 
YFINLAVAD LILVADSLI EVFNLHERY YDIAVLCTF MSLFLQVNM 
YSSVFFLTW MSFDRYIAL ARAMRCSLF RTKHHARLS CGLIWMASV 
SATLVPFTA VHLQHDVRE VQWLEVTLG FIVPFAIIG LCYSLIVRV 
LVRAHRHRR RQKALRMIL AVVLVFFVC WLPENVFIS VHLLQHAHP 
LTGHIVNLA AFSNSCLNP LIYSFLGET FRDKLRLYI EQK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XOGASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.92024-04-10To be published
8XOHASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22024-04-10To be published
8XOIASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22024-04-10To be published
8XOJASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.12024-04-10To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XOI.zip



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