Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 8.545483
2A:A:N50 6.864149
3A:A:F219 7.16608
4A:A:H220 9.5125417
5A:A:F222 7.626517
6A:A:Q227 5.402519
7A:A:R228 5.83409
8A:A:R231 8.545419
9A:A:R232 9.3425418
10A:A:K233 6.2025819
11A:A:W234 6.48333619
12A:A:F238 8.17167619
13A:A:F246 4.61333619
14A:A:D249 8.654148
15A:A:D252 7.08254148
16A:A:L270 5.885406
17A:A:D272 6.555418
18A:A:F273 5.75333619
19A:A:I276 4.985418
20A:A:W277 7.80429716
21A:A:W281 9.81833615
22A:A:L282 5.97419
23A:A:I288 5.29409
24A:A:F290 9.31754119
25A:A:L291 4.0775418
26A:A:N292 6.4525409
27A:A:K293 7.4409
28A:A:F312 4.024508
29A:A:F315 11.614506
30A:A:P321 3.912505
31A:A:E330 6.1503
32A:A:D331 8.2275404
33A:A:K338 8.9325415
34A:A:Y339 6.515413
35A:A:F340 10.2725407
36A:A:F345 5.976518
37A:A:S349 4.35407
38A:A:Y360 9.5085198
39A:A:F363 9.868515
40A:A:T364 9.694119
41A:A:N371 5.1565119
42A:A:R373 6.795495
43A:A:R374 7.6145114
44A:A:F376 4.88875898
45A:A:L388 4.55508
46A:A:Y391 12.7625424
47A:A:N392 2.8475407
48B:B:L7 5.325408
49B:B:L14 3.862508
50B:B:L51 7.4825459
51B:B:H54 11.9125409
52B:B:M61 4.535456
53B:B:W63 6.85667657
54B:B:D76 7.456589
55B:B:I80 8.92458
56B:B:I81 5.724237
57B:B:W82 9.69333659
58B:B:N88 5.5475407
59B:B:K89 6.998559
60B:B:I93 5.405407
61B:B:L95 5.6625158
62B:B:W99 10.2317619
63B:B:M101 7.9125409
64B:B:N110 7.23754104
65B:B:Y111 7.2945104
66B:B:V112 5.0425408
67B:B:L117 4.0025419
68B:B:I123 4.645106
69B:B:Y124 5.666506
70B:B:H142 7.174519
71B:B:Y145 6.06444918
72B:B:C149 3.84418
73B:B:F151 5.98333609
74B:B:L152 4.51754243
75B:B:I157 5.6275407
76B:B:T159 5.03519
77B:B:D163 9.295419
78B:B:C166 4.016548
79B:B:W169 8.935618
80B:B:F180 7.095647
81B:B:H183 8.888549
82B:B:D186 7.7025419
83B:B:V187 4.6625449
84B:B:L190 5.3325445
85B:B:F199 6.93167649
86B:B:S201 4.6075449
87B:B:C204 6.165417
88B:B:D205 7.015449
89B:B:K209 10.016546
90B:B:W211 8.946548
91B:B:Q220 7.3475437
92B:B:F222 9.1075438
93B:B:H225 10.345639
94B:B:D228 8.205419
95B:B:I229 5.61437
96B:B:F235 5.9965126
97B:B:P236 6.7254127
98B:B:F241 9.11536
99B:B:D247 6.98167639
100B:B:T249 6.555436
101B:B:R251 10.78638
102B:B:F253 8.17333636
103B:B:D254 5.25409
104B:B:R256 8.7675409
105B:B:D258 9.146537
106B:B:Q259 4.066506
107B:B:M262 6.52404
108B:B:Y264 7.892505
109B:B:F278 5.9185127
110B:B:R283 7.1125219
111B:B:L284 5.1405
112B:B:Y289 7.62567
113B:B:D290 6.7425416
114B:B:N295 9.4325466
115B:B:W297 8.268568
116B:B:L300 6.24216
117B:B:K301 6.595405
118B:B:R304 9.6225465
119B:B:V307 3.99463
120B:B:H311 7.256579
121B:B:R314 12.156518
122B:B:M325 4.8505
123B:B:W332 8.98333619
124B:B:D333 8.4675479
125B:B:L336 4.465457
126B:B:K337 7.255476
127B:B:W339 7.85667679
128G:G:Y40 9.994126
129G:G:D48 5.905409
130G:G:L51 4.0075406
131G:G:F61 6.071676228
132R:R:Y65 4.877135
133R:R:F70 6.44407
134R:R:F74 4.42754266
135R:R:I80 5.87529
136R:R:V83 5.125407
137R:R:N84 5.8675427
138R:R:I93 5.746506
139R:R:P94 8.794527
140R:R:D95 7.255428
141R:R:Y97 8.655407
142R:R:D105 6.63509
143R:R:H120 9.6775404
144R:R:Y142 5.836676177
145R:R:S143 5.195407
146R:R:F147 10.124168
147R:R:W150 7.965407
148R:R:R155 10.4025429
149R:R:I157 4.865405
150R:R:R169 7.972527
151R:R:T189 5.3854177
152R:R:W216 7.594295
153R:R:V219 3.45406
154R:R:P226 4.0925409
155R:R:F227 7.085406
156R:R:Y234 6.61529
157R:R:R254 6.886506
158R:R:I261 4.6875408
159R:R:F268 6.764529
160R:R:W272 7.505429
161R:R:L273 4.9825405
162R:R:F278 5.155405
163R:R:H307 6.1025403
164R:R:N316 8.6675429
165R:R:C318 5.134138
166R:R:N320 7.91429
167R:R:Y324 5.90714729
168R:R:F326 4.84527
169R:R:F331 6.222528
170R:R:K334 6.0175425
171R:R:Y338 5.325405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:S74 19.67947.36YesNo099
2B:B:H54 B:B:S74 19.618316.74YesNo099
3A:A:R42 A:A:Y37 20.93318.52NoYes093
4A:A:Y37 B:B:D76 20.05093.45YesYes839
5A:A:F222 A:A:R42 21.00323.21YesNo079
6A:A:K293 A:A:N292 98.60158.39YesYes099
7A:A:D249 A:A:K293 98.974813.83YesYes089
8A:A:D249 A:A:D252 99.27753.99YesYes1488
9A:A:D252 A:A:N264 99.65410.77YesNo089
10A:A:L266 A:A:N264 99.86178.24NoNo089
11A:A:F312 A:A:L266 1004.87YesNo088
12A:A:F312 A:A:Q267 99.77214.68YesNo084
13A:A:L270 A:A:Q267 99.90866.65YesNo064
14A:A:F345 A:A:L270 75.62597.31YesYes086
15A:A:F345 A:A:V248 25.04766.55YesNo087
16A:A:F246 A:A:V248 25.05753.93YesNo097
17A:A:F246 A:A:L46 45.72033.65YesNo198
18A:A:L44 A:A:L46 45.67598.3NoNo098
19A:A:F238 A:A:L44 25.936619.49YesNo099
20A:A:F222 A:A:F238 20.83763.22YesYes179
21A:A:F273 A:A:F345 25.26497.5YesYes198
22A:A:F246 A:A:F273 50.3844.29YesYes199
23A:A:I348 A:A:L270 25.27114.28NoYes046
24A:A:F273 A:A:I348 25.28246.28YesNo094
25A:A:F345 A:A:L289 25.03134.87YesNo189
26A:A:F246 A:A:L289 25.61664.87YesNo199
27A:A:I244 A:A:L44 19.74534.28NoNo089
28A:A:I276 A:A:R231 27.56776.26YesYes189
29A:A:R231 A:A:W234 15.722211YesYes199
30A:A:N292 A:A:T364 95.79245.85YesYes099
31A:A:R374 A:A:T364 31.96439.06YesYes1149
32A:A:W234 B:B:Y145 15.08194.82YesYes198
33A:A:D272 A:A:R231 27.577211.91YesYes189
34A:A:I235 A:A:L282 39.22984.28NoYes199
35A:A:I244 A:A:L282 19.6155.71NoYes189
36A:A:F290 A:A:I288 31.6533.77YesYes099
37A:A:F290 A:A:T364 63.077719.46YesYes1199
38A:A:L282 A:A:N279 58.65419.61YesNo098
39A:A:W281 B:B:D290 57.0833.35YesYes156
40A:A:D381 R:R:R254 87.899510.72NoYes086
41A:A:D381 A:A:Y360 92.73276.9NoYes088
42A:A:D378 A:A:Y360 93.73613.79NoYes078
43A:A:D378 A:A:I288 31.330711.2NoYes079
44A:A:D378 A:A:H362 62.656112.61NoNo079
45A:A:F290 A:A:H362 31.39686.79YesNo099
46A:A:H362 A:A:R374 31.425412.41NoYes094
47A:A:Y391 R:R:R155 21.532917.49YesYes249
48A:A:L393 R:R:R155 81.3239.72NoYes089
49A:A:L388 A:A:L393 84.12955.54YesNo088
50A:A:L384 A:A:L388 85.13475.54NoYes068
51A:A:L384 R:R:R254 85.38614.86NoYes066
52A:A:Y391 R:R:P94 15.887918.08YesYes247
53A:A:N392 R:R:F98 15.97522.42YesNo078
54R:R:M151 R:R:Y324 11.16714.79NoYes089
55R:R:R155 R:R:Y324 58.60626.17YesYes299
56B:B:M262 B:B:Y264 10.73699.58YesYes045
57B:B:L252 B:B:Y264 33.67997.03NoYes075
58B:B:L252 B:B:L261 33.29364.15NoNo075
59B:B:D254 B:B:L261 32.90765.43YesNo095
60B:B:A257 B:B:D254 29.8314.63NoYes079
61B:B:A257 B:B:Q259 29.44463.03NoYes076
62B:B:Q259 B:B:R22 27.89857.01YesNo066
63B:B:I18 B:B:R22 12.41557.52NoNo076
64B:B:I18 G:G:A23 12.02793.25NoNo078
65B:B:L14 G:G:A23 11.64031.58YesNo088
66B:B:D258 B:B:R22 15.12813.1YesNo076
67B:B:G162 B:B:Y145 13.30197.24NoYes198
68B:B:G162 B:B:S161 13.16773.71NoNo199
69B:B:H142 B:B:S161 12.5915.34YesNo199
70B:B:D258 B:B:F222 10.47463.58YesYes378
71B:B:W297 B:B:Y264 54.359810.61YesYes085
72B:B:R304 B:B:W297 27.354311YesYes658
73B:B:N295 B:B:W297 27.35434.52YesYes668
74B:B:N295 B:B:V307 28.88985.91YesYes663
75B:B:N293 B:B:V307 57.18874.43NoYes053
76B:B:D291 B:B:N293 57.37469.42NoNo085
77B:B:R304 B:B:V307 27.92793.92YesYes653
78R:R:N320 R:R:Y324 38.80185.81YesYes299
79R:R:D105 R:R:N320 21.12579.42YesYes099
80A:A:N392 R:R:F331 12.37332.42YesYes078
81R:R:D105 R:R:S144 12.11934.42YesNo099
82R:R:N316 R:R:N320 17.559.54YesYes299
83R:R:F268 R:R:N316 12.9144.83YesYes299
84R:R:F227 R:R:F268 10.35727.5YesYes069
85B:B:C271 B:B:D291 57.56093.11NoNo058
86B:B:L70 B:B:W82 10.45765.69NoYes559
87B:B:C271 B:B:D290 57.74793.11NoYes056
88A:A:F246 A:A:I276 27.61683.77YesYes198
89A:A:D272 A:A:F246 27.67877.17YesYes189
90A:A:I235 A:A:R231 39.31115.01NoYes199
91A:A:N279 A:A:W281 58.46823.39NoYes085
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8XOG
Class A
SubFamily Steroid
Type Estrogen
SubType GPER1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.9
Date 2024-04-10 
D.O.I. To be published
Net Summary
Imin 3.21
Number of Linked Nodes 861
Number of Links 1032
Number of Hubs 171
Number of Links mediated by Hubs 630
Number of Communities 29
Number of Nodes involved in Communities 229
Number of Links involved in Communities 325
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 8624873
Length Of Smallest Path 3
Average Path Length 45.3984
Length of Longest Path 71
Minimum Path Strength 1.31
Average Path Strength 7.58743
Maximum Path Strength 20.005
Minimum Path Correlation 0.71
Average Path Correlation 0.995802
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.78571
Average % Of Corr. Nodes 28.8043
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.0331
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8XOG_Chain_A
EDKAAVERS KMIEKQLQK DKQVYRRTL RLLLLGADN SGKSTIVKQ 
MRITSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ CFNDVTAII 
FVVDSSDNR LQEALNDFD SIWNNRWLR TISVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRKEFV 
DISTASGDG RHICYPHFT CAVDTENAR RIFNDCKDI ILQMNLREY 
NLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8XOG_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8XOG_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99527
Sequence
>8XOG_Chain_R
HQQYVIGLF LSCLYTIFL FPIGFVGNI LILVVNISF REKMTIPDL 
YFINLAVAD LILVADSLI EVFNLHERY YDIAVLCTF MSLFLQVNM 
YSSVFFLTW MSFDRYIAL ARAMRCSLF RTKHHARLS CGLIWMASV 
SATLVPFTA VHLQHDVRE VQWLEVTLG FIVPFAIIG LCYSLIVRV 
LVRAHRHRR RQKALRMIL AVVLVFFVC WLPENVFIS VHLLQHAHP 
LTGHIVNLA AFSNSCLNP LIYSFLGET FRDKLRLYI EQK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XOGASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.92024-04-10To be published
8XOHASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22024-04-10To be published
8XOIASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22024-04-10To be published
8XOJASteroidEstrogenGPER1Homo sapiens--chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.12024-04-10To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XOG.zip



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